I am Dr. AVULA BALAKRISHNA from India, an experienced researcher in Synthetic organic and Medicinal , Iam HOD of Chemistry@RGMCET, Nandyal. India. I pursued my postdoctoral research in Department of Chemistry, University of Delaware, USA from February 2015 till February February 2016 and University of Coimbra, Portugal since September 2011 to September 2014. My thesis is entitled “Synthesis, Spectral Characterization and Bioactivity of Some Novel Organophosphorus Compounds” JULY 2010, Sri Venkateswara University, Tirupati, India. I have expertize in Organic Synthesis, in particular those aspects related to Heterocyclic Chemistry Synthesis of Porphyrins and Metalloporphyrins which may be used in Medicinal Chemistry for photodynamic therapy, Biomedicine and Environmental Technologies. Synthesis of Phosphorus bio-active heterocycles as Potential Pharmaceuticals in Medicine.
EDUCATION
M.., Ph.D
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Chemistry, Analytical Chemistry, General Chemistry
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Scopus Publications
Scopus Publications
Evaluation of Geometrical, Vibrational, Electronic and Other Molecular Parameters of Two Vinyl Sulfone Derivatives Using Experimental Spectroscopic and Computational Density Functional Theory Analyses K. Suresh, K. Srishailam, S. Radhika, J. Sunil, A. Balakrishna, G. Ramana Rao Polycyclic Aromatic Compounds, 2026 The goal of this article is to characterize 2-(phenylsulfonyl)vinylbenzene(PVB) and 1-chloro-4-(phenylsulfonyl)vinylbenzene(CVB), using experimental spectroscopic techniques (FT-IR, FT Raman, UV-Vis) and computational tools (DFT, TD-DFT, Gauss View, MOLVIB, NBO software ORIGIN). Density functional theory formalism at DFT/B3LYP/6-311++G(d,p) level was employed to determine barrier hights around (C1-S12), (S12-C15) and (C17-C19) bonds, ground state geometry, general valence force field, harmonic vibrational fundamentals, and vital molecular electronic parameters (FMO,NLO, NBO, MESP), whereas, in combination with MOLVIB, it provided scaled values for force field and vibrational frequencies, along with eigenvectors, potential energy distribution (PED), infrared and Raman intensities, and simulated vibrational spectra, while its time dependent variant computed absorption maxima (λmax) and oscillator strengths and simulated UV-Vis spectra for electron transitions in various solvents for the target molecules. Experimental and corresponding theoretical parameters for structure, and vibrational wavenumbers, and measured and simulated spectra agreed very well. Experimental and scaled vibrational frequencies agreed with rms error 9.0 and 5.4 cm−1 for PVB and CVB, respectively. PED and eigenvectors helped in the assignment of all the eighty-one fundamentals of each of the two molecules unambiguously. Comparative study made for frontier molecular orbital (FMO) parameters revealed that PVB is less reactive and more stable, in comparison with CVB, with energy gap (ΔE) values 3.60 and 3.23 eV, for PVB and CVB, respectively. Nonlinear optical (NLO) investigation ascertained their utility for NLO applications. Natural bond orbital (NBO) analysis made it clear that the highest contribution of stabilization energy comes from (C3–C4)π→(C1–C2)π* interaction which were 23.40 and 23.50 kcal/mol for PVB and CVB, respectively. MESP mapping confirmed that sulfone moiety was an electrophilic group and identified its oxygen atoms as sites for an electrophilic attack. The most significant aspect of these investigations was, that we tried to explain major changes observed for vibrational and electronic parameters of CVB in terms of the increased mass, and inductive and resonance effects of the chlorine atom, in comparison with PVB, to the extent possible.
Method development and validation of a reversed phase HPLC method for determination of Anastrazole and Temozolomide in pharmaceutical dosage form N. M. D. Akram, N. Madana Gopal, A. Balakrishna, N. Bakthavatchala Reddy Aip Conference Proceedings, 2020 . A new simple assay method has been developed and validated for the determination of Anastrazole and Temozolomide using reverse-phase high performance liquid chromatography in their pharmaceutical dosage form. The chromatographic separation was performed on an Inertsil ODS (4.6 x 150mm, 5µm) using mobile phase phosphate buffer pH 3.0 and methanol of 30:70% v/v at a flow rate of 0.8 mL/min. Analytes were detected at 260 nm. The method was found to be linear in the concentration range of 1-5 μg/mL for both medicaments with the coefficient value (R2) of >0.999. The accuracy was measured via recovery studies and found to be acceptable and the percentage recoveries were found in the range of 98.81-100.72 and 99.29-100.70%. The proposed method was successfully validated and applied for the quantitative estimation of these drugs in both bulk and tablet dosage forms.
A new validated RP-HPLC method for the determination of Tinidazole and Roxithromycin in its bulk and pharmaceutical dosage forms N. M. D. Akram, N. Madana Gopal, A. Balakrishna, N. Bakthavatchala Reddy, Grigory V. Zyryanov Aip Conference Proceedings, 2020 . To develop and validate a novel reverse phase high performance liquid chromatography determination of Tinidazole and Roxithromycin in its Bulk and Pharmaceutical Dosage Forms. Examination of simultaneous determination is centered around the advancement of novel RPHPLC systematic technique for the assurance of medication substance in strong oral dose shapes and their approval. Optimized chromatographic condition was established for the estimation of Tinidazole and Roxithromycin by using Agilent C 18 (4.6 X 250mm, 5 µm) column, sodium acetate buffer (P H 3) and Methanol (30:70% v/v) as mobile phase at a flow rate of 1.0 ml/min sustain an ambient temperature. The total analysis time was 10 minutes and retention of Tinidazole and Roxithromycin was found to be 2.352 and 5.941 min with an injection volume of 20 µl. The system suitability parameters proved for optimized chromatographic conditions for Tinidazole and Roxithromycin
Synthesis of α-aminophosphonates by the Kabachnik-Fields reaction G. Sravya, A. Balakrishna, Grigory V. Zyryanov, G. Mohan, C. Suresh Reddy, N. Bakthavatchala Reddy Phosphorus Sulfur and Silicon and the Related Elements, 2020 The review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α-aminophosphonates via Kabachnik-Fields reaction by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These α-aminophosphonates exhibited promising antioxidant, antimicrobial and anticancer activity. Some recent developments on the synthesis of biologically active α-aminophosphonates in the presence of various catalysts, in catalytic solvent medium, in catalyst-free solvent medium, under solvent-free conditions, and reactions in solution are discussed. Miscellaneous reactions are also included. Graphical Abstract
A meglumine catalyst–based synthesis, molecular docking, and antioxidant studies of dihydropyrano[3, 2-b]chromenedione derivatives G. Sravya, G. Suresh, Grigory V. Zyryanov, A. Balakrishna, K. Madhu Kumar Reddy, C. Suresh Reddy, C. Venkataramaiah, W. Rajendra, N. Bakthavatchala Reddy Journal of Heterocyclic Chemistry, 2020 A simple method was employed for the synthesis of dihydropyrano[3, 2‐b]chromenedione derivatives (4a‐o) in high yields by condensation of 5, 5‐dimethylcyclohexane‐1, 3‐dione(1), different aromatic aldehydes (2a‐o), and 5‐hydroxy‐2‐(hydroxymethyl)‐4H‐pyran‐4‐one(3), using meglumine as a stable and reusable catalyst. Meglumine, an amino sugar, was employed as an environmentally benign catalyst, due to its splendid properties such as being inexpensive, recyclable, and biodegradable. The accomplished protocol employs low catalyst loading and easy work‐up for the synthesis of 5‐hydroxy‐2‐(hydroxymethyl)‐4H‐pyran‐4‐one derivatives. A great asset is that without any significant loss, the catalyst could be recovered and reused for extended synthetic steps. This offer huge advantage to overcome recyclability issues. Our synthesized compounds were analyzed by IR, 1H, 13C NMR, mass spectra and evaluated for their antioxidant properties by 1, 1‐diphenyl‐2‐picryl hydrazyl radical (DPPH), hydrogen peroxide(H2O2), and nitric oxide (NO) scavenging methods. The correlation in exhibition of antioxidant activity was effective at all doses. The binding interactions and molecular docking studies for entitled compounds were studied against 3MNG protein; 4k exhibited marked binding affinity with excellent docking score of −7.6 Kcal/mol and emerged as a lead compound.
Design and Synthesis of Some New Benzimidazole Containing Pyrazoles and Pyrazolyl Thiazoles as Potential Antimicrobial Agents Nemallapudi Bakthavatchala Reddy, Grigory V. Zyryanov, Guda Mallikarjuna Reddy, Avula Balakrishna, Adivireddy Padmaja, Venkatapuram Padmavathi, Cirandur Suresh Reddy, Jarem Raul Garcia, Gundala Sravya Journal of Heterocyclic Chemistry, 2019 A new class of bis heterocycles‐benzimidazolyl pyrazoles were prepared from the Michael acceptor ( E )‐3‐(1 H ‐benzimidazol‐2‐yl)‐1‐aryl‐prop‐2‐en‐1‐one. The thiamide group was exploited to develop thiazole ring on treatment with p ‐fluorophenacyl bromide to get tris heterocycles. All the lead compounds were tested for antimicrobial activity. The compound 7d having nitro substituent on the aromatic ring showed greater antimicrobial activity particularly against Pseudomonas aeruginosa and P enicillium chrysogenum .
Synthesis and bioassay of styryl sulfonylmethyl oxazolyl tethered morpholines and thiomorpholines G. Sravya, N. Bakthavatchala Reddy, A. Balakrishna, Grigory V. Zyryanov Aip Conference Proceedings, 2019 A new class of mono and bis heterocycles-4-(chloromethyl)((styrylsulfonyl)methyl) oxazoles and 4-(chloromethyl)((styrylsulfonyl)methyl)oxazolyl morpholines/thiomorpholines were prepared from the synthetic intermediate Z-styrylsulfonylaceticacid adopting simple and well versed synthetic methodologies and were studied for their respective antimicrobial activity. All the entitled compounds were characterized by IR, 1 H, 13 C NMR, mass spectra.
Synthesis and antimicrobial activity of 2,10-dichloro-6-substituted amino acid ester- 12H-dibenzo [d,g] [1,3,2] dioxaphosphocin-6-oxides Bulgarian Chemical Communications, 2009
One-step synthesis and bioassay of N-phosphoramidophosphonates Mudumala Veera Narayana Reddy, Avula Balakrishna, Mungara Anil Kumar, Gangireddygari Chandra Sekhar Reddy, Arigela Uma Ravi Sankar, Cirandur Suresh Reddy, Tirupati Murali Krishna Chemical and Pharmaceutical Bulletin, 2009
Synthesis, characterization and bio-activity of some new α-aminophosphonates Bulletin of the Chemical Society of Ethiopia, 2009