finite elements
isogeometric analysis
additive manufacturing
computer simulations
cardiovascular mechanics
99
Scopus Publications
3453
Scholar Citations
35
Scholar h-index
63
Scholar i10-index
Scopus Publications
From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements Gabriele Greco, Pierfrancesco Gaziano, Serena Anglese, Simone Morganti, Carlo de Vincentiis, Ferdinando Auricchio, Michele Marino, Michele Conti Advanced Functional Materials, 2026 Bioprosthetic aortic valves, especially those implanted via transcatheter methods, have transformed the treatment of aortic stenosis. Nevertheless, their long‐term durability is still limited by structural valve deterioration. While clinical and hemodynamic factors have been extensively reviewed, the material science perspective on bioprosthetic valve deterioration has received comparatively less attention. Structural valve deterioration is, however, a complex, multiscale, and multifactorial process, in which mechanical fatigue and calcification of bovine or porcine pericardial tissue play central roles. For this reason, this review focuses on the pericardium itself—the engineered soft tissue at the core of bioprosthetic valves. The experimental techniques used to characterize its properties across multiple length scales, from molecular composition to macroscopic mechanics, are examined, highlighting how these multiscale measurements reveal critical structure–function relationships. Such insights are crucial for more accurate modeling of pericardial behavior and for understanding its deterioration in vivo. By integrating bioengineering, advanced physical characterization, and computational modeling, a framework is outlined that links material properties to valve‐level performance and, ultimately, clinical durability. This perspective not only advances the fundamental understanding of structural valve deterioration but also provides guidance for designing next‐generation bioprosthetic and synthetic polymeric valves with improved longevity.
Triply periodic minimal surfaces for gradient impedance matching layers in ultrasonic transducers D D’Aprile, F Auricchio, S Morganti Engineering Research Express, 2025 Ultrasonic transducers are widely used in various fields, including industrial non-destructive testing, underwater detection, and medical diagnostics. A key challenge in optimizing their performance is the impedance mismatch between the piezoelectric elements and the surrounding medium, which significantly affects energy transmission efficiency. Traditional matching layers, such as quarter-wavelength ( λ /4) structures, enhance transmission around a specific frequency but suffer from narrow bandwidth limitations. To address this issue, broadband matching layers with gradually varying acoustic impedance have been proposed. In this study, we introduce a new broadband matching layer design based on Triply Periodic Minimal Surfaces (TPMS), specifically utilizing primitive unit cells with a quasi-exponential density variation along the wave propagation direction. These structures can be easily designed with a continuously varying material distribution and efficiently fabricated using additive manufacturing techniques. We develop finite element models of the proposed designs, which demonstrate high efficiency in terms of energy transmission, showing a clear improvement in the transmission coefficient compared to conventional solutions. Additionally, our acoustic numerical results indicate that the number of unit cells significantly influences the presence of frequency band gaps. This characteristic could be leveraged to design matching layers that selectively block specific frequency ranges.
Patient-specific computational fluid hemodynamics in the ascending aorta before and after thoracic endovascular repair Alessandro Ruggeri, Marco Magliocco, Bianca Pane, Marco Canepa, Sara Seitun, Giovanni Pratesi, Costantino Menna, Simone Morganti, Giovanni Spinella, Michele Conti Computers in Biology and Medicine, 2025 OBJECTIVE: To study hemodynamic variations due to thoracic endovascular aortic repair (TEVAR) by computational fluid dynamics (CFD). DESIGN & METHODS: Five patients were prospectively included in the study. For each patient, we collected cardio-computed tomography angiography scans, electrocardiogram measurements, and additional clinical data, including heart rate, systolic and diastolic blood pressures, and blood volumes, both before and after surgery. Such information was used to create patient-specific digital twin models. We conducted CFD simulations by integrating both geometric and clinical parameters of digital twins. Our analysis focused on bulk flow, velocity streamlines, flow distribution, and areas exposed to atherogenic stimuli. We calculated the time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT) to assess the conditions before and after TEVAR. Additionally, we measured the geometric parameters of the ascending aorta (length, diameter, and tortuosity) both before and after TEVAR. RESULTS: Mean age of the patients was 71 years; average time between follow-up appointments was 448 days. Three patients were women and two were men. Small geometric changes appear to occur in the aortic root and ascending aorta following stent insertion. Areas with low TAWSS tend to decrease overall, with a mean reduction of 23.55 % (±22.40); a more pronounced decrease of 29.16 % (±26.51) was observed in the endograft implantation area. The variation trends in areas with high OSI show a considerable level of interpatient variability, but generally tend to increase within the endograft, with an average increase of 5.23 % (±4.30). There is an average reduction of 32.62 % (±15.97) in the mean RRT value for each patient after TEVAR. Systolic flow patterns do not vary significantly. Coronary perfusion levels remain within the ranges reported in the literature. Coronary flow increases in three out of five patients. CONCLUSION: No significant geometric remodeling is observed after TEVAR treatments; however, pronounced hemodynamic changes occur, leading to a reduced atherogenic risk. Nonetheless, there is considerable variability among patients.
Engineering Approach to Study the Effect of TEVAR on the Cardiovascular System: A Systematic Review Marco Magliocco, Michele Conti, Bianca Pane, Giovanni Pratesi, Marco Canepa, Sara Seitun, Simone Morganti, Antonio Salsano, Giovanni Spinella Annals of Vascular Surgery, 2025 BACKGROUND: To study the effect of endovascular treatment of the thoracic aorta on cardiac geometry and evaluate the effects of stent placement on hemodynamics and cardiovascular biomechanics. METHODS: Articles were selected through the use of online databases such as PubMed, Scopus, and Web of Science, investigating the use of engineering methods (computational analysis and simulations using three-dimensional models of cardiovascular structures obtained from medical imaging) to study the effects of pretreatment and posttreatment Thoracic Endovascular Aortic Repair (TEVAR) in terms of left ventricular mass variation and assessment of fluid dynamics parameters such as Wall Shear Stress (WSS), flow variations, and velocity. The quality of the included studies was assessed using the Newcastle-Ottawa scale. RESULTS: A total of 11 studies were considered: 3 reported data on left ventricular mass variation, 5 reported flow and velocity variations, and 6 provided information on WSS. A high discrepancy in results and methodology for conducting the analyses was observed. Overall, an increase in left ventricular mass was observed in patients undergoing TEVAR, while an improvement in flow conditions and stress was noted following the exclusion of the pathological aortic zone. CONCLUSIONS: To summarize, TEVAR can result in changes in vascular structures. However, the current literature on this topic is limited and the analysis methods used vary in terms of methodology, treated pathology, and follow-up duration. To successfully integrate computational simulations and engineering evaluations of medical images into clinical practice, it is crucial to standardize the analysis methods.
Investigation of microscale brittle fracture opening in diamond with olivine inclusion using XFEM and cohesive zone modeling Biswabhanu Puhan, Alessia Patton, Simone Morganti, Greta Rustioni, Alessandro Reali, Matteo Alvaro Engineering Fracture Mechanics, 2025 • XFEM/CZM models for brittle fractures in olivine-diamond systems. • Inclusion shape affects initial damage but has less impact on fracture propagation. • Brittle fracture plays a smaller role in stress relaxation than elastic effects. • Residual pressure suggests an interplay of inelastic deformation, fluids, and flaws. • Fracture mechanics provide interdisciplinary insights on diamond-inclusion systems. Inclusions trapped in diamonds are a fundamental source of information to probe the Earth’s interior, provided that the pressure conditions at which the diamond grew are correctly determined. This study explores the traditional assumptions in geothermobarometry for olivine-in-diamond host-inclusion systems by employing extended finite element methods (XFEM) and cohesive zone models (CZM) to quantify the contributions of brittle fractures to the relaxation of the residual stress of inclusions. Our analysis was performed assuming that the host-inclusion system does not contain fluids and that the unfractured minerals are elastically isotropic. Our models show that the damage initiation is solely dependent on the shape of the inclusion and on the fracture strength of the diamond host, while the fracture nucleation is influenced by both the size of the inclusion and the toughness of the diamond. Our findings indicate that, in dry systems, the amount of relaxation of residual stress of the inclusion due to the opening of brittle fractures is much lower than that due to the elastic interaction between the host and the inclusion. Moreover, the pressure release due to fractures is not substantially affected by the shape of the inclusion. We also show that the total relaxation of the residual pressure due to the combined effect of the elastic interaction and of the brittle deformation is lower than what is observed in natural samples, even when assuming fracture strength and toughness lower than those reported from experiments on single crystals of diamond. Such discrepancies suggest that in natural olivine-diamond systems additional mechanisms such as viscous or plastic deformation and/or the presence of preexisting defects and fluids in the host might play a relevant role in the relaxation of the residual stress. These findings underscore the need for advanced numerical tools that consider the complex interplay of the geometry of the host-inclusion system, the fracture properties, and the presence of fluids and defects in order to build more accurate models to constrain the geological history of diamonds.
Assessment of Vibration Frequencies of Piezo-Actuated Panel by Model-Assisted Self-Mixing Interferometry E. Bodo, L. Ciccarelli, V. Bello, S. Morganti, S. Merlo IEEE Open Journal of Instrumentation and Measurement, 2025 Flat surfaces driven by attached piezoelectric actuators are promising devices for the development of future generations of speakers. Although audio devices characterization requires sound pressure level measurements, preliminary testing of electromechanical frequency response and actuation efficiency may provide meaningful insights into the operation capability of these innovative systems. In this work, we have investigated a Plexiglas panel attached to a piezo-ceramic actuator as test structure. In particular, we successfully combined finite element analysis and out-of-plane displacement measurements performed with a semiconductor laser feedback (or self-mixing) interferometer in a few selected spots of the optically diffusing panel. To rapidly detect the spectral response, the actuator was driven by electrical white noise to obtain a photodetected interferometric signal in the frequency domain directly proportional to the vibration amplitude. Sinusoidal driving of the actuator at selected frequencies and interferometric signal analyses in the time domain allowed quantifying the actuation efficiency, as a function of the frequency and of the position on the panel, of the three mechanical modes exhibiting out-of-plane displacement in the range up to approximately 1 kHz. The values of natural frequencies numerically obtained match the experimentally detected values, with a difference up to 3%, 6%, and 9% for Mode 1, Mode 4, and Mode 8, respectively, that are the three lowest modes with effective modal mass along the z-direction.
Buckling of Planar Beams with Variable Inertia Donato D’Aprile, Simone Morganti, Arsenio Cutolo, Massimiliano Fraldi, Ferdinando Auricchio Advances and Challenges in Computational Mechanics, 2025
Coupling direct powder deposition with spark plasma sintering: a new approach towards rapid prototyping L. Airoldi, R. Brucculeri, P. Baldini, S. Morganti, M. Actis Grande, F. S. Gobber, F. Auricchio, U. Anselmi-Tamburini Progress in Additive Manufacturing, 2024 In this paper, we propose a modified material jetting technology based on a piezoelectric-driven powder deposition, hence direct powder deposition (DPD), combined with pressure-assisted rapid sintering. This is a new approach toward the rapid production of metal and ceramic materials with complex geometries. The combined deposition of two loose powders within the same container, layer by layer, allows realizing complex shapes without the use of any binder or dispersing medium. The resulting green sample is then sintered by field assisted sintering (FAST) or spark plasma sintering (SPS) operating in a pseudo-isostatic mode. This combination of DPD and FAST/SPS allows great versatility, as it can be extended to a wide range of materials and composites without any significant modification of the setup. Moreover, the use of FAST/SPS densification allows the realization of fully sintered samples in less than one hour.
Depth of diamond formation obtained from single periclase inclusions Chiara Anzolini, Fabrizio Nestola, Mattia L. Mazzucchelli, Matteo Alvaro, Paolo Nimis, Andrea Gianese, Simone Morganti, Federica Marone, Marcello Campione, Mark T. Hutchison, Jeffrey W. Harris Geology, 2019
Novel understanding on thoracic aortic diseases from bioengineering concepts T. M. J. van Bakel, F. J. H. Nauta, Michele Conti, Rodrigo Romarowski, Simone Morganti, J. A. van Herwaarden, C. Alberto Figueroa, F. Auricchio, Santi Trimarchi Surgical Management of Aortic Pathology Current Fundamentals for the Clinical Management of Aortic Disease, 2019
Aortic endovascular surgery Michele Conti, Simone Morganti, Alice Finotello, Rodrigo M. Romarowski, Alessandro Reali, Ferdinando Auricchio Sema Simai Springer Series, 2018
Natural stone masonry characterization for the shaking-table test of a scaled building specimen Proceedings of the International Masonry Society Conferences, 2018
Additive manufacturing for a low-cost biaxial testing machine Aimeta 2017 Proceedings of the 23rd Conference of the Italian Association of Theoretical and Applied Mechanics, 2017
Shape memory alloy: From constitutive modeling to finite element analysis of stent deployment CMES Computer Modeling in Engineering and Sciences, 2010
A discussion on SMA beams under flexure exploiting the shape-memory effect Computational Plasticity X Fundamentals and Applications, 2009
RECENT SCHOLAR PUBLICATIONS
Buckling of Planar Beams with Variable Inertia D D’Aprile, S Morganti, A Cutolo, M Fraldi, F Auricchio Advances and Challenges in Computational Mechanics, 17-32 , 2026 2026
From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements G Greco, P Gaziano, S Anglese, S Morganti, C de Vincentiis, F Auricchio, ... Advanced Functional Materials, e29555 , 2026 2026
Triply periodic minimal surfaces for gradient impedance matching layers in ultrasonic transducers D D’Aprile, F Auricchio, S Morganti Engineering Research Express 7 (4), 045544 , 2025 2025 Citations: 1
Patient-specific computational fluid hemodynamics in the ascending aorta before and after thoracic endovascular repair A Ruggeri, M Magliocco, B Pane, M Canepa, S Seitun, G Pratesi, ... Computers in Biology and Medicine 194, 110493 , 2025 2025 Citations: 3
Modelling, simulation, design and testing for additive manufacturing M Carraturo, S Kollmannsberger, A McBride, S Morganti Progress in Additive Manufacturing 10 (7), 4105-4106 , 2025 2025
Assessment of Vibration Frequencies of Piezo-actuated Panel by Model-Assisted Self-Mixing Interferometry E Bodo, L Ciccarelli, V Bello, S Morganti, S Merlo IEEE Open Journal of Instrumentation and Measurement , 2025 2025 Citations: 3
MULTI–STEPS MEDICAL AND ENGINEERING INTERACTION TO OPTIMIZE PREOPERATIVE PLANNING IN COMPLEX CARDIAC SURGICAL PROCEDURES P Totaro, S Marconi, S Morganti, M Musto, S Pelenghi, F Auricchio European Heart Journal Supplements 27 (Supplement_5), suaf076. 151 , 2025 2025
Engineering Approach to Study the Effect of TEVAR on the Cardiovascular System: A Systematic Review M Magliocco, M Conti, B Pane, G Pratesi, M Canepa, S Seitun, S Morganti, ... Annals of vascular surgery 114, 183-191 , 2025 2025
Investigation of microscale brittle fracture opening in diamond with olivine inclusion using advanced computational modelling B Puhan, M Alvaro, A Patton, A Reali, S Morganti EGU25 , 2025 2025 Citations: 1
Investigation of microscale brittle fracture opening in diamond with olivine inclusion using XFEM and cohesive zone modeling B Puhan, A Patton, S Morganti, G Rustioni, A Reali, M Alvaro Engineering Fracture Mechanics 314, 110713 , 2025 2025 Citations: 5
Coupling direct powder deposition with spark plasma sintering: a new approach towards rapid prototyping L Airoldi, R Brucculeri, P Baldini, S Morganti, MA Grande, FS Gobber, ... Progress in Additive Manufacturing 9 (6), 1953-1966 , 2024 2024 Citations: 3
Bicuspid Valve Aortopathy: Is It Reasonable to Define a Different Surgical Cutoff Based on Different Aortic Wall Mechanical Properties Compared to Those of the Tricuspid Valve? P Totaro, A Caimi, G Formenton, M Musto, M Schembri, S Morganti, ... Journal of Cardiovascular Development and Disease 11 (10), 312 , 2024 2024 Citations: 1
Assessment of the Aorto-Septal Angle Post-Thoracic Endovascular Aortic Repair through Segmentation and the Semi-Automatic Analysis of Cardiosynchronized Computed Tomography … M Magliocco, M Conti, B Pane, M Canepa, S Seitun, S Morganti, G Pratesi, ... Journal of Cardiovascular Development and Disease 11 (9), 275 , 2024 2024 Citations: 1
An efficient active-stress electromechanical isogeometric shell model for muscular thin film simulations M Torre, S Morganti, A Nitti, MD De Tullio, J Kiendl, FS Pasqualini, A Reali Mechanics of Materials 195, 105046 , 2024 2024 Citations: 3
Topologically optimized graded foams P Iaccarino, E Maresca, S Morganti, F Auricchio, E Di Maio Advanced Engineering Materials 26 (11), 2301798 , 2024 2024 Citations: 8
Spark plasma sintering of complex metal and ceramic structures produced by material extrusion R Brucculeri, L Airoldi, P Baldini, B Vigani, S Rossi, S Morganti, ... 3D printing and additive manufacturing 11 (3), 1246-1256 , 2024 2024 Citations: 6
SEM2: Introducing mechanics in cell and tissue modeling using coarse-grained homogeneous particle dynamics S Chattaraj, M Torre, C Kalcher, A Stukowski, S Morganti, A Reali, ... APL bioengineering 7 (4) , 2023 2023 Citations: 2
Current progress toward isogeometric modeling of the heart biophysics M Torre, S Morganti, FS Pasqualini, A Reali Biophysics Reviews 4 (4) , 2023 2023 Citations: 4
Aortic wall thickness in dilated ascending aorta: Comparison between tricuspid and bicuspid aortic valve P Totaro, S Morganti, F Auricchio, S Pelenghi Archives of Cardiovascular Diseases 116 (11), 498-505 , 2023 2023 Citations: 2
SEM 2 : A computational framework to model multiscale mechanics with subcellular elements S Chattaraj, M Torre, C Kalcher, A Stukowski, S Morganti, A Reali, ... bioRxiv, 2023.07. 07.548118 , 2023 2023 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Finite element analysis of additive manufacturing based on fused deposition modeling: Distortions prediction and comparison with experimental data A Cattenone, S Morganti, G Alaimo, F Auricchio Journal of Manufacturing Science and Engineering 141 (1), 011010 , 2019 2019 Citations: 221
Patient-specific isogeometric structural analysis of aortic valve closure S Morganti, F Auricchio, DJ Benson, FI Gambarin, S Hartmann, ... Computer methods in applied mechanics and engineering 284, 508-520 , 2015 2015 Citations: 195
Simulation of transcatheter aortic valve implantation through patient-specific finite element analysis: two clinical cases S Morganti, M Conti, M Aiello, A Valentini, A Mazzola, A Reali, F Auricchio Journal of biomechanics 47 (11), 2547-2555 , 2014 2014 Citations: 177
A framework for designing patient‐specific bioprosthetic heart valves using immersogeometric fluid–structure interaction analysis F Xu, S Morganti, R Zakerzadeh, D Kamensky, F Auricchio, A Reali, ... International journal for numerical methods in biomedical engineering 34 (4 … , 2018 2018 Citations: 158
Simulation of transcatheter aortic valve implantation: a patient-specific finite element approach F Auricchio, M Conti, S Morganti, A Reali Computer methods in biomechanics and biomedical engineering 17 (12), 1347-1357 , 2014 2014 Citations: 158
Statistical finite element analysis of the buckling behavior of honeycomb structures D Asprone, F Auricchio, C Menna, S Morganti, A Prota, A Reali Composite Structures 105, 240-255 , 2013 2013 Citations: 138
Prediction of patient-specific post-operative outcomes of TAVI procedure: The impact of the positioning strategy on valve performance S Morganti, N Brambilla, AS Petronio, A Reali, F Bedogni, F Auricchio Journal of biomechanics 49 (12), 2513-2519 , 2016 2016 Citations: 130
Human dilated ascending aorta: mechanical characterization via uniaxial tensile tests A Ferrara, S Morganti, P Totaro, A Mazzola, F Auricchio Journal of the mechanical behavior of biomedical materials 53, 257-271 , 2016 2016 Citations: 126
Elastic geothermobarometry: Corrections for the geometry of the host-inclusion system ML Mazzucchelli, P Burnley, RJ Angel, S Morganti, MC Domeneghetti, ... Geology 46 (3), 231-234 , 2018 2018 Citations: 123
Patient‐specific CFD modelling in the thoracic aorta with PC‐MRI–based boundary conditions: a least‐square three‐element Windkessel approach RM Romarowski, A Lefieux, S Morganti, A Veneziani, F Auricchio International journal for numerical methods in biomedical engineering 34 (11 … , 2018 2018 Citations: 107
Finite element analysis of TAVI: impact of native aortic root computational modeling strategies on simulation outcomes A Finotello, S Morganti, F Auricchio Medical Engineering & Physics 47 (1), 2-12 , 2017 2017 Citations: 97
A novel layered topology of auxetic materials based on the tetrachiral honeycomb microstructure F Auricchio, A Bacigalupo, L Gambarotta, M Lepidi, S Morganti, F Vadala Materials & Design 179, 107883 , 2019 2019 Citations: 88
Patient‐specific finite element analysis of carotid artery stenting: a focus on vessel modeling F Auricchio, M Conti, A Ferrara, S Morganti, A Reali International Journal for Numerical Methods in Biomedical Engineering 29 (6 … , 2013 2013 Citations: 65
Patient-specific simulation of a stentless aortic valve implant: the impact of fibres on leaflet performance F Auricchio, M Conti, A Ferrara, S Morganti, A Reali Computer methods in biomechanics and biomedical engineering 17 (3), 277-285 , 2014 2014 Citations: 62
Elastic geobarometry for anisotropic inclusions in cubic hosts ML Mazzucchelli, A Reali, S Morganti, RJ Angel, M Alvaro Lithos 350, 105218 , 2019 2019 Citations: 61
Shape memory alloy: from constitutive modeling to finite element analysis of stent deployment F Auricchio, M Conti, S Morganti, A Reali Computer Modeling in Engineering & Sciences 57 (3), 225 , 2010 2010 Citations: 59
Depth of diamond formation obtained from single periclase inclusions C Anzolini, F Nestola, ML Mazzucchelli, M Alvaro, P Nimis, A Gianese, ... Geology 47 (3), 219-222 , 2019 2019 Citations: 58
Vortex induced vibrations at high Reynolds numbers on circular cylinders M Belloli, S Giappino, S Morganti, S Muggiasca, A Zasso Ocean Engineering 94, 140-154 , 2015 2015 Citations: 57
Non-prismatic Timoshenko-like beam model: Numerical solution via isogeometric collocation G Balduzzi, S Morganti, F Auricchio, A Reali Computers & Mathematics with Applications 74 (7), 1531-1541 , 2017 2017 Citations: 54
Finite element analysis of transcatheter aortic valve implantation: Insights on the modelling of self-expandable devices A Finotello, R Gorla, N Brambilla, F Bedogni, F Auricchio, S Morganti Journal of the Mechanical Behavior of Biomedical Materials 123, 104772 , 2021 2021 Citations: 51