Since my education and training at the Medical School of the University of Milan, Italy, I focused my efforts in the area of pediatric diabetology and endocrinology. Until 2008 my training has been based in clinical settings, in particular in the treatment of children and adolescents with type 1 diabetes mellitus and endocrine diseases.
EDUCATION
2001: B.S Liceo Scientifico V.Veneto, Milan, Italy
2007: MD - Medicine University of Milan, Italy M.D.
2013: Residency in Pediatrics, University of Milan, Italy
204-2017/2018- ongoing Research Fellow in Pediatrics University of Milan/Luigi Sacco Hospital
Clinical and biochemical evaluation of children with short stature in the primary care setting: a systematic review Chiara Mameli, Rino Agostiniani, Giuseppe Banderali, Elena Bozzola, Vita Antonella Di Stefano, Luigi Greco, Carmine Pecoraro, Simone Rugolotto, Sara Sollai, Elvira Verduci, Liliana Guadagni, Claudio Lo Giudice, Gaetano Caforio, Annamaria Staiano Italian Journal of Pediatrics, 2026 Short stature is a frequent reason for pediatric referral, yet clear diagnostic criteria remain elusive. Variability in clinical definitions, reference growth charts, and laboratory screening tests complicates the evaluation of affected children. This systematic review aimed to analyze the diagnostic approaches used in clinical and biochemical assessments of short stature in children in the primary care setting. This systematic review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251002215). Two independent literature searches were performed to address two domains: clinical and biochemical assessment. Studies were selected based on predefined inclusion and exclusion criteria, and risk of bias was assessed using the JBI critical appraisal tools. All procedures were conducted by independent reviewers, and discrepancies were resolved by consensus or through a third reviewer. A total of 424 studies were included, 35 in the clinical and 7 in the biochemical domain. Definitions of short stature considered in the studies varied considerably: 28 studies used a threshold of < 2 standard deviation score, while 19 applied percentile-based cut-offs (mostly the 3rd percentile); 8 studies considered both definitions, 3 studies do not report any definition. Growth velocity and target height were rarely used, despite their diagnostic value. Local growth charts were employed when available; otherwise, WHO and CDC references were most used. Laboratory assessments also varied greatly, with complete blood count and urine/stool analyses commonly performed, while thyroid function and celiac disease screening were inconsistently applied. There is substantial heterogeneity in the clinical and biochemical evaluation of children with short stature across studies. This reflects the absence of universally accepted diagnostic criteria and standardized screening protocols. These findings emphasize the need for internationally accepted, evidence-based guidelines to improve diagnostic accuracy and clinical management of children with short stature.
Towards a shared diagnostic approach for pediatric short stature: a Delphi consensus of the Italian Society of Pediatrics and the Italian Society for Pediatric Endocrinology and Diabetology Chiara Mameli, Stefano Cianfarani, Luisa De Sanctis, Mohamad Maghnie, Malgorzata Wasniewska, Francesco Chiarelli, Maria Felicia Faienza, Maria Elisabeth Street, Giampaolo De Luca, Cinzia Sacchetti, Massimiliano Orso, Barbara Polistena, Rino Agostiniani, Valentino Cherubini, Annamaria Staiano, Mariacarolina Salerno Italian Journal of Pediatrics, 2026 Short stature is a common reason for referral in pediatric practice, but significant variability exists in diagnostic approaches and referral criteria. Therefore, the aim of this consensus was to improve the management of children with short stature through the knowledge and expertise of various Italian centers through a Delphi-consensus process. A multidisciplinary scientific board of 11 experts and 1 patient advocate were involved in a consensus process and used the Delphi method. The scientific board identified 4 key domains regarding short stature: clinical evaluation, biochemical assessment, imaging and genetic investigation. Two literature searches were conducted. The first search aimed to identify international guidelines and consensus on the diagnosis of short stature in children. The second search sought to retrieve clinical studies focusing on the four domains. The results of the literature searches were evaluated by the scientific board and a total of 14 statements were drafted and submitted to a panel of 39 pediatricians and pediatric endocrinologists using a two-round Delphi method conducted between February and March 2025. Consensus was defined as ≥ 80% agreement or disagreement (scores 7–9 or scores 1–3 on a 9-point Likert scale). In the first Delphi round, 34 out of 39 experts responded (response rate 87%), and consensus was reached on 11 out of 14 statements. The remaining 3 statements were revised by the scientific board and re-submitted. In the second round, 34 of 34 eligible experts responded (100%), and consensus was achieved for one additional statement. Overall, a strong agreement was reached for 12 out of 14 statements. This consensus provides valuable insights and recommendations to guide pediatricians in approaching a child with short stature. By addressing clinical, biochemical, imaging and genetic domains this consensus provides a model of growth monitoring that may result in early detection and appropriate management of children with short stature.
Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -Part II: management Silvia Salvatore, Caterina Strisciuglio, Elena Bozzola, Stefania Cappa, Antonio Corsello, Giovanni Di Nardo, Maurizio Fuoti, Liliana Guadagni, Antonino Gulino, Chiara Mameli, Massimiliano Orso, Licia Pensabene, Renato Tambucci, Francesca Vassallo, Claudio Romano, Annamaria Staiano, The Italian Society of Pediatrics (SIP), of The Italian Society of Pediatric Gastroenterology Hepatology, Nutrition (SIGENP) Italian Journal of Pediatrics, 2026 Suspected gastroesophageal reflux disease (GERD) is one of the most common reasons for referral to pediatric and gastroenterology clinics, and proton pump inhibitors (PPIs) are frequently prescribed. Currently, there is still wide heterogeneity in treatment, especially in neonates and extraesophageal presentations. This article aimed to provide guidelines and a consensus of Italian experts on the management of GERD in infants, children, and adolescents, in order to improve the care and treatment of these patients. A multidisciplinary pediatric panel identified four key clinical questions (PICOs) regarding pharmacological and non-pharmacological treatments, surgical intervention, and prognosis of pediatric GERD. Four databases (PubMed/Medline, Embase, Web of Science, and Google Scholar) were searched from inception to May 2024, using a specific search string for each PICO and limiting the search to children (0–18 years) and to English language. Previous pediatric guidelines, systematic reviews, and clinical trials focused on the treatment of GERD were considered to formulate evidence-based recommendations. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) and AGREE II systems were used to assess study quality; a 9-point Likert scale was used to rate the recommendations. A two-round Delphi method was conducted to reach consensus, defined as ≥ 80% agreement or disagreement. The systematic review identified three previous pediatric guidelines, eight systematic reviews, 83 RCTs, and three observational studies. The panel provided 26 recommendations regarding the management and treatment of GERD in pediatric patients. All reached consensus, with the majority expressing strong support for the intervention. The panel also provided practice insights for each PICO to improve the clinical application and clarity of these guidelines. Regurgitation is common in infants, but in most cases, no treatment is necessary. When regurgitation causes discomfort, a brief trial of alginate or thickened formulas or a cow’s milk elimination diet may be considered, particularly if other symptoms, including crying and dermatitis, are associated. For children who complain of heartburn or have severe neurologic deficits, a short course of empirical PPIs treatment may be considered, monitoring the clinical response and testing if no improvement is seen. PPIs are recommended in infants and children with reflux esophagitis, or acid reflux detected by esophageal pH monitoring. Children at high- risk for chronic GERD requiring prolonged treatment and multidisciplinary care have been identified. Surgery should be considered for severe or complicated GERD after a comprehensive diagnostic workup and optimal pharmacological management.
Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -part I. diagnosis Silvia Salvatore, Caterina Strisciuglio, Elena Bozzola, Stefania Cappa, Antonio Corsello, Giovanni Di Nardo, Maurizio Fuoti, Antonino Gulino, Chiara Mameli, Massimiliano Orso, Licia Pensabene, Barbara Polistena, Renato Tambucci, Francesca Vassallo, Claudio Romano, Annamaria Staiano, on behalf of The Italian Society of Pediatrics (SIP), of The Italian Society of Pediatric Gastroenterology Hepatology, Nutrition (SIGENP) Italian Journal of Pediatrics, 2026 Abstract Background Gastroesophageal reflux disease (GERD) is a common reason for referral to pediatric and gastroenterology clinics. Still, uncertainty and variability exist in the evaluation, diagnostic approaches and management among different age groups and clinicians. This study aimed to report the results of a Guidelines process and an Italian expert Consensus focusing on the diagnosis of GERD in children to improve the clinical approach to these patients. Methods A multidisciplinary board of 16 participants identified eight PICO (Population/Patient/Problem, Intervention, Comparator and Outcome) questions, including definition, signs and symptoms, risk factors, diagnostic tests, treatment and prognosis of gastroesophageal reflux (GER) and GERD in children: four PICO questions were related to the diagnosis of GERD. Four databases (PubMed/Medline, Embase, Web of Science and Google Scholar) were searched from their inception to May 11, 2024, limited to children (0–18 years) and English language. For each PICO question a specific search string was developed. Guidelines, systematic reviews and clinical studies on diagnosis and management in children were considered to formulate evidence-based recommendations. Agreement was defined based on a 9-point Likert scale. A two-round Delphi method was conducted and consensus was defined as ≥ 80% agreement or disagreement. This paper focused on clinical symptoms and diagnosis of GER and GERD in pediatric ages. Results 123 studies were included that satisfied systematic research criteria. The panel provided 14 recommendations on diagnosis of GER and GERD and practice points for specific questions to clarify some clinical issues. Conclusion Symptoms of GER(D) are common in the pediatric population while regurgitation is frequently reported in the first months of life. In infancy symptoms mostly disappear spontaneously or after dietary modification. In infants and children with esophageal or extresophageal persistent symptoms, esophageal pH-MII monitoring and endoscopy are indicated to detect and characterize reflux episodes, phenotypes of GERD and esophagitis. In older children and adolescents reporting typical heartburn or in those with severe neurological impairment, a time-limited empirical trial of PPI can be considered as an initial diagnostic approach, with further testing reserved for non-responders.
