Novel 3-aminoimidazole[1,2-α]pyridine/pyrazine analogues: Synthesis and biological evaluation as anticancer agents Isra’ Al-Qadi, Michel Hanania, Saied M Soliman, Nurul Izzaty Hassan, Wan Nurfadhilah Zaharim, Saki Raheem, Nawaf Al-Maharik Journal of Molecular Structure, 2025 Herein, we report the synthesis of novel derivatives of 3-aminoimidazole[1,2-α]pyridine/pyrazines via a one-pot Groebke-Blackburn-Bienayme Three-Component Reaction (GBB-3CR) as promising anticancer agents. The synthesised compounds were evaluated for efficacy against three cancer cell lines (MCF-7, HT-29, and B16F10) and one normal cell (MEF). Among the thirteen compounds tested, only compounds 16 and 18 significantly inhibited cancer cells, with high selectivity. Compound 16 showed strong activity against HT-29 (IC 50 = 12.98 ± 0.40 µM) and B16F10 (IC 50 = 27.54 ± 1.26 µM), whereas compound 18 , bearing a 2,4-difluorophenyl substitution at C-2 and a p -fluorophenyl amine at C-3, was most effective against MCF-7 (IC 50 = 9.60 ± 3.09 µM). X-ray crystallographic analysis for compounds 9 and 20 confirmed their molecular structures and revealed significant differences in twist angles (87.59° in 9 vs 75.65° in 20 ) and π-π stacking interactions (C…C: 3.206-3.394 Å). Hirshfeld surface analysis highlighted key intermolecular forces governing crystal packing, with potential implications for solubility, stability, and molecular interactions with biological targets. Density functional theory (DFT) calculations further suggested that compound 18’s larger HOMO-LUMO gap enhances electronic stability and molecular recognition, contributing to its selective cytotoxicity. These findings highlight the structural and electronic factors influencing the anticancer activity of imidazo[1,2-α]pyridine/pyrazine derivatives and provide insights for further optimisation of their therapeutic potential.
Synthesis and Characterization of 5,15 A2-Type Porphyrin, Metalloporphyrin and Preliminary Study on Carbon Dioxide Adsorption Nuur Haziqah Mohd Radzuan, Zaitun Ghazali, Nurul Izzaty Hassan, Mohd Bakri Bakar, Siti Aishah Hasbullah, Muntaz Abu Bakar Sains Malaysiana, 2025 Porphyrins are among the most extensively studied compounds in chemistry due to their remarkable stability, optical, and photophysical properties. In recent years, advancements in their diverse applications have driven the exploration of porphyrins with different functional groups, allowing for more specific applications. Nowadays, a greater focus is being placed on the development of materials for capturing and converting carbon dioxide (CO2) into value-added products. Despite their promising features, the application of porphyrins in carbon dioxide adsorption has been hindered by their initially low adsorption capacity compared to other traditional porous materials, such as microporous carbons and zeolites. Modifications to porphyrins, such as the introduction of diverse functional groups and the incorporation of metal centers are promising, as they may enhance the CO2 adsorption performance of porphyrin-based materials. Therefore, this study focuses on the synthesis of 5,15 A2-type porphyrin and its metalloporphyrin derivatives, along with a preliminary evaluation of synthesized porphyrin’s carbon dioxide adsorption ability. The synthesized porphyrins were characterized via nuclear magnetic resonance spectroscopy (NMR) and UV-visible spectroscopy. The yield for porphyrin varied from 23% to 35%, while metalloporphyrin achieved a yield of 99%. A preliminary study of carbon dioxide adsorption ability of porphyrin and metalloporphyrin showed that the insertion of metal into the center of porphyrin macrocyclic ring enhances the binding affinity and improves adsorption capacity. The Freundlich isotherm showed the presence of heterogeneous adsorption sites and possible multilayer adsorption of CO2 onto the porphyrin’s surface. Additionally, due to the ability of metalloporphyrin to adsorb CO2, metalloporphyrin has the potential to serve as a building block for the integration of porphyrin into hybrid materials such as metal-organic frameworks (MOFs) and covalent-organic framework (COFs), by enhancing their structural stability and CO2 performance.
