Maria Stella Figueiredo

Scopus Publications

Hematological ratios and cytokine profiles in heterozygous beta-thalassemia
Ana Carolina Marques Ciceri, Laura Eduarda de Oliveira, Ana Luísa Richter, José Antonio Mainardi de Carvalho, Maylla Rodrigues Lucena, Guilherme Wataru Gomes, Maria Stella Figueiredo, Magnun Nueldo Nunes dos Santos, Vera Lúcia Nascimento Blaia-D'Avila, Rodolfo Delfini Cançado, Elvira Maria Guerra-Shinohara, Clóvis Paniz
Hematology Transfusion and Cell Therapy, 2025
INTRODUCTION: β-Thalassemia is defined by a reduced or complete absence of β-globin chain synthesis in hemoglobin, leading to hemolytic anemia. Heterozygous β-thalassemia, also known as β-thalassemia trait (hBTh), the mildest form of this anemia, typically does not cause symptoms in carriers. However, it may lead to changes in the immune system, including an increase in total leukocyte, neutrophil, and lymphocyte counts. OBJECTIVE: This study aimed to evaluate various immune and inflammation markers, including neutrophil/lymphocyte, derived neutrophil/lymphocyte, lymphocyte/monocyte, platelet/lymphocyte, neutrophil/platelet ratios, systemic immune-inflammation index, systemic inflammation response index, neutrophil/natural killer cell ratio (NNKR), and inflammatory cytokines in β-thalassemia trait carriers. METHOD: A retrospective observational study was conducted, including 50 β-thalassemia trait individuals and 100 healthy controls. RESULTS: Leukocyte, neutrophil and reticulocyte counts, and interleukin 6 levels were higher in carriers compared to controls. Notably, the β-thalassemia trait group had increased neutrophil/platelet, neutrophil/lymphocyte and derived neutrophil/lymphocyte ratios, and the systemic immune-inflammation and systemic inflammation response indexes were higher compared to the controls. CONCLUSIONS: β-thalassemia trait shows a more pronounced inflammatory profile as indicated by hematological ratios. These ratios, therefore are potentially cost-effective and easily applicable markers for monitoring patients with the β-thalassemia trait.
Health-care transition services for sickle cell disease in Brazil
Jane S Hankins, Clarisse Lobo, Josefina A P Braga, Tarun Aurora, Kelly Pimenta, Maria Stella Figueiredo, Ana A Baumann
Lancet Haematology, 2024
Patient Blood Management in Cardiovascular Surgery
Isabel Cristina Céspedes, Maria Stella Figueiredo, Antonio Alceu Dos Santos, Nelson A Hossne
Brazilian Journal of Cardiovascular Surgery, 2024
Patient Blood Management in
Sickle Cell Disease in Brazil: Current Management
Aderson da Silva Araújo, Ana Cristina Silva Pinto, Clarisse Lopes de Castro Lobo, Maria Stella Figueiredo, Sandra Fátima Menosi Gualandro, Sara Teresinha Olalla Saad, Rodolfo Delfini Cançado
Hemoglobin, 2024
Sickle cell disease (SCD) comprises inherited red blood cell disorders due to a mutation in the β-globin gene (c20A > T, pGlu6Val) and is characterized by the presence of abnormal hemoglobin, hemoglobin S, hemolysis, and vaso-occlusion. This mutation, either in a homozygous configuration or in compound states with other β-globin mutations, leads to polymerization of hemoglobin S in deoxygenated conditions, causing modifications in red blood cell shape, particularly sickling. Vaso-occlusive crisis (VOC) is the hallmark of the disease, but other severe complications may arise from repeated bouts of VOCs. SCD is considered a global health problem, and its incidence has increased in some areas of the world, particularly the Americas and Africa. Management of the disease varies according to the region of the world, mainly due to local resources and socioeconomic status. This review aimed to describe more recent data on SCD regarding available treatment options, especially in Brazil. New treatment options are expected to be available to all patients, particularly crizanlizumab, which is already approved in the country.
Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals
Karina Moura Sawada, Niele Silva de Moraes, Lara Miguel Quirino Araújo, Fernanda Martins Gazoni, Marise Lazaretti-Castro, Maysa Seabra Cendoroglo, John P. Bilezikian, Maria Stella Figueiredo, Fania Cristina dos Santos
Einstein Sao Paulo Brazil, 2024
OBJECTIVE To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals. METHODS A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis. RESULTS The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL. CONCLUSION No substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.
Patient Blood Management Program Implementation: Comprehensive Recommendations and Practical Strategies
Isabel Cristina Céspedes, Maria Stella Figueiredo, Nelson A Hossne, I. Suriano, Rita de Cássia Rodrigues, M. Barros, Manoel Antonio de Paiva, Fernanda Chohfi Atallah, Bárbara Burza Benini, Adriano Miziara Gonzalez, Fábio Veiga de Castro Sparapani, Newton de Barros, Ieda Aparecida Carneiro, Celina Mayumi Morita Sarto, Caio Sussumu de Macedo Motoyama, Leonardo Sacchi, Victor Piovezan, Simone Luna de Almeida, Laís da Silva Pereira-Rufino, S. Guizilini, I. Rocco, Nacime Salomão Mansur, J. Arakaki, Antonio Alceu Dos Santos, Carlos E Panfilio
Brazilian Journal of Cardiovascular Surgery, 2024
Introduction Blood transfusion is one of the most common medical practices worldwide. However, current scientific literature has shown that the immunomodulatory effects of blood transfusion are associated with an increased likelihood of infection, prolonged hospitalization, and morbimortality. Also, it means high costs for healthcare systems. Methods In this context, acknowledging that blood transfusions are essentially heterologous cell transplantations, the use of therapeutic options has gained strength and is collectively known as the patient blood management (PBM) program. PBM is an approach based on three main pillars: (1) treating anemias and coagulopathies in an optimized manner, especially in the preoperative period; (2) optimizing perioperative hemostasis and the use of blood recovery systems to avoid the loss of the patient's blood; (3) anemia tolerance, with improved oxygen delivery and reduced oxygen demand, particularly in the postoperative period. Results Current scientific evidence supports the effectiveness of PBM by reducing the need for blood transfusions, decreasing associated complications, and promoting more efficient and safer blood management. Thus, PBM not only improves clinical outcomes for patients but also contributes to the economic sustainability of healthcare systems. Conclusion The aim of this review was to summarize PBM strategies in a comprehensive, evidence-based approach through a systematic and structured model for PBM implementation in tertiary hospitals. The recommendations proposed herein are from researchers and experts of a high-complexity university hospital in the network of the Sistema Único de Saúde, presenting itself as a strategy that can be followed as a guideline for PBM implementation in other settings.
Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease
Clarisse Lobo, Aderson Araújo, Alexandre de Albuquerque Antunes, Ana Cristina Silva Pinto, Ariadne Carvalho Godinho, Cassia Silvestre Mariano Pires, Cinthia Cristina Matheus, Xerez de Albuquerque, Daniele Campos Fontes Neves, Fábio de Lima Moreno, Giorgio Baldanzi, Grazziella Curado Siufi, Heloisa Helena Pereira Miranda, Jane Hankins, Joice Aragão, Josefina Aparecida Pellegrini Braga, Juliana Touguinha Neves Martins, Luciana Campos Costa Machado de Souza, Maria Stella Figueiredo, Mirella Rodrigues Oliveira, Patricia Santos Resende Cardoso, Patricia Costa Alves Pinto, Patricia Gomes Moura, Rodolfo Delfini Cançado, Paulo Ivo Cortez de Araujo, Sara Olalla Saad, Sandra Regina Loggetto, Teresa Cristina Cardoso Fonseca
Hematology Transfusion and Cell Therapy, 2024
To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety.
Vertebral fractures and low lean mass in young men with sickle cell disease: Lack of association with bone mineral density and clinical characteristics
Pedro Paulo de Alcantara Pedro, Charlles Heldan de Moura Castro, Marcelo de Medeiros Pinheiro, Lucila Macedo Gonçalves, Maria Stella Figueiredo, Vera Lúcia Szejnfeld
British Journal of Haematology, 2023
Low bone mass, osteoporosis and
Factors related to the readiness of Brazilian chronic pediatric patients to transition to care in adult clinics
Fernanda Souza Angotti Carrara, Daniela Gerent Petry Piotto, Ilana Izidoro Silva, Claudio Arnaldo Len, Gleice Clemente Souza Russo, Sonia Mayumi Chiba, Vera Lucia Sdepanian, Josefina Aparecida Pellegrini Braga, Maria Stella Figueiredo, Maria Cristina Andrade, Marta Liliane de Almeida Maia, Ana Lúcia Abreu, Celia Maria Camelo Silva, Maria Teresa Terreri
Jornal De Pediatria, 2023
OBJECTIVE: Advances in medicine have increased the life expectancy of pediatric patients with chronic illnesses, and challenges with the guided transition of adolescents and young adults from pediatric clinics to adult clinics have grown. The aim of this study was to better understand readiness and factors related to this transition process in Brazil. METHOD: In this cross-sectional study of 308 patients aged from 16 to 21 years under follow-up in pediatric specialties, the degree of readiness for transition was assessed using the Transition Readiness Assessment Questionnaire (TRAQ) and its domains. Associations with demographic data, clinical data, socio-economic level, medication adherence, family functionality, and parental satisfaction with health care were evaluated. RESULTS: The median TRAQ score was 3.7 (3.2 - 4.2). Better readiness was associated with female patients, socio-economic class A-B, current active employment, higher level of education, not failing any school year, attending medical appointments alone, functional family, and a good knowledge of disease and medications. A low correlation was observed between TRAQ and age. TRAQ presented good internal consistency (alpha-Cronbach 0.86). In the multiple linear regression, TRAQ score showed a significant association with female gender, advanced age, socio-economic class A-B, better knowledge of disease and medications, and independence to attend appointments alone. CONCLUSION: TRAQ instrument can guide healthcare professionals to identify specific areas of approach, in order to support adolescents with chronic disease to set goals for their own personal development and improve their readiness to enter into the adult healthcare system. In this study, some factors were related to better TRAQ scores.
Sickle cell anemia: hierarchical cluster analysis and clinical profile in a cohort in Brazil
Valéria de Freitas Dutra, Thais Priscila Biassi, Maria Stella Figueiredo
Hematology Transfusion and Cell Therapy, 2023
INTRODUCTION: Sickle cell anemia is a monogenic disorder caused by a mutation in the β-hemoglobin gene, resulting in sickle hemoglobin that can polymerize. Presentation and clinical course have significant inter-individual variability and classifying these patients for severity is a challenge. METHODS: We applied hierarchical clusters with 10 routine laboratory tests to understand if this grouping could be associated with clinical manifestations. We included 145 adult homozygous patients (SS) at an outpatient clinic in a retrospective study. RESULTS: We found five clusters by counting those that had been differentiated by unconjugated bilirubin, reticulocytes, LDH, leukocytes, lymphocytes and monocytes. When comparing groups to clinical findings, the clusters were different only for liver abnormality. Cluster 3 had the lower median of reticulocytes, LDH, leukocytes, lymphocytes and monocytes and a higher percentage of patients under treatment. Clusters 4 and 5 had higher frequencies of liver impairment and higher medians of reticulocytes, LDH, leukocytes, lymphocytes and monocytes. Hemolysis and inflammation seemed to influence the grouping. CONCLUSION: In our study, cluster analysis showed five groups that exhibited different degrees of inflammation and hemolysis. When comparing clinical data, the result was different only for the criteria of liver abnormality.
Novel Insights into the Pathophysiology and Treatment of Sickle Cell Disease
Aderson da Silva Araújo, Ana Cristina Silva Pinto, Clarisse Lopes de Castro Lobo, Maria Stella Figueiredo, Sandra Fátima Menosi Gualandro, Sara Teresinha Olalla Saad, Rodolfo Delfini Cancado
Hemoglobin, 2023
Zinc in sickle cell disease: A narrative review
Carolinne Thaisa de Oliveira Fernandes Miranda, Karina Marques Vermeulen-Serpa, Ana Carolina Cabañas Pedro, José Brandão-Neto, Sancha Helena de Lima Vale, Maria Stella Figueiredo
Journal of Trace Elements in Medicine and Biology, 2022
Genetic contribution and functional impairment of inflammasome in sickle cell disease
Valéria de Freitas Dutra, Vinícius Nunes Cordeiro Leal, Fernanda Pereira Fernandes, Cláudia Regina Lustosa Souza, Maria Stella Figueiredo, Alessandra Pontillo
Cytokine, 2022
miRNA profile and disease severity in patients with sickle cell anemia
Thaís Priscila Biassi, Elvira Maria Guerra-Shinohara, Patrícia Natália Silva Moretti, Valeria de Freitas Dutra, Ana Carolina Cabañas-Pedro, Grazielle Mecabo, Gisele Wally Braga Colleoni, Maria Stella Figueiredo
Annals of Hematology, 2022
Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria
Rodolfo D. Cançado, Aderson da Silva Araújo, Alex Freire Sandes, Celso Arrais, Clarisse Lopes de Castro Lobo, Maria Stella Figueiredo, Sandra Fátima Menosi Gualandro, Sara Teresinha Olalla Saad, Fernando Ferreira Costa
Hematology Transfusion and Cell Therapy, 2021
Serum folate and cytokines in heterozygous β-thalassemia
Clóvis Paniz, Maylla Rodrigues Lucena, Juliano Felix Bertinato, Magnun Nueldo Nunes Santos, Guilherme Wataru Gomes, Maria Stella Figueiredo, Maria de Fátima Sonati, Vera Lúcia Nascimento Blaia‐D Avila, Ralph Green, Elvira Maria Guerra‐Shinohara
International Journal of Laboratory Hematology, 2020
Rheumatoid arthritis and sickle cell disease: A potential association
Suely Roizenblatt, Ana Carolina Cabañas‐Pedro, Maria Stella Figueiredo
British Journal of Haematology, 2020
COVID-19 as a trigger of acute chest syndrome in a pregnant woman with sickle cell anemia
Caio Cesar Justino, Felipe Favorette Campanharo, Marina Nobrega Augusto, Stela Cezarino de Morais, Maria Stella Figueiredo
Hematology Transfusion and Cell Therapy, 2020
Daily supplementation with 5 mg of folic acid in Brazilian patients with hereditary spherocytosis
Clóvis Paniz, Maylla Rodrigues Lucena, Juliano Felix Bertinato, Felipe Rebello Lourenço, Bruna Cipriano A Barros, Guilherme Wataru Gomes, Maria Stella Figueiredo, Rodolfo Delfini Cançado, Vera Lúcia Nascimento Blaia-D Avila, Christine M Pfeiffer, Zia Fazili, Ralph Green, Valdemir Melechco Carvalho, Elvira Maria Guerra-Shinohara
Journal of Investigative Medicine, 2019
Male sickle cell patients, compensated transpubertal hypogonadism and normal final growth
Paulo Roberto Juliano Martins, Fernanda Bernadelli De Vito, Gláucia Aparecida Domingos Resende, José Kerbauy, Gilberto de Araújo Pereira, Helio Moraes‐Souza, Maria Stella Figueiredo, Ieda Therezinha Verreschi
Clinical Endocrinology, 2019
Molecular matching for patients with haematological diseases expressing altered RHD-RHCE genotypes
Bruno Ribeiro Cruz, Thamy Caroline de Souza Silva, Bianca de Souza Castro, Akemi Kuroda Chiba, Elyse Moritz, Josefina Pellegrini Braga, Maria Stella Figueiredo, José O Bordin
Vox Sanguinis, 2019
Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study
Rejane de Souza Macedo-Campos, Samuel Ademola Adegoke, Maria Stella Figueiredo, Josefina Aparecida Pellegrini Braga, Gisele Sampaio Silva
Journal of Stroke and Cerebrovascular Diseases, 2018
Changes in Transcranial Doppler Flow Velocities in Children with Sickle Cell Disease: The Impact of Hydroxyurea Therapy
Samuel Ademola Adegoke, Rejane de Souza Macedo-Campos, Josefina Aparecida Pellegrini Braga, Maria Stella Figueiredo, Gisele Sampaio Silva
Journal of Stroke and Cerebrovascular Diseases, 2018
Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D among Children with Sickle Cell Disease
Samuel A. Adegoke, Josefina A.P. Braga, Adekunle D. Adekile, Maria S. Figueiredo
Journal of Pediatric Hematology Oncology, 2018
The Association of Serum 25-Hydroxyvitamin D with Biomarkers of Hemolysis in Pediatric Patients with Sickle Cell Disease
Samuel A. Adegoke, Josefina A.P. Braga, Adekunle D. Adekile, Maria S. Figueiredo
Journal of Pediatric Hematology Oncology, 2018
Quality of life in adults with sickle cell disease: an integrative review of the literature
Sandra Luzinete Felix de Freitas, Maria Lucia Ivo, Maria Stella Figueiredo, Maria Auxiliadora de Souza Gerk, Cristina Brandt Nunes, Fernando de Freitas Monteiro
Revista Brasileira De Enfermagem, 2018
Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease
Samuel A Adegoke, Maria S Figueiredo, Adekunle D Adekile, Josefina A P Braga
International Health, 2017
Periodic limb movement in sleep and sickle cell disease: a neglected association?
