Spectrophotometric quantification of amitriptyline hydrochloride in pharmaceutical tablets: method development and validation Sameer A. M. Abdulrahman, Abdullah R. Al-khawlani Journal of Umm Al Qura University for Applied Sciences, 2024 The development and validation of two uncomplicated, selective, and non-extraction-based visible spectrophotometric methods was carried out for the quantification of a tricyclic antidepressant amitriptyline hydrochloride as pharmaceutical tablets as well as in its pure form. The methods rely on the formation of ion pair complexes between amitriptyline base and two acidic dyes, bromothymol blue and bromocresol purple, which were subsequently measured at 410 and 400 nm, respectively. The developed methods included numerous reaction variables that were examined and improved. Beer's law is applicable under optimal conditions for the bromothymol blue and bromocresol purple methods, respectively, over concentrations from 0.5 to 12.5 μg mL−1 and from 0.5 to 10.0 μg mL−1 amitriptyline hydrochloride. The computed values of molar absorptivity were 1.79 × 104 and 2.32 × 104 L.mol−1.cm−1 for bromothymol blue and bromocresol purple methods, respectively, with Sandell’s sensitivity values of 0.0155 and 0.0119 μg cm−2. Both detection limits and quantification limits were computed and determined to be 0.55 and 1.67 μg mL−1 for bromothymol blue method, and 0.49 and 1.49 μg mL−1 for bromocresol purple method, respectively. The developed methods were successfully applied to estimate the concentration of amitriptyline hydrochloride in bulk form and commercial pills. Therefore, these methods demonstrate promising potential for testing this drug in labs for quality control. Graphical abstract Spectrophotometric quantification of amitriptyline hydrochloride in pharmaceutical tablets: method development and validation
Assessment of Sewage Molecular Markers: Linear Alkylbenzenes in Sediments of an Industrialized Region in Peninsular Malaysia Sadeq A. A. Alkhadher, Hussein E. Al-Hazmi, Suhaimi Suratman, Mohamad P. Zakaria, Najat Masood, Bartosz Szeląg, Sami M. Magam, Ebrahim H. H. Al-Qadami, Joanna Majtacz, Przemysław Kowal, Tonni A. Kurniawan, Sameer A. M. Abdulrahman, Saeed S. Albaseer Water Switzerland, 2023 In this study, the use of linear alkylbenzenes (LABs) was employed to pinpoint the sources of human activity that cause detrimental impacts on the coastal environment and river ecosystems. LABs were detected using GC–MS in sediment samples assembled from Kim Kim River (KKR) and the Port Dickson coast (PDC). To assess the significance of variations in the distribution and concentrations of LABs across the sampling sites, this study utilized several statistical techniques such as post hoc tests, LSD techniques, analysis of variance (ANOVA), and the Pearson correlation coefficient using a significance level of p < 0.05. The degradation levels of LABs and wastewater treatment were assessed in the study using internal congeners (I/E), homologs of C13 and C12, and long-to-short-chain (L/S) ratios. The results revealed that the LAB concentrations varied between 88.3 and 112 ng/g dw in KKR and 119 to 256 ng/g dw in the PDC. Most of the surveyed areas exhibited a substantial count of C13–LABs homologs that displayed a significant difference (p < 0.05). The I/E ratios ranged from 1.7 to 2.0 in KKR and from 2.0 to 4.1 in the PDC, suggesting that the effluents originated from sources associated with the physical phase and biological phase in wastewater treatment systems (WWTSs). The results revealed that the degradation of LABs varied between 34% and 38% in KKR and between 40% and 64% in the PDC. This study underscores the importance of ongoing improvements to WWTSs and emphasizes the potential of LABs as indicators for monitoring wastewater contamination.