Reduced Diabetes Burden Over Glycemic Gains With the Dexcom G7 Upgrade in Youth on Automated Insulin Delivery System Andrea E. Scaramuzza, Ivana Rabbone, Roberto Franceschi, Elisa Giani, Marta Bassi, Maria Giulia Berioli, Riccardo Bonfanti, Claudio Cavalli, Francesca Di Candia, Dario Iafusco, Fortunato Lombardo, Donatella Lo Presti, Maddalena Macedoni, Giulio Maltoni, Chiara Mameli, Marco Marigliano, Nicola Minuto, Enza Mozzillo, Stefano Passanisi, Barbara Piccini, Elvira Piccinno, Barbara Predieri, Andrea Rigamonti, Carlo Ripoli, Silvia Savastio, Riccardo Schiaffini, Davide Tinti, Sonia Toni, Angela Zanfardino, Valentino Cherubini Diabetes Obesity and Metabolism, 2026
Long-term efficacy and safety of Control-IQ technology in younger children with type 1 diabetes in Italy (2020–2023): a longitudinal multicentre real-world study Valentino Cherubini, Roberto Franceschi, Andrea Fargalli, Marta Bassi, Riccardo Bonfanti, Giulia Bracciolini, Barbara Felappi, Riccardo Foglino, Dario Iafusco, Anna Lasagni, Bruno Bombaci, Claudio Maffeis, Giulio Maltoni, Chiara Mameli, Enza Mozzillo, Nicola Minuto, Barbara Piccini, Lara Devilli, Giulia Pezzino, Carmelo Pistone, Elena Prandi, Ivana Rabbone, Andrea Scaramuzza, Sara Santarelli, Francesca Silvestri, Riccardo Schiaffini, Valentina Tiberi, Davide Tinti, Marco Marigliano, Rosaria Gesuita, Donatella Lo Presti, Elvira Piccinno, Francesca Franco, Valeria De Donno, Petra Reinstadler, Silvia Sordelli, Vanna Graziani, Rosalia Roppolo, Anna Giulia Lambertini, Barbara Predieri, Emioli Randazzo, Elisabetta Delduca, Benedetta Vestrucci, Marilea Lezzi, Maurizio Delvecchio, Antonio Iannilli Eclinicalmedicine, 2026 Background: Automated insulin delivery (AID) systems have demonstrated significant improvements in glycemic control in children and adults with type 1 diabetes, but long-term real-world data in preschool-aged children remain limited, particularly in Europe, where Control-IQ is not approved for children under 6 years. This study aimed to evaluate the long-term effectiveness and safety of the t:slim X2 insulin pump with Control-IQ technology in children aged 0.5-5 years compared with those aged 6-10 years in a real-world multicenter Italian cohort. Methods: In this longitudinal, observational study conducted from 2020 to 2023, data were collected from 32 Italian centers on children <11 years diagnosed with type 1 diabetes for at least six months and using the t:slim X2 with Control-IQ technology (CIQ). Participants were grouped into 0.5-5 years or 6-10 years at CIQ initiation. Primary endpoints were the percentage of time spent in range (TIR, 70-180 mg/dL) and in tight range (TITR, 70-140 mg/dL) in the two age groups, evaluated according to children's demographic, socioeconomic, and clinical characteristics using mixed-effects models for repeated measures. Findings: We evaluated 253 children with 18-month follow-up, 131 into the 0.5-5-year group and 122 in the 6-10-year group. In the 0.5-5-year group, TIR and TITR increased significantly from baseline to 6 months and were then maintained through 18 months. In the 6-10-year group, similar improvements were observed, with no statistically significant differences between age groups in the TIR or TITR trajectories. In the adjusted mixed-effects models, TIR increased from baseline to 6 months by 5.45% (95% CI 3.78-7.11) and TITR increased by 5.56% (95% CI 3.60-7.51), with stabilization thereafter. Children of parents with a high level of education had a significantly greater mean TIR. A longer interval between T1D diagnosis and CIQ initiation was associated with a lower mean TITR (-1.21%, 95% CI -2.32 to -0.10). During observation, there were no episodes of severe hypoglycemia in younger children and only one episode in a 6-10-year-old. One episode of DKA occurred after the start of CIQ in a younger child. Interpretation: CIQ was associated with sustained improvements in glycemic outcomes, especially within the first six months. Adverse events were rare. These findings support potential supervised off-label use in young children. Funding: No specific funds were received for this study.
Secretory Acid Sphingomyelinase in Children and Adolescents With Type 1 Diabetes Chiara Mameli, Alice Bolchini, Cristina Ferrigno, Paulina Roux Biejat, Alessandro Arcari, Silvia Zecchini, Alessandra Napoli, Francesca Chiara Redaelli, Maddalena Macedoni, Agnese Petitti, Gianvincenzo Zuccotti, Emilio Clementi, Cristiana Perrotta Journal of Diabetes Research, 2026 Introduction The activity of acid sphingomyelinase (ASMase), a key enzyme in sphingolipid metabolism, has been found to be increased in a variety of human diseases. Studies conducted on animal and cellular models showed that sphingolipids and ASMase play a central role in the pathogenesis of type 1 diabetes (T1D) and T1D‐related vascular damage. Currently, no studies have investigated the role of ASMase activity in pediatric patients with T1D. Therefore, we conducted a cross‐sectional study to evaluate the activity of the secretory form of ASMase (S‐ASMase) in the serum of patients with T1D aged 2–16 years in comparison with a control group (healthy subjects matched for age, gender, and pubertal stage). Materials and Methods We recruited children and adolescents affected by T1D (including patients with new‐onset and established T1D) aged 2–16 years and healthy normal‐weight subjects with normal timing of puberty (matched for age, gender, and pubertal stage), who were consecutively admitted—as outpatients—to our institution for screening purposes. Serum lipid profile, glycated hemoglobin (HbA1c), and urine albumin–creatinine ratio (uACR) were assessed in all T1D patients. S‐ASMase activity was measured in all study participants through a colorimetric assay. Results In total, 68 T1D patients and 51 healthy controls were recruited in this study. None of the T1D patients had T1D‐related complications. No difference in S‐ASMase activity was observed between subjects with T1D and healthy controls. However, when T1D patients were stratified according to the duration of diabetes, we found a significantly higher activity of S‐ASMase in patients with new‐onset T1D (recruited within 1 week after the disease diagnosis) as compared to that observed in patients with established T1D. In all patients with T1D, S‐ASMase activity correlated positively with HbA1c and triglyceride levels, while it correlated negatively with total cholesterol (TC) and high‐density lipoprotein cholesterol (HDL‐C) levels. However, there were no significant differences in S‐ASMase activity between T1D patients with new‐onset disease who presented with diabetic ketoacidosis (DKA; n = 12) and T1D patients with new‐onset disease who did not present with DKA ( n = 13). Conclusion Our study evaluated, for the first time, the in vivo activity of S‐ASMase in a pediatric cohort of patients with T1D. In pediatric patients with new‐onset T1D, we found a significantly higher S‐ASMase activity as compared to that observed in patients with established T1D. In all T1D patients, the positive correlation between S‐ASMase activity, HbA1c, and triglyceride levels, as well as the negative correlation between S‐ASMase activity and HDL‐C levels, suggests a potential role played by sphingolipids in T1D pathophysiology. Further mechanistic studies are needed to better elucidate the role of S‐ASMase in patients with T1D at different stages of the disease.
Screening practices for diabetic peripheral neuropathy in pediatric type 1 diabetes: a nationwide survey by the ISPED Diabetes Study Group Bruno Bombaci, Marta Bassi, Valeria Castorani, Francesca Di Candia, Marta Ferrari, Mariangela Martino, Luca Zagaroli, Marco Marigliano, Riccardo Bonfanti, Diabetes Study Group of the Italian Society of Pediatric Endocrinology, Diabetology, Claudia Accursia Albino, Monica Aloe, Maria Teresa Anzelotti, Claudia Arnaldi, Fabrizio Barbetti, Marta Bassi, Maria Giulia Berioli, Luca Bernardini, Enrica Bertelli, Martina Biagioni, Adriana Bobbio, Bruno Bombaci, Riccardo Bonfanti, Clara Bonura, Giulia Patrizia Bracciolini, Mariella Bruzzese, Patrizia Bruzzi, Pietro Buono, Piera Buscarino, Francesco Cadario, Valeria Calcaterra, Elena Calzi, Marco Cappa, Roberta Cardani, Francesca Cardella, Giuliana Marcella Cardinale, Alberto Casertano, Valeria Castorani, Vittoria Cauvin, Valentina Cenciarelli, Franco Ceruti, Valentino Cherubini, Francesco Chiarelli, Giovanni Chiari, Stefano Cianfarani, Mario Cicchetti, Paola Cipriano, Dante Cirillo, Felice Citriniti, Maria Susanna Coccioli, Santino Confetto, Giovanna Contreas, Anna Coro, Antonella Correddu, Elisa Corsini, Antonino Crino′, Giuseppe d′Annunzio, Fiorella De Berardinis, Valeria De Donno, Gianpaolo De Filippo, Rosaria De Marco, Luisa De Sanctis, Elisabetta Del Duca, Maurizio Delvecchio, Annalisa Deodati, Procolo Di Bonito, Francesca Di Candia, Elena Faleschini, Valentina Fattorusso, Anna Favia, Giovanni Federico, Barbara Felappi, Mara Ferrari, Lucia Ferrito, Graziella Fichera, Franco Fontana, Elena Fornari, Roberto Franceschi, Francesca Franco, Adriana Franzese, Anna Paola Frongia, Giulio Frontino, Alberto Gaiero, Sabrina Maria Galassi, Francesco Gallo, Luigi Gargantini, Elisa Giani, Anna Jolanda Gortan, Vanna Graziani, Caterina Grosso, Antonella Gualtieri, Monica Guasti, Lucia Paola Guerraggio, Chiara Guzzetti, Dario Iafusco, Gennaro Iannicelli, Maria Laura Iezzi, Maria Giovanna Ignaccolo, Stefania Innaurato, Elena Inzaghi, Brunella Iovane, Lorenzo Iughetti, Peter Kaufmann, Alfonso La Loggia, Anna Giulia Lambertini, Rosa Lapolla, Anna Lasagni, Nicola Lazzaro, Pietro Lazzeroni, Lorenzo Lenzi, Riccardo Lera, Gabriella Levantini, Marilea Lezzi, Rosanna Lia, Alice Liguori, Donatella Lo Presti, Fortunato Lombardo, Antonella Lonero, Silvia Longhi, Antonella Lorubbio, Sonia Lucchesi, Rosella Maccioni, Maddalena Macedoni, Patrizia Cristiana Macellaro, Simona Filomena Madeo, Claudio Maffeis, Benedetta Mainetti, Giulio Maltoni, Chiara Mameli, Francesco Mammì, Maria Luisa Manca Bitti, Valentina Mancioppi, Melania Manco, Marco Marigliano, Monica Marino, Alberto Marsciani, Maria Cristina Matteoli, Elena Mazzali, Marta Minute, Nicola Minuto, Sara Monti, Anita Morandi, Gianfranco Morganti, Elisa Morotti, Enza Mozzillo, Gianluca Musolino, Francesca Olivieri, Federica Ortolani, Valentina Pampanini, Daniela Pardi, Filomena Pascarella, Bruno Pasquino, Stefano Passanisi, Ippolita Patrizia Patera, Annalisa Pedini, Maria Cristina Pennati, Sonia Peruzzi, Paola Peverelli, Giulia Pezzino, Barbara Piccini, Elvira Eugenia Rosaria Piccinno, Claudia Piona, Gavina Piredda, Alessia Piscopo, Carmelo Pistone, Erica Pozzi, Elena Prandi, Barbara Predieri, Sabrina Prudente, Anna Pulcina, Ivana Rabbone, Emioli Randazzo, Novella Rapini, Petra Reinstadler, Sara Riboni, Maria Rossella Ricciardi, Andrea Rigamonti, Carlo Ripoli, Virginia Rossi, Paolo Rossi, Irene Rutigliano, Alberto Sabbion, Alessandro Salvatoni, Caterina Salvo, Giuseppina Salzano, Mariateresa Sanseviero, Silvia Savastio, Rosanna Savini, Mariapiera Scanu, Andrea Enzo Scaramuzza, Riccardo Schiaffini, Maurizio Schiavone, Eleonardo Schieven, Mirella Scipione, Andrea Secco, Francesca Silvestri, Giulia Siri, Paola Sogno Valin, Silvia Sordelli, Daniele Spiri, Stefano Stagi, Filomena Andreina Stamati, Tosca Suprani, Valentina Talarico, Valentina Tiberi, Tiziana Antonia Lucia Timpanaro, Davide Tinti, Antonina Tirendi, Letizia Grazia Tomaselli, Sonia Toni, Cataldo Torelli, Gianluca Tornese, Michela Trada, Adolfo Andrea Trettene, Stefano Tumini, Marilena Tumminelli, Giuliana Valerio, Sara Vandelli, Claudia Ventrici, Maria Zampolli, Manuela Zanatta, Angela Zanfardino, Clara Zecchino, Silvia Zonca, Stefano Zucchini Acta Diabetologica, 2026
