Stefano Taddei was born in Pisa, Italy, in 1957. He attended the State University of Pisa, where he graduated in Medicine and Surgery in 1982 and specialized in Clinical Pharmacology in 1986.
Prof. Taddei is Professor of Internal Medicine. He works currently as the Director of the Hypertension Unit of the Department of Clinical and Experimental Medicine
Prof. Taddei is a Fellow of the European Society of Cardiology, the European, International and American Society of Hypertension, the European Society of Clinical Investigation, the High Blood Pressure Council of the American Heart Association, and of the Italian Society of Hypertension. He has been a councilor of the Italian Society of Hypertension (2007-2009).
He is a member of the Editorial Boards of Hypertension, Blood Pressure, Journal of Cardiovascular Pharmacology,Current Vascular Pharmacology, Current Hypertension Reviews, High Blood Pressure and Cardiovascular Prevention and Journal of American Society of Hypertension. He is an International Associated Editor of the European Heart Journal.
His main research area is local neuro-humoral control of peripheral vessels in primary and secondary forms of hypertension, with particular emphasis on the sympathetic nervous system, the renin-angiotensin system and the endothelium.
He is also interested in the assessment of target-organ damage in hypertension, including vascular and cardiac structural alterations and the clinical pharmacology of cardiovascular drugs.
Prof. Taddei has participated in numerous clinical studies and is the authors of more than 350 original papers, reviews and editorials in international scientific journals (H index: 64; Impact Factor : >2154).
RESEARCH INTERESTS
Vascular reactivity in hypertension and cardiovascular risk factors
464
Scopus Publications
Scopus Publications
Combined physical and cognitive training enhances telomere length in mild cognitive impairment patients Andrea Borghini, Paola Canale, Rosa Sicari, Nicoletta Berardi, Fabrizio d’Adda di Fagagna, Alessandro Sale, Maria Grazia Andreassi, Train the Brain Consortium, L. Maffei, E. Picano, A. Angelucci, F. Baldacci, L. Baroncelli, T. Begenisic, P. F. Bellinvia, L. Biagi, J. Bonaccorsi, E. Bonanni, U. Bonuccelli, C. Braschi, M. Broccardi, R. M. Bruno, M. Caleo, C. Carlesi, L. Carnicelli, G. Cartoni, L. Cecchetti, M. C. Cenni, R. Ceravolo, L. Chico, S. Cintoli, G. Cioni, M. Coscia, M. Costa, G. D’Angelo, P. D’Ascanio, M. De Nes, S. Del Turco, E. Di Coscio, M. Di Galante, N. di Lascio, F. Faita, I. Falorni, U. Faraguna, A. Fenu, L. Fortunato, R. Franco, L. Gargani, R. Gargiulo, L. Ghiadoni, F. S. Giorgi, R. Iannarella, C. Iofrida, C. Kusmic, F. Limongi, M. Maestri, M. Maffei, S. Maggi, M. Mainardi, L. Mammana, A. Marabotti, V. Mariotti, E. Melissari, A. Mercuri, S. Micera, S. Molinaro, R. Narducci, T. Navarra, M. Noale, C. Pagni, S. Palumbo, R. Pasquariello, S. Pellegrini, P. Pietrini, T. Pizzorusso, A. Poli, L. Pratali, A. Retico, E. Ricciardi, G. Rota, S. Sbrana, G. Scabia, M. Scali, D. Scelfo, G. Siciliano, F. Stea, S. Taddei, G. Tognoni, A. Tonacci, M. Tosetti, S. Turchi, L. Volpi BMC Geriatrics, 2026 Environmental enrichment training may delay cognitive decline in mild cognitive impairment (MCI) by reducing telomere shortening, a cellular marker of aging. We investigated whether combined physical/cognitive training affects leukocyte telomere length (LTL) in the randomized trial “Train the Brain”. LTL was assessed in 94 MCI (75.1 ± 5.1 years) subjects and 37 non-MCI subjects (73.2 ± 4.6 years). MCI patients were assigned to receive either 7 months of training or standard care. After 7 months, both groups were reassessed for changes in LTL and the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog). Telomerase reverse transcriptase (hTERT) mRNA and telomeric repeat-containing RNA (TERRA) were also tested in 24 patients. MCI patients had shorter LTL than controls (p = 0.02), and short LTL was associated with a higher risk of MCI (ORadjusted = 2.6; 95%CI, 1.1–6.0; p = 0.03). Training improved ADAS-cog scores (T0 = 15.1 ± 4.8 to T7 = 13.4 ± 5.0, p = 0.01) and increased LTL (T0 = 0.97 ± 0.21 to T7 = 1.04 ± 0.23, p = 0.04). hTERT mRNA levels were negligible in MCI patients at T0 and T7, indicating inactive telomerase. TERRA expression increased in untrained MCI (p = 0.02), which may reflect impaired telomere homeostasis. MCI patients have shorter telomeres, and combined training lengthens them, suggesting modifiable telomere homeostasis through non-pharmacological intervention. Telomere shortening may underlie increased telomeric transcription in untrained individuals, highlighting telomeric non-coding RNAs as potential therapeutic targets in age-related disease.
BET-induced metabolic reprogramming fuels inflammation at the vascular-fat interface in mice and patients with cardiometabolic disease Alessandro Mengozzi, Sarah Costantino, Alessia Mongelli, Emiliano Duranti, Shafeeq A. Mohammed, Era Gorica, Federica Cappelli, Marialucia Telesca, Silvia Armenia, Thorsten Hornemann, Andreas Hulsmeier, Carolina de Ciuceis, Claudia Agabiti-Rosei, Chiara Ippolito, Rosario Bellini, Nicola Riccardo Pugliese, Christian M. Matter, Omer Dzemali, Stefano Masi, Stefano Taddei, Frank Ruschitzka, Agostino Virdis, Francesco Paneni Cell Reports, 2026 Epigenetic reading of histone marks by BET proteins is emerging as a pivotal mechanism governing gene transcription and may be implicated in cardiometabolic disease (CMD). Using vessels from mice and patients with CMD, we show that pharmacological inhibition of BET proteins by RVX-208 prevents the maladaptive crosstalk between perivascular adipose tissue (PVAT) and blood vessels. The effect of the BET inhibitor on endothelial function was more pronounced in the presence of PVAT. In mouse and human PVAT, RVX-208 rescued maladaptive transcriptional programs with a marked downregulation of hexokinase-2 (HK2). This was associated with reduced glycolysis, lipid accumulation, and secretion of pro-inflammatory cytokines. In human adipocytes, HK2 overexpression induced a pro-inflammatory phenotype fostering endothelial damage. Pharmacological inhibition of HK2 in vessels from cardiometabolic patients restored endothelial-dependent vasorelaxation. This unveiling of a BET/HK2-dependent crosstalk between PVAT and blood vessels highlights the potential of therapeutic strategies to prevent vascular damage in cardiometabolic patients.
The Role of β-Blockers in the Evolving Treatment Landscape of Resistant Hypertension Stefano Masi, Atul Pathak, Rosa Maria Bruno, Sofie Brouwers, Krzysztof Narkiewicz, Stefano Taddei, Konstantinos Tsioufis, Reinhold Kreutz Drugs, 2026 Resistant hypertension (RHTN) is estimated to affect approximately 15% of all patients with hypertension, although its reported prevalence varies according to the blood pressure (BP) thresholds used for diagnosis, the criteria applied to exclude secondary or pseudoresistant hypertension, and the characteristics of the study populations. Regardless of its current prevalence, RHTN is expected to be encountered with increasing frequency in routine clinical practice, driven by the rising prevalence of conditions that are directly or indirectly linked with its increased risk, such as obesity, diabetes mellitus, and chronic kidney disease (CKD). Consequently, recent clinical trials and hypertension guidelines have devoted substantial attention to RHTN, also considering its association with an increased risk of cardiovascular events and renal failure. In this narrative review, we summarize mechanistic insights and evidence from randomized clinical trials and real-world studies, as well as recommendations from current international guidelines, to provide an updated perspective on the management of RHTN. Among multiple systems, activation of the sympathetic nervous system (SNS) and the renin-angiotensin-aldosterone system represents a central pathophysiological mechanism in RHTN, promoting sodium retention and vascular dysfunction. β-blockers counteract SNS overactivity, a target mechanism not addressed by other first-line therapies, and have compelling indications in most comorbidities associated with RHTN, including coronary artery disease, heart failure, and atrial fibrillation. They can be used across diverse patient populations, including those with advanced CKD, and their side effects can be readily monitored and managed. Evidence from randomized trials and real-world studies supports their efficacy, tolerability, and safety even in high-risk populations. Emerging strategies, including a quadruple single-pill combination containing a β-blocker, may enhance adherence, optimize BP control, and simplify RHTN management.
Pitfalls in the pharmacotherapy of hypertension Ryan J. McNally, Maisarah Amran, Albert Ferro, Carmela Maniero, Stefano Taddei, Luca Faconti Clinical Medicine Journal of the Royal College of Physicians of London, 2026 Despite the widespread availability of effective antihypertensive medications, blood pressure control remains unsatisfactory in a large number of patients, often due to avoidable dosing misconceptions rather than actual treatment resistance. This educational review aims to facilitate continuing medical education and clinical practice by exploring existing challenges in the pharmacological management of hypertension, focusing on the common drugs prescribed to manage hypertension. After reading this article, clinicians should be able recognise non-linear dose-response relationships, select appropriate medications and doses to achieve better blood pressure control, improve compliance alongside managing side effects that have led to premature discontinuation of beneficial medications. The review further explores how pharmacokinetic properties and patient-specific considerations, such as renal function and ethnicity, might influence choice of antihypertensive medications. This article aims to strengthen clinical choice, medication adherence and long-term management of blood pressure.
Exhaled breath acetone: a non-invasive marker of disease severity across the spectrum of heart failure Nicolò De Biase, Silvia Ghimenti, Lavinia Del Punta, Denise Biagini, Alessio Lenzi, Fabio Di Francesco, Stefano Taddei, Pierpaolo Pellicori, Stefano Masi, Tommaso Lomonaco, Nicola Riccardo Pugliese Journal of Breath Research, 2026 Background. Increased exhaled breath acetone (EBA) concentrations might reflect impaired myocardial energetics and haemodynamic stress. We investigated the relation of EBA and cardiac structure, function, and exercise capacity in patients with or at risk of heart failure (HF). Methods. We enrolled outpatients with HF and reduced (<50%, HFrEF) or preserved (>50%, HFpEF) left ventricular ejection fraction (LVEF) and subjects with cardiovascular risk factors and/or structural heart disease without established HF. All participants underwent clinical and laboratory evaluation, resting transthoracic echocardiography, and a combined cardiopulmonary-echocardiographic stress test with EBA monitoring at rest (EBA rest ) and during exercise (EBA ex ). Results. Patients with HFpEF ( n = 62) were older and more often female than those at risk of HF ( n = 50) or with HFrEF ( n = 41). EBA rest (1.5, interquartile range (IQR) 1.0–3.1 vs 0.9, IQR 0.7–1.2 mcg l −1 ) and EBA ex (2.4, IQR 1.5–4.4 vs 1.1, IQR 0.9–2.1 mcg l −1 ; all p < 0.0001) were significantly higher in patients with HF compared to others. Among HF patients, those in the highest EBA rest tertile had lower LVEF, greater echocardiographic signs of congestion, higher NT-proBNP levels, and lower peak oxygen consumption, indicating impaired exercise capacity. In multivariate regression, NT-proBNP ( p = 0.0004) and the slope of minute ventilation to carbon dioxide production ( p = 0.0013) were independent predictors of EBA rest (adjusted R 2 = 0.458). Conclusions. EBA concentrations are higher in patients with HF compared to those without, regardless of LVEF, and are associated with markers of disease severity. Further studies are needed to determine whether EBA measurement can aid in HF diagnosis and management.
Hemodynamic and Metabolic-Inflammatory Phenotyping Across the Cardiac Index Spectrum in Moderate and Severe Tricuspid Regurgitation: Prognostic Implications Matteo Mazzola, Nicolò De Biase, Cristina Giannini, Alessandro Sticchi, Lavinia Del Punta, Luna Gargani, Alessandro Mengozzi, Agostino Virdis, Silvia Armenia, Federica Cappelli, Emiliano Duranti, Stefano Taddei, Rebecca Hahn, David Messika-Zeitoun, Stefano Masi, Marco De Carlo, Nicola Riccardo Pugliese Circulation Cardiovascular Imaging, 2026 BACKGROUND: Moderate and severe tricuspid regurgitation (TR) is associated with poor outcomes, yet current grading systems do not fully capture circulatory heterogeneity. We investigate the relationship of cardiac index (CI) with rest-exercise hemodynamics, metabolic and inflammatory profiles, and clinical outcomes in moderate and severe TRs. METHODS: We prospectively enrolled 300 outpatients with atrial secondary, nonatrial secondary, and lead-associated moderate and severe TRs without ≥moderate left-sided valve disease. All underwent comprehensive laboratory profiling and ultrasound evaluation at rest and during cardiopulmonary exercise. Patients were stratified by CI tertiles and followed clinically (primary end point: all-cause mortality or heart failure hospitalization). RESULTS: CI decreased with TR severity but showed wide interindividual variability. In patients with low CI, severe forward flow limitation was associated with more advanced right ventricle-pulmonary arterial uncoupling and biatrial dysfunction ( P <0.05 versus the other tertiles), identifying a hypodynamic-uncoupled profile. Conversely, high CI identified a hyperdynamic-congestive phenotype characterized by advanced congestion, reduced systemic vascular resistance, and heightened systemic inflammation, metabolic-nutritional derangements, and mitochondrial dysfunction ( P <0.05 versus the other tertiles). Intermediate CI showed the most favorable hemodynamic and laboratory profile. A U-shaped relationship between CI and adverse outcomes was observed, with the lowest risk at intermediate values. This pattern persisted across TR severity, cause, staging systems, and adiposity categories ( P <0.05 for all). CONCLUSIONS: In moderate and severe TRs, CI profiling captures cardiac and extracardiac determinants of flow and independently predicts outcomes beyond conventional TR grading and staging. Both low and high CIs identify high-risk patients, while an intermediate CI indicates a balanced, prognostically favorable state. CI profiling may refine risk stratification, guide individualized treatment strategies, and optimize patient selection and timing for tricuspid valve interventions.
Circulating miR-122-5p, miR-125b-5p, and miR-27a-3p in Post-Mortem Whole Blood: An Exploratory Study of the Association with Sepsis-Related Death Carla Occhipinti, Andrea Scatena, Emanuela Turillazzi, Diana Bonuccelli, Paolo Pricoco, Marco Fornili, Aniello Maiese, Stefano Taddei, Marco Di Paolo, Anna Rocchi Current Issues in Molecular Biology, 2026 Accurate post-mortem diagnosis of sepsis remains a critical challenge in forensic pathology, as conventional morphological findings often lack specificity. Circulating microRNAs (miRNAs) have been proposed as stable molecular biomarkers, yet their diagnostic value in cadaveric samples is still unclear. This exploratory study investigated the expression of three candidate miRNAs (miR-122-5p, miR-125b-5p, and miR-27a-3p) in post-mortem peripheral whole blood to assess their association with sepsis-related death versus non-infective controls. Out of 58 cases, 45 met quality-control criteria (26 sepsis-related deaths and 19 controls). miRNA expression was quantified by qRT-PCR, normalized to miR-320, and analyzed using ΔCt values. Group differences were evaluated using linear regression models with adjustment for age, sex, and post-mortem interval, with Benjamini–Hochberg correction for multiple testing. In adjusted models, miR-125b-5p and miR-27a-3p showed evidence of association with sepsis status, whereas miR-122-5p did not. These results support the feasibility of miRNA quantification in post-mortem samples and motivate validation in larger, independent cohorts and within multimodal post-mortem diagnostic frameworks.
Hypertension in autoimmune rheumatic diseases – a position paper from the ESH working group on small arteries Eugenia Gkaliagkousi, Michael Doumas, Antonios Lazaridis, Carolina de Ciuceis, Claudia Agabiti-Rosei, Krzysztof Narkiewicz, Panagiota Anyfanti, Anastasia Malliora, Konstantinos Stellos, Nikolaos Vlachogiannis, Maria S. Stoenoiu, Konstantinos Stavropoulos, Theodoros Dimitroulas, Georgios Mavraganis, Kimon Stamatelopoulos, Dimitrios Terentes-Printzios, Ignatios Ikonomidis, Francisco Rios, Barbara Anna Kutryb-Zając, Francesco Paneni, Alessandro Mengozzi, Ryszard Nosalski, Georgios Georgiopoulos, George Pavlidis, Simon Tual-Chalot, Livia Camargo, Federica Cappelli, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Augusto Montezano, Pawel Winklewski, Jacek Wolf, Sarah Costantino, Ines Drenjančević, Stefano Taddei, Tomasz Guzik, Reinhold Kreutz, Christian Delles, Rhian Touyz, Alexandre Persu, Thomas Weber, Margus Viigimaa, Guido Grassi, Agostino Virdis Journal of Hypertension, 2026 Clinical management of hypertension in patients with autoimmune rheumatic diseases (ARDs) is challenging. Firstly, the impact on blood pressure (BP) of several antirheumatic drugs varies and the available evidence points towards a wide range of effects. Secondly, management of hypertension in terms of diagnosis, BP thresholds and therapeutic targets currently follows the general recommendations, even though patients with ARDs present a markedly adverse cardiovascular profile. Thirdly, lifestyle interventions in terms of non-pharmaceutical management follow the general recommendations. Notably, it has been shown that they can improve autoimmune disease-specific endpoints, however, their intimate effect on BP has not been fully explored. Finally, the choice of anti-hypertensive medication currently complies with the general antihypertensive therapy recommendations, in the absence of appropriately designed studies in these populations. This review aims to summarize the impact of antirheumatic drugs on BP and present the available data regarding clinical management of hypertension in patients with ARDs.
Hypertension in autoimmune rheumatic diseases: a position paper from the European Society of Hypertension working group on small arteries. Part A: pathophysiology, prevalence and cardiovascular risk estimation Eugenia Gkaliagkousi, Antonios Lazaridis, Carolina de Ciuceis, Michael Doumas, Krzysztof Narkiewicz, Claudia Agabiti-Rosei, Panagiota Anyfanti, Anastasia Malliora, Konstantinos Stellos, Nikolaos Vlachogiannis, Maria S. Stoenoiu, Konstantinos Stavropoulos, Theodoros Dimitroulas, Georgios Mavraganis, Kimon Stamatelopoulos, Dimitrios Terentes-Printzios, Ignatios Ikonomidis, Francisco Rios, Barbara Anna Kutryb-Zając, Francesco Paneni, Alessandro Mengozzi, Ryszard Nosalski, Georgios Georgiopoulos, George Pavlidis, Simon Tual-Chalot, Livia Camargo, Federica Cappelli, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Augusto Montezano, Pawel Winklewski, Jacek Wolf, Sarah Costantino, Ines Drenjančević, Stefano Taddei, Tomasz Guzik, Reinhold Kreutz, Christian Delles, Rhian Touyz, Alexandre Persu, Thomas Weber, Margus Viigimaa, Guido Grassi, Agostino Virdis Journal of Hypertension, 2026
Prognostic Value of Exercise Right Ventricular–Pulmonary Arterial Coupling in Primary Mitral Regurgitation Sara Moura-Ferreira, Nicola Riccardo Pugliese, Mauricio Milani, Stefano Taddei, Annemie Jacobs, Nicolò De Biase, Sebastiaan Dhont, Maarten Falter, Youri Bekhuis, Wouter L’Hoyes, Sarah Hoedemakers, Steven Droogmans, Bernard Cosyns, Ruta Jasaityte, Guido Claessen, Lavinia Del Punta, Lieven Herbots, Marco De Carlo, Matteo Mazzola, Philippe B. Bertrand, Giosuè Falcetta, Philippe Debonnaire, Stefano Masi, Jan Verwerft Circulation, 2025
Circulating mitochondrial DNA signature in cardiometabolic patients Alessandro Mengozzi, Silvia Armenia, Nicolò De Biase, Lavinia Del Punta, Federica Cappelli, Emiliano Duranti, Virginia Nannipieri, Rossana Remollino, Domenico Tricò, Agostino Virdis, Stefano Taddei, Nicola Riccardo Pugliese, Stefano Masi Cardiovascular Diabetology, 2025
Contemporary medical therapy for heart failure across the ejection fraction spectrum: The OPTIPHARM-HF registry Riccardo M. Inciardi, Maurizio Volterrani, Gianluigi Savarese, Muthiah Vaduganathan, Chiara Oriecuia, Carlo M. Lombardi, Cristina Gussago, Piergiuseppe Agostoni, Pietro Ameri, Giuseppe Armentaro, Chiara Arzilli, Nadia Aspromonte, Andrea Attanasio, Roberto Badagliacca, Lucia Barbieri, Pier Paolo Bocchino, Francesca Bursi, Matteo Cameli, Martino Canonero, Jeness S. Campodonico, Teresa Capovilla, Erberto Carluccio, Stefano Carugo, Vincenzo Castiglione, Dario Catapano, Manlio Cipriani, Michele Correale, Domenico D'Amario, Raffaele De Caterina, Gaetano M. De Ferrari, Emilia D'Elia, Luca Di Odoardo, Michele Emdin, Luigi Falco, Giulia Ferrante, Alessandra Fornaro, Paolo Fornaro, Gionata Guastamiglio, Marco Guazzi, Massimo Iacoviello, Massimo Imazio, Enrico Incaminato, Maria Teresa La Rovere, Sergio Leonardi, Marta Maccallini, Giulia E. Mandoli, Daniele Masarone, Marco Masetti, Alberto Mazzoni, Marta Mazzotta, Marco Merlo, Luigi Moschini, Filippo Novarese, Alberto Palazzuoli, Maria C. Pastore, Giuseppe Patti, Roberto F.E. Pedretti, Stefano Pidello, Massimo F. Piepoli, Giuseppe Pinto, Luciano Potena, Claudia Raineri, Filippo M. Rubbo, Mario Sabatino, Andrea Salzano, Angela Sciacqua, Michele Senni, Paolo Severino, Gianfranco Sinagra, Barbara Sposato, Stefano Taddei, Alessandro Valleggi, Carlo Vignati, Dario Vizza, Claudia Specchia, Giuseppe Rosano, Marco Metra, the OPTIPHARM-HF investigators European Journal of Heart Failure, 2025
Associations of iron deficiency with cardiac function, congestion, exercise capacity and prognosis in heart failure Nicolò De Biase, Lavinia Del Punta, Wouter L'Hoyes, Pierpaolo Pellicori, John G.F. Cleland, Gabriele Masini, Luna Gargani, Sara Moura‐Ferreira, Sarah Hoedemakers, Valerio Di Fiore, Lieven Herbots, Jan Stassen, Alessandro Mengozzi, Silvia Armenia, Stefano Taddei, Stefano Masi, Jan Verwerft, Nicola Riccardo Pugliese European Journal of Heart Failure, 2025
Integrative assessment of congestion in heart failure using ultrasound imaging Valerio Di Fiore, Lavinia Del Punta, Nicolò De Biase, Pierpaolo Pellicori, Luna Gargani, Frank Lloyd Dini, Silvia Armenia, Myriam Li Vigni, Davide Maremmani, Stefano Masi, Stefano Taddei, Nicola Riccardo Pugliese Internal and Emergency Medicine, 2025
OPTImal PHARMacological therapy for patients with heart failure: Rationale and design of the OPTIPHARM-HF registry Riccardo M. Inciardi, Muthiah Vaduganathan, Carlo M. Lombardi, Cristina Gussago, Piergiuseppe Agostoni, Pietro Ameri, Nadia Aspromonte, Leonardo Calò, Matteo Cameli, Erberto Carluccio, Stefano Carugo, Manlio Cipriani, Raffaele De Caterina, Gaetano M. De Ferrari, Michele Emdin, Alessandra Fornaro, Marco Guazzi, Massimo Iacoviello, Massimo Imazio, Maria Teresa La Rovere, Sergio Leonardi, Marta Maccallini, Daniele Masarone, Luigi Moschini, Alberto Palazzuoli, Giuseppe Patti, Roberto F.E. Pedretti, Pasquale Perrone Filardi, Massimo F. Piepoli, Luciano Potena, Andrea Salzano, Angela Sciacqua, Michele Senni, Gianfranco Sinagra, Claudia Specchia, Stefano Taddei, Dario Vizza, Gianluigi Savarese, Giuseppe Rosano, Maurizio Volterrani, Marco Metra, and European Journal of Heart Failure, 2024
Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries Francisco J. Rios, Carolina de Ciuceis, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Livia L. Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Mariarosaria Lopreiato, Georgios Mavraganis, Alessandro Mengozzi, Augusto C. Montezano, Konstantinos Stavropoulos, Pawel J. Winklewski, Jacek Wolf, Sarah Costantino, Michael Doumas, Eugenia Gkaliagkousi, Guido Grassi, Tomasz J. Guzik, Ignatios Ikonomidis, Krzysztof Narkiewicz, Francesco Paneni, Damiano Rizzoni, Kimon Stamatelopoulos, Konstantinos Stellos, Stefano Taddei, Rhian M. Touyz, Agostino Virdis Hypertension, 2024
2023 ESH Guidelines for the management of arterial hypertension the Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA) Giuseppe Mancia, Reinhold Kreutz, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Maria Lorenza Muiesan, Konstantinos Tsioufis, Enrico Agabiti-Rosei, Engi Abd Elhady Algharably, Michel Azizi, Athanase Benetos, Claudio Borghi, Jana Brguljan Hitij, Renata Cifkova, Antonio Coca, Veronique Cornelissen, J. Kennedy Cruickshank, Pedro G. Cunha, A.H. Jan Danser, Rosa Maria de Pinho, Christian Delles, Anna F. Dominiczak, Maria Dorobantu, Michalis Doumas, María S. Fernández-Alfonso, Jean-Michel Halimi, Zoltán Járai, Bojan Jelaković, Jens Jordan, Tatiana Kuznetsova, Stephane Laurent, Dragan Lovic, Empar Lurbe, Felix Mahfoud, Athanasios Manolis, Marius Miglinas, Krzystof Narkiewicz, Teemu Niiranen, Paolo Palatini, Gianfranco Parati, Atul Pathak, Alexandre Persu, Jorge Polonia, Josep Redon, Pantelis Sarafidis, Roland Schmieder, Bart Spronck, Stella Stabouli, George Stergiou, Stefano Taddei, Costas Thomopoulos, Maciej Tomaszewski, Philippe Van de Borne, Christoph Wanner, Thomas Weber, Bryan Williams, Zhen-Yu Zhang, Sverre E. Kjeldsen Journal of Hypertension, 2023
The importance of microvascular inflammation in ageing and age-related diseases: A position paper from the ESH working group on small arteries, section of microvascular inflammation Alessandro Mengozzi, Carolina de Ciuceis, Raffaella Dell’oro, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Panagiota Anyfanti, Livia L. Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Georgios Mavraganis, Augusto C. Montezano, Francesco J. Rios, Pawel J. Winklewski, Jacek Wolf, Sarah Costantino, Eugenia Gkaliagkousi, Guido Grassi, Tomasz J. Guzik, Ignatios Ikonomidis, Krzysztof Narkiewicz, Francesco Paneni, Damiano Rizzoni, Kimon Stamatelopoulos, Konstantinos Stellos, Stefano Taddei, Rhian M. Touyz, Areti Triantafyllou, Agostino Virdis Journal of Hypertension, 2023
Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up Alessandro Sale, Marianna Noale, Simona Cintoli, Gloria Tognoni, Chiara Braschi, Nicoletta Berardi, Stefania Maggi, Lamberto Maffei, L Maffei, E Picano, M G Andreassi, A Angelucci, F Baldacci, L Baroncelli, T Begenisic, P F Bellinvia, N Berardi, L Biagi, J Bonaccorsi, E Bonanni, U Bonuccelli, A Borghini, C Braschi, M Broccardi, R M Bruno, M Caleo, C Carlesi, L Carnicelli, G Cartoni, L Cecchetti, M C Cenni, R Ceravolo, L Chico, S Cintoli, G Cioni, M Coscia, M Costa, G D’Angelo, P D’Ascanio, M De Nes, S Del Turco, E Di Coscio, M Di Galante, N di Lascio, F Faita, I Falorni, U Faraguna, A Fenu, L Fortunato, R Franco, L Gargani, R Gargiulo, L Ghiadoni, F S Giorgi, R Iannarella, C Iofrida, C Kusmic, F Limongi, M Maestri, M Maffei, S Maggi, M Mainardi, L Mammana, A Marabotti, V Mariotti, E Melissari, A Mercuri, S Micera, S Molinaro, R Narducci, T Navarra, M Noale, C Pagni, S Palumbo, R Pasquariello, S Pellegrini, P Pietrini, T Pizzorusso, A Poli, L Pratali, A Retico, E Ricciardi, G Rota, A Sale, S Sbrana, G Scabia, M Scali, D Scelfo, R Sicari, G Siciliano, F Stea, S Taddei, G Tognoni, A Tonacci, M Tosetti, S Turchi, L Volpi, and Age and Ageing, 2023
Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial Markus P Schlaich, Marc Bellet, Michael A Weber, Parisa Danaietash, George L Bakris, John M Flack, Roland F Dreier, Mouna Sassi-Sayadi, Lloyd P Haskell, Krzysztof Narkiewicz, Ji-Guang Wang, Christopher Reid, Markus Schlaich, Ivor Katz, Andrew Ajani, Sinjini Biswas, Murray Esler, Grahame Elder, Simon Roger, David Colquhoun, John Mooney, Tine De Backer, Alexandre Persu, Martin Chaumont, Jean-Marie Krzesinski, Thomas Vanassche, Ginette Girard, Lew Pliamm, Ernesto Schiffrin, Fatima Merali, George Dresser, Michel Vallee, Shivinder Jolly, Stephen Chow, Jiguang Wang, Jianjun Mu, Jing Yu, Hong Yuan, Yingqing Feng, Xin Zhang, Jianhong Xie, Ling Lin, Miroslav Soucek, Jiri Widimsky, Renata Cifkova, Jan Vaclavik, Martin Ullrych, Martin Lukac, Ivan Rychlik, Thomas Guldager Lauridsen, Ilkka Kantola, Jyrki Taurio, Olavi Ukkola, Olivier Ormezzano, Philippe Gosse, Michel Azizi, Pierre-Yves Courand, Pascal Delsart, Jean Michel Tartiere, Felix Mahfoud, Roland Schmieder, Johannes Stegbauer, Philipp Lurz, Michael Koziolek, Christian Ott, Nicole Toursarkissian, Konstantinos Tsioufis, Konstantinos Kyfnidis, Athanasios Manolis, Sotirios Patsilinakos, Pantelis Zebekakis, Apostolos Karavidas, Pall Denes, Katalin Bezzegh, Marianna Zsom, Laszlo Kovacs, Yehonatan Sharabi, Mazen Elias, Ivetta Sukholutsky, Chaim Yosefy, Irina Kenis, Shaul Atar, Massimo Volpe, Muiesan Maria Lorenza, Stefano Taddei, Guido Grassi, Franco Veglio, Jung Woo Son, Jang-Young Kim, Joong-Il Park, Chang Hoon Lee, Hae-Young Lee, Rasa Raugaliene, Jolanta Elena Marcinkeviciene, Roma Kavaliauskiene, Jaap Deinum, Abraham Kroon, Bert-Jan van den Born, Andrzej Januszewicz, Andrzej Tykarski, Jolanta Walczewska, Zbigniew Gaciong, Andrzej Wiecek, Marzena Chrostowska, Andrzej Kleinrok, Jan Krekora, Grzegorz Kania, Anna Podrazka-Szczepaniak, Cezary Golawski, Maciej Podziewski, Barbara Kaczmarek, Grzegorz Skoczylas, Andrzej Wilkolaski, Iwona Wozniak, Marzena Janik-Palazzolo, Barbara Rewerska, Aleksandra Konradi, Yuriy Shvarts, Tamara Pecherina, Konstantin Nikolaev, Gapon Liudmila, Olga Orlikova, Viktor Mordovin, Natalia Petrochenkova, Gadel Kamalov, Elena Kosmacheva, Konstantin Nikolaev, Vadim Tyrenko, Vladimir Gorbunov, Andrey Obrezan, Tatiana Supryadkina, Irina Ler, Oleg Kotenko, Anatoly Kuzin, Fernando Martínez García, Josep Redon, Anna Oliveras, Luis Beltran Romero, Valerii Shatylo, Leonid Rudenko, Andriy Bazylevych, Yurii Rudyk, Oleksandr Karpenko, Mykola Stanislavchuk, Vira Tseluyko, Mykola Kushnir, Ervin Asanov, Yuriy Sirenko, Andriy Yagensky, David Collier, Pankaj Gupta, David Webb, Mary MacLeod, James McLay, Aaron Peace, Samir Arora, Patricia Buchanan, Robert Harris, Ronald Degarmo, Mario Guillen, Adam Karns, Joel Neutel, Yogesh Paliwal, Karlton Pettis, Phillip D. Toth, Jeffrey M. Wayne, Michael Bain Butcher, Phillip M. Diller, Suzanne Oparil, David Calhoun, Donald Brautigam, John Flack, Jesse M. Goldman, Arash Rashidi, Nabeel Aslam, William Haley, Nabil Andrawis, Brian Lang, Randy Miller, James Powell, Robert Dewhurst, James Pritchard, Dinesh Khanna, Dennis Tang, Nashwa Gabra, Jean Park, Conigliaro Jones, Cranford Scott, Blanca Luna, Murtaza Mussaji, Ravi Bhagwat, Michael Bauer, John McGinty, Rajesh Nambiar, Renee Sangrigoli, William Ross Davis, William Eaves, Frank McGrew, Ahmed Awad, Eric Bolster, David Scott, Paramjit Kalirao, Pascal Dabel, Wesley Calhoun, Steven Gouge, Mark Warren, Mary Katherine Lawrence, Aamir Jamal, Mohamed El-Shahawy, Carlos Mercado, Jayant Kumar, Pedro Velasquez-Mieyer, Robert Busch, Todd Lewis, Lisa Rich Lancet, 2022
Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved Stefan D. Anker, Javed Butler, Muhammad Shariq Usman, Gerasimos Filippatos, João Pedro Ferreira, Edimar Bocchi, Michael Böhm, Hans Pieter Brunner-La Rocca, Dong-Ju Choi, Vijay Chopra, Eduardo Chuquiure, Nadia Giannetti, Juan Esteban Gomez-Mesa, Stefan Janssens, James L. Januzzi, José R. González-Juanatey, Bela Merkely, Stephen J. Nicholls, Sergio V. Perrone, Ileana L. Piña, Piotr Ponikowski, Michele Senni, David Sim, Jindrich Spinar, Iain Squire, Stefano Taddei, Hiroyuki Tsutsui, Subodh Verma, Dragos Vinereanu, Jian Zhang, Tomoko Iwata, Janet M. Schnee, Martina Brueckmann, Stuart J. Pocock, Faiez Zannad Nature Medicine, 2022
Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial Subodh Verma, Nitish K Dhingra, Javed Butler, Stefan D Anker, Joao Pedro Ferreira, Gerasimos Filippatos, James L Januzzi, Carolyn S P Lam, Naveed Sattar, Barbara Peil, Matias Nordaby, Martina Brueckmann, Stuart J Pocock, Faiez Zannad, Milton Packer, M Packer, S Anker, J Butler, G Filippatos, S Pocock, F Zannad, JP Ferreira, M Brueckmann, J George, W Jamal, FK Welty, M Palmer, T Clayton, KG Parhofer, TR Pedersen, B Greenberg, MA Konstam, KR Lees, P Carson, W Doehner, A Miller, M Haas, S Pehrson, M Komajda, I Anand, J Teerlink, A Rabinstein, T Steiner, H Kamel, G Tsivgoulis, J Lewis, J Freston, N Kaplowitz, J Mann, J Petrie, S Perrone, S Nicholls, S Janssens, E Bocchi, N Giannetti, S Verma, J Zhang, J Spinar, M-F Seronde, M Boehm, B Merkely, V Chopra, M Senni, S Taddi, H 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Empagliflozin in heart failure with a preserved ejection fraction Stefan D. Anker, Javed Butler, Gerasimos Filippatos, João P. Ferreira, Edimar Bocchi, Michael Böhm, Hans-Peter Brunner–La Rocca, Dong-Ju Choi, Vijay Chopra, Eduardo Chuquiure-Valenzuela, Nadia Giannetti, Juan Esteban Gomez-Mesa, Stefan Janssens, James L. Januzzi, Jose R. Gonzalez-Juanatey, Bela Merkely, Stephen J. Nicholls, Sergio V. Perrone, Ileana L. Piña, Piotr Ponikowski, Michele Senni, David Sim, Jindrich Spinar, Iain Squire, Stefano Taddei, Hiroyuki Tsutsui, Subodh Verma, Dragos Vinereanu, Jian Zhang, Peter Carson, Carolyn Su Ping Lam, Nikolaus Marx, Cordula Zeller, Naveed Sattar, Waheed Jamal, Sven Schnaidt, Janet M. Schnee, Martina Brueckmann, Stuart J. Pocock, Faiez Zannad, Milton Packer New England Journal of Medicine, 2021
The European/international fibromuscular dysplasia registry and initiative (FEIRI) - Clinical phenotypes and their predictors based on a cohort of 1000 patients Marco Pappaccogli, Silvia Di Monaco, Ewa Warchoł-Celińska, Aurélien Lorthioir, Laurence Amar, Lucas S Aparicio, Christophe Beauloye, Rosa Maria Bruno, Patrick Chenu, Peter de Leeuw, Tine De Backer, Philippe Delmotte, Zivka Dika, Daniel Gordin, Hilde Heuten, Yoshio Iwashima, Jean-Marie Krzesinski, Abraham A Kroon, Lucia Mazzolai, Esteban Poch, Pantelis Sarafidis, Christophe Seinturier, Wilko Spiering, Laurent Toubiana, Patricia Van der Niepen, Daan van Twist, Adriana Visonà, Jean-Claude Wautrecht, Helena Witowicz, Jianzhong Xu, Aleksander Prejbisz, Andrzej Januszewicz, Michel Azizi, Alexandre Persu, Lucas S Aparicio, Alexandre Persu, Marco Pappaccogli, Christophe Beauloye, Patrick Chenu, Frank Hammer, Pierre Goffette, Parla Astarci, André Peeters, Robert Verhelst, Miikka Vikkula, Patricia Van der Niepen, Frank Van Tussenbroek, Tine De Backer, Sofie Gevaert, Dimitri Hemelsoet, Luc Defreyne, Hilde Heuten, Laetitia Yperzeele, Thijs Van der Zijden, Jean-Philippe Lengelé, Jean-Marie Krzesinski, Muriel Sprynger, Philippe Delmotte, Peter Verhamme, Thomas Vanassche, Pasquale Scoppettuolo, Jean-Claude Wautrecht, Wouter Vinck, Vassilev Dobrin, Yaneva Teodora, Jiguang Wang, Jianzhong Xu, Bojan Jelaković, Zivka Dika, Daniel Gordin, Ilkka Tikkanen, Maarit Venermo, R N Mäkelä, Pierre-François Plouin, Xavier Jeunemaitre, Laurent Toubiana, Michel Azizi, Laurence Amar, Antoine Chédid, Elie Mousseaux, Aurélien Lorthioir, Olivier Ormezzano, Christopher Seinturier, Frédéric Thony, Felix Mahfoud, Saarraaken Kulenthiran, Pantelis Sarafidis, Alexia Piperidou, Michael Doumas, George S Stergiou, Demetrios Vlahakos, Caitriona Canning, Yehonatan Sharabi, Alberto Morganti, Rosa Maria Bruno, Stefano Taddei, Caterina Romanini, Ilaria Petrucci, Franco Rabbia, Marco Pappaccogli, Silvia Di Monaco, Gian Paolo Rossi, Silvia Lerco, Pietro Minuz, Giancarlo Mansueto, Sergio De Marchi, Denise Marcon, Patrizia Salice, Adriana Visonà, Paola Bigolin, Viviana Zingaretti, Rosario Cianci, Marialuisa Zedde, Maria Chiara Matteucci, Yoshio Iwashima, Osami Kawarada, Yoshito Kadoya, Daan J van Twist, Bram Kroon, Peter de Leeuw, Wilko Spiering, Bert-Jan van den Born, Aud Høieggen, Martin Skage Sommer, Andrzej Januszewicz, Ewa Warchoł-Celińska, Aleksander Prejbisz, Adam Witkowski, Helena Witowicz, Jacek Kądziela, Aleksandra Soplińska, Krzysztof Pieluszczak, Katarzyna Jóżwik-Plebanek, Magdalena Januszewicz, Elżbieta Florczak, Piotr Dobrowolski, Eva Szabóová, Marek Hudák, Matej Moščovič, Juan Diego Mediavilla, Fernando Jaen Aguila, Anna Oliveras, Julian Segura, Jose C Prado, Nicolas Roberto Robles, Esteban Poch, Enrique Montagud-Marrahi, Alicia Molina, Elena Guillen, Marta Burrel, Patricia Fernàndez De la Llama, Antonio J Barros-Membrilla, Anders Gottsäter, Gregor Wuerzner, Lucia Mazzolai, Giacomo Buso, Faiçal Jarraya, Hanen Chaker, David Adlam, Constantina Chrysochou, Neeraj Dhaun, Robert W Hunter, Iain MacIntyre, David Webb, and Cardiovascular Research, 2021
Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Muhammad Shahzeb Khan, João Pedro Ferreira, Edimar Bocchi, Michael Böhm, Hans Pieter Brunner‐La Rocca, Dong‐Ju Choi, Vijay Chopra, Eduardo Chuquiure, Nadia Giannetti, Juan Esteban Gomez‐Mesa, Stefan Janssens, James L. Januzzi, Jose R. Gonzalez‐Juanatey, Bela Merkely, Stephen J. Nicholls, Sergio V. Perrone, Ileana L. Piña, Piotr Ponikowski, Michele Senni, Marie‐France Seronde, David Sim, Jindrich Spinar, Iain Squire, Stefano Taddei, Hiroyuki Tsutsui, Subodh Verma, Dragos Vinereanu, Jian Zhang, Waheed Jamal, Sven Schnaidt, Janet M. Schnee, Martina Brueckmann, Stuart J. Pocock, Faiez Zannad, Milton Packer, and European Journal of Heart Failure, 2020
Cardiovascular and renal outcomes with empagliflozin in heart failure Milton Packer, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Stuart J. Pocock, Peter Carson, James Januzzi, Subodh Verma, Hiroyuki Tsutsui, Martina Brueckmann, Waheed Jamal, Karen Kimura, Janet Schnee, Cordula Zeller, Daniel Cotton, Edimar Bocchi, Michael Böhm, Dong-Ju Choi, Vijay Chopra, Eduardo Chuquiure, Nadia Giannetti, Stefan Janssens, Jian Zhang, Jose R. Gonzalez Juanatey, Sanjay Kaul, Hans-Peter Brunner-La Rocca, Bela Merkely, Stephen J. Nicholls, Sergio Perrone, Ileana Pina, Piotr Ponikowski, Naveed Sattar, Michele Senni, Marie-France Seronde, Jindrich Spinar, Iain Squire, Stefano Taddei, Christoph Wanner, Faiez Zannad New England Journal of Medicine, 2020
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