Lisete Michelini

Scopus Publications

Increased absorptive transcytosis and tight junction weakness in heart failure are equally corrected by exercise training and losartan
Hiviny de Ataides Raquel, Mariana Makuch-Martins, Sany M. Perego, Gustavo S. Masson, Leonardo Jensen, et al.
Clinical Science, 2025
Reduced ventricular function, renin–angiotensin system up-regulation, and sympathoexcitation are hallmarks of heart failure (HF). Recently, we showed that blood–brain barrier (BBB) lesion within autonomic nuclei contributes to autonomic imbalance and that exercise training (T) normalizes BBB function and improves autonomic control. We sought now to identify the mechanism(s) involved in both HF-induced lesion and exercise-induced correction. Wistar rats submitted to coronary artery ligation were, after the development of HF, assigned to losartan (Los) or vehicle (Veh) treatments and simultaneously submitted to T or sedentary (S) protocol. After hemodynamic/autonomic recordings and evaluation of BBB permeability, brains were harvested for ultrastructural analyses of the barrier (tight junctions’ [TJs] tightness and vesicles trafficking) within capillaries of the hypothalamic paraventricular nucleus. Local angiotensin II (Ang II) expression and activation of microglial cells (IBA-1 immunofluorescence) were also evaluated. High sympathetic activity and pressure variability, reduced parasympathetic control of the heart, elevated BBB permeability, high vesicular trafficking, and TJ weakness exhibited by Veh-S rats were equally corrected in Veh-T, Los-S, and Los-T groups. The increased paraventricular hypothalamic nucleus (PVN) Ang II expression and IBA-1 density in Veh-S group were similarly reduced by T, Los and combination of both. Ang II, colocalized with microglia AT1 receptors, induced their remodeling from disease-associated phenotype in Veh-S rats to homeostatic-surveilling conditions in the other groups. All measured parameters exhibited strong correlations with Ang II availability. Data indicated that changes in PVN Ang II availability induced by HF, exercise, and Los are the key regulator of transcellular and paracellular transport across the BBB.
Enalapril induces muscle epigenetic changes and contributes to prevent a decline in running capacity in spontaneously hypertensive rats
Denis Carlos dos Santos, Fernando Henrique Ferrari Alves, Luiz Fernando Veríssimo, Hiviny Ataides Raquel, Vinicius Lucca Volpini, et al.
Archives of Gerontology and Geriatrics, 2025
Exercise-induced neuroplasticity in autonomic nuclei restores the cardiac vagal tone and baroreflex dysfunction in aged hypertensive rats
Lais Oliveira Dellacqua, Paula Magalhães Gomes, Julia Santos Batista, Lisete Compagno Michelini, Vagner Roberto Antunes
Journal of Applied Physiology, 2024
Exercise training reduces high blood pressure and cardiovascular autonomic modulation in aged hypertensive rats. The dysfunction in the baroreflex sensitivity and impaired parasympathetic tone to the heart of aged hypertensive rats are restored by exercise training. Exercise induces beneficial neuroplasticity in the brain nuclei involved with autonomic control of cardiovascular function of aged hypertensive rats.
Angiotensin II, blood–brain barrier permeability, and microglia interplay during the transition from pre-to hypertensive phase in spontaneously hypertensive rats
Mariana Makuch-Martins, Camilla G. Vieira-Morais, Sany M. Perego, Adriana Ruggeri, Alexandre Ceroni, et al.
Frontiers in Physiology, 2024
BackgroundHypertension is characterized by upregulation of the renin–angiotensin system, increased blood–brain barrier (BBB) permeability, microglia activation within autonomic nuclei, and an intense sympathoexcitation. There is no information on the interplay of these events during the development of neurogenic hypertension. We sought to identify the interaction and time-course changes of Ang II availability, barrier dysfunction, microglia activation, and autonomic imbalance within autonomic areas during the development of neurogenic hypertension.MethodsSequential changes of hemodynamic/autonomic parameters, BBB permeability, microglia structure/density (IBA-1), and angiotensin II (Ang II) immunofluorescence were evaluated within the paraventricular hypothalamic nucleus, nucleus of the solitary tract, and rostral ventrolateral medulla of Wistar and spontaneously hypertensive rats (SHRs) aged 4 weeks, 5 weeks, 6 weeks, 8 weeks, and 12 weeks. The somatosensory cortex and hypoglossal nucleus were also analyzed as non-autonomic control areas.ResultsIncreased brain Ang II availability (4th–5th week) was the first observed change, followed by the incipient BBB leakage and increased microglia density (6th week). From the 5th–6th weeks on, BBB leakage, Ang II, and IBA-1 densities increased continuously, allowing a parallel increase in both Ang II-microglia colocalization and the transition of microglial cells from highly ramified in the basal surveillant condition (4th–5th week) to shorter process arbors, fewer endpoints, and enlarged soma in the disease-associate condition (6th week to the 12th week). Simultaneously with increased Ang II-microglia colocalization and microglia morphologic phenotypic changes, sympathetic activity and pressure variability increased, autonomic control deteriorated, and blood pressure increased. These responses were not specific for autonomic nuclei but also occurred at a lower magnitude in the somatosensory cortex and hypoglossal nucleus, indicating the predominance of hypertension-induced effects on autonomic areas. No changes were observed in age-matched controls where Ang II density did not change.ConclusionBrain Ang II density is the initial stimulus to drive coordinated changes in BBB permeability and microglial reactivity. Increased BBB dysfunction allows access of plasma Ang II and increases its local availability and the colocalization and activation of microglial cells. It is a potent stimulus to augments vasomotor sympathetic activity, autonomic imbalance, and pressure elevation during the establishment of hypertension.
Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries
Sany M. Perego, Hiviny A. Raquel, Vanessa B. Candido, Gustavo S. Masson, Mariana M. Martins, et al.
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2023
Hypertension augments while exercise training corrects the increased vesicle trafficking (transcytosis) across the blood-brain barrier (BBB) within preautonomic areas and the autonomic imbalance. There is no information on a possible mechanism(s) conditioning these effects. Knowing that Mfsd2a is the major transporter of docosahexaenoic acid (DHA) and that Mfsd2a knockout mice exhibited leaky BBB, we sought to identify its possible involvement in hypertension- and exercise-induced transcytosis across the BBB. Spontaneously hypertensive rats (SHR) and Wistar rats were submitted to treadmill training (T) or kept sedentary (S) for 4 wk. Resting hemodynamic/autonomic parameters were recorded in conscious chronically cannulated rats. BBB permeability within the hypothalamic paraventricular nucleus (PVN) was evaluated in anesthetized rats. Brains were harvested for Mfsd2a and caveolin-1 (an essential protein for vesicle formation) expression. SHR-S versus Wistar-S exhibited elevated arterial pressure (AP) and heart rate (HR), increased vasomotor sympathetic activity, reduced cardiac parasympathetic activity, greater pressure variability, reduced HR variability, and depressed baroreflex control. SHR-S also showed increased BBB permeability, reduced Mfsd2a, and increased caveolin-1 expression. SHR-T versus SHR-S exhibited increased Mfsd2a density, reduced caveolin-1 protein expression, and normalized PVN BBB permeability, which were accompanied by resting bradycardia, partial AP drop, reduced sympathetic and normalized cardiac parasympathetic activity, increased HR variability, and reduced pressure variability. No changes were observed in Wistar-T versus Wistar-S. Training is an efficient tool to rescue Mfsd2a expression, which by transporting DHA into the endothelial cell reduces caveolin-1 availability and vesicles’ formation. Exercise-induced Mfsd2a normalization is an important mechanism to correct both BBB function and autonomic control in hypertensive subjects.
Blood-brain barrier lesion - a novel determinant of autonomic imbalance in heart failure and the effects of exercise training
Hiviny de Ataides Raquel, Sany M. Pérego, Gustavo S. Masson, Leonardo Jensen, Alison Colquhoun, et al.
Clinical Science, 2023
Heart failure (HF) is characterized by reduced ventricular function, compensatory activation of neurohormonal mechanisms and marked autonomic imbalance. Exercise training (T) is effective to reduce neurohormonal activation but the mechanism underlying the autonomic dysfunction remains elusive. Knowing that blood–brain barrier (BBB) lesion contributes to autonomic imbalance, we sought now to investigate its involvement in HF- and exercise-induced changes of autonomic control. Wistar rats submitted to coronary artery ligation or SHAM surgery were assigned to T or sedentary (S) protocol for 8 weeks. After hemodynamic/autonomic recordings and evaluation of BBB permeability, brains were harvesting for ultrastructural analysis of BBB constituents, measurement of vesicles trafficking and tight junction’s (TJ) tightness across the BBB (transmission electron microscopy) and caveolin-1 and claudin-5 immunofluorescence within autonomic brain areas. HF-S rats versus SHAM-S exhibited reduced blood pressure, augmented vasomotor sympathetic activity, increased pressure and reduced heart rate variability, and, depressed reflex sensitivity. HF-S also presented increased caveolin-1 expression, augmented vesicle trafficking and a weak TJ (reduced TJ extension/capillary border), which determined increased BBB permeability. In contrast, exercise restored BBB permeability, reduced caveolin-1 content, normalized vesicles counting/capillary, augmented claudin-5 expression, increased TJ tightness and selectivity simultaneously with the normalization of both blood pressure and autonomic balance. Data indicate that BBB dysfunction within autonomic nuclei (increased transcytosis and weak TJ allowing entrance of plasma constituents into the brain parenchyma) underlies the autonomic imbalance in HF. Data also disclose that exercise training corrects both transcytosis and paracellular transport and improves autonomic control even in the persistence of cardiac dysfunction.
Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normalized autonomic control of the circulation
Vanessa B. Candido, Sany M. Perego, Alexandre Ceroni, Martin Metzger, Alison Colquhoun, et al.
Frontiers in Physiology, 2023
Introduction: Chronic hypertension is accompanied by either blood-brain barrier (BBB) leakage and autonomic dysfunction. There is no consensus on the mechanism determining increased BBB permeability within autonomic areas. While some reports suggested tight junction’s breakdown, others indicated the involvement of transcytosis rather than paracellular transport changes. Interestingly, exercise training was able to restore both BBB permeability and autonomic control of the circulation. We sought now to clarify the mechanism(s) governing hypertension- and exercise-induced BBB permeability.Methods: Spontaneously hypertensive rats (SHR) and normotensive controls submitted to 4-week aerobic training (T) or sedentary protocol (S) were chronically cannulated for baseline hemodynamic and autonomic recordings and evaluation of BBB permeability. Brains were harvested for measurement of BBB function (FITC-10 kDa leakage), ultrastructural analysis of BBB constituents (transmission electron microscopy) and caveolin-1 expression (immunofluorescence).Results: In SHR-S the increased pressure, augmented sympathetic vasomotor activity, higher sympathetic and lower parasympathetic modulation of the heart and the reduced baroreflex sensitivity were accompanied by robust FITC-10kDa leakage, large increase in transcytotic vesicles number/capillary, but no change in tight junctions’ density within the paraventricular nucleus of the hypothalamus, the nucleus of the solitary tract and the rostral ventrolateral medulla. SHR-T exhibited restored BBB permeability and normalized vesicles counting/capillary simultaneously with a normal autonomic modulation of heart and vessels, resting bradycardia and partial pressure reduction. Caveolin-1 expression ratified the counting of transcellular, not other cytoplasmatic vesicles. Additionally, T caused in both groups significant increases in tight junctions’ extension/capillary border.Discussion: Data indicate that transcytosis, not the paracellular transport, is the primary mechanism underlying both hypertension- and exercise-induced BBB permeability changes within autonomic areas. The reduced BBB permeability contributes to normalize the autonomic control of the circulation, which suppresses pressure variability and reduces the occurrence of end-organ damage in the trained SHR. Data also disclose that hypertension does not change but exercise training strengthens the resistance of the paracellular pathway in both strains.
Exercise training improves cardiovascular control in sinoaortic denervated SHR by reducing the elevated angiotensin II and augmenting angiotensin-(1−7) availability within autonomic and neuroendocrine PVN nuclei
Hiviny A. Raquel, Louisi A. Manica, Alexandre Ceroni, Lisete C. Michelini
Peptides, 2022
Perfusion of Brain Preautonomic Areas in Hypertension: Compensatory Absence of Capillary Rarefaction and Protective Effects of Exercise Training
Maria Tereza Jordão, Alexandre Ceroni, Lisete C. Michelini
Frontiers in Physiology, 2021
Remodeling of capillary rarefaction and deleterious arteries are characteristic hallmarks of hypertension that are partially corrected by exercise training. In addition, experimental evidence showed capillary rarefaction within the brain cortex and reduced cerebral blood flow. There is no information on hypertension- and exercise-induced effects on capillary profile and function within preautonomic nuclei. We sought now to evaluate the effects of hypertension and exercise training (T) on the capillary network within hypothalamic paraventricular (PVN) and solitary tract (NTS) nuclei, and on the remodeling of brain arteries. Age-matched spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY), submitted to moderate T or kept sedentary (S) for three months, were chronically cannulated for hemodynamic recordings at rest. Rats were anesthetized for i.v. administration of fluorescein isothiocyanate (FITC)-dextran (capillary volume/density measurements) or 4% paraformaldehyde perfusion (basilar, middle, and posterior arteries' morphometry) followed by brain harvesting and processing. Other groups of conscious rats had carotid blood flow (CBF, ultrasound flowmeter) acquired simultaneously with hemodynamic recordings at rest and exercise. SHR-S exhibited elevated pressure and heart rate, reduced CBF, increased wall/lumen ratio of arteries, but no capillary rarefaction within the PVN and NTS. T improved performance gain and caused resting bradycardia in both groups; reduction of pressure and sympathetic vasomotor activity and normalization of the wall/lumen ratio were only observed in SHR-T. T groups responded with marked PVN and NTS capillary angiogenesis and augmented CBF during exercise; to avoid overperfusion at rest, reduced basal CBF was observed only in WKY-T. Data indicated that the absence of SHR-S capillary rarefaction and the intense SHR-T angiogenesis within autonomic areas associated with correction of deleterious arteries' remodeling are essential adjustments to hypertension and exercise training, respectively. These adaptive responses maintain adequate baseline perfusion in SHR-S and SHR-T preautonomic nuclei, augmenting it in exercised rats when a well-coordinated autonomic control is required.
