Health care outcome, Cardiovascular diseases, Pharmaceuetical Care, Clinical Pharmacology
27
Scopus Publications
420
Scholar Citations
10
Scholar h-index
10
Scholar i10-index
Scopus Publications
Oral Anticoagulant Use in Patients with Atrial Fibrillation at Low Risk of Stroke and Associated Bleeding Complications Adane Teshome Kefale, Woldesellassie M. Bezabhe, Gregory M. Peterson Journal of Clinical Medicine, 2023 Background: The use of oral anticoagulants (OACs) in patients with atrial fibrillation (AF) and low stroke risk might cause more harm than benefit. Little attention has been given to address its prevalence and associated consequences. This study aimed to investigate the prescription rate of OACs, identify associated factors, and describe incident bleeding events in low-risk patients. Methods: We included patients with a new diagnosis of AF between 1 January 2011 and 31 December 2018 having a low risk of stroke (CHA2DS2-VASc score of 0 for males and 1 for females) from Australian general practice data (MedicineInsight). Patients were classified as OAC users if there was a recorded prescription of an OAC within 60 days of AF diagnosis, and factors associated with the prescription of an OAC were assessed using logistic regression. Recorded incident bleeding events were identified within 6 months after AF diagnosis or after OAC initiation for OAC non-users and users, respectively. The risk of bleeding was compared between the two groups by adjusting their baseline differences using propensity score matching. Results: The study included 2810 low-risk patients (62.3% male) with a mean age of 49.3 ± 10.8 years. Of the total, 705 (25.1%) patients had a record of OAC prescription within 60 days of diagnosis of AF. Older age (odds ratio [OR] 1.03; 95% confidence interval [CI] 1.03–1.04) and diagnosis periods (2015–2016 [OR 1.46; 95% CI 1.10–1.94] and 2017–2018 [OR 1.65; 95% CI 1.17–2.23] vs. 2011–2012) were associated with higher odds of OAC initiation. Female sex (OR 0.71; 95% CI 0.59–0.85), higher bleeding risk (ORBIT score; OR 0.80; 95% CI 0.68–0.94), and higher socioeconomic index for areas (SEIFA) quintiles (SEIFA quintiles; 2 [OR 0.65; 95% CI 0.48–0.88], 3 [OR 0.74; 95% CI 0.56–0.98], 4 [OR 0.70; 95% CI 0.52–0.94], 5 [OR 0.69; 95% CI 0.52–0.91] compared with quintile 1) were associated with lower odds of OAC prescription. A total of 52 (in 1.8% of patients) incident bleeds were identified, with 18 (2.6%) among OAC users. The rate of bleeding was not significantly different between users and non-users after matching. However, within OAC users, commencement of OAC was associated with an increased risk of bleeding compared to the period before OAC initiation (p = 0.006). Conclusions: One in four patients at low risk of stroke received an OAC within 60 days of AF diagnosis. Older age and the period following the widespread availability of direct-acting OACs were associated with an increased likelihood of OAC prescription. Positively, using OACs was not associated with an increased rate of bleeding compared to non-users.
Clinical outcomes of oral anticoagulant discontinuation in atrial fibrillation: a systematic review and meta-analysis Adane Teshome Kefale, Woldesellassie M. Bezabhe, Gregory M. Peterson Expert Review of Clinical Pharmacology, 2023 INTRODUCTION Oral anticoagulants (OACs) should generally be continued lifelong in patients with atrial fibrillation (AF) to ensure optimal benefits, unless contraindications arise. However, discontinuation of OACs might occur for various reasons, potentially affecting clinical outcomes. In this review, we synthesized evidence on the clinical outcomes following OAC discontinuation in patients with AF. METHODS We conducted a systematic review and meta-analysis using PubMed, Embase and Scopus. Cohort or case-control studies were included if data were available on clinical outcomes of OAC discontinuation, compared with continuation, in patients with AF. A random-effect meta-analyses were conducted for key outcomes of stroke, mortality, and major bleeding. RESULTS Eighteen observational studies having a total of 283,418 patients were included. Discontinuation significantly increased the risk of stroke (hazard ratio [HR] 1.88; 95% confidence interval [CI] 1.58-2.23), all-cause (HR 1.90; 95% CI 1.40-2.59) and cardiovascular (HR 1.83; 95% CI 1.06-3.18) mortality. The risk of major bleeding was not significantly different between the discontinued and continued groups (HR 1.04; 95% CI 0.72-1.52). CONCLUSIONS Discontinuation of OAC therapy was associated with an increased risk of stroke and mortality, with no difference in the risk of major bleeding. Acknowledging heterogeneity among the studies, the findings underline the need to ensure continuity of OAC therapy in patients with AF to prevent thrombotic complications and associated mortality. PROSPERO REGISTRATION NUMBER CRD42020186116.
Oral Anticoagulant Discontinuation and Its Predictors in Patients with Atrial Fibrillation Adane Teshome Kefale, Woldesellassie M. Bezabhe, Gregory M. Peterson Journal of Clinical Medicine, 2022 Background: Oral anticoagulants (OACs) are important in reducing the risk of ischaemic stroke in people with atrial fibrillation (AF). Although patients need to take their OAC continuously, it has been suggested that discontinuation is common in clinical practice, and this could predispose patients to thrombotic complications. Aims: To investigate the rate of OAC discontinuation and its predictors in patients with AF, using national data from Australian general practices. Methods: We analysed data obtained from NPS MedicineWise’s MedicineInsight dataset. We included patients with a recorded diagnosis of AF who newly started an OAC between 1 January 2013 and 31 December 2017. Patients were considered persistent if an OAC was prescribed continuously without discontinuing more than 60 days gap in therapy. The follow-up period was 12 months post-initiation. Multivariable models were used for the analysis of predictors. Results: Of 16,075 patients included in the cohort, 47.3% were females, and the mean age was 74.6 (SD 10.2) years. The overall OAC discontinuation rate was 13.2% (confidence interval (CI) 12.6–13.7%) by 12 months post-initiation. The discontinuation rates for warfarin, apixaban, dabigatran and rivaroxaban were 18.3% (95% CI 17.2–19.5%), 10.1% (95% CI 9.2–11.0%), 10.9% (95% CI 9.4–12.5%) and 12.2% (95% CI 11.4–13.2%), respectively. Warfarin had a significantly higher risk of discontinuation compared to direct-acting OACs. Factors that are known to increase the risk of stroke (older age, diabetes, and hypertension) were associated with better persistence. Conclusions: A relatively high proportion of patients with AF continued OAC therapy by 12 months post-initiation. Positively, patients with the highest risk of stroke and lowest risk of bleeds seemed to have better persistence.
Switching of oral anticoagulants in patients with nonvalvular atrial fibrillation: A narrative review Adane Teshome Kefale, Gregory M. Peterson, Woldesellassie M. Bezabhe, Luke R. Bereznicki British Journal of Clinical Pharmacology, 2022 Approval of direct-acting oral anticoagulants (DOACs) for stroke prevention in atrial fibrillation (AF) was an important milestone, providing a wider range of treatment options and creating the possibility for drug switching after initiation. In addition to improved utilisation of oral anticoagulants (OACs) for stroke prevention, reports of switching among OACs are growing in the literature; switching may influence clinical outcomes, healthcare costs and patient satisfaction. This review aimed to summarise the current literature on the pattern of OAC switching in patients with AF, including reasons for switching and clinical consequences following switching. A literature search was conducted in PubMed, Scopus, and Embase on Jun 27, 2020. We included 39 articles published after 2013, following the introduction of apixaban. The review found that switching among OACs was common in clinical practice, significantly varying with the type of OAC. Studies reporting the reason for switching and clinical outcomes were comparatively limited. The decision to switch was often related to safety issues (usually bleeding), poor anticoagulation control and ease-of-use. Patient characteristics, clinical conditions and drug interactions were found to be associated with switching from OACs. Findings regarding bleeding outcomes following switching were inconsistent, possibly confounded by the rationale for switching and the switching protocol. Noting the limited number of studies included and their relatively short follow-up periods, switching did not have a significant impact on the risk of stroke and other thrombotic outcomes. Further prospective studies are needed to understand better potential rationales for switching and the clinical outcomes.
