Dr. Siva Durairaj
@siva.d.clatr@sathyabama.ac.in
Assistant Professor (Research), Centre for Laboratory Animal Technology and Research, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
A Researcher with a profound expertise in the fields of Ecotoxicogenomics. Nanobiotechnology and Phytomedicine. The primary area of expertise lies in scrutinizing the molecular-level toxic impacts of Pharmaceutical and Personal Care Products (PPCPs) using in vivo animal experiments. Additionally, I have a distinct proficiency in assessing the medicinal properties of diverse herbal extracts and their bioactive constituents across a wide range of disease models such as anticancer, antidiabetic, reproductive toxicity, cardioprotective, hepatocurative, antiurolithiasis, obesity, antiarthritic, and wound healing studies.
EDUCATION
Ph.D.,
Environmental Biotechnology
Department of Environmental Biotechnology
Bharathidasan University
2013 to 2019
P.G Diploma
Environmental Genomics
Department of Environmental Biotechnology
Bharathidasan University
2011 to 2012
M. Phil.,
Environmental Biotechnology
Department of Environmental Biotechnology
Bharathidasan University
2010 to 2011
M. Sc.,
Eco-Biotechnology
Department of Environmental Biotechnology
Bharathidasan University
2008 to 2010
B. Sc.,
Biotechnology
Department of Biotechnology
Ponnaiyah Ramajayam College
Thanjavur – 614 904
2005 to 2008
RESEARCH, TEACHING, or OTHER INTERESTS
Biotechnology, Biomedical Engineering, Biomaterials, Pharmacology, Toxicology and Pharmaceutics
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
C. Jayaseelan, D. Siva, C. Kamaraj, R. Thirugnanasambandam, V. Ganesh Kumar, B. Subashni, R. Ashokkumar, and D. Saravanan
Elsevier BV
Chidambaram Jayaseelan, Pooja Upadhyay, Dinkar Sahal, Chinnaperumal Kamaraj, Rajendran Thirugnanasambandam, Durairaj Siva, Durai Saravanan, and Rathinasamy Regina Mary
Elsevier BV
Durairaj Siva, Subramanian Abinaya, Durairaj Rajesh, Govindaraju Archunan, Parasuraman Padmanabhan, Balázs Gulyás, and Shanmugam Achiraman
MDPI AG
Doxorubicin is an extensively prescribed antineoplastic agent. It is also known for adverse effects, among which cardiotoxicity tops the list. The possible mechanism underlying doxorubicin (DOX)-mediated cardiotoxicity has been investigated in this study. Further, to reduce the DOX-mediated cardiotoxicity, DOX was conjugated with Chitosan Nanoparticles (DCNPs) and supplemented with propionic acid. Initially, the drug loading efficacy and conjugation of DOX with chitosan was confirmed by UV–Visible Spectroscopy (UV) and Fourier Transform Infrared Spectroscopy (FTIR). The average sizes of the synthesized Chitosan Nanoparticles (CNPs) and DCNPs were measured by Dynamic Light Scattering (DLS) analysis as 187.9 ± 1.05 nm and 277.3 ± 8.15 nm, respectively, and the zeta potential values were recorded as 55.2 ± 0.7 mV and 51.9 ± 1.0 mV, respectively. The size and shape of CNPs and DCNPs were recorded using a High-Resolution Electron Microscopy (HRTEM). The particles measured <30 nm and 33–84 nm, respectively. The toxic effects of DCNPs and propionic acid were evaluated in rat model. The data from the electrocardiogram (ECG), cardiac biomarkers, Peroxisome proliferator-activated receptor gamma (PPARγ) and histological observations indicated evidence of DOX-mediated cardiotoxicity, whereas the administration of DCNPs, as well as Propionic Acid (PA), brought about a restoration to normalcy and offered protection in the context of DOX-induced cardiotoxicity.
Durairaj Siva, Gunasekaran Srivethi, Poovanalingam Thirumalai Vasan, Durairaj Rajesh, Ahmed Alfarhan, and Rajakrishnan Rajagopal
Elsevier BV
Uma Maheshwari Rajadurai, Abirami Hariharan, Siva Durairaj, Fuad Ameen, Turki Dawoud, Suaad Alwakeel, Ilamathy Palanivel, Lakshmi Prabha Azhagiyamanavalan, and Joe Antony Jacob
Elsevier BV
Abbirami Elangovan, Siva Durairaj, Abinaya Subramanian, Sooraj Ramakrishnan, Dinesh Kumar Lakshmanan, Guna Ravichandran, and Sivasudha Thilagar
Springer Science and Business Media LLC
Hui Huang, Kuizhong Shan, Jingbing Liu, Xiaoxin Tao, Sivalingam Periyasamy, Siva Durairaj, Ziyu Jiang, and Joe Antony Jacob
Elsevier BV
Abbirami Elangovan, Abinaya Subramanian, Siva Durairaj, Jeyadevi Ramachandran, Dinesh Kumar Lakshmanan, Guna Ravichandran, Gayathri Nambirajan, and Sivasudha Thilagar
Elsevier BV
Padmanabhan RathnaKumari, Pachaan Kolanchinathan, Durairaj Siva, Bethunaickan Abirami, Vivekanandan Masilamani, George John, Shanmugam Achiraman, and Athmanathan Balasundaram
Elsevier BV
Durairaj Rajesh, Subramanian Muthukumar, Ganesan Saibaba, Durairaj Siva, Mohammad Abdulkader Akbarsha, Balázs Gulyás, Parasuraman Padmanabhan, and Govindaraju Archunan
Springer Science and Business Media LLC
AbstractTransportation of pheromones bound with carrier proteins belonging to lipocalin superfamily is known to prolong chemo-signal communication between individuals belonging to the same species. Members of lipocalin family (MLF) proteins have three structurally conserved motifs for delivery of hydrophobic molecules to the specific recognizer. However, computational analyses are critically required to validate and emphasize the sequence and structural annotation of MLF. This study focused to elucidate the evolution, structural documentation, stability and binding efficiency of estrus urinary lipocalin protein (EULP) with endogenous pheromones adopting in-silico and fluorescence study. The results revealed that: (i) EULP perhaps originated from fatty acid binding protein (FABP) revealed in evolutionary analysis; (ii) Dynamic simulation study shows that EULP is highly stable at below 0.45 Å of root mean square deviation (RMSD); (iii) Docking evaluation shows that EULP has higher binding energy with farnesol and 2-iso-butyl-3-methoxypyrazine (IBMP) than 2-naphthol; and (iv) Competitive binding and quenching assay revealed that purified EULP has good binding interaction with farnesol. Both, In-silico and experimental studies showed that EULP is an efficient binding partner to pheromones. The present study provides impetus to create a point mutation for increasing longevity of EULP to develop pheromone trap for rodent pest management.
Jacob Joe Antony, Murugaiyan Nivedheetha, Durairaj Siva, Ganesapandy Pradeepha, Palanivel Kokilavani, Seenivasan Kalaiselvi, Arunachalam Sankarganesh, Athmanathan Balasundaram, Vivekanandan Masilamani, and Shanmugam Achiraman
Elsevier BV
Jaganathan Sripriya, Sundaramurthy Anandhakumar, Shanmugam Achiraman, Jacob Joe Antony, Durairaj Siva, and Ashok M. Raichur
Elsevier BV
Jacob Joe Antony, Murugaiyan Nivedheetha, Durairaj Siva, Ganesapandy Pradeepha, Palanivel Kokilavani, Seenivasan Kalaiselvi, Arunachalam Sankarganesh, Athmanathan Balasundaram, Vivekanandan Masilamani, and Shanmugam Achiraman
Elsevier BV
Jacob Joe Antony, Mohamed Ali Ayisha Sithika, Thomas Amal Joseph, Udhayaraj Suriyakalaa, Arunachalam Sankarganesh, Durairaj Siva, Seenivasan Kalaiselvi, and Shanmugam Achiraman
Elsevier BV
Udhayaraj Suriyakalaa, Jacob Joe Antony, Subramanian Suganya, Durairaj Siva, Raman Sukirtha, Soundarrajan Kamalakkannan, P.B. Tirupathi Pichiah, and Shanmugam Achiraman
Elsevier BV
Periyasamy Sivalingam, Jacob Joe Antony, Durairaj Siva, Shanmugam Achiraman, and Kumarasamy Anbarasu
Elsevier BV
Jacob Joe Antony, Periyasamy Sivalingam, Durairaj Siva, Soundararajan Kamalakkannan, Kumarasamy Anbarasu, Raman Sukirtha, Muthukalingan Krishnan, and Shanmugam Achiraman
Elsevier BV