Transcytosis within PVN capillaries: A mechanism determining both hypertension-induced blood-brain barrier dysfunction and exercise-induced correction
Matheus Garcia Fragas, Vanessa Brito Cândido, Gustavo Gastão Davanzo, Carla Rocha-Santos, Alexandre Ceroni, et al.
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2021
Although hypertension disrupts the blood-brain barrier (BBB) integrity within the paraventricular nucleus of hypothalamus (PVN) and increases the leakage into the brain parenchyma, exercise training (T) was shown to correct it. Since there is scarce and contradictory information on the mechanism(s) determining hypertension-induced BBB deficit and nothing is known about T-induced improvement, we sought to evaluate the paracellular and transcellular transport across the BBB within the PVN in both conditions. Spontaneously hypertensive rats (SHR) and WKY submitted to 4-wk aerobic T or sedentary (S) protocol were chronically catheterized for hemodynamic recordings at rest and intra-arterial administration of dyes (Rhodamine-dextran 70 kDa + FITC-dextran 10 kDa). Brains were harvesting for FITC leakage examination, qPCR evaluation of different BBB constituents and protein expression of caveolin-1 and claudin-5, the main markers of transcytosis and paracellular transport, respectively. Hypertension was characterized by increased arterial pressure and heart rate, augmented sympathetic modulation of heart and vessels, and reduced cardiac parasympathetic control, marked FITC extravasation into the PVN which was accompanied by increased caveolin-1 gene and protein expression, without changes in claudin-5 and others tight junctions’ components. SHR-T vs. SHR-S showed a partial pressure reduction, resting bradycardia, improvement of autonomic control of the circulation simultaneously with correction of both FITC leakage and caveolin-1 expression; there was a significant increase in claudin-5 expression. Caveolin-1 content was strongly correlated with improved autonomic control after exercise. Data indicated that within the PVN the transcytosis is the main mechanism governing both hypertension-induced BBB leakage, as well as the exercise-induced correction.
Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: Evidence from a novel CARNS1 knockout rat model
Lívia de Souza Gonçalves, Lucas Peixoto Sales, Tiemi Raquel Saito, Juliane Cruz Campos, Alan Lins Fernandes, et al.
Redox Biology, 2021
Swimming training reduces iNOS expression, augments the antioxidant defense and reduces sympathetic responsiveness in the rostral ventrolateral medulla of normotensive male rats
Hiviny de Ataides Raquel, Carla Fabiana Souza Guazelli, Waldiceu A. Verri, Lisete C. Michelini, Marli Cardoso Martins-Pinge
Brain Research Bulletin, 2021
The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial
Carine Teles Sangaleti, Keyla Yukari Katayama, Kátia De Angelis, Tércio Lemos de Moraes, Amanda Aparecida Araújo, et al.
Frontiers in Immunology, 2021
Molecular Pathways Involved in Aerobic Exercise Training Enhance Vascular Relaxation
Suliana M. Paula, Tiago Fernandes, Gisele K. Couto, Maria T. Jordão, Edilamar M. Oliveira, et al.
Medicine and Science in Sports and Exercise, 2020
Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure
Jhansi Dyavanapalli, Jeannette Rodriguez, Carla Rocha dos Santos, Joan B. Escobar, Mary Kate Dwyer, et al.
Jacc Basic to Translational Science, 2020
Activity-Dependent Neuroplastic Changes in Autonomic Circuitry Modulating Cardiovascular Control: The Essential Role of Baroreceptors and Chemoreceptors Signaling
Carla Rocha-Santos, Douglas Costa Braga, Alexandre Ceroni, Lisete C. Michelini
Frontiers in Physiology, 2020
Training-induced deactivation of the AT1 receptor pathway drives autonomic control and heart remodeling during the transition from the pre-to hypertensive phase in spontaneously hypertensive rats
Tassia Santos Rodrigues da Costa, Gustavo Santos Masson, Rosangela Aparecida dos Santos Eichler, Juliane Cristina de Souza Silva, Silvia Lacchini, et al.