Ana C. Cabañas‐Pedro, Suely Roizenblatt, Altay A. L. de Souza, Sérgio Tufik, Maria S. Figueiredo
British Journal of Haematology, 2017
A daily dose of 5 mg folic acid for 90 days is associated with increased serum unmetabolized folic acid and reduced natural killer cell cytotoxicity in healthy Brazilian adults
Clovis Paniz, Juliano Felix Bertinato, Maylla Rodrigues Lucena, Eduardo De Carli, Patrícia Mendonça da Silva Amorim, Guilherme Wataru Gomes, Cecília Zanin Palchetti, Maria Stella Figueiredo, Christine M Pfeiffer, Zia Fazili, Ralph Green, Elvira Maria Guerra-Shinohara
Journal of Nutrition, 2017
A phased SNP-based classification of sickle cell anemia HBB haplotypes
Elmutaz M. Shaikho, John J. Farrell, Abdulrahman Alsultan, Hatem Qutub, Amein K. Al-Ali, Maria Stella Figueiredo, David H.K. Chui, Lindsay A. Farrer, George J. Murphy, Gustavo Mostoslavsky, Paola Sebastiani, Martin H. Steinberg
BMC Genomics, 2017
Relationship between serum 25-hydroxyvitamin D and inflammatory cytokines in paediatric sickle cell disease
Samuel Ademola Adegoke, Olufemi Samuel Smith, Adekunle D. Adekile, Maria Stella Figueiredo
Cytokine, 2017
Influence of serum 25-hydroxyvitamin D on the rate of pain episodes in Nigerian children with sickle cell anaemia
Samuel Ademola Adegoke, Oyeku Akibu Oyelami, Adekunle Adekile, Maria Stella Figueiredo
Paediatrics and International Child Health, 2017
Challenges in the diagnosis of iron deficiency anemia in aged people
Niele Silva de Moraes, Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2017
A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells
Seonmi Park, Andreia Gianotti-Sommer, Francisco Javier Molina-Estevez, Kim Vanuytsel, Nick Skvir, Amy Leung, Sarah S. Rozelle, Elmutaz Mohammed Shaikho, Isabelle Weir, Zhihua Jiang, Hong-Yuan Luo, David H.K. Chui, Maria Stella Figueiredo, Abdulraham Alsultan, Amein Al-Ali, Paola Sebastiani, Martin H. Steinberg, Gustavo Mostoslavsky, George J. Murphy
Stem Cell Reports, 2017
Contraceptive practices in women with sickle-cell disease
Natália S. Carvalho, Josefina Pellegrini Braga, Márcia Barbieri, Maria R. Torloni, Maria S. Figueiredo, Cristina A. F. Guazzelli
Journal of Obstetrics and Gynaecology, 2017
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
Daniela Laranja Gomes Rodrigues, Samuel Ademola Adegoke, Rejane de Souza Macedo Campos, Josefina Aparecida Pellegrini Braga, Maria Stella Figueiredo, Gisele Sampaio Silva
Arquivos De Neuro Psiquiatria, 2017
Exercise-Induced Abnormal Increase of Systolic Pulmonary Artery Pressure in Adult Patients With Sickle Cell Anemia: An Exercise Stress Echocardiography Study
Newton Nunes de Lima‐Filho, Maria Stella Figueiredo, Perla Vicari, Rodolfo Cançado, Antonio Carlos de Camargo Carvalho, José Orlando Bordin, Orlando Campos
Echocardiography, 2016
Agents for inhibiting the adhesion of red blood cells to the endothelium in people with sickle cell disease
Adriano Morita Fernandes da Silva, Edina MK da Silva, Samuel A Adegoke, Josefina A.P Braga, Maria S Figueiredo
Cochrane Database of Systematic Reviews, 2016
Comments on: “Clinical, hematological and genetic data of a cohort of children with hemoglobin SD”
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2016
Physicians' Perception of Sickle-cell Disease Pain
Fátima Lucchesi, Maria Stella Figueiredo, Erika B. Mastandrea, James L. Levenson, Wally R. Smith, Alessandro F. Jacinto, Vanessa de A. Citero
Journal of the National Medical Association, 2016
Posterior Circulation Evaluation in Patients with Sickle Cell Anemia
Samuel Ademola Adegoke, Maria Stella Figueiredo, Perla Vicari, Henrique Carrete, Marcos Hideki Idagawa, Ayrton Roberto Massaro, Gisele Sampaio Silva
Journal of Stroke and Cerebrovascular Diseases, 2016
Interventions for preventing silent cerebral infarcts in people with sickle cell disease
Juliana SR Crespi, Josefina A.P Braga, Maria S Figueiredo, Gisele S Silva, Pedro Debieux, Edina MK da Silva
Cochrane Database of Systematic Reviews, 2016
The importance of hemoglobin A2 determination
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2015
The relationship between genotype, psychiatric symptoms and quality of life in adult patients with sickle cell disease in São Paulo, Brazil: A cross-sectional study
Érika Bergamini Mastandréa, Fátima Lucchesi, Marcela Mayumi Gomes Kitayama, Maria Stella Figueiredo, Vanessa de Albuquerque Citero
Sao Paulo Medical Journal, 2015
Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia
Bruna Spinella Pierrot-Gallo, Perla Vicari, Sandra Satiko Matsuda, Samuel Ademola Adegoke, Grazielle Mecabo, Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2015
Agents for inhibiting the adhesion of red blood cells to the endothelium in people with sickle cell disease
Adriano Morita Fernandes da Silva, Edina MK da Silva, Samuel A Adegoke, Josefina A.P Braga, Maria S Figueiredo
Cochrane Database of Systematic Reviews, 2015
Klotho gene polymorphisms and their association with sickle cell disease phenotypes
Claudia R. Lustosa Souza, Marily M. Azevedo Shimmoto, Perla Vicari, Grazielle Mecabo, Martha Mariana Arruda, Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2015
An unexpected full neurological recovery after cardiac arrest in a sickle cell anemia patient with bilateral cervical carotid artery disease
Aline Cristina Peluccio Martins, Gisele Sampaio Silva, Samuel Ademola Adegoke, Daniela Laranja Gomes Rodrigues, Josefina Aparecida Pellegrini Braga, Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2015
Lactate dehydrogenase isoenzyme 3 and hemolysis in sickle cell anemia: A possible correlation?
Grazielle Mecabo, Mihoko Yamamoto, Thais Priscila Biassi, Maria Stella Figueiredo
Blood, 2015
The compound state: Hb S/beta-thalassemia
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2015
Corrigendum to "Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifestations of sickle cell anemia" [Blood Cells Mol. Dis. 54/3(2014), 244-249]
Perla Vicari, Samuel A. Adegoke, Diego Robles Mazzotti, Rodolfo Delfini Cançado, Maria Aparecida Eiko Noguti, Maria Stella Figueiredo
Blood Cells Molecules and Diseases, 2015
Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifestations of sickle cell anemia
Perla Vicari, Samuel A. Adegoke, Diego Robles Mazzotti, Rodolfo Delfini Cançado, Maria Aparecida Eiko Nogutti, Maria Stella Figueiredo
Blood Cells Molecules and Diseases, 2015
Impaired pubertal development and testicular hormone function in males with sickle cell anemia
Paulo Roberto Juliano Martins, José Kerbauy, Helio Moraes-Souza, Gilberto de Araújo Pereira, Maria Stella Figueiredo, Ieda Therezinha Verreschi
Blood Cells Molecules and Diseases, 2015
Molecular analysis and association with clinical and laboratory manifestations in children with sickle cell anemia
Roberta Faria Camilo-Araújo, Olga Maria Silverio Amancio, Maria Stella Figueiredo, Ana Carolina Cabanãs-Pedro, Josefina Aparecida Pellegrini Braga
Revista Brasileira De Hematologia E Hemoterapia, 2014
Anemia in inflammatory bowel disease: Prevalence, differential diagnosis and association with clinical and laboratory variables
Rodrigo Andrade Alves, Sender Jankiel Miszputen, Maria Stella Figueiredo
Sao Paulo Medical Journal, 2014
Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin
Bruno Mello de Matos, Zulene Eveline Abreu Ribeiro, Ivan Balducci, Maria Stella Figueiredo, Graziella Nuernberg Back-Brito, Adolfo José da Mota, Josefina Aparecida Pellegrini Braga, Cristiane Yumi Koga-Ito
Archives of Oral Biology, 2014
Interventions for preventing silent cerebral infarcts in people with sickle cell disease
Juliana SR Crespi, Josefina A.P Braga, Maria S Figueiredo, Gisele S Silva, Pedro Debieux, Edina MK da Silva
Cochrane Database of Systematic Reviews, 2013
Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance
Ana Carolina Rodrigues Danzi Salvia, Maria Stella Figueiredo, Josefina Aparecida Pellegrini Braga, Daniel Freitas Alves Pereira, Fernanda Lourenção Brighenti, C. Y. Koga‐Ito
Journal of Oral Pathology and Medicine, 2013
Sexuality and sickle cell disease
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2013
Antioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: A randomized, double-blind, placebo-controlled trial
Martha M. Arruda, Grazielle Mecabo, Celso A. Rodrigues, Sandra S. Matsuda, Iara B. Rabelo, Maria S. Figueiredo
British Journal of Haematology, 2013
Hemoglobin sickle cell disease in Brazil
A. C. Cabanas-Pedro, J. A. P. Braga, R. F. Camilo-Araujo, A. I. M. Silva, P. Vicari, M. Figueiredo
Haematologica, 2013
Anemia and the blood donor
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2012
Priapism is associated with sleep hypoxemia in sickle cell disease
Marina Roizenblatt, Maria Stella Figueiredo, Rodolfo Delfini Cançado, Frederico Pollack-Filho, Martha Mariana de Almeida Santos Arruda, Perla Vicari, João Ricardo Sato, Sergio Tufik, Suely Roizenblatt
Journal of Urology, 2012
Analysis of polymorphisms of TNF-α, LT-α, IL-10, IL-12 and CTLA-4 in patients with warm autoimmune haemolytic anaemia
L. S. D’ABRONZO, M. M. O. BARROS, J. O. BORDIN, M. S. FIGUEIREDO
International Journal of Laboratory Hematology, 2012
Molecular analysis of β-thalassemia patients: First identification of mutations HBB:c.93-2A>G and HBB:c.114G>A in Brazil
Andrea Cristina Fernandes, Marily Maria Azevedo Shimmoto, Gilberto Koiti Furuzawa, Perla Vicari, Maria Stella Figueiredo
Hemoglobin, 2011
Hereditary hemochromatosis: Mutations in genes involved in iron homeostasis in Brazilian patients
Paulo C.J.L. Santos, Rodolfo D. Cançado, Alexandre C. Pereira, Isolmar T. Schettert, Renata A.G. Soares, Regina A. Pagliusi, Rosario D.C. Hirata, Mario H. Hirata, Ana C. Teixeira, Maria Stella Figueiredo, Carlos S. Chiattone, Jose E. Krieger, Elvira M. Guerra-Shinohara
Blood Cells Molecules and Diseases, 2011
Absence of association between TNF-α polymorphism and cerebral large-vessel abnormalities in adults with sickle cell anemia
Perla Vicari, Gisele Sampaio Silva, Maria Aparecida Eiko Nogutti, Faustino Moreira Neto, Normélia Jesus dos Santos, Ayrton Roberto Massaro, Maria Stella Figueiredo
Acta Haematologica, 2011
Brazilian guidelines for transcranial doppler in children and adolescents with sickle cell disease
Clarisse Lopes de Castro Lobo, Rodolfo Delfini Cançado, Ana Claudia Celestino Bezerra Leite, Ana Claudia Mendonça dos Anjos, Ana Cristina Silva Pinto, Andre Palma da Cunha Matta, Célia Maria Silva, Gisele Sampaio Silva, João Ricardo Friedrisch, Josefina Aparecida Pellegrini Braga, Marcos Christiano Lange, Maria Stella Figueiredo, Marília Álvares Rugani, Orlando Veloso, Patrícia Gomes Moura, Paulo Ivo Cortez, Robert Adams, Sandra Fátima Menosi Gualandro, Shirley Lopes de Castilho, Ursula Thomé, Viviane Flumignan Zetola
Revista Brasileira De Hematologia E Hemoterapia, 2011
HFE gene mutations in patients with primary iron overload: Is there a significant improvement in molecular diagnosis yield with HFE sequencing?
Paulo C.J.L. Santos, Alexandre C. Pereira, Rodolfo D. Cançado, Isolmar T. Schettert, Tiago J.P. Sobreira, Paulo S.L. Oliveira, Rosario D.C. Hirata, Mario H. Hirata, Maria Stella Figueiredo, Carlos S. Chiattone, Jose E. Krieger, Elvira M. Guerra-Shinohara
Blood Cells Molecules and Diseases, 2010
Importance of inflammation on iron homeostasis and functional iron deficiency
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2010
Differential diagnosis of iron deficiency
Perla Vicari, Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2010
Hemojuvelin and hepcidin genes sequencing in Brazilian patients with primary iron overload
Paulo Caleb Júnior de Lima Santos, Alexandre C. Pereira, Rodolfo D. Cançado, Isolmar T. Schettert, Rosario D.C. Hirata, Mario H. Hirata, Maria Stella Figueiredo, Carlos S. Chiattone, Jose E. Krieger, Elvira M. Guerra-Shinohara
Genetic Testing and Molecular Biomarkers, 2010
Duffy-negative is associated with hemolytic phenotype of sickle cell anemia
Grazielle Mecabo, Debora Yumi Hayashida, Marily Maria Azevedo-Shimmoto, Perla Vicari, Martha Mariana de Almeida Santos Arruda, José Orlando Bordin, Maria Stella Figueiredo
Clinical Immunology, 2010
Psychosocial aspects of sickle cell anemia
Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2010
Paroxysmal nocturnal hemoglobinuria: From physiopathology to treatment
Martha Mariana de Almeida Santos Arruda, Celso Arrais Rodrigues, Mihoko Yamamoto, Maria Stella Figueiredo
Revista Da Associacao Medica Brasileira, 2010
Brain magnetic resonance imaging abnormalities in adult patients with sickle cell disease correlation with transcranial doppler findings
Gisele Sampaio Silva, Perla Vicari, Maria Stella Figueiredo, Henrique Carrete, Marcos Hideki Idagawa, Ayrton Roberto Massaro
Stroke, 2009
Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-α,β on monocytes from patients with warm autoimmune hemolytic anemia
Melca M.O. Barros, Mihoko Yamamoto, Maria S. Figueiredo, Rodolfo Cançado, Elisa Y.S. Kimura, Dante M. Langhi, Carlos S. Chiattone, Jose O. Bordin
Transfusion, 2009
Multiple primary choledocholithiasis in sickle cell disease
Perla Vicari, Marco Vinicio Fanucchi Gil, Rita de Cássia Rosário Cavalheiro, Maria Stella Figueiredo
Internal Medicine, 2008
Bone mineral density in thalassemic children: A Brazilian experience
Revista Brasileira De Hematologia E Hemoterapia, 2008
Molecular studies reveal a concordant KEL genotyping between patients with hemoglobinopathies and blood donors in São Paulo City, Brazil
E. Boturao-Neto, A. K. Chiba, P. Vicari, M. S. Figueiredo, J. O. Bordin
Haematologica, 2008
Genetic polymorphisms of glutathione S-transferase mu1 and theta1 in patients with acquired aplastic anemia: A Brazilian experience
Perla Vicari, Cibele R. Duch, Marily M. A. Shimmoto, Maria Aparecida E. Noguti, Maria Stella Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2007
Study of C282Y, H63D and S65C mutations in the HFE gene in Brazilian patients with iron overload
Rodolfo D. Cançado, Aline C. O. Guglielmi, Carmen S. V. Vergueiro, Ernani G. Rolim, Maria Stella Figueiredo, Carlos S. Chiattone
Revista Brasileira De Hematologia E Hemoterapia, 2007
Modifiers factors of clinical severity in sickle cell anemia
Revista Brasileira De Hematologia E Hemoterapia, 2007
Fetal hemoglobin inducing factors
Revista Brasileira De Hematologia E Hemoterapia, 2007
Sickle cell priapism
Revista Brasileira De Hematologia E Hemoterapia, 2007
Mutations in the HFE gene (C282Y, H63D, S65C) in a Brazilian population
Revista Brasileira De Hematologia E Hemoterapia, 2007
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma
C.R. Duch, M.S. Figueiredo, C. Ribas, M.S.S. Almeida, G.W.B. Colleoni, J.O. Bordin
Brazilian Journal of Medical and Biological Research, 2007
Regression of extramedullary hematopoiesis with hydroxyurea therapy in β-thalassemia intermedia
Revista Brasileira De Hematologia E Hemoterapia, 2006
Fulminant stroke in an adult patient with sickle cell anemia
Perla Vicari, Gisele Sampaio Silva, Rita de Cassia Rosário Cavalheiro, Ayrton Roberto Massaro, Maria Stella Figueiredo
Acta Haematologica, 2006
Migraine-mimicking headache and sickle cell disease: A transcranial Doppler study
GS Silva, P Vicari, MS Figueiredo, HC Junior, MH Idagawa, AR Massaro
Cephalalgia, 2006
Clinical and laboratorial diversity in the bantu haplotype of sickle cell anemia
Paulo J. M. S. Costa, Rosana Q. B. Vilela, Rosana Cipolotti, Maria S. Figueiredo
Revista Brasileira De Hematologia E Hemoterapia, 2006
XmnI polymorphism is associated with fetal hemoglobin levels in hypoplastic syndromes
Marily Maria Azevedo Shimmoto, Perla Vicari, Andréa Cristina Fernandes, Gustavo Stuani Guimarães, Maria Stella Figueiredo
Sao Paulo Medical Journal, 2006
Analysis of HFE gene mutations and HLA-A alleles in Brazilian patients with iron overload
Rodolfo Delfini Cançado, Aline Cristiane de Oliveira Guglielmi, Carmen Silvia Vieitas Vergueiro, Ernani Geraldo Rolim, Maria Stella Figueiredo, Carlos Sérgio Chiattone
Sao Paulo Medical Journal, 2006
Transcranial Doppler in adult patients with sickle cell disease
Gisele Sampaio Silva, Perla Vicari, Maria Stella Figueiredo, Adauto Castelo Filho, Nojan Valadi, Ayrton Roberto Massaro
Cerebrovascular Diseases, 2006
The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease
F. Moreira Neto, D.M. Lourenço, M.A.E. Noguti, V.M. Morelli, I.C.P. Gil, A.C.S. Beltrão, M.S. Figueiredo
Brazilian Journal of Medical and Biological Research, 2006
Effects of hydroxyurea in a population of Brazilian patients with sickle cell anemia
Perla Vicari, Adriana Barretto de Mello, Maria Stella Figueiredo
American Journal of Hematology, 2005
Echocardiographic abnormalities in Brazilian sickle cell patients [5]
Perla Vicari, Rita de Cassia Rosario Cavalheiro, Aparecida de Gouveia, Orlando Campos Filho, Maria Stella Figueiredo
American Journal of Hematology, 2005
Clinical, hematological, and molecular characterization of sickle cell anemia pediatric patients from two different cities in Brazil.
Isa Menezes Lyra, Marilda Souza Gonçalves, Joseffina A. Pellegrinei Braga, Maria de Fátima Gesteira, Maria Helena Carvalho, Sara Terezinha Olalla Saad, Maria Stella Figueiredo, Fernando Ferreira Costa
Cadernos De Saude Publica Ministerio Da Saude Fundacao Oswaldo Cruz Escola Nacional De Saude Publica, 2005
Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
Maria Stella Figueiredo, Perla Vicari, Eliza Yuriko Sugano Kimura, Sandra Vallin Antunes, Mihoko Yamamoto
Sao Paulo Medical Journal, 2004
Myonecrosis in sickle cell anemia: Case report and review of the literature
Perla Vicari, Ruth Achkar, Kathia R.B. Oliveira, Milton L. Miszpupten, Artur R.C. Fernandes, Maria S. Figueiredo, José O. Bordin
Southern Medical Journal, 2004
Application of noninvasive phagocytic cellular assays using autologous monocytes to assess red cell alloantibodies in sickle cell patients
Antonio Fabron, Wilson Baleotti, Adriana B de Mello, Akemi K Chiba, Sachie Kuwano, Maria S Figueiredo, José O Bordin
Transfusion and Apheresis Science, 2004
Embolization of Intracranial Aneurysms and Sickle Cell Disease
Perla Vicari, Ana Cristina C. Choairy, Grazziella C. Siufi, Adriano M. Arantes, José Roberto F. Fonseca, Maria Stella Figueiredo
American Journal of Hematology, 2004
Possible influence of clinical stage and type of treatment in the persistence of residual circulating t(14;18)-positive cells in follicular lymphoma patients
Gisele WB Colleoni, Luiz Cláudio C Duarte, Fábio R Kerbauy, Maria Aparecida E Noguti, Roberta Spetic Felix, José Salvador R De Oliveira, Maria Stella Figueiredo, Antonio Correa Alves
Leukemia and Lymphoma, 2004
Polymorphism of the human platelet antigen-5 system is a risk factor for occlusive vascular complications in patients with sickle cell anemia
V. Castro, F. L. Alberto, R. N. P. Costa, J. Lepikson‐Neto, S. F. M. Gualandro, M. S. Figueiredo, J. M. Annichino‐Bizzacchi, S. T. O. Saad, F. F. Costa
Vox Sanguinis, 2004
Sickle cell trait associated with hereditary spherocytosis: A potentially life-threatening coexistence [1]
Perla Vicari, Adriano M. Arantes, Maria Stella Figueiredo
Acta Haematologica, 2003
Haplotypes of α-globin gene regulatory element in two Brazilian native populations
Daniela M. Ribeiro, Maria S. Figueiredo, Fernando F. Costa, Maria F. Sonati
American Journal of Physical Anthropology, 2003
Septic arthritis as the first sign of Candida tropicalis fungaemia in an acute lymphoid leukemia patient.
Perla Vicari, Ronald Feitosa Pinheiro, Maria de Lourdes Lopes Ferrari Chauffaille, Mihoko Yamamoto, Maria Stella Figueiredo
Brazilian Journal of Infectious Diseases an Official Publication of the Brazilian Society of Infectious Diseases, 2003
Nutritional anemia
Revista Brasileira De Medicina, 2001
Acute promyelocytic leukemia: The study of t(15;17) translocation by fluorescent in situ hybridization, reverse transcriptase-polymerase chain reaction and cytogenetic techniques
M.L.L.F. Chauffaille, M.S. Figueiredo, R. Beltrani, S.V. Antunes, M. Yamamoto, J. Kerbauy
Brazilian Journal of Medical and Biological Research, 2001
Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia
Nelma Cristina Diogo Clementino, Mihoko Yamamoto, Marcos Borato Viana, Maria Stella Figueiredo, Jose Kerbauy, Sara Terezinha Ohlala Saad, Fernando Ferreira Costa
Leukemia and Lymphoma, 2001
Allelic polymorphisms of human Fcγ receptor IIa and Fcγ receptor IIIb among distinct groups in Brazil
Sachie T. Kuwano, José O. Bordin, Akemi K. Chiba, Adriana B. Mello, Maria S. Figueiredo, João P.B. Vieira‐Filho, Antonio Fabron, José Kerbauy
Transfusion, 2000
Detection of trisomy 12 by fluorescent in situ hybridization (FISH) in chronic lymphocytic leukemia
Maria de Lourdes L.F. Chauffaille, Eliana Azevedo Marques, Jose Salvador Rodrigues de Oliveira, Maria Madalena Rodrigues, Maria Stella Figueiredo, Maura Romeo, Mihoko Yamamoto, José Kerbauy
Genetics and Molecular Biology, 2000
Anemia
Revista Brasileira De Medicina, 1998
Toxic epidermal necrolysis after the use of intermediate dose of cytosine arabinoside
Revista Da Associacao Medica Brasileira 1992, 1998
Renal dysfunction in patients with sickle cell anemia or sickle cell trait
R. Sesso, M.A. Almeida, M.S. Figueiredo, J.O. Bordin
Brazilian Journal of Medical and Biological Research, 1998
Spinal cord compression in beta-thalassemia: follow-up after radiotherapy.
Silvana Fahel da Fonseca, Maria Stella Figueiredo, Rodolfo Delfini Cançado, Fernando Nakandakare, Roberto Segreto, José Kerbauy
Sao Paulo Medical Journal Revista Paulista De Medicina, 1998
Genetic analysis of β-thalassemia major and β-thalassemia intermedia in Brazil
S. F. Fonseca, J. Kerbauy, C. Escrivao, M. S. Figueiredo, R. Cancado, V. R. Arruda, S. T. O. Saad, F. F. Costa
Hemoglobin, 1998
Fetal hemoglobin in sickle cell anemia: Examination of phylogenetically conserved sequences within the locus control region but outside the cores of hypersensitive sites 2 and 3
Maria Plonczynski, Maria Stella Figueiredo, Martin H. Steinberg
Blood Cells Molecules and Diseases, 1997
Hb Köln [α2β298(FG5) val-met] identified by DNA analysis in a Brazilian family
Silvia R.P. Miranda, Silvana F. Fonseca, Maria S. Figueiredo, Myoko Yamamoto, Helena Z.W. Grotto, Sara T.O. Saad, Fernando F. Costa
Brazilian Journal of Genetics, 1997
Effect of α-thalassemia and β-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil
M.S. Figueiredo, J. Kerbauy, M.S. Gonçalves, V.R. Arruda, S.T.O. Saad, M.F. Sonati, T. Stoming, F.F. Costa
American Journal of Hematology, 1996
Fetal hemoglobin in patients with chronic renal disease
Brazilian Journal of Medical and Biological Research, 1996
Molecular identification of hereditary persistence of fetal hemoglobin type 2 (HPFH type 2) in patients from Brazil
M. S. Gonçalves, S. Fahel, M. S. Figueiredo, E. J. Kimura, F. Nechtman, T. A. Stoming, V. R. Arruda, S. T. O. Saad, F. F. Costa
Annals of Hematology, 1995
Glucose-6-phosphate dehydrogenase deficiency in sickle cell disease by DNA analysis [5]
ST Saad, FF Costa, TS Salles, MF Sonatti, MS Figueiredo
Blood, 1995
Hb Lepore(Baltimore) (δ50Ser β86Ala) identified by DNA analysis in a Brazilian family
S.R.P. Miranda, M.S. Figueiredo, J. Kerbauy, H.Z.W. Grotto, S.T.O. Saad, F.F. Costa
Acta Haematologica, 1994
Sickle cell disease in a brazilian population from sao paulo: A study of the βs haplotypes
M.S. Goncalves, J.F. Nechtman, M.S. Figueiredo, J. Kerbauy, V.R. Armda, M.F. Sonati, S.O.T. Saad, F.F. Costa, T.A. Stoming
Human Heredity, 1994

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