Amal Mohamed Kamal Abdelmoaty Kabbash

@tanta.edu.eg

Tanta pharmacy

Amal Mohamed Kamal Abdelmoaty Kabbash


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https://researchid.co/am.kabbash
35

Scopus Publications

1577

Scholar Citations

16

Scholar h-index

27

Scholar i10-index

Scopus Publications

  • Molecular networking based on UPLC-MS/MS fingerprinting for evaluation of Atriplex lindleyi Moq. subsp. inflata's renoprotective potential
    Abdelrahman A. Ziada, Amal Kabbash, Mona El-Aasr, Mohamed A. Selim, Rehab F. Abdel-Rahman, et al.
    South African Journal of Botany, 2026
  • The use of the white biotechnology toolkit to edit natural purines for studying their anticancer activity via mTOR pathway
    Ahmed M. Younis, Ghada Attia, Mohamed M. Saleh, Mahmoud A.A. Ibrahim, Mohamed-Elamir F. Hegazy, et al.
    Bioorganic Chemistry, 2025
  • LC-MS/MS metabolomics approach for chemical characterization of Beta vulgaris subspecies maritima extract through untargeted molecular networking, in correlation to its renoprotective activity in renal ischemia/reperfusion induced injury model in rats
    Abdelrahman A. Ziada, Amal Kabbash, Mona El-Aasr, Mohamed A. Selim, Rehab F. Abdel-Rahman, et al.
    Food Bioscience, 2024
  • Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities
    Lamiaa A. Al-Madboly, Akira Yagi, Amal Kabbash, Mona A. El-Aasr, Rasha M. El-Morsi
    BMC Microbiology, 2023
    Background Fermented Aloe leaf juice is a commonly used food supplement in Japan. In a previous study, fermentation of A. arborescence juice was performed and the presence of short-chain fatty acids (SCFAs) was confirmed and quantified. Samples were collected before and after the fermentation process to be subjected, in the present study, to DNA extraction, 16S rRNA gene (V3–V4 regions) amplification, and sequencing by the next-generation Illumina MiSeq sequencer. Our work aims to analyze the sequences to assess the bacterial diversity in the juice before and after fermentation, identify the beneficial microbes responsible for the production of SCFAs, and evaluate some of the biological activities of the fermented juice. Results Data revealed the richness and diversity of the bacterial community in the fermented juice compared to the unfermented control. Relative abundance of bacterial phyla showed that the majority of the microbial community in the test samples corresponded to Pseudomonadota (unfermented; 10.4%, fermented; 76.36%), followed by Bacillota (unfermented; 4.71%, fermented; 17.13%) and then Bacteroidota (unfermented; 0.57%, fermented; 1.64%). For the fermented sample, 84% of Bacillota were lactobacilli. A hierarchically clustered heatmap revealed that Lactobacillus was the most abundant genus in both samples suggesting its involvement in the production of SCFAs. To assess potential health benefits, the anticancer efficacy of the fermented product of A. arborescens was investigated against colorectal cancer (IC50 = 3.5 µg/ml) and liver cancer (IC50 = 6.367 µg/ml) compared to the normal peripheral blood mononuclear cells (PBMCs). Flow cytometric analysis of the cell cycle pattern revealed remarkable population arrest in G0 and G1, however, the highest percentages were mainly in the G1 phase for Hep-G2 (40.1%) and HCT-116 (53.2%) cell lines. This effect was accompanied by early apoptotic profiles of HCT-116 (36.9%) and late apoptosis for Hep-G2 (17.3%). Furthermore, immunomodulatory properties demonstrated a significantly (p < 0.001) reduced percentage of induced TNF-α while enhancing IFN-γ dramatically. For antimicrobial activities, marked broad-spectrum activities were recorded against some bacterial and fungal pathogens (17–37 mm inhibition zone diameter range). Conclusion Therefore, this study affords the basis of bacterial community composition in fermented A. arborescens juice as well as its potential biological benefits.
  • Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening
    Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O. Tawfik, Gaber El-Saber Batiha, et al.
    Molecules, 2023
    Bioconversion of biosynthetic heterocyclic compounds has been utilized to produce new semisynthetic pharmaceuticals and study the metabolites of bioactive drugs used systemically. In this investigation, the biotransformation of natural heterocyclic alkaloid papaverine via filamentous fungi was explored. Molecular docking simulations, using protein tyrosine phosphatase 1B (PTP1B), α-glucosidase and pancreatic lipase (PL) as target enzymes, were performed to investigate the antidiabetic potential of papaverine and its metabolites in silico. The metabolites were isolated from biotransformation of papaverine with Cunninghamella elegans NRRL 2310, Rhodotorula rubra NRRL y1592, Penicillium chrysogeneum ATCC 10002 and Cunninghamella blackesleeana NRRL 1369 via reduction, demethylation, N-oxidation, oxidation and hydroxylation reactions. Seven metabolites were isolated: namely, 3,4-dihydropapaverine (metabolite 1), papaveroline (metabolite 2), 7-demethyl papaverine (metabolite 3), 6,4′-didemethyl papaverine (metabolite 4), papaverine-3-ol (metabolite 5), papaverinol (metabolite 6) and papaverinol N-oxide (metabolite 7). The structural elucidation of the metabolites was investigated with 1D and 2D NMR and mass spectroscopy (EI and ESI). The molecular docking studies showed that metabolite 7 exhibited better binding interactions with the target enzymes PTP1B, α-glucosidase and PL than did papaverine. Furthermore, papaverinol-N-oxide (7) also displayed inhibition of α-glucosidase and lipase enzymes comparable to that of their ligands (acarbose and orlistat, respectively), as unveiled with an in silico ADMET profile, molecular docking and molecular dynamics studies. In conclusion, this study provides evidence for enhanced inhibition of PTP1B, α-glucosidase and PL via some papaverine fungal transformation products and, therefore, potentially better antidiabetic and antiobesity effects than those of papaverine and other known therapeutic agents.
  • Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect
    Nashwah G. M. Attallah, Amal Kabbash, Walaa A. Negm, Engy Elekhnawy, Reem Binsuwaidan, et al.
    Pharmaceuticals, 2023
    Diseases and infections of the respiratory tract are common global causes of morbidity and mortality. Our study attempts to elucidate a novel remedy for respiratory ailments, in addition to identifying and quantifying the metabolites of Saussurea costus root extract (SCRE) using HPLC. Then, in vitro antiviral and in vivo lung protective effects were elucidated. The in vitro antiviral potential of SCRE was analyzed via plaque assay against the low pathogenic human coronavirus (HCoV-229E) and human influenza virus (H1N1). The value of the half maximal inhibitory concentrations (IC50) of SCRE against HCoV-229E and H1N1 influenza virus were 23.21 ± 1.1 and 47.6 ± 2.3 µg/mL, respectively. SCRE showed a histological improvement, namely a decrease in inducible nitric oxide synthase (iNOS) and caspase-3 immunoexpression in in vivo cyclophosphamide (CP)-induced acute lung injury (ALI). Moreover, there was a considerable decline in microRNA-let-7a gene expression and a significant rise in heme oxygenase-1 (HO-1) gene expression, with a marked decrease in the malondialdehyde (MDA) level. Molecular docking studies revealed that the major constituents of SCRE have a good affinity for caspase-3, HO-1, and iNOS proteins. In conclusion, a traditional plant SCRE could be a promising source of novel therapeutic agents for treating and protecting respiratory tract diseases. More future investigations should be carried out to reveal its efficacy clinically.
  • Elucidation of Natural Components of Gardenia thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease
    Eman M. EL-Shial, Amal Kabbash, Mona El-Aasr, Ola A. El-Feky, Suzy A. El-Sherbeni
    Molecules, 2023
    The rising prevalence of non-alcoholic fatty liver disease NAFLD has strained the healthcare system. Natural products could solve this problem, so the current study focused on the impact of G. thunbergia Thunb. against this ailment. LC–ESI–MS/MS revealed the phytochemical profile of the methanol extract from Gardenia thunbergia leaves (GME). Forty-eight compounds were tentatively identified, and stigmasterol, fucosterol, ursolic acid, and rutin were isolated. The separation of the last three compounds from this plant had not before been achieved. The anti-NAFLD effect of the methanol extract of the leaves of G. thunbergia, and its major metabolite, rutin, was assessed in mice against high-fructose diet (HFD)-induced obesity. Male mice were allocated into nine groups: (1) saline (control), (2) 30% fructose (diseased group), (3) HFD, and 10 mg/kg of simvastatin. Groups 4–6 were administered HFD and rutin 50, 75, and 100 mg/kg. Groups (7–9) were administered HFD and methanol extract of leaves 100, 200, and 300 mg/kg. Methanol extract of G. thunbergia leaves at 200 mg/kg, and rutin at 75 mg/kg significantly reduced HFD-induced increments in mice weight and hepatic damage indicators (AST and ALT), steatosis, and hypertrophy. The levels of total cholesterol, LDL–C, and triglycerides in the blood decreased. In addition, the expressions of CYP2E1, JNK1, and iNOS in the diseased mice were downregulated. This study found that GME and rutin could ameliorate NAFLD in HFD-fed mice, with results comparable to simvastatin, validating G. thunbergia’s hepatoprotective effects.
  • Isonicotinic acid N-oxide, from isoniazid biotransformation by Aspergillus niger, as an InhA inhibitor antituberculous agent against multiple and extensively resistant strains supported by in silico docking and ADME prediction
    Amany E. Ragab, Ebtisam T. Badawy, Shaimaa M. Aboukhatwa, Marwa M. Abdel-Aziz, Amal Kabbash, et al.
    Natural Product Research, 2023
    Biotransformation of isoniazid produced isonicotinic acid (1), isonicotinic acid N-oxide (2), and isonicotinamide (3) which were isolated by column chromatography using silica gel and Sephadex LH 20 and elucidated using various spectroscopies. This is the first report for isolation of 2 . Antituberculosis activity was evaluated against Mycobacterium tuberculosis strains: drug sensitive (DS), multiple drug resistant (MDR) and extensively drug resistant (XDR). 1-3 and isoniazid showed MICs of 63.49, 0.22, 15.98 and 0.88 µM, respectively, against the DS strain. For the MDR strain, 2 and 3 exhibited MICs of 28.06 and > 1000 µM, respectively, while 1 was inactive. Moreover, 2 had an MIC of 56.19 µM against XDR strain, while 1 and 3 were inactive. Docking simulation using enoyl ACP reductase (InhA) revealed favorable protein-ligand interactions. In silico study of pharmacokinetics and hepatotoxicity predicted 1-3 to have good oral bioavailability and 2 to have a lower hepatoxicity probability than isoniazid. Graphical Abstract
  • In Vitro Characterization of Inhibitors for Lung A549 and Leukemia K562 Cell Lines from Fungal Transformation of Arecoline Supported by In Silico Docking to M3-mAChR and ADME Prediction
    Amany E. Ragab, Ebtisam T. Badawy, Shaimaa M. Aboukhatwa, Amal Kabbash, Kamilia A. Abo El-Seoud
    Pharmaceuticals, 2022
    The search for anticancer drugs is of continuous interest. Arecoline is an alkaloid with anticancer activity. Herein, the metabolism of arecoline through fungal transformation was investigated for the discovery of potential anticancer drugs with higher activity and selectivity. Compounds 1–5 were isolated, and their structures were fully elucidated using various spectroscopic analyses, including 1D and 2D NMR, ESIMS, and HRESIMS. This is the first report for the isolation of compounds 1 and 2. An MTT assay was performed to determine the cytotoxic activity of arecoline and its metabolites in vitro using non-small-cell lung cancer A549 and leukemia K562 cell lines compared to staurosporine and doxorubicin as positive controls. For the non-small-cell lung A549 cell line, arecoline hydrobromide, staurosporine, and doxorubicin resulted in IC50 values of 11.73 ± 0.71 µM, 10.47 ± 0.64 µM, and 5.05 ± 0.13 µM, respectively, while compounds 1, 3, and 5 exhibited IC50 values of 3.08 ± 0.19 µM, 7.33 ± 0.45 µM, and 3.29 ± 0.20 µM, respectively. For the leukemia K562 cell line, the IC50 values of arecoline hydrobromide, staurosporine, and doxorubicin were 15.3 ± 1.08 µM, 5.07 ± 0.36 µM, and 6.94 ± 0.21 µM, respectively, while the IC50 values of compounds 1, 3 and 5 were 1.56 ± 0.11 µM, 3.33 ± 0.24 µM, and 2.15 ± 0.15 µM, respectively. The selectivity index value of these compounds was higher than 3. These results indicated that compounds 1, 3, and 5 are very strong cytotoxic agents with higher activity than the positive controls and good selectivity toward the tested cancer cell lines. Cell cycle arrest was then studied by flow cytometry to investigate the apoptotic mechanism. Docking simulation revealed that most compounds possessed good binding poses and favorable protein-ligand interactions with muscarinic acetylcholine receptor M3-mAChR protein. In silico study of pharmacokinetics using SwissADME predicted compounds 1–5 to be drug-like with a high probability of good oral bioavailability.
  • Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
    Duaa Eliwa, Abdel-Rahim S. Ibrahim, Amal Kabbash, Mona El-Aasr, Michał Tomczyk, et al.
    Pharmaceuticals, 2022
    Natural nitrogen heterocycles biotransformation has been extensively used to prepare synthetic drugs and explore the fate of therapeutic agents inside the body. Herein, the ability of filamentous fungi to biotransform boldine and berberine was investigated. Docking simulation studies of boldine, berberine and their metabolites on the target enzymes: telomerase (TERT) and human protein tyrosine phosphatase 1B (PTP-1B) were also performed to investigate the anticancer and antidiabetic potentials of compounds in silico. The biotransformation of boldine and berberine with Cunninghamella elegans NRRL 2310, Rhodotorula rubra NRRL y1592, Penicillium chrysogeneum ATCC 10002, Cunninghamella blackesleeana MR198 and Cunninghamella blackesleeana NRRL 1369 via demethylation, N- oxidation, glucosidation, oxidation and hydroxylation reactions produced seven metabolites, namely: 1,10-didesmethyl-boldine (1), laurolitsine (2), 1,10-didesmethyl-norboldine (3), boldine-9-O-β-D-glucoside (4), tridesmethyl berberine (5), demethylene berberine (6), and lambertine (7). Primarily, the structures of the metabolites were established by one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) analyses and mass spectrometry. In silico molecular docking simulation of the metabolites of boldine and berberine to the proteins TERT and PTP-1B, respectively, revealed good binding MolDock scores comparable to boldine and berberine and favorable interactions with the catalytic sites of the proteins. In conclusion, this study presented promising biologically prepared nitrogen scaffolds (isoquinolines) of boldine and berberine.
  • Microbial transformation of some simple isoquinoline and benzylisoquinoline alkaloids and in vitro studies of their metabolites
    Mona El-Aasr, Duaa Eliwa, Mohamed Albadry, Abdel-Rahim S. Ibrahim, Amal Kabbash, et al.
    Phytochemistry, 2021
  • Comparison between tran abdominal and trans anal one stage pull through in hirschsprung disease
    Mansour Mohammed Kabbash, Mohammed Abd-Alkader Osman, Mohammed Youssef Ahmed, Mohamed Rabie, Mohammed Kandil Ibrahim
    Egyptian Journal of Hospital Medicine, 2021
  • Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a
    Duaa Eliwa, Mohamed A. Albadry, Abdel-Rahim S. Ibrahim, Amal Kabbash, Kumudini Meepagala, et al.
    Phytochemistry, 2021
  • Comparative study of antimicrobial activity and cytotoxicity of saponin extracted from six egyptian sea-cucumber species, licorice, and ginseng
    Samia H. Eissa, Hoda K. Salem, Nahla E. Omran, Amal M. Kabbash, Wesam H. Amer, et al.
    Natural Products Journal, 2021
  • Purification, Characterization, Identification, and Anticancer Activity of a Circular Bacteriocin From Enterococcus thailandicus
    Lamiaa A. Al-Madboly, Nehal M. El-Deeb, Amal Kabbash, Manal A. Nael, Ahmed M. Kenawy, et al.
    Frontiers in Bioengineering and Biotechnology, 2020
  • Chemotaxonomic study of the most abundant Egyptian sea-cucumbers using ultra-performance liquid chromatography (UPLC) coupled to high-resolution mass spectrometry (HRMS)
    Nahla E. Omran, Hoda K. Salem, Samia H. Eissa, Amal M. Kabbash, Manar A. Kandeil, et al.
    Chemoecology, 2020
  • Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of Dioon spinulosum leaves Dyer Ex Eichler and its isolated secondary metabolites
    Walaa A. Negm, Kamilia A. Abo El-Seoud, Amal Kabbash, Amira A. Kassab, Mona El-Aasr
    Natural Product Research, 2020
  • Antimicrobial and immunomodulatory activities of flavonol glycosides isolated from Atriplex halimus L. Herb
    Journal of Pharmaceutical Sciences and Research, 2016
  • Microbial transformation of curcumin and evaluation of the biological activities of the isolated metabolites
    Journal of Pharmaceutical Sciences and Research, 2016
  • Possible prophylaxes of Aloe Vera gel ingestion to butyrate metabolism
    Akira Yagi, Amal Kabbash, Lamiaa Al-Madboly
    Journal of Gastroenterology and Hepatology Research, 2016
  • Short chain fatty acids from fermentation by endophytic bacteria in Aloe vera leaf rind and gel
    Akira Yagi, Amal Kabbash, Lamiaa Abdullah Al-Madboly
    Journal of Gastroenterology and Hepatology Research, 2016
  • In vitro and In vivo hepatoprotective study of Inula crithmoides L.,Pluchea dioscoridis (L.) Desf. and Phyllanthus reticulates poir
    Journal of Pharmaceutical Sciences and Research, 2015
  • Chemical and biological investigation of some secondary metabolites in Atriplex halimus growing in Egypt
    Amal Kabbash, Nagwa Shoeib
    Natural Product Communications, 2012
  • Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction
    H. El-Shemy, M. Aboul-Soud, A. Nassr-Allah, K. Aboul-Enein, A. Kabash, et al.
    Current Medicinal Chemistry, 2010
  • Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients
    Akira Yagi, Sahar Hegazy, Amal Kabbash, Engy Abd-El Wahab
    Saudi Pharmaceutical Journal, 2009
  • Biological activity of Coumarins from Launaea resedifolia
    Pharmacognosy Magazine, 2008
  • Supercritical carbon dioxide extraction of aloe emodin and barbaloin from Aloe vera L. leaves and their in-vitro cytotoxic activity
    Saudi Pharmaceutical Journal, 2008
  • Potential effect of Curcuma longa extract on infectivity and pathogenicity of Schistosoma mansoni cercariae.
    Journal of the Egyptian Society of Parasitology, 2008
  • Isolation and identification of a new homoisoflavan with potent antioxidant activity from Commelina elegans
    Saudi Pharmaceutical Journal, 2008
  • Two new sesquiterpene coumarins, ferusinol and samarcandin diastereomer, from Ferula sinaica
    Iranian Journal of Pharmaceutical Research, 2007
  • Ribosomal DNA sequence analysis of different geographically distributed Aloe vera plants: Comparison with clonally regenerated plants
    Saudi Pharmaceutical Journal, 2006
  • Montanone, a new sesquiterpene from Jasonia montana
    Saudi Pharmaceutical Journal, 2006
  • Monoamine oxidase inhibitors from Gentiana lutea
    H HARAGUCHI, Y TANAKA, A KABBASH, T FUJIOKA, T ISHIZU, et al.
    Phytochemistry, 2004
  • Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from Aloe vera gel
    A. Yagi, A. Kabash, K. Mizuno, S. M. Moustafa, T. I. Khalifa, et al.
    Planta Medica, 2003
  • Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera
    A. Yagi, A. Kabash, N. Okamura, H. Haraguchi, S. M. Moustafa, et al.
    Planta Medica, 2002

RECENT SCHOLAR PUBLICATIONS

  • Molecular networking based on UPLC-MS/MS fingerprinting for evaluation of Atriplex lindleyi Moq. subsp. inflata's renoprotective potential
    AA Ziada, A Kabbash, M El-Aasr, MA Selim, RF Abdel-Rahman, HA Ogaly, ...
    South African Journal of Botany 189, 565-573 , 2026
    2026
  • The use of the white biotechnology toolkit to edit natural purines for studying their anticancer activity via mTOR pathway
    AM Younis, G Attia, MM Saleh, MAA Ibrahim, MEF Hegazy, PW Pare, ...
    Bioorganic Chemistry 159, 108391 , 2025
    2025
  • Fungal Screening of Some Natural Bioactive Purine-based Alkaloids For Efficient Biotransformation
    AM Younis, G Attia, A Kabbash, AS Ibrahim
    Journal of Advanced Medical and Pharmaceutical Research 5 (2), 113-120 , 2024
    2024
  • LC-MS/MS metabolomics approach for chemical characterization of Beta vulgaris subspecies maritima extract through untargeted molecular networking, in correlation to its …
    AA Ziada, A Kabbash, M El-Aasr, MA Selim, RF Abdel-Rahman, HA Ogaly, ...
    Food Bioscience 59, 104004 , 2024
    2024
    Citations: 7
  • Isoniazid, mechanism of action, biological activity, resistance and biotransformation
    ET Badawy, KA Abouelsaoud, A Kabbash, A Ragab
    Journal of Advanced Medical and Pharmaceutical Research 4 (2), 42-46 , 2023
    2023
    Citations: 7
  • Arecoline Biological Activity and Biotransformation: A review
    ET Badawy, KA Abouelsaoud, A Ragab, A Kabbash
    Journal of Advanced Medical and Pharmaceutical Research 4 (2), 27-34 , 2023
    2023
    Citations: 1
  • Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities
    LA Al-Madboly, A Yagi, A Kabbash, MA El-Aasr, RM El-Morsi
    BMC microbiology 23 (1), 240 , 2023
    2023
    Citations: 8
  • Isonicotinic acid N -oxide, from isoniazid biotransformation by Aspergillus niger , as an InhA inhibitor antituberculous agent against multiple and extensively resistant strains …
    AE Ragab, ET Badawy, SM Aboukhatwa, MM Abdel-Aziz, A Kabbash, ...
    Natural Product Research 37 (10), 1687-1692 , 2023
    2023
    Citations: 7
  • GC-MS Analysis of Bioactive Compounds of Gardenia thunbergia Thunb. Leaves and Antibiofilm Potential against Staphylococcus aureus Clinical Isolates
    EM EL-Shial, A Kabbash, M El-Aasr, E Elekhnawy, SA El-Sherbeni
    Journal of Advanced Medical and Pharmaceutical Research 4 (1), 11-18 , 2023
    2023
    Citations: 2
  • Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect
    NGM Attallah, A Kabbash, WA Negm, E Elekhnawy, R Binsuwaidan, ...
    Pharmaceuticals 16 (2), 318 , 2023
    2023
    Citations: 17
  • Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening
    D Eliwa, A Kabbash, M El-Aasr, HO Tawfik, GES Batiha, MH Mahmoud, ...
    Molecules 28 (4), 1583 , 2023
    2023
    Citations: 3
  • Elucidation of Natural Components of Gardenia thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease
    EM El-Shial, A Kabbash, M El-Aasr, OA El-Feky, SA El-Sherbeni
    Molecules 28 (2), 879 , 2023
    2023
    Citations: 19
  • Pharmacognostical and biological investigation of Dioon holmgrenii De Luca, Sabato & Vázq. Torres, Dioon mejiae Standl. & LO Williams, and Dioon meorlae De Luca, Sabato & Vázq …
    H El Gendy, SM Mostafa, A Kabbash, NA Shoeib
    Journal of Advanced Medical and Pharmaceutical Research 3 (2), 45-52 , 2022
    2022
    Citations: 3
  • Biotransformation of modified benzylisoquinoline alkaloids: boldine and berberine and in silico molecular docking studies of metabolites on telomerase and human protein …
    D Eliwa, ARS Ibrahim, A Kabbash, M El-Aasr, M Tomczyk, YA Bin Jardan, ...
    Pharmaceuticals 15 (10), 1195 , 2022
    2022
    Citations: 4
  • In vitro characterization of inhibitors for lung A549 and leukemia K562 cell lines from fungal transformation of arecoline supported by in silico docking to M3-mAChR and ADME …
    AE Ragab, ET Badawy, SM Aboukhatwa, A Kabbash, KA Abo El-Seoud
    Pharmaceuticals 15 (10), 1171 , 2022
    2022
    Citations: 12
  • Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages
    W Negm, A Kabbash, SM Ezzat, A Zayed
    Journal of Advanced Medical and Pharmaceutical Research 3 (1), 12-18 , 2022
    2022
    Citations: 2
  • Bin Jardan YA, Batiha GES, Ragab AE. Biotransformation of modified benzylisoquinoline alkaloids: boldine and berberine and in silico molecular docking studies of metabolites on …
    D Eliwa, ARS Ibrahim, A Kabbash, M El-Aasr, M Tomczyk
    Pharmaceuticals 15 (10), 1195 , 2022
    2022
    Citations: 7
  • Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of Dioon spinulosum leaves Dyer Ex Eichler and its isolated secondary metabolites
    WA Negm, KA Abo El-Seoud, A Kabbash, AA Kassab, M El-Aasr
    Natural product research 35 (23), 5166-5176 , 2021
    2021
    Citations: 34
  • Microbial transformation of some simple isoquinoline and benzylisoquinoline alkaloids and in vitro studies of their metabolites
    M El-Aasr, D Eliwa, M Albadry, ARS Ibrahim, A Kabbash, KM Meepagala, ...
    Phytochemistry 189, 112828 , 2021
    2021
    Citations: 9
  • Comparative study of antimicrobial activity and cytotoxicity of saponin extracted from six Egyptian sea-cucumber species, licorice, and ginseng
    SH Eissa, HK Salem, NE Omran, AM Kabbash, WH Amer, MA Kandeil
    The Natural Products Journal 11 (4), 491-506 , 2021
    2021
    Citations: 7

MOST CITED SCHOLAR PUBLICATIONS

  • Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera,
    KTI Yagi A, Kabbash A, Okamura N, Haraguchi H, Moustafa SM
    Planta Medica 68 (11), 957-60. , 2002
    2002
    Citations: 339
  • Antitumor Properties and Modulation of Antioxidant Enzymes’ Activity by Aloe vera Leaf Active Principles Isolated via Supercritical Carbon Dioxide Extraction
    AKAY H.A. El-Shemy, M.A.M. Aboul-Soud, A.A. Nassr-Allah, K.M. Aboul-Enein
    Current Medicinal Chemistry 17, 129-138 , 2010
    2010
    Citations: 250
  • Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients
    A Yagi, S Hegazy, A Kabbash, E Abd-El Wahab
    Saudi Pharmaceutical Journal 17 (3), 209-215 , 2009
    2009
    Citations: 144
  • Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from Aloe vera gel,
    TH Yagi A, Kabbash A, Mizuno K, Moustafa SM, Khalifa TI
    Planta Medica 69 (3), 269-71 , 2003
    2003
    Citations: 144
  • Monoamine oxidase inhibitors from Gentiana lutea
    H Haraguchi, Y Tanaka, A Kabbash, T Fujioka, T Ishizu, A Yagi
    Phytochemistry 65 (15), 2255-2260 , 2004
    2004
    Citations: 99
  • Purification, Characterization, Identification, and Anticancer Activity of a Circular Bacteriocin From Enterococcus thailandicus
    LA Al-Madboly, NM El-Deeb, A Kabbash, MA Nael, AM Kenawy, ...
    Frontiers in bioengineering and biotechnology 8, 450 , 2020
    2020
    Citations: 73
  • Antimicrobial and Immunomodulatory Activities of Flavonol Glycosides Isolated From Atriplex halimus L. Herb.
    M El-Aasr, A Kabbash, KAA El-Seoud, LA Al-Madboly, T Ikeda
    Journal of Pharmaceutical Sciences and Research 8 (10), 1159 , 2016
    2016
    Citations: 41
  • Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of Dioon spinulosum leaves Dyer Ex Eichler and its isolated secondary metabolites
    WA Negm, KA Abo El-Seoud, A Kabbash, AA Kassab, M El-Aasr
    Natural product research 35 (23), 5166-5176 , 2021
    2021
    Citations: 34
  • Chemical and Biological Investigation of Some Secondary Metabolites in Atriplex Halimus Growing in Egypt
    A Kabbash, N Shoeib
    Natural product communications 7 (11), 1934578X1200701114 , 2012
    2012
    Citations: 31
  • Chemotaxonomic study of the most abundant Egyptian sea-cucumbers using ultra-performance liquid chromatography (UPLC) coupled to high-resolution mass spectrometry (HRMS)
    NE Omran, HK Salem, SH Eissa, AM Kabbash, MA Kandeil, MA Salem
    Chemoecology 30 (1), 35-48 , 2020
    2020
    Citations: 26
  • A self-controlled single blinded clinical trial to evaluate oral lichen planus after topical treatment with Aloe vera
    K El-Soudany, A Yagi, A Kabbash
    Journal of Gastroenterology and Hepatology Research 2 (4), 503-7 , 2013
    2013
    Citations: 23
  • Elucidation of Natural Components of Gardenia thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease
    EM El-Shial, A Kabbash, M El-Aasr, OA El-Feky, SA El-Sherbeni
    Molecules 28 (2), 879 , 2023
    2023
    Citations: 19
  • Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a
    D Eliwa, MA Albadry, ARS Ibrahim, A Kabbash, K Meepagala, IA Khan, ...
    Phytochemistry 183, 112598 , 2021
    2021
    Citations: 19
  • Short chain fatty acids from fermentation by endophytic bacteria in Aloe vera leaf rind and gel
    A Yagi, A Kabbash, LA Al-Madboly
    Journal of Gastroenterology and Hepatology Research 5 (4), 2122-2124 , 2016
    2016
    Citations: 18
  • Ribosomal DNA sequence analysis of different geographically distributed Aloe vera plants: comparison with clonally regenerated plants.
    A Yagi, Y Sato, Y Miwa, A Kabbash, S Moustafa, K Shimomura, ...
    2006
    Citations: 18
  • Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect
    NGM Attallah, A Kabbash, WA Negm, E Elekhnawy, R Binsuwaidan, ...
    Pharmaceuticals 16 (2), 318 , 2023
    2023
    Citations: 17
  • Microbial transformation of curcumin and evaluation of the biological activities of the isolated metabolites
    AM Younis, ARS Ibrahim, SM Ibrahim, KA AboulSoud, AM Kabbash
    Journal of Pharmaceutical Sciences and Research 8 (10), 1169 , 2016
    2016
    Citations: 14
  • Efficacy of Aloe vera as a pulpotomy agent in children primary teeth: clinical and radiographic studies
    A Yagi, S Gonna, A Kabbash, N Ghoname
    Journal of Gastroenterology and Hepatology Research 8, 2946-2951 , 2019
    2019
    Citations: 13
  • In vitro characterization of inhibitors for lung A549 and leukemia K562 cell lines from fungal transformation of arecoline supported by in silico docking to M3-mAChR and ADME …
    AE Ragab, ET Badawy, SM Aboukhatwa, A Kabbash, KA Abo El-Seoud
    Pharmaceuticals 15 (10), 1171 , 2022
    2022
    Citations: 12
  • Investigation of the biological activity some gymnosperm plants belong to cycadales order
    W Negm, K Abo El-Seoud, A Kabbash, M El-Aasr
    Journal of Advanced Medical and Pharmaceutical Research 1 (1), 9-13 , 2020
    2020
    Citations: 12