Moataz Ahmed Ibrahim Shaldam

Scopus Publications

Antifungal activity of oily core PEGylated PLGA nanocapsules loaded with Penicillium oxalicum fungal extract: in vitro, in vivo, and in silico study
Engy Elekhnawy, Dalia H. Abdelkader, Duaa Eliwa, Sarah Ibrahim, Moataz A. Shaldam, et al.
Microbial Cell Factories, 2026
The rise of difficult-to-treat fungal infections necessitates novel therapeutic strategies. In this study, endophytic fungi were isolated from Acalypha hispida leaves and molecularly identified as Penicillium oxalicum via 18S rRNA sequencing. LC–MS/MS analysis of the fungal extract revealed major bioactive compounds, including linoleic acid, sinapinic acid, alternariol monomethyl ether, ellagic acid, and kaurenic acid. Oily-core poly (ethylene glycol) methyl ether-block-poly(lactide- co -glycolide) nanocapsules (PEGylated PLGA NCs) were developed to encapsulate the fungal extract, improving stability and bioavailability. The PEGylated PLGA NCs exhibited controlled particle size, positive surface charge, and spherical morphology. In vitro, the PEGylated PLGA NCs demonstrated antifungal activity against Candida albicans with inhibition zones of 10–14 mm. In vivo, treatment significantly improved histological features of the kidney, liver, and spleen, and reduced tumor necrosis factor-alpha and cyclooxygenase-2 expression. In silico studies further confirmed the potential of the major compounds of the fungal extract to inhibit C. albicans aspartic proteinases SAP4-6. These findings suggest that PEGylated PLGA NCs loaded with P. oxalicum extract represent a promising antifungal therapeutic strategy.
Exploring the impact of the innovative compound 3-(3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5-(pyridin-3-yl)-1H-pyrazol-1-yl) indolin-2-one on accelerating wound recovery
Ahmed Sabt, Heba Abdelmegeed, Abdel-Razik H. Abdel-Razik, Mohamed G. Thabit, Marwa Balaha, et al.
Scientific Reports, 2026
Isatin-triazole/imidazole hybrids as dual CDK2/VEGFR2 inhibitors with potent anti-cancer activity: design, synthesis, and biological evaluations
Zainab M. Elsayed, Marwa Balaha, Haytham O. Tawfik, Eman F. Khaleel, Moataz A. Shaldam, et al.
Bioorganic Chemistry, 2026
Design, synthesis, in vitro, and in silico evaluation of multi-functionalized pyrimidines as potential multitarget-directed anti-inflammatory agents
Asmaa Essam, Nermine A. Osman, Moataz A. Shaldam, Hanan A. Abdel-Fattah, Amany M. Ghanim
Bioorganic Chemistry, 2026
Biphenyl urea derivatives as novel GPX4 inhibitors: ferroptosis-mediated antiproliferative activity against CNS cancer cells
Wagdy M. Eldehna, Salma M. Hefny, Heba A. Elsebaie, Heba Aref, Anwar A. El-Hamaky, et al.
Bioorganic Chemistry, 2026
Molecular Boomerangs Against Cancer: Design, Synthesis, Biological Evaluation, and In Silico Study of Novel Dual PARP-1/EGFR Inhibitors
Haytham O. Tawfik, Amr Tayel, Salma M. Hefny, Tarfah Al‐Warhi, Nada K. Sedky, et al.
Drug Development Research, 2026
A possible method for improving anti‐cancer efficacy is the combination of the inhibition of epidermal growth factor receptor (EGFR) and poly (ADP‐ribose) polymerase‐1 (PARP‐1). This work describes the rational design, synthesis, and complete characterization of a novel class of boomerang‐shaped dual PARP‐1/EGFR inhibitors ( 3a – o ). HepG‐2 and MDA‐MB‐231 cancer cell lines were used to test the synthesized compounds’ antiproliferative potential; MDA‐MB‐231 cells showed greater sensitivity. Compounds 3h , 3i , and 3j had the strongest cytotoxic effects among the series, with IC 50 values of 0.23, 0.90, and 1.40 µM, respectively, against MDA‐MB‐231 cells. Compared with the reference medications erlotinib and olaparib, compound 3h showed the highest dual inhibition (EGFR IC 50 = 1.62 µM and PARP‐1 IC 50 = 0.36 µM) in enzymatic experiments, demonstrating that these compounds effectively inhibited both EGFR and PARP‐1. Compound 3h strongly promoted apoptosis in MDA‐MB‐231 cells, increasing the total apoptotic population to 20.04% and causing G1‐phase cell‐cycle arrest, as determined by mechanistic studies. In vivo tumor growth inhibition trials showed a tumor inhibition rate (TIR%) of 41.4% for compound 3h compared to 48.8% for doxorubicin (DOX). Liver function biomarkers and hematological parameters remained within the acceptable levels following compound 3h treatment. The dual‐target activity of compound 3h was further validated by molecular docking and molecular dynamics simulations, which demonstrated persistent binding contacts within the active sites of PARP‐1 and EGFR.
Thiazole-Semicarbazone Hybrids as Dual-Stage Inhibitors of Leishmania major Growth: Design, Synthesis, and Mechanistic Insights
Moataz A. Shaldam, Haytham O. Tawfik, Abdelrahman I. Zain‐Alabdeen, Rehan Monir, Mohamed R. Elnagar, et al.
Drug Development Research, 2026
As a neglected tropical disease, Leishmaniasis continues to pose a serious threat to world health, especially in areas with limited resources. There is a pressing need for safer and more effective antileishmanial drugs due to the limited efficacy, toxicity, and rising resistance of available agents. We report the rational design, synthesis, and biological evaluation of a novel series of 15 hybrid compounds ( 3a‐o ), utilizing the thiazole and semicarbazone pharmacophores, two privileged scaffolds recognized for their wide range of biological activity. Both intracellular amastigote and promastigote forms of Leishmania major were used to test the synthesized compounds' antileishmanial potential. With IC₅₀ values ranging from 2.97 to 10.18 µM against promastigotes and from 3.47 to 12.36 µM against amastigotes, a number of compounds demonstrated greater activity than the reference medication miltefosine. Selectivity indices revealed that compounds 3c , 3d , 3h , and 3i were the most potent, exhibiting a desirable balance between efficacy and cytotoxicity. The robust binding affinities and consistent interactions of these lead compounds inside the PTR1 and DHFR active sites were further supported by in silico docking. In conclusion, this study presents a novel chemotype that shows great promise for future advancement as a potent and focused antileishmanial treatment.
Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti-Mycobacterium tuberculosis agents
Ahmed Sabt, Małgorzata Korycka-Machała, Asmaa F. Kassem, Abdulrahman M. Saleh, Hanaa Farag, et al.
Rsc Medicinal Chemistry, 2026
The updated guidelines from the World Health Organization highlight that treatment options for multidrug-resistant tuberculosis (MDR-TB) remain limited due to the scarcity of effective drugs.
Piperidine-based small molecules as dual-stage antileishmanial agents targeting parasite folate pathway
Tarfah Al-Warhi, Haytham O. Tawfik, Nermeen M. Rashad, Moataz A. Shaldam, Sherry N. Nasralla, et al.
Bioorganic Chemistry, 2026
Multistep structure-based virtual screening approach toward the identification of potential potent SARS-CoV-2 Mpro inhibitors
Taghreed A. Majrashi, Mahmoud A. El Hassab, Mohammed K. Abdel-Hamid Amin, Eslam B. Elkaeed, Moataz A. Shaldam, et al.
Journal of Biomolecular Structure and Dynamics, 2026
Patents involving monoamine oxidase (MAO): a comprehensive update (2022–2025) on its inhibitors and applications
Moataz A. Shaldam, Simone Carradori, Marwa Balaha, Paolo Guglielmi, Francesca Diomede, et al.
Expert Opinion on Therapeutic Patents, 2026
Potential of MAO-B Inhibitors with Multi-target Inhibition and Antioxidant Properties for the Treatment of Neurodegenerative Disorders
Moataz A. Shaldam, Simone Carradori, Francesco Melfi, Paolo Guglielmi, Francesca Diomede, et al.
Mini Reviews in Medicinal Chemistry, 2026
Targeting Helicobacter pylori enzymes using Viscum album L. extract: in silico molecular docking and in vitro study
Ioana Alexandra Cardos, Catalina Danila, Galal Yahya, Noura M. Seleem, Rasha A. Mosbah, et al.
Frontiers in Cellular and Infection Microbiology, 2026
Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity
Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Miroslav Peřina, Ahmed T. Negmeldin, et al.
Frontiers in Pharmacology, 2026
Employing diclofenac sodium as a novel therapeutic frontier for Staphylococcus epidermidis infections
Amal M. Abo-Kamar, Ahmed A. Abdelaziz, Alaa E. Ashour, Moataz A. Shaldam, Engy Elekhnawy
Scientific Reports, 2025
Identification of isatin-triazole-benzenesulfonamide hybrids as dual hCA IX/XII and c-met inhibitors with hypoxia-mediated chemo-sensitizing activity
Wagdy M. Eldehna, Mohamed R. Elnagar, Simone Giovannuzzi, Amr Tayel, Maha-Hamadien Abdulla, et al.
Bioorganic Chemistry, 2025
Development of New Pyrazolo [3,4-b]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity
Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Veronika Vojáčková, Ahmed T. Negmeldin, et al.
Pharmaceuticals, 2025
Correction: Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens (Microorganisms, (2021), 9, 5, (1083), 10.3390/microorganisms9051083)
Ahdab N. Khayyat, Wael A. H. Hegazy, Moataz A. Shaldam, Rasha Mosbah, Ahmad J. Almalki, et al.
Microorganisms, 2025
Exploring antitubercular activity of new coumarin derivatives targeting enoyl acyl carrier protein reductase (InhA): Synthesis, biological evaluation and computational studies
Manal S Ebaid, Małgorzata Korycka-Machala, Moataz A. Shaldam, Mohamed G. Thabit, Malwina Kawka, et al.
Journal of Molecular Structure, 2025
Protective effect of empagliflozin against paracetamol-induced acute kidney injury through modulation of AMPK/SIRT1/PGC-1α pathway in experimental mice
Esraa M. Mosalam, Hind S. AboShabaan, Marwa M. Mahfouz, Amany Said Sallam, Enas Elhosary, et al.
Toxicology and Applied Pharmacology, 2025
Antimicrobial and Anti-Efflux Machinery of FDA-Approved Proton Pump Inhibitors and Vitamins Against Klebsiella pneumoniae and Pseudomonas aeruginosa
Lekaa L. Lutfi, Moataz A. Shaldam, Mona I. Shaaban, Soha Lotfy Elshaer
Microorganisms, 2025
Targeted synthesis of a trimethoxyphenyltetrahydropyrimidine analogue designed as a DNA intercalator: in silico, multi-spectroscopic, thermodynamic, and in vitro approaches
Ahmed A. Al-Karmalawy, Ayman Abo Elmaaty, Galal Magdy, Aya Saad Radwan, Radwan Alnajjar, et al.
Rsc Advances, 2025
Discovery of 1-phenyl-1,2,3-triazole ureas as dual VEGFR-2/JNK-1 type II kinase inhibitors targeting pancreatic cancer
Wagdy M. Eldehna, Eslam Roshdy, Maha-Hamadien Abdulla, Abdelrahman I. Zain-Alabdeen, Moataz A. Shaldam, et al.
International Journal of Biological Macromolecules, 2025
Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors
Mohamed A. Zeidan, Mahmoud Abdelrahman Alkabbani, Simone Giovannuzzi, Eman F. Khaleel, Anwar A. El-Hamaky, et al.
Journal of Medicinal Chemistry, 2025
Mechanistic and Molecular Insights into Empagliflozin’s Role in Ferroptosis and Inflammation Trajectories in Acetaminophen-Induced Hepatotoxicity
Aisha Alhaddad, Esraa M. Mosalam, Hind S. AboShabaan, Amany Said Sallam, Marwa M. Mahfouz, et al.
Pharmaceuticals, 2025
Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: in vitro and in vivo studies
Ahmed A. Al-Karmalawy, Ahmed F. Mohamed, Heba Nasr Shalaby, Ayman Abo Elmaaty, Riham A. El-Shiekh, et al.
Rsc Medicinal Chemistry, 2025
Unlocking the potential of eggplant peel: Powerful peroxidase nanozyme for l-cysteine determination in pharmaceutical supplements
Eman A. Elshenawy, Moataz A. Shaldam
Microchemical Journal, 2024
Unveiling the antibacterial action of ambroxol against Staphylococcus aureus bacteria: in vitro, in vivo, and in silico investigation
Ahmed A. Abdelaziz, Amal M. Abo-Kamar, Alaa E. Ashour, Moataz A. Shaldam, Engy Elekhnawy
BMC Microbiology, 2024
Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations
Moataz A. Shaldam, Mai H.A. Mousa, Haytham O. Tawfik, Ahmed M. El-Dessouki, Marwa Sharaky, et al.
Bioorganic Chemistry, 2024
Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights
Wagdy M. Eldehna, Haytham O. Tawfik, Maha-Hamadien Abdulla, Mohamed S. Nafie, Heba Aref, et al.
Bioorganic Chemistry, 2024
Discovery of new quinoline derivatives bearing 1-aryl-1,2,3-triazole motif as influenza H1N1 virus neuraminidase inhibitors
Ahmed Sabt, Eman F. Khaleel, Moataz A. Shaldam, Manal S. Ebaid, Rehab Mustafa Badi, et al.
Bioorganic Chemistry, 2024
Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments
Heba A. Elsebaie, Maha-Hamadien Abdulla, Zainab M. Elsayed, Moataz A. Shaldam, Haytham O. Tawfik, et al.
Bioorganic Chemistry, 2024
Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents
Bassem H. Naguib, Heba A. Elsebaie, Mohamed S. Nafie, Samy Mohamady, Nader R. Albujuq, et al.
Bioorganic Chemistry, 2024
Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity
Tarfah Al-Warhi, Ahmed Sabt, Małgorzata Korycka-Machala, Asmaa F. Kassem, Moataz A. Shaldam, et al.
Rsc Advances, 2024
New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling
Asmaa F. Kassem, Ahmed Sabt, Małgorzata Korycka-Machala, Moataz A. Shaldam, Malwina Kawka, et al.
Bioorganic Chemistry, 2024
Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations
Moataz A. Shaldam, Maha-Hamadien Abdulla, Andrea Angeli, Salma M. Hefny, Eman M. El-labbad, et al.
Journal of Molecular Structure, 2024
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments
Salma M. Hefny, Tarek F. El-Moselhy, Nabaweya El-Din, Andrea Ammara, Andrea Angeli, et al.
European Journal of Medicinal Chemistry, 2024
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies
Heba A. Elsebaie, Mohamed S. Nafie, Haytham O. Tawfik, Amany Belal, Mohammed M. Ghoneim, et al.
Rsc Medicinal Chemistry, 2024
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles
Salma M. Hefny, Tarek F. El-Moselhy, Nabaweya El-Din, Simone Giovannuzzi, Thamer Bin Traiki, et al.
Journal of Medicinal Chemistry, 2024
DFT and molecular simulation validation of the binding activity of PDEδ inhibitors for repression of oncogenic k-Ras
Taghreed A. Majrashi, Ahmed Sabt, Hadia Almahli, Mahmoud A. El Hassab, Mahmoud A. Noamaan, et al.
Plos One, 2024
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study
Samy Mohamady, Ahmed F. Khalil, Bassem H. Naguib, Mohamed S. Nafie, Haytham O. Tawfik, et al.
Bioorganic Chemistry, 2024
Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities
Heba A. Elsebaie, Tarek F. El-Moselhy, Eman A. El-Bastawissy, Kamel M. Elberembally, Rehab Mustafa Badi, et al.
Bioorganic Chemistry, 2024
Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin
Hebatallah M. Saad, Engy Elekhnawy, Moataz A. Shaldam, Moneerah J. Alqahtani, Najla Altwaijry, et al.
Biomedicine and Pharmacotherapy, 2024
Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma
Haytham O. Tawfik, Mohamed M. Saleh, Andrea Ammara, Eman F. Khaleel, Rehab Badi, et al.
Journal of Medicinal Chemistry, 2024
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments
Ahmed A. Al-Karmalawy, Mai H. A. Mousa, Marwa Sharaky, Mai A. E. Mourad, Ahmed M. El-Dessouki, et al.
Journal of Medicinal Chemistry, 2024
Study of the binding interaction of salmon sperm DNA with nintedanib, a tyrosine kinase inhibitor using multi-spectroscopic, thermodynamic, and in silico approaches
Aya Saad Radwan, Mohamed M. Salim, Mahmoud M. Elkhoudary, Ghada M. Hadad, Moataz A. Shaldam, et al.
Journal of Biomolecular Structure and Dynamics, 2024
Identification of 3-(5-cyano-6-oxo-pyridin-2-yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity
Moataz A. Shaldam, Ahmed F. Khalil, Hadia Almahli, Maiy Y. Jaballah, Andrea Angeli, et al.
Archiv Der Pharmazie, 2024
Metolazone co-crystals-loaded oral fast dissolving films: Design, optimization, and in vivo evaluation
Mohamed S. Mohamed, Ahmed A. El-Shenawy, Abd El hakim Ramadan, Essam A. Mahmoud, Mohammed A. Amin, et al.
Journal of Drug Delivery Science and Technology, 2023
Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments
Ahmed A. Al-Karmalawy, Mahmoud Rashed, Marwa Sharaky, Hamada S. Abulkhair, Mohamed M. Hammouda, et al.
European Journal of Medicinal Chemistry, 2023
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
Samaa Saied, Moataz Shaldam, Mostafa M. Elbadawi, Simone Giovannuzzi, Alessio Nocentini, et al.
European Journal of Medicinal Chemistry, 2023
Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights
Heba A. Elsebaie, Eman A. El-Bastawissy, Kamel M. Elberembally, Eman F. Khaleel, Rehab Mustafa Badi, et al.
Bioorganic Chemistry, 2023
2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling
Moataz A. Shaldam, Denisa Hendrychová, Radwan El-Haggar, Veronika Vojáčková, Taghreed A. Majrashi, et al.
European Journal of Medicinal Chemistry, 2023
1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities
Ahmed E. Elsawi, Mostafa M. Elbadawi, Alessio Nocentini, Hadia Almahli, Simone Giovannuzzi, et al.
Journal of Medicinal Chemistry, 2023
Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies
Ahmed H.E. Hassan, Kazem Mahmoud, Trong-Nhat Phan, Moataz A. Shaldam, Chae Hyeon Lee, et al.
European Journal of Medicinal Chemistry, 2023
Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect
Nashwah G. M. Attallah, Amal Kabbash, Walaa A. Negm, Engy Elekhnawy, Reem Binsuwaidan, et al.
Pharmaceuticals, 2023
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with in Vitro and in Vivo Evaluations
Ahmed A. Al-Karmalawy, Mohamed S. Nafie, Moataz A. Shaldam, Ayman Abo Elmaaty, Samar A. Antar, et al.
Journal of Medicinal Chemistry, 2023
Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent
Moataz Shaldam, Haytham Tawfik, Heba Elmansi, Fathalla Belal, Koki Yamaguchi, et al.
Journal of Biomolecular Structure and Dynamics, 2023
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
Moataz A. Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F. Khaleel, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Multi-spectroscopic, thermodynamic, and molecular docking/dynamic approaches for characterization of the binding interaction between calf thymus DNA and palbociclib
Galal Magdy, Moataz A. Shaldam, Fathalla Belal, Heba Elmansi
Scientific Reports, 2022
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition
Shaimaa M. Aboukhatwa, Amera O. Ibrahim, Hiroshi Aoyama, Ahmed S. Al-Behery, Moataz A. Shaldam, et al.
Bioorganic Chemistry, 2022
Chronotherapeutic neuroprotective effect of verapamil against lipopolysaccharide-induced neuroinflammation in mice through modulation of calcium-dependent genes
Esraa M. Mosalam, Aya Ibrahim Elberri, Amany Said Sallam, Heba Rady Salem, Ebtehal M. Metwally, et al.
Molecular Medicine, 2022
Ketoprofen, piroxicam and indomethacin-suppressed quorum sensing and virulence factors in Acinetobacter baumannii
Soha Lotfy Elshaer, Moataz A. Shaldam, Mona I. Shaaban
Journal of Applied Microbiology, 2022
Bilosomes as Nanoplatform for Oral Delivery and Modulated In Vivo Antimicrobial Activity of Lycopene
Reem Binsuwaidan, Amal A. Sultan, Walaa A. Negm, Nashwah G. M. Attallah, Moneerah J. Alqahtani, et al.
Pharmaceuticals, 2022
Anti-Biofilm and Antibacterial Activities of Cycas media R. Br Secondary Metabolites: In Silico, In Vitro, and In Vivo Approaches
Nashwah G. M. Attallah, Omnia Momtaz Al-Fakhrany, Engy Elekhnawy, Ismail A. Hussein, Moataz A. Shaldam, et al.
Antibiotics, 2022
Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa
Maan T. Khayat, Tarek S. Ibrahim, Ahdab N. Khayyat, Majed Alharbi, Moataz A. Shaldam, et al.
Microorganisms, 2022
The promising anti-virulence activity of candesartan, domperidone, and miconazole on Staphylococcus aureus
Amira M. El-Ganiny, Amany I. Gad, Mona A. El-Sayed, Moataz A. Shaldam, Hisham A. Abbas
Brazilian Journal of Microbiology, 2022
New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies
Sara A. Darwish, Mohamed M. El-Kerdawy, Ahmad R. Elsheakh, Rehab S. Abdelrahman, Moataz A. Shaldam, et al.
Bioorganic Chemistry, 2022
Multi-Spectroscopic, thermodynamic and molecular dynamic simulation studies for investigation of interaction of dapagliflozin with bovine serum albumin
Mohamed A. Abdelaziz, Moataz Shaldam, Ramadan A. El-Domany, Fathalla Belal
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2022
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
Haytham O. Tawfik, Moataz A. Shaldam, Alessio Nocentini, Rofaida Salem, Hadia Almahli, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A novel use of allopurinol as a quorum-sensing inhibitor in pseudomonas aeruginosa
Ahmed Al Saqr, Mohammed F. Aldawsari, El-Sayed Khafagy, Moataz A. Shaldam, Wael A. H. Hegazy, et al.
Antibiotics, 2021
Secnidazole is a promising imidazole mitigator of serratia marcescens virulence
Ahdab N. Khayyat, Hisham A. Abbas, Maan T. Khayat, Moataz A. Shaldam, Momen Askoura, et al.
Microorganisms, 2021
Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors
Moataz Shaldam, Alessio Nocentini, Zainab M. Elsayed, Tamer M. Ibrahim, Rofaida Salem, et al.
International Journal of Molecular Sciences, 2021
Virtual Screening Attributes Male Biased COVID-19 Mortality to Predicted Antiviral Activity of Female Sex Hormones
Galal Yahya, Basem Mansour, Kristina Keuper, Moataz Shaldam, Ahmed M. El-Baz
Letters in Drug Design and Discovery, 2021
Could the analgesic drugs, paracetamol and indomethacin, function as quorum sensing inhibitors?
Noura M. Seleem, Hamada Atallah, Hemat K. Abd El Latif, Moataz A. Shaldam, Amira M. El-Ganiny
Microbial Pathogenesis, 2021
In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes
Moataz A. Shaldam, Galal Yahya, Nashwa H. Mohamed, Mohamed M. Abdel-Daim, Yahya Al Naggar
Environmental Science and Pollution Research, 2021
Tackling virulence of pseudomonas aeruginosa by the natural furanone sotolon
Mohammed Aldawsari, El-Sayed Khafagy, Ahmed Saqr, Ahmed Alalaiwe, Hisham Abbas, et al.
Antibiotics, 2021
Xylitol inhibits growth and blocks virulence in serratia marcescens
Ahdab Khayyat, Wael Hegazy, Moataz Shaldam, Rasha Mosbah, Ahmad Almalki, et al.
Microorganisms, 2021
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors
Moataz Shaldam, Wagdy M. Eldehna, Alessio Nocentini, Zainab M. Elsayed, Tamer M. Ibrahim, et al.
European Journal of Medicinal Chemistry, 2021
New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study
Sara T. Al-Rashood, Shymaa S. Elshahawy, Asmaa M. El-Qaias, Dina S. El-Behedy, Alshaimaa A. Hassanin, et al.
Bioorganic and Medicinal Chemistry Letters, 2020
Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections
Noura M. Seleem, Hemat K. Abd El Latif, Moataz A. Shaldam, Amira El-Ganiny
European Journal of Clinical Microbiology and Infectious Diseases, 2020
Curtailing Quorum Sensing in Pseudomonas aeruginosa by Sitagliptin
Hisham A. Abbas, Moutaz A. Shaldam, Dalia Eldamasi
Current Microbiology, 2020
Synthesis of imidazolidine-2,4-dione and 2-thioxoimidazolidin-4-one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa
Basant Mohamed, Zakaria K. Abdel‐Samii, Eatedal H. Abdel‐Aal, Hisham A. Abbas, Moataz A. Shaldam, et al.
Archiv Der Pharmazie, 2020
Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance
Mardia T. El Sayed, Alaadin E. Sarhan, Entsar Ahmed, Reham R. Khattab, Mohamed Elnaggar, et al.
Chemistryselect, 2020
Applying green analytical chemistry (GAC) for development of stability indicating HPLC method for determining clonazepam and its related substances in pharmaceutical formulations and calculating uncertainty
Ahmed Badr Eldin, Abdallah Shalaby, Mahmoud Samy Abdallah, Moataz Ahmed Shaldam, Mohamed Adel Abdallah
Arabian Journal of Chemistry, 2019
Synthesis and Antibacterial Evaluation of New2-Phenylbenzimidazole Derivatives
Omayma R. Saleh, Moataz A. Shaldum, Reham M. Goda, Ihsan A. Shehata, Mahmoud B. El‐Ashmawy
Chemistryselect, 2019
Glyceryl trinitrate blocks staphyloxanthin and biofilm formation in Staphylococcus aureus
Hisham A Abbas, Ahmed M Elsherbini, Moutaz A Shaldam
African Health Sciences, 2019
Simultaneous Determination of Formoterol Fumarate and Budesonide Epimers in Metered Dose Inhaler Using Ion-Pair Chromatography
Y A Salem, M A Shaldam, D T El-Sherbiny, D R El-Wasseef, S M El-Ashry
Journal of Chromatographic Science, 2017
Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa
Hisham A. Abbas, Ahmed M. Elsherbini, Moutaz A. Shaldam
African Health Sciences, 2017
Synthesis, evaluation of pharmacological activity, and molecular docking of 1,4-dihydropyridines as calcium antagonists
Moataz Ahmed Shaldam, Mervat Hamed El-Hamamsy, Dalia Osama Saleh, Tarek Fathy El-Moselhy
Chemical and Pharmaceutical Bulletin, 2016
Glyceryl trinitrate is a novel inhibitor of quorum sensing in Pseudomonas aeruginosa
Hisham A. Abbas, Moutaz A. Shaldam
African Health Sciences, 2016
Development & Optimization of anti-dandruff shampoo by modifying its rheological behavior
Journal of Applied Cosmetology, 2015

Moataz Ahmed Ibrahim Shaldam

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