Protective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats Mehmet Hanifi Okur, Serkan Arslan, Bahattin Aydogdu, Hikmet Zeytun, Erol Basuguy, Mehmet Serif Arslan, Ibrahim Ibiloglu, Ibrahim Kaplan Journal of Investigative Surgery, 2018 Objective: To investigate the role of cordycepin in testicular ischemia/reperfusion injury in rats. Materials and methods: Forty Wistar albino rats were randomly divided into four groups, as follows: group one, control (C); group two, torsion and ischemia (I); group three: detorsion with ischemia–reperfusion (IR); and group four, detorsion/cordycepin. The rats were then analyzed macromorphologically and histopathologically, and blood tests were performed. Specifically, the total oxidant status (TOS) and total antioxidant status (TAS) were determined, and malondialdehyde (MDA), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β levels were analyzed. In addition, pyknotic nuclei, spermatozoa, edema, and hemorrhage were assessed. Results: When the IR and cordycepin groups were compared with the other groups, there was a statistically significant decrease in TNF-α and MDA levels (p < 0.05). Increased TAS levels were observed in the cordycepin group compared with the control group. TOS levels were significantly increased in the I and IR groups, but decreased in the cordycepin group (p < 0.05). Similar effects were observed in tissue biochemistry analysis. Histopathological evaluations revealed that the spermatozoa count was decreased in the I and IR groups. However, there was an increase in the cordycepin group, as well as a statistically significant difference between the IR and cordycepin groups (p < 0.01). Finally, edema and inflammation were increased in the I and IR groups, but decreased in the cordycepin group. Conclusions: Histological and biochemical findings revealed that cordycepin protected against IR-induced testicular injury.
Operative and non-operative management ofchildren with abdominal gunshot injuries Mehmet Serif Arslan Ulusal Travma Ve Acil Cerrahi Dergisi, 2018 BACKGROUND Non-operative management (NOM) is a standard treatment method for solid organ injuries worldwide. There is no consensus on the management of gunshot wounds (GSW) because of the higher frequency of hollow viscus injuries (HVI) and the unpredictable depth of tissue damage produced by kinetic energy transfer during retardation of the bullet. Here we aimed to reevaluate indications for surgery and NOM based on our pediatric patients with abdominal GSW. METHODS We performed a retrospective analysis of patients evaluated and treated for abdominal GSW at University of Dicle between January 2010 and October 2016. Patients with hemodynamic instability, signs of peritonitis on serial abdominal examination, and free air in the abdomen underwent laparotomy; these were included in group I (n=17). Patients managed non-operatively were included in group II (n=13). RESULTS Our statistical analysis showed significantly lower Hb levels and systolic blood pressure levels (p<0.001) and higher pulse rate, higher mean injury severity score, and longer length of stay at intensive care unit in patients in group I than in those in group II (p<0.001). We further detected colon perforation (n=10) and small bowel perforation (n=7) in patients in group I; liver laceration (n=4), splenic injury (n=1), and renal injury (n=3) but no solid organ injury or HVI (n=5) were detected in patients in group II. CONCLUSION The major drawback of NOM is the difficulty in diagnosing HVI in abdominal GSW, which may delay treatment. We suggest that patients with solid organ damage who are hemodynamically stable and exhibit no signs of peritonitis upon serial abdominal exam may be treated with NOM.
Management of high-grade renal injury in children M. H. Okur, S. Arslan, B. Aydogdu, M. S. Arslan, C. Goya, H. Zeytun, E. Basuguy, I. Uygun, M. K. Çigdem, A. Önen, S. Otcu European Journal of Trauma and Emergency Surgery, 2017
Oral ketamine administration for radiation therapy in children Biomedical Research India, 2017
Effects of Ecballium Elaterium on Proinflammatory Cytokines in a Rat Model of Sepsis Mehmet Serif Arslan, Erol Basuguy, Ibrahim Ibiloglu, Eda Bozdemir, Hikmet Zeytun, Atalay Sahin, Ibrahim Kaplan, Bahattin Aydogdu, Selcuk Otcu Journal of Investigative Surgery, 2016 Objective: Ecballium elaterium (EE) is a plant from Cucurbitaceae family. Its anti-inflammatory role in sepsis is not well understood. We investigated the effects of EE on serum levels of proinflammatory cytokines and further explored the mechanisms underlying histological changes in liver and ileum following EE administration in a polymicrobial sepsis model. Methods: Thirty rats were divided into three groups of 10 rats each. Rats were subjected to sham laparotomy plus normal saline administration (control group, CG), laparotomy with cecal ligation and puncture (CLP) (sepsis group, SG), and laparotomy with CLP plus 2.5 mg/kg EE administration (experimental group, EG). Twenty-four hours after laparotomy, animals underwent cardiac puncture, and blood was collected for interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) assessment. Whole sections of liver and ileum tissues were collected for histologic examination. Results: The serum level of IL-6 was significantly lower in EG as compared to SG. Although IL-6 levels were shown a statistically significant (p < 0.0001) decline to near control values, no significant changes were observed in serum levels of IL-1 and TNF-α after EE treatment. Histologic examination revealed statistically significant reduction in collagen formation (p = 0.001) on serosal surface of ileum and hepatic venous congestion (p = 0.040) in EG as compared to SG. Conclusion: EE might play a protective role in sepsis prevention and treatment by decreasing IL-6 production and reducing liver damage and may influence bacterial translocation by reinforcing intestinal barrier function.
