Andreas Haag

@research-portal.st-andrews.ac.uk

Lecturer Infection and Global Health
University of St Andrews

Andreas Haag


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https://researchid.co/andhaag
34

Scopus Publications

2092

Scholar Citations

21

Scholar h-index

29

Scholar i10-index

Scopus Publications

  • Draft genome sequence of a non-tuberculous Mycobacterium strain isolated from a clinical urine sample
    Joanna E. Rivas Ramos, Paul R. Johnston, Robert J. H. Hammond, Matthew T. G. Holden, Derek J. Sloan, Andreas F. Haag
    Access Microbiology, 2026
    Here, we report the draft sequence of a rapid-growing nontuberculous Mycobacterium isolated from a urine sample at the Scottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh, UK. The reported genome has a length of 6,749,454 bp, a G+C content of 67.2 mol% and 6,336 protein CDSs. Average nucleotide identity (ANI) analysis identified Mycobacterium vanbaalenii PYR-1 as the closest relative (83.32% ANI), indicating that this isolate likely represents a novel species within the genus. Notably, phenotypic characterization revealed a distinct antimicrobial resistance (AMR) profile. This assembly provides a valuable resource for studying the evolution of AMR mechanisms in nontuberculous mycobacteria and offers insight into resistance phenotypes observed in clinical isolates.
  • The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus
    Mohammed A. Thabet, José R. Penadés, Andreas F. Haag
    Nature Communications, 2023
    Bacteriophages (phages) are the most abundant biological entities on Earth, exerting a significant influence on the dissemination of bacterial virulence, pathogenicity, and antimicrobial resistance. Temperate phages integrate into the bacterial chromosome in a dormant state through intricate regulatory mechanisms. These mechanisms repress lytic genes while facilitating the expression of integrase and the CI master repressor. Upon bacterial SOS response activation, the CI repressor undergoes auto-cleavage, producing two fragments with the N-terminal domain (NTD) retaining significant DNA-binding ability. The process of relieving CI NTD repression, essential for prophage induction, remains unknown. Here we show a specific interaction between the ClpX protease and CI NTD repressor fragment of phages Ф11 and 80α in Staphylococcus aureus. This interaction is necessary and sufficient for prophage activation after SOS-mediated CI auto-cleavage, defining the final stage in the prophage induction cascade. Our findings unveil unexpected roles of bacterial protease ClpX in phage biology.
  • In Vivo Gene Expression Profiling of Staphylococcus aureus during Infection Informs Design of Stemless Leukocidins LukE and -D as Detoxified Vaccine Candidates
    Andreas F. Haag, Lassi Liljeroos, Paolo Donato, Clarissa Pozzi, Tarcisio Brignoli, Matthew J. Bottomley, Fabio Bagnoli, Isabel Delany
    Microbiology Spectrum, 2023
    Vaccination is an attractive strategy for preventing bacterial infections in an age of increased antimicrobial resistance. However, vaccine development frequently suffers significant setbacks when candidate antigens that show promising results in in vitro experimentation fail to protect from disease.
  • Multilayer Regulation of Neisseria meningitidis NHBA at Physiologically Relevant Temperatures
    Sara Borghi, Ana Antunes, Andreas F. Haag, Marco Spinsanti, Tarcisio Brignoli, Enea Ndoni, Vincenzo Scarlato, Isabel Delany
    Microorganisms, 2022
