My research focuses on the characterization of molecular, cellular, and microbial dysregulations in autoimmune and autoinflammatory disorders, at both steady state and in response to immunotherapies, using systems immunology approaches.
RESEARCH, TEACHING, or OTHER INTERESTS
Immunology
3257
Scholar Citations
28
Scholar h-index
65
Scholar i10-index
RECENT SCHOLAR PUBLICATIONS
Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis M Binvignat, J Dubois, MM Salvador, P Stys, F Pitoiset, A Roux, M Sastre, ... ARTHRITIS & RHEUMATOLOGY , 2026 2026
Immune checkpoint-engineered virus-like particles induce antigen-specific immune tolerance and protect against food allergy PA Vinot, J Vigneron, J Marsande, B Levacher, N Tchitchek, D Klatzmann, ... npj Vaccines , 2026 2026
Prognostic factors and predictive model for severe multiple sclerosis at first onset in a pediatric French cohort A de Chalus, G Barraza, N Tchitchek, Y Debza, H Maurey, B Husson, ... European Journal of Paediatric Neurology , 2025 2025
Interactions entre cellules MAIT et microbiome dans la polyarthrite rhumatoïde M Lesturgie-Talarek, G Kvedaraviciute, E Mariotti-Ferrandiz, D Klatzmann, ... Revue du Rhumatisme 92, A56-A57 , 2025 2025
Transcriptomic module fingerprint reveals heterogeneity of whole blood transcriptome in type 1 diabetic patients FL Valentim, O Konza, A Velasquez, A Saadawi, N Patel, R Lorenzon, ... bioRxiv, 2025.11. 19.689306 , 2025 2025
Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis M Binvignat, J Dubois, M Marco Salvador, P Stys, F Pitoiset, A Roux, ... Arthritis & Rheumatology , 2025 2025 Citations: 1
AnalyzAIRR: A user-friendly guided workflow for AIRR data analysis V Mhanna, G Pires, G Bohl-Viallefond, K El Soufi, N Tchitchek, ... ImmunoInformatics 19, 100052 , 2025 2025 Citations: 5
BLIMP-1 and CEACAM1 cooperatively regulate human Treg homeostasis and function to control xenogeneic GVHD Y Ding, A Yu, M Vujanac, SN Copsel, A Moro, L Nivelo, M Dalzell, ... JCI insight 10 (18), e183676 , 2025 2025 Citations: 1
Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models J Robert, M Feuillolay, M de Temple-Llavero, RF Akossi, V Mhanna, ... Nature Communications 16 (1), 4891 , 2025 2025 Citations: 10
IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues R Vaineau, R Jeger-Madiot, S Ali-Moussa, L Prudhomme, H Debarnot, ... JCI insight 10 (12), e188724 , 2025 2025 Citations: 8
Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype P Ellul, G Fourcade, V Mhanna, N Coatnoan, S Bodula, D Seilhean, ... bioRxiv, 2025.01. 06.631430 , 2025 2025 Citations: 4
Low-dose interleukin-2 in patients with bipolar depression: a phase 2 randomised double-blind placebo-controlled trial M Leboyer, M Foiselle, N Tchitchek, R Tamouza, R Lorenzon, JR Richard, ... Brain, Behavior, and Immunity 123, 177-184 , 2025 2025 Citations: 12
Signature immunologique de la gonarthrose: rôle des lymphocytes T régulateurs dans la douleur. Résultats de l’étude TRANSIMMUNOM M Binvignat, J Dubois, MM Savaldor, P Stys, F Pitoiset, A Roux, M Barbier, ... Revue du Rhumatisme 91, A125-A127 , 2024 2024
Immunological profiling in knee osteoarthritis: Treg dysfunction as key driver of pain M Binvignat, J Dubois, M Marco Salvador, P Stys, F Pitoiset, A Roux, ... bioRxiv, 2024.10. 12.618016 , 2024 2024 Citations: 3
POS0792 IMMUNOLOGICAL PROFILING OF PAIN IN KNEE OSTEOARTHRITIS: TREG CELLS AS POTENTIAL NEW KEY PLAYERS IN SYMPTOMATIC KNEE OSTEOARTHRITIS M Binvignat, J Dubois, N Tchitchek, M Rosenzwajg, M Barbier, F Pitoiset, ... Annals of the Rheumatic Diseases 83, 655-656 , 2024 2024
Interleukin-1 regulates follicular T cells during the germinal center reaction A Belbezier, P Engeroff, G Fourcade, H Vantomme, R Vaineau, B Gouritin, ... Frontiers in immunology 15, 1393096 , 2024 2024 Citations: 13
BLIMP-1 and CEACAM1 cooperate to regulate human regulatory T cell proliferation and function Y Ding, A Yu, M Vujanac, S Copsel, A Moro, L Nivelo, N Tchitchek, ... The Journal of Immunology 212 (1_Supplement), 0229_5060-0229_5060 , 2024 2024
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types N Tchitchek, M Binvignat, A Roux, F Pitoiset, J Dubois, G Marguerit, ... Annals of the Rheumatic Diseases 83 (5), 638-650 , 2024 2024 Citations: 18
Maternal immune activation during pregnancy is associated with more difficulties in socio-adaptive behaviors in autism spectrum disorder P Ellul, A Maruani, V Vantalon, E Humeau, A Amestoy, A Anchordoqui, ... Scientific Reports 13 (1), 17687 , 2023 2023 Citations: 20
Tissue-resident uterine regulatory T cells support fetal growth LM Florez, G Fourcade, G Darrassse-Jèze, P Barennes, ... bioRxiv, 2023.09. 07.554921 , 2023 2023 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea K Endt, B Stecher, S Chaffron, E Slack, N Tchitchek, A Benecke, ... PLoS pathogens 6 (9), e1001097 , 2010 2010 Citations: 443
Progenitors from the central nervous system drive neurogenesis in cancer P Mauffrey, N Tchitchek, V Barroca, AP Bemelmans, V Firlej, Y Allory, ... Nature 569 (7758), 672-678 , 2019 2019 Citations: 363
Salivary gland epithelial cells from patients with Sjögren's syndrome induce B-lymphocyte survival and activation E Rivière, J Pascaud, N Tchitchek, S Boudaoud, A Paoletti, B Ly, A Dupré, ... Annals of the rheumatic diseases 79 (11), 1468-1477 , 2020 2020 Citations: 133
Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study M Rosenzwajg, R Salet, R Lorenzon, N Tchitchek, A Roux, C Bernard, ... Diabetologia 63 (9), 1808-1821 , 2020 2020 Citations: 128
Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts L Josset, N Tchitchek, LE Gralinski, MT Ferris, AJ Eisfeld, RR Green, ... RNA biology 11 (7), 875-890 , 2014 2014 Citations: 126
Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial A Monsel, C Hauw-Berlemont, M Mebarki, N Heming, J Mayaux, ... Critical Care 26 (1), 48 , 2022 2022 Citations: 115
Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus P Roques, K Ljungberg, BM Kümmerer, L Gosse, N Dereuddre-Bosquet, ... JCI insight 2 (6), e83527 , 2017 2017 Citations: 112
Vaccine inoculation route modulates early immunity and consequently antigen-specific immune response P Rosenbaum, N Tchitchek, C Joly, A Rodriguez Pozo, L Stimmer, ... Frontiers in immunology 12, 645210 , 2021 2021 Citations: 96
A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses HD Mitchell, AJ Eisfeld, AC Sims, JE McDermott, MM Matzke, ... PloS one 8 (7), e69374 , 2013 2013 Citations: 84
Predictive markers of immunogenicity and efficacy for human vaccines M Van Tilbeurgh, K Lemdani, AS Beignon, C Chapon, N Tchitchek, ... Vaccines 9 (6), 579 , 2021 2021 Citations: 68
Interleukin‐7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren’s Syndrome E Rivière, J Pascaud, A Virone, A Dupré, B Ly, A Paoletti, R Seror, ... Arthritis & rheumatology 73 (4), 631-640 , 2021 2021 Citations: 63
Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition C Bécavin, N Tchitchek, C Mintsa-Eya, A Lesne, A Benecke Bioinformatics 27 (10), 1413-1421 , 2011 2011 Citations: 62
Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria F Herbert, N Tchitchek, D Bansal, J Jacques, S Pathak, C Bécavin, ... Journal of translational medicine 13 (1), 369 , 2015 2015 Citations: 59
Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses MJ Korth, N Tchitchek, AG Benecke, MG Katze Seminars in immunology 25 (3), 228-239 , 2013 2013 Citations: 57
2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models JT Go, SE Belisle, N Tchitchek, TM Tumpey, W Ma, JA Richt, D Safronetz, ... BMC genomics 13 (1), 627 , 2012 2012 Citations: 55
H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal … J Morrison, L Josset, N Tchitchek, J Chang, JA Belser, DE Swayne, ... Journal of virology 88 (18), 10556-10568 , 2014 2014 Citations: 52
Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination E Gonçalves, O Bonduelle, A Soria, P Loulergue, A Rousseau, ... The Journal of clinical investigation 129 (5), 1960-1971 , 2019 2019 Citations: 50
1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice T Watanabe, J Tisoncik-Go, N Tchitchek, S Watanabe, AG Benecke, ... Journal of virology 87 (9), 5239-5254 , 2013 2013 Citations: 50
Listeriomics: an Interactive Web Platform for Systems Biology of Listeria C Bécavin, M Koutero, N Tchitchek, F Cerutti, P Lechat, N Maillet, ... MSystems 2 (2), 10.1128/msystems. 00186-16 , 2017 2017 Citations: 48
A comprehensive collection of systems biology data characterizing the host response to viral infection BD Aevermann, BE Pickett, S Kumar, EB Klem, S Agnihothram, ... Scientific data 1 (1), 140033 , 2014 2014 Citations: 47
