Dr.V. Kalaivani MDS

Scopus Publications

A preliminary evaluation of quercetin-mediated osteogenic gene expression in lipopolysaccharide-treated human periodontal ligament cells: an in vitro study
Srishta Radhakrishnan, Prem Blaisie Rajula M, P. L. Ravi Shankar, Merita S, V. Kalaivani, Rahila C
Bdj Open, 2026
Aim This study aimed to evaluate the effect of quercetin on osteogenic gene expression in lipopolysaccharide (LPS) stimulated human periodontal ligament cells (hPDLCs) under in vitro conditions. Materials and methods hPDLCs were cultured with LPS for 24 hours to simulate an inflammatory microenvironment. Following this pre-stimulation, cells were treated with quercetin at concentrations of 2.5 µM, 5 µM, and 10 µM for up to 14 days. No further exposure to LPS was performed during the subsequent culture period. The mRNA expression levels of osteogenic markers, osteopontin (OPN) and osteocalcin (OCN), were assessed on day 14 using Quantitative Real-Time PCR (RT-qPCR). Statistical analysis was performed using Welch’s one-way ANOVA with Holm-adjusted post hoc comparisons. Results LPS stimulation significantly suppressed the expression of both OPN and OCN compared with the control group. However, quercetin treatment restored and dose-dependently increased the expression of these markers, with the greatest effect observed at 10 µM. At this concentration, OPN and OCN expression levels reached 5.80 ± 0.26 and 6.62 ± 0.30, respectively, relative to the control. A consistent dose-dependent upregulation was observed for both markers, indicating restoration of osteogenic gene expression. Conclusion Quercetin modulates the expression of osteogenic markers, including OPN and OCN, in LPS-stimulated hPDLCs under in vitro conditions. These findings suggest a potential modulatory role for quercetin in influencing osteogenic gene expression. However, additional in vitro functional assays and in vivo studies are necessary to establish its role in periodontal regeneration.
Analysis of Fibroblast Growth Factor from Platelet-rich Fibrin with and without Phototherapy: An Ex Vivo Pilot Study
Varatharajan Kalaivani, Narayanan Vivek, Potluri Leela Ravishankar, Kunka Mohan Ramkumar, Abdul Rahim Nizar Ahmed, Kumar Gayathri
World Journal of Dentistry, 2025
products, PRF does not use any additives like anticoagulants or bovine thrombin, making it more natural and compatible with the body.It forms a special fibrin matrix packed with platelets, white blood cells, and lots of important growth factors such as PDGF, VEGF,
A Comparative Evaluation of Platelet‑derived Growth Factor in a‑PRF and a‑PRF plus, with and without Low‑level Laser Therapy – An Ex vivo Pilot Study
Varatharajan Kalaivani, Vivek Narayanan, Potluri Leela Ravishankar, Kunga Mohan Ramkumar, Nizar Ahmed, Divya Vinayachandran
Journal of Indian Academy of Oral Medicine and Radiology, 2025
Background: The application of platelet concentrates has gained significant attention in regenerative medicine and dentistry, particularly in periodontal regenerative techniques. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are platelet concentrates that facilitate the repair and regeneration of various tissues, attributed to their rich content of growth factors. Objectives: This current research aims at comparing the expression of platelet-derived growth factor (PDGF) from advanced platelet-rich fibrin (A-PRF) and advanced platelet-rich fibrin plus (A-PRF+), with and without application of low-level laser therapy (LLLT). Methods: Twenty systemically healthy subjects were included in this research. A venipuncture procedure was performed to obtain 15 millilitres of blood, which was collected from the antecubital fossa of each participant. After collection, blood was divided into two equal aliquots of 7.5 mL each. The first 7.5 mL aliquot was subjected to centrifugation for 14 minutes at 1,300 revolutions per minute (rpm), generating a relative centrifugal force of 145 g, to obtain A-PRF. The second 7.5 mL aliquot underwent centrifugation for 8 minutes at 1,300 rpm (145 g) to produce A-PRF+. Following the preparation of A-PRF and A-PRF+, each sample was divided into two equal halves. One half of the A-PRF and A-PRF+ samples was subjected to LLLT, while the other half did not receive any light treatment. After 14 days, an enzyme-linked immunosorbent assay (ELISA) was performed to quantify the expression of PDGF-BB in the samples. Results: The highest PDGF-BB levels were observed in A-PRF+ samples exposed to light (1925.09 pg/µl), followed by A-PRF with light (1905.15 pg/µl). Conclusion: The study demonstrated the expression of platelet-derived growth factor (PDGF-BB) from both A-PRF and A-PRF+ without low-level laser therapy, and a noticeable increase in production with LLLT.
Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review
Pradeep Kumar Yadalam, V. Kalaivani, Hammam Ibrahim Fageeh, Wael Ibraheem, Manea Musa. Al-Ahmari, Samar Saeed Khan, Zeeshan Heera Ahmed, Hesham H. Abdulkarim, Hosam Ali Baeshen, Thodur Madapusi Balaji, Shilpa Bhandi, A. Thirumal Raj, Shankargouda Patil
Journal of Personalized Medicine, 2022
Periodontal disease is an infection-driven inflammatory disease characterized by the destruction of tooth-supporting tissues. The establishment of chronic inflammation will result in progressive destruction of bone and soft tissue changes. Severe periodontitis can lead to tooth loss. The disease has complex pathogenesis with an interplay between genetic, environmental, and host factors and pathogens. Effective management consists of plaque control and non-surgical interventions, along with adjuvant strategies to control inflammation and disrupt the pathogenic subgingival biofilms. Recent studies have examined novel approaches for managing periodontal diseases such as modulating microbial signaling mechanisms, tissue engineering, and molecular targeting of host inflammatory substances. Mounting evidence suggests the need to integrate omics-based approaches with traditional therapy to address the disease. This article discusses the various evolving and future drug targets, including proteomics, gene therapeutics, vaccines, and nanotechnology in personalized periodontal medicine for the effective management of periodontal diseases.
Antiviral Essential Oil Components Against SARS-CoV-2 in Pre-procedural Mouth Rinses for Dental Settings During COVID-19: A Computational Study
Pradeep Kumar Yadalam, Kalaivani Varatharajan, K. Rajapandian, Priyanka Chopra, Deepavalli Arumuganainar, Thilgavathi Nagarathnam, Honglae Sohn, Thirumurthy Madhavan
Frontiers in Chemistry, 2021
COVID-19 mainly spreads through cough or sneeze droplets produced by an infected person. The viral particles are mostly present in the oral cavity. The risk of contracting COVID-19 is high in the dental profession due to the nature of procedures involved that produce aerosols. Along with other measures to limit the risk of infection, pre-procedural mouth rinses are beneficial in reducing the viral particles in the oral cavity. In this study, the antiviral efficacy of essential oil components has been determined specifically against SARS-CoV-2 by molecular docking and conceptual DFT approach. Based on the binding affinities of the components against the receptor binding domain of the S1 glycoprotein, cuminal, carvacrol, myrtanol, and pinocarveol were found to be highly active. The molecular descriptor values obtained through conceptual DFT also indicated the above-mentioned components to be active based on the correlation between the structure and the activity of the compounds. Therefore, pre-procedural mouth rinses with these components included may be specifically suitable for dental procedures during the COVID-19 period.
Gingival fenestration management: A rarefied case entity and literature review
PremB Rajula M, Kalaivani Varatharajan, Rekha Mani, Shobana Krishnakumar
Journal of Pharmacy and Bioallied Sciences, 2020
Dehiscence and fenestration are commonly confronted alveolar defects. But the combined mucosal and alveolar fenestration is uncommonly reported in the literature as they less often cause pain, and in majority of the cases, only aesthetic complaint is present. This article highlights the case report of a 28-year-old female patient who presented with aesthetic concern about gingival/mucosal fenestration in her right lower central incisor. She had a history of surgical endodontic treatment in the same tooth. In this case, mucosal fenestration was treated with regenerative therapy using bioactive glass with platelet-rich fibrin and free connective tissue graft. The treatment resulted in excellent aesthetic outcome and satisfactory bone healing.
Estimation of serum triglycerides, serum cholesterol, total protein, igg levels in chronic periodontitis affected elderly patients: A cross-sectional study
AV Saravanan, PL Ravishankar, Pradeep Kumar, K Rajapandian, V Kalaivani, MPrem Blaisie Rajula
Journal of International Society of Preventive and Community Dentistry, 2017
Aim: The present study was conducted to evaluate the serum triglycerides, serum cholesterol, total protein, and IgG levels in elderly patients who were affected by periodontal disease. Materials and Methods: This study was conducted at the Rajah Muthiah Dental College and Hospital in the periodontics division. The study was conducted for a period of 3 months. This study is a prospective analytical study. Sixty individuals who were systemically healthy in the age group of 50 and above were included in this study. Control and experimental groups of 30 participants each were included. Plaque index, gingival index, probing pocket depth, and clinical attachment loss were recorded. Biochemical parameters such as serum cholesterol, serum triglycerides, total protein, and IgG levels were also evaluated and correlated with the periodontal parameters. Data was analyzed using SPSS version 16.0 (IBM Corp., Armonk, NY). The relationship between periodontal status and the biochemical parameters such as serum cholesterol, serum triglycerides, total protein, and IgG levels were evaluated by Student′s t-test. Results: There was no significant difference in the plaque and gingival scores between the experimental and control group. It was observed that serum cholesterol level and total protein level was lower in participants suffering from chronic periodontitis. Triglycerides level was significantly elevated in the experimental group. IgG, a level which is not significant, concluded that there is no difference in control and experimental group. Conclusion: It was concluded from the results obtained from the study that there is an association between serum triglycerides, serum cholesterol, total protein, and periodontal disease. However, further longitudinal and well-controlled studies are required to evaluate the relationship between these biochemical parameters and periodontal disease.
Evaluation of anticardiolipin antibodies in tobacco users and non-tobacco users with severe chronic periodontal disease
PradeepK Yadalam, K Rajapandian, PL Ravishankar, Kalaivani Vartharajan, Srinath Subramaniam, Mithra Dinakar
Journal of International Society of Preventive and Community Dentistry, 2016
Aims: Many studies have proven that b2-glycoprotein-I-dependent anticardiolipin is elevated in periodontal diseases. Systemic lupus erythematosus and antiphospholipid syndrome, which are usually associated with high antiphospholipid antibodies, are more prone to adverse pregnancy outcomes and cardiovascular sequelae. Therefore, the aim of the present study is to evaluate IgG, IgM anticardiolipin antibodies in tobacco users and non-tobacco users with severe chronic periodontal disease. Materials and Methods: Based on the Armitage classification, 2000, 40 severe periodontitis (group D) (mean clinical attachment loss greater than 2.5 mm) male patients were selected for the study with the age range of 35–65 years and good general health from the Department of periodontics, SRM Kattankulathur Dental College, Chennai. They were classified as smokers (20 subjects) and non-smokers (20 subjects). Blood samples were collected and IgG, IgM antibodies were semi-quantitatively analyzed by enzyme-linked immunosorbent assay. The data thus collected were statistically analyzed by independent student's t-test. Results: Results showed that smokers with severe periodontitis exhibited marked increase in anticardiolipin IgG, IgM compared to non-smokers. They showed a positive correlation and statistical significance (P < 0.0001) between mean clinical attachment loss and IgG and IgM values. Conclusions: Results showed a rise in anticardiolipin antibodies in smokers with severe periodontitis, which indicates that these patients are more prone to coronary heart disease.

RECENT SCHOLAR PUBLICATIONS

Analysis of Fibroblast Growth Factor from Platelet-rich Fibrin with and without Phototherapy: An Ex Vivo Pilot Study
V Kalaivani, N Vivek, PL Ravishankar, KM Ramkumar, ARN Ahmed, ...
World Journal of Dentistry 16 (7), 655-658 , 2025
2025
Artificial Intelligence in Clinical Practice- A Narrative Review
DK Dr.Sai Sri Soury G, Dr.ViolaEsther, Dr.P.L. Ravishankar, Dr ...
International Journal Dental and Medical Sciences Research 7 (2), 121-130 , 2025
2025
A Comparative Evaluation of Platelet-derived Growth Factor in a-PRF and a-PRF plus, with and without Low-level Laser Therapy–An Ex vivo Pilot Study
V Kalaivani, V Narayanan, PL Ravishankar, KM Ramkumar, N Ahmed, ...
Journal of Indian Academy of Oral Medicine and Radiology 37 (1), 45-49 , 2025
2025
Citations: 2
Salivary Duct Cyst: A Rare Case Report
SMSR Divya Vinayachandran, Saravana Karthikeyan Balasubramanian, Sibyl ...
Advancement and New Understanding in Medical Science 2, 1-14 , 2024
2024
In vitro analysis of enamel abrasion using a novel manual nano-bristle toothbrush: An atomic force microscopy study
M Prasad, PB Rajula, S Rao, MVRM Kodali, G Soloman, N Nisha, R PL
Cureus 16 (12) , 2024
2024
Citations: 3
Evaluation of the Antimicrobial Efficacy of Ethanolic and Aqueous Extracts of Licorice (Glycyrrhiza glabra) Against a Periodontal Pathogen: An In Vitro Study
S Hariharan, K Gayathri, PL Ravishankar, V Kalaivani, AV Saravanan
Cureus 16 (11) , 2024
2024
Comparison of Antimicrobial Efficacy of Ocimum sanctum (Tulsi) Extract and Chlorhexidine Against Tannerella forsythia: An In Vitro Study
R Mithra, V Kalaivani, K Gayathri, PL Ravishankar, S Rajakumar
Cureus 16 (10) , 2024
2024
Citations: 2
Comparative Antimicrobial Efficacy of Garlic and Guava Extracts on Oral Pathogens Using a Time Kill Assay: An In Vitro Study
KMM Rashik, LR Potluri, K Varatharajan, S Raja, S Dolly, S Geddam
Journal of International Oral Health 16 (5), 380-385 , 2024
2024
Knowledge, attitudes, and practices of university students regarding the impact of smokeless tobacco, Areca nut, E-cigarette use on oral health
A Sarkar, D Vinayachandran, S Siluvai, P Gurram, LR AC, M Suresh
Cureus 16 (8) , 2024
2024
Citations: 4
Rugoscopic Evaluation of Periodontal Disease: A Cross-Sectional Study
A Sairam, V Esther, M Rashik, M Stanley, R PL
Cureus 16 (8) , 2024
2024
Evaluation of folic acid-containing mouthrinse and chlorhexidine mouthrinse as an adjunct to scaling and root planing in patients with periodontal disease
CR Aashik, K Rajapandian, K Gayathri, PL Ravishankar, V Kalaivani, ...
Cureus 16 (7) , 2024
2024
Citations: 1
Motivational Drivers in Implant Therapy: A Novel Treatment Motivation Scale
R Krishetha, S Rao, PL Ravishankar, PB Rajula, K Gayathri, V Kalaivani, ...
Cureus 16 (7) , 2024
2024
Comparison of Curcumin and Amoxicillin trihydrate Incorporated onto Guided Tissue Regeneration Membrane against Porphyromonasgingivalis: An In vitro Study
AS Ravishankar PL , Gayathri.K, Kalaivani.V, Viola Esther P.S , Prem Blaisie ...
Boletin de Literatura Oral-The Literary Journal 11 (1), 1-7 , 2024
2024
Effects of Stress on Periodontium: A Review Article
KV Sowmiya R , Rajapandian.K , Ravishankar. P. L
International Journal for Multidisciplinary Research 6 (1), 1-5 , 2024
2024
HOST MODULATION THERAPY IN PERIODONTICS A KEY COMPONENT IN MODERN PERIODONTAL CARE
DRGK DR. SINDHUJAA R, DR. P.L. RAVISHANKAR, DR. KALAIVANI.V
ISBN 979-8-89322-994-3, Notion Press Platform 1, 1-88 , 2024
2024
multiple myeloma- a recent update
LRACSM Divya Vinayachandran, Sibyl Siluvai, V. Kalaivani, Prashanthi Gurram
advancement and new understanding in medical science 1, 32-44 , 2024
2024
Association of elevated IL-6 with poor glycemic control in periodontitis patients
V Kalaivani, YP Kumar, K Rajapandian, H Parthasarthy, RV Anegundi, ...
F1000Research 12, 595 , 2023
2023
Citations: 2
Prevalence Of Temporomandibular Joint Disorders Amongst South Indian Dental School Graduates
VC Divya, C Ganesh, M Shanthi, A Backiyalakshmi, V Kalaivani
Lat. Am. J. Pharm 42, 3 , 2023
2023
Antimicrobial Efficacy Of Bis (4-Chlorophenyl) Biguanide (Chlorhexidine) And Meswak Oral Rinse Against P.Gingivalis - An Invitro Study
DMPBRMDS Dr. Haarini NK BDS, Dr. A.V. Saravanan MDS, Dr. V. Kalaivani MDS ...
Korean Journal of Physiology and Pharmacology, 27 (4), 19-25 , 2023
2023
Methamphetamine substance abuse and Dental Considerations: a modern era crisis
DSG jayssruthi.M , Madhumitha.M , Dr Divya VC, M.D.S, Dr. C. Ganesh, M.D.S ...
Korean Journal of Physiology and Pharmacology 27 (3), 337-348 , 2023
2023

MOST CITED SCHOLAR PUBLICATIONS

Antiviral essential oil components against SARS-CoV-2 in pre-procedural mouth rinses for dental settings during COVID-19: a computational study
PK Yadalam, K Varatharajan, K Rajapandian, P Chopra, ...
Frontiers in chemistry 9, 642026 , 2021
2021
Citations: 46
Role of CGF (Concentrated Growth Factor) in periodontal regeneration
RP Nityasri, Aromal S, Pradeep Kumar Y, Kalaivani V
Journal of Dental Health, Oral Disorders & Therapy 9 (5), 350-352 , 2018
2018
Citations: 42
Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review
ATRSP Pradeep Kumar Yadalam 1, V. Kalaivani 2 , Hammam Ibrahim Fageeh 3 ...
Pers. Med. 12 (1), 371 , 2022
2022
Citations: 21
TRI-IMMUNO PHASIC PERIODONTAL THERAPY
DKRDMM Dr. Y. Pradeep Kumar, Dr. V. Kalaivani*
World Journal of Pharmaceutical Research 5 (9), 356-360 , 2016
2016
Citations: 9
Nanodrug Delivery Systems in Periodontics.
PK Yadalam, D Arumuganainar, R Kasipandian, K Varatharajan
International Journal of Pharmaceutical Investigation 11 (1) , 2021
2021
Citations: 8
Estimation of serum triglycerides, serum cholesterol, total protein, igg levels in chronic periodontitis affected elderly patients: A cross-sectional study
M A.V.Saravanan,P.L.Ravishankar,Pradeep kumar Yadalam,K.Rajapandian,V.Kalaivani
Journal of international society of preventive and community dentistry 7 (2 … , 2017
2017
Citations: 7
Gingival Fenestration Management: A Rarefied Case Entity and Literature
SK Prem B. Rajula M1, Kalaivani Varatharajan1, Rekha Mani2
Journal of Pharmacy and Bioallied Sciences 12 (1), 8647-8651 , 2020
2020
Citations: 6
Knowledge, attitudes, and practices of university students regarding the impact of smokeless tobacco, Areca nut, E-cigarette use on oral health
A Sarkar, D Vinayachandran, S Siluvai, P Gurram, LR AC, M Suresh
Cureus 16 (8) , 2024
2024
Citations: 4
In vitro analysis of enamel abrasion using a novel manual nano-bristle toothbrush: An atomic force microscopy study
M Prasad, PB Rajula, S Rao, MVRM Kodali, G Soloman, N Nisha, R PL
Cureus 16 (12) , 2024
2024
Citations: 3
A Comparative Evaluation of Platelet-derived Growth Factor in a-PRF and a-PRF plus, with and without Low-level Laser Therapy–An Ex vivo Pilot Study
V Kalaivani, V Narayanan, PL Ravishankar, KM Ramkumar, N Ahmed, ...
Journal of Indian Academy of Oral Medicine and Radiology 37 (1), 45-49 , 2025
2025
Citations: 2
Comparison of Antimicrobial Efficacy of Ocimum sanctum (Tulsi) Extract and Chlorhexidine Against Tannerella forsythia: An In Vitro Study
R Mithra, V Kalaivani, K Gayathri, PL Ravishankar, S Rajakumar
Cureus 16 (10) , 2024
2024
Citations: 2
Association of elevated IL-6 with poor glycemic control in periodontitis patients
V Kalaivani, YP Kumar, K Rajapandian, H Parthasarthy, RV Anegundi, ...
F1000Research 12, 595 , 2023
2023
Citations: 2
Retracing Capacity of Pathologically Migrated Upper Anterior Teeth after Surgical Intervention
PMA S Srinath1, Y Pradeep Kumar2, P L Ravishankar3, V Kalaivani1, K Rajapandian4
Journal of International Oral Health 7 (11), 75-79 , 2015
2015
Citations: 2
Evaluation of folic acid-containing mouthrinse and chlorhexidine mouthrinse as an adjunct to scaling and root planing in patients with periodontal disease
CR Aashik, K Rajapandian, K Gayathri, PL Ravishankar, V Kalaivani, ...
Cureus 16 (7) , 2024
2024
Citations: 1
Analysis of Fibroblast Growth Factor from Platelet-rich Fibrin with and without Phototherapy: An Ex Vivo Pilot Study
V Kalaivani, N Vivek, PL Ravishankar, KM Ramkumar, ARN Ahmed, ...
World Journal of Dentistry 16 (7), 655-658 , 2025
2025
Artificial Intelligence in Clinical Practice- A Narrative Review
DK Dr.Sai Sri Soury G, Dr.ViolaEsther, Dr.P.L. Ravishankar, Dr ...
International Journal Dental and Medical Sciences Research 7 (2), 121-130 , 2025
2025
Salivary Duct Cyst: A Rare Case Report
SMSR Divya Vinayachandran, Saravana Karthikeyan Balasubramanian, Sibyl ...
Advancement and New Understanding in Medical Science 2, 1-14 , 2024
2024
Evaluation of the Antimicrobial Efficacy of Ethanolic and Aqueous Extracts of Licorice (Glycyrrhiza glabra) Against a Periodontal Pathogen: An In Vitro Study
S Hariharan, K Gayathri, PL Ravishankar, V Kalaivani, AV Saravanan
Cureus 16 (11) , 2024
2024
Comparative Antimicrobial Efficacy of Garlic and Guava Extracts on Oral Pathogens Using a Time Kill Assay: An In Vitro Study
KMM Rashik, LR Potluri, K Varatharajan, S Raja, S Dolly, S Geddam
Journal of International Oral Health 16 (5), 380-385 , 2024
2024
Rugoscopic Evaluation of Periodontal Disease: A Cross-Sectional Study
A Sairam, V Esther, M Rashik, M Stanley, R PL
Cureus 16 (8) , 2024
2024

Dr.V. Kalaivani MDS

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Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS