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Scopus Publications

THE IMPACT OF BONE TISSUE CONDITION ON THE OUTCOMES OF DENTAL IMPLANTATION: A CLINICAL STUDY
V.M. Luchynskyi, Y.I. Luchynska, N.V. Manashchuk, M.A. Luchynskyi, H.V. Stoikevych
Ukrainian Dental Almanac, 2025
Objective. This study aimed to evaluate the results of treatment in patients with dentition defects and various bone tissue conditions using dental implants. Materials and methods. The study involved 97 pa-tients aged 18 to 59 years with confirmed low bone mineral density who underwent placement of endosse-ous dental implants. All participants were divided into two clinical groups: main group – 58 patients who re-ceived standard implant placement supplemented by the local (drip) administration of our proposed os-teotropic composition into the implant bed. In addition, this group was treated with a range of systemic phar-macological agents aimed at enhancing bone tissue remodeling processes, and comparison group – 39 pa-tients who underwent conventional implant placement according to the standard protocol, without any addi-tional pharmacological intervention. To assess the effectiveness of the applied treatment strategies, the out-comes in both groups were compared to those of a control group, which included 30 individuals with normal bone mineral density. Implant placement in this group was also carried out using the standard technique.Results. An overall evaluation of implant performance based on an integral indicator showed that after 6 months, 87,88±5,68% of the implants in the control group were stable, which was 3,7 times higher than in the comparison group (p<0,01), and 1,5 times higher than in the main group (p<0,05). In the comparison group, the number of successfully integrated implants was 2,5 times lower than in the main group (p<0,01). The number of implants with temporary mobility (grades I–II) without pathological pockets in the control group was 9,09±3,00%, which was 1,9 times lower than in the comparison group (p>0,05) and 2,3 times lower than in the main group (p<0,05). Implants with temporary mobility (grades I–II) and pathological pockets were not observed in the control group, but were detected in 16.88 ± 4.26% of cases in the comparison group and in 13.08 ± 3.25% of cases in the main group (p < 0.01; p₁ > 0.05). Notably, implants with grade III mobility and deep periodontal pockets were 4,2 times more common in the comparison group than in the main group (19,48±4,51% vs. 4,67±2,03%, p<0,01). The highest rate of implant rejection was re-corded in the comparison group, at 23,78±4,85%, compared to 3,03±0,98% in the control group and 1,87±0,30% in the main group (p<0,01). Conclusion. Thus, the clinical evaluation of implant function con-firms the effectiveness of general osteotropic therapy combined with the use of the composite “Easy-Graft+platelet-rich plasma+multipotent mesenchymal stromal cells from adipose tissue” in patients with low bone mineral density.
Comparative analysis of dysbiotic changes in the oral cavity of patients with periodontal diseases and systemic pathologies
Olha Denefil, Sofiia Chorniy, Svitlana Boitsaniuk, Natalia Chornij, Mariana Levkiv, Liudmyla Patskan, Khrystyna Pohoretska, Nadiia Manashchuk, Marta Zaliznyak, Natalia Tverdokhlib
Exploration of Medicine, 2024
Aim: This study provides a comparative analysis of oral dysbiosis of patients with periodontal diseases: chronic catarrhal gingivitis and generalized periodontitis, associated with various systemic pathologies, using a combination of the enzymatic method and interval scale. Studying the differences in the oral microbiota of patients with periodontal diseases and systemic pathologies can help comprehend the underlying mechanisms and create successful treatments. Methods: An enzymatic method was used to diagnose and monitor the degree of oral dysbiosis of patients with different systemic pathologies and periodontal diseases. We applied particular inclusion and exclusion criteria to include patients in a study. The level of microbial presence in the oral cavity can be measured by analyzing urease enzyme activity. Results: The research established that oral dysbiosis is observed in all groups of patients with periodontal diseases and systemic pathology: chronic colitis, chronic pancreatitis, and primary hypothyroidism. The article discusses an express method of diagnosing the microbiota of the oral cavity in combination with an interval scale. This combination makes it possible to classify patients according to the level of oral dysbiosis and prescribe further recommendations for treatment. Conclusions: The association of periodontitis and linked comorbidities is a complex interplay involving common risk factors, pathophysiology, and bidirectional causal relationships. The imbalance of microorganisms in the oral cavities of patients with systemic and periodontal diseases highlights the need for a personalized medical treatment approach. Correcting dysbiosis of the oral cavity should complement antimicrobial treatment for periodontal diseases and the normalization of metabolic processes in the periodontium. It has been confirmed that there is a correlation between patients’ microbial colonization of the oral cavity and the values obtained by the enzymatic method, suggesting that this approach can serve as a rapid assessment of the oral cavity’s microbiocenosis.
Analysis of microbiocenosis of a gingival sulcus and periodontal pockets of patients with periodontal diseases associated with systemic pathology
Olha Denefil, Sofiia Chorniy, Svitlana Boitsaniuk, Nadiia Manashchuk, Natalia Chornij, Mariana Levkiv, Natalia Tverdokhlib, Khrystyna Loza
Exploration of Medicine, 2023
Aim: The aim is to analyze the microbiome of gingival sulcus and periodontal pockets of patients with periodontal disease associated with systemic diseases. Methods: A microbiological study was conducted to analyze the microflora of the periodontal pockets in patients with different systemic pathologies and periodontal diseases. Plaque samples were collected from the gingival sulcus and periodontal pockets, and they were subsequently cultured on nutrient medium and glass plates. Results: The microbiota of the gingival sulcus and periodontal pockets in patients with associated systemic diseases in combination with periodontal disease was studied. The frequency of detecting the qualitative composition of the microbiota in the periodontal niche of patients with periodontal diseases and systemic diseases was determined. The research paper outlined groups of microorganisms isolated from periodontal pockets of patients with periodontal and systemic diseases. Conclusions: The degree of colonization by microorganisms differed slightly, while the frequency of detection of specific populations of opportunistic bacteria increased in chronic generalized periodontitis compared to chronic catarrhal gingivitis.
Emergence of Nano-Dentistry as a Reality of Contemporary Dentistry
Orest Kochan, Svitlana Boitsaniuk, Mariana Levkiv, Krzysztof Przystupa, Nadiia Manashchuk, Khrystyna Pohoretska, Natalia Chornij, Iryna Tsvyntarna, Liudmyla Patskan
Applied Sciences Switzerland, 2022
(1) Background. Nanotechnology offers significant alternative ways to solve scientific, medical, and human health issues. Dental biomaterials were improved by nanotechnology. It manufactures better materials or improves the existing ones and forms the basis of novel methods for disease diagnosis and prevention. Modern nanotechnology makes oral health care services more acceptable for patients. Nanotechnology is now important area of research, covering a broad range of applications in dentistry. (2) Methods. Relevant literature from Scopus published in English was selected using the keywords “nanoparticle” and “dentistry”. To the selected articles we applied the inclusion and exclusion criteria to choose the relevant ones. (3) Results. Based on the relevant articles, a literature review was prepared. This review provides an insight into the applications of nanotechnology in various branches of dentistry. We applied several regression models to fit number of papers versus time and chose the best one. We used it to construct the forecast and its 95%-confidence interval for the number of publications in 2022–2026. (4) Conclusions. It shows that a significant rise in papers is expected. This review familiarizes dentists with properties and benefits of nanomaterials and nanotechnology. Additionally, it can help scientists to consider the direction of their research and to plan prospective research projects.
Prevention and methods of correction of hyperesthesia of dental hard tissues of teeth
Pharmacologyonline, 2021

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