Oluwole Akinola

@unilorin.edu.ng

Professor, Faculty of Basic Medical Sciences
Dean, Faculty of Basic Medical Sciences
University of Ilorin, Nigeria

Oluwole Akinola


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https://researchid.co/oluwoleakinola
Oluwole B. Akinola is a Professor of Anatomy and the Dean of Basic Medical Sciences. He was the Head of Anatomy and presently PI of the Laboratory of Neuro-endocrinology. Akinola’s Laboratory seeks to understand the link between androgen deprivation, insulin resistance and synaptic plasticity; including understanding how impaired insulin receptor signalling contributes to the pathogenesis and progression of neurodegenerative diseases. His lab also studies the association between heavy metals, obesogenic diets and corticogenesis. Specifically, he studies how gestational co-exposure to these environmental factors impact the migration of GABAergic and glutamatergic neurons during corticogenesis in rodent models, in a bid to understand the developmental mechanisms of certain neurological conditions such as autism spectrum disorders, epilepsy and schizophrenia. Prof. Akinola is the recipient of the IBRO Research Fellowship, UniLecce Pre-doctoral Fellowship and IBRO Return Home Fellowship.

EDUCATION

Postdoctoral Research Fellowship, 2012-2013; Uniformed Services University of the Health Sciences, Bethesda, USA.
Doctor of Philosophy (PhD Anatomy), 2007-2011; University of Ilorin, Nigeria.
Pre-doctoral Research Fellowship, 2007-2008; University of Lecce, Italy.
Master of Science (MSc Anatomy), 1999-2001; University of Lagos, Nigeria.
Bachelor of Science (BSc Anatomy), 1992-1997; University of Ilorin, Nigeria.

