laura colombo

Scopus Publications

Longitudinal and combined assessment of 24(S)-hydroxycholesterol and Neurofilament light chain in the early stages of Huntington's disease
Lidia Sarro, Marta Valenza, Alessia Mongelli, Alice Passoni, Anna Castaldo, Monica Favagrossa, Laura Pasetto, Valentina Bonetto, Renzo Bagnati, Marina Grisoli, Anna Nigri, Giulia Birolini, Elena Zerbini, Simone Tomè, Marco Masseroli, Erika Salvi, Laura Colombo, Mario Salmona, Elena Cattaneo, Caterina Mariotti
Neurobiology of Disease, 2026
Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder. Recent clinical research has focused on neurofilament light chain protein (NfL), and cholesterol metabolites as potential fluid biomarkers related to disease progression. Our aim was to explore whether the combined longitudinal assessment of NfL and cholesterol-derived metabolites would improve the characterization of early HD stages. We enrolled 96 HD individuals and 63 healthy controls. Disease stage of HD participants was determined using both the system based on Total Motor Score (TMS), and the new HD-Integrated Staging System (HD-ISS). Concentrations of plasma NfL, and cholesterol precursors and metabolites, were measured at baseline and 2-year follow-up. In premanifest individuals, classified according to TMS, we found significantly reduced 24(S)-hydroxycholesterol (24S-OHC), a metabolite entirely derived from brain cholesterol catabolism, and normal level of NfL. When applying the HD-ISS, 24S-OHC was significantly reduced in HD-ISS-1 (25.6 ± 7.6 ng/ml) and HD-ISS-3 (30.5 ± 15.7) compared with controls (39.5 ± 14.1). NfL was increased in HD-ISS-1 (16.1 ± 6.5 pg/ml), HD-ISS-2 (16.1 ± 6.5) and HD-ISS-3 (27.0 ± 6.9) compared with controls (5.5 ± 1.7 pg/ml). In HD-ISS-0, all biomarker concentrations were similar to those of controls. At follow-up, NfL increased in HD-ISS-1 (+20%; p < 0.005). ROC analyses showed that NfL discriminated HD-ISS-0 and HD-ISS-1 from controls. 24S-OHC distinguished HD-ISS-1 from controls. Plasma NfL and 24S-OHC concentrations provide complementary insights into early biological changes in HD, and holds the potential to characterize the transition phase from the pre-symptomatic to the early symptomatic stage.
Corrigendum to ‘Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease’ J Control Release. 2021 Feb 10;330:587–598 (Journal of Controlled Release (2021) 330 (587–598), (S0168365920307756), (10.1016/j.jconrel.2020.12.051))
Giulia Birolini, Marta Valenza, Ilaria Ottonelli, Alice Passoni, Monica Favagrossa, Jason T. Duskey, Mauro Bombaci, Maria Angela Vandelli, Laura Colombo, Renzo Bagnati, Claudio Caccia, Valerio Leoni, Franco Taroni, Flavio Forni, Barbara Ruozi, Mario Salmona, Giovanni Tosi, Elena Cattaneo
Journal of Controlled Release, 2025
Tau oligomers impair memory and synaptic plasticity through the cellular prion protein
C. Balducci, Franca Orsini, M. Cerović, M. Beeg, Beatrice Rocutto, L. Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, L. Colombo, C. Zucchelli, Giovanna Musco, N. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, G. Forloni
Acta Neuropathologica Communications, 2025
Deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in Alzheimer’s disease (AD) and other tauopathies. Among tau aggregates, oligomers (TauOs) are considered the most toxic. AD brains show significant increase in TauOs compared to healthy controls, their concentration correlating with the severity of cognitive deficits and disease progression. In vitro and in vivo neuronal TauO exposure leads to synaptic and cognitive dysfunction, but their mechanisms of action are unclear. Evidence suggests that the cellular prion protein (PrPC) may act as a mediator of TauO neurotoxicity, as previously proposed for β-amyloid and α-synuclein oligomers. To investigate whether PrPC mediates TauO detrimental activities, we compared their effects on memory and synaptic plasticity in wild type (WT) and PrPC knockout (Prnp0/0) mice. Intracerebroventricular injection of TauOs significantly impaired recognition memory in WT but not in Prnp0/0 mice. Similarly, TauOs inhibited long-term potentiation in acute hippocampal slices from WT but not Prnp0/0 mice. Surface plasmon resonance indicated a high-affinity binding between TauOs and PrPC with a KD of 20–50 nM. Immunofluorescence analysis of naïve and PrPC-overexpressing HEK293 cells exposed to TauOs showed a PrPC dose-dependent association of TauOs with cells over time, and their co-localization with PrPC on the plasma membrane and in intracellular compartments, suggesting PrPC-may play a role in TauO internalization. These findings support the concept that PrPC mediates the detrimental activities of TauOs through a direct interaction, suggesting that targeting this interaction might be a promising therapeutic strategy for AD and other tauopathies.
Corrigendum to “Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease” (Pharmacological Research (2023) 194, (S1043661823001792), (10.1016/j.phrs.2023.106823))
Giulia Birolini, Marta Valenza, Ilaria Ottonelli, Francesca Talpo, Lucia Minoli, Andrea Cappelleri, Mauro Bombaci, Claudio Caccia, Caterina Canevari, Arianna Trucco, Valerio Leoni, Alice Passoni, Monica Favagrossa, Maria Rosaria Nucera, Laura Colombo, Saverio Paltrinieri, Renzo Bagnati, Jason Thomas Duskey, Riccardo Caraffi, Maria Angela Vandelli, Franco Taroni, Mario Salmona, Eugenio Scanziani, Gerardo Biella, Barbara Ruozi, Giovanni Tosi, Elena Cattaneo
Pharmacological Research, 2025
“The authors would like to inform readers that, because of a clerical mistakes, the samples labeled as ‘striatum’ in Figure 4A-B, Supplementary Figures S3A-D, S3E-H, S3I-L, S4B-F, S4H-L, S4N-R, and Supplementary Tables 1 and 4 actually correspond to thalamus, while the samples labeled as ‘cortex’ contained a mixture of cortical and striatal tissue. Accordingly, in these figures and in the corresponding text, the label ‘striatum’ should be read as ‘thalamus,’ and the label ‘cortex’ as ‘cortex + striatum’. All behavioral, electrophysiological, and immunohistochemical data reported in the paper were obtained from whole-brain or whole-animal studies and therefore remain unaffected. The authors apologize for any inconvenience this may have caused.”
Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates
Linda Molteni, Chiara Bruzzone, Diletta Ami, Ada De Luigi, Laura Colombo, Luca Moretti, Antonino Natalello, Alessandro Palmioli, Cristina Airoldi
International Journal of Biological Macromolecules, 2025
This study provides a comprehensive structural analysis of prenylflavonoids (PFs) interaction with Aβ1–42 oligomers, revealing their potential to modulate amyloid peptide aggregation pathways. Among the tested PFs, xanthohumol (XN), isoxanthohumol (IXN) and 8-prenylnaringenin (8-PN), XN exhibited the strongest anti-amyloidogenic activity, inhibiting Aβ1–42 aggregation at substoichiometric concentrations and stabilizing the peptide in amorphous aggregates. Its higher conformational flexibility drives the distinct interaction profile and protective effect; in fact, XN forms stable complexes with Aβ1–42 oligomers, preventing their transition to β -sheet-rich fibrils. These findings highlight that XN may offer a neuroprotective strategy by redirecting Aβ1–42 aggregation toward less toxic species, in agreement with its previously described ability to reduce Aβ toxicity. Our data dissect the anti-amyloidogenic mechanism of action of XN at molecular level, providing structural insights for the rational design of a new class of Aβ inhibitors. Indeed, conventional drug discovery approaches are often ineffective against amyloid aggregates, due to their dynamic and atypical receptor structures. Instead, preventive and therapeutic strategies should focus on compounds that form stable supramolecular complexes, capable of modulating the structure and toxicity of the aggregates without relying on specific binding sites. Additionally, due also to its anti-oxidant activity, XN, naturally present in hops, shows promise as nutraceutical for Alzheimer's disease prevention. Dietary supplementation with XN could modulate early molecular events linked to neurodegeneration, providing a safe, sustainable approach to neuroprotection. • A cross-scale characterization of prenylflavonoids-Aβ1–42 interaction is provided. • Xanthohumol (XN), isoxanthohumol and 8-prenylnaringenin from hops are investigated. • XN diverts Aβ1–42 peptide aggregation toward the formation of amorphous aggregates. • The study provides structural insights for the design of Aβ aggregation modulators. • The results underscore the high potential of XN in the nutraceutical field.
The AβA2V paradigm: From molecular insights to therapeutic strategies in Alzheimer's disease and primary tauopathies
Luisa Diomede, Andrea Conz, Michele Mosconi, Tatiana Stoilova, Matteo Paloni, Matteo Salvalaglio, Alfredo Cagnotto, Laura Colombo, Marcella Catania, Giuseppe Di Fede, Fabrizio Tagliavini, Mario Salmona
Pharmacological Research, 2025
(D), which shows significant neuroprotective activity through inhibition of the assembly of amyloid β into amyloid fibrils. The therapeutic potential of this peptide emerges from its ability to reduce amyloid β-induced toxicity, with promising results from studies in human neuroblastoma cells and transgenic animal models.
Thermal effects and biological response of breast and pancreatic cancer cells undergoing gold nanorod-assisted photothermal therapy
Leonardo Bianchi, Sara Baroni, Gabriela Paroni, Martina Bruna Violatto, Giulia Yuri Moscatiello, Nicolò Panini, Luca Russo, Fabio Fiordaliso, Laura Colombo, Luisa Diomede, Paola Saccomandi, Paolo Bigini
Journal of Photochemistry and Photobiology B Biology, 2024
To increase the therapeutic efficacy of nanoparticle (NP)-assisted photothermal therapy (PTT) and allow for a transition toward the clinical setting, it is pivotal to characterize the thermal effect induced in cancer cells and correlate it with the cell biological response, namely cell viability and cell death pathways. This study quantitatively evaluated the effects of gold nanorod (GNR)-assisted near-infrared (NIR) PTT on two different cancer cell lines, the 4T1 triple-negative breast cancer cells and the Pan02 pancreatic cancer cells. The interaction between nanomaterials and biological matrices was investigated in terms of GNR internalization and effect on cell viability at different GNR concentrations. GNR-mediated PTT was executed on both cell lines, at the same treatment settings to allow a straightforward comparison, and real-time monitored through thermographic imaging. A thermal analysis based on various parameters ( i.e. , maximum absolute temperature, maximum temperature change, temperature variation profile, area under the time-temperature change curve, effective thermal enhancement (ETE), and time constants) was performed to evaluate the treatment thermal outcome. While GNR treatment and NIR laser irradiation alone did not cause cell toxicity in the selected settings, their combination induced a significant reduction of cell viability in both cell lines. At the optimal experimental condition ( i.e. , 6 μg/mL of GNRs and 4.5 W/cm 2 laser power density), GNR-assisted PTT reduced the cell viability of 4T1 and Pan02 cells by 94% and 87% and it was associated with maximum temperature changes of 25 °C and 29 °C ( i.e. , ∼1.8-fold increase compared to the laser-only condition), maximum absolute temperatures of 55 °C and 54 °C, and ETE values of 78% and 81%, for 4T1 and Pan02 cells, correspondingly. Also, the increase in the GNR concentration led to a decrease in the time constants, denoting faster heating kinetics upon irradiation. Furthermore, the thermal analysis parameters were correlated with the extent of cell death. Twelve hours after NIR exposure, GNR-assisted PTT was found to mainly trigger secondary apoptosis in both cell lines. The proposed study provides relevant insights into the relationship between temperature history and biological responses in the context of PTT. The findings contribute to the development of a universal methodology for evaluating thermal sensitivity upon NP-assisted PTT on different cell types and lay the groundwork for future translational studies. • GNR-assisted PTT significantly reduced breast and pancreatic cancer cell viability. • The thermal effects of GNR-mediated PTT were correlated with cell biological response. • Increasing GNR concentration led to faster heating kinetics upon irradiation. • 12 h post-exposure, GNR-mediated PTT was found to mainly trigger secondary apoptosis.
A cutting-edge approach based on UHPLC-MS to simultaneously investigate oxysterols and cholesterol precursors in biological samples: Validation in Huntington's disease mouse model
Alice Passoni, Monica Favagrossa, Marta Valenza, Giulia Birolini, Alessia Lanno, Caterina Mariotti, Elena Cattaneo, Mario Salmona, Laura Colombo, Renzo Bagnati
Talanta Open, 2024
Brain is most cholesterol-rich organ in the body. Since cholesterol does not cross the blood brain barrier, its metabolism is provided in situ by astrocytes and neurons, and it is crucial for maintaining sterol levels and neuronal integrity and function. Recent studies have shown that the levels of cholesterol precursors and metabolites are lower in the brains of animal models of Huntington's disease (HD) while reduced levels of its catabolite are detected in the plasma of patients. In this study, we introduce a novel analytical method designed to fulfil the complex analytical requirements associated with cholesterol metabolites detection in neurodegenerative disorders. The method allows for the simultaneous quantification of a specific set of oxysterols along with cholesterol precursors in biological samples. The proposed method uses an Ultra-High-Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS) system operating in multiple reaction monitoring (MRM). Since sterols can be found in biological matrices in either free form or esterified to various fatty acids, a three-step extraction procedure was devised, consisting of alkaline hydrolysis, liquid-liquid extraction and final concentration omitting the need for a solid-phase extraction (SPE) step. The validated method achieved a detection limit of 10 ng/mL in plasma and 1 ng/mg in brain tissue, reaching a comparable sensitivity to previously published LC-MS and GC-MS methods. All target analytes were separated on a reverse-phase column employing a segmented gradient and a temperature ramp. This strategy enabled the elution and separation of all selected metabolites within a 30-minutes timeframe. This innovative approach was employed to quantify cholesterol metabolites in both plasma and brain samples from wild-type (WT) and R6/2 mice, a mouse model of HD. The results obtained from the sample analysis highlighted a significant reduction in desmosterol levels in the R6/2 brain at 12 weeks. In conclusion, the proposed method paves the way for further development of high-sensitive and reproducible protocols to comprehensively investigate simultaneous alterations in both cholesterol biosynthesis and catabolism in HD samples.
Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease
Laura Tapella, Giulia Dematteis, Pietro La Vitola, Susanna Leva, Elisa Tonelli, Marco Raddi, Marta Delconti, Letizia Dacomo, Alberto La Macchia, Elisa Murari, Maria Talmon, Justyna Malecka, Gabriela Chrostek, Mariagrazia Grilli, Laura Colombo, Mario Salmona, Gianluigi Forloni, Armando A. Genazzani, Claudia Balducci, Dmitry Lim
GLIA, 2024
Alzheimer's disease (AD) represents an urgent yet unmet challenge for modern society, calling for exploration of innovative targets and therapeutic approaches. Astrocytes, main homeostatic cells in the CNS, represent promising cell‐target. Our aim was to investigate if deletion of the regulatory CaNB1 subunit of calcineurin in astrocytes could mitigate AD‐related memory deficits, neuropathology, and neuroinflammation. We have generated two, acute and chronic, AD mouse models with astrocytic CaNB1 ablation (ACN‐KO). In the former, we evaluated the ability of β‐amyloid oligomers (AβOs) to impair memory and activate glial cells once injected in the cerebral ventricle of conditional ACN‐KO mice. Next, we generated a tamoxifen‐inducible astrocyte‐specific CaNB1 knock‐out in 3xTg‐AD mice (indACNKO‐AD). CaNB1 was deleted, by tamoxifen injection, in 11.7‐month‐old 3xTg‐AD mice for 4.4 months. Spatial memory was evaluated using the Barnes maze; β‐amyloid plaques burden, neurofibrillary tangle deposition, reactive gliosis, and neuroinflammation were also assessed. The acute model showed that ICV injected AβOs in 2‐month‐old wild type mice impaired recognition memory and fostered a pro‐inflammatory microglia phenotype, whereas in ACN‐KO mice, AβOs were inactive. In indACNKO‐AD mice, 4.4 months after CaNB1 depletion, we found preservation of spatial memory and cognitive flexibility, abolishment of amyloidosis, and reduction of neurofibrillary tangles, gliosis, and neuroinflammation. Our results suggest that ACN is crucial for the development of cognitive impairment, AD neuropathology, and neuroinflammation. Astrocyte‐specific CaNB1 deletion is beneficial for both the abolishment of AβO‐mediated detrimental effects and treatment of ongoing AD‐related pathology, hence representing an intriguing target for AD therapy.
Cell-Free and In Vivo Characterization of the Inhibitory Activity of Lavado Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3
Barbara Sciandrone, Alessandro Palmioli, Carlotta Ciaramelli, Roberta Pensotti, Laura Colombo, Maria Elena Regonesi, Cristina Airoldi
ACS Chemical Neuroscience, 2024
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by ataxia and other neurological manifestations, with a poor prognosis and a lack of effective therapies. The amyloid aggregation of the ataxin-3 protein is a hallmark of SCA3 and one of the main biochemical events prompting its onset, making it a prominent target for the development of preventive and therapeutic interventions. Here, we tested the efficacy of an aqueous Lavado cocoa extract and its polyphenolic components against ataxin-3 aggregation and neurotoxicity. The combination of biochemical assays and atomic force microscopy morphological analysis provided clear evidence of cocoa flavanols' ability to hinder ATX3 amyloid aggregation through direct physical interaction, as assessed by NMR spectroscopy. The chemical identity of the flavanols was investigated by ultraperformance liquid chromatography-high-resolution mass spectrometry. The use of the preclinical model Caenorhabditis elegans allowed us to demonstrate cocoa flavanols' ability to ameliorate ataxic phenotypes in vivo. To the best of our knowledge, Lavado cocoa is the first natural source whose extract is able to directly interfere with ATX3 aggregation, leading to the formation of off-pathway species.
Characterization of the Laser-induced Thermal Outcome of Gold Nanorods-mediated Photothermal Therapy in Breast Cancer Cells
Leonardo Bianchi, Sara Baroni, Gabriela Paroni, Martina Bruna Violatto, Giulia Yuri Moscatiello, Luca Russo, Fabio Fiordaliso, Laura Colombo, Luisa Diomede, Paolo Bigini, Paola Saccomandi
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, 2024
Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease
Giulia Birolini, Marta Valenza, Ilaria Ottonelli, Francesca Talpo, Lucia Minoli, Andrea Cappelleri, Mauro Bombaci, Claudio Caccia, Caterina Canevari, Arianna Trucco, Valerio Leoni, Alice Passoni, Monica Favagrossa, Maria Rosaria Nucera, Laura Colombo, Saverio Paltrinieri, Renzo Bagnati, Jason Thomas Duskey, Riccardo Caraffi, Maria Angela Vandelli, Franco Taroni, Mario Salmona, Eugenio Scanziani, Gerardo Biella, Barbara Ruozi, Giovanni Tosi, Elena Cattaneo
Pharmacological Research, 2023
Aβ1-6A2V(D) peptide, effective on Aβ aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury
Luisa Diomede, Elisa R. Zanier, Federico Moro, Gloria Vegliante, Laura Colombo, Luca Russo, Alfredo Cagnotto, Carmina Natale, Federica Marta Xodo, Ada De Luigi, Michele Mosconi, Marten Beeg, Marcella Catania, Giacomina Rossi, Fabrizio Tagliavini, Giuseppe Di Fede, Mario Salmona
Molecular Psychiatry, 2023
Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse
Margarita C. Dinamarca, Laura Colombo, Urszula Brykczynska, Amandine Grimm, Isabelle Fruh, Imtiaz Hossain, Daniela Gabriel, Anne Eckert, Matthias Müller, Eline Pecho-Vrieseling
Frontiers in Molecular Neuroscience, 2023
A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease
Marcella Catania, Laura Colombo, Stefano Sorrentino, Alfredo Cagnotto, Jacopo Lucchetti, Maria Chiara Barbagallo, Ilaria Vannetiello, Elena Rita Vecchi, Monica Favagrossa, Massimo Costanza, Giorgio Giaccone, Mario Salmona, Fabrizio Tagliavini, Giuseppe Di Fede
Molecular Psychiatry, 2022
Dysmyelination and glycolipid interference caused by phenylalanine in phenylketonuria
Valeria Rondelli, Alexandros Koutsioubas, Emanuela Di Cola, Giovanna Fragneto, I. Grillo, Elena Del Favero, Laura Colombo, Laura Cantù, Paola Brocca, Mario Salmona
International Journal of Biological Macromolecules, 2022
Alzheimer's Disease Prevention through Natural Compounds: Cell-Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity
Alessandro Palmioli, Valeria Mazzoni, Ada De Luigi, Chiara Bruzzone, Gessica Sala, Laura Colombo, Chiara Bazzini, Chiara Paola Zoia, Mariagiovanna Inserra, Mario Salmona, Ivano De Noni, Carlo Ferrarese, Luisa Diomede, Cristina Airoldi
ACS Chemical Neuroscience, 2022
Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis
Joseph Windheim, Laura Colombo, Nora C. Battajni, Luca Russo, Alfredo Cagnotto, Luisa Diomede, Paolo Bigini, Elena Vismara, Ferdinando Fiumara, Silvia Gabbrielli, Alfonso Gautieri, Gemma Mazzuoli-Weber, Mario Salmona, Luca Colnaghi
International Journal of Molecular Sciences, 2022
Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC‐derived neurons
Margarita C. Dinamarca, Laura Colombo, Natalia E. Tousiaki, Matthias Müller, Eline Pecho-Vrieseling
Frontiers in Molecular Biosciences, 2022
NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity
Carlotta Ciaramelli, Alessandro Palmioli, Irene Angotti, Laura Colombo, Ada De Luigi, Gessica Sala, Mario Salmona, Cristina Airoldi
Frontiers in Chemistry, 2022
Biochemical and biophysical features of disease-associated tau mutants V363A and V363I
Ada De Luigi, Laura Colombo, Luca Russo, Caterina Ricci, Antonio Bastone, Sara Cimini, Fabrizio Tagliavini, Giacomina Rossi, Laura Cantù, Elena Del Favero, Mario Salmona
Biochimica Et Biophysica Acta Proteins and Proteomics, 2022
Microbiological-chemical sourced chondroitin sulfates protect neuroblastoma SH-SY5Y cells against oxidative stress and are suitable for hydrogel-based controlled release
Emiliano Bedini, Alfonso Iadonisi, Chiara Schiraldi, Laura Colombo, Diego Albani, Paola Petrini, Carmen Giordano, Marta Tunesi
Antioxidants, 2021
Sleep inhibition induced by amyloid-β oligomers is mediated by the cellular prion protein
F. Del Gallo, S. Bianchi, I. Bertani, Massimo Messa, L. Colombo, C. Balducci, M. Salmona, L. Imeri, R. Chiesa
Journal of Sleep Research, 2021
C. elegans detects toxicity of traumatic brain injury generated tau
Elisa R. Zanier, Maria Monica Barzago, Gloria Vegliante, Margherita Romeo, Elena Restelli, Ilaria Bertani, Carmina Natale, Luca Colnaghi, Laura Colombo, Luca Russo, Edoardo Micotti, Luana Fioriti, Roberto Chiesa, Luisa Diomede
Neurobiology of Disease, 2021
NMR-based Lavado cocoa chemical characterization and comparison with fermented cocoa varieties: Insights on cocoa's anti-amyloidogenic activity
Carlotta Ciaramelli, Alessandro Palmioli, Ada De Luigi, Laura Colombo, Gessica Sala, Mario Salmona, Cristina Airoldi
Food Chemistry, 2021
Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease
Giulia Birolini, Marta Valenza, Ilaria Ottonelli, Alice Passoni, Monica Favagrossa, Jason T. Duskey, Mauro Bombaci, Maria Angela Vandelli, Laura Colombo, Renzo Bagnati, Claudio Caccia, Valerio Leoni, Franco Taroni, Flavio Forni, Barbara Ruozi, Mario Salmona, Giovanni Tosi, Elena Cattaneo
Journal of Controlled Release, 2021
Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models
P. La Vitola, C. Balducci, M. Baroni, L. Artioli, G. Santamaria, M. Castiglioni, M. Cerovic, L. Colombo, L. Caldinelli, L. Pollegioni, G. Forloni
Neuropathology and Applied Neurobiology, 2021
Nonphosphorylated tau slows down Aβ1-42 aggregation, binds to Aβ1-42 oligomers, and reduces Aβ1-42 toxicity
Marten Beeg, Elisabetta Battocchio, Ada De Luigi, Laura Colombo, Carmina Natale, Alfredo Cagnotto, Alessandro Corbelli, Fabio Fiordaliso, Luisa Diomede, Mario Salmona, Marco Gobbi
Journal of Biological Chemistry, 2021
Aβ beyond the ad pathology: Exploring the structural response of membranes exposed to nascent aβ peptide
Valeria Rondelli, Mario Salmona, Laura Colombo, Giovanna Fragneto, Giulia C. Fadda, Laura Cantu’, Elena Del Favero
International Journal of Molecular Sciences, 2020
Cellulose nanocrystals: A multimodal tool to enhance the targeted drug delivery against bone disorders
Luca Zoia, Annalisa Morelli, Laura Talamini, Martina B Violatto, Arianna B Lovati, Silvia Lopa, Camilla Recordati, Chiara Toffanin, Anika Salanti, Luca Russo, Laura Colombo, Matteo Moretti, Mario Salmona, Barbara La Ferla, Paolo Bigini
Nanomedicine, 2020
Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1–42-mediated toxicity
Debasmita Tripathy, Alice Migazzi, Federica Costa, Alessandro Roncador, Pamela Gatto, Federica Fusco, Lucia Boeri, Diego Albani, J. Leon Juárez-Hernández, Carlo Musio, Laura Colombo, Mario Salmona, M.M. Micha Wilhelmus, Benjamin Drukarch, Maria Pennuto, Manuela Basso
Neurobiology of Disease, 2020
Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease
Roberta Ruotolo, Ilaria Minato, Pietro La Vitola, Luisa Artioli, Claudio Curti, Valentina Franceschi, Nicoletta Brindani, Davide Amidani, Laura Colombo, Mario Salmona, Gianluigi Forloni, Gaetano Donofrio, Claudia Balducci, Daniele Del Rio, Simone Ottonello
Molecular Nutrition and Food Research, 2020
Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington's Disease
Alice Passoni, Monica Favagrossa, Laura Colombo, Renzo Bagnati, Marco Gobbi, Luisa Diomede, Giulia Birolini, Eleonora Di Paolo, Marta Valenza, Elena Cattaneo, Mario Salmona
ACS Chemical Neuroscience, 2020
Hydrogel-based delivery of Tat-fused protein Hsp70 protects dopaminergic cells in vitro and in a mouse model of Parkinson’s disease
Marta Tunesi, Ilaria Raimondi, Teresa Russo, Laura Colombo, Edoardo Micotti, Edoardo Brandi, Pamela Cappelletti, Alberto Cigada, Alessandro Negro, Luigi Ambrosio, Gianluigi Forloni, Loredano Pollegioni, Antonio Gloria, Carmen Giordano, Diego Albani
Npg Asia Materials, 2019
The anti-amyloidogenic action of doxycycline: A molecular dynamics study on the interaction with Aβ42