Switching of oral anticoagulants in atrial fibrillation: a cohort study using Australian general practice data Adane Teshome Kefale, Gregory M. Peterson, Woldesellassie M. Bezabhe, Luke R. Bereznicki Expert Review of Clinical Pharmacology, 2022 BACKGROUND : We assessed switching patterns of anticoagulants in patients with atrial fibrillation (AF) in the period following widespread availability of the direct-acting oral anticoagulants (DOACs). RESEARCH DESIGN AND METHODS : A retrospective cohort study was conducted using NPS MedicineWise's MedicineInsight dataset, collected from Australian general practices. Patients with AF who newly commenced an OAC between 1 January 2013 and 30 September 2017 were included. The switching rate was calculated within 12 months post-initiation. Switching rates between OACs were compared, and predictors of switching were identified. RESULTS : We included 15,020 patients who were recorded as having been commenced on warfarin or a DOAC. Overall, 5.7% of patients switched their OAC within 12 months. The switching rates from warfarin, apixaban, dabigatran and rivaroxaban were 9.4%, 2.6%, 8.9% and 4.0%, respectively. Compared to apixaban, commencement on warfarin, dabigatran or rivaroxaban was associated with a higher risk of switching to another OAC. Patients with an estimated GFR <30 mL/min were more likely to switch from DOACs to warfarin and less likely to switch from warfarin, compared to those with an estimated GFR >60mL/min. CONCLUSION : There was a low switching rate between OACs in Australian general practice patients with AF. A key determinant of switching appeared to be kidney disease.
Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia Addisu Desta, Tessema Tsehay Biru, Adane Teshome Kefale Plos One, 2020 Background Highly Active Antiretroviral Therapy (HAART) is a standard of HIV management to suppress viral load and delay progression to AIDS. However, questions have been raised about the use of antiretroviral therapy and how it affects quality of life (QoL) of people living with HIV/AIDS (PLWHA). The study hence aimed to assess the QoL of PLWHA who were taking HAART at Mizan–Tepi University Teaching Hospital (MTUTH) and identify factors associated with QoL. Methods A cross sectional study was conducted among PLWHA receiving HAART at MTUTH from March 04-April 1, 2018. Patients were recruited consecutively and interviewed with structured questionnaire. A data abstraction tool was used to extract data from patient medical records. Quality of life was assessed using the World Health Organization Quality of Life HIV- BREF (WHOQOL-HIV-BREF) standard tool. Data was entered to Epi-Info version 3.5.3 and analyzed using SPSS version 22 for windows. A multivariable logistic regression analysis was fitted to identify factors associated with QoL. A statistical significance was established at a p value <0.05. Results A total of 240 participants with the mean age of 35.11 (SD = 9.08) years were included in the study. This study found that 57.1% of the patients had high global score of QoL. Patients with normal current health (AOR = 3.38, 95% CI = 1.56–7.31)) and having family support (AOR = 3.12, 95% CI = 1.51–6.46) were positively associated with high global score of QoL, while patients with low HAART adherence (AOR = 0.40, 95%, CI = 0.19–0.86) were negatively associated with high global score of QoL. Conclusion The study revealed that more than half of the participants had high global score of QoL. Normal current health and family support were associated with better global score of QoL, while low HAART adherence was found to be associated with the lower global score of QoL.
Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Joan B Soriano, Parkes J Kendrick, Katherine R Paulson, Vinay Gupta, Elissa M Abrams, Rufus Adesoji Adedoyin, Tara Ballav Adhikari, Shailesh M Advani, Anurag Agrawal, Elham Ahmadian, Fares Alahdab, Syed Mohamed Aljunid, Khalid A Altirkawi, Nelson Alvis-Guzman, Nahla Hamed Anber, Catalina Liliana Andrei, Mina Anjomshoa, Fereshteh Ansari, Josep M Antó, Jalal Arabloo, Seyyede Masoume Athari, Seyyed Shamsadin Athari, Nefsu Awoke, Alaa Badawi, Joseph Adel Mattar Banoub, Derrick A Bennett, Isabela M Bensenor, Kathleen S Sachiko Berfield, Robert S Bernstein, Krittika Bhattacharyya, Ali Bijani, Michael Brauer, Gene Bukhman, Zahid A Butt, Luis Alberto Cámera, Josip Car, Juan J Carrero, Felix Carvalho, Carlos A Castañeda-Orjuela, Jee-Young Jasmine Choi, Devasahayam J Christopher, Aaron J Cohen, Lalit Dandona, Rakhi Dandona, Anh Kim Dang, Ahmad Daryani, Barbora de Courten, Feleke Mekonnen Demeke, Gebre Teklemariam Demoz, Jan-Walter De Neve, Rupak Desai, Samath Dhamminda Dharmaratne, Daniel Diaz, Abdel Douiri, Tim Robert Driscoll, Eyasu Ejeta Duken, Aziz Eftekhari, Hajer Elkout, Aman Yesuf Endries, Ibtihal Fadhil, Andre Faro, Farshad Farzadfar, Eduarda Fernandes, Irina Filip, Florian Fischer, Masoud Foroutan, M.A. Garcia-Gordillo, Abadi Kahsu Gebre, Ketema Bizuwork Gebremedhin, Gebreamlak Gebremedhn Gebremeskel, Kebede Embaye Gezae, Aloke Gopal Ghoshal, Paramjit Singh Gill, Richard F Gillum, Houman Goudarzi, Yuming Guo, Rajeev Gupta, Gessessew Bugssa Hailu, Amir Hasanzadeh, Hamid Yimam Hassen, Simon I Hay, Chi Linh Hoang, Michael K Hole, Nobuyuki Horita, H Dean Hosgood, Mihaela Hostiuc, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D Ilic, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Mihajlo Jakovljevic, Amr A Jamal, Ravi Prakash Jha, Jost B Jonas, Zubair Kabir, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Getachew Mullu Kassa, Adane Teshome Kefale, Andre Pascal Kengne, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Ejaz Ahmad Khan, Junaid Khan, Jagdish Khubchandani, Young-Eun Kim, Yun Jin Kim, Sezer Kisa, Adnan Kisa, Luke D Knibbs, Hamidreza Komaki, Parvaiz A Koul, Ai Koyanagi, G Anil Kumar, Qing Lan, Savita Lasrado, Paolo Lauriola, Carlo La Vecchia, Tham Thi Le, James Leigh, Miriam Levi, Shanshan Li, Alan D Lopez, Paulo A Lotufo, Fabiana Madotto, Narayan B Mahotra, Marek Majdan, Azeem Majeed, Reza Malekzadeh, Abdullah A Mamun, Navid Manafi, Farzad Manafi, Lorenzo Giovanni Mantovani, Birhanu Geta Meharie, Hagazi Gebre Meles, Gebrekiros Gebremichael Meles, Ritesh G Menezes, Tomislav Mestrovic, Ted R Miller, GK Mini, Erkin M Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Farnam Mohebi, Ali H Mokdad, Mariam Molokhia, Lorenzo Monasta, Masoud Moradi, Ghobad Moradi, Lidia Morawska, Seyyed Meysam Mousavi, Kamarul Imran Musa, Ghulam Mustafa, Mehdi Naderi, Mohsen Naghavi, Gurudatta Naik, Sanjeev Nair, Vinay Nangia, Jobert Richie Nansseu, Javad Nazari, Duduzile Edith Ndwandwe, Ruxandra Irina Negoi, Trang Huyen Nguyen, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Molly R Nixon, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T Olagunju, Tinuke O Olagunju, Eyal Oren, Justin R Ortiz, Mayowa O Owolabi, Mahesh P A, Smita Pakhale, Adrian Pana, Songhomitra Panda-Jonas, Eun-Kee Park, Hai Quang Pham, Maarten J Postma, Hadi Pourjafar, Hossein Poustchi, Amir Radfar, Alireza Rafiei, Fakher Rahim, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Salman Rawaf, David Laith Rawaf, Lal Rawal, Robert C Reiner Jr., Marissa Bettay Reitsma, Leonardo Roever, Luca Ronfani, Elias Merdassa Roro, Gholamreza Roshandel, Kristina E Rudd, Yogesh Damodar Sabde, Siamak Sabour, Basema Saddik, Saeed Safari, Komal Saleem, Abdallah M Samy, Milena M Santric-Milicevic, Bruno Piassi Sao Jose, Benn Sartorius, Maheswar