Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model Sameer Kumar Verma, Saurabh Bhardwaj, Kishore Singh Patel, B. Kiran Naik Physics of Fluids, 2026 This work presents a computational approach to investigate antiviral aerosol deposition in anatomically realistic human airways under various physiological inhalation conditions. Antiviral drugs are represented as fine droplets that form a thin coating on airway surfaces, primarily targeting early infection sites. The suggested method combines an Eulerian–Lagrangian discrete phase model (DPM) to track droplet motion and an Eulerian wall film (EWF) model to mimic the evolution of deposited liquid films. This combination effectively addresses the shortcomings of previous studies that employed DPM exclusively, which ignored the post-deposition redistribution dynamics of liquid drugs on airway surfaces. To the best of our knowledge, this is the first study to integrate a DPM–EWF framework within a realistic airway model under both healthy and disease-specific inhalation conditions to predict drug delivery. The study assesses airflow parameters, film thickness, deposition efficiency, and surface area coverage for aerosol particles from 1 to 10 μm. Results reveal that distressed breathing patterns of chronic obstructive pulmonary disease patients significantly alter the deposition preferences between the upper (∼5.28%) and lower lobes (∼2.52%) compared to the equivalent ideal (upper: ∼3.31%, lower: ∼4.32%) and realistic healthy (upper: ∼3.80%, lower: ∼6.79%) inhalations. Moreover, the distressed breathing also limits the drug penetration into deeper generations, as the highest surface coverage is observed at the carinal region rather than the usual left lower lobe found in ideal and realistic healthy breathing cases. Such deposition contrasts highlight the importance of optimizing inhalation therapy and device designs for individuals with obstructive airway diseases.
(, 10.1101/2023.01.13.523948) Saurabh Bhardwaj, Brent A. Craven, Jacob E. Sever, Francesco Costanzo, Scott D. Simon, Keefe B. Manning Frontiers in Medical Technology, 2024 In the published article, there was an error in Figure 3b as published. The simulation was based on an incorrect scale and the values have been updated. The corrected Figure 3b and its caption appear below. In the published article, there was an error in Figure 5 as published. The simulation was conducted using an incorrect scale and these values have been revised. The corrected Figure 5 and its caption appear below. In the published article, there was an error in Table 2 as published. The simulation was conducted using an incorrect scale and these values have been revised. The corrected Table 2 and its caption appear below.In In the published article, there was an error in Table 3 as published. The simulation was conducted using an incorrect scale and these values have been revised. The corrected
Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels Ron Bessler, Saurabh Bhardwaj, Daniel Malka, Rami Fishler, Josué Sznitman Scientific Reports, 2023 Large amounts of net electrical charge are known to accumulate on inhaled aerosols during their generation using commonly-available inhalers. This effect often leads to superfluous deposition in the extra-thoracic airways at the cost of more efficient inhalation therapy. Since the electrostatic force is inversely proportional to the square of the distance between an aerosol and the airway wall, its role has long been recognized as potentially significant in the deep lungs. Yet, with the complexity of exploring such phenomenon directly at the acinar scales, in vitro experiments have been largely limited to upper airways models. Here, we devise a microfluidic alveolated airway channel coated with conductive material to quantify in vitro the significance of electrostatic effects on inhaled aerosol deposition. Specifically, our aerosol exposure assays showcase inhaled spherical particles of 0.2, 0.5, and 1.1 μm that are recognized to reach the acinar regions, whereby deposition is typically attributed to the leading roles of diffusion and sedimentation. In our experiments, electrostatic effects are observed to largely prevent aerosols from depositing inside alveolar cavities. Rather, deposition is overwhelmingly biased along the inter-alveolar septal spaces, even when aerosols are charged with only a few elementary charges. Our observations give new insight into the role of electrostatics at the acinar scales and emphasize how charged particles under 2 µm may rapidly overshadow the traditionally accepted dominance of diffusion or sedimentation when considering aerosol deposition phenomena in the deep lungs.