    Neisseria meningitidis colonizes the nasopharynx of humans, and pathogenic strains can disseminate into the bloodstream, causing septicemia and meningitis. NHBA is a surface-exposed lipoprotein expressed by all N. meningitidis strains in different isoforms. Diverse roles have been reported for NHBA in heparin-mediated serum resistance, biofilm formation, and adherence to host tissues. We determined that temperature controls the expression of NHBA in all strains tested, with increased levels at 30–32 °C compared to 37 °C. Higher NHBA expression at lower temperatures was measurable both at mRNA and protein levels, resulting in higher surface exposure. Detailed molecular analysis indicated that multiple molecular mechanisms are responsible for the thermoregulated NHBA expression. The comparison of mRNA steady-state levels and half-lives at 30 °C and 37 °C demonstrated an increased mRNA stability/translatability at lower temperatures. Protein stability was also impacted, resulting in higher NHBA stability at lower temperatures. Ultimately, increased NHBA expression resulted in higher susceptibility to complement-mediated killing. We propose that NHBA regulation in response to temperature downshift might be physiologically relevant during transmission and the initial step(s) of interaction within the host nasopharynx. Together these data describe the importance of NHBA both as a virulence factor and as a vaccine antigen during neisserial colonization and invasion.
  • Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis
    Rodrigo Ibarra-Chávez, Aisling Brady, John Chen, José R. Penadés, Andreas F. Haag
    Plos Genetics, 2022
    Phage-inducible chromosomal islands (PICIs) are a widespread family of highly mobile genetic elements that disseminate virulence and toxin genes among bacterial populations. Since their life cycle involves induction by helper phages, they are important players in phage evolution and ecology. PICIs can interfere with the lifecycle of their helper phages at different stages resulting frequently in reduced phage production after infection of a PICI-containing strain. Since phage defense systems have been recently shown to be beneficial for the acquisition of exogenous DNA via horizontal gene transfer, we hypothesized that PICIs could provide a similar benefit to their hosts and tested the impact of PICIs in recipient strains on host cell viability, phage propagation and transfer of genetic material. Here we report an important role for PICIs in bacterial evolution by promoting the survival of phage-mediated transductants of chromosomal or plasmid DNA. The presence of PICIs generates favorable conditions for population diversification and the inheritance of genetic material being transferred, such as antibiotic resistance and virulence genes. Our results show that by interfering with phage reproduction, PICIs can protect the bacterial population from phage attack, increasing the overall survival of the bacterial population as well as the transduced cells. Moreover, our results also demonstrate that PICIs reduce the frequency of lysogenization after temperate phage infection, creating a more genetically diverse bacterial population with increased bet-hedging opportunities to adapt to new niches. In summary, our results identify a new role for the PICIs and highlight them as important drivers of bacterial evolution.
  • Staphylococcus
    Amy C. Pickering, Andreas F. Haag, José R. Penades, J. Ross Fitzgerald
    Pathogenesis of Bacterial Infections in Animals Fifth Edition, 2022
  • Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements
    Suzanne Humphrey, Alfred Fillol-Salom, Nuria Quiles-Puchalt, Rodrigo Ibarra-Chávez, Andreas F. Haag, John Chen, José R. Penadés
    Nature Communications, 2021
    It is commonly assumed that the horizontal transfer of most bacterial chromosomal genes is limited, in contrast to the frequent transfer observed for typical mobile genetic elements. However, this view has been recently challenged by the discovery of lateral transduction in Staphylococcus aureus, where temperate phages can drive the transfer of large chromosomal regions at extremely high frequencies. Here, we analyse previously published as well as new datasets to compare horizontal gene transfer rates mediated by different mechanisms in S. aureus and Salmonella enterica. We find that the horizontal transfer of core chromosomal genes via lateral transduction can be more efficient than the transfer of classical mobile genetic elements via conjugation or generalized transduction. These results raise questions about our definition of mobile genetic elements, and the potential roles played by lateral transduction in bacterial evolution.
  • A regulatory cascade controls Staphylococcus aureus pathogenicity island activation
    Andreas F. Haag, Magdalena Podkowik, Rodrigo Ibarra-Chávez, Francisca Gallego del Sol, Geeta Ram, John Chen, Alberto Marina, Richard P. Novick, José R. Penadés
    Nature Microbiology, 2021
  • Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen
    Gonzalo Yebra, Andreas F. Haag, Maan M. Neamah, Bryan A. Wee, Emily J. Richardson, Pilar Horcajo, Sander Granneman, María Ángeles Tormo-Más, Ricardo de la Fuente, J. Ross Fitzgerald, José R. Penadés
    Plos Pathogens, 2021
    The emergence of new pathogens is a major threat to public and veterinary health. Changes in bacterial habitat such as a switch in host or disease tropism are typically accompanied by genetic diversification.Staphylococcus aureusis a multi-host bacterial species associated with human and livestock infections. A microaerophilic subspecies,Staphylococcus aureussubsp.anaerobius, is responsible for Morel’s disease, a lymphadenitis restricted to sheep and goats. However, the evolutionary history ofS.aureussubsp.anaerobiusand its relatedness toS.aureusare unknown. Population genomic analyses of clinicalS.aureussubsp.anaerobiusisolates revealed a highly conserved clone that descended from aS.aureusprogenitor about 1000 years ago before differentiating into distinct lineages that contain African and European isolates.S.aureussubsp.anaerobiushas undergone limited clonal expansion, with a restricted population size, and an evolutionary rate 10-fold slower thanS.aureus. The transition to its current restricted ecological niche involved acquisition of a pathogenicity island encoding a ruminant host-specific effector of abscess formation, large chromosomal re-arrangements, and the accumulation of at least 205 pseudogenes, resulting in a highly fastidious metabolism. Importantly, expansion of ~87 insertion sequences (IS) located largely in intergenic regions provided distinct mechanisms for the control of expression of flanking genes, including a novel mechanism associated with IS-mediated anti-anti-sense decoupling of ancestral gene repression. Our findings reveal the remarkable evolutionary trajectory of a host-restricted bacterial pathogen that resulted from extensive remodelling of theS.aureusgenome through an array of diverse mechanisms in parallel.
  • Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus
    B. Rapun-Araiz, A. F. Haag, V. De Cesare, C. Gil, P. Dorado-Morales, J. R. Penades, I. Lasa
    Msystems, 2020
    Bacteria are able to sense environmental conditions and respond accordingly. Their sensorial system relies on pairs of sensory and regulatory proteins, known as two-component systems (TCSs). The majority of bacteria contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. Traditionally, the function of each TCS has been determined by analyzing the changes in gene expression caused by the absence of individual TCSs. Here, we used a bacterial strain deprived of the complete TC sensorial system to introduce, one by one, the active form of every TCS. This gain-of-function strategy allowed us to identify the changes in gene expression conferred by each TCS without interference of other members of the family.
  • The impact of two-component sensorial network in staphylococcal speciation
    Beatriz Rapun-Araiz, Andreas F Haag, Cristina Solano, Iñigo Lasa
    Current Opinion in Microbiology, 2020
  • Rebooting Synthetic Phage-Inducible Chromosomal Islands: One Method to Forge Them All
    Rodrigo Ibarra-Chávez, Andreas F. Haag, Pedro Dorado-Morales, Iñigo Lasa, José R. Penadés
    Biodesign Research, 2020
  • Terminal bacteroid differentiation in the Medicago–rhizobium interaction – a tug of war between plant and bacteria
    Andreas F. Haag, Peter Mergaert
    Model Legume Medicago Truncatula, 2019
  • The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence
    Kate L. Seib, Andreas F. Haag, Francesca Oriente, Laura Fantappiè, Sara Borghi, Evgeny A. Semchenko, Benjamin L. Schulz, Francesca Ferlicca, Anna Rita Taddei, Marzia M. Giuliani, Mariagrazia Pizza, Isabel Delany
    FASEB Journal, 2019
  • Staphylococcus aureus in animals
    Andreas F. Haag, J. Ross Fitzgerald, José R. Penadés
    Microbiology Spectrum, 2019
  • Staphylococcus aureus in animals
    Andreas F. Haag, J. Ross Fitzgerald, José R. Penadés
    Gram Positive Pathogens, 2019
  • Absence of protein a expression is associated with higher capsule production in staphylococcal isolates
    Tarcisio Brignoli, Andrea G. O. Manetti, Roberto Rosini, Andreas F. Haag, Vincenzo Scarlato, Fabio Bagnoli, Isabel Delany
    Frontiers in Microbiology, 2019
  • Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus
    Maan M. Neamah, Ignacio Mir-Sanchis, María López-Sanz, Sonia Acosta, Ignacio Baquedano, Andreas F. Haag, Alberto Marina, Silvia Ayora, José R. Penadés
    Nucleic Acids Research, 2017
  • The role of two-component signal transduction systems in Staphylococcus aureus virulence regulation
    Andreas F. Haag, Fabio Bagnoli
    Current Topics in Microbiology and Immunology, 2017
  • In vivo analysis of Staphylococcus aureus-infected mice reveals differential temporal and spatial expression patterns of fhuD2
    Marta Bacconi, Andreas F. Haag, Emiliano Chiarot, Paolo Donato, Fabio Bagnoli, Isabel Delany, Giuliano Bensi
    Infection and Immunity, 2017
  • Adaptations of cold- and pressure-loving bacteria to the deep-sea environment: Cell envelope and flagella
    Kamila K. Myka, David J. Allcock, Emiley A. Eloe-Fadrosh, Theodora Tryfona, Andreas F. Haag, Federico M. Lauro, Douglas H. Bartlett, Gail P. Ferguson
    Microbial Ecology of Extreme Environments, 2017
  • Exploring host-pathogen interactions through genome wide protein microarray analysis
    Luigi Scietti, Katia Sampieri, Irene Pinzuti, Erika Bartolini, Barbara Benucci, Alessia Liguori, Andreas F. Haag, Paola Lo Surdo, Werner Pansegrau, Vincenzo Nardi-Dei, Laura Santini, Seguinde Arora, Xavier Leber, Simonetta Rindi, Silvana Savino, Paolo Costantino, Domenico Maione, Marcello Merola, Pietro Speziale, Matthew J. Bottomley, Fabio Bagnoli, Vega Masignani, Mariagrazia Pizza, Meike Scharenberg, Jean-Marc Schlaeppi, Mikkel Nissum, Sabrina Liberatori
