Assistant of the Department of Propaedeutic of Childhood Diseases, Clinical Institute of Children’s Health named after N.F.Filatov I.M.Sechenov First Moscow State Medical University (Sechenov University)
Parental Attitudes Towards Vaccination in Children with Inflammatory Bowel Disease: A Comparative Study Svetlana I. Erdes, Ivan S. Samolygo, Mikhail P. Kostinov, Olga L. Lomakina, Ekaterina A. Yablokova, Anton S. Antishin, Albina S. Pestova, Viktoria S. Krikun, Yulia A. Drozdova, Elena V. Borisova, Marina A. Manina Children, 2026 Objective: To evaluate parental attitudes towards vaccination in children with inflammatory bowel disease (IBD), assess the level of adherence to immunization schedules, and identify key barriers hindering vaccination. Materials and Methods: A comparative survey was conducted involving 215 respondents, divided into an IBD group (109 parents of children with IBD) and a control group (106 parents of healthy children). The majority of respondents were mothers (96%) with higher education (81% and 79%, respectively) residing in a major metropolitan area. We assessed demographic data, vaccination history of both children and parents, sources of medical information, and reasons for vaccine refusal. Results: Routine vaccination coverage in children under 6 years of age was high and comparable in both groups (>93%). The majority of parents in the IBD group (n = 68; 62%) expressed a positive attitude towards vaccination. However, following the onset of IBD, only 24 (22%) continued vaccination, while 85 (78%) reported a categorical refusal to continue immunization. It was found that parents tend to misinterpret normal post-vaccination reactions as vaccine complications. A significant factor contributing to refusal is the lack of information from attending physicians and reliance on the Internet as a primary information source. Additionally, low rates of adult revaccination were noted, with over 30% of parents in both groups not being vaccinated in adulthood. Conclusions: The low vaccination rate in children with IBD after disease onset is driven not by initial anti-vaccination sentiment, but by acquired fears and a lack of professional communication from primary care providers and specialists. Improving immunization coverage requires the active implementation of educational programs for parents regarding vaccine safety during immunosuppressive therapy, as well as the development of specific guidelines for attending physicians.
Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study I. S. Samolygo, M. Manina, Ekaterina A. Yablokova, Pavel A. Stribul, Alexander V. Novikov, A. Antishin, A. S. Pestova, A. Tertychnyy, D. Munblit, Svetlana I. Erdes Children, 2025 Background: Inflammatory bowel diseases with an early-onset form (EO-IBDs) make up a special disease group with certain clinical and phenotypic characteristics. This article discusses the features of such early onset in a group of children, based on five years of monitoring a registry of children with IBD from a specialized center. Methods: This retrospective single-center cohort study included pediatric patients diagnosed with EO-IBD between 2019 and 2024. Clinical, laboratory, and endoscopic data were collected from medical records, including fecal calprotectin, inflammatory markers, disease activity indices, and endoscopic severity scores. Localization was classified according to the Paris system, and histological activity was assessed using the IBD-DCA score. Results: There were 20 patients with ulcerative colitis (UC) and 17 with Crohn’s disease (CD). Clinical activity was moderate or high (p = 0.179). UC was more characterized by diarrhea and rectal bleeding. CD was more often accompanied by abdominal pain, weight loss, and fever. In total, 82.4% of patients with CD had an inflammatory form. UC-like intestinal lesion was typical of both nosologies—L3 64.7% and E4 60% forms in CD and UC, respectively. Morphological activity was moderate for both nosologies (p = 0.54). IBD-U was present in 43.2% of patients. The median time after which it was possible to diagnose UC was 24 weeks (IQR 20–48) and 40 weeks (IQR 30–45.5) for CD (p = 0.56). Conclusions: Our study confirms the presence of characteristic signs of EO-IBD development, such as a frequent family history of IBD, high or moderate clinical activity during diagnosis verification, colon damage, and a high frequency of extraintestinal manifestations.
Modern challenges of preventive vaccination in children: From epidemiological trends to social barriers: Literature review , I.S. Samolygo, K.A. Andrianova,, , M.A. Manina, , A.S. Pestova, , S.I. Erdes, and Russian Journal of Woman and Child Health, 2025 Focus on health of children and adolescents is a key part of socio-demographic policy of any state. Preventive vaccination remains one of the most efficient public healthcare tools that can significantly reduce infection dissemination and child mortality. The review highlights current trends, issues and challenges facing the healthcare system in the Russian Federation and worldwide. An alarming increase in morbidity of vaccine-preventable infections including measles, pertussis, pneumococcal and rotavirus infections associated with decreased vaccination coverage, increasing anti-vaccination trends, global migration and the COVID-19 pandemic effects is reported. Analysis of current national vaccination schedules, vaccination coverage, reasons for immunization refusals, as well as specific features of immune response formation in children with various immunobiological agents is presented. Special attention should be given to importance of comprehensive preventive work including not only extended vaccination schedules, but also enhanced educational and public awareness activities among parents and a medical community. A need for systemic measures to increase confidence in vaccination, to ensure equal access to vaccines, and to improve immunization coverage in children is emphasized KEYWORDS: pediatric health, preventive vaccination, vaccine-preventable infections, vaccination, measles, pertussis, pneumococcus, rotavirus FOR CITATION: Samolygo I.S., Andrianova K.A., Manina M.A., Pestova A.S., Erdes S.I. Modern challenges of preventive vaccination in children: from epidemiological trends to social barriers: literature review. Russian Journal of Woman and Child Health. 2025;8(4):366–371 (in Russ.). DOI: 10.32364/2618-8430-2025-8-4-13
Features of the duration of COVID-19 pneumonia in children under three months of age Anastasiia Bairashevskaia, A.I. Aminova, T.Yu. Eryushova, Б. О. Мацукатова, A.S. Pestova, et al. Voprosy Prakticheskoi Pediatrii, 2024 COVID-19 infection remains an actual problem in pediatric practice today. Objective. To study the features of the course of this infection in newborns and infants. Patients and methods. A retrospective cohort study included 53 children under the age of 3 months with radiologically confirmed pneumonia. All children were divided into two groups: the main COV (32 children) with confirmed coronavirus infection, and the control NCOV (21 children) without this diagnosis. When analyzing clinical symptoms (runny nose, cough, fever, nausea, vomiting, weakness, lethargy, shortness of breath), it was not possible to establish statistically significant differences. A statistically significant was revealed when comparing the symptom of diarrhea (p = 0.015). Diarrhea could be explained by damage to the dense contacts of enterocytes. Results. Patients in the COV group had leukopenia with a t value of 9.6·109/l at+ normal values of neutrophils and lymphocytes. Lung lesions were not detected at high basophil values, which suggests a protective function of basophils in toddlers. Conclusion. COVID-19 coronavirus infection in children under 3 months has not yet been sufficiently studied and characterized by non-specific symptoms. To date, data on pathogenesis and clinical manifestations in this age group remain contradictory, which requires additional research. Key words: infants, diarrhea, COVID-19, newborns, pneumonia
Malignant whooping cough in a palliative patient A.S. Pestova, Alfiya I. Aminova, Alexander S. Akopyan, German V. Berdnikov, Anna A. Gruzintseva Clinical Review for General Practice, 2023 Whooping cough is a highly contagious respiratory disease. despite ongoing vaccination, the disease is endemic in developing and developed countries. newborns and children who are not vaccinated or partially immunized become most severely ill. The severity of symptoms depends on factors such as the patient's age, the strength of the immune response, and the degree of systemic bacterial dissemination. The most severe form of pertussis is malignant pertussis, which is characterized by large leukocytosis, refractory hypoxemia, pulmonary hypertension and cardiopulmonary impairment. This article is devoted to the clinical observation of a patient with a malignant course of whooping cough.
The relationship between the quality of life of medical students and their academic performance Zarnigar F. Gumbatova, Alfiya I. Aminova, Tatyana Yu. Eryushova, Susanna A. Guseva, Ekaterina I. Belova, Albina S. Pestova, Marina A. Manina Gigiena I Sanitariya, 2022 Introduction. According to modern literature data, the quality of life of medical students is significantly lower than in the general population. Poor quality of life affects academic performance and can lead to rapid burnout. In this regard, an urgent problem is to study the practical significance of the impact of academic performance on the quality of life of students enrolled in medical universities, to improve their level of professional training. Materials and methods. With the help of the SF-36 questionnaire, 290 2nd year students of the pediatric faculty of the Medical University were examined. Students’ performance was assessed based on the results of an objective structured clinical examination (OSCE) and an average examination grade for 1-3 semesters. All students are divided into three groups - best, mediocres and worst. Results. For successful students, a high level of emotional state did not interfere with the performance of daily activities. The total physical component of health was the highest among average students. Students with poor academic performance had a minimal total mental health component, which indicated that they had depressive states and bad mood. It was found that the deterioration of academic performance led to a violation of the performance of daily activities, a sharp limitation of social contacts and the level of communication. A high level of academic performance correlated with low vital activity, increasing fatigue and disadaptation. Limitations. This study is limited to a selection of students studying at medical universities and undergoing an assessment of the quality of education with the help of OSCE. Conclusion. The quality of life, health status and academic performance of students are interdependent indicators. The use of questionnaires will reveal the reasons for the decline in working capacity associated with the deterioration in the quality of life.