Unmet needs of Italian centers for pediatric diabetes care: analysis of a survey among pediatric diabetologists facing the national screening program for Type 1 Diabetes Marco Marigliano, Roberto Franceschi, Enza Mozzillo, Valentina Tiberi, Monica Marino, Giada Boccolini, Malgorzata Wasniewska, Maria Elizabeth Street, Maria Rosaria Licenziati, Riccardo Bonfanti, Felice Citriniti, Giuseppe D’Annunzio, Maria Carolina Salerno, Valentino Cherubini, , Claudia Arnaldi, Giulia Berioli, Adriana Bobbio, Giulia Bracciolini, Francesca Cardella, Giuliana Marcella Cardinale, Vittoria Cauvin, Maria Susanna Coccioli, Anna Corò, Francesco Costantino, Fiorella De Berardinis, Valeria De Donno, Luisa De Sanctis, Elena Faleschini, Barbara Felappi, Francesca Franco, Alberto Gaiero, Francesco Gallo, Vanna Graziani, Lucia Paola Gueraggio, Dario Iafusco, Antonio Iannilli, Stefania Innaurato, Brunella Iovane, Alfonso La Loggia, Anna Lasagni, Nicola Lazzaro, Donatella Lo Presti, Fortunato Lombardo, Claudio Maffeis, Benedetta Mainetti, Chiara Mameli, Gianfranco Meloni, Sara Monti, Carlo Moretti, Filomena Pascarella, Elvira Piccinno, Gavina Piredda, Carmelo Pistone, Barbara Predieri, Ivana Rabbone, Emioli Randazzo, Petra Reinstadler, Carlo Ripoli, Irene Rutigliano, Andrea Scaramuzza, Riccardo Schiaffini, Laura Serra, Silvia Sordelli, Filomena Stamati, Letizia Tomaselli, Sonia Toni, Stefano Tumini, Maria Zampolli, Stefano Zucchini Italian Journal of Pediatrics, 2025 Backgrounds The incidence of Type 1 Diabetes (T1D) in children and adolescents is increasing by 3–4% per year. Children and adolescents with T1D (CwD) should receive person-centered, specialized treatment from a multidisciplinary team to ensure appropriate care. Italy is the first to implement a countrywide T1D screening program, which will raise the need for funding for specialized pediatric care. The study aims to update the organization of the Italian Centers for pediatric diabetes care. Methods In 2022, members of the 59 Italian Centers following CwD were invited to complete an email survey regarding the Centers’ organization, characteristics, and activities. The questionnaire included information on responders, department organization, team composition, activities, and the organizational structures: department, ambulatory care services (AC), simple operational units (UOS), simple departmental operational units (UOSd), and complex operational units (UOC). Results The data collected referred to the year 2022. According to the results, 21,318 people with diabetes were treated. Of these, 19,643 subjects (92.1%) have T1D (16,672 were CwD), 387 (1,8%) have Type 2 Diabetes, and 1,288 (6,1%) have other forms of diabetes. Compared to the 2012 survey, a 13% decrease (from 68 to 59 Centers) in the number of pediatric Centers caring for CwD was observed with a parallel increase of total (+ 6.6%) and average (+ 22%) number of CwD per Center. The estimated prevalence of T1D has increased (1.4 vs. 1.7 per 1,000 CwD—2012 vs. 2022). A reduction in numbers for AC (-22%) and UOS (-35%) was observed, whereas UOSd/UOC increased by 50%. Almost 35% of the dietitians and 40% of the psychologists were not permanent members of the multidisciplinary diabetes team. Conclusions The observed decrease in the overall number of pediatric diabetes Centers, the reduction in specialized and dedicated HCPs, and the concurrent increase in the number of treated CwD in the last ten years indicate an alarming situation for pediatric diabetes treatment in Italy. Furthermore, the projected rise in CwD due to the National T1D screening program emphasizes the need for increased resources for specialized pediatric care of CwD at all stages.
Glucometrics and device satisfaction in children and adolescents with type 1 diabetes using different treatment modalities: A multicenter real-world observational study Valentino Cherubini, Andrea Fargalli, Claudia Arnaldi, Marta Bassi, Riccardo Bonfanti, Giulia Patrizia Bracciolini, Francesca Cardella, Sara Dal Bo, Maurizio Delvecchio, Francesca Di Candia, Roberto Franceschi, Sabrina Maria Galassi, Francesco Gallo, Vanna Graziani, Antonio Iannilli, Chiara Mameli, Marco Marigliano, Nicola Minuto, Sara Monti, Enza Mozzillo, Filomena Pascarella, Barbara Predieri, Ivana Rabbone, Rosalia Roppolo, Riccardo Schiaffini, Valentina Tiberi, Davide Tinti, Sonia Toni, Andrea Scaramuzza, Benedetta Vestrucci, Rosaria Gesuita Diabetes Research and Clinical Practice, 2024
Appropriate management of growth hormone deficiency during the age of transition: an Italian Delphi consensus statement S. Cannavò, M. Cappa, D. Ferone, A. M. Isidori, S. Loche, M. Salerno, M. Maghnie, Gianluca Aimaretti, Maria Rosaria Ambrosio, Simonetta Bellone, Manuela Caruso, Roberto Castello, Filippo Ceccato, Tania Cerbone, Valentino Cherubini, Eugenio de Carlo, Luisa De Sanctis, Silvia della Casa, Carolina Di Somma, Maria Felicia Faienza, Valentina Gasco, Rossella Gaudino, Claudio Giacomozzi, Claudia Giavoli, Laura Guazzarotti, Antonella Klain, Andrea Lania, Daniela Leonardi, Silvia Longhi, Lorenzo Lughetti, Maria Cristina Maggio, Gabriela Malgorzata Wasniewska, Chiara Mameli, Carolina Mauro, Emanuele Miraglia Del Giudice, Mario Carmine Antonio Palermo, Maria Parpagnoli, Luca Persani, Alba Pilotta, Gabriella Pozzobon, Vincenzo Rochira, Francesca Rota, Michele Sacco, Stefano Scarcella, Francesco Scavuzzo, Antonio Agostino Sinisi, Maria Elisabeth Street, Gianluca Tornese, and Journal of Endocrinological Investigation, 2023
Abnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy Francesca D’Addio, Ida Pastore, Cristian Loretelli, Alessandro Valderrama-Vasquez, Vera Usuelli, Emma Assi, Chiara Mameli, Maddalena Macedoni, Anna Maestroni, Antonio Rossi, Maria Elena Lunati, Paola Silvia Morpurgo, Alessandra Gandolfi, Laura Montefusco, Andrea Mario Bolla, Moufida Ben Nasr, Stefania Di Maggio, Lisa Melzi, Giovanni Staurenghi, Antonio Secchi, Stefania Bianchi Marzoli, Gianvincenzo Zuccotti, Paolo Fiorina Acta Diabetologica, 2022
Isolated childhood growth hormone deficiency: a 30-year experience on final height and a new prediction model Antonella Lonero, Massimo Giotta, Giulia Guerrini, Valeria Calcaterra, Elena Galazzi, Lorenzo Iughetti, Alessandra Cassio, Gabriela Malgorzata Wasniewska, Chiara Mameli, Gianluca Tornese, Mariacarolina Salerno, Valentino Cherubini, Manuela Caruso Nicoletti, Maria Elisabeth Street, Anna Grandone, Claudio Giacomozzi, Maria Felicia Faienza, Chiara Guzzetti, Simonetta Bellone, Maria Parpagnoli, Gianluca Musolino, Maria Cristina Maggio, Mauro Bozzola, Paolo Trerotoli, Maurizio Delvecchio, and Journal of Endocrinological Investigation, 2022
Corrigendum: The silent epidemic of diabetic ketoacidosis at diagnosis of type 1 diabetes in children and adolescents in italy during the covid-19 pandemic in 2020(Front. Endocrinol., (2022), 13, (878634), 10.3389/fendo.2022.878634) Valentino Cherubini, Monica Marino, Andrea E. Scaramuzza, Valentina Tiberi, Adriana Bobbio, Maurizio Delvecchio, Elvira Piccinno, Federica Ortolani, Stefania Innaurato, Barbara Felappi, Francesco Gallo, Carlo Ripoli, Maria Rossella Ricciardi, Filomena Pascarella, Filomena A. Stamati, Felice Citriniti, Claudia Arnaldi, Sara Monti, Vanna Graziani, Fiorella De Berardinis, Cosimo Giannini, Francesco Chiarelli, Maria Zampolli, Rosaria De Marco, Giulia Patrizia Bracciolini, Caterina Grosso, Valeria De Donno, Barbara Piccini, Sonia Toni, Susanna Coccioli, Giuliana Cardinale, Marta Bassi, Nicola Minuto, Giuseppe D’Annunzio, Claudio Maffeis, Marco Marigliano, Angela Zanfardino, Dario Iafusco, Assunta S. Rollato, Alessia Piscopo, Stefano Curto, Fortunato Lombardo, Bruno Bombaci, Silvia Sordelli, Chiara Mameli, Maddalena Macedoni, Andrea Rigamonti, Riccardo Bonfanti, Giulio Frontino, Barbara Predieri, Patrizia Bruzzi, Enza Mozzillo, Francesco Rosanio, Adriana Franzese, Gavina Piredda, Francesca Cardella, Brunella Iovane, Valeria Calcaterra, Maria Giulia Berioli, Anna Lasagni, Valentina Pampanini, Patrizia Ippolita Patera, Riccardo Schiaffini, Irene Rutigliano, Gianfranco Meloni, Luisa De Sanctis, Davide Tinti, Michela Trada, Lucia Paola Guerraggio, Roberto Franceschi, Vittoria Cauvin, Gianluca Tornese, Francesca Franco, Gianluca Musolino, Giulio Maltoni, Valentina Talarico, Antonio Iannilli, Lorenzo Lenzi, Maria Cristina Matteoli, Erica Pozzi, Carlo Moretti, Stefano Zucchini, Ivana Rabbone, Rosaria Gesuita Frontiers in Endocrinology, 2022
Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes Francesca D’Addio, Gianmarco Sabiu, Vera Usuelli, Emma Assi, Ahmed Abdelsalam, Anna Maestroni, Andy Joe Seelam, Moufida Ben Nasr, Cristian Loretelli, Davide Mileto, Giada Rossi, Ida Pastore, Laura Montefusco, Paola S. Morpurgo, Laura Plebani, Antonio Rossi, Enrica Chebat, Andrea M. Bolla, Maria Elena Lunati, Chiara Mameli, Maddalena Macedoni, Spinello Antinori, Stefano Rusconi, Maurizio Gallieni, Cesare Berra, Franco Folli, Massimo Galli, Maria Rita Gismondo, Gianvincenzo Zuccotti, Paolo Fiorina Diabetes, 2022
A nationwide survey of Italian pediatric diabetologists about COVID-19 vaccination in children and adolescents with type 1 diabetes Andrea E. Scaramuzza, Valentino Cherubini, Riccardo Schiaffini, Ivana Rabbone, Francesco Gallo, Graziella Fichera, Claudia Arnaldi, Riccardo Bonfanti, Fortunato Lombardo, Rosaria De Marco, Filomena Pascarella, Gianluca Tornese, Adriana Bobbio, Tosca Suprani, Nicola Minuto, Roberto Franceschi, Elvira Piccinno, Enza Mozzillo, Silvia Savastio, Barbara Piccini, Anna Paola Frongia, Chiara Mameli, Gianluca Musolino, Sonia Toni, Emioli Randazzo, Giulio Frontino, Maurizio Delvecchio, Paola Sogno Valin, Petra Reinstadler, Valeria Calcaterra, Luisa De Sanctis, Michela Trada, Maria Susanna Coccioli, Lucia P. Guerraggio, Felice Citriniti, Anna Lasagni, Irene Rutigliano, Filomena A. Stamati, Fiorella De Berardinis, Maria Zampolli, Giulio Maltoni, Elena Fornari, Carlo Ripoli, Alberto Gaiero, Silvia Sordelli, Giuseppe d’Annunzio, Barbara Predieri, Giuliana Cardinale, Francesca Cardella, Dario Iafusco, Anna Corò, Stefano Zucchini, Claudio Maffeis, Elisa Giani, Davide Tinti, Claudio Cavalli, and Acta Diabetologica, 2022
The Silent Epidemic of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Children and Adolescents in Italy During the COVID-19 Pandemic in 2020 Valentino Cherubini, Monica Marino, Andrea E. Scaramuzza, Valentina Tiberi, Adriana Bobbio, Maurizio Delvecchio, Elvira Piccinno, Federica Ortolani, Stefania Innaurato, Barbara Felappi, Francesco Gallo, Carlo Ripoli, Maria Rossella Ricciardi, Filomena Pascarella, Filomena A. Stamati, Felice Citriniti, Claudia Arnaldi, Sara Monti, Vanna Graziani, Fiorella De Berardinis, Cosimo Giannini, Francesco Chiarelli, Maria Zampolli, Rosaria De Marco, Giulia Patrizia Bracciolini, Caterina Grosso, Valeria De Donno, Barbara Piccini, Sonia Toni, Susanna Coccioli, Giuliana Cardinale, Marta Bassi, Nicola Minuto, Giuseppe D’Annunzio, Claudio Maffeis, Marco Marigliano, Angela Zanfardino, Dario Iafusco, Assunta S. Rollato, Alessia Piscopo, Stefano Curto, Fortunato Lombardo, Bruno Bombaci, Silvia Sordelli, Chiara Mameli, Maddalena Macedoni, Andrea Rigamonti, Riccardo Bonfanti, Giulio Frontino, Barbara Predieri, Patrizia Bruzzi, Enza Mozzillo, Francesco Rosanio, Adriana Franzese, Gavina Piredda, Francesca Cardella, Brunella Iovane, Valeria Calcaterra, Maria Giulia Berioli, Anna Lasagni, Valentina Pampanini, Patrizia Ippolita Patera, Riccardo Schiaffini, Irene Rutigliano, Gianfranco Meloni, Luisa De Sanctis, Davide Tinti, Michela Trada, Lucia Paola Guerraggio, Roberto Franceschi, Vittoria Cauvin, Gianluca Tornese, Francesca Franco, Gianluca Musolino, Giulio Maltoni, Valentina Talarico, Antonio Iannilli, Lorenzo Lenzi, Maria Cristina Matteoli, Erica Pozzi, Carlo Moretti, Stefano Zucchini, Ivana Rabbone, Rosaria Gesuita Frontiers in Endocrinology, 2022
Comment on "real-World Use of a New Hybrid Closed Loop Improves Glycemic Control in Youth with Type 1 Diabetes" by Messer et al. Andrea Enzo Scaramuzza, Riccardo Bonfanti, Valentino Cherubini, Marco Marigliano, Riccardo Schiaffini, Sonia Toni, Ivana Rabbone, Federico Abate Daga, Marta Bassi, Maria Giulia Berioli, Patrizia Bruzzi, Michela Calandretti, Chiara Carducci, Claudio Cavalli, Maurizio Delvecchio, Rosaria Gesuita, Sara Giorda, Dario Iafusco, Lorenzo Lenzi, Fortunato Lombardo, Donatella Lo Presti, Claudio Maffeis, Giulio Maltoni, Chiara Mameli, Monica Marino, Barbara Piccini, Nicola Minuto, Enza Mozzillo, Elvira Piccinno, Ciro Pignatiello, Barbara Predieri, Francesca Chiara Redaelli, Maria Rossella Ricciardi, Andrea Rigamonti, Carlo Ripoli, Francesco Maria Rosanio, Giuseppina Salzano, Silvia Savastio, Valentina Tiberi, Davide Tinti, Michela Trada, Sara Zanetta, Angela Zanfardino, Stefano Zucchini, and Diabetes Technology and Therapeutics, 2022
Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study Valentino Cherubini, Ivana Rabbone, Maria Giulia Berioli, Sara Giorda, Donatella Lo Presti, Giulio Maltoni, Chiara Mameli, Marco Marigliano, Monica Marino, Nicola Minuto, Enza Mozzillo, Elvira Piccinno, Barbara Predieri, Carlo Ripoli, Riccardo Schiaffini, Andrea Rigamonti, Giuseppina Salzano, Davide Tinti, Sonia Toni, Angela Zanfardino, Andrea E. Scaramuzza, Rosaria Gesuita, Valentina Tiberi, Silvia Savastio, Ciro Pigniatiello, Michela Trada, Stefano Zucchini, Francesca Chiara Redaelli, Claudio Maffeis, Marta Bassi, Francesco Maria Rosanio, Maurizio Delvecchio, Patrizia Buzzi, Maria Rossella Ricciardi, Chiara Carducci, Riccardo Bonfanti, Fortunato Lombardo, Barbara Piccini, Dario Iafusco, Michela Calandretti, Federico Abate Daga, and Diabetes Obesity and Metabolism, 2021
Type 1 diabetes onset in Lombardy region, Italy, during the COVID-19 pandemic: The double-wave occurrence Chiara Mameli, Andrea Scaramuzza, Maddalena Macedoni, Giuseppe Marano, Giulio Frontino, Ester Luconi, Ciretta Pelliccia, Barbara Felappi, Lucia Paola Guerraggio, Daniele Spiri, Patrizia Macellaro, Francesca Chiara Redaelli, Roberta Cardani, Maria Zampolli, Valeria Calcaterra, Silvia Sordelli, Elena Calzi, Anna Cogliardi, Ilaria Brambilla, Carmelo Pistone, Andrea Rigamonti, Patrizia Boracchi, Elia Biganzoli, Gian Vincenzo Zuccotti, Riccardo Bonfanti Eclinicalmedicine, 2021
The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis Evelyn Balsells, Ron Dagan, Inci Yildirim, Prabhu P. Gounder, Anneke Steens, Carmen Muñoz-Almagro, Chiara Mameli, Rama Kandasamy, Noga Givon Lavi, Laura Daprai, Arie van der Ende, Krzysztof Trzciński, Susan A. Nzenze, Susan Meiring, Dona Foster, Lisa R. Bulkow, Karen Rudolph, Ana Valero-Rello, Struan Ducker, Didrik Frimann Vestrheim, Anne von Gottberg, Stephen I. Pelton, GianVincenzo Zuccotti, Andrew J. Pollard, Elisabeth A.M. Sanders, Harry Campbell, Shabir A. Madhi, Harish Nair, Moe H. Kyaw Journal of Infection, 2018
Islet-derived EATP fuels autoreactive CD8+ T cells and facilitates the onset of type 1 diabetes Sara Tezza, Moufida Ben Nasr, Francesca D’Addio, Andrea Vergani, Vera Usuelli, Simonetta Falzoni, Roberto Bassi, Sergio Dellepiane, Carmen Fotino, Chiara Rossi, Anna Maestroni, Anna Solini, Domenico Corradi, Elisa Giani, Chiara Mameli, Federico Bertuzzi, Marcus G. Pezzolesi, Clive H. Wasserfall, Mark A. Atkinson, Ernst-Martin Füchtbauer, Camillo Ricordi, Franco Folli, Francesco Di Virgilio, Antonello Pileggi, Sirano Dhe-Paganon, Gian Vincenzo Zuccotti, Paolo Fiorina Diabetes, 2018
Prostaglandin E2 stimulates the expansion of regulatory hematopoietic stem and progenitor cells in type 1 diabetes Moufida Ben Nasr, Francesca D’Addio, Amir Mohammad Malvandi, Silvia Faravelli, Eduardo Castillo-Leon, Vera Usuelli, Francesca Rocchio, Teresa Letizia, Abdel Basset El Essawy, Emma Assi, Chiara Mameli, Elisa Giani, Maddalena Macedoni, Anna Maestroni, Alice Dassano, Cristian Loretelli, Moira Paroni, Giuseppe Cannalire, Giacomo Biasucci, Marco Sala, Alessandra Biffi, Gian Vincenzo Zuccotti, Paolo Fiorina Frontiers in Immunology, 2018
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Rotavirus gastroenteritis: Insights into the epidemiology and control of infection before and after vaccine introduction Rotavirus Infections Epidemiology Clinical Characteristics and Treatment Options, 2014
Breakfast: A multidisciplinary approach Antonio Affinita, Loredana Catalani, Giovanna Cecchetto, Gianfranco De Lorenzo, Dario Dilillo, et al. Italian Journal of Pediatrics, 2013
In reply Andrea E. Scaramuzza, Gian Luca Tadini, Chiara Mameli, Alessandra De Palma, Gian Vincenzo Zuccotti Archives of Pediatrics and Adolescent Medicine, 2010
Picture of the month Chiara Mameli, Andrea E. Scaramuzza, Gian Luca Tadini, Sara Riboni, Alessandra De Palma, et al. Archives of Pediatrics and Adolescent Medicine, 2009