Circulation Journal, 2020
Standardization of a new non-invasive device for assessment of arterial stiffness in rats: Correlation with age-related arteries’ structure
Mayara F. Fabricio, Maria T. Jordão, Danyelle S. Miotto, Thalles F.R. Ruiz, Carlos A. Vicentini, et al.
Methodsx, 2020
Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension
Nilson C. Ferreira‐Junior, Adriana Ruggeri, Sebastião D. Silva, Thais T. Zampieri, Alexandre Ceroni, et al.
Physiological Reports, 2019
Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states
Roger A. Dampney, Lisete C. Michelini, De-Pei Li, Hui-Lin Pan
American Journal of Physiology Heart and Circulatory Physiology, 2018
The essential role of hypothalamic paraventricular nucleus nNOS in the modulation of autonomic control in exercised rats
Hiviny de Ataides Raquel, Nathalia Zerbinatti Ferreira, Bruno Fernando Cruz Lucchetti, Bárbara Falquetto, Phileno Pinge-Filho, et al.
Nitric Oxide Biology and Chemistry, 2018
Exercise training abrogates age-dependent loss of hypothalamic oxytocinergic circuitry and maintains high parasympathetic activity
C. R. Santos, A. Ruggeri, A. Ceroni, L. C. Michelini
Journal of Neuroendocrinology, 2018
Maintenance of blood-brain barrier integrity in hypertension: A novel benefit of exercise training for autonomic control
Leila Buttler, Maria T. Jordão, Matheus G. Fragas, Adriana Ruggeri, Alexandre Ceroni, et al.
Frontiers in Physiology, 2017
Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction
Sebastião D. Silva, Zaira P. Jara, Roseli Peres, Larissa S. Lima, Cristóforo Scavone, et al.
Plos One, 2017
Intrauterine growth restriction-induced deleterious adaptations in endothelial progenitor cells: Possible mechanism to impair endothelial function
V. Oliveira, L. V. de Souza, T. Fernandes, S. D. S. Junior, M. H. C. de Carvalho, et al.
Journal of Developmental Origins of Health and Disease, 2017
Moderate treadmill exercise training improves cardiovascular and nitrergic response and resistance to Trypanosoma cruzi infection in mice
Bruno F. C. Lucchetti, Nágela G. Zanluqui, Hiviny de Ataides Raquel, Maria I. Lovo-Martins, Vera L. H. Tatakihara, et al.
Frontiers in Physiology, 2017
Intrauterine growth restriction increases circulating mitochondrial DNA and Toll-like receptor 9 expression in adult offspring: Could aerobic training counteract these adaptations
V. Oliveira, S. D. Silva Junior, M. H. C. de Carvalho, E. H. Akamine, L. C. Michelini, et al.
Journal of Developmental Origins of Health and Disease, 2017
Experimental evidences supporting training-induced benefits in spontaneously hypertensive rats
Gustavo S. Masson, Lisete C. Michelini
Advances in Experimental Medicine and Biology, 2017
Experimental evidences supporting the benefits of exercise training in heart failure
Marcelo H. A. Ichige, Marcelo G. Pereira, Patrícia C. Brum, Lisete C. Michelini
Advances in Experimental Medicine and Biology, 2017
Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure
Marcelo H. A. Ichige, Carla R. Santos, Camila P. Jordão, Alexandre Ceroni, Carlos E. Negrão, et al.
Journal of Physiology, 2016
Ovarian hormone deprivation reduces oxytocin expression in paraventricular nucleus preautonomic neurons and correlates with baroreflex impairment in rats
Vitor U. De Melo, Rayssa R. M. Saldanha, Carla R. Dos Santos, Josiane De Campos Cruz, Vitor A. Lira, et al.
Frontiers in Physiology, 2016
Swimming training modulates nitric oxide-glutamate interaction in the rostral ventrolateral medulla in normotensive conscious rats
Hiviny de A. Raquel, Gustavo S. Masson, Barbara Falquetto Barna, Nágela G. Zanluqui, Phileno Pinge-Filho, et al.
Frontiers in Physiology, 2016
Early training-induced reduction of Angiotensinogen in autonomic areas-the main effect of exercise on brain Renin-Angiotensin system in hypertensive rats
Laiali Jurdi Chaar, Tatiana Pereira Alves, Alvaro Martins Batista Junior, Lisete Compagno Michelini
Plos One, 2015
Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR
Gustavo Santos Masson, Anand R. Nair, Pedro Paulo Silva Soares, Lisete Compagno Michelini, Joseph Francis
American Journal of Physiology Heart and Circulatory Physiology, 2015
Neural control of circulation and exercise: A translational approach disclosing interactions between central command, arterial baroreflex, and muscle metaboreflex
Lisete C. Michelini, Donal S. O'Leary, Peter B. Raven, Antonio C. L. Nóbrega
American Journal of Physiology Heart and Circulatory Physiology, 2015
Endocrine-autonomic linkages
Celia D. Sladek, Lisete C. Michelini, Nina S. Stachenfeld, Javier E. Stern, Janice H. Urban
Comprehensive Physiology, 2015
Downregulation of the vascular renin-angiotensin system by aerobic training-Focus on the balance between vasoconstrictor and vasodilator axes
Sebastião D. Silva Jr., Thais T. Zampieri, Adriana Ruggeri, Alexandre Ceroni, Danielle S. Aragão, et al.
Circulation Journal, 2015
Toll-like receptor 4 promotes autonomic dysfunction, inflammation and microglia activation in the hypothalamic paraventricular nucleus: Role of endoplasmic reticulum stress
Gustavo S. Masson, Anand R. Nair, Rahul B. Dange, Pedro Paulo Silva-Soares, Lisete C. Michelini, et al.
Plos One, 2015
Influence of aerobic training on the reduced vasoconstriction to angiotensin ii in rats exposed to intrauterine growth restriction: Possible role of oxidative stress and at2 receptor of angiotensin II
Vanessa Oliveira, Eliana Hiromi Akamine, Maria Helena C. Carvalho, Lisete Compagno Michelini, Zuleica Bruno Fortes, et al.
Plos One, 2014
Time-dependent effects of training on cardiovascular control in spontaneously hypertensive rats: Role for Brain oxidative stress and inflammation and baroreflex sensitivity
Gustavo S. Masson, Tassia S. R. Costa, Lidia Yshii, Denise C. Fernandes, Pedro Paulo Silva Soares, et al.
Plos One, 2014
The angiotensin-melatonin axis
Luciana A. Campos, Jose Cipolla-Neto, Fernanda G. Amaral, Lisete C. Michelini, Michael Bader, et al.
International Journal of Hypertension, 2013
Melatonin modulates baroreflex control via area postrema
Luciana A. Campos, Jose Cipolla‐Neto, Lisete C. Michelini
Brain and Behavior, 2013
Peripheral chemoreceptors mediate training-induced plasticity in paraventricular nucleus pre-autonomic oxytocinergic neurons
Josiane C. Cruz, Marina T. Cavalleri, Alexandre Ceroni, Lisete C. Michelini
Experimental Physiology, 2013
Exercise training normalizes an increased neuronal excitability of NTS-projecting neurons of the hypothalamic paraventricular nucleus in hypertensive rats
Javier E. Stern, Patrick M. Sonner, Sook Jin Son, Fabiana C. P. Silva, Keshia Jackson, et al.
Journal of Neurophysiology, 2012
Baroreceptor-mediated activation of sympathetic nerve activity to salivary glands
Robinson Sabino-Silva, Alexandre Ceroni, Tadachika Koganezawa, Lisete C. Michelini, Ubiratan F. Machado, et al.
Physiology and Behavior, 2012
Exercise training restores hypertension-induced changes in the elastic tissue of the thoracic aorta
Maria Tereza Jordão, Fernando V.L. Ladd, Antonio Augusto Coppi, Renato P. Chopard, Lisete C. Michelini
Journal of Vascular Research, 2011
Afferent signaling drives oxytocinergic preautonomic neurons and mediates training-induced plasticity
Marina T. Cavalleri, Katia Burgi, Josiane C. Cruz, Maria T. Jordão, Alexandre Ceroni, et al.
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2011
Tyrosine hydroxylase immunoreactivity as indicator of sympathetic activity: Simultaneous evaluation in different tissues of hypertensive rats
Katia Burgi, Marina T. Cavalleri, Adilson S. Alves, Luiz R. G. Britto, Vagner R. Antunes, et al.
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2011
Effect of gender on training-induced vascular remodeling in SHR
S.L. Amaral, L.C. Michelini
Brazilian Journal of Medical and Biological Research, 2011
Cardiac benefits of exercise training in aging spontaneously hypertensive rats
Luciana V. Rossoni, Raphael A.F. Oliveira, Rene R. Caffaro, Maria Miana, David Sanz-Rosa, et al.
Journal of Hypertension, 2011
Exercise-induced neuronal plasticity in central autonomic networks: Role in cardiovascular control
Lisete C. Michelini, Javier E. Stern
Experimental Physiology, 2009
Brainstem oxytocinergic modulation of heart rate control in rats: Effects of hypertension and exercise training: Experimental Physiology
Keila T. Higa‐Taniguchi, Jorge V. C. Felix, Lisete C. Michelini
Experimental Physiology, 2009
Chronic absence of baroreceptor inputs prevents training-induced cardiovascular adjustments in normotensive and spontaneously hypertensive rats
Alexandre Ceroni, Laiali J. Chaar, Rafael L. Bombein, Lisete C. Michelini
Experimental Physiology, 2009
Is gender crucial for cardiovascular adjustments induced by exercise training in female spontaneously hypertensive rats?
Rosemeire Coimbra, Lylian S. Sanchez, Janaina M. Potenza, Luciana V. Rossoni, Sandra Lia Amaral, et al.
Hypertension, 2008
Time course of training-induced microcirculatory changes and of VEGF expression in skeletal muscles of spontaneously hypertensive female rats
S.L. Amaral, L.S. Sanchez, A.J.B.A. Chang, L.V. Rossoni, L.C. Michelini
Brazilian Journal of Medical and Biological Research, 2008
Training-induced pressure fall in spontaneously hypertensive rats is associated with reduced angiotensinogen mRNA expression within the nucleus tractus solitarii
Jorge Vinicius Cestari Felix, Lisete Compagno Michelini
Hypertension, 2007
The NTS and integration of cardiovascular control during exercise in normotensive and hypertensive individuals
Lisete Compagno Michelini
Current Hypertension Reports, 2007
Differential effects of vasopressinergic and oxytocinergic pre-autonomic neurons on circulatory control: Reflex mechanisms and changes during exercise
Lisete Compagno Michelini
Clinical and Experimental Pharmacology and Physiology, 2007
Exercise training-induced remodeling of paraventricular nucleus (nor)adrenergic innervation in normotensive and hypertensive rats
Keila T. Higa-Taniguchi, Fabiana C. P. Silva, Helaine M. V. Silva, Lisete C. Michelini, Javier E. Stern
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2007
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight
Daniela F. Bertelli, Eliana P. Araújo, Maristela Cesquini, Graziela R. Stoppa, Miriam Gasparotto-Contessotto, et al.
Endocrinology, 2006
International student exchange and the medical curriculum: Evaluation of a medical sciences translational physiology course in Brazil
Mariana Morris, T. David Jones, Maria Jose Alves Rocha, Rubens Fazan, Mark W. Chapleau, et al.
American Journal of Physiology Advances in Physiology Education, 2006
Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus
Keshia Jackson, Helaine M. Vieira Silva, Wenfeng Zhang, Lisete C. Michelini, Javier E. Stern
Journal of Neurophysiology, 2005
Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain.
Adriano S. Martins, Alessandra Crescenzi, Javier E. Stern, Silvana Bordin, Lisete C. Michelini
Hypertension, 2005
Endogenous Angiotensin and Pressure Modulate Brain Angiotensinogen and AT1A mRNA Expression
Carine T. Sangaleti, Alessandra Crescenzi, Lisete C. Michelini
Hypertension, 2004
Oxytocinergic regulation of cardiovascular function: Studies in oxytocin-deficient mice
Lisete C. Michelini, Marialuisa C. Marcelo, Janet Amico, Mariana Morris
American Journal of Physiology Heart and Circulatory Physiology, 2003
Training-Induced, Pressure-Lowering Effect in SHR: Wide Effects on Circulatory Profile of Exercised and Nonexercised Muscles
Ronaldo Meira Melo, Eduardo Martinho, Lisete Compagno Michelini
Hypertension, 2003
Locally synthesized angiotensin modulates pineal melatonin generation
Ovidiu Baltatu, Solange Castro Afeche, Sabrina Heloísa José dos Santos, Luciana Aparecida Campos, Roseli Barbosa, et al.
Journal of Neurochemistry, 2002
Baroreflex control of heart rate by oxytocin in the solitary-vagal complex
Keila T. Higa, Eliana Mori, Fabiano F. Viana, Mariana Morris, Lisete C. Michelini
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2002
Oxytocin in the NTS: A new modulator of cardiovascular control during exercise
LISETE COMPAGNO MICHELINI
Annals of the New York Academy of Sciences, 2001
Exercise training causes skeletal muscle venular growth and alters hemodynamic responses in spontaneously hypertensive rats
Sandra L. Amaral, Neide P. Silveira, Telma M. T. Zorn, Lisete C. Michelini
Journal of Hypertension, 2001
Receptor changes in the nucleus tractus solitarii of the rat after exercise training
CAIO GARCIA G. TIAGO DE SOUZA, LISETE C. MICHELINI, D??BORA R. FIOR-CHADI
Medicine and Science in Sports and Exercise, 2001
Chronic AT(1) receptor blockade alters autonomic balance and sympathetic responses in hypertension.
Simone M.M.S. Bezerra, Claudia M. dos Santos, Edson D. Moreira, Eduardo M. Krieger, Lisete C. Michelini
Hypertension, 2001
Exercise training normalizes wall-to-lumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats
Sandra L. Amaral, Telma M.T. Zorn, Lisete C. Michelini
Journal of Hypertension, 2000
Central oxytocin modulates exercise-induced tachycardia
Douglas C. Braga, Eliana Mori, Keila T. Higa, Mariana Morris, Lisete C. Michelini
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2000
Endogenous vasopressin modulates the cardiovascular responses to exercise
LISETE COMPAGNO MICHELINI, MARIANA MORRIS
Annals of the New York Academy of Sciences, 1999
Endogenous vasopressin and the central control of heart rate during dynamic exercise
L.C. Michelini
Brazilian Journal of Medical and Biological Research, 1998
Role of endogenous nitric oxide in the nucleus tratus solitarii on baroreflex control of heart rate in spontaneously hypertensive rats
Vera Pontieri, Maria Kelly Venezuela, Cristóforo Scavone, Lisete C. Michelini
Journal of Hypertension, 1998
Chronic AT1 receptor blockade alters aortic nerve activity in hypertension
Claudia M. dos Santos, Edson D. Moreira, Eduardo M. Krieger, Lisete C. Michelini
Hypertension, 1998
Validation of transit-time flowmetry for chronic measurements of regional blood flow in resting and exercising rats
S.L. Amaral, L.C. Michelini
Brazilian Journal of Medical and Biological Research, 1997
Modulation of exercise tachycardia by vasopressin in the nucleus tractus solitarii
Daniel L. Dufloth, Mariana Morris, Lisete C. Michelini
American Journal of Physiology Regulatory Integrative and Comparative Physiology, 1997
In vivo adaptive responses of the aorta to hypertension and aging
M. Sumitani, A. M. Cabral, L. C. Michelini, E. M. Krieger
American Journal of Physiology Heart and Circulatory Physiology, 1997
Losartan improves baroreflex control of heart rate of coarcted hypertensive rats
C. M. Santos, V. Pontieri, M. Leomil Neto, L. C. Michelini
American Journal of Physiology Heart and Circulatory Physiology, 1995
Vasopressin in the nucleus tractus solitarius: a modulator of baroreceptor reflex control of heart rate.
Brazilian Journal of Medical and Biological Research Revista Brasileira De Pesquisas Medicas E Biologicas Sociedade Brasileira De Biofisica Et Al, 1994
Baroreceptor reflex control of heart rate during development of coarctation hypertension
Hypertension, 1992
Angiotensin II as a modulator of baroreceptor reflexes in the brainstem of conscious rats
L C Michelini, L G Bonagamba
Hypertension, 1990
Baroreceptor reflex modulation by vasopressin microinjected into the nucleus tractus solitarii of conscious rats
L C Michelini, L G Bonagamba
Hypertension, 1988
Aortic caliber changes during development of hypertension in freely moving rats
L. C. Michelini, E. M. Krieger
American Journal of Physiology Heart and Circulatory Physiology, 1986
Long-term analysis of aortic dynamics in growing conscious rats
Hypertension, 1986
Long-term analysis of aortic dynamics in growing conscious rats
Hypertension, 1986
Area postrema lesions augment the pressor activity of centrally administered vasopressin
Lisete C. Michelini, Karen L. Barnes, Carlos M. Ferrario
Clinical and Experimental Hypertension, 1986
Importance of the time course of aortic diastolic calibre dilation for baroreceptor resetting in acute hypertension
Journal of Hypertension, 1984
Arginine vasopressin modulates the central action of angiotensin II in the dog
L C Michelini, K L Barnes, C M Ferrario
Hypertension, 1983
Resetting of the baroreceptors.
International Review of Physiology, 1982
Mechanoelastic properties of the aorta in chronically hypertensive conscious rats
L C Michelini, E M Krieger
Hypertension, 1981

Lisete Michelini

EDUCATION

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS