Rahul completed his Ph.D. from IIT Gandhinagar under supervision of Dr. Sriram Kanvah. His doctoral research includes synthesis of functional sensors of important analytes and imaging agents of cellular organelle. After completion of doctoral research, he joined Jay Chemicals as a research associate where his research focusses on development of methodology for synthesis of fine and speciality chemicals.
EDUCATION
Doctor of Philosophy in Chemistry (2018-2023)
Institute - Indian Institute of Technology Gandhinagar
Supervisor - Dr Sriram Kanvah
Thesis Title - "Functional Cyanostilbenes: Sensing to Imaging"
Master in Science (Organic Chemistry) (2015-2017)
Institute - Department of Chemistry, Savitribai Phule Pune University (Formerly University of Pune)
Thesis Supervisor - Prof. Dilip D Dhavale
Thesis Title - " Synthesis of Pancratistatin Analogues Intermediates"
Bachelor of Science
Institute - G.S. College, Khamgaon, Affiliated to Sant Gadge Baba Amravati University
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Biochemistry, Chemistry
8
Scopus Publications
129
Scholar Citations
6
Scholar h-index
5
Scholar i10-index
Scopus Publications
Functional α-Cyanostilbenes: Sensing to Imaging Sriram Kanvah, Rahul Dahiwadkar, Masood A. Kaloo Synlett, 2023 In recent years, there has been considerable interest in cyanostilbenes due to their unique photophysical properties. The compounds emit light when aggregating, commonly called aggregation-induced emission (AIE). This remarkable feature makes cyanostilbenes ideal for various sensing applications, especially in aqueous environments. The detection of various analytes, such as metal ions and nitroaromatic compounds, has been accomplished using these compounds through various sensing mechanisms from chelation-enhanced fluorescence to fluorescence quenching. Furthermore, cyanostilbenes have shown great promise in biological imaging applications and have been employed for intracellular imaging, tracking, and targeting of sub-cellular organelles. The development and utilization of cyanostilbenes can significantly impact advanced sensing and imaging technologies in both analytical and biological fields. This potential stems from the unique properties of cyanostilbenes, such as their AIE characteristics, which sets them apart from other compounds and makes them highly useful for various applications. Further exploration and development of cyanostilbenes could lead to the creation of novel sensing and imaging technologies with wide-ranging applications in both academic and industrial settings.
Plasmon-Rich BCZT Nanoparticles in the Photonic Crystal-Coupled Emission Platform for Cavity Hotspot-Driven Attomolar Sensing Sudha Maria Lis S, Seemesh Bhaskar, Rahul Dahiwadkar, Sriram Kanvah, Sai Sathish Ramamurthy, Shivakiran Bhaktha B. N ACS Applied Nano Materials, 2023 The unique functionality of metallic and dielectric nanomaterials to generate intense electromagnetic field localization termed “hotspots” has been exploited in numerous luminescence-based biosensing applications. To obtain an amplified, sharply directional, and polarized emission, tunable size and shape morphologies have been evaluated in the surface plasmon-coupled emission (SPCE) platform. Although such studies have significantly facilitated the biosensor modalities, inevitable parasitic Ohmic losses in metal-dependent SPCE platforms have remained a significant bottleneck. In this context, recently, a dielectric-based photonic crystal-coupled emission (PCCE) platform is being explored for point-of-care diagnostics as it facilitates overcoming the limitations of conventional fluorescence and SPCE technologies. However, despite the utility of myriad metallo-dielectric hybrid nanoarchitectures and interfaces in SPCE and PCCE platforms to augment the photoplasmonic coupling efficiency, the expected fluorescence intensity remains compromised due to the presence of metallic components. In this background, we demonstrate the utility of high refractive index (HRI), ferroelectric, and biocompatible perovskite Ba 0.85 Ca 0.15 Zr 0.1 Ti 0.9 O 3 (BCZT) nanoparticles (NPs) for significantly augmenting the fluorescence of fluorophores. While nano-BCZT yielded 100-fold fluorescence enhancement in the lossy SPCE platform, >1000-fold enhancement is demonstrated in the lossless PCCE platform due to the generation of multifold nanocavities with copious hotspots. The localized density of states of radiating dipoles is maximized with effective coherent and collective photon coupling in a highly desirable nano-BCZT, graphene oxide, and one-dimensional photonic crystal ensemble. Consequently, this state-of-the-art ensemble presents an unaccustomed enhancement due to the judicious synergy of all-dielectric HRI NPs, π-plasmons, and internal optical modes which have been utilized for sensing a weakly fluorescent TPYP3 molecule at attomolar limit of detection. This all-dielectric-based PCCE platform opens up possibilities of using fluorophores with low quantum yield for sensing purposes. The sustainable nanoengineering technique developed here for photoplasmonic application opens opportunities for investigating such next-generation all-dielectric metasurfaces for point-of-care diagnostics and biosensing.
Halogen-bonded co-crystals with AIE-active α-cyanostilbenes Rahul Dahiwadkar, Gurudutt Dubey, Althaf Shaik, Palash Jana, Vijay Thiruvenkatam, Sriram Kanvah New Journal of Chemistry, 2023 A cooperative co-crystal and co-gels were obtained from combining two different aggregation-induced emitting cyanostilbene units through halogen bonding interaction.
AIE active cyanostilbenes for live-cell imaging of lipid droplets Rahul Dahiwadkar, Deeksha Rajput, Deepmala Singh, Virupakshi Soppina, Sriram Kanvah New Journal of Chemistry, 2023 Trifluoromethyl-substituted fluorophores with naphthalene and julolidine groups were utilized imaging and quantifying lipid droplets in COS-7 cells.
White light emission from AIE-active luminescent organic materials Beena Kumari, Rahul Dahiwadkar, Sriram Kanvah Aggregate, 2022 Fluorescent organic materials that exhibit unique aggregation‐induced emission have been utilized for various applications, including white light emission (WLE). The materials typically rely on composite designs involving a mixture of compounds emitting at different wavelengths of light. To overcome the limitations offered by the design of such composite mixtures, tremendous efforts were also emphasized in developing single‐molecule substrates that emit white light. The white light by either method is typically controlled by the solvent polarity, energy and charge transfer, host‐guest interactions, gelation, or embedding in the polymer or organic frameworks. This article briefly reviews various molecules exhibiting aggregation‐induced emission behavior and emitting white light.
One- and Two-Component Organogels Containing Cyanostilbene without any Auxiliary Substituents Jagadish Katla, Althaf Shaik, Rahul Dahiwadkar, Vijay Thiruvenkatam, Sriram Kanvah Chempluschem, 2019 Pyridyl acrylonitrile without traditional auxiliary groups form stable organogels in ethanol. The addition of a second non‐gelating cyanostilbene component results in a more stable two‐component gel. Single crystal X‐ray data reveal the influence of C−H⋅ ⋅ ⋅N, C−H⋅ ⋅ ⋅π, and π–π interactions in the formation of organogels. The morphology of the xerogels was studied by using SEM, which showed the self‐assembly of molecules to fibers and sheet‐like structures, and phase differences upon the gel formation and the structural phase characterization was measured using powder XRD. Exposure of the organogels to acidic (TFA) vapors results in distinct color changes and loss of gelation properties, thus highlighting the potential of these gels in sensing. The results represent a rare example of two‐component organogels using two different cyanostilbene units and show that functional two‐component organogels can be formed by utilizing the synergistic effects of the individual components.
RECENT SCHOLAR PUBLICATIONS
Functional α-Cyanostilbenes: Sensing to Imaging R Dahiwadkar, MA Kaloo, S Kanvah Synlett 35 (01), 3-20 , 2024 2024.0 Citations: 1
Halogen-bonded co-crystals with AIE active?-cyanostilbenes R Dahiwadkar, G Dubey, A Shaik, P Jana, V Thiruvenkatam, S Kanvah Royal Society of Chemistry , 2023 2023.0
Functional organogel with α-cyanostilbene scaffold: aggregation enhanced emission and picric acid sensing R Dahiwadkar, A Murugan, D Johnson, R Chakraborty, V Thiruvenkatam, ... Journal of Photochemistry and Photobiology A: Chemistry 434, 114227 , 2023 2023.0 Citations: 13
Halogen-bonded co-crystals with AIE-active α-cyanostilbenes R Dahiwadkar, G Dubey, A Shaik, P Jana, V Thiruvenkatam, S Kanvah New Journal of Chemistry 47 (24), 11685-11696 , 2023 2023.0 Citations: 1
AIE active cyanostilbenes for live-cell imaging of lipid droplets R Dahiwadkar, D Rajput, D Singh, V Soppina, S Kanvah New Journal of Chemistry 47 (21), 10016-10024 , 2023 2023.0 Citations: 9
White light emission from AIE‐active luminescent organic materials B Kumari, R Dahiwadkar, S Kanvah Aggregate 3 (5), e191 , 2022 2022.0 Citations: 54
Detection of illicit GHB using AIE active fluorene containing α-Cyanostilbenes R Dahiwadkar, H Kumar, S Kanvah Journal of Photochemistry and Photobiology A: Chemistry 427, 113844 , 2022 2022.0 Citations: 24
Detection of Illicit GHB using AIE active fluorene containing?-cyanostilbenes R Dahiwadkar, H Kumar, S Kanvah Elsevier , 2022 2022.0
Sensitive detection of sedatives using fluorescent probes R Dahiwadkar, S Kanvah Proceedings of the sixteenth DAE-BRNS biennial Trombay symposium on … , 2022 2022.0
Styryl pyridinium fluorescence probes for staining nucleus R Dahiwadkar, A Rajwar, S Kharbanda, D Bhatia, S Kanvah 2020.0
One‐and Two‐Component Organogels Containing Cyanostilbene without any Auxiliary Substituents J Katla, A Shaik, R Dahiwadkar, V Thiruvenkatam, S Kanvah ChemPlusChem 84 (12), 1789-1795 , 2019 2019.0 Citations: 13
Self-assembling, red-emitting pyridinium based cationic probes targeting nucleus and plasma membrane in mammalian cells R Dahiwadkar, S Kanvah, S Kharbanda, A Rajwar, D Bhatia Proceedings of the fifteenth DAE-BRNS biennial Trombay symposium on … , 2019 2019.0
One and two? component organogels with cyanostilbene without any auxiliary substituents J Katla, A Shaik, R Dahiwadkar, V Thiruvenkatam, S Kanvah Wiley , 2019 2019.0
Synthesis and evaluation of stilbene derivatives for protein binding R Dahiwadkar, S Kanvah
MOST CITED SCHOLAR PUBLICATIONS
White light emission from AIE‐active luminescent organic materials B Kumari, R Dahiwadkar, S Kanvah Aggregate 3 (5), e191 , 2022 2022.0 Citations: 54
Detection of illicit GHB using AIE active fluorene containing α-Cyanostilbenes R Dahiwadkar, H Kumar, S Kanvah Journal of Photochemistry and Photobiology A: Chemistry 427, 113844 , 2022 2022.0 Citations: 24
Functional organogel with α-cyanostilbene scaffold: aggregation enhanced emission and picric acid sensing R Dahiwadkar, A Murugan, D Johnson, R Chakraborty, V Thiruvenkatam, ... Journal of Photochemistry and Photobiology A: Chemistry 434, 114227 , 2023 2023.0 Citations: 13
One‐and Two‐Component Organogels Containing Cyanostilbene without any Auxiliary Substituents J Katla, A Shaik, R Dahiwadkar, V Thiruvenkatam, S Kanvah ChemPlusChem 84 (12), 1789-1795 , 2019 2019.0 Citations: 13
AIE active cyanostilbenes for live-cell imaging of lipid droplets R Dahiwadkar, D Rajput, D Singh, V Soppina, S Kanvah New Journal of Chemistry 47 (21), 10016-10024 , 2023 2023.0 Citations: 9
Functional α-Cyanostilbenes: Sensing to Imaging R Dahiwadkar, MA Kaloo, S Kanvah Synlett 35 (01), 3-20 , 2024 2024.0 Citations: 1
Halogen-bonded co-crystals with AIE-active α-cyanostilbenes R Dahiwadkar, G Dubey, A Shaik, P Jana, V Thiruvenkatam, S Kanvah New Journal of Chemistry 47 (24), 11685-11696 , 2023 2023.0 Citations: 1
Halogen-bonded co-crystals with AIE active?-cyanostilbenes R Dahiwadkar, G Dubey, A Shaik, P Jana, V Thiruvenkatam, S Kanvah Royal Society of Chemistry , 2023 2023.0
Detection of Illicit GHB using AIE active fluorene containing?-cyanostilbenes R Dahiwadkar, H Kumar, S Kanvah Elsevier , 2022 2022.0
Sensitive detection of sedatives using fluorescent probes R Dahiwadkar, S Kanvah Proceedings of the sixteenth DAE-BRNS biennial Trombay symposium on … , 2022 2022.0
Styryl pyridinium fluorescence probes for staining nucleus R Dahiwadkar, A Rajwar, S Kharbanda, D Bhatia, S Kanvah 2020.0
Self-assembling, red-emitting pyridinium based cationic probes targeting nucleus and plasma membrane in mammalian cells R Dahiwadkar, S Kanvah, S Kharbanda, A Rajwar, D Bhatia Proceedings of the fifteenth DAE-BRNS biennial Trombay symposium on … , 2019 2019.0
One and two? component organogels with cyanostilbene without any auxiliary substituents J Katla, A Shaik, R Dahiwadkar, V Thiruvenkatam, S Kanvah Wiley , 2019 2019.0
Synthesis and evaluation of stilbene derivatives for protein binding R Dahiwadkar, S Kanvah