Satpathy, Miloje Savic, Monika Sawhney, Sadaf G Sepanlou, Masood Ali Shaikh, Aziz Sheikh, Mika Shigematsu, Reza Shirkoohi, Si Si, Soraya Siabani, Virendra Singh, Jasvinder A Singh, Michael Soljak, Ranjani Somayaji, Moslem Soofi, Ireneous N Soyiri, Yonatal Mesfin Tefera, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Jarnail Singh Thakur, Alemayehu Toma Toma, Miguel Tortajada-Girbés, Khanh Bao Tran, Bach Xuan Tran, Lorainne Tudor Car, Irfan Ullah, Marco Vacante, Pascual R Valdez, Job F M van Boven, Tommi Juhani Vasankari, Yousef Veisani, Francesco S Violante, Gregory R Wagner, Ronny Westerman, Charles D A Wolfe, Dawit Zewdu Wondafrash, Adam Belay Wondmieneh, Naohiro Yonemoto, Seok-Jun Yoon, Zoubida Zaidi, Mohammad Zamani, Heather J Zar, Yunquan Zhang, Theo Vos Lancet Respiratory Medicine, 2020 Summary Background Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma. In this study, we aimed to characterise the burden of chronic respiratory diseases globally, providing a comprehensive and up-to-date analysis on geographical and time trends from 1990 to 2017. Methods Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we estimated the prevalence, morbidity, and mortality attributable to chronic respiratory diseases through an analysis of deaths, disability-adjusted life-years (DALYs), and years of life lost (YLL) by GBD super-region, from 1990 to 2017, stratified by age and sex. Specific diseases analysed included asthma, COPD, interstitial lung disease and pulmonary sarcoidosis, pneumoconiosis, and other chronic respiratory diseases. We also assessed the contribution of risk factors (smoking, second-hand smoke, ambient particulate matter and ozone pollution, household air pollution from solid fuels, and occupational risks) to chronic respiratory disease-attributable DALYs. Findings In 2017, 544·9 million people (95% uncertainty interval [UI] 506·9–584·8) worldwide had a chronic respiratory disease, representing an increase of 39·8% compared with 1990. Chronic respiratory disease prevalence showed wide variability across GBD super-regions, with the highest prevalence among both males and females in high-income regions, and the lowest prevalence in sub-Saharan Africa and south Asia. The age-sex-specific prevalence of each chronic respiratory disease in 2017 was also highly variable geographically. Chronic respiratory diseases were the third leading cause of death in 2017 (7·0% [95% UI 6·8–7·2] of all deaths), behind cardiovascular diseases and neoplasms. Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578–4 044 819) in 2017, an increase of 18·0% since 1990, while total DALYs increased by 13·3%. However, when accounting for ageing and population growth, declines were observed in age-standardised prevalence (14·3% decrease), age-standardised death rates (42·6%), and age-standardised DALY rates (38·2%). In males and females, most chronic respiratory disease-attributable deaths and DALYs were due to COPD. In regional analyses, mortality rates from chronic respiratory diseases were greatest in south Asia and lowest in sub-Saharan Africa, also across both sexes. Notably, although absolute prevalence was lower in south Asia than in most other super-regions, YLLs due to chronic respiratory diseases across the subcontinent were the highest in the world. Death rates due to interstitial lung disease and pulmonary sarcoidosis were greater than those due to pneumoconiosis in all super-regions. Smoking was the leading risk factor for chronic respiratory disease-related disability across all regions for men. Among women, household air pollution from solid fuels was the predominant risk factor for chronic respiratory diseases in south Asia and sub-Saharan Africa, while ambient particulate matter represented the leading risk factor in southeast Asia, east Asia, and Oceania, and in the Middle East and north Africa super-region. Interpretation Our study shows that chronic respiratory diseases remain a leading cause of death and disability worldwide, with growth in absolute numbers but sharp declines in several age-standardised estimators since 1990. Premature mortality from chronic respiratory diseases seems to be highest in regions with less-resourced health systems on a per-capita basis. Funding Bill & Melinda Gates Foundation.
The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Sadaf G Sepanlou, Saeid Safiri, Catherine Bisignano, Kevin S Ikuta, Shahin Merat, Mehdi Saberifiroozi, Hossein Poustchi, Derrick Tsoi, Danny V Colombara, Amir Abdoli, Rufus Adesoji Adedoyin, Mohsen Afarideh, Sutapa Agrawal, Sohail Ahmad, Elham Ahmadian, Ehsan Ahmadpour, Tomi Akinyemiju, Chisom Joyqueenet Akunna, Vahid Alipour, Amir Almasi-Hashiani, Abdulaziz M Almulhim, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Nahla Hamed Anber, Colin Angus, Amir Anoushiravani, Jalal Arabloo, Ephrem Mebrahtu Araya, Daniel Asmelash, Bahar Ataeinia, Zerihun Ataro, Maha Moh'd Wahbi Atout, Floriane Ausloos, Ashish Awasthi, Alaa Badawi, Maciej Banach, Diana Fernanda Bejarano Ramirez, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Krittika Bhattacharyya, Antonio Biondi, Srinivasa Rao Bolla, Archith Boloor, Antonio M Borzì, Zahid A Butt, Luis LA Alberto Cámera, Ismael R Campos-Nonato, Félix Carvalho, Dinh-Toi Chu, Sheng-Chia Chung, Paolo Angelo Cortesi, Vera M Costa, Benjamin C Cowie, Ahmad Daryani, Barbora de Courten, Gebre Teklemariam Demoz, Rupak Desai, Samath Dhamminda Dharmaratne, Shirin Djalalinia, Hoa Thi Do, Fariba Dorostkar, Thomas M Drake, Manisha Dubey, Bruce B Duncan, Andem Effiong, Aziz Eftekhari, Aisha Elsharkawy, Arash Etemadi, Mohammad Farahmand, Farshad Farzadfar, Eduarda Fernandes, Irina Filip, Florian Fischer, Ketema Bizuwork Bizuwork Gebremedhin, Birhanu Geta, Syed Amir Gilani, Paramjit Singh Gill, Reyna Alma Gutirrez, Michael Tamene Haile, Arvin Haj-Mirzaian, Saeed S Hamid, Milad Hasankhani, Amir Hasanzadeh, Maryam Hashemian, Hamid Yimam Hassen, Simon I Hay, Khezar Hayat, Behnam Heidari, Andualem Henok, Chi Linh Hoang, Mihaela Hostiuc, Sorin Hostiuc, Vivian Chia-rong Hsieh, Ehimario U Igumbor, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Nader Jafari Balalami, Spencer L James, Panniyammakal Jeemon, Ravi Prakash Jha, Jost B Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Amir Kasaeian, Hagazi Gebremedhin Kassaye, Adane Teshome Kefale, Rovshan Khalilov, Muhammad Ali Khan, Ejaz Ahmad Khan, Amir Khater, Yun Jin Kim, Ai Koyanagi, Carlo La Vecchia, Lee-Ling Lim, Alan D Lopez, Stefan Lorkowski, Paulo A. Lotufo, Rafael Lozano, Muhammed Magdy Abd El Razek, Hue Thi Mai, Navid Manafi, Amir Manafi, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Giampiero Mazzaglia, Dhruv Mehta, Walter Mendoza, Ritesh G Menezes, Melkamu Merid Mengesha, Tuomo J Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Ted R Miller, Erkin M Mirrakhimov, Prasanna Mithra, Babak Moazen, Masoud Moghadaszadeh, Abdollah Mohammadian-Hafshejani, Shafiu Mohammed, Ali H Mokdad, Pablo A Montero-Zamora, Ghobad Moradi, Mukhammad David Naimzada, Vinod Nayak, Ionut Negoi, Trang Huyen Nguyen, Richard Ofori-Asenso, In-Hwan Oh, Tinuke O Olagunju, Jagadish Rao Padubidri, Keyvan Pakshir, Adrian Pana, Mona Pathak, Akram Pourshams, Navid Rabiee, Amir Radfar, Alireza Rafiei, Kiana Ramezanzadeh, Saleem Muhammad M Rana, Salman Rawaf, David Laith Rawaf, Robert C Reiner, Leonardo Roever, Robin Room, Gholamreza Roshandel, Saeed Safari, Abdallah M Samy, Juan Sanabria, Benn Sartorius, Maria Inês Schmidt, Subramanian Senthilkumaran, Masood Ali Shaikh, Mehdi Sharif, Amrollah Sharifi, Mika Shigematsu, Jasvinder A. Singh, Amin Soheili, Hafiz Ansar Rasul Suleria, Berhane Fseha Teklehaimanot, Berhe Etsay Tesfay, Marco Vacante, Amir Vahedian-Azimi, Pascual R Valdez, Tommi Juhani Vasankari, Giang Thu Vu, Yasir Waheed, Kidu Gidey Weldegwergs, Andrea Werdecker, Ronny Westerman, Dawit Zewdu Wondafrash, Adam Belay Wondmieneh, Yordanos Gizachew Yeshitila, Naohiro Yonemoto, Chuanhua Yu, Zoubida Zaidi, Afshin Zarghi, Shira Zelber-Sagi, Kaleab Alemayehu Zewdie, Zhi-Jiang Zhang, Xiu-Ju Zhao, Mohsen Naghavi, Reza Malekzadeh Lancet Gastroenterology and Hepatology, 2020 Summary Background Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. Methods We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries. Findings In 2017, cirrhosis caused more than 1·32 million (95% UI 1·27–1·45) deaths (440 000 [416 000–518 000; 33·3%] in females and 883 000 [838 000–967 000; 66·7%] in males) globally, compared with less than 899 000 (829 000–948 000) deaths in 1990. Deaths due to cirrhosis constituted 2·4% (2·3–2·6) of total deaths globally in 2017 compared with 1·9% (1·8–2·0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21·0 (19·2–22·3) per 100 000 population in 1990 to 16·5 (15·8–18·1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions for all years of the study period (32·2 [25·8–38·6] deaths per 100 000 population in 2017), and the high-income super-region had the lowest (10·1 [9·8–10·5] deaths per 100 000 population in 2017). The age-standardised death rate decreased or remained constant from 1990 to 2017 in all GBD regions except eastern Europe and central Asia, where the age-standardised death rate increased, primarily due to increases in alcohol-related liver disease prevalence. At the national level, the age-standardised death rate of cirrhosis was lowest in Singapore in 2017 (3·7 [3·3–4·0] per 100 000 in 2017) and highest in Egypt in all years since 1990 (103·3 [64·4–133·4] per 100 000 in 2017). There were 10·6 million (10·3–10·9) prevalent cases of decompensated cirrhosis and 112 million (107–119) prevalent cases of compensated cirrhosis globally in 2017. There was a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017. Cirrhosis caused by NASH had a steady age-standardised death rate throughout the study period, whereas the other four causes showed declines in age-standardised death rate. The age-standardised prevalence of compensated and decompensated cirrhosis due to NASH increased more than for any other cause of cirrhosis (by 33·2% for compensated cirrhosis and 54·8% for decompensated cirrhosis) over the study period. From 1990 to 2017, the number of prevalent cases more than doubled for compensated cirrhosis due to NASH and more than tripled for decompensated cirrhosis due to NASH. In 2017, age-standardised death and DALY rates were lower among countries and territories with higher SDI. Interpretation Cirrhosis imposes a substantial health burden on many countries and this burden has increased at the global level since 1990, partly due to population growth and ageing. Although the age-standardised death and DALY rates of cirrhosis decreased from 1990 to 2017, numbers of deaths and DALYs and the proportion of all global deaths due to cirrhosis increased. Despite the availability of effective interventions for the prevention and treatment of hepatitis B and C, they were still the main causes of cirrhosis burden worldwide, particularly in low-income countries. The impact of hepatitis B and C is expected to be attenuated and overtaken by that of NASH in the near future. Cost-effective interventions are required to continue the prevention and treatment of viral hepatitis, and to achieve early diagnosis and prevention of cirrhosis due to alcohol-related liver disease and NASH. Funding Bill & Melinda Gates Foundation.
Evaluation of abortifacient effect of rumex nepalensis spreng among pregnant swiss albino rats: Laboratory-based study Nikodimos Eshetu Dabe, Adane Teshome Kefale, Tegene Legese Dadi Journal of Experimental Pharmacology, 2020 Background Rumex nepalensis Spreng (Amharic: Yewsha Tult) belongs to the Polygonaceae (buckwheat) family. In Ethiopia, the plant is traditionally used for the treatment of stomach ache, tonsillitis, ascariasis, uterine bleeding, etc. An ethnobotanical study from Mizan–Tepi University also reported the use of the plant by “Shekicho” people as an abortifacient. As a result, this study aimed at the assessment of the outcome of hydro-ethanolic leaves extract of R. nepalensis on Swiss albino pregnant rats and confirm its abortifacient activity. Methods The hydro-alcoholic leaves extract of Rumex nepalensis Spreng was evaluated for its abortifacient activity in Swiss albino rats. The mature female rats were mated overnight to male rats in mating cages. Two different dosage regimens (300 mg/kg, 600 mg/kg) of the extract were administered. Laparotomy was performed on the rats to assess the uterus and ovary, the viable, non-viable, adsorbing sites, and corpora lutea. Differences between the experimental and control groups were compared using one-way analysis of variance (ANOVA), followed by Dunnett’s T-test to determine their level of significance. Results and Discussion This study revealed that Rumex nepalensis Spreng had anti-implantation and abortifacient activities at both 300 and 600 mg/kg doses, which was statistically significant as compared with the controls. It was relatively safe up to the dose of 5000 mg/kg, where no mortality and organ toxicity were manifested. Phytochemicals identified were alkaloids, flavonoids, saponins, tannins, steroids, and anthraquinones. Conclusion In general, our study showed that R. nepalensis had a significant abortifacient activity that testifies its traditional dibs. Therefore, the use of this plant should be avoided in pregnant women to minimize unintended abortion and further studies are needed to know its mechanism of activity and to identify the phytochemicals corresponding to this activity. Checking its efficacy on other species is also needed.
Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017 Christopher E Troeger, Ibrahim A Khalil, Brigette F Blacker, Molly H Biehl, Samuel B Albertson, Stephanie R M Zimsen, Puja C Rao, Degu Abate, Amha Admasie, Alireza Ahmadi, Mohamed Lemine Cheikh Brahim Ahmed, Chalachew Genet Akal, Fares Alahdab, Noore Alam, Kefyalew Addis Alene, Vahid Alipour, Syed Mohamed Aljunid, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Saeed Amini, Mina Anjomshoa, Carl Abelardo T Antonio, Jalal Arabloo, Olatunde Aremu, Hagos Tasew Atalay, Suleman Atique, Euripide F G A Avokpaho, Samah Awad, Ashish Awasthi, Alaa Badawi, Kalpana Balakrishnan, Joseph Adel Mattar Banoub, Aleksandra Barac, Quique Bassat, Neeraj Bedi, Derrick A Bennett, Krittika Bhattacharyya, Zulfiqar A Bhutta, Ali Bijani, Corey B Bills, Josip Car, Félix Carvalho, Carlos A Castañeda-Orjuela, Kate Causey, Devasahayam J Christopher, Aaron J Cohen, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Feleke Mekonnen Demeke, Shirin Djalalinia, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, Maysaa El Sayed Zaki, Aman Yesuf Endries, Eduarda Fernandes, Florian Fischer, Joseph Frostad, Nancy Fullman, William M Gardner, Birhanu Geta, Keyghobad Ghadiri, Giuseppe Gorini, Alessandra C Goulart, Yuming Guo, Gessessew Bugssa Hailu, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Hamid Yimam Hassen, Chi Linh Hoang, Nobuyuki Horita, Mihaela Hostiuc, Zakir Hussain, Seyed Sina Naghibi Irvani, Spencer L James, Ravi Prakash Jha, Jost B Jonas, André Karch, Amir Kasaeian, Tesfaye Dessale Kassa, Nicholas J Kassebaum, Adane Teshome Kefale, Yousef Saleh Khader, Ejaz Ahmad Khan, Gulfaraz Khan, Md Nuruzzaman Khan, Young-Ho Khang, Abdullah T Khoja, Ruth W Kimokoti, Adnan Kisa, Sezer Kisa, Niranjan Kissoon, Luke D Knibbs, Sonali Kochhar, Soewarta Kosen, Parvaiz A Koul, Ai Koyanagi, Barthelemy Kuate Defo, G Anil Kumar, Dharmesh Kumar Lal, Cheru Tesema Leshargie, Sonia Lewycka, Shanshan Li, Rakesh Lodha, Erlyn Rachelle King Macarayan, Marek Majdan, Abdullah A Mamun, Helena Manguerra, Varshil Mehta, Addisu Melese, Ziad A Memish, Desalegn Tadese Mengistu, Tuomo J Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Erkin M Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Lorenzo Monasta, Catrin E Moore, Lidia Morawska, Jonathan F Mosser, Seyyed Meysam Mousavi, Srinivas Murthy, Ghulam Mustafa, Javad Nazari, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Long Hoang Nguyen, Son Hoang Nguyen, Katie R Nielsen, Muhammad Imran Nisar, Molly R Nixon, Felix Akpojene Ogbo, Anselm Okoro, Andrew T Olagunju, Tinuke O Olagunju, Eyal Oren, Justin R Ortiz, Mahesh P A, Smita Pakhale, Maarten J Postma, Mostafa Qorbani, Reginald Quansah, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Rajesh Kumar Rai, Marissa Bettay Reitsma, Mohammad Sadegh Rezai, Aziz Rezapour, Maria Jesus Rios-Blancas, Luca Ronfani, Dietrich Rothenbacher, Salvatore Rubino, Zikria Saleem, Evanson Zondani Sambala, Abdallah M Samy, Milena M Santric Milicevic, Rodrigo Sarmiento-Suárez, Benn Sartorius, Miloje Savic, Monika Sawhney, Sonia Saxena, Alyssa Sbarra, Seyedmojtaba Seyedmousavi, Masood Ali Shaikh, Aziz Sheikh, Mika Shigematsu, David L Smith, Chandrashekhar T Sreeramareddy, Jeffrey D Stanaway, Mu'awiyyah Babale Sufiyan, Mohamad-Hani Temsah, Belay Tessema, Bach Xuan Tran, Khanh Bao Tran, Afewerki Gebremeskel Tsadik, Irfan Ullah, Rachel L Updike, Tommi Juhani Vasankari, Yousef Veisani, Fiseha Wadilo Wada, Yasir Waheed, Katie Welgan, Kirsten E Wiens, Charles Shey Wiysonge, Ebrahim M Yimer, Naohiro Yonemoto, Zoubida Zaidi, Heather J Zar, Stephen S Lim, Theo Vos, Ali H Mokdad, Christopher J L Murray, Hmwe Hmwe Kyu, Simon I Hay, Robert C Reiner Lancet Infectious Diseases, 2020 Summary Background Despite large reductions in under-5 lower respiratory infection (LRI) mortality in many locations, the pace of progress for LRIs has generally lagged behind that of other childhood infectious diseases. To better inform programmes and policies focused on preventing and treating LRIs, we assessed the contributions and patterns of risk factor attribution, intervention coverage, and sociodemographic development in 195 countries and territories by drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) LRI estimates. Methods We used four strategies to model LRI burden: the mortality due to LRIs was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive ensemble modelling tool; the incidence of LRIs was modelled using population representative surveys, health-care utilisation data, and scientific literature in a compartmental meta-regression tool; the attribution of risk factors for LRI mortality was modelled in a counterfactual framework; and trends in LRI mortality were analysed applying changes in exposure to risk factors over time. In GBD, infectious disease mortality, including that due to LRI, is among HIV-negative individuals. We categorised locations based on their burden in 1990 to make comparisons in the changing burden between 1990 and 2017 and evaluate the relative percent change in mortality rate, incidence, and risk factor exposure to explain differences in the health loss associated with LRIs among children younger than 5 years. Findings In 2017, LRIs caused 808 920 deaths (95% uncertainty interval 747 286–873 591) in children younger than 5 years. Since 1990, there has been a substantial decrease in the number of deaths (from 2 337 538 to 808 920 deaths; 65·4% decrease, 61·5–68·5) and in mortality rate (from 362·7 deaths [330·1–392·0] per 100 000 children to 118·9 deaths [109·8–128·3] per 100 000 children; 67·2% decrease, 63·5–70·1). LRI incidence declined globally (32·4% decrease, 27·2–37·5). The percent change in under-5 mortality rate and incidence has varied across locations. Among the risk factors assessed in this study, those responsible for the greatest decrease in under-5 LRI mortality between 1990 and 2017 were increased coverage of vaccination against Haemophilus influenza type b (11·4% decrease, 0·0–24·5), increased pneumococcal vaccine coverage (6·3% decrease, 6·1–6·3), and reductions in household air pollution (8·4%, 6·8–9·2). Interpretation Our findings show that there have been substantial but uneven declines in LRI mortality among countries between 1990 and 2017. Although improvements in indicators of sociodemographic development could explain some of these trends, changes in exposure to modifiable risk factors are related to the rates of decline in LRI mortality. No single intervention would universally accelerate reductions in health loss associated with LRIs in all settings, but emphasising the most dominant risk factors, particularly in countries with high case fatality, can contribute to the reduction of preventable deaths. Funding Bill & Melinda Gates Foundation.
Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017 Christopher E Troeger, Ibrahim A. Khalil, Brigette F. Blacker, Molly H. Biehl, Samuel B. Albertson, Stephanie R M Zimsen, Puja C Rao, Degu Abate, Alireza Ahmadi, Mohamed Lemine Cheikh brahim Ahmed, Chalachew Genet Akal, Fares Alahdab, Noore Alam, Kefyalew Addis Alene, Vahid Alipour, Syed Mohamed Aljunid, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Saeed Amini, Nahla Hamed Anber, Mina Anjomshoa, Carl Abelardo T. Antonio, Jalal Arabloo, Olatunde Aremu, Hagos Tasew Atalay, Suleman Atique, Euripide F G A Avokpaho, Samah Awad, Ashish Awasthi, Alaa Badawi, Kalpana Balakrishnan, Joseph Adel Mattar Banoub, Aleksandra Barac, Quique Bassat, Neeraj Bedi, Derrick A. Bennett, Krittika Bhattacharyya, Zulfiqar A Bhutta, Ali Bijani, Josip Car, Félix Carvalho, Carlos A Castañeda-Orjuela, Devasahayam J Christopher, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Feleke Mekonnen Demeke, Aniruddha Deshpande, Shirin Djalalinia, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, Maysaa El Sayed Zaki, Aman Yesuf Endries, Eduarda Fernandes, Florian Fischer, Nancy Fullman, William M. Gardner, Birhanu Geta, Keyghobad Ghadiri, Giuseppe Gorini, Alessandra C Goulart, Yuming Guo, Gessessew Bugssa Hailu, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Hamid Yimam Hassen, Chi Linh Hoang, Mihaela Hostiuc, Zakir Hussain, Seyed Sina Naghibi Irvani, Spencer L. James, Ravi Prakash Jha, Jost B. Jonas, André Karch, Amir Kasaeian, Tesfaye Dessale Kassa, Nicholas J Kassebaum, Adane Teshome Kefale, Yousef Saleh Khader, Ejaz Ahmad Khan, Md Nuruzzaman Khan, Young-Ho Khang, Abdullah T Khoja, Ruth W Kimokoti, Adnan Kisa, Sezer Kisa, Niranjan Kissoon, Sonali Kochhar, Soewarta Kosen, Ai Koyanagi, Barthelemy Kuate Defo, G Anil Kumar, Dharmesh Kumar Lal, Cheru Tesema Leshargie, Shanshan Li, Rakesh Lodha, Erlyn Rachelle King Macarayan, Marek Majdan, Abdullah A. Mamun, Helena Manguerra, Addisu Melese, Ziad A Memish, Desalegn Tadese Mengistu, Tuomo J Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Erkin M Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Lorenzo Monasta, Catrin E Moore, Jonathan F. Mosser, Seyyed Meysam Mousavi, Srinivas Murthy, Ghulam Mustafa, Javad Nazari, Cuong Tat Nguyen, Long Hoang Nguyen, Muhammad Imran Nisar, Molly R Nixon, Felix Akpojene Ogbo, Anselm Okoro, Andrew T Olagunju, Tinuke O Olagunju, Mahesh P A, Smita Pakhale, Maarten J Postma, Mostafa Qorbani, Reginald Quansah, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Rajesh Kumar Rai, Mohammad Sadegh Rezai, Aziz Rezapour, Maria Jesus Rios-Blancas, Luca Ronfani, Katherine Rosettie, Dietrich Rothenbacher, Saeed Safari, Zikria Saleem, Evanson Zondani Sambala, Abdallah M. Samy, Milena M Santric Milicevic, Benn Sartorius, Monika Sawhney, Seyedmojtaba Seyedmousavi, Masood Ali Shaikh, Aziz Sheikh, Mika Shigematsu, David L Smith, Joan B Soriano, Chandrashekhar T Sreeramareddy, Jeffrey D Stanaway, Mu'awiyyah Babale Sufiyan, Teklay G E Teklu, Mohamad-Hani Temsah, Belay Tessema, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Rachel L Updike, Tommi Juhani Vasankari, Yousef Veisani, Fiseha Wadilo Wada, Yasir Waheed, Marcia Weaver, Kirsten E Wiens, Charles Shey Wiysonge, Ebrahim M Yimer, Naohiro Yonemoto, Zoubida Zaidi, Heather J Zar, Afshin Zarghi, Stephen S Lim, Theo Vos, Ali H Mokdad, Christopher J L Murray, Hmwe Hmwe Kyu, Simon I. Hay, Robert C Reiner Lancet Infectious Diseases, 2020
Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 Catherine Owens Johnson, Minh Nguyen, Gregory A Roth, Emma Nichols, Tahiya Alam, Degu Abate, Foad Abd-Allah, Ahmed Abdelalim, Haftom Niguse Abraha, Niveen ME Abu-Rmeileh, Oladimeji M Adebayo, Abiodun Moshood Adeoye, Gina Agarwal, Sutapa Agrawal, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Fares Alahdab, Raghib Ali, Nelson Alvis-Guzman, Nahla Hamed Anber, Mina Anjomshoa, Jalal Arabloo, Antonio Arauz, Johan Ärnlöv, Amit Arora, Ashish Awasthi, Maciej Banach, Miguel A Barboza, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Sanjay Basu, Abate Bekele Belachew, Yaschilal Muche Belayneh, Derrick A. Bennett, Isabela M Bensenor, Krittika Bhattacharyya, Belete Biadgo, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Zahid A Butt, Lucero Cahuana-Hurtado, Juan J Carrero, Félix Carvalho, Carlos A Castañeda-Orjuela, Franz Castro, Ferrán Catalá-López, Yazan Chaiah, Peggy Pei-Chia Chiang, Jee-Young J Choi, Hanne Christensen, Dinh-Toi Chu, Monica Cortinovis, Albertino Antonio Moura Damasceno, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Kairat Davletov, Barbora de Courten, Vanessa De la Cruz-Góngora, Meaza Girma Degefa, Samath Dhamminda Dharmaratne, Daniel Diaz, Manisha Dubey, Eyasu Ejeta Duken, Dumessa Edessa, Matthias Endres, EMERITO JOSE A FARAON, Farshad Farzadfar, Eduarda Fernandes, Florian Fischer, Luisa Sorio Flor, Morsaleh Ganji, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Birhanu Geta, Kebede Embaye Gezae, Paramjit Singh Gill, Elena V. Gnedovskaya, Hector Gómez-Dantés, Alessandra C Goulart, Giuseppe Grosso, Yuming Guo, Rajeev Gupta, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Graeme J. Hankey, Hamid Yimam Hassen, Simon I. Hay, Mohamed I Hegazy, Behnam Heidari, Nabeel A Herial, Mohammad Ali Hosseini, Sorin Hostiuc, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Nader Jahanmehr, Mehdi Javanbakht, Ravi Prakash Jha, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jürisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, André Karch, Narges Karimi, Hamidreza Karimi-Sari, Amir Kasaeian, Tesfaye Dessale Kassa, Hossein Kazemeini, Adane Teshome Kefale, Yousef Saleh Khader, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Jagdish Khubchandani, Daniel Kim, Yun Jin Kim, Adnan Kisa, Mika Kivimäki, Ai Koyanagi, Rita K Krishnamurthi, G Anil Kumar, Alessandra Lafranconi, Sarah Lewington, Shanshan Li, Warren David Lo, Alan D Lopez, Stefan Lorkowski, Paulo A. Lotufo, Mark T Mackay, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Navid Manafi, Mohammad Ali Mansournia, Man Mohan Mehndiratta, Varshil Mehta, Getnet Mengistu, Atte Meretoja, Tuomo J Meretoja, Bartosz Miazgowski, Tomasz Miazgowski, Ted R Miller, Erkin M Mirrakhimov, Bahram Mohajer, Yousef Mohammad, Milad Mohammadoo-khorasani, Shafiu Mohammed, Farnam Mohebi, Ali H Mokdad, Yaser Mokhayeri, Ghobad Moradi, Lidia Morawska, Ilais Moreno Velásquez, Seyyed Meysam Mousavi, Oumer Sada S Muhammed, Walter Muruet, Mehdi Naderi, Mohsen Naghavi, Gurudatta Naik, Bruno Ramos Nascimento, Ruxandra Irina Negoi, Cuong Tat Nguyen, Long Hoang Nguyen, Yirga Legesse Nirayo, Bo Norrving, Jean Jacques Noubiap, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T Olagunju, Tinuke O Olagunju, Mayowa Ojo Owolabi, Jeyaraj Durai Pandian, Shanti Patel, Norberto Perico, Michael A Piradov, Suzanne Polinder, Maarten J Postma, Hossein Poustchi, V Prakash, Mostafa Qorbani, Alireza Rafiei, Fakher Rahim, Kazem Rahimi, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Muhammad Aziz Rahman, Cesar Reis, Giuseppe Remuzzi, Andre M.N. Renzaho, Stefano Ricci, Nicholas L S Roberts, Stephen R Robinson, Leonardo Roever, Gholamreza Roshandel, Parisa Sabbagh, Hosein Safari, Saeed Safari, Saeid Safiri, Amirhossein Sahebkar, Saleh Salehi Zahabi, Abdallah M. Samy, Paola Santalucia, Itamar S Santos, João Vasco Santos, Milena M Santric Milicevic, Benn Sartorius, Arundhati R Sawant, Aletta Elisabeth Schutte, Sadaf G. Sepanlou, Azadeh Shafieesabet, Masood Ali Shaikh, Mehran Shams-Beyranvand, Aziz Sheikh, Kevin N. Sheth, Kenji Shibuya, Mika Shigematsu, Min-Jeong Shin, Ivy Shiue, Soraya Siabani, Badr Hasan Sobaih, Luciano A. Sposato, Ipsita Sutradhar, PN Sylaja, Cassandra E I Szoeke, Braden James Te Ao, Mohamad-Hani Temsah, Omar Temsah, Amanda G Thrift, Marcello Tonelli, Roman Topor-Madry, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Irfan Ullah, Olalekan A Uthman, Muthiah Vaduganathan, Pascual R Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Narayanaswamy Venketasubramanian, Kia Vosoughi, Giang Thu Vu, Yasir Waheed, Elisabete Weiderpass, Kidu Gidey Weldegwergs, Ronny Westerman, Charles D A Wolfe, Dawit Zewdu Wondafrash, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Hiroshi Yatsuya, Ebrahim M Yimer, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Mohammad Zamani, Afshin Zarghi, Yunquan Zhang, Sanjay Zodpey, Valery L. Feigin, Theo Vos, Christopher J L Murray Lancet Neurology, 2019
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-Venning, Minh Nguyen, Richard Ofori-Asenso, Anoop P Patel, Marco Piccininni, Gregory A Roth, Timothy J Steiner, Lars Jacob Stovner, Cassandra E I Szoeke, Alice Theadom, Stein Emil Vollset, Mitchell Taylor Wallin, Claire Wright, Joseph Raymond Zunt, Nooshin Abbasi, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Victor Aboyans, Haftom Niguse Abraha, Dilaram Acharya, Abdu A Adamu, Oladimeji M Adebayo, Abiodun Moshood Adeoye, Jose C Adsuar, Mohsen Afarideh, Sutapa Agrawal, Alireza Ahmadi, Muktar Beshir Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Rufus Olusola Akinyemi, Nadia Akseer, Ayman Al-Eyadhy, Rustam Al-Shahi Salman, Fares Alahdab, Kefyalew Addis Alene, Syed Mohamed Aljunid, Khalid Altirkawi, Nelson Alvis-Guzman, Nahla Hamed Anber, Carl Abelardo T Antonio, Jalal Arabloo, Olatunde Aremu, Johan Ärnlöv, Hamid Asayesh, Rana Jawad Asghar, Hagos Tasew Atalay, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Tambe B Ayuk, Alaa Badawi, Maciej Banach, Joseph Adel Mattar Banoub, Miguel A Barboza, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Bernhard T Baune, Neeraj Bedi, Masoud Behzadifar, Meysam Behzadifar, Yannick Béjot, Bayu Begashaw Bekele, Abate Bekele Belachew, Derrick A Bennett, Isabela M Bensenor, Adugnaw Berhane, Mircea Beuran, Krittika Bhattacharyya, Zulfiqar A Bhutta, Belete Biadgo, Ali Bijani, Nigus Bililign, Muhammad Shahdaat Bin Sayeed, Christopher Kynrint Blazes, Carol Brayne, Zahid A Butt, Ismael R Campos-Nonato, Carlos Cantu-Brito, Mate Car, Rosario Cárdenas, Juan J Carrero, Félix Carvalho, Carlos A Castañeda-Orjuela, Franz Castro, Ferrán Catalá-López, Ester Cerin, Yazan Chaiah, Jung-Chen Chang, Irini Chatziralli, Peggy Pei-Chia Chiang, Hanne Christensen, Devasahayam J Christopher, Cyrus Cooper, Paolo Angelo Cortesi, Vera M Costa, Michael H Criqui, Christopher Stephen Crowe, Albertino Antonio Moura Damasceno, Ahmad Daryani, Vanessa De la Cruz-Góngora, Fernando Pio De la Hoz, Diego De Leo, Gebre Teklemariam Demoz, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Mesfin Tadese Dinberu, Shirin Djalalinia, David Teye Doku, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, David Edvardsson, Ziad El-Khatib, Matthias Endres, Aman Yesuf Endries, Sharareh Eskandarieh, Alireza Esteghamati, Sadaf Esteghamati, Farzaneh Farhadi, Andre Faro, Farshad Farzadfar, Mohammad Hosein Farzaei, Batool Fatima, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Garumma Tolu Feyissa, Irina Filip, Florian Fischer, Takeshi Fukumoto, Morsaleh Ganji, Fortune Gbetoho Gankpe, Miguel A Garcia-Gordillo, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Belayneh K Gelaw, Johanna M Geleijnse, Demeke Geremew, Kebede Embaye Gezae, Maryam Ghasemi-Kasman, Mahari Y Gidey, Paramjit Singh Gill, Tiffany K Gill, Efrata Tufa Girma, Elena V Gnedovskaya, Alessandra C Goulart, Ayman Grada, Giuseppe Grosso, Yuming Guo, Rahul Gupta, Rajeev Gupta, Juanita A Haagsma, Tekleberhan B Hagos, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R Hamadeh, Samer Hamidi, Graeme J Hankey, Yuantao Hao, Josep Maria Haro, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Simon I Hay, Mohamed I Hegazy, Behnam Heidari, Andualem Henok, Fatemeh Heydarpour, Chi Linh Hoang, Michael K Hole, Enayatollah Homaie Rad, Seyed Mostafa Hosseini, Guoqing Hu, Ehimario U Igumbor, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Mihajlo Jakovljevic, Mehdi Javanbakht, Ravi Prakash Jha, Yash B Jobanputra, Jost B Jonas, Jacek Jerzy Jozwiak, Mikk Jürisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Manoochehr Karami, André Karch, Narges Karimi, Amir Kasaeian, Tesfaye Dessale Kassa, Zemenu Yohannes Kassa, Anil Kaul, Adane Teshome Kefale, Peter Njenga Keiyoro, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Ibrahim A Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Habibolah Khazaie, Aliasghar A Kiadaliri, Daniel N Kiirithio, Anthony S Kim, Daniel Kim, Young-Eun Kim, Yun Jin Kim, Adnan Kisa, Yoshihiro Kokubo, Ai Koyanagi, Rita V Krishnamurthi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Manasi Kumar, Ben Lacey, Alessandra Lafranconi, Van C Lansingh, Arman Latifi, Cheru Tesema Leshargie, Shanshan Li, Yu Liao, Shai Linn, Warren David Lo, Jaifred Christian F Lopez, Stefan Lorkowski, Paulo A Lotufo, Robyn M Lucas, Raimundas Lunevicius, Mark T Mackay, Narayan Bahadur Mahotra, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Navid 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Mohammad, Noushin Mohammadifard, Shafiu Mohammed, Lorenzo Monasta, Paula Moraga, Lidia Morawska, Seyyed Meysam Mousavi, Satinath Mukhopadhyay, Kamarul Imran Musa, Aliya Naheed, Gurudatta Naik, Farid Najafi, Vinay Nangia, Jobert Richie Nansseu, Mudavath Siva Durga Prasad Nayak, Chakib Nejjari, Subas Neupane, Sudan Prasad Neupane, Josephine W Ngunjiri, Cuong Tat Nguyen, Long Hoang Nguyen, Trang Huyen Nguyen, Dina Nur Anggraini Ningrum, Yirga Legesse Nirayo, Jean Jacques Noubiap, Richard Ofori-Asenso, Felix Akpojene Ogbo, In-Hwan Oh, Olanrewaju Oladimeji, Andrew T Olagunju, Pedro R Olivares, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Anu Mary Oommen, Eyal Oren, Heather M Orpana, Doris D V Ortega-Altamirano, Justin R Ortiz, Erika Ota, Mayowa Ojo Owolabi, Abayomi Samuel Oyekale, Mahesh P A, Adrian Pana, Eun-Kee Park, Charles D H Parry, Hadi Parsian, Ajay Patle, George C Patton, Deepak Paudel, Max Petzold, Michael R Phillips, Julian David Pillay, Maarten J Postma, Farshad Pourmalek, Dorairaj Prabhakaran, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Alireza Rafiei, Fakher Rahim, Afarin Rahimi-Movaghar, Mahfuzar Rahman, Muhammad Aziz Rahman, Rajesh Kumar Rai, Sasa Rajsic, Sree Bhushan Raju, Usha Ram, Saleem M Rana, Chhabi Lal Ranabhat, David Laith Rawaf, Salman Rawaf, Robert C Reiner, Cesar Reis, Andre M N Renzaho, Mohammad Sadegh Rezai, Leonardo Roever, Luca Ronfani, Robin Room, Gholamreza Roshandel, Ali Rostami, Gregory A Roth, Ambuj Roy, Yogesh Damodar Sabde, Basema Saddik, Saeid Safiri, Amirhossein Sahebkar, Joseph S Salama, Zikria Saleem, Joshua A Salomon, Sundeep Santosh Salvi, Juan Sanabria, Maria Dolores Sanchez-Niño, Damian Francesco Santomauro, Itamar S Santos, Milena M M Santric Milicevic, Abdur Razzaque Sarker, Rodrigo Sarmiento-Suárez, Nizal Sarrafzadegan, Benn Sartorius, Maheswar Satpathy, Monika Sawhney, Sonia Saxena, Mete Saylan, Michael P Schaub, Maria Inês Schmidt, Ione J C Schneider, Ben Schöttker, Aletta Elisabeth Schutte, Falk Schwendicke, Sadaf G Sepanlou, Masood Ali Shaikh, Mehdi Sharif, Jun She, Aziz Sheikh, Jiabin Shen, Mekonnen Sisay Shiferaw, Mika Shigematsu, Rahman Shiri, Kawkab Shishani, Ivy Shiue, Sharvari Rahul Shukla, Inga Dora Sigfusdottir, Diego Augusto Santos Silva, Natacha Torres Da Silva, Dayane Gabriele Alves Silveira, Dhirendra Narain Sinha, Freddy Sitas, Adauto Martins Soares Filho, Moslem Soofi, Reed J D Sorensen, Joan B Soriano, Chandrashekhar T Sreeramareddy, Nadine Steckling, Dan J Stein, Mu'awiyyah Babale Sufiyan, Patrick J Sur, Bryan L Sykes, Rafael Tabarés-Seisdedos, Takahiro Tabuchi, Mohammad Tavakkoli, Arash Tehrani-Banihashemi, Merhawi Gebremedhin Tekle, Subash Thapa, Nihal Thomas, Roman Topor-Madry, Fotis Topouzis, Bach Xuan Tran, Christopher E Troeger, Thomas Clement Truelsen, Nikolaos Tsilimparis, Stefanos Tyrovolas, Kingsley Nnanna Ukwaja, Irfan Ullah, Olalekan A Uthman, Pascual R Valdez, Job F M Van Boven, Tommi Juhani Vasankari, Narayanaswamy Venketasubramanian, Francesco S Violante, Sergey Konstantinovitch Vladimirov, Vasily Vlassov, Stein Emil Vollset, Theo Vos, Fasil Wagnew Shiferaw Wagnew, Yasir Waheed, Yuan-Pang Wang, Elisabete Weiderpass, Fitsum Weldegebreal, Kidu Gidey Weldegwergs, Andrea Werdecker, Ronny Westerman, Harvey A Whiteford, Justyna Widecka, Tissa Wijeratne, Grant M A Wyper, Gelin Xu, Tomohide Yamada, Yuichiro Yano, Pengpeng Ye, Ebrahim M Yimer, Paul Yip, Biruck Desalegn Yirsaw, Engida Yisma, Naohiro Yonemoto, Seok-Jun Yoon, Marcel Yotebieng, Mustafa Z Younis, Geevar Zachariah, Zoubida Zaidi, Mohammad Zamani, Xueying Zhang, Sanjay Zodpey, Ali H Mokdad, Mohsen Naghavi, Christopher J L Murray, Emmanuela Gakidou Lancet, 2018
Ethnopharmacological Assessment of Cyathea manniana Hook: Antifertility Activity and Acute Toxicity in Swiss Albino Rats NE Dabe, MA Kebede, AB Tekle, TL Dadi, HT Afework, AT Kefale, ... 2025
Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves of Prunus africana -using mice model NE Dabe, AT Kefale, HA Addo, TW Dido, MS Kedir, HT Afework, ... Biorxiv, 2024.04. 11.588968 , 2024 2024 Citations: 2
Oral anticoagulant use in patients with atrial fibrillation at low risk of stroke and associated bleeding complications AT Kefale, WM Bezabhe, GM Peterson Journal of Clinical Medicine 12 (19), 6182 , 2023 2023 Citations: 8
Clinical outcomes of oral anticoagulant discontinuation in atrial fibrillation: a systematic review and meta-analysis AT Kefale, WM Bezabhe, GM Peterson Expert Review of Clinical Pharmacology 16 (7), 677-684 , 2023 2023 Citations: 2
Oral anticoagulant discontinuation and its predictors in patients with atrial fibrillation AT Kefale, WM Bezabhe, GM Peterson Journal of Clinical Medicine 11 (20), 6022 , 2022 2022 Citations: 5
Switching of oral anticoagulants in atrial fibrillation: a cohort study using Australian general practice data AT Kefale, GM Peterson, WM Bezabhe, LR Bereznicki Expert Review of Clinical Pharmacology 15 (3), 351-357 , 2022 2022 Citations: 6
Switching of oral anticoagulants in patients with nonvalvular atrial fibrillation: A narrative review AT Kefale, GM Peterson, WM Bezabhe, LR Bereznicki British Journal of Clinical Pharmacology 88 (2), 514-534 , 2022 2022 Citations: 15
Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia A Desta, TT Biru, AT Kefale PloS one 15 (8), e0237013 , 2020 2020 Citations: 50
Evaluation of Abortifacient Effect of Rumex nepalensis Spreng Among Pregnant Swiss Albino Rats: Laboratory-Based Study NE Dabe, AT Kefale, TL Dadi Journal of Experimental Pharmacology, 255-265 , 2020 2020 Citations: 17
Appropriateness of insulin commencement and adequacy of glycemic control among ambulatory patients with type 2 diabetes in Ethiopia AT Kefale, TT Biru, HA Addo Journal of Diabetes & Metabolic Disorders 18 (2), 461-469 , 2019 2019 Citations: 6
Availability of essential medicines and pharmaceutical inventory management practice at health centers of Adama town, Ethiopia AT Kefale, HH Shebo BMC health services research 19 (1), 254 , 2019 2019 Citations: 102
Treatment outcome and adverse events of tenofovir disoproxil fumarate based regimens as compared to zidovudine based regimens among people living with HIV/AIDS: a systematic … AT Kefale, TL Dadi, TT Biru, TA Mega The Open AIDS Journal 12, 38 , 2018 2018 Citations: 6
Outcome of tuberculosis treatment and its predictors among HIV infected patients in southwest Ethiopia A Teshome Kefale, YK Anagaw International journal of general medicine, 161-169 , 2017 2017 Citations: 45
Antidiabetic effects of artemisia species: a systematic review NE Dabe, AT Kefale Ancient science of life 36 (4), 175-181 , 2017 2017 Citations: 51
Knowledge, attitude and practice of healthcare professionals towards adverse drug reaction reporting at inpatient wards of tertiary hospital, Ethiopia AT Kefale, BD Tefera, TT Biru Journal of Drug Delivery and Therapeutics 7 (4), 97-102 , 2017 2017 Citations: 12
Efficacy and Tolerability of Tenofovir Disoproxil Fumarate Based Regimen as Compared to Zidovudine Based Regimens: A Systematic Review and Meta‐Analysis TL Dadi, AT Kefale, TA Mega, MS Kedir, HA Addo, TT Biru AIDS research and treatment 2017 (1), 5792925 , 2017 2017 Citations: 25
Clients’ perception and satisfaction toward service provided by pharmacy professionals at a teaching hospital in Ethiopia A Teshome Kefale, G Hagos Atsebah, T Ayele Mega Integrated Pharmacy Research and Practice, 85-94 , 2016 2016 Citations: 45
Hospitalization pattern and treatment outcome among diabetic patients admitted to a teaching Hospital in Ethiopia: a prospective observational study AT Kefale, TC Eshetie, EK Gudina J Health Med Nurs 28, 34-41 , 2016 2016 Citations: 23
MOST CITED SCHOLAR PUBLICATIONS
Availability of essential medicines and pharmaceutical inventory management practice at health centers of Adama town, Ethiopia AT Kefale, HH Shebo BMC health services research 19 (1), 254 , 2019 2019 Citations: 102
Antidiabetic effects of artemisia species: a systematic review NE Dabe, AT Kefale Ancient science of life 36 (4), 175-181 , 2017 2017 Citations: 51
Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia A Desta, TT Biru, AT Kefale PloS one 15 (8), e0237013 , 2020 2020 Citations: 50
Outcome of tuberculosis treatment and its predictors among HIV infected patients in southwest Ethiopia A Teshome Kefale, YK Anagaw International journal of general medicine, 161-169 , 2017 2017 Citations: 45
Clients’ perception and satisfaction toward service provided by pharmacy professionals at a teaching hospital in Ethiopia A Teshome Kefale, G Hagos Atsebah, T Ayele Mega Integrated Pharmacy Research and Practice, 85-94 , 2016 2016 Citations: 45
Efficacy and Tolerability of Tenofovir Disoproxil Fumarate Based Regimen as Compared to Zidovudine Based Regimens: A Systematic Review and Meta‐Analysis TL Dadi, AT Kefale, TA Mega, MS Kedir, HA Addo, TT Biru AIDS research and treatment 2017 (1), 5792925 , 2017 2017 Citations: 25
Hospitalization pattern and treatment outcome among diabetic patients admitted to a teaching Hospital in Ethiopia: a prospective observational study AT Kefale, TC Eshetie, EK Gudina J Health Med Nurs 28, 34-41 , 2016 2016 Citations: 23
Evaluation of Abortifacient Effect of Rumex nepalensis Spreng Among Pregnant Swiss Albino Rats: Laboratory-Based Study NE Dabe, AT Kefale, TL Dadi Journal of Experimental Pharmacology, 255-265 , 2020 2020 Citations: 17
Switching of oral anticoagulants in patients with nonvalvular atrial fibrillation: A narrative review AT Kefale, GM Peterson, WM Bezabhe, LR Bereznicki British Journal of Clinical Pharmacology 88 (2), 514-534 , 2022 2022 Citations: 15
Knowledge, attitude and practice of healthcare professionals towards adverse drug reaction reporting at inpatient wards of tertiary hospital, Ethiopia AT Kefale, BD Tefera, TT Biru Journal of Drug Delivery and Therapeutics 7 (4), 97-102 , 2017 2017 Citations: 12
Oral anticoagulant use in patients with atrial fibrillation at low risk of stroke and associated bleeding complications AT Kefale, WM Bezabhe, GM Peterson Journal of Clinical Medicine 12 (19), 6182 , 2023 2023 Citations: 8
Switching of oral anticoagulants in atrial fibrillation: a cohort study using Australian general practice data AT Kefale, GM Peterson, WM Bezabhe, LR Bereznicki Expert Review of Clinical Pharmacology 15 (3), 351-357 , 2022 2022 Citations: 6
Appropriateness of insulin commencement and adequacy of glycemic control among ambulatory patients with type 2 diabetes in Ethiopia AT Kefale, TT Biru, HA Addo Journal of Diabetes & Metabolic Disorders 18 (2), 461-469 , 2019 2019 Citations: 6
Treatment outcome and adverse events of tenofovir disoproxil fumarate based regimens as compared to zidovudine based regimens among people living with HIV/AIDS: a systematic … AT Kefale, TL Dadi, TT Biru, TA Mega The Open AIDS Journal 12, 38 , 2018 2018 Citations: 6
Oral anticoagulant discontinuation and its predictors in patients with atrial fibrillation AT Kefale, WM Bezabhe, GM Peterson Journal of Clinical Medicine 11 (20), 6022 , 2022 2022 Citations: 5
Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves of Prunus africana -using mice model NE Dabe, AT Kefale, HA Addo, TW Dido, MS Kedir, HT Afework, ... Biorxiv, 2024.04. 11.588968 , 2024 2024 Citations: 2
Clinical outcomes of oral anticoagulant discontinuation in atrial fibrillation: a systematic review and meta-analysis AT Kefale, WM Bezabhe, GM Peterson Expert Review of Clinical Pharmacology 16 (7), 677-684 , 2023 2023 Citations: 2
Ethnopharmacological Assessment of Cyathea manniana Hook: Antifertility Activity and Acute Toxicity in Swiss Albino Rats NE Dabe, MA Kebede, AB Tekle, TL Dadi, HT Afework, AT Kefale, ... 2025