In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model Eliram Nof, S. Bhardwaj, P. Koullapis, Ron Bessler, S. Kassinos, J. Sznitman Plos Computational Biology, 2023 There exists an ongoing need to improve the validity and accuracy of computational fluid dynamics (CFD) simulations of turbulent airflows in the extra-thoracic and upper airways. Yet, a knowledge gap remains in providing experimentally-resolved 3D flow benchmarks with sufficient data density and completeness for useful comparison with widely-employed numerical schemes. Motivated by such shortcomings, the present work details to the best of our knowledge the first attempt to deliver in vitro–in silico correlations of 3D respiratory airflows in a generalized mouth-throat model and thereby assess the performance of Large Eddy Simulations (LES) and Reynolds-Averaged Numerical Simulations (RANS). Numerical predictions are compared against 3D volumetric flow measurements using Tomographic Particle Image Velocimetry (TPIV) at three steady inhalation flowrates varying from shallow to deep inhalation conditions. We find that a RANS k-ω SST model adequately predicts velocity flow patterns for Reynolds numbers spanning 1’500 to 7’000, supporting results in close proximity to a more computationally-expensive LES model. Yet, RANS significantly underestimates turbulent kinetic energy (TKE), thus underlining the advantages of LES as a higher-order turbulence modeling scheme. In an effort to bridge future endevours across respiratory research disciplines, we provide end users with the present in vitro–in silico correlation data for improved predictive CFD models towards inhalation therapy and therapeutic or toxic dosimetry endpoints.
A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation Raviv Allon, Saurabh Bhardwaj, Josué Sznitman, Hagit Shoffel-Havakuk, Sapir Pinhas, Elchanan Zloczower, Yael Shapira-Galitz, Yonatan Lahav Pharmaceutics, 2023 Subglottic stenosis represents a challenging clinical condition in otolaryngology. Although patients often experience improvement following endoscopic surgery, recurrence rates remain high. Pursuing measures to maintain surgical results and prevent recurrence is thus necessary. Steroids therapy is considered effective in preventing restenosis. Currently, however, the ability of trans-oral steroid inhalation to reach and affect the stenotic subglottic area in a tracheotomized patient is largely negligible. In the present study, we describe a novel trans-tracheostomal retrograde inhalation technique to increase corticosteroid deposition in the subglottic area. We detail our preliminary clinical outcomes in four patients treated with trans-tracheostomal corticosteroid inhalation via a metered dose inhaler (MDI) following surgery. Concurrently, we leverage computational fluid-particle dynamics (CFPD) simulations in an extra-thoracic 3D airway model to gain insight on possible advantages of such a technique over traditional trans-oral inhalation in augmenting aerosol deposition in the stenotic subglottic region. Our numerical simulations show that for an arbitrary inhaled dose (aerosols spanning 1–12 µm), the deposition (mass) fraction in the subglottis is over 30 times higher in the retrograde trans-tracheostomal technique compared to the trans-oral inhalation technique (3.63% vs. 0.11%). Importantly, while a major portion of inhaled aerosols (66.43%) in the trans-oral inhalation maneuver are transported distally past the trachea, the vast majority of aerosols (85.10%) exit through the mouth during trans-tracheostomal inhalation, thereby avoiding undesired deposition in the broader lungs. Overall, the proposed trans-tracheostomal retrograde inhalation technique increases aerosol deposition rates in the subglottis with minor lower-airway deposition compared to the trans-oral inhalation technique. This novel technique could play an important role in preventing restenosis of the subglottis.
Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation Saurabh Bhardwaj, Brent A. Craven, Jacob E. Sever, Francesco Costanzo, Scott D. Simon, Keefe B. Manning Frontiers in Medical Technology, 2023 Acute ischemic stroke (AIS) is a leading cause of mortality that occurs when an embolus becomes lodged in the cerebral vasculature and obstructs blood flow in the brain. The severity of AIS is determined by the location and how extensively emboli become lodged, which are dictated in large part by the cerebral flow and the dynamics of embolus migration which are difficult to measure in vivo in AIS patients. Computational fluid dynamics (CFD) can be used to predict the patient-specific hemodynamics and embolus migration and lodging in the cerebral vasculature to better understand the underlying mechanics of AIS. To be relied upon, however, the computational simulations must be verified and validated. In this study, a realistic in vitro experimental model and a corresponding computational model of the cerebral vasculature are established that can be used to investigate flow and embolus migration and lodging in the brain. First, the in vitro anatomical model is described, including how the flow distribution in the model is tuned to match physiological measurements from the literature. Measurements of pressure and flow rate for both normal and stroke conditions were acquired and corresponding CFD simulations were performed and compared with the experiments to validate the flow predictions. Overall, the CFD simulations were in relatively close agreement with the experiments, to within ±7% of the mean experimental data with many of the CFD predictions within the uncertainty of the experimental measurement. This work provides an in vitro benchmark data set for flow in a realistic cerebrovascular model and is a first step towards validating a computational model of AIS.
Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model Saurabh Bhardwaj, Pantelis Koullapis, Stavros C. Kassinos, Josué Sznitman European Journal of Pharmaceutical Sciences, 2022 Despite the prevalence of inhalation therapy in the treatment of various respiratory diseases, predicting and optimizing lung deposition fractions of inhaled drugs for maximal efficacy remains challenging due to the complex anatomical structures of the extra-thoracic airways, notably the glottal region. One of the widespread speculations in current insilico simulations lies in assuming a static glottis during inhalation, while in reality inhalation leads to significant glottis cross-sectional area expansion. The present work attempts to explore, insilico, the influence of transient movement of the glottal structures on inhalation therapy outcomes. To this end, we adopted a CT-based realistic human tracheobronchial tree (TB) model and explored transient airflows and deposition outcomes for a broad range of inhaled aerosols (i.e., dp=1-12 μm) under a dry powder inhaler (DPI) maneuver. Three different glottal expansion ratios, spanning static to 40 percent cross-sectional area expansion have been considered for the analysis. Our findings point to the tangible impact of glottal motion on airflow and particle deposition along the respiratory tract for a DPI maneuver, where a static glottis underpredicts the total particle deposition in the TB model for lower sized particles (dp≤ 3 μm) compared to predictions for all dynamic glottal motions. In contrast, for larger size particles (i.e., 5 ≤ dp≤ 10 μm), a static glottis yields lower total deposition in the TB model compared with dynamic glottal motions. Our study also underlines that regional deposition of smaller micron-sized particles is most affected by glottal deformation in the conducting airways.
Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti-inflammatory therapeutics Eliram Nof, Arbel Artzy‐Schnirman, Saurabh Bhardwaj, Hadas Sabatan, Dan Waisman, Ori Hochwald, Maayan Gruber, Liron Borenstein‐Levin, Josué Sznitman Bioengineering and Translational Medicine, 2022 Mortality rates among patients suffering from acute respiratory failure remain perplexingly high despite the maintenance of blood oxygen homeostasis during ventilatory support. The biotrauma hypothesis advocates that mechanical forces from invasive ventilation trigger immunological mediators that spread systemically. Yet, how these forces elicit an immune response remains unclear. Here, a biomimetic in vitro three‐dimensional (3D) upper airways model allows to recapitulate lung injury and immune responses induced during invasive mechanical ventilation in neonates. Under such ventilatory support, flow‐induced stresses injure the bronchial epithelium of the intubated airways model and directly modulate epithelial cell inflammatory cytokine secretion associated with pulmonary injury. Fluorescence microscopy and biochemical analyses reveal site‐specific susceptibility to epithelial erosion in airways from jet‐flow impaction and are linked to increases in cell apoptosis and modulated secretions of cytokines IL‐6, ‐8, and ‐10. In an effort to mitigate the onset of biotrauma, prophylactic pharmacological treatment with Montelukast, a leukotriene receptor antagonist, reduces apoptosis and pro‐inflammatory signaling during invasive ventilation of the in vitro model. This 3D airway platform points to a previously overlooked origin of lung injury and showcases translational opportunities in preclinical pulmonary research toward protective therapies and improved protocols for patient care.
Human Multi-Compartment Airways-on-Chip Platform for Emulating Respiratory Airborne Transmission: From Nose to Pulmonary Acini Eliram Nof, Hikaia Zidan, Arbel Artzy-Schnirman, Odelia Mouhadeb, Margarita Beckerman, Saurabh Bhardwaj, Shani Elias-Kirma, Didi Gur, Adi Beth-Din, Shulamit Levenberg, Netanel Korin, Arie Ordentlich, Josué Sznitman Frontiers in Physiology, 2022 The past decade has witnessed tremendous endeavors to deliver novel preclinical in vitro lung models for pulmonary research endpoints, including foremost with the advent of organ- and lung-on-chips. With growing interest in aerosol transmission and infection of respiratory viruses within a host, most notably the SARS-CoV-2 virus amidst the global COVID-19 pandemic, the importance of crosstalk between the different lung regions (i.e., extra-thoracic, conductive and respiratory), with distinct cellular makeups and physiology, are acknowledged to play an important role in the progression of the disease from the initial onset of infection. In the present Methods article, we designed and fabricated to the best of our knowledge the first multi-compartment human airway-on-chip platform to serve as a preclinical in vitro benchmark underlining regional lung crosstalk for viral infection pathways. Combining microfabrication and 3D printing techniques, our platform mimics key elements of the respiratory system spanning (i) nasal passages that serve as the alleged origin of infections, (ii) the mid-bronchial airway region and (iii) the deep acinar region, distinct with alveolated airways. Crosstalk between the three components was exemplified in various assays. First, viral-load (including SARS-CoV-2) injected into the apical partition of the nasal compartment was detected in distal bronchial and acinar components upon applying physiological airflow across the connected compartment models. Secondly, nebulized viral-like dsRNA, poly I:C aerosols were administered to the nasal apical compartment, transmitted to downstream compartments via respiratory airflows and leading to an elevation in inflammatory cytokine levels secreted by distinct epithelial cells in each respective compartment. Overall, our assays establish an in vitro methodology that supports the hypothesis for viral-laden airflow mediated transmission through the respiratory system cellular landscape. With a keen eye for broader end user applications, we share detailed methodologies for fabricating, assembling, calibrating, and using our multi-compartment platform, including open-source fabrication files. Our platform serves as an early proof-of-concept that can be readily designed and adapted to specific preclinical pulmonary research endpoints.
Numerical Investigation of Free Convection in a Porous Corrugated Cavity Filled with Silver (Ag) Dispersed Nano-Fluid Saurabh Bhardwaj, Amaresh Dalal Journal of Thermal Science and Engineering Applications, 2021 The present work examines the convective heat transfer characteristics in a two-dimensional (2D) corrugated closed cavity embedded with porous media. The cavity is considered to be filled with silver dispersed water-based nano-fluid. The bottom wall is heated uniformly and non-uniformly in two different cases keeping both side corrugated walls isothermally cold with an adiabatic top wall. The various parameters are selected to perform numerical simulation in the range of solid-volume fraction, 0% ≤ ϕ ≤ 10%, 103 ≤ Ra ≤ 106, and 10−4 ≤ Da ≤ 10−2. The investigation shows that the heat transfer rate shows an increasing trend at high values of Ra and Da due to strong buoyancy forces in uniform and non-uniform heating. However, an increase in heat transfer in uniform heating is more compared to non-uniform heating. It is also observed that the nano-fluid has a great impact on the heat transfer characteristics due to its high value of thermal conductivity and irregular motion of the particles. As a result, the average Nusselt number (Nuavg) shows an increasing trend for increasing solid-volume fraction values.
Electrostatic charge effects on aerosol deposition in a multiscale in vitro one-path lung model R Bessler, T Mekler, D Malka, N Onallah, O Farhana, R Fishler, ... Physical Review Fluids 11 (5), 050501 , 2026 2026
Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model SK Verma, S Bhardwaj, KS Patel, K Naik Physics of Fluids 38 (2), 021919 , 2026 2026
Corrigendum: Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation S Bhardwaj, BA Craven, JE Sever, F Costanzo, SD Simon, KB Manning Frontiers in Medical Technology 6, 1533412 , 2025 2025
Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels R Bessler, S Bhardwaj, D Malka, R Fishler, J Sznitman Scientific Reports 13 (1), 23069 , 2023 2023 Citations: 12
EXPLORING THE ROLE OF ELECTROSTATIC EFFECTS ON INHALED AEROSOL DEPOSITION IN ALVEOLATED IN VITRO AIRWAY MODELS R Bessler, J Sznitman, R Fishler, S Bhardwaj JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY 36 (6), A6-A6 , 2023 2023
In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model E Nof, S Bhardwaj, P Koullapis, R Bessler, S Kassinos, J Sznitman PLOS Computational Biology 19 (3), e1010537 , 2023 2023 Citations: 21
A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation R Allon, S Bhardwaj, J Sznitman, H Shoffel-Havakuk, S Pinhas, ... Pharmaceutics 15 (3), 903 , 2023 2023 Citations: 5
Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation S Bhardwaj, BA Craven, JE Sever, F Costanzo, SD Simon, KB Manning Frontiers in Medical Technology 5, 1130201 , 2023 2023 Citations: 11
Modeling Flow in an In Vitro Anatomical Cerebrovascular Model with Experimental Validation S Bhardwaj, BA Craven, JE Sever, F Costanzo, SD Simon, KB Manning 2023
Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model S Bhardwaj, P Koullapis, SC Kassinos, J Sznitman European Journal of Pharmaceutical Sciences 173, 106172 , 2022 2022 Citations: 24
Human multi-compartment airways-on-chip platform for emulating respiratory airborne transmission: from nose to pulmonary acini E Nof, H Zidan, A Artzy-Schnirman, O Mouhadeb, M Beckerman, ... Frontiers in Physiology 13, 853317 , 2022 2022 Citations: 31
Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti-inflammatory therapeutics E Nof, A Artzy-Schnirman, S Bhardwaj, H Sabatan, D Waisman, ... Bioengineering & Translational Medicine , 2021 2021 Citations: 12
Numerical Analysis of Conjugate Heat Transfer in a Planar Sudden Expansion Flow A Kumar, S Bhardwaj, A Dalal, G Natarajan Journal of The Institution of Engineers (India): Series C 102 (4), 981-993 , 2021 2021
Numerical investigation of free convection in a porous corrugated cavity filled with silver (Ag) dispersed nano-fluid S Bhardwaj, A Dalal Journal of Thermal Science and Engineering Applications 13 (4), 041005 , 2021 2021 Citations: 5
In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking M Heller-Algazi, E Nof, P Das, S Bhardwaj, SC Kassinos, J Sznitman Clinical Biomechanics 80, 105138 , 2020 2020 Citations: 5
Design and process optimization studies on automobile Baking process with in house LB-FD code DPV Gonella, E Monaco, A Stadik, J Chokshi, VK SHARMA, S Bhardwaj SAE Technical Paper , 2020 2020
In silico optimization of fiber-shaped aerosols in inhalation therapy for augmented targeting and deposition across the respiratory tract L Shachar-Berman, S Bhardwaj, Y Ostrovski, P Das, P Koullapis, ... Pharmaceutics 12 (3), 230 , 2020 2020 Citations: 40
Mesoscale understanding of capillarity driven two-phase flow in a packed bed architecture S Bhardwaj, A Dalal, PP Mukherjee International Journal of Heat and Mass Transfer 136, 116-127 , 2019 2019 Citations: 8
High Accurate Heat Transfer Tasks on Example of Body in White Drying Process in Paint Shop S Bhardwaj, R Euser, A Stadik, E Monaco, VK Sharma, RK Borra WCX SAE World Congress Experience , 2019 2019 Citations: 5
Sweeping of the entrapped fluid out of the groove in a three-dimensional channel using lattice Boltzmann method S Bhardwaj, A Dalal European Journal of Mechanics-B/Fluids 72, 328-339 , 2018 2018 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Influence of wavy wall and non-uniform heating on natural convection heat transfer and entropy generation inside porous complex enclosure S Bhardwaj, A Dalal, S Pati Energy 79, 467-481 , 2014 2014 Citations: 162
Analysis of natural convection heat transfer and entropy generation inside porous right-angled triangular enclosure S Bhardwaj, A Dalal International Journal of Heat and Mass Transfer 65, 500-513 , 2013 2013 Citations: 66
Effects of the inclination angle on natural convection heat transfer and entropy generation in a square porous enclosure P Meshram, S Bhardwaj, A Dalal, S Pati Numerical Heat Transfer, Part A: Applications 70 (11), 1271-1296 , 2016 2016 Citations: 50
In silico optimization of fiber-shaped aerosols in inhalation therapy for augmented targeting and deposition across the respiratory tract L Shachar-Berman, S Bhardwaj, Y Ostrovski, P Das, P Koullapis, ... Pharmaceutics 12 (3), 230 , 2020 2020 Citations: 40
Analysis of droplet dynamics in a partially obstructed confinement in a three-dimensional channel S Bhardwaj, A Dalal, G Biswas, PP Mukherjee Physics of Fluids 30 (10) , 2018 2018 Citations: 32
Human multi-compartment airways-on-chip platform for emulating respiratory airborne transmission: from nose to pulmonary acini E Nof, H Zidan, A Artzy-Schnirman, O Mouhadeb, M Beckerman, ... Frontiers in Physiology 13, 853317 , 2022 2022 Citations: 31
Effect of undulations on the natural convection heat transfer and entropy generation inside porous right-angled triangular enclosure S Bhardwaj, A Dalal Numerical Heat Transfer Part A 67 (9), 972-991 , 2015 2015 Citations: 29
Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model S Bhardwaj, P Koullapis, SC Kassinos, J Sznitman European Journal of Pharmaceutical Sciences 173, 106172 , 2022 2022 Citations: 24
In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model E Nof, S Bhardwaj, P Koullapis, R Bessler, S Kassinos, J Sznitman PLOS Computational Biology 19 (3), e1010537 , 2023 2023 Citations: 21
Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels R Bessler, S Bhardwaj, D Malka, R Fishler, J Sznitman Scientific Reports 13 (1), 23069 , 2023 2023 Citations: 12
Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti-inflammatory therapeutics E Nof, A Artzy-Schnirman, S Bhardwaj, H Sabatan, D Waisman, ... Bioengineering & Translational Medicine , 2021 2021 Citations: 12
Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation S Bhardwaj, BA Craven, JE Sever, F Costanzo, SD Simon, KB Manning Frontiers in Medical Technology 5, 1130201 , 2023 2023 Citations: 11
Numerical investigation of two dimensional natural convection and entropy generation inside a porous square enclosure with sinusoidally heated wall P Meshram, S Bhardwaj, A Dalal Progress in Computational Fluid Dynamics , 2014 2014 Citations: 10
Mesoscale understanding of capillarity driven two-phase flow in a packed bed architecture S Bhardwaj, A Dalal, PP Mukherjee International Journal of Heat and Mass Transfer 136, 116-127 , 2019 2019 Citations: 8
Sweeping of the entrapped fluid out of the groove in a three-dimensional channel using lattice Boltzmann method S Bhardwaj, A Dalal European Journal of Mechanics-B/Fluids 72, 328-339 , 2018 2018 Citations: 7
A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation R Allon, S Bhardwaj, J Sznitman, H Shoffel-Havakuk, S Pinhas, ... Pharmaceutics 15 (3), 903 , 2023 2023 Citations: 5
Numerical investigation of free convection in a porous corrugated cavity filled with silver (Ag) dispersed nano-fluid S Bhardwaj, A Dalal Journal of Thermal Science and Engineering Applications 13 (4), 041005 , 2021 2021 Citations: 5
In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking M Heller-Algazi, E Nof, P Das, S Bhardwaj, SC Kassinos, J Sznitman Clinical Biomechanics 80, 105138 , 2020 2020 Citations: 5
High Accurate Heat Transfer Tasks on Example of Body in White Drying Process in Paint Shop S Bhardwaj, R Euser, A Stadik, E Monaco, VK Sharma, RK Borra WCX SAE World Congress Experience , 2019 2019 Citations: 5
Mesoscopic analysis of three-dimensional droplet displacement on wetted grooved wall of a rectangular channel S Bhardwaj, A Dalal European Journal of Mechanics-B/Fluids 67, 35-53 , 2018 2018 Citations: 5