Emerging Biomarkers and Electrochemical Biosensors for Early Detection of Premature Coronary Artery Disease Nanthini Mageswaran, Sarah Husnaini Zainal, Nurul Izzaty Hassan, Nurul Huda Abd Karim, Noor Akmal Shareela Ismail Diagnostics, 2025 Coronary artery disease (CAD) is one of the primary causes of morbidity and death worldwide. Premature CAD (pCAD) is the term used to describe the 3–10% of CAD occurrences that occur in people under 45 worldwide. Diagnostic difficulties arise from the different risk factor profiles of pCAD and late-onset CAD. Better cardiovascular risk prediction in younger populations has been made possible by the development of biomarker detection tools. This can be applied to a diagnostic tool, including electrochemical biosensors, which have been predicted to be instrumental because of their adaptability for point-of-care applications for quicker diagnoses. These biosensors provide efficient, scalable, and reasonably priced solutions for the quick identification and tracking of CAD. Multiplex biomarker detection has been adopted as a viable approach for early diagnosis and risk assessment due to the constraints of using a single biomarker for pCAD diagnosis. Thus, this study looks at current developments in biosensing technology and discusses established and new cardiac biomarker panels for pCAD identification.
Electrochemically reduced graphene oxide integrated with carboxylated-8-carboxamidoquinoline: A platform for highly sensitive voltammetric detection of Zn(II) ion by screen-printed carbon electrode Ling Ling Tan, Nur Syamimi Mohamad, Nurul Izzaty Hassan, Choo Ta Goh Plos One, 2025 Zinc has been demonstrated to boost immune response during SAR-CoV-2 infection, where it prevents coronavirus multiplication. Clinical investigations have testified to its beneficial effects on respiratory health and its deficiency may reduce immune function. A highly sensitive detection of Zn(II) ion via differential pulse voltammetry (DPV) utilizing an environmentally friendly modified screen-printed carbon electrode (SPCE) of electrochemically reduced graphene oxide (ErGO) embedded with carboxylated-8-carboxamidoquinoline (CACQ) as Zn(II) chelating ligand. The green CACQ/ErGO-modified SPCE was characterized by spectroscopy techniques, such as Fourier-transform infrared (FTIR) spectroscopy, Raman spectroscopy, and field-emission scanning electron microscopy with energy dispersive X-ray (FESEM-EDX). The modified electrode-solution interface was studied by electrochemical cyclic voltammetry (CV) and DPV methods. The CACQ-modified wrinkled ErGO electrode conferred a large surface-to-volume ratio with multiple binding sites resulting in greater opportunity for multiple dative covalent binding events with Zn(II) via coordination chemistry, and considerably accelerated the electron transfer rate at the electrode surface. The green Zn(II) sensor demonstrated a quick response time (60 s), broad linear range [1 pM-1 μM Zn(II) ion], a limit of detection (LOD) of 0.53 pM, 35 days of storage period (≥80% of its initial response retained), good reproducibility [relative standard deviation (RSD) = 3.4%], and repeatability (RSD = 4.4%). The developed electrode was applied to determine Zn(II) ion concentration in dietary supplement samples, and the results were in good agreement with those obtained from inductively coupled plasma-mass spectrometry (ICP-MS).
Omics Data Integration of Rhynchophorus Ferrugineus Reveals High-Potential Targeted Pathways for the Development of Pest Control Management Ahmad‐Faris Seman‐Kamarulzaman, Nor Azlan Nor Muhammad, Nurul Wahida Othman, Johari Jalinas, Nurul Izzaty Hassan, Nur Lina Rahmat, Maizom Hassan Archives of Insect Biochemistry and Physiology, 2025 Rhynchophorus ferrugineus (Olivier, 1790) (Coleoptera: Dryophthoridae), commonly known as the red palm weevil (RPW), is a globally significant pest that threatens economically important palm trees. Its cryptic infestation behavior leads to irreversible damage and eventual host plant death. Current control methods using broad‐spectrum insecticides are largely ineffective due to resistance development and their adverse effects on nontarget organisms, necessitating novel strategies. This study integrates proteomics and transcriptomics data to explore the molecular landscape of RPW and identify pathways for targeted pest management. A total of 16,954 transcripts and 983 proteins were identified across three developmental stages (larvae, male adults, and female adults), with a notable decline in protein numbers from larvae to adult. Differential expression analysis revealed 7540 proteins varying significantly between developmental stages. Through subtractive analysis, 218 proteins meeting stringent inclusion and exclusion criteria were identified. These proteins underwent pathway enrichment analysis, mapping to 39 enriched pathways (p‐value and an FDR of < 0.01). Among these, two pathways involving three key enzymes were highlighted as high‐potential targets for developing insect‐specific insecticides and diet‐specific control strategies. This is the first comprehensive proteomics study analyzing the whole body of RPW across its developmental stages. The findings emphasize critical pathways, their enzyme components, and the regulation of these enzymes, offering novel insights for sustainable and targeted pest management solutions.
Synthesis and Molecular Docking Studies of Pyrano[2,3-c] Pyrazole-3-Carboxylates as Potential Inhibitors of Plasmodium Falciparum Malaysian Journal of Chemistry, 2020
Photo-activated self-healing bio-based polyurethanes Chee Sien Wong, Nurul Izzati Hassan, Mohd Sukor Su’ait, M. Angels Pelach Serra, Jose Alberto Mendez Gonzalez, Luis Angel Granda, Khairiah Haji Badri Industrial Crops and Products, 2019
Quantitative analysis of aluminium (III) ion using alizarin red S and artificial neural network Sains Malaysiana, 2007
RECENT SCHOLAR PUBLICATIONS
Structural insights into additives for dye-sensitized solar cell (DSSC) electrolytes MA Shamsuddin, NI Hassan, MS Su’ait, S Ibrahim Solar Energy 304, 114199 , 2026 2026 Citations: 1
Recent developments in synthesis and antimalarial activities of chalcone hybrids L Ravindar, L Revathi, CF Wen, NI Hassan, YL Lau Bioorganic & Medicinal Chemistry, 118512 , 2025 2025 Citations: 4
Novel 3-aminoimidazole [1, 2-α] pyridine/pyrazine analogues: Synthesis and biological evaluation as anticancer agents M Hanania, SM Soliman, NI Hassan, WN Zaharim, S Raheem, ... Journal of Molecular Structure 1340, 142549 , 2025 2025 Citations: 1
Exploring the complex nexus of climate change, food security, and public health: A scientific perspective through bibliometric analysis NIM Ali, NS Mohamad, NI Hassan, Z Kallas, MAC Mustapa, KC Lam, ... Environmental Science & Policy 170, 104118 , 2025 2025 Citations: 3
A comparative evaluation of augmented reality and virtual reality on chemistry experiment learning in higher level education MC Lam, NAA Majid, NI Hassan, NN Mobarak, SY Tan, H Hashim, ... Multimedia Tools and Applications 84 (27), 32887-32926 , 2025 2025 Citations: 3
Exploring β-carboline hybrids and their derivatives: A review on synthesis and anticancer efficiency NF Sulaiman, SZ Zulkifli, AS Saaidin, R Lekkala, NI Hassan, NH Pungot European Journal of Medicinal Chemistry 288, 117412 , 2025 2025 Citations: 10
Emerging biomarkers and electrochemical biosensors for early detection of premature coronary artery disease N Mageswaran, SH Zainal, NI Hassan, NH Abd Karim, NAS Ismail Diagnostics 15 (7), 940 , 2025 2025 Citations: 13
Electrochemically reduced graphene oxide integrated with carboxylated-8-carboxamidoquinoline: A platform for highly sensitive voltammetric detection of Zn (II) ion by screen … LL Tan, NS Mohamad, NI Hassan, CT Goh Plos one 20 (2), e0315974 , 2025 2025 Citations: 3
Omics Data Integration of Rhynchophorus ferrugineus Reveals High‐Potential Targeted Pathways for the Development of Pest Control Management AF Seman‐Kamarulzaman, NAN Muhammad, NW Othman, J Jalinas, ... Archives of Insect Biochemistry and Physiology 118 (2), e70039 , 2025 2025
Design and synthesis of pyrano [2, 3-c] pyrazole-4-aminoquinoline hybrids as effective antimalarial compounds R Lekkala, YH Ng, SR Feroz, NAZB Norazmi, AH Ali, SA Hasbullah, ... European Journal of Medicinal Chemistry 279, 116828 , 2024 2024 Citations: 10
A solid-state sensor based on nanosilica/methylcellulose composite and chromoionophore 8-carboxamidoquinoline derivative as an optode pellet for Zinc (II) ion NS Mohamad, NI Hassan, CT Goh, LL Tan Journal of Molecular Structure 1317, 139151 , 2024 2024 Citations: 2
Pyridine and pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development L Ravindar, SA Hasbullah, KP Rakesh, S Raheem, N Ismail, LY Ling, ... Bioorganic & Medicinal Chemistry Letters 114, 129992 , 2024 2024 Citations: 26
Synthesis, molecular docking and heme detoxification of pyrano [2, 3-c] pyrazole-aminoquinoline hybrids as potential antimalarial agents L Ravindar, KA Bakar, SR Feroz, S Raheem, SA Hasbullah, NI Hassan Sains Malaysiana 53 (8), 1953-1968 , 2024 2024 Citations: 3
Exploring antimalarial potential: Conjugating organometallic moieties with organic fragments for enhanced efficacy NAZ Norazmi, NH Mukhtar, L Ravindar, AS Saaidin, NH Abd Karim, ... Bioorganic Chemistry 149, 107510 , 2024 2024 Citations: 5
Exploring diverse frontiers: advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond L Ravindar, SA Hasbullah, KP Rakesh, S Raheem, HK Agustar, N Ismail, ... European Journal of Medicinal Chemistry 264, 116043 , 2024 2024 Citations: 33
ynthesis, Antimalarial Activity, and Molecular Dynamic Approaches of Salophen Metal Complexes AH Ali, NH Mukhtar, NY Ling, NAZ Norazmi, HK Agustar, LY Ling, ... Sains Malaysiana 53 (8) , 2024 2024
Received: 14 December 2023/Accepted: 14 June 2024 AH ALI, NURH MUKHTAR, N LING, NURAZ NORAZMI, HK AGUSTAR, ... Sains Malaysiana 53 (8), 1901-1912 , 2024 2024
Diserahkan: 14 Disember 2023/Diterima: 14 Jun 2024 Abstrak AH ALI, NURH MUKHTAR, N LING, NURAZ NORAZMI, HK AGUSTAR, ... Sains Malaysiana 53 (8), 1901-1912 , 2024 2024
Triazole hybrid compounds: A new frontier in malaria treatment L Ravindar, SA Hasbullah, KP Rakesh, NI Hassan European journal of medicinal chemistry 259, 115694 , 2023 2023 Citations: 66
Nutritional status as predictors for quality of life among caregivers of children with severe cerebral palsy S Kamal, NH Hamzaid, S Kamaralzaman, S Sharma, NH Jaafar, ... Translational pediatrics 12 (9), 1601 , 2023 2023 Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
Pyrazole and pyrazoline derivatives as antimalarial agents: A key review L Ravindar, SA Hasbullah, KP Rakesh, NI Hassan European Journal of Pharmaceutical Sciences 183, 106365 , 2023 2023 Citations: 126
Triazole hybrid compounds: A new frontier in malaria treatment L Ravindar, SA Hasbullah, KP Rakesh, NI Hassan European journal of medicinal chemistry 259, 115694 , 2023 2023 Citations: 66
Exploring eating and nutritional challenges for children with autism spectrum disorder: Parents’ and special educators’ perceptions NAS Ismail, NS Ramli, NH Hamzaid, NI Hassan Nutrients 12 (9), 2530 , 2020 2020 Citations: 56
The role of 8-amidoquinoline derivatives as fluorescent probes for zinc ion determination NS Mohamad, NH Zakaria, N Daud, LL Tan, GC Ta, LY Heng, NI Hassan Sensors 21 (1), 311 , 2021 2021 Citations: 54
Photo-activated self-healing bio-based polyurethanes CS Wong, NI Hassan, MS Su’ait, MAP Serra, JAM Gonzalez, LA Granda, ... Industrial Crops and Products 140, 111613 , 2019 2019 Citations: 50
Recent developments in antimalarial activities of 4-aminoquinoline derivatives L Ravindar, SA Hasbullah, KP Rakesh, NI Hassan European Journal of Medicinal Chemistry 256, 115458 , 2023 2023 Citations: 49
Synthesis, molecular docking, and antimalarial activity of hybrid 4-aminoquinoline-pyrano [2, 3-c] pyrazole derivatives MA Shamsuddin, AH Ali, NH Zakaria, MF Mohammat, AS Hamzah, ... Pharmaceuticals 14 (11), 1174 , 2021 2021 Citations: 44
Transformation of crystalline starch nanoparticles into highly luminescent carbon nanodots: Toxicity studies and their applications RSA Sonthanasamy, WYW Ahmad, S Fazry, NI Hassan, AM Lazim Carbohydrate polymers 137, 488-496 , 2016 2016 Citations: 38
Orthogonal recognition processes drive the assembly and replication of a [2] rotaxane T Kosikova, NI Hassan, DB Cordes, AMZ Slawin, D Philp Journal of the American Chemical Society 137 (51), 16074-16083 , 2015 2015 Citations: 37
An amperometric biosensor for the determination of bacterial sepsis biomarker, secretory phospholipase group 2-IIA using a tri-enzyme system NN Nik Mansor, TT Leong, E Safitri, D Futra, NS Ahmad, DN Nasuruddin, ... Sensors 18 (3), 686 , 2018 2018 Citations: 34
Exploring diverse frontiers: advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond L Ravindar, SA Hasbullah, KP Rakesh, S Raheem, HK Agustar, N Ismail, ... European Journal of Medicinal Chemistry 264, 116043 , 2024 2024 Citations: 33
Cross‐Coupling of C− H and N− H Bonds: A Hydrogen Evolution Strategy for the Construction of C− N Bonds L Ravindar, SA Hasbullah, NI Hassan, HL Qin European Journal of Organic Chemistry 2022 (31), e202200596 , 2022 2022 Citations: 27
Pyridine and pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development L Ravindar, SA Hasbullah, KP Rakesh, S Raheem, N Ismail, LY Ling, ... Bioorganic & Medicinal Chemistry Letters 114, 129992 , 2024 2024 Citations: 26
Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and PPAR receptors using in vivo and in silico models JSM Chia, AAO Farouk, TAST Mohamad, MR Sulaiman, H Zakaria, ... Molecules 26 (13), 3849 , 2021 2021 Citations: 24
Zinc status in public health: exploring emerging research trends through bibliometric analysis of the historical context from 1978 to 2022 NS Mohamad, LL Tan, NIM Ali, NF Mazlan, EE Sage, NI Hassan, CT Goh Environmental Science and Pollution Research 30 (11), 28422-28445 , 2023 2023 Citations: 23
Molecular docking study of the interactions between Plasmodium falciparum lactate dehydrogenase and 4-aminoquinoline hybrids NH Zakaria, LK Wai, NI Hassan Sains Malaysiana 49 (8), 1905-1913 , 2020 2020 Citations: 23
Low temperature capture of pseudorotaxanes NI Hassan, V del Amo, E Calder, D Philp Organic Letters 13 (3), 458-461 , 2011 2011 Citations: 21
A review of food texture modification among individuals with cerebral palsy: the challenges among cerebral palsy families S Kamal, S Kamaralzaman, S Sharma, NH Jaafar, PM Chern, NI Hassan, ... Nutrients 14 (24), 5241 , 2022 2022 Citations: 20
An electrochemical DNA biosensor for carcinogenicity of anticancer compounds based on competition between methylene blue and oligonucleotides ND Md. Sani, EY Ariffin, W Sheryn, MA Shamsuddin, LY Heng, J Latip, ... Sensors 19 (23), 5111 , 2019 2019 Citations: 20
A new and all-solid-state potentiometric aluminium ion sensor for water analysis KS Ying, LY Heng, NI Hassan, SA Hasbullah Sensors 20 (23), 6898 , 2020 2020 Citations: 18