Alfonso Gautieri, Marten Beeg, Marco Gobbi, Federica Rigoldi, Laura Colombo, Mario Salmona
International Journal of Molecular Sciences, 2019
bioNMR-based identification of natural anti-Aβ compounds in Peucedanum ostruthium
Alessandro Palmioli, Sara Bertuzzi, Ada De Luigi, Laura Colombo, Barbara La Ferla, Mario Salmona, Ivano De Noni, Cristina Airoldi
Bioorganic Chemistry, 2019
Cellular prion protein neither binds to alpha-synuclein oligomers nor mediates their detrimental effects
Pietro La Vitola, Marten Beeg, Claudia Balducci, Giulia Santamaria, Elena Restelli, Laura Colombo, Laura Caldinelli, Loredano Pollegioni, Marco Gobbi, Roberto Chiesa, Gianluigi Forloni
Brain, 2019
p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation
Donghui Liu, Yasmin Zeinolabediny, Francesca Caccuri, Glenn Ferris, Wen-Hui Fang, Ria Weston, Jerzy Krupinski, Laura Colombo, Mario Salmona, Ruben Corpas, Sara Sarroca, Coral Sanfeliu, Arnaldo Caruso, Baoqiang Guo, Xianwei Zeng, Mark Slevin
Laboratory Investigation, 2019
Molecular subtypes of Alzheimer's disease
Giuseppe Di Fede, Marcella Catania, Emanuela Maderna, Roberta Ghidoni, Luisa Benussi, Elisa Tonoli, Giorgio Giaccone, Fabio Moda, Anna Paterlini, Ilaria Campagnani, Stefano Sorrentino, Laura Colombo, Adriana Kubis, Edoardo Bistaffa, Bernardino Ghetti, Fabrizio Tagliavini
Scientific Reports, 2018
In Situ Tissue Labeling of Cerebral Amyloid Using HIV-Related Tat Peptide
E. Maderna, L. Colombo, A. Cagnotto, G. Di Fede, A. Indaco, F. Tagliavini, M. Salmona, G. Giaccone
Molecular Neurobiology, 2018
NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts
Carlotta Ciaramelli, Alessandro Palmioli, Ada De Luigi, Laura Colombo, Gessica Sala, Chiara Riva, Chiara Paola Zoia, Mario Salmona, Cristina Airoldi
Food Chemistry, 2018
Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2
Pietro La Vitola, Claudia Balducci, Milica Cerovic, Giulia Santamaria, Edoardo Brandi, Federica Grandi, Laura Caldinelli, Laura Colombo, Maria Grazia Morgese, Luigia Trabace, Loredano Pollegioni, Diego Albani, Gianluigi Forloni
Brain Behavior and Immunity, 2018
The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study
Laura Cantu’, Laura Colombo, Tatiana Stoilova, Bruno Demé, Hideyo Inouye, Rachel Booth, Valeria Rondelli, Giuseppe Di Fede, Fabrizio Tagliavini, Elena Del Favero, Daniel A. Kirschner, Mario Salmona
Scientific Reports, 2017
HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders
Yasmin Zeinolabediny, Francesca Caccuri, Laura Colombo, Federica Morelli, Margherita Romeo, Alessandro Rossi, Silvia Schiarea, Carlotta Ciaramelli, Cristina Airoldi, Ria Weston, Liu Donghui, Jerzy Krupinski, Rubén Corpas, Elisa García-Lara, Sara Sarroca, Coral Sanfeliu, Mark Slevin, Arnaldo Caruso, Mario Salmona, Luisa Diomede
Scientific Reports, 2017
Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction
Laura Colombo, Alessio Gamba, Laura Cantù, Mario Salmona, Fabrizio Tagliavini, Valeria Rondelli, Elena Del Favero, Paola Brocca
Biophysical Chemistry, 2017
Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer's disease
Claudia Balducci, Angelisa Frasca, Margherita Zotti, Pietro La Vitola, Emanuela Mhillaj, Emanuele Grigoli, Martina Iacobellis, Federica Grandi, Massimo Messa, Laura Colombo, Monica Molteni, Luigia Trabace, Carlo Rossetti, Mario Salmona, Gianluigi Forloni
Brain Behavior and Immunity, 2017
Flavonoids and Their Glycosides as Anti-amyloidogenic Compounds: Aβ1–42 Interaction Studies to Gain New Insights into Their Potential for Alzheimer's Disease Prevention and Therapy
Cinzia Guzzi, Laura Colombo, Ada De Luigi, Mario Salmona, Francesco Nicotra, Cristina Airoldi
Chemistry an Asian Journal, 2017
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein
Giusi Manassero, Michela Guglielmotto, Raluca Zamfir, Roberta Borghi, Laura Colombo, Mario Salmona, George Perry, Patrizio Odetti, Ottavio Arancio, Elena Tamagno, Massimo Tabaton
Aging Cell, 2016
The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt
Sara Cimini, Alessandra Sclip, Simona Mancini, Laura Colombo, Massimo Messa, Alfredo Cagnotto, Giuseppe Di Fede, Fabrizio Tagliavini, Mario Salmona, Tiziana Borsello
Neurobiology of Disease, 2016
Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer
Leopoldo Sitia, Raffaele Ferrari, Martina B. Violatto, Laura Talamini, Luca Dragoni, Claudio Colombo, Laura Colombo, Monica Lupi, Paolo Ubezio, Maurizio D’Incalci, Massimo Morbidelli, Mario Salmona, Davide Moscatelli, Paolo Bigini
Biomacromolecules, 2016
Synthesis and Preliminary Biological Evaluation of Fluorescent Glycofused Tricyclic Derivatives of Amyloid β-Peptide Ligands
Giuseppe D'Orazio, Laura Colombo, Mario Salmona, Barbara La Ferla
European Journal of Organic Chemistry, 2016
Amyloidβ Peptides in interaction with raft-mime model membranes: A neutron reflectivity insight
Valeria Rondelli, Paola Brocca, Simona Motta, Massimo Messa, Laura Colombo, Mario Salmona, Giovanna Fragneto, Laura Cantù, Elena Del Favero
Scientific Reports, 2016
Tackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β
Giuseppe Di Fede, Marcella Catania, Emanuela Maderna, Michela Morbin, Fabio Moda, Laura Colombo, Alessandro Rossi, Alfredo Cagnotto, Tommaso Virgilio, Luisa Palamara, Margherita Ruggerone, Giorgio Giaccone, Ilaria Campagnani, Massimo Costanza, Rosetta Pedotti, Matteo Salvalaglio, Mario Salmona, Fabrizio Tagliavini
Scientific Reports, 2016
Structural Modifications of cis-Glycofused Benzopyran Compounds and Their Influence on the Binding to Amyloid-β Peptide
Cristina Airoldi, Giuseppe D'Orazio, Barbara Richichi, Cinzia Guzzi, Veronica Baldoneschi, Laura Colombo, Mario Salmona, Cristina Nativi, Francesco Nicotra, Barbara La Ferla
Chemistry an Asian Journal, 2016
Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria
Ada De Luigi, Alessandro Mariani, Massimiliano De Paola, Andrea Re Depaolini, Laura Colombo, Luca Russo, Valeria Rondelli, Paola Brocca, Lihi Adler-Abramovich, Ehud Gazit, Elena Del Favero, Laura Cantù, Mario Salmona
Scientific Reports, 2015
Organ distribution and bone tropism of cellulose nanocrystals in living mice
Laura Colombo, Luca Zoia, Martina B. Violatto, Sara Previdi, Laura Talamini, Leopoldo Sitia, Francesco Nicotra, Marco Orlandi, Mario Salmona, Camilla Recordati, Paolo Bigini, Barbara La Ferla
Biomacromolecules, 2015
Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in alzheimer’s disease mouse models
Claudia Balducci, Simona Mancini, Stefania Minniti, Pietro La Vitola, Margherita Zotti, Giulio Sancini, Mario Mauri, Alfredo Cagnotto, Laura Colombo, Fabio Fiordaliso, Emanuele Grigoli, Mario Salmona, Anniina Snellman, Merja Haaparanta-Solin, Gianluigi Forloni, Massimo Masserini, Francesca Re
Journal of Neuroscience, 2014
Natural compounds against neurodegenerative diseases: Molecular characterization of the interaction of catechins from green tea with Aβ1-42, PrP106-126, and ataxin-3 oligomers
Erika Sironi, Laura Colombo, Angela Lompo, Massimo Messa, Marcella Bonanomi, Maria Elena Regonesi, Mario Salmona, Cristina Airoldi
Chemistry A European Journal, 2014
Monomeric Aβ1-42 and RAGE: Key players in neuronal differentiation
Sabrina Piras, Anna L. Furfaro, Alessandra Piccini, Mario Passalacqua, Roberta Borghi, Enrico Carminati, Alessia Parodi, Laura Colombo, Mario Salmona, Maria A. Pronzato, Umberto M. Marinari, Massimo Tabaton, Mariapaola Nitti
Neurobiology of Aging, 2014
Role of lipid rafts and GM1 in the segregation and processing of prion protein
Laura Botto, Diana Cunati, Silvia Coco, Silvia Sesana, Alessandra Bulbarelli, Emiliano Biasini, Laura Colombo, Alessandro Negro, Roberto Chiesa, Massimo Masserini, Paola Palestini
Plos One, 2014
Cis-glyco-fused benzopyran derivatives as hit compounds for the development of therapeutic and diagnostic tools against neurodegenerative diseases
Silvia Merlo, Erika Sironi, Laura Colombo, Francisco Cardona, Alessandra M. Martorana, Mario Salmona, Barbara La Ferla, Cristina Airoldi
Chempluschem, 2014
The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly
Massimo Messa, Laura Colombo, Elena del Favero, Laura Cantù, Tatiana Stoilova, Alfredo Cagnotto, Alessandro Rossi, Michela Morbin, Giuseppe Di Fede, Fabrizio Tagliavini, Mario Salmona
Journal of Biological Chemistry, 2014
An integrated approach for the systematic evaluation of polymeric nanoparticles in healthy and diseased organisms
Leopoldo Sitia, Katia Paolella, Michela Romano, Martina Bruna Violatto, Raffaele Ferrari, Stefano Fumagalli, Laura Colombo, Ezia Bello, Maria Grazia De Simoni, Maurizio D’Incalci, Massimo Morbidelli, Eugenio Erba, Mario Salmona, Davide Moscatelli, Paolo Bigini
Journal of Nanoparticle Research, 2014
Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease
Cristina Airoldi, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Ilaria Cambianica, Francesca Ornaghi, Giulio Sancini, Francesco Nicotra, Barbara La Ferla
Pure and Applied Chemistry, 2013
A new face for old antibiotics: Tetracyclines in treatment of amyloidoses
Tatiana Stoilova, Laura Colombo, Gianluigi Forloni, Fabrizio Tagliavini, Mario Salmona
Journal of Medicinal Chemistry, 2013
Soluble Aβ oligomer-induced synaptopathy: C-Jun N-terminal kinase's role
Alessandra Sclip, Andrea Arnaboldi, Isabella Colombo, Pietro Veglianese, Laura Colombo, Massimo Messa, Simona Mancini, Sara Cimini, Federica Morelli, Xanthi Antoniou, Egbert Welker, Mario Salmona, Tiziana Borsello
Journal of Molecular Cell Biology, 2013
Biocompatible fluorescent nanoparticles for in vivo stem cell tracking
Lidia Cova, Paolo Bigini, Valentina Diana, Leopoldo Sitia, Raffaele Ferrari, Ruggiero Maria Pesce, Rushd Khalaf, Patrizia Bossolasco, Paolo Ubezio, Monica Lupi, Massimo Tortarolo, Laura Colombo, Daniela Giardino, Vincenzo Silani, Massimo Morbidelli, Mario Salmona, Davide Moscatelli
Nanotechnology, 2013
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
Brian R. Fluharty, Emiliano Biasini, Matteo Stravalaci, Alessandra Sclip, Luisa Diomede, Claudia Balducci, Pietro La Vitola, Massimo Messa, Laura Colombo, Gianluigi Forloni, Tiziana Borsello, Marco Gobbi, David A. Harris
Journal of Biological Chemistry, 2013
Good gene, bad gene: New APP variant may be both
Giuseppe Di Fede, Marcella Catania, Michela Morbin, Giorgio Giaccone, Maria Luisa Moro, Roberta Ghidoni, Laura Colombo, Massimo Messa, Alfredo Cagnotto, Margherita Romeo, Matteo Stravalaci, Luisa Diomede, Marco Gobbi, Mario Salmona, Fabrizio Tagliavini
Progress in Neurobiology, 2012
β-Amyloid 1-42 induces physiological transcriptional regulation of BACE1
Alessandra Piccini, Roberta Borghi, Michela Guglielmotto, Elena Tamagno, Gabriella Cirmena, Anna Garuti, Valeria Pollero, Sergio Cammarata, Michele Fornaro, Massimo Messa, Laura Colombo, Mario Salmona, George Perry, Massimo Tabaton
Journal of Neurochemistry, 2012
Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans
Matteo Stravalaci, Antonio Bastone, Marten Beeg, Alfredo Cagnotto, Laura Colombo, Giuseppe Di Fede, Fabrizio Tagliavini, Laura Cantù, Elena Del Favero, Michele Mazzanti, Roberto Chiesa, Mario Salmona, Luisa Diomede, Marco Gobbi
Journal of Biological Chemistry, 2012
Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease
Paolo Bigini, Valentina Diana, Sara Barbera, Elena Fumagalli, Edoardo Micotti, Leopoldo Sitia, Alessandra Paladini, Cinzia Bisighini, Laura De Grada, Laura Coloca, Laura Colombo, Pina Manca, Patrizia Bossolasco, Francesca Malvestiti, Fabio Fiordaliso, Gianluigi Forloni, Massimo Morbidelli, Mario Salmona, Daniela Giardino, Tiziana Mennini, Davide Moscatelli, Vincenzo Silani, Lidia Cova
Plos One, 2012
Cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands
Cristina Airoldi, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Artur Silva, Francesco Nicotra, Barbara La Ferla
Chemical Communications, 2011
The molecular assembly of amyloid Aβ controls its neurotoxicity and binding to cellular proteins
Claudia Manzoni, Laura Colombo, Paolo Bigini, Valentina Diana, Alfredo Cagnotto, Massimo Messa, Monica Lupi, Valentina Bonetto, Mauro Pignataro, Cristina Airoldi, Erika Sironi, Alun Williams, Mario Salmona
Plos One, 2011
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils
Sandra Gemma, Laura Colombo, Gianluigi Forloni, Luisa Savini, Claudia Fracasso, Silvio Caccia, Mario Salmona, Margherita Brindisi, Bhupendra P. Joshi, Pierangela Tripaldi, Gianluca Giorgi, Orazio Taglialatela-Scafati, Ettore Novellino, Isabella Fiorini, Giuseppe Campiani, Stefania Butini
Organic and Biomolecular Chemistry, 2011
Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction
Cristina Airoldi, Laura Colombo, Claudia Manzoni, Erika Sironi, Antonino Natalello, Silvia Maria Doglia, Gianluigi Forloni, Fabrizio Tagliavini, Elena Del Favero, Laura Cantù, Francesco Nicotra, Mario Salmona
Organic and Biomolecular Chemistry, 2011
Curcumin derivatives as new ligands of Aβ peptides
Cristina Airoldi, Cristiano Zona, Erika Sironi, Laura Colombo, Massimo Messa, Dario Aurilia, Maria Gregori, Massimo Masserini, Mario Salmona, Francesco Nicotra, Barbara La Ferla
Journal of Biotechnology, 2011
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein
Claudia Balducci, Marten Beeg, Matteo Stravalaci, Antonio Bastone, Alessandra Sclip, Emiliano Biasini, Laura Tapella, Laura Colombo, Claudia Manzoni, Tiziana Borsello, Roberto Chiesa, Marco Gobbi, Mario Salmona, Gianluigi Forloni
Proceedings of the National Academy of Sciences of the United States of America, 2010
Overcoming synthetic Aβ peptide aging: A new approach to an age-old problem
Claudia Manzoni, Laura Colombo, Massimo Messa, Alfredo Cagnotto, Laura Cantù, Elena Del Favero, Mario Salmona
Amyloid, 2009
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
Diego Albani, Letizia Polito, Sara Batelli, Stefania De Mauro, Claudia Fracasso, Giuliana Martelli, Laura Colombo, Claudia Manzoni, Mario Salmona, Silvio Caccia, Alessandro Negro, Gianluigi Forloni
Journal of Neurochemistry, 2009
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis
Giuseppe Di Fede, Marcella Catania, Michela Morbin, Giacomina Rossi, Silvia Suardi, Giulia Mazzoleni, Marco Merlin, Anna Rita Giovagnoli, Sara Prioni, Alessandra Erbetta, Chiara Falcone, Marco Gobbi, Laura Colombo, Antonio Bastone, Marten Beeg, Claudia Manzoni, Bruna Francescucci, Alberto Spagnoli, Laura Cantù, Elena Del Favero, Efrat Levy, Mario Salmona, Fabrizio Tagliavini
Science, 2009
ST1859 reduces prion infectivity and increase survival in experimental scrapie.
Laura Colombo, Paola Piovesan, Orlando Ghirardi, Mario Salmona, Gianluigi Forloni
Archives of Virology, 2009
Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process
M. Pera, A. Martínez-Otero, L. Colombo, M. Salmona, D. Ruiz-Molina, A. Badia, M.V. Clos
Molecular and Cellular Neuroscience, 2009
Conformational Plasticity of the Gerstmann-Sträussler-Scheinker Disease Peptide as Indicated by Its Multiple Aggregation Pathways
Antonino Natalello, Valery V. Prokorov, Fabrizio Tagliavini, Michela Morbin, Gianluigi Forloni, Marten Beeg, Claudia Manzoni, Laura Colombo, Marco Gobbi, Mario Salmona, Silvia Maria Doglia
Journal of Molecular Biology, 2008
The anti-fibrillogenic activity of tetracyclines on PrP 106-126: A 3D-QSAR study
Ugo Cosentino, Demetrio Pitea, Giorgio Moro, Gloria A. A. Saracino, Pietro Caria, Rosaria M. Varì, Laura Colombo, Gianluigi Forloni, Fabrizio Tagliavini, Mario Salmona
Journal of Molecular Modeling, 2008
Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Aβ1-42
Clive Bate, Victoria Marshall, Laura Colombo, Luisa Diomede, Mario Salmona, Alun Williams
Neuropharmacology, 2008
The efficacy of tetracyclines in peripheral and intracerebral prion infection
Ada De Luigi, Laura Colombo, Luisa Diomede, Raffaella Capobianco, Michela Mangieri, Claudia Miccolo, Lucia Limido, Gianluigi Forloni, Fabrizio Tagliavini, Mario Salmona
Plos One, 2008
Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein
Luana Fioriti, Nadia Angeretti, Laura Colombo, Ada De Luigi, Alessio Colombo, Claudia Manzoni, Michela Morbin, Fabrizio Tagliavini, Mario Salmona, Roberto Chiesa, Gianluigi Forloni
Journal of Neuroscience, 2007
Acetylcholinesterase triggers the aggregation of PrP 106-126
M. Pera, S. Román, M. Ratia, P. Camps, D. Muñoz-Torrero, L. Colombo, C. Manzoni, M. Salmona, A. Badia, M.V. Clos
Biochemical and Biophysical Research Communications, 2006
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
Marco Gobbi, Laura Colombo, Michela Morbin, Giulia Mazzoleni, Elena Accardo, Marco Vanoni, Elena Del Favero, Laura Cantù, Daniel A. Kirschner, Claudia Manzoni, Marten Beeg, Paolo Ceci, Paolo Ubezio, Gianluigi Forloni, Fabrizio Tagliavini, Mario Salmona
Journal of Biological Chemistry, 2006
Role of plasminogen in propagation of scrapie
Mario Salmona, Raffaella Capobianco, Laura Colombo, Ada De Luigi, Giacomina Rossi, Michela Mangieri, Giorgio Giaccone, Elena Quaglio, Roberto Chiesa, Maria Benedetta Donati, Fabrizio Tagliavini, Gianluigi Forloni
Journal of Virology, 2005
The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species
Luana Fioriti, Elena Quaglio, Tania Massignan, Laura Colombo, Richard S. Stewart, Mario Salmona, David A. Harris, Gianluigi Forloni, Roberto Chiesa
Molecular and Cellular Neuroscience, 2005
Regulation and biochemistry of mouse molybdo-flavoenzymes: The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase
Ruth Vila, Mami Kurosaki, Maria Monica Barzago, Metodej Kolek, Antonio Bastone, Laura Colombo, Mario Salmona, Mineko Terao, Enrico Garattini
Journal of Biological Chemistry, 2004
Structural Properties of Gerstmann-Sträussler-Scheinker Disease Amyloid Protein
Mario Salmona, Michela Morbin, Tania Massignan, Laura Colombo, Giulia Mazzoleni, Raffaella Capobianco, Luisa Diomede, Florian Thaler, Luca Mollica, Giovanna Musco, Joseph J. Kourie, Orso Bugiani, Deepak Sharma, Hideyo Inouye, Daniel A. Kirschner, Gianluigi Forloni, Fabrizio Tagliavini
Journal of Biological Chemistry, 2003
Evaluation of quinacrine treatment for prion diseases
A. Barret, F. Tagliavini, G. Forloni, C. Bate, M. Salmona, L. Colombo, A. De Luigi, L. Limido, S. Suardi, G. Rossi, F. Auvré, K. T. Adjou, N. Salès, A. Williams, C. Lasmézas, J. P. Deslys
Journal of Virology, 2003
In vitro Evaluation of the Anti-prionic Activity of Newly Synthesized Congo Red Derivatives
Giorgio Poli, Wilma Ponti, Gabriella Carcassola, Fabrizio Ceciliani, Laura Colombo, Paola Dall’Ara, Marco Gervasoni, Maria Giannino, Piera Martino, Claudia Poller, Stefania Villa, Mario Salmona
Arzneimittel Forschung Drug Research, 2003
Synthetic miniprion PrP106
Valentina Bonetto, Tania Massignan, Roberto Chiesa, Michela Morbin, Giulia Mazzoleni, Luisa Diomede, Nadia Angeretti, Laura Colombo, Gianluigi Forloni, Fabrizio Tagliavini, Mario Salmona
Journal of Biological Chemistry, 2002
Tetracyclines affect prion infectivity
Gianluigi Forloni, Selina Iussich, Tazeen Awan, Laura Colombo, Nadia Angeretti, Laura Girola, Ilaria Bertani, Giorgio Poli, Maria Caramelli, Maria Grazia Bruzzone, Laura Farina, Lucia Limido, Giacomina Rossi, Giorgio Giaccone, James W. Ironside, Orso Bugiani, Mario Salmona, Fabrizio Tagliavini
Proceedings of the National Academy of Sciences of the United States of America, 2002
Alteration of elastin, collagen and their cross-links in abdominal aortic aneurysms
M. Carmo, L. Colombo, A. Bruno, F.R.M. Corsi, L. Roncoroni, M.S. Cuttin, F. Radice, E. Mussini, P.G. Settembrini
European Journal of Vascular and Endovascular Surgery, 2002
Anti-amyloidogenic activity of tetracyclines: Studies in vitro
Gianluigi Forloni, Laura Colombo, Laura Girola, Fabrizio Tagliavini, Mario Salmona
FEBS Letters, 2001
Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro
Fabrizio Tagliavini, Gianluigi Forloni, Laura Colombo, Giacomina Rossi, Laura Girola, Barbara Canciani, Nadia Angeretti, Lidia Giampaolo, Elisa Peressini, Tazeen Awan, Luca De Gioia, Enzio Ragg, Orso Bugiani, Mario Salmona
Journal of Molecular Biology, 2000
Assay for 5-hydroxylysine and L-lysine in human and rat urine and in bone by gas chromatography
D Euli, L Colombo, A Bruno, E Mussini
Journal of Chromatography B Biomedical Sciences and Applications, 1999
Biochemical markers of upper esophageal sphincter compliance in patients with Zenker's diverticulum
Marco Venturi, Luigi Bonavina, Laura Colombo, Laura Antoniazzi, Alessandra Bruno, Emilio Mussini, Alberto Peracchia
Journal of Surgical Research, 1997
Biochemical assay of collagen and elastin in the normal and varicose vein wall
Marco Venturi, Luigi Bonavina, Federico Annoni, Laura Colombo, Caterina Butera, Alberto Peracchia, Emilio Mussini
Journal of Surgical Research, 1996
Determination of pyridinium crosslinks in plasma and serum by high-performance liquid chromatography
Gianalfredo Abbiati, Massimo Rigoldi, Serena Frignani, Laura Colombo, Emilio Mussini
Journal of Chromatography B Biomedical Sciences and Applications, 1994
Role of bile acids and metabolic activity of colonic bacteria in increased risk of colon cancer after cholecystectomy
Ettore Zuccato, Marco Venturi, Giuseppe Di Leo, Laura Colombo, Cristina Bertolo, Santo Bressani Doldi, Emilio Mussini
Digestive Diseases and Sciences, 1993
Indomethacin-induced enteropathy: Effect of the drug regimen on intestinal permeability in rats
E. Zuccato, C. Bertolo, L. Colombo, E. Mussini
Agents and Actions, 1992
Determination of ambroxol in biological material by gas chromatography with electron-capture detection
L. Colombo, F. Marcucci, M.G. Marini, P. Pierfederici, E. Mussini
Journal of Chromatography B Biomedical Sciences and Applications, 1990
Effect of swimming on protein degradation: 3-methylhistidine and creatinine excretion
E. Mussini, L. Colombo, G. De Ponte, M. Calzi, F. Marcucci
Biochemical Medicine, 1985
Gas chromatographic quantitative determination of 1- and 3-methylhistidine in urine and muscles: comparison with glass capillary determination
F. marcucci, L. Colombo, E. Mussini
Journal of Chromatography B Biomedical Sciences and Applications, 1984
Determination of creatine in body fluids and muscle
Emilio Mussini, Laura Colombo, Gloria De Ponte, Franca Marcucci
Journal of Chromatography B Biomedical Sciences and Applications, 1984
Decrease in N‐Acetyl‐l‐Aspartic Acid in Brain of Myodystrophic Mice
Franca Marcucci, Laura Colombo, Gloria De Ponte, Emilio Mussini
Journal of Neurochemistry, 1984
Low 3-methylhistidine levels in skeletal muscles of genetically dystrophic mice
Research Communications in Chemical Pathology and Pharmacology, 1984
Gas chromatographic-mass spectrometric characterization of N-methylated basic amino acids in human urine
F. Marcucci, L. Colombo, G. De Ponte, D. Cani, L. Cobelli, A. Frigerio, E. Mussini
Journal of Chromatography B Biomedical Sciences and Applications, 1984
Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3‐methylhistidine excretion in the urine
Emilio Mussini, Ferdinando Cornelio, Laura Colombo, Gloria de Ponte, Giovanni Giudici, Laura Cotellessa, Franca Marcucci
Muscle Nerve, 1984
Content of methylhistidines in normal and pathological human skeletal muscles
Emilio Mussini, Ferdinando Cornelio, Federica Dworzak, Laura Cotellessa, Lucia Morandi, Laura Colombo, Gloria De Ponte, Franca Marcucci
Muscle Nerve, 1983
Glass capillary quantitative determination of Nπ-methylhistidine in urine and muscles
E. Mussini, L. Cotellessa, L. Colombo, D. Cani, P. Sfondrini, F. Marcucci, F. Poy
Journal of Chromatography B Biomedical Sciences and Applications, 1981
Glass capillary gas chromatographic determination of Nτ-methylhistidine in urine
L. Cotellessa, F. Marcucci, D. Cani, P. Sfondrini, L. Colombo, E. Mussini, F. Poy
Journal of Chromatography B Biomedical Applications, 1980