    Scientific Reports, 2016
  • A stable luciferase reporter plasmid for in vivo imaging in murine models of Staphylococcus aureus infections
    Marta Bacconi, Andreas F. Haag, Antonina Torre, Andrea Castagnetti, Emiliano Chiarot, Isabel Delany, Giuliano Bensi
    Applied Microbiology and Biotechnology, 2016
  • Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA
    Alessia Liguori, Enrico Malito, Paola Lo Surdo, Luca Fagnocchi, Francesca Cantini, Andreas F. Haag, Sébastien Brier, Mariagrazia Pizza, Isabel Delany, Matthew J. Bottomley
    Plos Pathogens, 2016
  • Molecular insights into bacteroid development during Rhizobium-legume symbiosis
    Andreas F. Haag, Markus F. F. Arnold, Kamila K. Myka, Bernhard Kerscher, Sergio Dall'Angelo, Matteo Zanda, Peter Mergaert, Gail P. Ferguson
    FEMS Microbiology Reviews, 2013
  • Partial complementation of Sinorhizobium meliloti baca mutant phenotypes by the Mycobacterium tuberculosis BacA protein
    M. F. F. Arnold, A. F. Haag, S. Capewell, H. I. Boshoff, E. K. James, R. McDonald, I. Mair, A. M. Mitchell, B. Kerscher, T. J. Mitchell, P. Mergaert, C. E. Barry, M. Scocchi, M. Zanda, D. J. Campopiano, G. P. Ferguson
    Journal of Bacteriology, 2013
  • Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide
    Andreas F. Haag, Bernhard Kerscher, Sergio Dall'Angelo, Monica Sani, Renato Longhi, Mikhail Baloban, Heather M. Wilson, Peter Mergaert, Matteo Zanda, Gail P. Ferguson
    Journal of Biological Chemistry, 2012
  • Protection of sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis
    Andreas F. Haag, Mikhail Baloban, Monica Sani, Bernhard Kerscher, Olivier Pierre, Attila Farkas, Renato Longhi, Eric Boncompagni, Didier Hérouart, Sergio Dall’Angelo, Eva Kondorosi, Matteo Zanda, Peter Mergaert, Gail P. Ferguson
    Plos Biology, 2011
  • Biochemical characterization of Sinorhizobium meliloti mutants reveals gene products involved in the biosynthesis of the unusual lipid A very long-chain fatty acid
    Andreas F. Haag, Silvia Wehmeier, Artur Muszyński, Bernhard Kerscher, Vivien Fletcher, Susan H. Berry, Georgina L. Hold, Russell W. Carlson, Gail P. Ferguson
    Journal of Biological Chemistry, 2011
  • Importance of lipopolysaccharide and cyclic β-1,2-glucans in Brucella-mammalian infections
    Andreas F. Haag, Kamila K. Myka, Markus F. F. Arnold, Paola Caro-Hernández, Gail P. Ferguson
    International Journal of Microbiology, 2010
  • BacA is essential for bacteroid development in nodules of galegoid, but not phaseoloid, legumes
    Ramakrishnan Karunakaran, Andreas F. Haag, Alison K. East, Vinoy K. Ramachandran, Jurgen Prell, Euan K. James, Marco Scocchi, Gail P. Ferguson, Philip S. Poole
    Journal of Bacteriology, 2010
  • The Sinorhizobium meliloti LpxXL and AcpXL proteins play important roles in bacteroid development within alfalfa
    Andreas F. Haag, Silvia Wehmeier, Sebastian Beck, Victoria L. Marlow, Vivien Fletcher, Euan K. James, Gail P. Ferguson
    Journal of Bacteriology, 2009
  • Positive-selection vector for direct protein expression
    Andreas F. Haag, Christian Ostermeier
    Biotechniques, 2009
  • Essential role for the BacA protein in the uptake of a truncated eukaryotic peptide in Sinorhizobium meliloti
    Victoria L. Marlow, Andreas F. Haag, Hajime Kobayashi, Vivien Fletcher, Marco Scocchi, Graham C. Walker, Gail P. Ferguson
    Journal of Bacteriology, 2009

RECENT SCHOLAR PUBLICATIONS

  • Draft genome sequence of a non-tuberculous Mycobacterium strain isolated from a clinical urine sample
    JER Ramos, PR Johnston, RJH Hammond, MTG Holden, DJ Sloan, ...
    Access Microbiology 8 (1), 001110. v3 , 2026
    2026
    Citations: 1
  • Draft Genome Sequence of a non-tuberculous Mycobacterium Strain Isolated from a Clinical Urine Sample.
    RR JE, PR Johnston, RJH Hammond, MTG Holden, DJ Sloan, AF Haag
    2025
  • Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
    M Podkowik, AI Perault, G Putzel, A Pountain, J Kim, AL DuMont, ...
    Elife 12, RP89098 , 2024
    2024
    Citations: 46
  • The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus
    MA Thabet, JR Penadés, AF Haag
    Nature Communications 14 (1), 6599 , 2023
    2023
    Citations: 11
  • In Vivo Gene Expression Profiling of Staphylococcus aureus during Infection Informs Design of Stemless Leukocidins LukE and -D as Detoxified Vaccine Candidates
    AF Haag, L Liljeroos, P Donato, C Pozzi, T Brignoli, MJ Bottomley, ...
    Microbiology spectrum 11 (1), e02574-22 , 2023
    2023
    Citations: 6
  • S. aureus antigens and compositions thereof
    F Bagnoli, A Haag, L LILJEROOS
    US Patent App. 17/783,725 , 2023
    2023
  • S. aureus antigens and compositions thereof
    F Bagnoli, A Haag, L Liljeroos
    2023
  • Staphylococcus
    AC Pickering, AF Haag, JR Penades, JR Fitzgerald
    Pathogenesis of bacterial infections in animals, 543-564 , 2022
    2022
    Citations: 6
  • The ClpX protease is essential for removing the CI master repressor and completing prophage induction in Staphylococcus aureus
    MA Thabet, JR Penadés, AF Haag
    bioRxiv, 2022.09. 18.507959 , 2022
    2022
    Citations: 2
  • Regulatory cascade in Staphylococcus aureus pathogenicity island activation
    AF Haag, M Podkowik, R Ibarra-Chávez, FG del Sol, G Ram, J Chen, ...
    Microbiology Society Annual Conference 2021 , 2022
    2022
  • Systematic Reconstruction of the Complete Two-Component Sensorial Network in Staphylococcus aureus
    A Haag, B Rapun-Araiz, VD Cesare, P Dorado-Morales, J Penadés, ...
    Access Microbiology 4 (5), po0644 , 2022
    2022
  • Regulatory cascade in SaPI activation
    A Haag, M Podkowik, R Ibarra-Chávez, FG del Sol, G Ram, J Chen, ...
    Access Microbiology 4 (5), po0626 , 2022
    2022
  • Multilayer Regulation of Neisseria meningitidis NHBA at Physiologically Relevant Temperatures
    S Borghi, A Antunes, AF Haag, M Spinsanti, T Brignoli, E Ndoni, ...
    Microorganisms 10 (4), 834 , 2022
    2022
    Citations: 5
  • Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis
    R Ibarra-Chavez, A Brady, J Chen, JR Penades, AF Haag
    PLoS Genetics 18 (3), e1010146 , 2022
    2022
    Citations: 26
  • Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements
    S Humphrey, A Fillol-Salom, N Quiles-Puchalt, R Ibarra-Chávez, AF Haag, ...
    Nature communications 12 (1), 6509 , 2021
    2021
    Citations: 113
  • A regulatory cascade controls Staphylococcus aureus pathogenicity island activation
    AF Haag, M Podkowik, R Ibarra-Chávez, F Gallego del Sol, G Ram, ...
    Nature microbiology 6 (10), 1300-1308 , 2021
    2021
    Citations: 40
  • Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen
    G Yebra, AF Haag, MM Neamah, BA Wee, EJ Richardson, P Horcajo, ...
    PLoS Pathogens 17 (5), e1009606 , 2021
    2021
    Citations: 19
  • Massive genome decay and insertion sequence expansion drive the evolution of a novel host-restricted bacterial pathogen
    G Yebra, AF Haag, MM Neamah, BA Wee, EJ Richardson, P Horcajo, ...
    bioRxiv, 2020.10. 13.331058 , 2020
    2020
  • Systematic reconstruction of the complete two-component sensorial network in Staphylococcus aureus
    B Rapun-Araiz, AF Haag, V De Cesare, C Gil, P Dorado-Morales, ...
    Msystems 5 (4), 10.1128/msystems. 00511-20 , 2020
    2020
    Citations: 57
  • The impact of two-component sensorial network in staphylococcal speciation
    B Rapun-Araiz, AF Haag, C Solano, I Lasa
    2020
    Citations: 33

MOST CITED SCHOLAR PUBLICATIONS

  • Staphylococcus aureus in Animals
    AF Haag, JR Fitzgerald, JR Penadés
    Microbiology spectrum 7 (3), 10.1128/microbiolspec. gpp3-0060-2019 , 2019
    2019
    Citations: 406
  • Protection of Sinorhizobium against Host Cysteine-Rich Antimicrobial Peptides Is Critical for Symbiosis
    AF Haag, M Baloban, M Sani, B Kerscher, O Pierre, A Farkas, R Longhi, ...
    PLoS biology 9 (10), e1001169 , 2011
    2011
    Citations: 235
  • Molecular insights into bacteroid development during Rhizobium– legume symbiosis
    AF Haag, MFF Arnold, KK Myka, B Kerscher, S Dall'Angelo, M Zanda, ...
    FEMS microbiology reviews 37 (3), 364-383 , 2013
    2013
    Citations: 213
  • The Role of Two-Component Signal Transduction Systems in Staphylococcus aureus Virulence Regulation
    AF Haag, F Bagnoli
    Staphylococcus aureus: Microbiology, Pathology, Immunology, Therapy and … , 2016
    2016
    Citations: 142
  • Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide
    AF Haag, B Kerscher, S Dall'Angelo, M Sani, R Longhi, M Baloban, ...
    Journal of Biological Chemistry 287 (14), 10791-10798 , 2012
    2012
    Citations: 115
  • Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements
    S Humphrey, A Fillol-Salom, N Quiles-Puchalt, R Ibarra-Chávez, AF Haag, ...
    Nature communications 12 (1), 6509 , 2021
    2021
    Citations: 113
  • Importance of Lipopolysaccharide and Cyclic β ‐1,2‐Glucans in Brucella ‐Mammalian Infections
    AF Haag, KK Myka, MFF Arnold, P Caro-Hernández, GP Ferguson
    International journal of microbiology 2010 (1), 124509 , 2010
    2010
    Citations: 106
  • Essential Role for the BacA Protein in the Uptake of a Truncated Eukaryotic Peptide in Sinorhizobium meliloti
    VL Marlow, AF Haag, H Kobayashi, V Fletcher, M Scocchi, GC Walker, ...
    Journal of bacteriology 191 (5), 1519-1527 , 2009
    2009
    Citations: 98
  • BacA is essential for bacteroid development in nodules of galegoid, but not phaseoloid, legumes
    R Karunakaran, AF Haag, AK East, VK Ramachandran, J Prell, EK James, ...
    Journal of bacteriology 192 (11), 2920-2928 , 2010
    2010
    Citations: 94
  • Systematic reconstruction of the complete two-component sensorial network in Staphylococcus aureus
    B Rapun-Araiz, AF Haag, V De Cesare, C Gil, P Dorado-Morales, ...
    Msystems 5 (4), 10.1128/msystems. 00511-20 , 2020
    2020
    Citations: 57
  • The Sinorhizobium meliloti LpxXL and AcpXL Proteins Play Important Roles in Bacteroid Development within Alfalfa
    AF Haag, S Wehmeier, S Beck, VL Marlow, V Fletcher, EK James, ...
    Journal of Bacteriology 191 (14), 4681-4686 , 2009
    2009
    Citations: 51
  • Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
    M Podkowik, AI Perault, G Putzel, A Pountain, J Kim, AL DuMont, ...
    Elife 12, RP89098 , 2024
    2024
    Citations: 46
  • A regulatory cascade controls Staphylococcus aureus pathogenicity island activation
    AF Haag, M Podkowik, R Ibarra-Chávez, F Gallego del Sol, G Ram, ...
    Nature microbiology 6 (10), 1300-1308 , 2021
    2021
    Citations: 40
  • The impact of two-component sensorial network in staphylococcal speciation
    B Rapun-Araiz, AF Haag, C Solano, I Lasa
    2020
    Citations: 33
  • Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein
    MFF Arnold, AF Haag, S Capewell, HI Boshoff, EK James, R McDonald, ...
    Journal of bacteriology 195 (2), 389-398 , 2013
    2013
    Citations: 33
  • Exploring host-pathogen interactions through genome wide protein microarray analysis
    L Scietti, K Sampieri, I Pinzuti, E Bartolini, B Benucci, A Liguori, AF Haag, ...
    Scientific reports 6 (1), 27996 , 2016
    2016
    Citations: 31
  • Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus
    MM Neamah, I Mir-Sanchis, M López-Sanz, S Acosta, I Baquedano, ...
    Nucleic Acids Research 45 (11), 6507-6519 , 2017
    2017
    Citations: 29
  • Molecular basis of ligand-dependent regulation of NadR, the transcriptional repressor of meningococcal virulence factor NadA
    A Liguori, E Malito, P Lo Surdo, L Fagnocchi, F Cantini, AF Haag, S Brier, ...
    PLoS pathogens 12 (4), e1005557 , 2016
    2016
    Citations: 29
  • Biochemical characterization of Sinorhizobium meliloti mutants reveals gene products involved in the biosynthesis of the unusual lipid A very long-chain fatty acid
    AF Haag, S Wehmeier, A Muszyński, B Kerscher, V Fletcher, SH Berry, ...
    Journal of Biological Chemistry 286 (20), 17455-17466 , 2011
    2011
    Citations: 29
  • Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis
    R Ibarra-Chavez, A Brady, J Chen, JR Penades, AF Haag
    PLoS Genetics 18 (3), e1010146 , 2022
    2022
    Citations: 26