Shardendu Kumar Mishra

@kiet.edu

Associate Professor
KIET School of Pharmacy, KIET Group of Institutions

Shardendu Kumar Mishra


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https://researchid.co/shardendu_84
Experienced Researcher with a demonstrated history of working in the field of Experimental and Clinical Pharmacology. Skilled in Pre-Pharmacology, Phytochemistry, Ethnopharmacology, Molecular biology techniques, Good Laboratory Practice (GLP), Lecturing, Pharmacological Research, and Pharmacovigilance. Strong research professional with Doctoral degree in Pharmacology from Institute of Medical Sciences, Banaras Hindu University and Master's focused in Pharmacology from West Bengal University of Technology.

EDUCATION

PhD in Pharmacology from the Institute of Medical Sciences, Banaras Hindu University

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacy, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Cellular and Molecular Neuroscience
20

Scopus Publications

498

Scholar Citations

10

Scholar h-index

11

Scholar i10-index

Scopus Publications

  • Neuropharmacological activities of 7,11-dimethyl-3-methylidenedodeca-1,6,10-triene, isolated from Elephantopus scaber Linn.
    Preeti Avasthi, Sujata Kumari, Sunil Dutt, Devinder Kumar, Pankaj Kalia, et al.
    Pharmacological Research Natural Products, 2026
  • Frankincense unveiled: Phytochemistry, bioactivity, and future directions
    Shardendu Kumar Mishra, Deepali Pandey, Omkar S. Nille, Shital J. Rajmane, Guruprasad C. Nille
    Phytomedicine Plus, 2025
  • Characterization and potential novel applications of zinc-based traditional medicine, Yashad Bhasma
    Guruprasad C. Nille, Monisha Bhuyan, Laxmi Narayan Gupta, Mohd Ali, Chandra Shekhar Pati Tripathi, et al.
    Journal of Ayurveda and Integrative Medicine, 2025
  • Leveraging Deep Learning Models for Enhanced Detection of Early-Stage Lung Cancer in CT Scan Images
    Bharti Chugh, Karnika Dwivedi, Monika Lamba, Pankaj Bhatt, Shardendu kumar Mishra, et al.
    Icdt 2025 3rd International Conference on Disruptive Technologies, 2025
    Patients afflicted with lung cancer have a high mortality rate, making it a deadly condition. It is possible to save patients' lives by detecting this disease early and correctly determining the stage of lung cancer. Medical professionals face challenges when it comes to accurately and quickly diagnosing lung cancer using various image processing, biomarker-based, and machine automation methodologies. This research makes use of CT scan images extracted from lung images acquired at a hospital. Traditional approaches rely on the patient's permission before providing CT scan images to diagnose lung cancer. Lung Cancer Cell Detection using Fusion Neural Network (LCCDC-FNN) is a new approach to early and accurate diagnosis that is proposed in this research article. Deep neural networks are employed to extract the features from the CT scan images. To save patients from this deadly disease, accurate feature extraction is crucial for early detection of malignant cells. This research aims to improve diagnostic accuracy by using an advanced 3D-convolution neural network (3D-CNN) in conjunction with U-Net and Mask R-CNN. Differentiating between benign and malignant tumors is also made possible by the proposed method. The results validate the feasibility of the suggested hybrid deep learning (DL) method for early detection of lung cancer when assessed using conventional statistical methods. The empirical results obtained from the proposed mechanism demonstrate that the proposed improved model provides U-Net, R-CNN and 3D-CNN classifications with 83.4%, 70% and 80.3% accuracy and LCCDC-FNN has accuracy of 98.99%.
  • Role of Personalized Medicine in Clinical Practice: An Overview of Current and Future Perspectives
    Roma Ghai, Ashu Mittal, Deepali Pandey, Md Shamshir Alam, Shikha Kaushik, et al.
    Biomedical and Pharmacology Journal, 2024
    Drug administration at similar doses in patients can often lead to various clinical responses. It has been hypothesized that genetics primarily accounts for variation in drug efficacy and toxicity in individuals. Personalized medicine has been a breakthrough achieved by the Human Genome Project which contributes to enhancing quality-based patient care. It deals with the customization of medication considering the distinct genetic and proteomic data that underpins the originality of every patient and every instance of therapeutic intervention. Many cases have shown that inter-individual differences related to drug response can be traced to genetic polymorphism in the gene alleles that codes for metabolizing enzymes, drug transporters, and genetic variations in a person’s Major Histocompatibility Complex (MHC). So, the paper throws an insight into epidemiological variations due to genetics, variations in response based on metabolic parameters, and transporters. It also covers genetic variation related to immune-related drug toxicities. Pharmacogenetic testing plays an important role in achieving more precise personalized therapeutics for better public health. The paper discusses various tests for human leukocyte antigen variants and metabolic variants. Every technology inclusion comes with advantages and limitations so personalized medicine also faces certain challenges which are discussed in the paper. Once personalized medicine is used in clinical settings, patients will be able to receive the best medications for them based on their unique genetic and protein profiles.
  • Design and development of a poly-herbal spray formulation and its physicochemical and biological profiling: from classic to modern drug delivery system
    Shruti Pandey, Shardendu Mishra, Brahmeshwar Mishra, Anand, Kumar Chaudhary
    Indian Journal of Traditional Knowledge, 2024
    Many of the polyherbal formulations are described in ayurvedic classics for inflammation and pains. Among them rasna saptak kwath gives best therapeutic effect in clinical studies but palatable issue makes it less popular among patients. The present work emphasizes on the transformation of this classical formulation into more convenient and acceptable form for the patients without disturbing its efficacy. In the present study kwath was converted into mechanical spray form for pain and inflammation. The extractions of herbs were done by both classical and modern methods. The mechanical spray solution was prepared with permeation enhancer, humectant, in suitable solvent system. The spray was standardized on various parameters like viscosity, evaporation time, and spray pattern. Spray was also evaluated for in vitro drug release, anti inflammatory, analgesic and skin irritation study. In the result, the spray pattern was found uniform and evaporation time was 9.81±0.30 min. The fluxes for spray were found to be 2.82±.0.11 (µg/cm 2 /h). The kinetic model for spray best fitted to zero order permeation at a constant flux for spray r>0.98. The spray also provides good results in pain and inflammation. So, here is the possibility of replacing that sticky oil of Ayurveda with spray for good relief. The products show the path for a new generation of Ayurvedic dosage form, which has the bright future in this busy schedule of life where integrity of Ayurvedic medicines not hampered.
  • Lipid-Based Nanocarriers for Brain Delivery of Drugs in Neurodegenerative Disorders
    Mukesh Kumar Yadav, Manish Singh, Pritee Chaudhary, Shardendu Kumar Mishra
    Nanoarchitectonics for Brain Drug Delivery, 2024
  • Galangal - A promising herb in Ayurvedic formulations: Phytochemistry and pharmacological evaluations
    Guruprasad C. Nille, Shardendu Kumar Mishra, Omkar S. Nille, Angad Kumar Singh, Anand Kumar Chaudhary
    Chemistry Biological Activities and Therapeutic Applications of Medicinal Plants in Ayurveda, 2022
    Galangals, the commonly used designation for three different species, namely Alpinia galanga (L.) Willd. (greater galangal), Alpinia officinarum Hance, and Alpinia calcarata Roscoe (lesser galangals), are widely used medicinal plants with a prevalent traditional name, Rasna, in Ayurveda. They are substitutes for each other in the name of Rasna in many Ayurvedic formulations. In the Ayurveda system of medicine, Rasna has effectively been used to manage various inflammatory disorders, neurodegenerative diseases, diarrhoea, stomachache, diabetes, dementia, fever, bronchial catarrh, etc. The principal phytochemicals in galangals are alkaloids, terpenoids, flavonoids, coumarins, saponins, tannins, essential oils, apigenin, chrysin, galangin-3-methyl ether, galangin, zingerone, diterpene, diterpene B, 1,8-cineol, α-pinene, galangoisoflavonoid, 1′-acetoxyeugenol acetate, protocatechuic acid, etc. Galangals are cited for their antimicrobial, antidiabetic, anti-inflammatory, antipyretic, anticancer, antispasmodic, antiviral, antifungal, cytoprotective, hepatoprotective, neuroprotective, aphrodisiac, antiemetic, antihelminthic, antiulcerative, antidiuretic, antidementia, and antiallergic properties. This chapter aims to provide comprehensive data about galangals by addressing details of the species and their present utility in various Ayurvedic formulations. It also includes their ethnomedicinal, phytochemical, and pharmacological aspects.
  • Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property
    Guruprasad C. Nille, Shardendu Kumar Mishra, Anand Kumar Chaudhary, K. R. C. Reddy
    Frontiers in Pharmacology, 2021
    Avartaki (Senna auriculata(L.) Roxb. syn.Cassia auriculataL.; Family- Fabaceae ) is a traditional medicinal plant, widely used for the treatment of various ailments in Ayurveda and Siddha system of medicine in India. Almost all the parts of the plant, such as flowers, leaves, seeds, barks, and roots have been reported for their medicinal uses. Traditionally, it has been used in the treatment of diabetes, asthma, rheumatism, dysentery, skin disease, and metabolic disorders. The principle phytochemicals inSenna auriculata(L.) Roxb. are alkaloids, anthraquinone, flavone glycosides, sugar, saponins, phenols, terpenoids, flavonoids, tannins, steroids, palmitic acid, linoleic acid, benzoic acid 2-hydroxyl methyl ester, 1-methyl butyl ester, resorcinol, α-tocopherol-β-D-mannosidase, epicatechin, ferulic acid, quercetin-3-O-rutinoside, quercetin, proanthocyanidin B1. The extracts from its different parts and their isolated compounds possess a wide range of pharmacological activities such as antidiabetic, antioxidant, anti-inflammatory, antihyperlipidemic, hepatoprotective, nephroprotective, cardioprotective, anti-atherosclerotic, anticancer, antimutagenic, antimicrobial, antiulcer, antipyretic, anthelmintic, immunomodulatory, antifertility, anti-venom, and anti-melanogenesis. The toxicological findings from preclinical studies ensured the safety of the plant, but comprehensive clinical studies are required for the safety and efficacy of the plant in humans. The current review article aimed to provide up-to-date information aboutSenna auriculata(L.) Roxb. covering its ethnomedicinal, phytochemical, pharmacological, and toxicological aspects with special emphasis on its clinical implications in diabetes.
  • Antinociceptive, anti inflammatory and antiarthritic activity of ethanol root extract and fraction of Aganosma dichotoma (Roth) K. Schum
    Indian Journal of Experimental Biology, 2018
  • Phytochemical screening, antioxidant activity and characterization of polyherbal extract by attenuated total reflectance and gas chromatography-mass spectrometry
    International Journal of Green Pharmacy, 2018
  • Antiurolithic activity of different fractions of Aganosma dichotoma as folk medicine of Andhra Pradesh
    International Journal of Green Pharmacy, 2017
  • Drug development against tuberculosis: Impact of alkaloids
    Shardendu K. Mishra, Garima Tripathi, Navneet Kishore, Rakesh K. Singh, Archana Singh, et al.
    European Journal of Medicinal Chemistry, 2017
  • Phytochemical screening, free radical scavenging, antimicrobial activity of ethanolic extract of Leptadenia pyrotechnica
    International Journal of Green Pharmacy, 2017
  • Hypoglycemic effect of Talapotaka Churna in streptozotocin-induced hyperglycemia in rats
    International Journal of Green Pharmacy, 2016
  • Comparative antidiabetic investigation of Talapotaka Churna and Avartaki Churna in STZ-induced diabetic rats
    Asian Journal of Pharmaceutics, 2016
  • Natural dyes with future aspects in dyeing of textiles: A research article
    International Journal of Pharmtech Research, 2015
  • A preliminary evaluation of comparative effectiveness of riluzole in therapeutic regimen for irritable bowel syndrome
    Surya Prakash Mishra, Sunit Kumar Shukla, Bajrang Lal Pandey
    Asian Pacific Journal of Tropical Biomedicine, 2014
  • Measurement of lens autofluorescence can distinguish subjects with diabetes from those without
    Frederick Cahn, John Burd, Keith Ignotz, Shardendu Mishra
    Journal of Diabetes Science and Technology, 2014
  • 5-HT2A receptor binding and antidepressant studies on Anximin®, a polyherbal formulation
    Pharmacologyonline, 2008

RECENT SCHOLAR PUBLICATIONS

  • Frankincense Unveiled: Phytochemistry, Bioactivity, and Future Directions
    SK Mishra, D Pandey, OS Nille, SJ Rajmane, GC Nille
    Phytomedicine Plus, 100898 , 2025
    2025
    Citations: 3
  • Characterization and potential novel applications of zinc-based traditional medicine, Yashad Bhasma
    GC Nille, M Bhuyan, LN Gupta, M Ali, CSP Tripathi, OS Nille, SK Mishra, ...
    Journal of Ayurveda and Integrative Medicine 16 (5), 101188 , 2025
    2025
  • Leveraging Deep Learning Models for Enhanced Detection of Early-Stage Lung Cancer in CT Scan Images
    B Chugh, K Dwivedi, M Lamba, P Bhatt, S kumar Mishra, J Lamba
    2025 3rd International Conference on Disruptive Technologies (ICDT), 1568-1572 , 2025
    2025
    Citations: 3
  • Impact of Cross‐Linking on the Physicochemical and Physiological Characteristics of Barnyard Millet ( Echinochloa frumentacea ) Grains Starch
    P Bhatt, S Singh, S Garg, P Ashoka, SK Mishra, S Kaushik, V Deva, ...
    Starch‐Stärke 77 (1), 2300285 , 2025
    2025
    Citations: 22
  • Design and development of a poly-herbal spray formulation and its physicochemical and biological profiling: from classic to modern drug delivery system
    S Pandey, S Mishra, B Mishra, AK Chaudhary
    Indian Journal of Traditional Knowledge (IJTK) 23 (10), 970-976 , 2024
    2024
    Citations: 2
  • Assessing the Protective Effects of PC-1 Formulation on Ethanol-Induced Gastric Ulcer Model in Wistar Rats: A Comprehensive Study.
    VK CHOUdHARY, SK MISHRA, G KAPOOR, S CHAUdHARY, R GHAI, ...
    Oriental Journal of Chemistry 40 (5), 1269-1280 , 2024
    2024
  • Herbal Remedies in Wound Healing: A Comprehensive Review of Plants and Non-Clinical Applications (Mini Review).
    G GOYAL, V KUMAR, H TYAGI, P VARSHNEY, SK MISHRA, ...
    Oriental Journal of Chemistry 40 (2) , 2024
    2024
    Citations: 8
  • Lipid-Based Nanocarriers for Brain Delivery of Drugs in Neurodegenerative Disorders
    MK Yadav, M Singh, P Chaudhary, SK Mishra
    Nanoarchitectonics for Brain Drug Delivery, 148-171 , 2024
    2024
  • Nanoarchitectonics for brain drug delivery
    AK Singh, VK Chaturvedi, J Singh
    CRC Press , 2024
    2024
    Citations: 2
  • Integrating network pharmacology and molecular docking techniques to uncover the repurposing mechanism of budipine for hypertensive disease treatment
    S Chaudhary, G Kapoor, VK Choudhary, R Bhutani, K Nagarajan, ...
    Asian Journal of Pharmaceutical Research and Health Care 16 (1), 50-57 , 2024
    2024
    Citations: 3
  • An Investigative Study of Medicinal Herbs for Anti-obesity Potential:(A-Review).
    R Ghai, S CHAUdHARY, K Nagarajan, R Goel, SK Mishra, NK Tholia, ...
    Oriental Journal of Chemistry 39 (6) , 2023
    2023
    Citations: 6
  • Artificial Intelligence in Pharmaceutical Industry: Revolutionizing Drug Development and Delivery
    VKSK Pankaj Bhatt, Suruchi Singh*, Vipin Kumar, K. Nagarajan, Shardendu ...
    The Chinese Journal of Artificial Intelligence 1 (1), 1 , 2023
    2023
    Citations: 87
  • Qualitative phytochemical characterization and free radical scavenging activity of Talapotaka churna
    GC Nille, SK Mishra, KRC Reddy
    International Journal of Ayurveda Research 4 (1), 42-47 , 2023
    2023
    Citations: 3
  • Galangal–a Promising Herb in Ayurvedic Formulations: Phytochemistry and Pharmacological Evaluations
    GC Nille, SK Mishra, OS Nille, AK Singh, AK Chaudhary
    2022
    Citations: 3
  • Assessment Of Anti-Arthritic Activity Of Alcoholic & Hydroalcoholic Extract Of Inula Racemosa Hook. F In Fca Induced Arthritis In Wistar Rats.
    PK Dixit, SK Mishra, V Kumar, SK Chauhan, K Nagarajan, R Goel, P Bhatt
    Journal of Pharmaceutical Negative Results 13 , 2022
    2022
  • An epidemiological investigation of insomnia: A survey
    R Ghai, R Ghai, C Sharma, K Nagarajan, D Seth, A Pandey, S Kaushik, ...
    International Journal of Health Sciences 6 ((S4)), 7239–7250 , 2022
    2022
    Citations: 14
  • Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property
    GC Nille, SK Mishra, AK Chaudhary, KRC Reddy
    Frontiers in pharmacology 12, 647887 , 2021
    2021
    Citations: 66
  • Antinociceptive, anti inflammatory and antiarthritic activity of ethanol root extract and fraction of Aganosma dichotoma (Roth) K. Schum
    HS Pandey Deepali, Joshi Apurva, Mishra Shardendu, Sairam Krisnamurthy
    Indian Journal of Experimental Biology 56 (09), 646-656 , 2018
    2018
    Citations: 10
  • In Vitro Drug Release and Study of Anti-inflammatory Effect of Rasna Saptak Kwath
    S Pandey, SKM Kumar, S Purohit, B Mishra, C Anand
    Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J … , 2018
    2018
    Citations: 2
  • Phytochemical screening, antioxidant activity and characterization of polyherbal extract by attenuated total reflectance and gas chromatography-mass spectrometry
    BM Priyanka Purohit, Shardendu Kumar Mishra
    International Journal of Green Pharmacy 12 (2), 419 , 2018
    2018

MOST CITED SCHOLAR PUBLICATIONS

  • Artificial Intelligence in Pharmaceutical Industry: Revolutionizing Drug Development and Delivery
    VKSK Pankaj Bhatt, Suruchi Singh*, Vipin Kumar, K. Nagarajan, Shardendu ...
    The Chinese Journal of Artificial Intelligence 1 (1), 1 , 2023
    2023
    Citations: 87
  • Drug development against tuberculosis: Impact of alkaloids
    SK Mishra, G Tripathi, N Kishore, RK Singh, A Singh, VK Tiwari
    European journal of medicinal chemistry 137, 504-544 , 2017
    2017
    Citations: 74
  • Moringa oleifera : A review of the medical evidence for its nutritional and pharmacological properties
    PS Upadhyay P, Yadav MK, Mishra S, Sharma P
    International Journal of Research in Pharmacy and Science 5 (2), 12-16 , 2015
    2015
    Citations: 71
  • Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property
    GC Nille, SK Mishra, AK Chaudhary, KRC Reddy
    Frontiers in pharmacology 12, 647887 , 2021
    2021
    Citations: 66
  • Natural dyes with future aspects in dyeing of Textiles: A research article
    G Tripathi, MK Yadav, P Upadhyay, S Mishra
    International Journal of PharmTech Research 8 (1), 96-100 , 2015
    2015
    Citations: 34
  • Impact of Cross‐Linking on the Physicochemical and Physiological Characteristics of Barnyard Millet ( Echinochloa frumentacea ) Grains Starch
    P Bhatt, S Singh, S Garg, P Ashoka, SK Mishra, S Kaushik, V Deva, ...
    Starch‐Stärke 77 (1), 2300285 , 2025
    2025
    Citations: 22
  • Ethnopharmacological importance of Centella asiatica with special reference to neuroprotective activity
    G Tripathi, S Mishra, P Upadhyay, S Purohit, GP Dubey
    Asian Journal of Pharmacology and Toxicology 3 (10), 49-53 , 2015
    2015
    Citations: 20
  • Berberine a potent substance for researcher: a review
    S Preeti, U Prabhat, M Shardendu, S Ananya, P Suresh
    World J Pharm Pharm Sci 4 (07), 547-573 , 2015
    2015
    Citations: 17
  • An epidemiological investigation of insomnia: A survey
    R Ghai, R Ghai, C Sharma, K Nagarajan, D Seth, A Pandey, S Kaushik, ...
    International Journal of Health Sciences 6 ((S4)), 7239–7250 , 2022
    2022
    Citations: 14
  • Natural dyes with future aspects in dyeing of textiles: a research article
    T Gyanendra, KY Mukesh, U Prabhat, M Shardendu
    International Journal of Pharma Tech Research 8 (1), 096-100 , 2015
    2015
    Citations: 11
  • Antinociceptive, anti inflammatory and antiarthritic activity of ethanol root extract and fraction of Aganosma dichotoma (Roth) K. Schum
    HS Pandey Deepali, Joshi Apurva, Mishra Shardendu, Sairam Krisnamurthy
    Indian Journal of Experimental Biology 56 (09), 646-656 , 2018
    2018
    Citations: 10
  • Phytochemical screening, free radical scavenging, antimicrobial activity of ethanolic extract of Leptadenia pyrotechnica
    SP Shardendu Kumar Mishra, Dharmendra Kumar, Nidhi Pandey, Ragini Tilak, B ...
    International Journal of Green Pharmacy 11 (3), 180-187 , 2017
    2017
    Citations: 9
  • Herbal Remedies in Wound Healing: A Comprehensive Review of Plants and Non-Clinical Applications (Mini Review).
    G GOYAL, V KUMAR, H TYAGI, P VARSHNEY, SK MISHRA, ...
    Oriental Journal of Chemistry 40 (2) , 2024
    2024
    Citations: 8
  • Hypoglycemic effect of Talapotaka Churna in streptozotocin-induced hyperglycemia in rats
    KRCR Shardendu Mishra, Guruprasad C. Nille, Anshuman Trigunayat
    International Journal of Green Pharmacy 10 (3), 178-182 , 2016
    2016
    Citations: 7
  • An Investigative Study of Medicinal Herbs for Anti-obesity Potential:(A-Review).
    R Ghai, S CHAUdHARY, K Nagarajan, R Goel, SK Mishra, NK Tholia, ...
    Oriental Journal of Chemistry 39 (6) , 2023
    2023
    Citations: 6
  • Effect of ethanolic extract of Tinospora cordifolia on behavioral alterations induced by long term cerebral hypoperfusion in rats
    A Trigunayat, SK Mishra
    Appl Sci 5, 2630-6 , 2017
    2017
    Citations: 5
  • ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE ACTIVITY OF EXTRACT AND FRACTIONS OF LEPTADENIA PYROTECHNICA
    ATBLP Shardendu Kumar Mishra, Suresh Purohit
    European Journal of Biomedical AND Pharmaceutical sciences 4 (9), 824-832 , 2017
    2017
    Citations: 4
  • Comparative antidiabetic investigation of talapotaka churna and avartaki churna in STZ-Induced diabetic rats
    GC Nille, S Mishra, A Trigunayat, KRC Reddy
    Asian J Pharm 10, S243-29 , 2016
    2016
    Citations: 4
  • Evaluation of antidiabetic prescriptions from medical reimbursement applications at Banaras Hindu University health care facility
    D Priya, S Purohit, BL Pandey, S Mishra
    Journal of Pharmaceutical Care, 49-54 , 2014
    2014
    Citations: 4
  • Frankincense Unveiled: Phytochemistry, Bioactivity, and Future Directions
    SK Mishra, D Pandey, OS Nille, SJ Rajmane, GC Nille
    Phytomedicine Plus, 100898 , 2025
    2025
    Citations: 3