Gloria Castells Carles
@uab.cat
Scopus Publications
- A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
Patricia Galvez-Martin, Cristina Soto-Fernandez, Jessica Romero-Rueda, Jesus Cabañas, Anna Torrent, Gloria Castells, Daniel Martinez-Puig
International Journal of Molecular Sciences, 2023
Hyaluronic acid (HA) and proteoglycans (such as dermatan sulphate (DS) and chondroitin sulphate (CS)) are the main components of the extracellular matrix of the skin, along with collagen and elastin. These components decrease with age, which implies a loss of skin moisture causing wrinkles, sagging and aging. Currently, the external and internal administration of effective ingredients that can reach the epidermis and dermis is the main alternative for combating skin aging. The objective of this work was to extract, characterise and evaluate the potential of an HA matrix ingredient to support anti-aging. The HA matrix was isolated and purified from rooster comb and characterised physicochemically and molecularly. In addition, its regenerative, anti-aging and antioxidant potential and intestinal absorption were evaluated. The results show that the HA matrix is composed of 67% HA, with an average molecular weight of 1.3 MDa; 12% sulphated glycosaminoglycans, including DS and CS; 17% protein, including collagen (10.4%); and water. The in vitro evaluation of the HA matrix’s biological activity showed regenerative properties in both fibroblasts and keratinocytes, as well as moisturising, anti-aging and antioxidant effects. Furthermore, the results suggest that the HA matrix could be absorbed in the intestine, implying a potential oral as well as topical use for skin care, either as an ingredient in a nutraceutical or a cosmetic product. - Influence of a pig respiratory disease on the pharmacokinetic behaviour of amoxicillin after oral ad libitum administration in medicated feed
C. GODOY, G. CASTELLS, G. MARTÍ, B. P. S. CAPECE, F. PÉREZ, H. COLOM, C. CRISTÒFOL
Journal of Veterinary Pharmacology and Therapeutics, 2011
The pharmacokinetic properties of amoxicillin in healthy and respiratory-diseased pigs were studied, after ad libitum administration of medicated feed. In addition, amoxicillin dose linearity and drug penetration into respiratory tract tissues were evaluated in diseased animals. The respiratory disease involves porcine reproductive and respiratory syndrome virus and bacterial agents such as Pasteurella multocida, Bordetella bronchiseptica and Streptococcus suis. Typical clinical signs and gross lesions of respiratory disease were observed. The plasma pharmacokinetic analysis was performed by means of a noncompartmental approach. After single intravenous bolus administration of amoxicillin to healthy pigs, the steady-state volume of distribution was 0.61 L/kg, the total plasma clearance was 0.83 L/h/kg and the mean residence time was 0.81 h. After oral bolus administration, the mean absorption time was 1.6 h and the peak plasma concentration (3.09 μg/mL) reached at 1.1 h postadministration. The oral bioavailability was 34%. For oral ad libitum administration, plasma concentration-time profiles were related to the feeding behaviour. Plasma concentrations at steady-state were established between 12 and 120 h. The pharmacokinetic parameters calculated (C(maxss) , C(minss) , C(avss) and AUC(24ss) ) showed significantly lower values in healthy pigs compared to diseased animals. This was in accordance with the significantly higher amoxicillin bioavailability (44.7% vs. 14.1%) and longer absorption period observed in diseased pigs. Amoxicillin dose linearity in diseased animals was established in a dose range of 4-18 mg/kg. On the other hand, tissue distribution ratio in diseased animals was 0.65 for bronchial mucosa, 0.48 for lung tissue and 0.38 for lymph nodes. Our results suggest that the pharmacokinetic properties and disposition of amoxicillin can be influenced by the disease state or by related factors such as changes in the gastrointestinal transit. - Characterization of the degradation performance of the sulfamethazine antibiotic by photo-Fenton process
Montserrat Pérez-Moya, Moisès Graells, Gloria Castells, Jordi Amigó, Esther Ortega, Guillem Buhigas, Leonardo M. Pérez, Héctor D. Mansilla
Water Research, 2010 - Pharmacokinetic behaviour of perphenazine in sheep after intramuscular administration of a long-acting formulation
C. PEDERNERA-ROMANO, J. L. RUIZ-de-la-TORRE, G. CASTELLS, X. MANTECA, C. CRISTÒFOL
Journal of Veterinary Pharmacology and Therapeutics, 2009 - Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats
B.P.S. Capece, S.M.S. Afonso, R. Lazáro, M. Harun, C. Godoy, G. Castells, C. Cristòfol
Research in Veterinary Science, 2009 - Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats
Bettencourt P.S. Capece, Gloria Castells, Carlo Godoy, Margarita Arboix, Carles Cristòfol
Veterinary Journal, 2008 - HPLC quantification of perphenazine in sheep plasma: Application to a pharmacokinetic study
Cecilia Pedernera, José Luis Ruiz, Glòria Castells, Xavier Manteca, Carles Cristòfol
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2007 - Determination of porphyrins and biliverdin in bile and excreta of birds by a single liquid chromatography-ultraviolet detection analysis
R MATEO, G CASTELLS, A GREEN, C GODOY, C CRISTOFOL
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2004 - Albendazole sulphoxide enantiomers in pregnant rats embryo concentrations and developmental toxicity
B.P.S. Capece, M. Navarro, T. Arcalis, G. Castells, L. Toribio, F. Perez, A. Carretero, J. Ruberte, M. Arboix, C. Cristòfol
Veterinary Journal, 2003 - Residue depletion of thiamphenicol in the sea-bass
L. INTORRE, G. CASTELLS, C. CRISTOFOL, S. BERTINI, G. SOLDANI, M. ARBOIX
Journal of Veterinary Pharmacology and Therapeutics, 2002
The residue depletion of thiamphenicol (TAP) was investigated in the sea-bass (Dicentrarchus labrax) after 5 days' treatment with medicated food at a dose of 15 or 30 mg/kg bw/day. Fish were sampled for blood and muscle + skin from 3 h until 14 days after treatment. Thiamphenicol concentrations were assayed by high performance liquid chromatography. Thiamphenicol concentrations measured 3 h after stopping treatment were 0.77 microg/mL and 0.91 (15 mg/kg dose) or 1.32 microg/mL and 1.47 microg/g (30 mg/kg dose), in plasma and muscle + skin, respectively. After a withdrawal of 3 days, plasma and tissue concentrations were: 0.08 microg/mL and 0.03 microg/g (lower dose) or 0.12 microg/mL and 0.06 microg/g (higher dose), respectively. Thiamphenicol was not detectable either in plasma or in tissues on days 7, 10 and 14 following withdrawal of the medicated food. Based on maximum residue levels (MRL) for TAP in fin fish, established at 50 microg/kg for muscle and skin in natural proportions, a withdrawal period of 5 and 6 days is proposed, after treatment at 15 or 30 mg/kg of TAP with medicated feed pellets, respectively, to avoid the presence of violative residues in the edible tissues of the sea-bass. - Pharmacokinetics of doramectin and ivermectin after oral administration in horses
R. Pérez, I. Cabezas, C. Godoy, L. Rubilar, L. Muñoz, M. Arboix, G. Castells, M. Alvinerie
Veterinary Journal, 2002 - Placental transfer of albendazole sulphoxide enantiomers in sheep
B.P.S. Capece, R. Pérez, A. Andaluz, F. Pérez, F. Garcia, G. Castells, M. Arboix, C. Cristòfol
Veterinary Journal, 2002 - Allometric analysis of thiamphenicol disposition among seven mammalian species
G. Castells, B. P. S. Capece, F. Perez, G. Marti, M. Arboix, C. Cristofol
Journal of Veterinary Pharmacology and Therapeutics, 2001 - Effect of ruminal microflora on the biotransformation of netobimin, albendazole, albendazole sulfoxide, and albendazole sulfoxide enantiomers in an artificial rumen
B P Capece, S Calsamiglia, G Castells, M Arboix, C Cristòfol
Journal of Animal Science, 2001 - Pharmacokinetic behaviour of albendazole sulphoxide enantiomers in male and female sheep
B.P.S. Capece, G. Castells, F. Pérez, M. Arboix, C. Cristòfol
Veterinary Research Communications, 2000 - Thiamphenicol disposition in pigs
G CASTELLS, C PRATS, G.E.L KORCHI, B PÉREZ, M ARBOIX, C CRISTÒFOL, G MARTÌ
Research in Veterinary Science, 1999 - Pharmacokinetics of thiamphenicol in dogs
American Journal of Veterinary Research, 1998
