COSTANZA MONTAGNA

Scopus Publications

The Bright and Dark Sides of Nitric Oxide in Neurodegenerative Diseases
Lucia Buccarello, Costanza Montagna, Sabina Di Matteo, Renata Mangione, Giuseppe Carota, Jay Sibbitts, Romana Jarosova, Susan M. Lunte, Giacomo Lazzarino, Giuseppe Caruso
Journal of Personalized Medicine, 2026
Nitric oxide (NO) plays an important role in neuronal communication, synaptic plasticity and vascular regulation. Due to its important function in neuronal homeostasis, NO imbalance is associated with neurodegeneration. Specifically, in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD) and frontotemporal lobar degeneration (FTLD), an excessive amount of NO, mostly produced by inducible NO synthase (iNOS), reacts with superoxide to form peroxynitrite, driving oxidative/nitrosative stress, mitochondrial dysfunction, and aberrant protein modifications. In AD, NO dysregulation promotes amyloid-β (Aβ) accumulation, tau hyperphosphorylation and synaptic loss, creating a self-perpetuating cycle of neuronal damage. NO’s dual role, protective at physiological levels but harmful if overproduced, underscores the therapeutic potential of antioxidant compounds that restore the balance of NO/NOS (especially iNOS) while preserving physiological functions. However, despite the emerging role of antioxidant-based therapeutic approaches, clinical translation is limited by the complexity of NO signaling and the absence of safe, specific NOS inhibitors. By targeting the molecular switch from protective to toxic, NO activity may offer new personalized treatment avenues for neurodegenerative diseases.
Circulating Neuregulin-4 tracks acute hyperbaric and workload stress in human divers, preceding oxidative injury markers
Claudia Di Biagio, Paola Giglio, Matteo Bordi, Giovanni Larotondo, Riccardo Turchi, Luigi Fattorini, Enrico Marchetti, Daniele Lettieri-Barbato, Costanza Montagna, Giuseppe Filomeni, Katia Aquilano
Free Radical Biology and Medicine, 2026
Acute hyperbaric stress during diving combines increased ambient pressure, hyperoxia, hemodynamic shifts, and often muscular workload. Identifying real-time blood biomarkers sensitive to these individual and combined physiological loads remains a challenge. Neuregulin-4 (NRG4), an adipokine secreted by thermogenic and subcutaneous white fat, responds to adrenergic stimulation and modulates redox homeostasis. We investigated NRG4 dynamics alongside oxidative protein carbonyls in divers in warm (thermoneutral) water (∼33.6 °C ambient water temperature) to avoid cold stress. Two field campaigns were conducted: a first depth response campaign involved divers exposed to 20, 30, or 40 m on separate days, without exercise, with serial blood sampling; a second physical effort study involved 15 m dives with or without slow-pedalling exercise. Serum NRG4 was quantified by ELISA and expressed as log 2 fold change relative to baseline. Protein carbonyls were measured as markers of oxidative damage. Statistical analysis employed single-sample tests and false-discovery rate control. NRG4 exhibited a robust early increase at 30 m, significant after correction, and nominal elevations at 40 m, but remained unchanged at 20 m. Exercise at 15 m triggered a significant early NRG4 rise absent during passive dives at the same depth. Protein carbonyls remained stable in early post-emersion windows but increased significantly at later time points (180- and 240-min post-emersion) following dives to 40 m, indicating delayed oxidative burden. Our findings position NRG4 as a fast, pressure- and workload-responsive biomarker of diving stress, temporally distinct from classical oxidative injury markers that manifest later. This temporal dissociation underscores the potential of NRG4 for real-time monitoring of acute physiological load during hyperbaric exposure, integrating pressure- and workload-related stressors. Temporal uncoupling of endocrine and oxidative stress responses during diving. During thermoneutral dives, NRG4 rises rapidly after hyperbaric exposure, while oxidative protein carbonyls increase later. This sequence identifies NRG4 as an early marker of acute physiological stress preceding oxidative injury. • Thermoneutral diving elicits early NRG4 rises linked to ambient pressure • NRG4 peaks within 0–90 min post-emersion, indicating a rapid endocrine response • Oxidative protein carbonyls increase later, peaking at 180–240 min at 40 m • Exercise at shallow depth reproduces the early NRG4 rise seen at 30–40 m • NRG4 marks acute hyperbaric load before oxidative stress becomes evident
“Feeding the Rhythm”—Effects of Food and Nutrients on Daily Cortisol Secretion: From Molecular Mechanisms to Clinical Impact
Rosa Maria Paragliola, Marco Marchetti, Costanza Montagna, Salvatore Maria Corsello, Gianfranco Peluso
International Journal of Molecular Sciences, 2025
Daily rhythms define physical, mental, and behavioral changes that the body experiences over a 24 h cycle. The light–dark cycle plays a crucial role in regulating daily rhythms, but other factors such as food intake, stress, and physical activity also affect them. Cortisol secretion exhibits one of the largest endocrine amplitudes, with an early morning peak and late-evening nadir driven by the suprachiasmatic nucleus and hypothalamus–pituitary–adrenal axis, representing the most robust endocrine output of the circadian system. Beyond photic cues, feeding is a potent non-photic zeitgeber that entrains peripheral oscillators and dynamically shapes cortisol secretion. This narrative review aims to explore the effect of feeding in modulating cortisol secretion. The misalignment of the daily cortisol-secretion rhythm, with blunted cortisol awakening response and elevated evening levels, leads to metabolic syndrome, psychiatric disorders, shift work, and jet lag. In endogenous hypercortisolism, the loss of rhythmicity rather than absolute exposure best predicts risk. Therefore, we discuss practical nutritional tools as opportunities to partially restore rhythmic hypothalamus–pituitary–adrenal axis physiology.
Duchenne Muscular Dystrophy: Integrating Current Clinical Practice with Future Therapeutic and Diagnostic Horizons
Costanza Montagna, Emiliano Maiani, Luisa Pieroni, Silvia Consalvi
International Journal of Molecular Sciences, 2025
Duchenne muscular dystrophy (DMD) is a severe X-linked disorder characterized by progressive muscle degeneration due to mutations in the dystrophin gene. Despite major advancements in understanding its pathophysiology, there is still no curative treatment. This review provides an up-to-date overview of current and emerging therapeutic approaches—including antisense oligonucleotides, gene therapy, gene editing, corticosteroids, and histone deacetylases(HDAC) inhibitors—aimed at restoring dystrophin expression or mitigating disease progression. Special emphasis is placed on the importance of early diagnosis, the utility of genetic screening, and the innovations in pre-and post-natal testing. As the field advances toward personalized medicine, the integration of precision therapies with cutting-edge diagnostic technologies promises to improve both prognosis and quality of life for individuals with DMD.
GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation
Salvatore Rizza, Luca Di Leo, Chiara Pecorari, Paola Giglio, Fiorella Faienza, Costanza Montagna, Emiliano Maiani, Michele Puglia, Francesca M. Bosisio, Trine Skov Petersen, Lin Lin, Vendela Rissler, Juan Salamanca Viloria, Yonglun Luo, Elena Papaleo, Daniela De Zio, Blagoy Blagoev, Giuseppe Filomeni
Cell Reports, 2023
Nitric oxide (NO) production in the tumor microenvironment is a common element in cancer. S-nitrosylation, the post-translational modification of cysteines by NO, is emerging as a key transduction mechanism sustaining tumorigenesis. However, most oncoproteins that are regulated by S-nitrosylation are still unknown. Here we show that S-nitrosoglutathione reductase (GSNOR), the enzyme that deactivates S-nitrosylation, is hypo-expressed in several human malignancies. Using multiple tumor models, we demonstrate that GSNOR deficiency induces S-nitrosylation of focal adhesion kinase 1 (FAK1) at C658. This event enhances FAK1 autophosphorylation and sustains tumorigenicity by providing cancer cells with the ability to survive in suspension (evade anoikis). In line with these results, GSNOR-deficient tumor models are highly susceptible to treatment with FAK1 inhibitors. Altogether, our findings advance our understanding of the oncogenic role of S-nitrosylation, define GSNOR as a tumor suppressor, and point to GSNOR hypo-expression as a therapeutically exploitable vulnerability in cancer.
Looking at denitrosylation to understand the myogenesis gone awry theory of rhabdomyosarcoma
Costanza Montagna, Giuseppe Filomeni
Nitric Oxide Biology and Chemistry, 2022
Autophagy guards tendon homeostasis
Costanza Montagna, Rene B. Svensson, Monika L. Bayer, Salvatore Rizza, Emiliano Maiani, Ching-Yan Chloé Yeung, Giuseppe Filomeni, Michael Kjær
Cell Death and Disease, 2022
Tendons are vital collagen-dense specialized connective tissues transducing the force from skeletal muscle to the bone, thus enabling movement of the human body. Tendon cells adjust matrix turnover in response to physiological tissue loading and pathological overloading (tendinopathy). Nevertheless, the regulation of tendon matrix quality control is still poorly understood and the pathogenesis of tendinopathy is presently unsolved. Autophagy, the major mechanism of degradation and recycling of cellular components, plays a fundamental role in the homeostasis of several tissues. Here, we investigate the contribution of autophagy to human tendons’ physiology, and we provide in vivo evidence that it is an active process in human tendon tissue. We show that selective autophagy of the endoplasmic reticulum (ER-phagy), regulates the secretion of type I procollagen (PC1), the major component of tendon extracellular matrix. Pharmacological activation of autophagy by inhibition of mTOR pathway alters the ultrastructural morphology of three-dimensional tissue-engineered tendons, shifting collagen fibrils size distribution. Moreover, autophagy induction negatively affects the biomechanical properties of the tissue-engineered tendons, causing a reduction in mechanical strength under tensile force. Overall, our results provide the first evidence that autophagy regulates tendon homeostasis by controlling PC1 quality control, thus potentially playing a role in the development of injured tendons.