A case of isolated female epispadias and our approach to treatment M.S. Arslan, S. Arslan, H. Zeytun, E. Basuguy, M. Ozkir, B. Aydogdu, M.H. Okur, I. Uygun African Journal of Urology, 2016 Cases of isolated female epispadias (IFE) without exstrophy of the bladder are quite rare. The clinical symptoms of IFE are abnormal external genitalia with primary urinary incontinence. Our patient was a 7-year-old girl with total urinary incontinence. Physical examination revealed a patulous urethra, bifid labia minora, and a bifid clitoris. The vagina and hymen appeared to be normal. Uroflowmetry demonstrated an overflow-type pathological voiding pattern with low voiding pressure. A voiding cystourethrogram showed no indications of reflux. To treat our IFE patient, we performed a single stage genital approach reconstruction of the urethra, clitoris, and labia minora. Follow up with the patient ensured that she was continent and that her external genitals took on an acceptable appearance.
The outcome of percutaneous nephrolithotomy using intravenous catheter for obtaining percutaneous access as a treatment for renal stone disease in children: A Pilot Study Urology Journal, 2016
Perforation of Meckel's diverticulum by foreign body Journal of the Pakistan Medical Association, 2014
Gastrointestinal tract duplications in children European Review for Medical and Pharmacological Sciences, 2014
Traumatic diaphragmatic rupture in children Mehmet Hanifi Okur, Ibrahim Uygun, Mehmet Serif Arslan, Bahattin Aydogdu, Ahmet Turkoglu, Cemil Goya, Mustafa Icen, Murat Kemal Cigdem, Abdurrahman Onen, Selcuk Otcu Journal of Pediatric Surgery, 2014
Penis replantation after self-mutilation Ahmet Ozturk, Mehmet Kilinc, Selcuk Guven, Niyazi Gormus, Metin Belviranli, Mehmet Kaynar, Mehmet Arslan International Urology and Nephrology, 2009
Endourological treatment of bladder leiomyoma Gazi Medical Journal, 2008
Protective effect of cordycepin on experimental testicular ischemia/reperfusion injury in rats MH Okur, S Arslan, B Aydogdu, H Zeytun, E Basuguy, MS Arslan, I Ibiloglu, ... Journal of Investigative Surgery 31 (1), 1-8 , 2018 2018 Citations: 32
Single-Port Laparoscopic Surgery Technique in Children Using Glove-Port and Conventional Rigid Instruments MS Arslan, S Arslan, H Zeytun, E Basuguy, B Aydogdu, MH Okur, ... Indian Journal of Surgery 80, 327-332 , 2018 2018 Citations: 1
Operative and non-operative management of children with abdominal gunshot injuries MŞ Arslan, H Zeytun, S Arslan, E Basuguy, M Okur, B Aydogdu, C Goya, ... ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY … , 2018 2018 Citations: 5
Çocuklarda Böbrek Taşlarında Retrograd İntrarenal Cerrahinin (RİRC) Erken Dönem Sonuçları: Ön Çalışma H ZEYTUN, S ARSLAN, MŞ ARSLAN, E BASUGUY, B AYDOĞDU, ... Firat Tip Dergisi 22 (3) , 2017 2017
Management of high-grade renal injury in children MH Okur, S Arslan, B Aydogdu, MS Arslan, C Goya, H Zeytun, E Basuguy, ... European Journal of Trauma and Emergency Surgery 43 (1), 99-104 , 2017 2017 Citations: 34
Adölesan varikosel tedavisinde laparoskopik Palomo yöntemi sonuçlarımız S Arslan, E Basuguy, H Zeytun, MS Arslan, B Aydogdu, S Bayram, ... Ortadoğu Tıp Dergisi 9 (2), 56-60 , 2017 2017
Oral ketamine administration for radiation therapy in children. MK Erdal Doğan, Abdulmenap Güzel, Seyit Burhanedtin Zincircioğlu, Mehmet ... Biomedical Research 28 (2), 755-759 , 2017 2017
Analysis of risk factors for appendicitis in children: a multicenter epidemiological study S Arslan, B Aydogdu, MS Arslan, H Zeytun, MH Okur, E Basuguy, ... Dicle Medical Journal 43 (4), 556-560 , 2016 2016 Citations: 13
The adrenal gland: an organ neglected in pediatric trauma cases B Aydogdu, MH Okur, S Arslan, MS Arslan, H Zeytun, E Basuguy, M Icer, ... Urology Journal 13 (6), 2916 , 2016 2016 Citations: 6
Management of gastrointestinal perforation from blunt and penetrating abdominal trauma in children: analysis of 96 patients S Arslan, MH Okur, MS Arslan, B Aydogdu, H Zeytun, E Basuguy, M Icer, ... Pediatric surgery international 32 (11), 1067-1073 , 2016 2016 Citations: 34
Effects of Ecballium Elaterium on Proinflammatory Cytokines in a Rat Model of Sepsis MS Arslan, E Basuguy, I Ibiloglu, E Bozdemir, H Zeytun, A Sahin, I Kaplan, ... Journal of Investigative Surgery 29 (6), 399-404 , 2016 2016 Citations: 17
A case of isolated female epispadias and our approach to treatment MS Arslan, S Arslan, H Zeytun, E Basuguy, M Ozkir, B Aydogdu, MH Okur, ... African Journal of Urology 22 (3), 193-195 , 2016 2016 Citations: 4
Predicting pseudocyst formation following pancreatic trauma in pediatric patients B Aydogdu, S Arslan, H Zeytun, MS Arslan, E Basuguy, M İçer, C Goya, ... Pediatric surgery international 32 (6), 559-563 , 2016 2016 Citations: 21
The outcome of percutaneous nephrolithotomy using intravenous catheter for obtaining percutaneous access as a treatment for renal stone disease in children: a pilot study MS Arslan, H Zeytun, E Basuguy, S Arslan, B Aydogdu, MH Okur Urology Journal 13 (1), 2502-2508 , 2016 2016 Citations: 8
Prokinetik Ajanlarýn Proksimal ve Distal Kolon Motilitesi Üzerine Etkileri/Effects of Prokinetic Agents on Motility of Proximal and Distal Colon MS Arslan, A Altun, C Güney, L Cankorkmaz, I Bagcivan, G Köylüoglu Dicle Tip Dergisi 43 (1), 151 , 2016 2016 Citations: 1
Congenital-infantile fibrosarcoma of the ileocecal region: the first case presentation H Zeytun, MH Okur, E Basuguy, S Arslan, B Aydogdu, G Turkcu, ... Pediatric surgery international 32 (1), 97-99 , 2016 2016 Citations: 12
A rare cause of ileus in an infant: a case of gossypiboma MS Arslan, S Arslan, I Uygun J Pak Med Assoc 65 (11), 1245-6 , 2015 2015 Citations: 1
Amyand’s hernia complicated with acute appendicitis: A case report and literature review MH Okur, MS Arslan, H Zeytun, S Otcu Ped Urol Case Rep 2 (4), 7-12 , 2015 2015 Citations: 16
Jejunoileal perforation and volvulus caused by multiple magnet ingestion S Arslan, E Basuguy, H Zeytun, M Hanifi Okur, B Aydogdu, M Serif Arslan Acta clinica Croatica 54 (1.), 96-98 , 2015 2015 Citations: 18
Case Report A Rare Cause of Intestinal Obstruction in Infants: Ileum Duplication Cyst and Literature Review MS Arslan, E Basuguy, H Zeytun, S Arslan, B Aydogdu, MH Okur, M Ozkir, ... 2015
MOST CITED SCHOLAR PUBLICATIONS
Amyand's hernia in the children: a single center experience L Cankorkmaz, H Ozer, C Guney, MH Atalar, MS Arslan, G Koyluoglu Surgery 147 (1), 140-143 , 2010 2010 Citations: 136
The perforation problem in hydatid disease. EM Sözüer, E Ok, M Arslan The American journal of tropical medicine and hygiene 66 (5), 575-577 , 2002 2002 Citations: 106
Gastrointestinal tract duplications in children MH Okur, MS Arslan, S Arslan, B Aydogdu, G Türkçü, C Goya, I Uygun, ... Eur Rev Med Pharmacol Sci 18 (10), 1507-1512 , 2014 2014 Citations: 58
Fluoroscopic balloon dilatation for caustic esophageal stricture in children: an 8-year experience I Uygun, MS Arslan, B Aydogdu, MH Okur, S Otcu Journal of pediatric surgery 48 (11), 2230-2234 , 2013 2013 Citations: 54
Traumatic diaphragmatic rupture in children MH Okur, I Uygun, MS Arslan, B Aydogdu, A Turkoglu, C Goya, M Icen, ... Journal of Pediatric Surgery 49 (3), 420-423 , 2014 2014 Citations: 44
Yatırım fonu performans ölçütleri, regresyon analizleri ve MANOVA yöntemine göre A, B ve borsa yatırım fonlarının karşılaştırmalı analizi M Arslan, S Arslan İşletme Araştırmaları Dergisi 2 (2), 3-20 , 2010 2010 Citations: 38
Management of high-grade renal injury in children MH Okur, S Arslan, B Aydogdu, MS Arslan, C Goya, H Zeytun, E Basuguy, ... European Journal of Trauma and Emergency Surgery 43 (1), 99-104 , 2017 2017 Citations: 34
Management of gastrointestinal perforation from blunt and penetrating abdominal trauma in children: analysis of 96 patients S Arslan, MH Okur, MS Arslan, B Aydogdu, H Zeytun, E Basuguy, M Icer, ... Pediatric surgery international 32 (11), 1067-1073 , 2016 2016 Citations: 34
Protective effect of cordycepin on experimental testicular ischemia/reperfusion injury in rats MH Okur, S Arslan, B Aydogdu, H Zeytun, E Basuguy, MS Arslan, I Ibiloglu, ... Journal of Investigative Surgery 31 (1), 1-8 , 2018 2018 Citations: 32
Portal vein thrombosis in cirrhotics: related with anticardiolipin antibodies? G Oksüzoglu, Y Bayraktar, S Arslan, I Celik, M Arslan, B Sivri, S Kirazli, ... Hepato-gastroenterology 50 (53), 1527-1530 , 2003 2003 Citations: 23
Predicting pseudocyst formation following pancreatic trauma in pediatric patients B Aydogdu, S Arslan, H Zeytun, MS Arslan, E Basuguy, M İçer, C Goya, ... Pediatric surgery international 32 (6), 559-563 , 2016 2016 Citations: 21
Intermuscular hydatid cyst in a 4-year-old child: a case report L Cankorkmaz, H Ozturk, G Koyluoglu, MH Atalar, MS Arslan Journal of pediatric surgery 42 (11), 1946-1948 , 2007 2007 Citations: 19
Jejunoileal perforation and volvulus caused by multiple magnet ingestion S Arslan, E Basuguy, H Zeytun, M Hanifi Okur, B Aydogdu, M Serif Arslan Acta clinica Croatica 54 (1.), 96-98 , 2015 2015 Citations: 18
Intra-peritoneal administration of Ecballium elaterium diminishes postoperative adhesions MH Okur, B Aydogdu, MS Arslan, U Alabalik, S Arslan, İ Kara, F Canpolat, ... Acta cirurgica brasileira 29 (10), 639-643 , 2014 2014 Citations: 18
Effects of Ecballium Elaterium on Proinflammatory Cytokines in a Rat Model of Sepsis MS Arslan, E Basuguy, I Ibiloglu, E Bozdemir, H Zeytun, A Sahin, I Kaplan, ... Journal of Investigative Surgery 29 (6), 399-404 , 2016 2016 Citations: 17
Amyand’s hernia complicated with acute appendicitis: A case report and literature review MH Okur, MS Arslan, H Zeytun, S Otcu Ped Urol Case Rep 2 (4), 7-12 , 2015 2015 Citations: 16
Transumbilical scarless surgery with thoracic trocar: easy and low-cost I Uygun, MH Okur, B Aydogdu, MS Arslan, H Cimen, S Otcu Journal of the Korean Surgical Society 84 (6), 360-366 , 2013 2013 Citations: 14
Analysis of risk factors for appendicitis in children: a multicenter epidemiological study S Arslan, B Aydogdu, MS Arslan, H Zeytun, MH Okur, E Basuguy, ... Dicle Medical Journal 43 (4), 556-560 , 2016 2016 Citations: 13
A rare anomaly of biliary system: MRCP evidence of a cystic duct cyst C Goya, MS Arslan, A Yavuz, C Hamidi, S Kuday, MH Okur, B Aydogdu Case Reports in Radiology 2014 (1), 291071 , 2014 2014 Citations: 13
Congenital-infantile fibrosarcoma of the ileocecal region: the first case presentation H Zeytun, MH Okur, E Basuguy, S Arslan, B Aydogdu, G Turkcu, ... Pediatric surgery international 32 (1), 97-99 , 2016 2016 Citations: 12