SENSITIVE SPECTROPHOTOMETRIC DETERMINATION OF TRIPROLIDINE HYDROCHLORIDE DRUG IN THE CAPSULES VIA ION PAIR COMPLEX FORMATION Sameer Abdulrahman, Jalal Qazzan Quimica Nova, 2023 The objective of this study was to develop two simple and selective visible spectrophotometric methods for the determination of antihistamine drug triprolidine hydrochloride (TRH) in the capsules. The methods were based on the formation of ion-pair complexes between TRH and two dyes, namely, bromocresol green (BCG) and bromophenol blue (BPB). The produced ion-pair complexes were measured at 415 and 410 nm for BCG and BPB methods, respectively. Beer’s law was applicable in the concentration ranges of 2.50-15.0 µg mL-1 TRH for both methods. The molar absorptivity values were found to be 2.12 × 104 and 2.07 × 104 L mol-1 cm-1 for the BCG method and BPB method, respectively, and the Sandell’s sensitivity values were 0.0149 and 0.0152 µg cm-2. The limits of detection and quantification were calculated and found to be 0.29 and 0.86 µg mL-1 for the BCG method and 0.31 and 0.95 µg mL-1 for the BPB method. The methods were applied successfully for TRH determination in bulk drug and in the capsules.
Application of redox reactions for the determination of valganciclovir hydrochloride in pharmaceuticals Nagib Abdullah Salem Qarah, Kanakapura Basavaiah, Sameer Abdulaziz Mohammed Abdulrahman Brazilian Journal of Pharmaceutical Sciences, 2020 Two simple, selective and sensitive spectrophotometric methods were developed and validated for the determination of valganciclovir hydrochloride (VLGH) in pure drug and tablets. The first method was based on the reduction of iron(III) to iron(II) by VLGH and subsequent formation of iron(III)-ferricyanide complex (Prussian blue) in acid medium which was measured at 730 nm (method A). In the second method (method B), permanganate was reduced by VLGH to bluish green manganate in alkaline medium and the absorbance was measured at 610 nm. The absorbance measured in each case was related to VLGH concentration. The experimental conditions were carefully studied and optimized. Beer’s law was obeyed over the concentration ranges of 2.5-20.0 and 2.0-40.0 µg mL-1 for method A and method B, respectively, with corresponding molar absorptivity values of 1.28×104 and 6.88×103 L mol-1 cm-1. The limits of detection (LOD) and quantification (LOQ) were 0.11 and 0.33 µg mL-1 (method A) and 0.21 and 0.64 µg mL-1 (method B). Within-day and between-day relative standard deviations (%RSD) at three different concentrations levels were < 2.4%, and the respective relative errors (%RE) were ≤ 3%. The proposed methods were successfully applied to the determination of VLGH in tablets, and the results confirmed that the proposed methods were equally precise and accurate as the official method.
New applications for amoxicillin determination in pure form and pharmaceuticals based on iodate-iodide mixture: Titrimetry and spectroscopy studies Nagib Qarah, Sameer Abdulrahman, Faisal Algethami, Kanakapura Basavaiah, Ezzouhra El-Maaidenen Quimica Nova, 2020 Nagib A. S. Qarah*,a, , Sameer A. M. Abdulrahmanb, Faisal K. Algethami#,c, Kanakapura Basavaiahd and Ezzouhra El-Maaidene Department of Chemistry, Faculty of Education-Zabid, Hodeidah University, Hodeidah, Yemen Department of Chemistry, Faculty of Education and Sciences-Rada’a, Al-Baydha University, Al-Baydha, Yemen Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia Department of Chemistry, University of Mysore, Manasagangothri, Mysuru-570 006, Karnataka, India Laboratory of Biochemistry and Neurosciences, Department of Biology, University Hassan 1, Settat, Morocco
Application of ion-pair complexation reaction for the spectrophotometric determination of clarithromycin in pharmaceutical formulations Thai Journal of Pharmaceutical Sciences, 2017
Sensitive spectrophotometric determination of tramadol hydrochloride in pharmaceuticals using folin-ciocalteu's reagent Turkish Journal of Pharmaceutical Sciences, 2013
Highly sensitive spectrophotometric method for the determination of gabapentin in capsules using sodium hypochloride Turkish Journal of Pharmaceutical Sciences, 2012
Utility of N-bromosuccinimide as an environmental-friendly reagent for sensitive determination of olanzapine in pharmaceuticals Jordan Journal of Pharmaceutical Sciences, 2011
Use of bromate-bromide mixture as a reagent for the determination of dothiepin hydrochloride in pharmaceuticals Thai Journal of Pharmaceutical Sciences, 2011
Sensitive and selective methods for the determination of olanzapine in pharmaceuticals using N-bromosuccinimide and two dyes International Journal of Chemtech Research, 2010
Simple and sensitive spectrophotometric determination of olanzapine in pharmaceutical formulations using two sulphonphthalein acid dyes Journal of Food and Drug Analysis, 2009
RECENT SCHOLAR PUBLICATIONS
Quantitative Spectrophotometric Analysis of Etoricoxib in Pharmaceutical Tablets Employing a Charge-Transfer Reaction Sameer A. M. Abdulrahman, Abdulrahman Z. Al-Fotaini , Jalal A. M. Qazzan Chemistry Africa , 2024 2024 Citations: 3
Microplastics in water resources: Global pollution circle, possible technological solutions, legislations, and future horizon SS Albaseer, HE Al-Hazmi, TA Kurniawan, X Xu, SAM Abdulrahman, ... Science of The Total Environment 946, 173963 , 2024 2024 Citations: 41
Spectrophotometric quantification of amitriptyline hydrochloride in pharmaceutical tablets: method development and validation SAM Abdulrahman, AR Al-khawlani Journal of Umm Al-Qura University for Applied Sciences 10 (3), 518-529 , 2024 2024 Citations: 2
Hydrochar-nanoparticle integration for arsenic removal from wastewater: challenges, possible solutions, and future horizon AK Khanzada, HE Al-Hazmi, B Śniatała, TM Joseph, J Majtacz, ... Environmental research 238, 117164 , 2023 2023 Citations: 65
Assessment of Sewage Molecular Markers: Linear Alkylbenzenes in Sediments of an Industrialized Region in Peninsular Malaysia Sadeq A. A. Alkhadher, Hussein E. Al-Hazmi, Suhaimi Suratman, Mohamad P ... Water 15 (18), 3301 , 2023 2023 Citations: 7
SENSITIVE SPECTROPHOTOMETRIC DETERMINATION OF TRIPROLIDINE HYDROCHLORIDE DRUG IN THE CAPSULES VIA ION PAIR COMPLEX FORMATION SAM Abdulrahman, JAM Qazzan Química Nova , 2023 2023 Citations: 1
Development of non-aqueous titrimetric and spectrophotometric methods for the determination of valganciclovir hydrochloride in bulk drug and tablets SAM Abdulrahman, FK Algethami, NAS Qarah, K Basavaiah, ... Annales Pharmaceutiques Françaises 79 (5), 489-499 , 2021 2021 Citations: 8
Application of redox reactions for the determination of valganciclovir hydrochloride in pharmaceuticals NAS Qarah, K Basavaiah, SAM Abdulrahman Brazilian Journal of Pharmaceutical Sciences 56, e17784 , 2020 2020 Citations: 5
New applications for amoxicillin determination in pure form and pharmaceuticals based on iodate-iodide mixture: titrimetry and spectroscopy studies NAS Qarah, SAM Abdulrahman, FK Algethami, K Basavaiah, ... Quimica Nova 43, 44-49 , 2020 2020 Citations: 12
Spectrophotometric determination of ethionamide in pharmaceuticals using Folin–Ciocalteu reagent and iron (III)-ferricyanide as chromogenic agents NAS Qarah, K Basavaiah, SAM Abdulrahman Journal of Taibah University for Science 11 (5), 718-728 , 2017 2017 Citations: 17
Application of ion-pair complexation reaction for the spectrophotometric determination of clarithromycin in pharmaceutical formulations SAM Abdulrahman Thai Journal of Pharmaceutical Sciences (TJPS) 41 (2) , 2017 2017 Citations: 2
Spectrophotometric assay of Diethylcarbamazine Citrate in Pharmaceuticals and human Urine via Ion-Pair reaction using Methyl orange dye SAM Abdulrahman, K Basavaiah Journal of Pharmaceutical Care & Health Systems 4 (04) , 2017 2017 Citations: 1
Use of picric acid and iodine as electron acceptors for spectrophotometric determination of lansoprazole through a charge-transfer complexation reaction SAM Abdulrahman, OZ Devi, K Basavaiah, KB Vinay Journal of Taibah University for Science 10 (1), 80-91 , 2016 2016 Citations: 20
Application of cerium (IV) as an oxidimetric agent for the determination of ethionamide in pharmaceutical formulations K Basavaiah, NAS Qarah, SAM Abdulrahman Journal of Pharmaceutics 2016 (1), 5410573 , 2016 2016 Citations: 12
Use of perchloric acid for the development and validation of a non-aqueous titrimetric assay of lansoprazole in pharmaceutical capsules OZ Devi, SAM Abdulrahman, K Basavaiah, KB Vinay Journal of Chemical and Pharmaceutical Research 7 (2), 685-691 , 2015 2015 Citations: 3
Utilization of bromination reactions for the determination of carbamazepine using bromate–bromide mixture as a green brominating agent K Basavaiah, SAM Abdulrahman Arabian Journal of Chemistry 7 (3), 297-305 , 2014 2014 Citations: 6
Use of alizarin red S as a chromogenic agent for the colorimetric determination of dothiepin hydrochloride in pharmaceutical formulations SAM Abdulrahman, K Basavaiah Journal of Saudi Chemical Society 18 (2), 107-114 , 2014 2014 Citations: 21
Sensitive and selective spectrophotometric methods for the determination of pheniramine maleate in bulk drug and in its formulations using sodium hypochlorite MS Raghu, K Basavaiah, SAM Abdulrahaman, KN Prashanth, KB Vinay Journal of analytical chemistry 68 (11), 969-976 , 2013 2013 Citations: 7
Sensitive spectrophotometric determination of tramadol hydrochloride in pharmaceuticals using Folin-Ciocalteu's reagent KB Vinay, HD Revenasiddappa, AM Sameer Turk. J. Pharm. Sci 10, 57-68 , 2013 2013 Citations: 15
Validation of UV spectrophotometric methods for the determination of dothiepin hydrochloride in pharmaceutical dosage form and stress degradation studies SAM Abdulrahman, K Basavaiah, MX Cijo, KB Vinay Journal of Applied Spectroscopy 79 (5), 780-787 , 2012 2012 Citations: 9
MOST CITED SCHOLAR PUBLICATIONS
Hydrochar-nanoparticle integration for arsenic removal from wastewater: challenges, possible solutions, and future horizon AK Khanzada, HE Al-Hazmi, B Śniatała, TM Joseph, J Majtacz, ... Environmental research 238, 117164 , 2023 2023 Citations: 65
Microplastics in water resources: Global pollution circle, possible technological solutions, legislations, and future horizon SS Albaseer, HE Al-Hazmi, TA Kurniawan, X Xu, SAM Abdulrahman, ... Science of The Total Environment 946, 173963 , 2024 2024 Citations: 41
Sensitive and selective spectrophotometric determination of gabapentin in capsules using two nitrophenols as chromogenic agents SAM Abdulrahman, K Basavaiah International Journal of Analytical Chemistry 2011 (1), 619310 , 2011 2011 Citations: 30
Use of charge transfer complexation reaction for the spectrophotometric determination of bupropion in pharmaceuticals and spiked human urine K Basavaiah, SAM Abdulrahman The Thai Journal of Pharmaceutical Sciences 34 (4), 134-145 , 2010 2010 Citations: 29
Simple and sensitive spectrophotometric determination of olanzapine in pharmaceutical formulations using two sulphonphthalein acid dyes K Basavaiah, SAM Abdulrahman, KB Vinay Journal of Food and Drug Analysis 17 (6), 11 , 2009 2009 Citations: 28
Titrimetric and spectrophotometric assay of bupropion hydrochloride in pharmaceuticals using mercury (II) nitrate MAS Abdulaziz, K Basavaiah, KB Vinay Ecletica quimica 35, 9-16 , 2010 2010 Citations: 23
Use of alizarin red S as a chromogenic agent for the colorimetric determination of dothiepin hydrochloride in pharmaceutical formulations SAM Abdulrahman, K Basavaiah Journal of Saudi Chemical Society 18 (2), 107-114 , 2014 2014 Citations: 21
Use of picric acid and iodine as electron acceptors for spectrophotometric determination of lansoprazole through a charge-transfer complexation reaction SAM Abdulrahman, OZ Devi, K Basavaiah, KB Vinay Journal of Taibah University for Science 10 (1), 80-91 , 2016 2016 Citations: 20
Non-aqueous titrimetric assay of gabapentin in capsules using perchloric acid as titrant SAM Abdulrahman, K Basavaiah Chemical Industry and Chemical Engineering Quarterly 17 (2), 173-178 , 2011 2011 Citations: 19
New extractive spectrophotometric methods for the determination of olanzapine in pharmaceutical formulations using bromocresol green KBV Kanakapura Basavaiah, Sameer A. M. Abdulrahman Jordan Journal of Chemistry (JJC) 5 (1), 101-117 , 2010 2010 Citations: 18
Spectrophotometric determination of ethionamide in pharmaceuticals using Folin–Ciocalteu reagent and iron (III)-ferricyanide as chromogenic agents NAS Qarah, K Basavaiah, SAM Abdulrahman Journal of Taibah University for Science 11 (5), 718-728 , 2017 2017 Citations: 17
Spectrophotometric determination of dothiepin hydrochloride in pharmaceuticals through ion-pair complexation reaction SAM Abdulrahman, K Basavaiah Chemical Industry and Chemical Engineering Quarterly 18 (2), 339-347 , 2012 2012 Citations: 17
Sensitive and selective spectrophotometric assay of gabapentin in capsules using sodium 1, 2‐naphthoquinone‐4‐sulfonate SAM Abdulrahman, K Basavaiah Drug Testing and Analysis 3 (10), 748-754 , 2011 2011 Citations: 16
Sensitive and selective methods for the determination of olanzapine in pharmaceuticals using N-bromosuccinimide and two dyes K Basavaiah, SAM Abdulrahman International Journal of ChemTech Research 2 (1), 660-668 , 2010 2010 Citations: 16
Sensitive spectrophotometric determination of tramadol hydrochloride in pharmaceuticals using Folin-Ciocalteu's reagent KB Vinay, HD Revenasiddappa, AM Sameer Turk. J. Pharm. Sci 10, 57-68 , 2013 2013 Citations: 15
Highly sensitive spectrophotometric method for the determination of gabapentin in capsules using sodium hypochloride SAM Abdulrahman, K Basavaiah Turk J. Pharm. Sci 9 (2), 113-126 , 2012 2012 Citations: 15
New applications for amoxicillin determination in pure form and pharmaceuticals based on iodate-iodide mixture: titrimetry and spectroscopy studies NAS Qarah, SAM Abdulrahman, FK Algethami, K Basavaiah, ... Quimica Nova 43, 44-49 , 2020 2020 Citations: 12
Application of cerium (IV) as an oxidimetric agent for the determination of ethionamide in pharmaceutical formulations K Basavaiah, NAS Qarah, SAM Abdulrahman Journal of Pharmaceutics 2016 (1), 5410573 , 2016 2016 Citations: 12
Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies MS Raghu, K Basavaiah, PJ Ramesh, SAM Abdulrahman, KB Vinay Journal of Applied Spectroscopy 79 (1), 131-138 , 2012 2012 Citations: 10
Validation of UV spectrophotometric methods for the determination of dothiepin hydrochloride in pharmaceutical dosage form and stress degradation studies SAM Abdulrahman, K Basavaiah, MX Cijo, KB Vinay Journal of Applied Spectroscopy 79 (5), 780-787 , 2012 2012 Citations: 9