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
Emiliano Maiani, Giacomo Milletti, Francesca Nazio, Søs Grønbæk Holdgaard, Jirina Bartkova, Salvatore Rizza, Valentina Cianfanelli, Mar Lorente, Daniele Simoneschi, Miriam Di Marco, Pasquale D’Acunzo, Luca Di Leo, Rikke Rasmussen, Costanza Montagna, Marilena Raciti, Cristiano De Stefanis, Estibaliz Gabicagogeascoa, Gergely Rona, Nélida Salvador, Emanuela Pupo, Joanna Maria Merchut-Maya, Colin J. Daniel, Marianna Carinci, Valeriana Cesarini, Alfie O’sullivan, Yeon-Tae Jeong, Matteo Bordi, Francesco Russo, Silvia Campello, Angela Gallo, Giuseppe Filomeni, Letizia Lanzetti, Rosalie C. Sears, Petra Hamerlik, Armando Bartolazzi, Robert E. Hynds, David R. Pearce, Charles Swanton, Michele Pagano, Guillermo Velasco, Elena Papaleo, Daniela De Zio, Apolinar Maya-Mendoza, Franco Locatelli, Jiri Bartek, Francesco Cecconi
Nature, 2021
Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to replicate the genome is controlled by two major signalling pathways that act in parallel-the MYC pathway and the cyclin D-cyclin-dependent kinase (CDK)-retinoblastoma protein (RB) pathway1,2. Both MYC and the cyclin D-CDK-RB axis are commonly deregulated in cancer, and this is associated with increased genomic instability. The autophagic tumour-suppressor protein AMBRA1 has been linked to the control of cell proliferation, but the underlying molecular mechanisms remain poorly understood. Here we show that AMBRA1 is an upstream master regulator of the transition from G1 to S phase and thereby prevents replication stress. Using a combination of cell and molecular approaches and in vivo models, we reveal that AMBRA1 regulates the abundance of D-type cyclins by mediating their degradation. Furthermore, by controlling the transition from G1 to S phase, AMBRA1 helps to maintain genomic integrity during DNA replication, which counteracts developmental abnormalities and tumour growth. Finally, we identify the CHK1 kinase as a potential therapeutic target in AMBRA1-deficient tumours. These results advance our understanding of the control of replication-phase entry and genomic integrity, and identify the AMBRA1-cyclin D pathway as a crucial cell-cycle-regulatory mechanism that is deeply interconnected with genomic stability in embryonic development and tumorigenesis.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Abdelaziz, Sara Abdelfatah, M. Abdellatif, A. Abdoli, S. Abel, H. Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, I. E. Adamopoulos, K. Adeli, T. Adolph, A. Adornetto, E. Aflaki, G. Agam, A. Agarwal, B. Aggarwal, M. Agnello, P. Agostinis, Javed N Agrewala, Alexander Agrotis, P. Aguilar, S. T. Ahmad, Z. Ahmed, Ulises Ahumada-Castro, S. Aits, S. Aizawa, Y. Akkoç, Tonia Akoumianaki, Hafize Aysin Akpinar, Ahmed M Al-Abd, Lina Al-Akra, Abeer Al-Gharaibeh, M. Alaoui-Jamali, S. Alberti, Elísabet Alcocer-Gómez, C. Alessandri, Muhammad Ali, M. A. Alim Al-Bari, Saeb H. Aliwaini, J. Alizadeh, Eugènia Almacellas, Alexandru Almasan, A. Alonso, G. Alonso, N. Altan-Bonnet, D. Altieri, Elida M. C. Álvarez, S. Alves, C. Alvès da Costa, Mazen M Alzaharna, M. Amadio, C. Amantini, Cristina Amaral, S. Ambrosio, A. Amer, Veena Ammanathan, Z. An, S. U. Andersen, S. Andrabi, Magaiver Andrade-Silva, A. Andres, S. Angelini, D. Ann, Uche C. Anozie, M. Ansari, Pedro Antas, Adam Antebi, Zuriñe Antón, T. Anwar, L. Apetoh, N. Apostolova, T. Araki, Yasuhiro Araki, Kohei Arasaki, W. Araújo, J. Araya, C. Arden, M. Arevalo, S. Arguelles, E. Arias, Jyothi Arikkath, H. Arimoto, Aileen R. Ariosa, D. Armstrong-James, Laétitia Arnauné-Pelloquin, Ángeles Aroca, D. Arroyo, I. Arsov, R. Artero, D. Asaro, M. Aschner, Milad Ashrafizadeh, O. Ashur-Fabian, A. Atanasov, Alicia K. Au, P. Auberger, H. Auner, L. Aurelian, R. Autelli, L. Avagliano, Y. Ávalos, S. Aveic, C. Aveleira, Tamar Avin-Wittenberg, Y. Aydin, S. Ayton, S. Ayyadevara, M. Azzopardi, M. Baba, J. Backer, Steven K. Backues, Dong-Hun Bae, O. Bae, Soo Han Bae, E. H. Baehrecke, A. Baek, Seung-Hoon Baek, Sung Wook Baek, G. Bagetta, A. Bagniewska-Zadworna, H. Bai, J. Bai, X. Bai, Yidong Bai, N. Bairagi, S. Baksi, T. Balbi, C. Baldari, W. Balduini, A. Ballabio, M. Ballester, S. Balazadeh, R. Balzan, R. Bandopadhyay, S. Banerjee, Santanu Banerjee, Ágnes Bánréti, Yan Bao, M. Baptista, A. Baracca, C. Barbati, A. Bargiela, D. Barilà, Peter G Barlow, S. Barmada, E. Barreiro, G. Barreto, J. Bartek, Bonnie Bartel, A. Bartolomé, Gaurav Barve, S. Basagoudanavar, D. Bassham, R. Bast, A. Basu, H. Batoko, Isabella Batten, E. Baulieu, B. L. Baumgarner, J. Bayry, Rupert Beale, I. Beau, Florian Beaumatin, L. G. Bechara, G. Beck, M. Beers, J. Begun, C. Behrends, G. Behrens, R. Bei, E. Bejarano, S. Bel, C. Behl, Amine Belaid, Naïma Belgareh-Touzé, C. Bellarosa, F. Belleudi, Melissa Belló Pérez, Raquel Bello-Morales, J. O. Beltran, Sebastián Beltrán, D. Benbrook, Mykolas Bendorius, B. Benitez, Irene Benito-Cuesta, Julien Bensalem, M. Berchtold, S. Berezowska, D. Bergamaschi, Matteo Bergami, A. Bergmann, L. Berliocchi, C. Berlioz-Torrent, Amélie Bernard, L. Berthoux, C. Besirli, Sébastien Besteiro, V. Betin, R. Beyaert, Jelena S. Bezbradica, Kiran Bhaskar, I. Bhatia-Kiššová, R. Bhattacharya, S. Bhattacharya, S. Bhattacharyya, M. Bhuiyan, S. Bhutia, Lanrong Bi, X. Bi, T. Biden, K. Bijian, Viktor Billes, N. Binart, C. Bincoletto, Å. B. Birgisdottir, G. Bjørkøy, G. Blanco, A. Blas-García, J. Błasiak, R. Blomgran, K. Blomgren, J. Blum, Emilio Boada-Romero, Mirta Boban, K. Boesze-Battaglia, P. Boeuf, Barry Boland, P. Bomont, P. Bonaldo, S. Bonam, L. Bonfili, J. Bonifacino, B. Boone, M. Bootman, M. Bordi, C. Borner, Beat C Bornhauser, G. Borthakur, J. Bosch, S. Bose, L. Botana, J. Botas, C. Boulanger, M. Boulton, Mathieu Bourdenx, Benjamin Bourgeois, N. Bourke, G. Bousquet, P. Boya, P. Bozhkov, Luiz H. M. Bozi, T. Bozkurt, Doug E. Brackney, C. Brandts, Ralf J. Braun, G. Braus, R. Bravo-Sagua, J. M. Bravo-San Pedro, P. Brest, M. Bringer, Alfredo Briones-Herrera, V. Broaddus, P. Brodersen, J. Brodsky, S. L. Brody, P. Bronson, J. Bronstein, C. N. Brown, R. Brown, P. Brum, J. Brumell, N. Brunetti-Pierri, Daniele Bruno, R. Bryson-Richardson, C. Bucci, C. Buchrieser, M. Bueno, L. E. Buitrago-Molina, Simone Buraschi, S. Buch, J. Buchan, E. M. Buckingham, Hikmet Budak, Mauricio Budini, G. Bultynck, F. Burada, J. Burgoyne, M. I. Burón, V. Bustos, S. Büttner, Elena Butturini, A. Byrd, I. Cabas, Sandra Cabrera-Benítez, K. Cadwell, Jingjing Cai, L. Cai, Qian Cai, M. Cairó, J. A. Calbet, G. Caldwell, K. Caldwell, J. Call, R. Calvani, A. Calvo, Miguel Calvo-Rubio Barrera, N. O. Câmara, J. Camonis, N. Camougrand, M. Campanella, E. Campbell, François-Xavier Campbell-Valois, Silvia Campello, I. Campesi, J. C. Campos, O. Camuzard, J. Cancino, Danilo Candido de Almeida, L. Canesi, I. Caniggia, B. Canonico, C. Cantí, B. Cao, M. Caraglia, B. Caramés, Evie H Carchman, Elena Cardenal-Muñoz, C. Cárdenas, L. Cárdenas, S. Cardoso, J. Carew, G. F. Carle, Gillian Carleton, S. Carloni, D. Carmona-Gutierrez, L. Carneiro, O. Carnevali, Julian M Carosi, S. Carra, A. Carrier, L. Carrier, B. Carroll, A. Carter, A. N. Carvalho, M. Casanova, C. Casas, J. Casas, C. Cassioli, Eliseo F. Castillo, Karen Castillo, S. Castillo-Lluva, F. Castoldi, M. Castori, A. Castro, Margarida Castro-Caldas, J. Castro-Hernández, S. Castro-Obregón, S. D. Catz, C. Cavadas, F. Cavaliere, G. Cavallini, M. Cavinato, M. L. Cayuela, Paula Cebollada Rica, V. Cecarini, Francesco Cecconi, M. Cechowska-Pasko, S. Cenci, V. Ceperuelo-Mallafré, J. Cerqueira, J. Cerutti, D. Cervia, V. Cetintas, S. Cetrullo, Han-Jung Chae, A. Chagin, C. Chai, G. Chakrabarti, O. Chakrabarti, T. Chakraborty, T. Chakraborty, M. Chami, G. Chamilos, D. Chan, E. Chan, E. Chan, H. C. Chan, Helen Y L Chan, Hung Chan, M. Chan, Yau Kei Chan, P. K. Chandra, Chih-Peng Chang, Chunmei Chang, Hao-Chun Chang, Kai Chang, J. Chao, T. Chapman, N. Charlet-Berguerand, S. Chatterjee, S. K. Chaube, Anu Chaudhary, S. Chauhan, E. Chaum, F. Checler, M. E. Cheetham, Chang-Shi Chen, G. Chen, Jian-Fu Chen, Liam Chen, L. Chen, L. Chen, Mingliang Chen, Mu-Kuan Chen, Ning Chen, Quan Chen, Ruey-Hwa Chen, S. Chen, Weiqian Chen, Weiqiang Chen, Xinming Chen, Xiongwen Chen, X. Chen, Y. Chen, Y. Chen, Y. Chen, Yongqiang Chen, Y. Chen, Yue-Qin Chen, Z. Chen, Z. Chen, Z. Chen, Z. Chen, Zhixiang Chen, Hanhua Cheng, J. Cheng, Shi-Yuan Cheng, W. Cheng, Xiaodong Cheng, Xiu-Tang Cheng, Yiyun Cheng, Z. Cheng, Zhong Chen, Heesun Cheong, J. K. Cheong, B. Chernyak, S. Cherry, Chi Wo Cheung, Chun In Cheung, King-Ho Cheung, E. Chevet, Richard J. Chi, A. Chiang, F. Chiaradonna, R. Chiarelli, M. Chiariello, Nathalia Chica, S. Chiocca, M. Chiong, S. Chiou, Abhilash I. Chiramel, V. Chiurchiù, Dong-Hyung Cho, S. Choe, Augustine M K Choi, M. Choi, K. R. Choudhury, Norman S. Chow, C. Chu, Jason P. Chua, J. J. Chua, Hyewon Chung, K. Chung, S. Chung, S. Chung, Y. Chung, V. Cianfanelli, I. Ciechomska, M. Cifuentes, L. Cinque, S. Çırak, M. Cirone, M. Clague, R. Clarke, E. Clementi, E. Coccia, P. Codogno, E. Cohen, M. Cohen, T. Colasanti, Fiorella Colasuonno, R. Colbert, A. Colell, M. Čolić, N. Coll, M. Collins, M. Colombo, Daniel A Colón-Ramos, L. Combaret, S. Comincini, M. Cominetti, Antonella Consiglio, A. Conte, F. Conti, Viorica Raluca Contu, M. Cookson, K. Coombs, I. Coppens, M. Corasaniti, Dale P Corkery, N. Cordes, K. Cortese, Maria do Carmo Costa, Sarah Costantino, P. Costelli, A. Coto-Montes, P. Crack, J. L. Crespo, Alfredo Criollo, Valeria Crippa, Riccardo Cristofani, Tamás Csizmadia, A. Cuadrado, B. Cui, J. Cui, Yixian Cui, Y. Cui, Emmanuel Culetto, A. Cumino, Andrey V. Cybulsky, M. Czaja, S. Czuczwar, S. D’Adamo, M. D’Amelio, D. D'Arcangelo, A. D'Lugos, G. D'Orazi, J. A. da Silva, H. S. Dafsari, R. Dagda, Yasin F. Dagdas, M. Daglia, Xiao-xia Dai, Y. Dai, Y. Dai, J. Dal Col, Paul Dalhaimer, L. Dalla Valle, T. Dallenga, G. Dalmasso, M. Damme, Ilaria Dando, N. Dantuma, April L Darling, H. Das, S. Dasarathy, S. Dasari, S. Dash, O. Daumke, Adrian N. Dauphinee, J. S. Davies, Valeria A. Dávila, R. Davis, T. Davis, S. Dayalan Naidu, F. De Amicis, K. De Bosscher, F. De Felice, L. De Franceschi, Chiara De Leonibus, M. G. de Mattos Barbosa, G. D. De Meyer, Angelo De Milito, C. De Nunzio, C. de Palma, M. De Santi, C. De Virgilio, D. De Zio, Jayanta Debnath, B. DeBosch, Jean-Paul Decuypere, Mark A Deehan, Gianluca Deflorian, J. DeGregori, B. Dehay, G. Del Rio, J. Delaney, L. Delbridge, Elizabeth Delorme-Axford, M. V. Delpino, F. Demarchi, Vilma Dembitz, Nicholas D Demers, Hong-bin Deng, Z. Deng, J. Dengjel, P. Dent, D. Denton, M. DePamphilis, C. Der, V. Deretic, A. Descoteaux, Laura Devis, Sushil Devkota, O. Devuyst, G. Dewson, Mahendiran Dharmasivam, Rohan Dhiman, D. di Bernardo, M. Di Cristina, F. Di Domenico, P. Di Fazio, A. Di Fonzo, G. Di Guardo, G. M. Di Guglielmo, Luca Di Leo, Chiara Di Malta, Alessia Di Nardo, M. Di Rienzo, F. Di Sano, G. Diallinas, J. Diao, Guillermo Díaz-Araya, I. Díaz-Laviada, J. M. Dickinson, M. Diederich, M. Dieudé, I. Dikic, S. Ding, Wen-Xing Ding, L. Dini, Jelena Dinić, M. Dinić, A. Dinkova-Kostova, Marc S. Dionne, J. Distler, A. Diwan, I. Dixon, M. Djavaheri-Mergny, I. Dobrinski, O. Dobrovinskaya, Radek Dobrowolski, R. Dobson, Jelena Đokić, Serap Dokmeci Emre, M. Donadelli, Bo Dong, X. Dong, Zhiwu Dong, G. Dorn Ii, Volker Dotsch, Hu Dou, J. Dou, Moataz Dowaidar, S. Dridi, L. Drucker, Ailian Du, C. Du, G. Du, Hai-Ning Du, L. Du, André du Toit, S. Duan, Xiaoqiong Duan, S. P. Duarte, A. Dubrovska, E. Dunlop, N. Dupont, R. Durán, B. Dwarakanath, S. Dyshlovoy, D. Ebrahimi-Fakhari, L. Eckhart, C. Edelstein, Thomas Efferth, E. Eftekharpour, L. Eichinger, N. Eid, Tobias Eisenberg, N. Eissa, S. Eissa, M. Ejarque, Abdeljabar El Andaloussi, Nazira El-Hage, S. El-Naggar, A. M. Eleuteri, E. S. El-Shafey, M. Elgendy, A. Eliopoulos, M. M. Elizalde, Philip M Elks, Hans-Peter Elsasser, E. Elsherbiny, B. Emerling, N. C. Emre, C. Eng, N. Engedal, A. Engelbrecht, Agnete S T Engelsen, J. Enserink, R. Escalante, A. Esclatine, Mafalda Escobar-Henriques, Eeva-Liisa Eskelinen, L. Espert, Makandjou-Ola Eusebio, G. Fabriàs, C. Fabrizi, A. Facchiano, F. Facchiano, B. Fadeel, C. Fader, Alex C. Faesen, W. D. Fairlie, A. Falco, Bjorn H Falkenburger, Daping Fan, J. Fan, Yanbo Fan, E. Fang, Y. Fang, Yognqi Fang, M. Fanto, Tamar Farfel-Becker, M. Faure, G. Fazeli, A. Fedele, A. Feldman, D. Feng, Jiachun Feng, Lifeng Feng, Yibin Feng, Yuchen Feng, Wei Feng, Thais Fenz Araujo, T. Ferguson, Á. Fernández, J. Fernández-Checa, S. Fernández-Veledo, A. Fernie, A. Ferrante, Alessandra Ferraresi, M. F. Ferrari, J. Ferreira, S. Ferro-Novick, A. Figueras, R. Filadi, N. Filigheddu, E. Filippi-Chiela, G. Filomeni, G. Fimia, V. Fineschi, F. Finetti, S. Finkbeiner, E. Fisher, P. Fisher, F. Flamigni, S. J. Fliesler, T. Flo, Ida Florance, Oliver Florey, T. Florio, E. Fodor, Carlo Follo, E. Fon, A. Forlino, F. Fornai, P. Fortini, Anna Fracassi, A. Fraldi, B. Franco, R. Franco, F. Franconi, L. Frankel, S. Friedman, L. Fröhlich, G. Frühbeck, J. Fuentes, Yukio Fujiki, Naonobu Fujita, Yuuki Fujiwara, M. Fukuda, S. Fulda, L. Furic, N. Furuya, C. Fusco, Michaela U. Gack, Lidia Gaffke, S. Galadari, A. Galasso, M. F. Galindo, Sachith Gallolu Kankanamalage, L. Galluzzi, V. Galy, Noor Gammoh, B. Gan, I. Ganley, F. Gao, H. Gao, Minghui Gao, P. Gao, Shou-Jiang Gao, W. Gao, Xiaobo Gao, Ana Garcera, M. N. GarcÍa, V. García, F. García-del Portillo, Vega García-Escudero, A. Garcia-Garcia, Marina García-Macia, Diana García-Moreno, C. Garcia-Ruiz, Patricia García-Sanz, Abhishek D Garg, R. Gargini, T. Garofalo, R. Garry, N. Gassen, D. Gatica, Liang Ge, W. Ge, Ruth Geiss-Friedlander, C. Gelfi, P. Genschik, I. Gentle, Valeria Gerbino, Christoph Gerhardt, Kyla Germain, M. Germain, D. A. Gewirtz, Elham Ghasemipour Afshar, Saeid Ghavami, A. Ghigo, M. Ghosh, G. Giamas, C. Giampietri, A. Giatromanolaki, G. Gibson, S. Gibson, V. Ginet, E. Giniger, C. Giorgi, Henrique Girão, S. Girardin, M. Giridharan, S. Giuliano, C. Giulivi, S. Giuriato, J. Giustiniani, A. Gluschko, V. Goder, A. Goginashvili, J. Gołąb, D. Goldstone, A. Golebiewska, L. R. Gomes, R. Gomez, R. Gómez-Sánchez, Maria Catalina Gomez-Puerto, Raquel Gómez-Sintes, Qingqiu Gong, Félix M. Goñi, J. González-Gallego, T. Gonzalez-Hernandez, R. González-Polo, J. González-Reyes, P. González-Rodríguez, I. Goping, M. Gorbatyuk, N. Gorbunov, K. Görgülü, R. M. Gorojod, S. Gorski, S. Goruppi, C. Gotor, R. Gottlieb, I. Gozes, D. Gozuacik, M. Graef, M. Gräler, V. Granatiero, D. Grasso, J. P. Gray, D. Green, Alexander. Greenhough, S. Gregory, Edward F Griffin, M. Grinstaff, F. Gros, C. Grose, Angelina S Gross, F. Gruber, Paolo Grumati, T. Grune, Xueyan Gu, J. Guan, Carlos M Guardia, K. Guda, F. Guerra, C. Guerri, P. Guha, C. Guillén, Shashi Gujar, A. Gukovskaya, I. Gukovsky, J. Gunst, A. Günther, A. Guntur, Chuanyong Guo, C. Guo, H. Guo, L. Guo, M. Guo, P. Gupta, S. Gupta, Swapnil Gupta, V. Gupta, V. Gupta, Å. Gustafsson, D. Gutterman, R. H. B., A. Haapasalo, J. Haber, Aleksandra Hać, S. Hadano, Anders Hafrén, M. Haidar, B. Hall, G. Halldén, A. Hamacher-Brady, A. Hamann, M. Hamasaki, W. Han, Malene Hansen, P. Hanson, Zijian Hao, M. Harada, L. Harhaji-Trajković, N. Hariharan, N. Haroon, J. Harris, T. Hasegawa, Noor Hasima Nagoor, J. Haspel, V. Haucke, Wayne D Hawkins, B. Hay, Cole M. Haynes, S. Hayrabedyan, T. Hays, C. He, Q. He, R. He, You-Wen He, Y. He, Yasser Heakal, A. M. Heberle, J. Hejtmancik, G. Helgason, Vanessa Henkel, Marc Herb, A. Hergovich, A. Herman-Antosiewicz, A. Hernández, C. Hernández, Sergio Hernández-Díaz, V. Hernández-Gea, Amaury Herpin, J. Herreros, Javier H. Hervás, Daniel Hesselson, Claudio Hetz, V. Heussler, Y. Higuchi, Sabine Hilfiker, J. Hill, W. S. Hlavacek, Emmanuel A Ho, Idy H. T. Ho, P. Ho, S. Ho, Wan Yun Ho, G. A. Hobbs, M. Hochstrasser, Peter H M Hoet, D. Hofius, P. Hofman, A. Hoehn, Carina I. Holmberg, J. R. Hombrebueno, Chang-Won Hong Yi-Ren Hong, L. Hooper, T. Hoppe, Rastislav Horos, Y. Hoshida, I-Lun Hsin, H. Hsu, B. Hu, D. Hu, Li-Fang Hu, M. C. Hu, R. Hu, W. Hu, Y. Hu, Zhuo-wei Hu, Fang Hua, J. Hua, Y. Hua, C. Huan, C. Huang, C. Huang, Chuanxin Huang, C. Huang, H. Huang, K. Huang, M. L. Huang, Rui Huang, S. Huang, Tianzhi Huang, Xing Huang, Y. J. Huang, T. Huber, Virginie Hubert, Christian A Hubner, S. Hughes, W. E. Hughes, M. Humbert, G. Hummer, J. Hurley, S. Hussain, Salik Hussain, Patrick J Hussey, M. Hutabarat, Hui-Yun Hwang, S. Hwang, A. Ieni, F. Ikeda, Y. Imagawa, Y. Imai, C. Imbriano, M. Imoto, D. Inman, K. Inoki, J. Iovanna, R. Iozzo, G. Ippolito, J. Irazoqui, P. Iribarren, M. Ishaq., M. Ishikawa, Nestor Ishimwe, C. Isidoro, Nahed Ismail, S. Issazadeh-Navikas, Eisuke Itakura, D. Ito, D. Ivankovic, S. Ivanova, A. Iyer, J. Izquierdo, M. Izumi, M. Jäättelä, M. Jabir, W. T. Jackson, N. Jacobo-Herrera, Anne-Claire Jacomin, Elise Jacquin, Pooja Jadiya, H. Jaeschke, C. Jagannath, A. Jakobi, J. Jakobsson, B. Janji, P. Jansen-Duerr, P. Jansson, Jonathan Jantsch, S. Januszewski, Alagie Jassey, S. Jean, Hélène Jeltsch-David, P. Jendelová, Andreas Jenny, T. E. Jensen, N. Jessen, J. Jewell, J. Ji, L. Jia, Rui Jia, L. Jiang, Qing Jiang, R. Jiang, Teng Jiang, X. Jiang, Y. Jiang, M. Jimenez-Sanchez, E. Jin, F. Jin, Hongchuan Jin, Li Jin, Luqi Jin, Meiyan Jin, S. Jin, Eun-Kyeong Jo, C. Joffre, T. Johansen, G. V. Johnson, S. Johnston, E. Jokitalo, M. Jolly, L. Joosten, J. Jordán, B. Joseph, Dianwen Ju, J. Ju, Jingfang Ju, Esmeralda Juárez, Delphine Judith, G. Juhász, Y. Jun, C. H. Jung, S. Jung, Y. K. Jung, H. Jungbluth, J. Jungverdorben, S. Just, K. Kaarniranta, A. Kaasik, T. Kabuta, Daniel Kaganovich, A. Kahana, R. Kain, Shinjo Kajimura, M. Kalamvoki, Manjula Kalia, Danuta S Kalinowski, N. Kaludercic, Ioanna Kalvari, J. Kaminska, V. Kaminskyy, H. Kanamori, Keizo Kanasaki, Chanhee Kang, Rui Kang, Sang Mo Kang, S. Kaniyappan, T. Kanki, Thirumala-Devi Kanneganti, A. Kanthasamy, A. Kanthasamy, M. Kantorow, O. Kapuy, M. Karamouzis, Md. Razaul Karim, P. Karmakar, R. Katare, Masaru Kato, S. Kaufmann, A. Kauppinen, G. Kaushal, S. Kaushik, K. Kawasaki, K. Kazan, Po-Yuan Ke, Damien J Keating, U. Keber, J. Kehrl, K. Keller, Christian W. Keller, J. Kemper, C. Kenific, O. Kepp, S. Kermorgant, A. Kern, R. Ketteler, T. Keulers, Boris Khalfin, H. Khalil, B. Khambu, Shahid Y. Khan, V. Khandelwal, R. Khandia, Widuri Kho, Noopur V Khobrekar, Sataree Khuansuwan, Mukhran Khundadze, Samuel A Killackey, D. Kim, Deok Yeong Kim, Dohyung Kim, Dong-Eun Kim, E. Kim, Eun-kyoung Kim, H. Kim, H. Kim, Hyung-Ryong Kim, Jeong Yub Kim, J. Kim, Jin-Hoi Kim, J. Kim, Ju Seok Kim, K. Kim, P. K. Kim, Seong-Jun Kim, S. Kimball, A. Kimchi, A. Kimmelman, T. Kimura, M. A. King, K. Kinghorn, Conan G. Kinsey, V. Kirkin, L. Kirshenbaum, S. Kiselev, S. Kishi, K. Kitamoto, Y. Kitaoka, K. Kitazato, R. N. Kitsis, J. Kittler, Ole Kjaerulff, P. Klein, T. Klopstock, J. Klucken, Helene Knævelsrud, Roland L. Knorr, B. Ko, Fred C Ko, Jiunn-Liang Ko, H. Kobayashi, S. Kobayashi, Ina Koch, J. Koch, U. Koenig, D. Kögel, Y. Koh, M. Koike, S. Kohlwein, N. M. Kocaturk, M. Komatsu, J. König, T. Kôno, B. Kopp, T. Korcsmáros, Gözde Korkmaz, Viktor I. Korolchuk, Mónica Suárez Korsnes, A. Koskela, J. Kota, Y. Kotake, M. Kotler, Y. Kou, M. Koukourakis, Evangelos Koustas, A. Kovács, Tibor Kovács, D. Koya, T. Kozako, C. Kraft, D. Krainc, H. Krämer, A. Krasnodembskaya, C. Kretz-Remy, G. Kroemer, N. Ktistakis, K. Kuchitsu, Sabine Kuenen, L. Kuerschner, Thomas L Kukar, A. Kumar, A. Kumar, D. Kumar, D. Kumar, S. Kumar, S. Kume, Caroline Kumsta, C. N. Kundu, M. Kundu, Ajaikumar B. Kunnumakkara, L. Kurgan, T. Kutateladze, O. Kutlu, S. Kwak, H. Kwon, T. Kwon, Yong Eok Kwon, Irene Kyrmizi, A. L. La Spada, P. Labonté, S. Ladoire, Ilaria Laface, F. Lafont, D. Lagace, V. Lahiri, Z. Lai, Angela S Laird, Aparna Lakkaraju, T. Lamark, S. Lan, Ane Landajuela, D. Lane, J. Lane, C. Lang, C. Lange, Ü. Langel, R. Langer, P. Lapaquette, J. Laporte, N. F. LaRusso, I. Lastres-Becker, W. Lau, G. Laurie, S. Lavandero, B. Law, H. K. Law, R. Layfield, W. Le, H. Le Stunff, Alexandre Y Leary, J. Lebrun, Lionel Y W Leck, J. Leduc-Gaudet, Choonseok Lee, C. Lee, Da-Hye Lee, E. Lee, E. F. Lee, G. Lee, He-Jin Lee, H. K. Lee, J. Lee, J. Lee, Jina Lee, J. Lee, J. H. Lee, Michael Lee, M. H. Lee, M. H. Lee, M. Lee, Sang Rim Lee, Seungjae Lee, Stella Lee, S. B. Lee, W. H. Lee, Ying-Ray Lee, Y. Lee, Youngil Lee, C. Lefebvre, R. Legouis, Y. Lei, Yuchen Lei, S. Leikin, G. Leitinger, Leticia Lemus, S. Leng, Olivia Lenoir, G. Lenz, H. Lenz, P. Lenzi, Y. León, A. M. Leopoldino, Christoph Leschczyk, Stina Leskelä, E. Letellier, Chi-ting Leung, P. Leung, J. Leventhal, B. Levine, P. Lewis, K. Ley, B. Li, Da‐Qiang Li, J. Li, J. Li, J. Li, K. Li, L. Li, Mei Li, M. Li, M. Li, M. Li, P. Li, Mingqing Li, Qing Li, Sheng Li, Tiangang Li, W. Li, Wenming Li, X. Li, Y. Li, Y. Li, Zhiqiang Li, Zhi-yong Li, Z. Li, J. Lian, C. Liang, Q. Liang, W. Liang, Yongheng Liang, YongTian Liang, Guanghong Liao, L. Liao, Mingzhi Liao, Yung-Feng Liao, Mariangela Librizzi, Pearl P Y Lie, M. Lilly, H. J. Lim, T. R. R. Lima, Federica Limana, Chao Lin, Chih-Wen Lin, Dar-Shong Lin, F. Lin, J. Lin, K. M. Lin, K. Lin, Liang-Tzung Lin, P. Lin, Q. Lin, Shaofeng Lin, Su-Ju Lin, W. Lin, Xueying Lin, Yao-Xin Lin, Yee-Shin Lin, R. Linden, Paula Lindner, S. Ling, P. Lingor, A. Linnemann, Yih-Cherng Liou, M. Lipinski, S. Lipovšek, V. Lira, N. Lisiak, P. Liton, Chao Liu, Ching-Hsuan Liu, C. Liu, C. H. Liu, F. Liu, Hao Liu, H. Liu, H. Liu, H. Liu, J. Liu, J. Liu, J. Liu, L. Liu, L. Liu, M. Liu, Q. Liu, W. Liu, W. Liu, Xiao-Hong Liu, Xiaodong Liu, Xingguo Liu, X. Liu, Xuedong Liu, Y. Liu, Y. Liu, Y. Liu, Yueyang Liu, Y. Liu, J. A. Livingston, G. Lizard, J. Lizcano, Senka Ljubojevic-Holzer, M. LLeonart, David Llobet-Navàs, A. Llorente, Chih Hung Lo, Damián Lobato-Márquez, Q. Long, Y. Long, B. Loos, Julia Loos, M. G. López, Guillermo López-Doménech, J. López-Guerrero, A. T. López-Jiménez, Óscar López-Pérez, I. López-Valero, M. Lorenowicz, M. Lorente, P. Lőrincz, L. Lossi, S. Lotersztajn, P. Lovat, J. Lovell, Alenka Lovy, P. Lőw, Guang Lu, H. Lu, Jia-Hong Lu, Jinjian Lu, M. Lu, Shuyan Lu, A. Luciani, J. Lucocq, P. Ludovico, M. Luftig, M. Luhr, D. Luis-Ravelo, J. Lum, Liany Luna-Dulcey, A. H. Lund, Viktor K. Lund, J. Lünemann, Patrick Lüningschrör, H. Luo, Rongcan Luo, Shou-Qing Luo, Z. Luo, Claudio Luparello, B. Lüscher, Luan Luu, A. Lyakhovich, K. Lyamzaev, A. H. Lystad, L. Lytvynchuk, A. Ma, Changle Ma, Mengxiao Ma, Ning-Fang Ma, Quan-Hong Ma, X. Ma, Yue-yun Ma, Z. Ma, O. A. MacDougald, F. Macian, G. MacIntosh, J. MacKeigan, K. Macleod, S. Maday, F. Madeo, M. Madesh, T. Madl, J. Madrigal-Matute, A. Maeda, Y. Maejima, M. Magariños, P. Mahavadi, Emiliano Maiani, K. Maiese, P. Maiti, M. Maiuri, B. Majello, M. Major, E. Makareeva, Fayaz Malik, Karthik Mallilankaraman, W. Malorni, A. Maloyan, N. Mammadova, Gene Chi-Wai Man, F. Manai, J. Mancias, E. Mandelkow, Michael A Mandell, A. Manfredi, M. Manjili, Ravi Manjithaya, P. Manque, B. Manshian, Raquel Manzano, Claudia Manzoni, Kai Mao, C. Marchese, S. Marchetti, A. M. Marconi, F. Marcucci, S. Mardente, O. Mareninova, M. Margeta, Muriel Mari, S. Marinelli, O. Marinelli, G. Mariño, S. Mariotto, R. S. Marshall, M. Marten, S. Martens, A. P. Martin, Katie R. Martin, S. Martín, S. Martin, Adrián Martín-Segura, M. A. Martín-Acebes, I. Martín-Burriel, M. Martin-Rincon, P. Martı́n-Sanz, J. Martina, W. Martinet, A. Martínez, A. Martínez, J. Martinez, Moisés Martínez Velázquez, N. Martinez-Lopez, M. Martínez-Vicente, D. O. Martins, J. Martins, W. K. Martins, Tânia Martins-Marques, E. Marzetti, Shashank Masaldan, C. Masclaux-Daubresse, D. Mashek, Valentina Massa, L. Massieu, G. R. Masson, L. Masuelli, A. Masyuk, Tetyana V. Masyuk, P. Matarrese, A. Matheu, Satoaki Matoba, S. Matsuzaki, Pamela Mattar, A. Matte', D. Mattoscio, J. L. Mauriz, M. Mauthe, Caroline Mauvezin, E. Maverakis, P. Maycotte, J. Mayer, G. Mazzoccoli, C. Mazzoni, Joseph R Mazzulli, N. McCarty, C. McDonald, M. McGill, S. McKenna, B. McLaughlin, F. McLoughlin, M. McNiven, Thomas G. McWilliams, Fatima Mechta-Grigoriou, T. Medeiros, D. L. Medina, L. Megeney, K. Megyeri, Maryam Mehrpour, J. Mehta, A. Meijer, A. Meijer, Jakob Mejlvang, A. Meléndez, Annette Melk, Gonen Memisoglu, A. F. Mendes, Delong Meng, Fei Meng, Tian Meng, R. Menna-Barreto, M. Menon, C. Mercer, A. E. Mercier, Jean-Louis Mergny, A. Merighi, Seth D. Merkley, G. Merla, V. Meske, Ana Cecilia Mestre, Shree Padma Metur, C. Meyer, H. Meyer, Wenyi Mi, J. Mialet-Perez, J. Miao, L. Micale, Y. Miki, Enrico Milan, M. Milczarek, D. L. Miller, S. Miller, S. Miller, S. Millward, I. Milosevic, E. Minina, H. Mirzaei, H. Mirzaei, Mehdi Mirzaei, A. Mishra, Nandita Mishra, P. K. Mishra, Maja Misirkic Marjanovic, R. Misasi, A. Misra, G. Misso, C. Mitchell, G. Mitou, T. Miura, S. Miyamoto, M. Miyazaki, M. Miyazaki, T. Miyazaki, Keisuke Miyazawa, N. Mizushima, T. Mogensen, B. Mograbi, R. Mohammadinejad, Y. Mohamud, Abhishek Mohanty, Sipra Mohapatra, T. Möhlmann, A. Mohmmed, A. Moles, K. Moley, M. Molinari, V. Mollace, A. B. Møller, B. Mollereau, F. Mollinedo, C. Montagna, M. J. Monteiro, A. Montella, L. Montes, B. Montico, V. K. Mony, G. Monzio Compagnoni, M. N. Moore, M. Moosavi, A. Mora, M. Mora, D. Morales-Alamo, R. Moratalla, P. Moreira, Elena Morelli, S. Moreno, Daniel Moreno-Blas, V. Moresi, B. Morga, A. H. Morgan, F. Morin, H. Morishita, O. Moritz, M. Moriyama, Y. Moriyasu, M. Morleo, E. Morselli, Jose F Moruno-Manchon, J. Moscat, S. Mostowy, E. Motori, A. F. Moura, N. Moustaid-Moussa, Maria Mrakovcic, Gabriel Muciño-Hernández, A. Mukherjee, S. Mukhopadhyay, Jean M. Mulcahy Levy, V. Mulero, S. Muller, Christian Münch, A. Munjal, P. Muñoz-Cánoves, Teresa Muñoz-Galdeano, C. Münz, T. Murakawa, Claudia Muratori, B. Murphy, J. Murphy, A. Murthy, T. Myöhänen, Indira U. Mysorekar, J. Mytych, S. Nabavi, M. Nabissi, Péter Nagy, Jihoon Nah, A. Nahimana, I. Nakagawa, K. Nakamura, H. Nakatogawa, S. Nandi, M. Nanjundan, M. Nanni, G. Napolitano, R. Nardacci, M. Narita, Melissa Nassif, I. Nathan, M. Natsumeda, R. Naudé, Christin Naumann, O. Naveiras, Fatemeh Navid, S. Nawrocki, T. Y. Nazarko, Francesca Nazio, F. Negoita, T. Neill, Amanda L Neisch, L. Neri, M. Netea, Patrick Neubert, T. Neufeld, D. Neumann, A. Neutzner, P. T. Newton, P. Ney, I. Nezis, C. C. W. Ng, T. Ng, H. T. T. Nguyen, L. T. Nguyen, H. Ni, C. Ní Cheallaigh, Z. Ni, M. C. Nicolao, Francesco Nicoli, M. Nieto-Díaz, P. Nilsson, S. Ning, Rituraj Niranjan, H. Nishimune, M. Niso-Santano, R. Nixon, A. Nobili, Clévio Nóbrega, T. Noda, U. Nogueira-Recalde, Trevor M. Nolan, Iván Nombela, I. Novak, B. Novoa, Takashi Nozawa, N. Nukina, Carmen Nussbaum-Krammer, J. Nylandsted, T. O’Donovan, Seónadh M. O’Leary, Eyleen J. O’Rourke, M. O'Sullivan, Timothy E. O’Sullivan, Salvatore Oddo, I. Oehme, M. Ogawa, E. Ogier-Denis, M. H. Ogmundsdottir, B. Ogretmen, G. T. Oh, Seon-Hee Oh, Young J. Oh, T. Ohama, Y. Ohashi, M. Ohmuraya, V. Oikonomou, R. Ojha, K. Okamoto, H. Okazawa, M. Oku, S. Olivan, J. Oliveira, M. Ollmann, J. A. Olzmann, Shakib Omari, M. Omary, Gizem Önal, Martin Ondrej, Sang-Bing Ong, S. Ong, A. Onnis, J. Orellana, Sara Orellana-Muñoz, M. Ortega-Villaizan, X. Ortiz-Gonzalez, E. Ortona, H. Osiewacz, A. Osman, R. Osta, M. Otegui, K. Otsu, Christiane Ott, L. Ottobrini, J. J. Ou, Tiago F. Outeiro, Inger Oynebraten, M. Ozturk, G. Pagès, Susanta Pahari, M. Pajares, U. Pajvani, Rituraj Pal, S. Paladino, N. Pallet, Michela Palmieri, G. Palmisano, C. Palumbo, F. Pampaloni, L. Pan, Qingjun Pan, Wenliang Pan, Xin Pan, G. Panasyuk, R. Pandey, U. Pandey, V. Pandya, Francesco Paneni, S. Pang, E. Panzarini, D. Papademetrio, Elena Papaleo, Daniel Papinski, Diana Papp, E. C. Park, H. Park, Ji-man Park, Jong-In Park, J. Park, J. Park, S. C. Park, S. Park, A. Parola, J. Parys, Adrien Pasquier, B. Pasquier, J. Passos, N. Pastore, H. Patel, D. Patschan, S. Pattingre, G. Pedraza-Alva, J. Pedraza-Chaverri, Z. Pedrozo, Gang Pei, Jianming Pei, Hadas Peled-Zehavi, J. M. Pellegrini, Joffrey Pelletier, M. A. Peñalva, Di Peng, Ying Peng, F. Penna, M. Pennuto, Francesca Pentimalli, C. M. Pereira, G. Pereira, L. C. Pereira, L. Pereira de Almeida, N. D. Perera, Á. Pérez-Lara, Ana B. Perez-Oliva, M. E. Pérez-Pérez, P. Periyasamy, A. Perl, C. Perrotta, I. Perrotta, R. Pestell, Morten Petersen, I. Petrache, G. Petrovski, Thorsten Pfirrmann, Astrid S. Pfister, J. Philips, Huifeng Pi, A. Picca, Alicia M. Pickrell, S. Picot, G. Pierantoni, M. Pierdominici, P. Pierre, V. Pierrefite-Carle, Karolina Pierzynowska, F. Pietrocola, M. Pietruczuk, C. Pignata, F. X. Pimentel-Muiños, M. Pinar, R. O. Pinheiro, R. Pinkas-Kramarski, P. Pinton, Karolina Pircs, S. Piya, P. Pizzo, T. Plantinga, Harald W. Platta, Ainhoa Plaza-Zabala, M. Plomann, E. Plotnikov, H. Plun-Favreau, R. Pluta, R. Pocock, S. Pöggeler, Christian Pohl, M. Poirot, A. Poletti, Marisa Ponpuak, H. Popelka, B. Popova, H. Porta, S. Porte Alcon, E. Portilla-Fernandez, M. Post, Malia B. Potts, J. Poulton, T. Powers, Veena Prahlad, Tomasz K. Prajsnar, Domenico Praticò, R. Prencipe, M. Priault, Tassula Proikas-Cezanne, V. Promponas, C. Proud, R. Puertollano, L. Puglielli, Thomas Pulinilkunnil, Deepika Puri, Rajat Puri, J. Puyal, Xiaopeng Qi, Yongmei Qi, W. Qian, L. Qiang, Y. Qiu, J. Quadrilatero, J. Quarleri, N. Raben, H. Rabinowich, Debora Ragona, M. Ragusa, N. Rahimi, M. Rahmati, V. Raia, Nuno Raimundo, Namakkal-Soorappan Rajasekaran, S. Ramachandra Rao, A. Rami, Ignacio Ramírez-Pardo, D. B. Ramsden, F. Randow, P. Rangarajan, D. Ranieri, H. Rao, Lang Rao, R. Rao, S. Rathore, J. Ratnayaka, E. Ratovitski, Palaniyandi Ravanan, G. Ravegnini, S. Ray, B. Razani, V. Rebecca, F. Reggiori, Anne Régnier-Vigouroux, A. Reichert, David Reigada, J. H. Reiling, T. Rein, S. Reipert, R. Rekha, Hongmei Ren, Jun Ren, Weichao Ren, T. Renault, G. Renga, K. Reue, K. Rewitz, Bruna Ribeiro de Andrade Ramos, S. Riazuddin, Teresa M. Ribeiro-Rodrigues, Jean-Ehrland Ricci, R. Ricci, V. Riccio, D. R. Richardson, Y. Rikihisa, M. Risbud, R. Risueño, K. Ritis, S. Rizza, R. Rizzuto, H. Roberts, Luke D Roberts, Katherine Robinson, Maria Carmela Roccheri, S. Rocchi, G. Rodney, Tiago Rodrigues, Vagner Ramon Rodrigues Silva, A. Rodríguez, R. Rodríguez-Barrueco, N. Rodríguez-Henche, H. Rodríguez-Rocha, J. Roelofs, Robert S. Rogers, V. Rogov, A. Rojo, K. Rolka, V. Romanello, L. Romani, A. Romano, P. Romano, David Romeo-Guitart, L. C. Romero, M. Romero, Joseph C. Roney, Christopher Rongo, S. Roperto, M. Rosenfeldt, P. Rosenstiel, A. Rosenwald, K. Roth, L. Roth, S. Roth, K. Rouschop, B. Roussel, S. Roux, P. Rovere-Querini, A. Roy, A. Rozieres, D. Ruano, D. Rubinsztein, M. Rubtsova, K. Ruckdeschel, C. Ruckenstuhl, E. Rudolf, R. Rudolf, A. Ruggieri, Avnika A Ruparelia, P. Rusmini, R. R. Russell, G. Russo, M. Russo, R. Russo, O. Ryabaya, K. Ryan, K. Ryu, María Sabater-Arcis, Ulka Sachdev, M. Sacher, C. Sachse, Abhishek Sadhu, Jun-ichi Sadoshima, N. Safren, P. Saftig, Antonia P. Sagona, G. Sahay, Amirhossein Sahebkar, M. Sahin, O. Sahin, S. Sahni, Nayuta Saito, S. Saito, Tsunenori Saito, Ryohei Sakai, Y. Sakai, Jun-ichi Sakamaki, K. Saksela, G. Salazar, Anna Salazar-Degracia, G. H. Salekdeh, A. Saluja, B. Sampaio-Marques, María Cecilia M’Causland Sánchez, J. A. Sánchez-Alcázar, Victoria Sanchez-Vera, V. Sancho-Shimizu, J. Sanderson, M. Sandri, S. Santaguida, L. Santambrogio, M. Santana, G. Santoni, Alberto Sanz, P. Sanz, S. Saran, Marco Sardiello, Timothy J. Sargeant, A. Sarin, C. Sarkar, S. Sarkar, M. Sarrias, S. Sarkar, Dipanka Tanu Sarmah, J. Sarparanta, Aishwarya Sathyanarayan, Ranganayaki Sathyanarayanan, K. M. Scaglione, Francesca Scatozza, L. Schaefer, Z. Schafer, U. Schaible, A. Schapira, M. Scharl, Hermann M Schatzl, C. Schein, W. Scheper, David Scheuring, M. V. Schiaffino, M. Schiappacassi, R. Schindl, U. Schlattner, O. Schmidt, R. Schmitt, S. Schmidt, I. Schmitz, E. Schmukler, A. Schneider, Bianca Schneider, Romana Schober, Alejandra C. Schoijet, M. Schott, Michael Schramm, B. Schröder, K. Schuh, Christoph Schüller, Ryan J Schulze, Lea Schürmanns, J. Schwamborn, M. Schwarten, Filippo Scialo, S. Sciarretta, M. Scott, K. Scotto, A. Scovassi, A. Scrima, A. Scrivo, David Sebastián, Salwa Sebti, S. Sedej, Laura Segatori, N. Segev, P. Seglen, I. Seiliez, E. Seki, S. Selleck, F. Sellke, J. T. Selsby, M. Sendtner, Serif Senturk, Elena Seranova, C. Sergi, Ruth Serra-Moreno, H. Sesaki, C. Settembre, S. R. Setty, Gianluca Sgarbi, O. Sha, J. Shacka, J. A. Shah, Dantong Shang, Changshun Shao, F. Shao, S. Sharbati, Lisa M. Sharkey, D. Sharma, Gaurav Sharma, K. Sharma, Pawan Sharma, S. Sharma, Han-Ming Shen, H. Shen, Jiangang Shen, M. Shen, Weili Shen, Zheni Shen, R. Sheng, Zhi Sheng, Z. Sheng, J. Shi, Xiaobing Shi, Y. Shi, Kahori Shiba-Fukushima, Jeng-Jer Shieh, Y. Shimada, S. Shimizu, Makoto Shimozawa, T. Shintani, Christopher J Shoemaker, S. Shojaei, I. Shoji, Bhupendra V. Shravage, V. Shridhar, C. Shu, H. Shu, Ke Shui, A. Shukla, T. Shutt, Valentina Sica, A. Siddiqui, A. Sierra, Virginia Sierra-Torre, S. Signorelli, Payel Sil, B. J. Silva, J. Silva, E. Silva-Pavez, S. Silvente-Poirot, R. Simmonds, A. Simon, H. Simon, M. Simons, Anurag Singh, L. Singh, R. Singh, S. Singh, S. Singh, Sudha B. Singh, S. Singh, S. Singh, D. Sinha, R. Sinha, S. Sinha, A. Sirko, Kapil Sirohi, E. Sivridis, P. Skendros, A. Skirycz, I. Slaninová, S. Smaili, A. Smertenko, M. Smith, S. Soenen, E. J. Sohn, Sophia P M Sok, G. Solaini, T. Soldati, S. Soleimanpour, R. M. Soler, A. Solovchenko, J. Somarelli, Avinash Sonawane, Fuyong Song, H. Song, Ju-Xian Song, Kunhua Song, Z. Song, L. Soria, M. Sorice, A. Soukas, Sandra-Fausia Soukup, Diana Sousa, N. Sousa, P. A. Spagnuolo, S. Spector, M. M. Srinivas Bharath, D. St Clair, V. Stagni, Leopoldo Staiano, Clint A Stalnecker, M. Stankov, P. Stathopulos, Katja Stefan, Sven Marcel Stefan, L. Stefanis, J. Steffan, A. Steinkasserer, H. Stenmark, J. Sterneckert, C. Stevens, V. Stoka, S. Storch, B. Stork, F. Strappazzon, A. Strohecker, D. Stupack, Huanxing Su, Ling-Yan Su, L. Su, A. M. Suarez-Fontes, C. Subauste, Selvakumar Subbian, Paula V Subirada, G. Sudhandiran, C. Sue, Xinbing Sui, C. Summers, Guangchao Sun, Jun Sun, Kang Sun, M. Sun, Q. Sun, Y. Sun, Z. Sun, Karen K. S. Sunahara, E. Sundberg, K. Suszták, P. Sutovsky, H. Suzuki, G. Sweeney, J. D. Symons, S. C. W. Sze, N. Szewczyk, A. Tabęcka-Łonczyńska, Claudio Tabolacci, F. Tacke, H. Taegtmeyer, M. Tafani, M. Tagaya, Haoran Tai, S. Tait, Y. Takahashi, Szabolcs Takáts, P. Talwar, Chit Tam, S. Tam, Davide Tampellini, Astushi Tamura, Chong Teik Tan, E. Tan, Ya-Qin Tan, Masaki Tanaka, M. Tanaka, D. Tang, J. Tang, Tieshan Tang, I. Tanida, Zhipeng Tao, M. Taouis, Lars Tatenhorst, Nektarios Tavernarakis, A. Taylor, G. Taylor, J. Taylor, E. Tchetina, A. Tee, I. Tegeder, D. Teis, N. Teixeira, F. Teixeira‐Clerc, Kumsal Tekirdag, T. Tencomnao, S. Tenreiro, A. Tepikin, P. Testillano, Gianluca Tettamanti, Pierre-Louis Tharaux, K. Thedieck, Arvind A Thekkinghat, S. Thellung, Josephine W Thinwa, V. P. Thirumalaikumar, S. Thomas, P. Thomes, A. Thorburn, Lipi Thukral, T. Thum, M. Thumm, L. Tian, A. Tichý, A. Till, V. Timmerman, V. Titorenko, S. Todi, Krassimira Todorova, J. Toivonen, Luana Tomaipitinca, D. Tomar, C. Tomás‐Zapico, S. Tomić, B. Tong, C. Tong, Xin Tong, S. Tooze, M. Torgersen, Satoru Torii, Liliana Torres-López, A. Torriglia, Christina G. Towers, R. Towns, S. Toyokuni, V. Trajkovic, D. Tramontano, Quynh-Giao Tran, L. H. Travassos, Charles B Trelford, Shirley Tremel, I. Trougakos, B. Tsao, M. Tschan, H. Tse, Tak Fu Tse, H. Tsugawa, Andrey S Tsvetkov, David A Tumbarello, Yasin Tumtas, M. Tuñón, S. Turcotte, B. Turk, V. Turk, B. J. Turner, Richard I. Tuxworth, J. Tyler, E. Tyutereva, Y. Uchiyama, Aslihan Ugun-Klusek, H. Uhlig, Marzena Ułamek-Kozioł, I. Ulasov, M. Umekawa, C. Ungermann, Rei Unno, S. Urbé, E. Uribe-Carretero, S. Üstün, V. Uversky, T. Vaccari, M. Vaccaro, B. Vahsen, H. Vakifahmetoglu-Norberg, Rut Valdor, M. J. Valente, A. Valko, R. Vallee, A. Valverde, G. Van den Berghe, Stijn van der Veen, L. Van Kaer, J. van Loosdregt, Sjoerd J L van Wijk, W. Vandenberghe, I. Vanhorebeek, M. Vannier-Santos, Nicola Vannini, M. C. Vanrell, C. Vantaggiato, Gabriele Varano, I. Varela-Nieto, M. Varga, M. Vasconcelos, Somya Vats, D. Vavvas, I. Vega-Naredo, S. Vega-Rubin-de-Celis, G. Velasco, Ariadna P. Velázquez, T. Vellai, E. Vellenga, F. Velotti, M. Verdier, P. Verginis, I. Vergne, P. Verkade, M. Verma, P. Verstreken, T. Vervliet, J. Vervoorts, A. Vessoni, V. Víctor, M. Vidal, Chiara Vidoni, O. Vieira, R. Vierstra, Sonia Viganó, H. Vihinen, V. Vijayan, M. Vila, Marçal Vilar, José M. Villalba, A. Villalobo, B. Villarejo-Zori, F. Villarroya, J. Villarroya, O. Vincent, C. Vindis, C. Viret, M. Viscomi, D. Visnjic, I. Vitale, D. Vocadlo, O. Voitsekhovskaja, C. Volonté, M. Volta, M. Vomero, Clarissa von Haefen, M. Vooijs, W. Voos, Ljubica M Vucicevic, R. Wade-Martins, S. Waguri, Kenrick A Waite, S. Wakatsuki, D. W. Walker, Mark J. Walker, S. Walker, J. Walter, F. Wandosell, B. Wang, Chao-Yung Wang, Chen Wang, C. Wang, Chenwei Wang, C. Wang, D. Wang, Fangyang Wang, F. Wang, F. Wang, Guansong Wang, H. Wang, H. Wang, He-Xiang Wang, H. Wang, J. Wang, Jigang Wang, Jiou Wang, Jundong Wang, Kui Wang, Lianrong Wang, Liming Wang, M. H. Wang, M. Wang, Nanbu Wang, Pengwei Wang, Peipei Wang, P. Wang, P. Wang, Q. Wang, Qian Wang, Q. Wang, Q. A. Wang, W. Wang, Wuyang Wang, Xinnan Wang, X. Wang, Yan Wang, Yanchang Wang, Yanzhuang Wang, Yen-Yun Wang, Yihua Wang, Yipeng Wang, Yu Wang, Yuqi Wang, Zhenghao Wang, Zhen-yu Wang, Z. Wang, G. Warnes, Verena Warnsmann, H. Watada, Eizo Watanabe, Maxinne Watchon, Anna Wawrzyńska, T. E. Weaver, G. Węgrzyn, A. M. Wehman, Hua-feng Wei, Lei Wei, T. Wei, Yongjie Wei, O. Weiergräber, C. Weihl, G. Weindl, R. Weiskirchen, A. Wells, R. Wen, Xin Wen, A. Werner, Beatrice Weykopf, S. Wheatley, J. Whitton, A. Whitworth, Katarzyna Wiktorska, M. Wildenberg, T. Wileman, Simon Wilkinson, D. Willbold, Brett Williams, R. S. Williams, R. Williams, P. Williamson, R. A. Wilson, B. Winner, Nathaniel J Winsor, S. Witkin, H. Wodrich, Ute Woehlbier, Thomas Wollert, E. Wong, J. Wong, R. Wong, Vincent K W Wong, W. Wong, An-Guo Wu, C. Wu, J. Wu, J. Wu, K. Wu, M. Wu, S. Wu, Shengzhou or sheng-zhou wu, Shuyan Wu, Shufang Wu, W. Wu, X. Wu, Xiaoqing Wu, Yao-Wen Wu, Y. Wu, Ramnik J. Xavier, H. Xia, Li-xin Xia, Zhengyuan Xia, G. Xiang, Jin Xiang, M. Xiang, W. Xiang, Bin Xiao, G. Xiao, Hengyi Xiao, Hong-tao Xiao, J. Xiao, L. Xiao, S. Xiao, Yin Xiao, Baoming Xie, Chuan-Ming Xie, M. Xie, Yu-Xiang Xie, Z. Xie, Z. Xie, M. Xilouri, Congfeng Xu, E. Xu, Haoxing Xu, J. Xu, Jin-Rong Xu, L. Xu, W. Xu, X. Xu, Yu Xue, S. M. Yakhine-Diop, M. Yamaguchi, O. Yamaguchi, A. Yamamoto, S. Yamashina, S. Yan, Shian-Jang Yan, Z. Yan, Y. Yanagi, Chuanbin Yang, D. Yang, H. Yang, Huang-Tian Yang, H. Yang, J. Yang, J. Yang, J. Yang, L. Yang, L. Yang, M. Yang, Pei-Ming Yang, Qian Yang, Seungwon Yang, S. Yang, S. Yang, W. Yang, W. Yang, X. Yang, Xuesong Yang, Yi Yang, Ying Yang, H. Yao, S. Yao, X. Yao, Y. Yao, Yongming Yao, T. Yasui, M. Yazdankhah, P. Yen, Cong Yi, X. Yin, Y. Yin, Zhangyuan Yin, Ziyi Yin, M. Ying, Z. Ying, C. Yip, Stephanie Pei Tung Yiu, Y. H. Yoo, K. Yoshida, Saori R Yoshii, T. Yoshimori, B. Yousefi, Boxuan Yu, Haiyang Yu, J. Yu, J. Yu, L. Yu, Ming-Lung Yu, S. Yu, V. C. Yu, W. Yu, Z. Yu, Zhou Yu, J. Yuan, Ling-Qing Yuan, Shilin Yuan, Shyng-Shiou F. Yuan, Yanggang Yuan, Zengqiang Yuan, Jianbo Yue, Z. Yue, J. Yun, R. Yung, D. Zacks, Gabriele Zaffagnini, V. Zambelli, I. Zanella, Q. Zang, S. Zanivan, S. Zappavigna, P. Zaragoza, Konstantinos S. Zarbalis, Amir Zarebkohan, A. Zarrouk, S. Zeitlin, Jialiu Zeng, Ju-deng Zeng, E. Žerovnik, Lixuan Zhan, Bin Zhang, D. Zhang, Hanlin Zhang, H. Zhang, H. Zhang, H. Zhang, H. Zhang, H. Zhang, H. Zhang, H. Zhang, J. Zhang, J. Zhang, J. Zhang, K. Y. Zhang, L. Zhang, L. Zhang, L. Zhang, L. Zhang, Luoying Zhang, Menghuan Zhang, P. Zhang, S. Zhang, Wei Zhang, X. Zhang, X. Zhang, X. Zhang, X. Zhang, X. Zhang, X. Zhang, X. D. Zhang, Y. Zhang, Y. Zhang, Y. Zhang, Yingdong Zhang, Y. Zhang, Y. Zhang, Y. Zhang, Z. Zhang, Z. Zhang, Z. Zhang, Z. Zhang, Zhiyong Zhang, Z. Zhang, H. Zhao, Lei Zhao, Shuang Zhao, T. Zhao, X. Zhao, Y. Zhao, Y. Zhao, Yongliang Zhao, Y. Zhao, G. Zheng, K. Zheng, Ling Zheng, Shizhong Zheng, Xi-Long Zheng, Y. Zheng, Zuguo Zheng, B. Zhivotovsky, Q. Zhong, A. Zhou, Ben Zhou, Cefan Zhou, G. Zhou, H. Zhou, Hong Zhou, Huixin Zhou, Jie Zhou, J. Zhou, J. Zhou, Jiyong Zhou, Kailiang Zhou, R. Zhou, X. Zhou, Yanshuang Zhou, Y. Zhou, Y. Zhou, Zhengyu Zhou, Z. Zhou, Binglin Zhu, Changlian Zhu, Guoqing Zhu, H. Zhu, Hongxin Zhu, H. Zhu, Wei-Guo Zhu, Yanping Zhu, Yushan Zhu, Haixia Zhuang, Xiaohong Zhuang, Katarzyna Zientara-Rytter, C. Zimmermann, Elena Ziviani, T. Zoladek, Wei-Xing Zong, D. Zorov, A. Zorzano, W. Zou, Zhen Zou, Zhengzhi Zou, Steven Zuryn, W. Zwerschke, Beate Brand-Saberi, X. C. Dong, C. S. Kenchappa, Zuguo Li, Yong Lin, Shigeru Oshima, Yueguang Rong, J. Sluimer, C. L. Stallings, Chunmei Tong
Autophagy, 2021
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Comparison of tenocyte populations from the core and periphery of equine tendons
Cheng Zhang, Rene B. Svensson, Costanza Montagna, Helena Carstensen, Rikke Buhl, Erwin M. Schoof, Michael Kjaer, S. Peter Magnusson, Ching-Yan Chloé Yeung
Journal of Proteome Research, 2020
Tendon is a highly organized, dense connective tissue that has been demonstrated to have very little turnover. In spite of the low turnover, tendon can grow in response to loading, which may take place primarily at the periphery. Tendon injuries and recurrence of injuries are common in both human and animal in sports. It is unclear why some areas of the tendon are more susceptible to such injury and whether this is due to intrinsic regional differences in extracellular matrix (ECM) production or tissue turnover. This study aimed to compare populations of tenocytes derived from the tendon core and periphery. Tenocytes were isolated from equine superficial digital flexor tendons (SDFT), and the proliferation capacity was determined. ECM production was characterized by immuno- and histological staining and by liquid chromatography-mass spectrometry-based proteomics. Core and periphery SDFT cultures exhibited comparable proliferation rates and had very similar proteome profiles, but showed biological variation in collagen type I deposition. In conclusion, the intrinsic properties of tenocytes from different regions of the tendon are very similar and other factors in the tissue may contribute to how specific areas respond to loading or injury.
When S-Nitrosylation gets to mitochondria: From signaling to age-related diseases
Costanza Montagna, Claudia Cirotti, Salvatore Rizza, Giuseppe Filomeni
Antioxidants and Redox Signaling, 2020
nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
Costanza Montagna, Salvatore Rizza, Claudia Cirotti, Emiliano Maiani, Maurizio Muscaritoli, Antonio Musarò, Maria Teresa Carrí, Elisabetta Ferraro, Francesco Cecconi, Giuseppe Filomeni
Cell Death and Disease, 2019
S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy
Salvatore Rizza, Simone Cardaci, Costanza Montagna, Giuseppina Di Giacomo, Daniela De Zio, Matteo Bordi, Emiliano Maiani, Silvia Campello, Antonella Borreca, Annibale A. Puca, Jonathan S. Stamler, Francesco Cecconi, Giuseppe Filomeni
Proceedings of the National Academy of Sciences of the United States of America, 2018
To eat, or NOt to eat: S-nitrosylation signaling in autophagy
Costanza Montagna, Salvatore Rizza, Emiliano Maiani, Lucia Piredda, Giuseppe Filomeni, Francesco Cecconi
FEBS Journal, 2016
Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+
Barbara Benassi, Giuseppe Filomeni, Costanza Montagna, Caterina Merla, Vanni Lopresto, Rosanna Pinto, Carmela Marino, Claudia Consales
Molecular Neurobiology, 2016
S-nitrosylation of the mitochondrial chaperone TRAP1 sensitizes hepatocellular carcinoma cells to inhibitors of succinate dehydrogenase
Salvatore Rizza, Costanza Montagna, Simone Cardaci, Emiliano Maiani, Giuseppina Di Giacomo, Virginia Sanchez-Quiles, Blagoy Blagoev, Andrea Rasola, Daniela De Zio, Jonathan S. Stamler, Francesco Cecconi, Giuseppe Filomeni
Cancer Research, 2016
S -Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis
Salvatore Rizza, Claudia Cirotti, Costanza Montagna, Simone Cardaci, Claudia Consales, Mauro Cozzolino, Maria Teresa Carrì, Francesco Cecconi, Giuseppe Filomeni
Mediators of Inflammation, 2015
S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction
Costanza Montagna, Giuseppina Di Giacomo, Salvatore Rizza, Simone Cardaci, Elisabetta Ferraro, Paolo Grumati, Daniela De Zio, Emiliano Maiani, Carolina Muscoli, Filomena Lauro, Sara Ilari, Sergio Bernardini, Stefano Cannata, Cesare Gargioli, Maria R. Ciriolo, Francesco Cecconi, Paolo Bonaldo, Giuseppe Filomeni
Antioxidants and Redox Signaling, 2014
S -nitrosation and ubiquitin-proteasome system interplay in neuromuscular disorders
Salvatore Rizza, Costanza Montagna, Giuseppina Di Giacomo, Claudia Cirotti, Giuseppe Filomeni
International Journal of Cell Biology, 2014
Reticulon1-C modulates protein disulphide isomerase function
P Bernardoni, B Fazi, A Costanzi, R Nardacci, C Montagna, G Filomeni, M R Ciriolo, M Piacentini, F Di Sano
Cell Death and Disease, 2013
Established principles and emerging concepts on the interplay between mitochondrial physiology and S -(De)nitrosylation: Implications in cancer and neurodegeneration
Giuseppina Di Giacomo, Salvatore Rizza, Costanza Montagna, Giuseppe Filomeni
International Journal of Cell Biology, 2012

COSTANZA MONTAGNA

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS