Dr. Laxmikant Zawar
@hrpatelpharmacy.co.in
Associate Professor, Pharmaceutics
H R Patel Institute of Pharmaceutical Education and Research
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacy, Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics
Scopus Publications
Scopus Publications
Pooja Mahajan, Sopan Nangare, Amol Patil, Pankaj Jain, and Laxmikan Zawar
Elsevier BV
Amol Patil, Sopan Nangare, Pooja Mahajan, Pankaj Jain, and Laxmikant Zawar
Elsevier BV
BHUPESH DIGAMBAR PATIL, , SOPAN NAMDEV NANGARE, LAXMIKANT RAMVALLABH ZAWAR, , and
Institutul de Chimie Macromoleculara Petru Poni
The present work anticipated crystallinity-tuned silk fibroin (SFIB)-sodium alginate floating microbeads (MB) as a candidate for nevirapine (NEV) sustained release. Briefly, crystallinity tuning was accomplished using solvent annealing. The changes in structural conformation of SFIB were validated using FTIR spectroscopy. Here, the tangent baseline method revealed changes in crystallinity of floating NEV-loaded SFIB-MB. Importantly, solvent annealing offers conversion of amorphous ‘α-helix’ to crystalline ‘β-sheet’ of SFIB, helping to modify drug release from the matrix of SFIB-sodium alginate. As well, NEV-loaded SFIB-MB demonstrated good floating profile. The NEV-loaded SFIB-MB with ethanol (ETH-6) annealing for 6 hours shows 25.853% drug release at 12 hours (pH = 1.2), compared to untreated NEV-loaded SFIB-MB (65.132%, 12 hours, log p < 0.0001). The release kinetics of batch ETH-6 revealed first-order release kinetics and Fickian diffusion (n = 0.468) was found to be the drug diffusion mechanism. Therefore, crystallinity-modified floating NEV-loaded SFIB-based MB will open a new door for modified drug delivery.
Pratiksha Devkar, Sopan Nangare, Laxmikant Zawar, Nitin Shirsath, Piyush Bafna, and Pankaj Jain
Elsevier BV
Vipul Chaudhari, Shraddha Tawade, Sopan Nangare, Kirti Rajput, Nitin Shirsath, Piyush Bafna, and Laxmikant Zawar
EManuscript Technologies
Background: The implementation of chitosan as an enhanced vehicle for drug delivery is an interesting domain in the pharmaceutical dosage form. The combination of commonly accessible natural polysaccharides like gum may provide a new arrangement of dosage forms such as polyelectrolyte complex. Such modern improvements facilitate the modulated release of active, which can be beneficial in avoiding adverse consequences. There have been no reports on chitosan and sesbania gum-based polyelectrolyte complexes for drug delivery applications to date. Objectives: The chitosan-sesbania gum polyelectrolyte complex was developed for modified drug delivery of diclofenac sodium. Materials and Methods: pH-responsive polyelectrolyte complexes were accomplished utilizing the coacervation technique. It forms complex due to the capability of chitosan amine groups and sesbania gum carboxylic functionality. Results: The SEM analysis assured the aggregated polyhedral shape particles with a smooth surface of the final polyelectrolyte complex. The Diffractogram of the polyelectrolyte complex resulted in an amorphous form of diclofenac. The polyelectrolyte complex batch (B:3) showed satisfactory drug entrapment capabilities. It showed 88.96% of the drug release in 8 hr (pH 6.8). Importantly, it is because of the unprotonated condition of sesbania gum containing hydrophilic functionality that offers boosted hydrogen bonding via interaction with dissolution medium containing water molecules. Therefore, it offers the insertion of water molecules into a complex followed by the swelling of a matrix. Conclusion: The developed chitosan-sesbania gum polyelectrolyte complex offers a pH-responsive sustained release of diclofenac sodium. In the future, chitosan and sesbania gum-based polyelectrolyte complex can be preferred as an innovative drug carrier for diclofenac sodium delivery.
Kirti Rajput, Shraddha Tawade, Sopan Nangare, Nitin Shirsath, Sanjaykumar Bari, and Laxmikant Zawar
Elsevier BV
Laxmikant Zawar, Gaurav Patil, Nitin Shirsath, and Piyush Bafna
BSP Books Private Limited
Solubility is one of the major concerns in a lot of drug formulations. Since the majority of new drug molecules belong to the BCS II (Biopharmaceutical Classification of Drug) they often lead to poor bioavailability and ultimately affect the drug's effectiveness. The majority of new drug molecules are insoluble and hence poorly bioavailable. Because of these limitations, the proportion of newly discovered drugs reaching the market is decreasing. Nano-suspension emerges as one of the novel solutions for these problems. As it helps in delivering poorly water-soluble drugs, due to their all-around features and unique advantages. The distinctive features of nanosuspensions allow them to be used in a variety of dosage forms, including mucoadhesive hydrogels, nanogels, etc. The present review article provides information regarding the introduction to nanosuspensions, the advantages, and disadvantages of nanosuspensions, different methods of their preparations, and numerous practical applications in drug delivery.
Mohini Patil, Samadhan Patil, Vijay L. Maheshwari, Laxmikant Zawar, and Ravindra H. Patil
Springer Nature Singapore
Nitin Shirsath, Dipak Marathe, Priyanka Jaiswal, and Laxmikant Zawar
EManuscript Technologies
Laxmikant R. Zawar and Sanjay B. Bari
Bentham Science Publishers Ltd.
AIMS AND BACKGROUND
The objective of the study was to improve the bioavailability of poorly soluble repaglinide (RPG) by preparing nanosuspension with poloxamer 188 using high pressure homogenization (HPH). The recent patents on nanocrystals (US20150337006A1) facilitated selection of drug and polymer.
METHODS
Suspensions containing dissimilar sized particles were prepared by ultrasonication and HPH. The prepared aqueous suspensions were lyophilized and then characterized. Further, the dried aqueous suspensions were evaluated for drug content, solubility, in vitro dissolution, oral bioavailability study and stability study.
RESULTS
RPG nanoparticles size, polydispersity index (PDI) and zeta potential were found to be 280.8 ± 15 nm, 0.279 ± 0.04 and - 25.81 ± 1.6mV, respectively. DSC and XRD results showed that RPG particles in aqueous suspensions were present in a crystalline state; however, RPG nanoparticles exhibited decreased lattice energy due to smaller particle size. Nanoparticles prepared by HPH exhibited significant improvements in solubility and dissolution rate. Oral bioavailability was found to be enhanced by 1.93 fold in comparison with that of plain RPG. The nanosuspension was found to be stable when stored at 5°C ± 3°C.
CONCLUSION
The outcomes of the study revealed significant enhancement in dissolution rate and oral bioavailability of RPG due to size reduction to nano range by HPH.
Payal H. Patil, Pooja R. Wankhede, Hitendra S. Mahajan, and Laxmikant R. Zawar
Bentham Science Publishers Ltd.
AIMS AND BACKGROUND
The fundamental objective of current study was to encapsulate Aripiprazole (ARP) within Pluronic F127 micelles to improve its aqueous solubility. The recent patents on Aripiprazole (JP2013136621) and micelles (WO2016004369A1) facilitated selection of drug and polymer.
MATERIALS AND METHODS
The drug-laden micelles were fabricated using thin-film hydration technique. Optimization of the micellar formulation was done by using response surface method (RSM). The Pluronic F127 concentration of 150 mg and 75 rpm rotational speed of rotary evaporator were found to be optimized conditions for formulating micelles.
RESULTS
The prepared batches were further characterized for PDI (polydispersity index), zeta potential, % DLC (% Drug loading content), % EE (% Entrapment Efficiency) and % drug release study; results of these parameters were found to be 0.228, -4.04 mV and 76.50 % and 18.56 % respectively. It was observed from the In vitro release study that 97.37 ± 1.81 % drug had released from micelles after 20h which were found about thrice as compared to that of pure drug. The optimized ARP micellar formulation was characterized using DSC (Differential Scanning Colorimetry), FT-IR (Fourier Transformed Infrared Spectroscopy), P-XRD (Powdered X-ray Diffraction Study) and TEM (Transmission Electronic Microscopy) studies. ARP-loaded micelles displayed a hydrodynamic diameter of 170.3 nm and a sphere-shaped morphology as determined by dynamic light scattering as well as TEM study.
CONCLUSION
It is concluded that the prepared polymeric micellar system has an excellent potential to be used as a delivery carrier for Aripiprazole with increased solubility.
Zawar
Journal of Applied Pharmaceutical Science
The present investigation studies the effect of water swellable polymer hydroxylpropylmethyl cellulose (HPMC K4M, Methocel) on in vitro release of ondansetron from suppositories. Suppositories were prepared by using mixture of Poloxamer 407 and Poloxamer 188 hydrophilic bases. Suppositories containing 16 mg of ondansetron were prepared by fusion method. Weight variation, content uniformity, breaking (hardness), disintegration time, melting point and liquefaction time of the formulations were determined. In vitro release test was carried out according to USP XXII basket method. In vitro release data demonstrates ondansetron release from suppositories up to 12hrs and follows the zero order kinetics from poloxamer mixture based suppositories.
Laxmikant Ramvallabh Zawar and Sanjay Baburao Bari
Pharmaceutical Society of Japan
The influence of microwave technology on the in vitro dissolution rate and in vivo antihyperglycemic activity of a poorly water soluble drug, repaglinide (RG) was studied. Solid dispersions were prepared by conventional fusion method and microwave method using poloxamer 188. The dispersions were characterized by solubility study, dissolution study, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). Microwave generated solid dispersions exhibited remarkable improvement in solubility and dissolution rate compared to that of pure RG. Results of DSC, XRD and SEM study showed conversion of crystalline form of RG to amorphous form. In vivo studies revealed that the microwave generated solid dispersion showed significant improvements in antihyperglycemic activity as compared to RG alone, thus confirming the advantage of improved pharmacological activity of RG by microwave method. In conclusion, microwave method could be considered as simple, efficient and solvent free promising alternative method to prepare solid dispersion of poorly water soluble drug RG with significant enhancement in solubility, dissolution rate and antihyperglycemic activity.