Giorgia Conte

@isof.cnr.it

Institute for Organic Synthesis and Photoreactivity
italian national council of research

Giorgia Conte


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https://researchid.co/giorgiaco

RESEARCH, TEACHING, or OTHER INTERESTS

Neuroscience, Materials Science, Molecular Biology, Cell Biology
25

Scopus Publications

512

Scholar Citations

13

Scholar h-index

13

Scholar i10-index

Scopus Publications

  • Protein-Template Gold Nanoclusters Induce Differentiation and Modify the Functional Properties of Primary Astrocytes
    Roberta Fabbri, Karima Jeneh Perry, Emanuela Saracino, Chiara Lazzarini, Anna Mariano, et al.
    Advanced Nanobiomed Research, 2026
    Astrocyte ion channels, water channels, and calcium signaling play vital roles in maintaining brain homeostasis, coordinating neural network activity, supporting cognitive functions, and mediating neurovascular coupling. Disruptions in astrocyte dynamics are causally linked to gliosis occurring in pathologies, such as brain injuries and neurological diseases. Despite their importance, the potential to probe and modulate astrocyte molecular, functional, and morphological properties using intracellular light adsorbing nanoscale interfaces has been limited. In this study, we investigate the effects of fluorescent gold nanoclusters (fAuNCs) bound to bovine serum albumin (BSA) on the morphological, molecular, and functional properties of primary rat cortical astrocytes over an extended period. Treatment with fAuNCs‐BSA is not toxic over long term and induces notable morphological changes alongside alterations in whole‐cell chloride currents, cell volume regulation, and calcium signaling magnitude. To leverage the light‐absorbing properties of fAuNCs‐BSA, we expose acutely fAuNCs‐BSA‐treated astrocytes to LED blue light (λ_ex = 450 nm), which modulates potassium currents. Nanodiamond thermometry suggests that this effect results from local heating caused by photoexcitation of the nanoclusters. The potential of nanoclusters as a transformative approach for studying astrocyte function and their role in the biophysical mechanisms underlying neural communication is discussed.
  • Reply to: On the interpretation of astrocytic calcium signalling with graphene oxide electrodes
    Roberta Fabbri, Alessandra Scidà, Emanuela Saracino, Giorgia Conte, Alessandro Kovtun, Andrea Candini, Denisa Kirdajova, Diletta Spennato, Valeria Marchetti, Chiara Lazzarini, Aikaterini Konstantoulaki, Paolo Dambruoso, Marco Caprini, Michele Muccini, Mauro Ursino, Miroslava Anderova, Emanuele Treossi, Roberto Zamboni, Vincenzo Palermo, Valentina Benfenati
    Nature Nanotechnology, 2026
  • Label-Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes
    Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander
    Advanced Science, 2026
    Astrocyte cell differentiation to their characteristic starlike morphology with the expression of proteins in microdomains, critical for normal brain function, occurs naturally in‐vivo but can be affected in pathological condition or in cell culture in‐vitro. Analyzing the molecular composition and functional properties of astrocytes in a label‐free manner with sub‐micron spatial resolution can enable detailed insights into their role in brain physio‐pathology. However, simultaneous insights into any structural, molecular, and functional features in unlabelled differentiated astrocytes, without perturbing their natural environment with exogenous tags, has been limited. Using mid‐infrared photothermal imaging, an accumulation of α‐helical signatures for the extended astrocyte processes is observed in differentiated astrocytes on a nanomaterials interface. At the same time, non‐differentiated astrocytes feature a more diverse protein content, rich in β ‐sheets. Time‐resolved photothermal diffusion measurements indicate a higher interfacial thermal resistance at the astrocyte processes, connecting protein structure with thermal relaxation dynamics experimentally within the same measurement, critical for energy transport and homeostasis. This photothermal multi‐parameter characterization offers unique insights into what chemically and functionally determines healthy astrocytes, paving the way towards a deeper understanding of their differentiation mechanisms. This method allows for the detection of molecular, morphological, and functional signatures associated with pathological state of astrocytes ex‐vivo.
  • Corrigendum to “Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice” [Brain Behav. Immun. 120 (2024) 121–140, (S0889159124004136), (10.1016/j.bbi.2024.05.023)]
    Mariana Alves, Beatriz Gil, Javier Villegas-Salmerón, Valentina Salari, Ricardo Martins-Ferreira, Marina Arribas Blázquez, Aida Menéndez Méndez, Rogerio Da Rosa Gerbatin, Jonathon Smith, Laura de Diego-Garcia, Giorgia Conte, Juan Sierra-Marquez, Paula Merino-Serrais, Meghma Mitra, Ana Fernandez Martin, Yitao Wang, Jaideep Kesavan, Ciara Melia, Alberto Parras, Edward Beamer, Béla Zimmer, Mona Heiland, Brenton Cavanagh, Rafael Parcianello Cipolat, James Morgan, Xinchen Teng, Jochen H.M. Prehn, Paolo F. Fabene, Giuseppe Bertini, Antonio R. Artalejo, Esteban Ballestar, Annette Nicke, Luis A. Olivos-Oré, Niamh M.C. Connolly, David C. Henshall, Tobias Engel
    Brain Behavior and Immunity, 2025
  • Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures
    Ivano Lucarini, Francesco Maita, Giorgia Conte, Emanuela Saracino, Francesco Formaggio, Elena Palmieri, Roberta Fabbri, Aikaterini Konstantoulaki, Chiara Lazzarini, Marco Caprini, Valentina Benfenati, Luca Maiolo, Annalisa Convertino
    Advanced Healthcare Materials, 2025
    Primary dorsal root ganglion (DRG) cell cultures provide a valuable model for studying in vitro sensory transduction, neuropathies, and chronic pain, as they replicate the in vivo heterogeneity of DRG neurons and non‐neuronal cells. However, traditional patch‐clamp techniques are invasive and cannot capture the collective cell dynamics. While planar multielectrode arrays (MEAs) offer a non‐invasive alternative, they suffer from poor cell‐electrode coupling and limited resolution for identifying specific DRG neuronal types like C‐fiber nociceptors, key targets in chronic pain research. This work demonstrates that silicon nanowire (SiNW) mat‐based MEAs, while maintaining their reduced invasiveness, enable continuous intracellular recordings from neurons in primary rat DRG cell cultures. Supported by a cortical astrocyte feeder layer, SiNW mats promote DRG neuron and glial cell growth preserving cells’ in vivo morphological and functional characteristics. Integrated into a compartmentalized MEA, they enable reliable recordings of drug‐modulated neuronal activity alongside a baseline related to the astrocyte layer. The recorded signals exhibit characteristics of intracellular action potentials, suggesting spontaneous intracellular access by SiNWs. Distinct electrophysiological signatures allow identifying C‐fiber nociceptors, as confirmed by patch‐clamp measurements. This platform represents a powerful tool for investigating in vitro pain mechanisms, with potential applications in preclinical pain research and pharmacological translational studies.
  • Astrocytes: Multiscale Molecular Targets for Glial Engineering and Interfaces
    Aikaterini Konstantoulaki, Roberta Fabbri, Giorgia Conte, Chiara Lazzarini, Valentina Benfenati
    Glial Engineering and Glial Interfaces Targeting the Role of Astrocytes and Other Glial Cells in Brain Function and Dysfunctions, 2025
  • Mid-Infrared Photothermal Imaging of Secondary Protein Structure in Differentiated Astrocytes
    Panagis D. Samolis, Bahar Durgun, Chiara Lazzarini, Giorgia Conte, Barbara Barile, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander
    2025 Conference on Lasers and Electro Optics CLEO 2025, 2025
    With label-free mid-infrared photothermal imaging, alpha-helical accumulations within the fibril extensions of differentiated astrocytes are identified, whereas the cell cytoplasm features a more equal expression of alpha-helical and beta-sheet structures.
  • Mid-Infrared Photothermal Imaging of Secondary Protein Structure in Differentiated Astrocytes
    Panagis D. Samolis, Bahar Durgun, Chiara Lazzarini, Giorgia Conte, Barbara Barile, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander
    CLEO Applications and Technology Proceedings CLEO 2025, 2025
    With label-free mid-infrared photothermal imaging, alpha-helical accumulations within the fibril extensions of differentiated astrocytes are identified, whereas the cell cytoplasm features a more equal expression of alpha-helical and beta-sheet structures.
  • P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice
    Mariana Alves, Laura de Diego-Garcia, Gloria Vegliante, Oscar Moreno, Beatriz Gil, Pedro Ramos-Cabrer, Meghma Mitra, Ana Fernandez Martin, Aida Menéndez-Méndez, Yitao Wang, Nathan Ryzewski Strogulski, Meng-Juan Sun, Ciara Melia, Giorgia Conte, Sandra Plaza-García, Igor Khalin, Xinchen Teng, Nikolaus Plesnila, Bert Klebl, Klaus Dinkel, Michael Hamacher, Anindya Bhattacharya, Marc Ceusters, James Palmer, David J. Loane, Jordi Llop, David C. Henshall, Tobias Engel
    Theranostics, 2025
    Purpose: Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel that is expressed throughout the brain. While increasing evidence suggests a role for the P2X7R during seizures and epilepsy, it is unclear if changes in P2X7R expression can predict TBI-induced epilepsy development, and whether P2X7R antagonism can protect against long-lasting brain hyperexcitability caused by TBI. Methods: TBI was induced in adult male mice using the controlled cortical impact model (CCI). To test the anti-epileptogenic effects of P2X7R antagonism, mice were treated with brain-penetrant P2X7R antagonists JNJ-54175446 (30 mg/kg) or AFC-5128 (30 mg/kg) for 7 days post-CCI. The cell-type specific effects of P2X7Rs on TBI-induced hyperexcitability were analyzed in mice lacking exon 2 of the P2rx7 gene selectively in microglia (P2rx7:Cx3cr1-Cre). Static positron emission tomography (PET) via an intravenous injection of the P2X7R radioligand 18F-JNJ-64413739 and magnetic resonance imaging (MRI) were conducted twice during the first- and third-week post-injury. Results: Following TBI, while there were no obvious changes in P2X7R protein levels in the ipsilateral hippocampus post-injury, there was a delayed increase in P2X7R protein levels in the ipsilateral cortex at 3 months post-injury. Treatment with P2X7R antagonists shortly after TBI reduced long-lasting brain hyperexcitability, reduced cortical contusion volume, and normalized injury-induced hyperactivity to control sham-levels at 3 weeks post-TBI. Notably, mice lacking P2rx7 in microglia had an increased seizure threshold after TBI, suggesting that P2X7R contributed to brain hyperexcitability via its effects on microglia. Finally, P2X7R radioligand uptake after TBI correlated with seizure threshold at 3 weeks post-injury. Conclusions: Our results demonstrate the antiepileptogenic potential of P2X7R antagonism to prevent TBI-induced epilepsy and indicate that P2X7R-based PET imaging may be a useful diagnostic tool to identify people at risk of developing PTE.
  • Correction to: Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes (Nature Nanotechnology, (2024), 19, 9, (1344-1353), 10.1038/s41565-024-01711-4)
    Roberta Fabbri, Alessandra Scidà, Emanuela Saracino, Giorgia Conte, Alessandro Kovtun, Andrea Candini, Denisa Kirdajova, Diletta Spennato, Valeria Marchetti, Chiara Lazzarini, Aikaterini Konstantoulaki, Paolo Dambruoso, Marco Caprini, Michele Muccini, Mauro Ursino, Miroslava Anderova, Emanuele Treossi, Roberto Zamboni, Vincenzo Palermo, Valentina Benfenati
    Nature Nanotechnology, 2024
    In the version of this article initially published, the present address for Valeria Marchetti (Second Faculty of Medicine, Charles University, Prague, Czech Republic) was missing and is now included in the HTML and PDF versions of the article.
  • Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes
    Roberta Fabbri, Alessandra Scidà, Emanuela Saracino, Giorgia Conte, Alessandro Kovtun, Andrea Candini, Denisa Kirdajova, Diletta Spennato, Valeria Marchetti, Chiara Lazzarini, Aikaterini Konstantoulaki, Paolo Dambruoso, Marco Caprini, Michele Muccini, Mauro Ursino, Miroslava Anderova, Emanuele Treossi, Roberto Zamboni, Vincenzo Palermo, Valentina Benfenati
    Nature Nanotechnology, 2024
  • Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
    Mariana Alves, Beatriz Gil, Javier Villegas-Salmerón, Valentina Salari, Ricardo Martins-Ferreira, Marina Arribas Blázquez, Aida Menéndez Méndez, Rogerio Da Rosa Gerbatin, Jonathon Smith, Laura de Diego-Garcia, Giorgia Conte, Juan Sierra-Marquez, Paula Merino Serrais, Meghma Mitra, Ana Fernandez Martin, Yitao Wang, Jaideep Kesavan, Ciara Melia, Alberto Parras, Edward Beamer, Béla Zimmer, Mona Heiland, Brenton Cavanagh, Rafael Parcianello Cipolat, James Morgan, Xinchen Teng, Jochen H.M. Prehn, Paolo F. Fabene, Giuseppe Bertini, Antonio R. Artalejo, Esteban Ballestar, Annette Nicke, Luis A. Olivos-Oré, Niamh M.C. Connolly, David C. Henshall, Tobias Engel
    Brain Behavior and Immunity, 2024
  • The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice
    Jonathon Smith, Aida Menéndez Méndez, Mariana Alves, Alberto Parras, Giorgia Conte, Anindya Bhattacharya, Marc Ceusters, Annette Nicke, David C. Henshall, Eva M. Jimenez‐Mateos, Tobias Engel
    British Journal of Pharmacology, 2023
  • The emerging science of Glioception: Contribution of glia in sensing, transduction, circuit integration of interoception
    R. Fabbri, Diletta Spennato, Giorgia Conte, Aikaterini Konstantoulaki, C. Lazzarini, E. Saracino, G. P. Nicchia, A. Frigeri, Roberto Zamboni, D. Spray, V. Benfenati
    Pharmacology and Therapeutics, 2023
  • Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice
    Edward Beamer, James Morgan, Mariana Alves, Aida Menéndez Méndez, Gareth Morris, Béla Zimmer, Giorgia Conte, Laura de Diego‐Garcia, Cristina Alarcón‐Vila, Nico Ka Yiu Ng, Stephen Madden, Francesco Calzaferri, Cristóbal de los Ríos, Antonio G. García, Michael Hamacher, Klaus Dinkel, Pablo Pelegrín, David C. Henshall, Annette Nicke, Tobias Engel
    British Journal of Pharmacology, 2022
  • Circulating p2x7 receptor signaling components as diagnostic biomarkers for temporal lobe epilepsy
    Giorgia Conte, Aida Menéndez-Méndez, Sebastian Bauer, Hany El-Naggar, Mariana Alves, Annette Nicke, Norman Delanty, Felix Rosenow, David C. Henshall, Tobias Engel
    Cells, 2021
  • Elevated blood purine levels as a biomarker of seizures and epilepsy
    Edward Beamer, Austin Lacey, Mariana Alves, Giorgia Conte, Faming Tian, Laura de Diego‐Garcia, Mohamed Khalil, Felix Rosenow, Norman Delanty, Nicholas Dale, Hany El‐Naggar, David C. Henshall, Tobias Engel
    Epilepsia, 2021
  • High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy
    Giorgia Conte, Alberto Parras, Mariana Alves, Ivana Ollà, Laura De Diego‐Garcia, Edward Beamer, Razi Alalqam, Alejandro Ocampo, Raúl Mendez, David C. Henshall, José J. Lucas, Tobias Engel
    Epilepsia, 2020
  • Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model
    Antonio Ramírez-Fernández, Lidia Urbina-Treviño, Giorgia Conte, Mariana Alves, Björn Rissiek, Anna Durner, Nicolas Scalbert, Jiong Zhang, Tim Magnus, Friedrich Koch-Nolte, Nikolaus Plesnila, Jan M. Deussing, Tobias Engel, Robin Kopp, Annette Nicke
    Scientific Reports, 2020
  • Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse
    James Morgan, Mariana Alves, Giorgia Conte, Aida Menéndez-Méndez, Laura de Diego-Garcia, Gioacchino de Leo, Edward Beamer, Jonathon Smith, Annette Nicke, Tobias Engel
    Neuroscience Bulletin, 2020
  • P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice
    Giorgia Conte, Ngoc T. Nguyen, Mariana Alves, Laura de Diego-Garcia, Aidan Kenny, Annette Nicke, David C. Henshall, Eva M. Jimenez-Mateos, Tobias Engel
    Frontiers in Molecular Neuroscience, 2020
  • Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy
    Alberto Parras, Laura de Diego-Garcia, Mariana Alves, Edward Beamer, Giorgia Conte, Eva M Jimenez-Mateos, James Morgan, Ivana Ollà, Yasmina Hernandez-Santana, Norman Delanty, Michael A Farrell, Donncha F O’Brien, Alejandro Ocampo, David C Henshall, Raúl Méndez, José J Lucas, Tobias Engel
    Brain, 2020
  • On the mechanism of the electrophysiological changes and membrane lesions induced by asbestos fiber exposure in Xenopus laevis oocytes
    Annalisa Bernareggi, Giorgia Conte, Andrew Constanti, Violetta Borelli, Francesca Vita, Giuliano Zabucchi
    Scientific Reports, 2019
  • ATP release during seizures – A critical evaluation of the evidence
    Edward Beamer, Giorgia Conte, Tobias Engel
    Brain Research Bulletin, 2019
  • Context-specific switch from anti- to pro-epileptogenic function of the P2Y1 receptor in experimental epilepsy
    Mariana Alves, Laura De Diego Garcia, Giorgia Conte, Eva M. Jimenez-Mateos, Beatrice D'Orsi, Amaya Sanz-Rodriguez, Jochen H.M. Prehn, David C. Henshall, Tobias Engel
    Journal of Neuroscience, 2019

RECENT SCHOLAR PUBLICATIONS

  • Corrigendum to “Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice”[Brain Behav. Immun. 120 (2024) 121–140]
    M Alves, B Gil, J Villegas-Salmerón, V Salari, R Martins-Ferreira, ...
    Brain, Behavior, and Immunity , 2025
    2025
  • P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice
    M Alves, L de Diego-Garcia, G Vegliante, O Moreno, B Gil, ...
    Theranostics 15 (4), 1399 , 2025
    2025
    Citations: 16
  • Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
    M Alves, B Gil, J Villegas-Salmerón, V Salari, R Martins-Ferreira, ...
    Brain, behavior, and immunity 120, 121-140 , 2024
    2024
    Citations: 37
  • The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice
    J Smith, A Menéndez Méndez, M Alves, A Parras, G Conte, ...
    British Journal of Pharmacology 180 (13), 1710-1729 , 2023
    2023
    Citations: 30
  • The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following neonatal hypoxia in mice
    J Smith, AM Mendez, M Alves, A Parras, G Conte, A Bhattacharya, ...
    Authorea Preprints , 2022
    2022
    Citations: 1
  • Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice
    E Beamer, J Morgan, M Alves, A Menendez Mendez, G Morris, B Zimmer, ...
    British Journal of Pharmacology 179 (12), 2986-3006 , 2022
    2022
    Citations: 44
  • Identification of the P2X7 receptor signature in the brain and in the blood following seizures and during epilepsy
    G Conte
    Royal College of Surgeons in Ireland , 2021
    2021
  • The ATP-gated P2X7 receptor contributes to the development of drug-resistant status epilepticus in mice
    E Beamer, J Morgan, M Alves, AM Mendez, G Morris, B Zimmer, G Conte, ...
    authorea , 2021
    2021
  • Circulating P2X7 receptor signaling components as diagnostic biomarkers for temporal lobe epilepsy
    G Conte, A Menéndez-Méndez, S Bauer, H El-Naggar, M Alves, A Nicke, ...
    Cells 10 (9), 2444 , 2021
    2021
    Citations: 36
  • Elevated blood purine levels as a biomarker of seizures and epilepsy
    E Beamer, A Lacey, M Alves, G Conte, F Tian, L de Diego‐Garcia, ...
    Epilepsia 62 (3), 817-828 , 2021
    2021
    Citations: 41
  • High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsy
    G Conte, A Parras, M Alves, I Ollà, L De Diego‐Garcia, E Beamer, ...
    Epilepsia 61 (12), 2795-2810 , 2020
    2020
    Citations: 46
  • Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model
    A Ramirez-Fernandez, L Urbina-Trevino, G Conte, M Alves, B Rissiek, ...
    Scientific Reports 10 (1), 19876 , 2020
    2020
    Citations: 29
  • Characterization of the expression of the ATP-gated P2X7 receptor following status epilepticus and during epilepsy using a P2X7-EGFP reporter mouse
    J Morgan, M Alves, G Conte, A Menendez-Mendez, L de Diego-Garcia, ...
    Neuroscience Bulletin 36 (11), 1242-1258 , 2020
    2020
    Citations: 61
  • P2X7 receptor-dependent microRNA expression profile in the brain following status epilepticus in mice
    G Conte, NT Nguyen, M Alves, L de Diego-Garcia, A Kenny, A Nicke, ...
    Frontiers in Molecular Neuroscience 13, 127 , 2020
    2020
    Citations: 17
  • Large-scale changes to mRNA polyadenylation in temporal lobe epilepsy
    A Parras Rodriguez, L De Diego Garcia, M Alves, E Beamer, G Conte, ...
    Royal College of Surgeons in Ireland , 2020
    2020
  • Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy
    A Parras, L de Diego-Garcia, M Alves, E Beamer, G Conte, ...
    Brain 143 (7), 2139-2153 , 2020
    2020
    Citations: 28
  • High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsy
    G Conte, A Parras, M Alves, I Ollà, L de Diego-Garcia, E Beamer, ...
    bioRxiv, 2020.05. 12.092338 , 2020
    2020
  • Comparative analysis of two bac-transgenic P2X7 reporter mouse models reveals highly divergent EGFP exression patterns
    A Ramirez-Fernandez, G Conte, R Kopp, N Scalbert, B Rissiek, T Engel, ...
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 393 (SUPPL 1), 38-38 , 2020
    2020
  • ATP release during seizures–A critical evaluation of the evidence
    E Beamer, G Conte, T Engel
    Brain Research Bulletin 151, 65-73 , 2019
    2019
    Citations: 68
  • Large-scale changes to mRNA polyadenylation in temporal lobe epilepsy
    A Parras, L de Diego-Garcia, M Alves, E Beamer, G Conte, J Morgan, ...
    bioRxiv, 725325 , 2019
    2019

MOST CITED SCHOLAR PUBLICATIONS

  • ATP release during seizures–A critical evaluation of the evidence
    E Beamer, G Conte, T Engel
    Brain Research Bulletin 151, 65-73 , 2019
    2019
    Citations: 68
  • Characterization of the expression of the ATP-gated P2X7 receptor following status epilepticus and during epilepsy using a P2X7-EGFP reporter mouse
    J Morgan, M Alves, G Conte, A Menendez-Mendez, L de Diego-Garcia, ...
    Neuroscience Bulletin 36 (11), 1242-1258 , 2020
    2020
    Citations: 61
  • Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y 1 Receptor in Experimental Epilepsy
    M Alves, L De Diego Garcia, G Conte, EM Jimenez-Mateos, B D'Orsi, ...
    The Journal of Neuroscience 39 (27), 5377-5392 , 2019
    2019
    Citations: 50
  • High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsy
    G Conte, A Parras, M Alves, I Ollà, L De Diego‐Garcia, E Beamer, ...
    Epilepsia 61 (12), 2795-2810 , 2020
    2020
    Citations: 46
  • Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice
    E Beamer, J Morgan, M Alves, A Menendez Mendez, G Morris, B Zimmer, ...
    British Journal of Pharmacology 179 (12), 2986-3006 , 2022
    2022
    Citations: 44
  • Elevated blood purine levels as a biomarker of seizures and epilepsy
    E Beamer, A Lacey, M Alves, G Conte, F Tian, L de Diego‐Garcia, ...
    Epilepsia 62 (3), 817-828 , 2021
    2021
    Citations: 41
  • Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
    M Alves, B Gil, J Villegas-Salmerón, V Salari, R Martins-Ferreira, ...
    Brain, behavior, and immunity 120, 121-140 , 2024
    2024
    Citations: 37
  • Circulating P2X7 receptor signaling components as diagnostic biomarkers for temporal lobe epilepsy
    G Conte, A Menéndez-Méndez, S Bauer, H El-Naggar, M Alves, A Nicke, ...
    Cells 10 (9), 2444 , 2021
    2021
    Citations: 36
  • The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice
    J Smith, A Menéndez Méndez, M Alves, A Parras, G Conte, ...
    British Journal of Pharmacology 180 (13), 1710-1729 , 2023
    2023
    Citations: 30
  • Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model
    A Ramirez-Fernandez, L Urbina-Trevino, G Conte, M Alves, B Rissiek, ...
    Scientific Reports 10 (1), 19876 , 2020
    2020
    Citations: 29
  • Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy
    A Parras, L de Diego-Garcia, M Alves, E Beamer, G Conte, ...
    Brain 143 (7), 2139-2153 , 2020
    2020
    Citations: 28
  • P2X7 receptor-dependent microRNA expression profile in the brain following status epilepticus in mice
    G Conte, NT Nguyen, M Alves, L de Diego-Garcia, A Kenny, A Nicke, ...
    Frontiers in Molecular Neuroscience 13, 127 , 2020
    2020
    Citations: 17
  • P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice
    M Alves, L de Diego-Garcia, G Vegliante, O Moreno, B Gil, ...
    Theranostics 15 (4), 1399 , 2025
    2025
    Citations: 16
  • On the mechanism of the electrophysiological changes and membrane lesions induced by asbestos fiber exposure in Xenopus laevis oocytes
    A Bernareggi, G Conte, A Constanti, V Borelli, F Vita, G Zabucchi
    Scientific Reports 9 (1), 2014 , 2019
    2019
    Citations: 8
  • The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following neonatal hypoxia in mice
    J Smith, AM Mendez, M Alves, A Parras, G Conte, A Bhattacharya, ...
    Authorea Preprints , 2022
    2022
    Citations: 1
  • Corrigendum to “Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice”[Brain Behav. Immun. 120 (2024) 121–140]
    M Alves, B Gil, J Villegas-Salmerón, V Salari, R Martins-Ferreira, ...
    Brain, Behavior, and Immunity , 2025
    2025
  • Identification of the P2X7 receptor signature in the brain and in the blood following seizures and during epilepsy
    G Conte
    Royal College of Surgeons in Ireland , 2021
    2021
  • The ATP-gated P2X7 receptor contributes to the development of drug-resistant status epilepticus in mice
    E Beamer, J Morgan, M Alves, AM Mendez, G Morris, B Zimmer, G Conte, ...
    authorea , 2021
    2021
  • Large-scale changes to mRNA polyadenylation in temporal lobe epilepsy
    A Parras Rodriguez, L De Diego Garcia, M Alves, E Beamer, G Conte, ...
    Royal College of Surgeons in Ireland , 2020
    2020
  • High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsy
    G Conte, A Parras, M Alves, I Ollà, L de Diego-Garcia, E Beamer, ...
    bioRxiv, 2020.05. 12.092338 , 2020
    2020