RESEARCH, TEACHING, or OTHER INTERESTS

Anatomy, Endocrinology, Structural Biology, Developmental Neuroscience
52

Scopus Publications

1099

Scholar Citations

19

Scholar h-index

39

Scholar i10-index

Scopus Publications

  • Histological and immunohistochemical study of the neuroprotective potentials of trans-cinnamaldehyde in Wistar rat model of insulin resistance
    S. Olorunnado, O. Akinola
    Rwanda Medical Journal, 2024
    INTRODUCTION: The incidence of insulin resistance is on the increase globally. Earlier reports linked impaired insulin signaling and glucose intolerance to cognitive decline, suggesting that improving insulin signaling could enhance neuronal survival. Trans-cinnamaldehyde (TCA) is an active component of cinnamon and has many pharmacological importance. However, the effects of TCA on insulin resistance-induced neurodegenerative changes are unclear. This study, therefore, aimed at evaluating the effects of trans-cinnamaldehyde on hippocampal histoarchitecture in insulin-resistant rats. METHODS: Twenty adult Wistar rats were fed with a high-fat diet for 8 weeks and then injected with a low dose of STZ (30 mg/kg body weight intraperitoneally). 60mg/kg of TCA was orally administered once daily for 4 weeks. Histological and immunohistochemical techniques were used to investigate the ameliorative potentials of TCA on the hippocampus of Wistar Rats. RESULTS: TCA administration to insulin-resistant rats histologically and immunohistochemically reduced pyknosis, astrogliosis, and neurodegenerative changes in the hippocampus when compared with untreated insulin-resistant rats. CONCLUSION: TCA prospect as a novel therapy in insulin-resistant subjects with neurogenerative diseases could be further explored.
  • Curcumin intervention in hippocampal atrophy of diet-induceAlzheimer-like deficits in insulin-resistant rats
    A. A. Mohammed, O. B. Akinola
    Rwanda Medical Journal, 2024
    INTRODUCTION: The primary mechanism connecting Type 2 diabetes mellitus (T2DM) to the neurodegenerative deficits in brain regions such as the hippocampus is insulin resistance. Neurodegenerative deficits in the form of amyloid aggregation and Tau hyperphosphorylation, which are hallmarks of Alzheimer's disease, are documented for both conditions in scientific literature. A mouse model of insulin resistance was used to study this relationship, and curcumin, a flavonoid contained in the spice turmeric, was evaluated as a potential treatment because of its reported benefits in lowering hyperglycemia and hyperlipidemia in diabetes mellitus. Curcumin is a prime contender against these pervasive diseases due to its efficacy, accessibility, affordability, and safety. METHODS: The study methodology included measuring fasting blood glucose levels, staining hippocampal sections for histomorphological examination, and ELISA to quantify hippocampal PI3K expression, AKT expression, and GSK3-β. Data were processed using one-way ANOVA and Turkey's post hoc test. RESULTS: The findings demonstrated that oral curcumin effectively corrected hyperglycemia and reduced insulin resistance. The study further revealed that insulin resistance was related to hippocampal atrophy and related deficits in the assessed rat model. Curcumin ameliorated these changes, reduced the aggregation of Aβ in the hippocampus, and reversed impaired signaling of proteins PI3K, AKT, and GSK-3β. CONCLUSION: The study's findings imply that oral curcumin has potential therapeutic advantages against prevalent neuronal death linked to abnormalities mimicking Alzheimer's disease and insulin resistance. Hence, curcumin may benefit dementia patients who also have insulin resistance.
  • Evaluation of the neuroprotective potential of Trans-cinnamaldehyde in female Wistar rat model of insulin resistance
    Journal of Krishna Institute of Medical Sciences University, 2023
  • The synergistic ameliorative activity of peroxisome proliferator-activated receptor-alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in a rat model of insulin resistance
    Olumayowa K. Idowu, Olushola O. Oluyomi, Oluwatomisin O. Faniyan, Olufunke O. Dosumu, Oluwole B. Akinola
    Ibrain, 2022
    Insulin resistance (IR) is a risk factor for metabolic disorders and neurodegeneration. Peroxisome proliferator‐activated receptor (PPAR) agonists have been proven to mitigate the neuronal pathology associated with IR. However, the synergetic efficacy of these agonists is yet to be fully described. Hence, we aimed to investigate the efficacy of PPARα/γ agonists (fenofibrate and pioglitazone) on a high‐fat diet (HFD) and streptozotocin (STZ)‐induced hippocampal neurodegeneration. Male Wistar rats (200 ± 25 mg/body weight [BW]) were divided into five groups. The experimental groups were fed on an HFD for 12 weeks coupled with 5 days of an STZ injection (30 mg/kg/BW, i.p) to induce IR. Fenofibrate (FEN; 100 mg/kg/BW, orally), pioglitazone (PIO; 20 mg/kg/BW, orally), and their combination were administered for 2 weeks postinduction. Behavioral tests were conducted, and blood was collected to determine insulin sensitivity after treatment. Animals were killed for assessment of oxidative stress, cellular morphology characterization, and astrocytic evaluation. HFD/STZ‐induced IR increased malondialdehyde (MDA) levels and decreased glutathione (GSH) levels. Evidence of cellular alterations and overexpression of astrocytic protein was observed in the hippocampus. By contrast, monotherapy of FEN and PIO increased the GSH level (p < 0.05), decreased the MDA level (p < 0.05), and improved cellular morphology and astrocytic expression. Furthermore, the combined treatment led to improved therapeutic activities compared to monotherapies. In conclusion, FEN and PIO exerted a therapeutic synergistic effect on HFD/STZ‐induced IR in the hippocampus.
  • Structural Changes in the Medial Prefrontal Cortex and Anterior Cingulate Cortex of Dehydroepiandrosterone- Induced Wistar Rat Model of Polycystic Ovarian Syndrome
    Enya Joseph Igbo and
    Basic and Clinical Neuroscience, 2022
    Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder in women that is associated with an increased risk of infertility. This study aims to evaluate the neurobehavioral and neurochemical changes along with the associated changes in the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC) of the dehydroepiandrosterone (DHEA)-induced PCOS model rats. Methods: A total of 12 female juvenile Wistar rats (30 to 50 g) about 22 to 44 days old were divided into 2 groups. The control group received sesame oil while the PCOS group received sesame oil plus DHEA. All treatment was done via daily subcutaneous injection for 21 days. Results: Subcutaneous DHEA-induced PCOS significantly depleted the line crossing and rearing frequency in the open field, along with the percentage of the time in the white box, line crossing, rearing, and peeping frequency in the black and white box, and the percentage of alternation in the Y-maze. PCOS significantly increased the immobility time, freezing period, and the percentage of time in the dark area in the forced swim test, open field test, and black and white box, respectively. The level of luteinizing hormone, follicle-stimulating hormone, malondialdehyde (MDA), reactive oxygen species (ROS), and interleukin-6 (IL-6) increased significantly, while norepinephrine depleted significantly with an obvious decrease in the brain-derived neurotrophic factor level in the PCOS model rats. PCOS rats exhibited cystic follicles in the ovaries and necrotic or degenerative like features in the hippocampal pyramidal cells. Conclusion: DHEA-induced PCOS results in anxiety and depressive behavior with structural alteration in rats, possibly through the elevation of MDA, ROS, and IL-6 levels, which also attributes to impaired emotional and executive functions in the mPFC and ACC.
  • Lasting metabolic effect of a high-fructose diet on global cerebral ischemia
    Oluwatomilayo Patience Ojo, Paula Andrea Perez-Corredor, Johanna Andrea Gutierrez-Vargas, Oluwole Busayo Akinola, Gloria Patricia Cardona-Gómez
    Nutritional Neuroscience, 2022
    Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects of a 20% high fructose diet (HFD) and global cerebral ischemia on neurological, cognitive and emotional performance in three-month-old male Wistar rats. Results: Our results demonstrated that fructose intake led to increases in body weight and blood glucose, as well as reduced insulin sensitivity. The co-morbidity of fructose intake and cerebral ischemia resulted to hyperlipidemia, as well as increases in liver and adipocyte damage, which worsened neurological performance and resulted in alterations in learning and emotional skills at two weeks post-ischemia. No significant biochemical changes in autophagy and plasticity markers at the late stage of ischemia were observed. Conclusion: These results suggested that obesity causes a lasting effect on metabolic disorders that can contribute to increased neurological impairment after cerebral ischemia.
  • Effect of naproxen on testicular morphometry and serum gonadotropin level of cadmium intoxication in rats
    European Journal of Anatomy, 2021
  • Hippocampal cellular changes in androgen deprived insulin resistant rats
    Emmanuel O. Yawson, Oluwole B. Akinola
    Metabolic Brain Disease, 2021
  • Low testicular zinc level, p53 expression and impairment of Sertoli cell phagocytosis of residual bodies in rat subjected to psychological stress
    Leke Jacob Medubi, Oluwole Busayo Akinola, Adeoye Oyetunji Oyewopo
    Andrologia, 2021
    Psychological stress is a known aetiology of infertility. However, the mechanisms translating it to reproductive dysfunction are not fully elucidated. Three experiments were performed on Wistar rats were designed to evaluate Sertoli cell function under stress. In Experiment I, rats were randomised into three groups: saline baseline group given saline, ASEMA baseline group given aqueous extract of Massularia acuminata, zinc baseline group administered zinc orally. In Experiment II, exposure to psychological stress (for 1 hour per day) was layered on Experiment I while Experiment III substituted stress with administration of dexamethasone (DX). Six rats were sacrificed per group per experiment on days 7 and 14 and the right testis was excised and processed for PAS‐haematoxylin staining and the left used for Zn determination. Results show significantly lower testicular Zn level as well more intensely immunoexpression of p53 in saline stress and saline DX groups compared with other groups. Also seen are the presence of residual bodies in the seminiferous tubular lumen of saline groups in Experiments II and III suggesting failure of residual bodies to be transported back towards the basement membrane. This study demonstrates that psychological stress impairs the ability of Sertoli cells to recycle residual bodies.
  • Plasmodium berghei-induced malaria decreases pain sensitivity in mice
    Aboyeji L. Oyewole, Oluwole Akinola, Bamidele V. Owoyele
    Onderstepoort Journal of Veterinary Research, 2021
    Various types of pain were reported by people with Plasmodium falciparum and were mostly attributed to a symptom of malarial infection. Neural processes of pain sensation during malarial infection and their contributions to malaria-related death are poorly understood. Thus, these form the focus of this study. Swiss mice used for this study were randomly divided into two groups. Animals in the first group (Pb-infected group) were inoculated with Plasmodium berghei to induce malaria whilst the other group (intact group) was not infected. Formalin test was used to assess pain sensitivity in both groups and using various antagonists, the possible mechanism for deviation in pain sensitivity was probed. Also, plasma and brain samples collected from animals in both groups were subjected to biochemical and/or histological studies. The results showed that Pb-infected mice exhibited diminished pain-related behaviours to noxious chemical. The observed parasite-induced analgesia appeared to be synergistically mediated via µ-opioid, α2 and 5HT2A receptors. When varied drugs capable of decreasing pain threshold (pro-nociceptive drugs) were used, the survival rate was not significantly different in the Pb-infected mice. This showed little or no contribution of the pain processing system to malaria-related death. Also, using an anti-CD68 antibody, there was no immunopositive cell in the brain to attribute the observed effects to cerebral malaria. Although in the haematoxylin and eosin-stained tissues, there were mild morphological changes in the motor and anterior cingulate cortices. In conclusion, the pain symptom was remarkably decreased in the animal model for malaria, and thus, the model may not be appropriate for investigating malaria-linked pain as reported in humans. This is the first report showing that at a critical point, the malaria parasite caused pain-relieving effects in Swiss mice.
  • Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice
    Michael O. Gabriel, Maria Nikou, Oluwole B. Akinola, Daniela D. Pollak, Spyridon Sideromenos
    Behavioural Brain Research, 2020
  • Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour
    G.O. Omotoso, O.J. Olajide, I.T. Gbadamosi, J.O. Adebayo, B.U. Enaibe, et al.
    Heliyon, 2019
  • Neuroanatomical and molecular correlates of cognitive and behavioural outcomes in hypogonadal males
    O. B. Akinola, M. O. Gabriel
    Metabolic Brain Disease, 2018
  • Comparison of indices of insulin resistance and islet beta-cell dysfunction across rat models of diabetes mellitus induced by modified diets or streptozotocin
    Journal of Krishna Institute of Medical Sciences University, 2018
  • Distribution and Cellular Localization of KCC2 in the Ferret Neocortex
    Francis T. Djankpa, Oluwole B. Akinola, Sharon L. Juliano
    Developmental Neuroscience, 2018
  • Lactational lead exposure perturbates androgenesis in Juvenile and pubertal wistar rats
    Journal of Krishna Institute of Medical Sciences University, 2017
  • Peripheral insulin resistance induced by streptozotocin and modified ddiets: Implications for hippocampal structural and functional iintegrity
    Pakistan Journal of Medical and Health Sciences, 2017
  • Effects of Unripe Musa Paradisiaca on the Histochemistry of the Testis and Testosterone Levels in Adult Albino Rats
    Nigerian Journal of Physiological Sciences Official Publication of the Physiological Society of Nigeria, 2017
  • Sweet old memories: a review of the experimental models of the association between diabetes, senility and dementia
    O. B. Akinola
    Metabolic Brain Disease, 2016
  • Combined effects of chronic hyperglycaemia and oral aluminium intoxication on testicular tissue and some male reproductive parameters in Wistar rats
    O. B. Akinola, S. A. Biliaminu, O. G. Adedeji, B. S. Oluwaseun, O. M. Olawoyin, et al.
    Andrologia, 2016
  • Short Wavelength Cone Opsin Is Not Expressed in the Retina of Arboreal African Pangolin (Manis tricuspis)
    Adejoke J. Adekanmbi, Adefisayo A. Adekanmbi, Oluwole B. Akinola
    Scientifica, 2016
  • Sodium azide-induced degenerative changes in the dorsolateral prefrontal cortex of rats: Attenuating mechanisms of kolaviron
    European Journal of Anatomy, 2016
  • Repeated acute oral exposure to Cannabis sativa impaired neurocognitive behaviours and cortico-hippocampal architectonics in Wistar rats
    Nigerian Journal of Physiological Sciences, 2016
  • Characterization of prefrontal cortex microstructure and antioxidant status in a rat model of neurodegeneration induced by aluminium chloride and multiple low-dose streptozotocin
    Oluwole B. Akinola, Sikiru A. Biliaminu, Rianat A. Adediran, Kehinde A. Adeniye, Fatimah C. Abdulquadir
    Metabolic Brain Disease, 2015
  • PPAR-γ agonist pioglitazone improves semen quality and testicular histomorphometrics with partial reversal of hyperglycaemia in alloxan-induced diabetic rats
    O.B. Akinola, O.O. Dosumu, S.A. Sanusi, T.F. Ajayi, T.H. Olajide
    Middle East Fertility Society Journal, 2015
  • Kolaviron was protective against sodium azide (NaN3) induced oxidative stress in the prefrontal cortex
    Olayemi J. Olajide, Bernard U. Enaibe, Oluwamolakun O. Bankole, Oluwole B. Akinola, Babafemi J. Laoye, et al.
    Metabolic Brain Disease, 2015
  • PPAR γ agonist pioglitazone partially reverses hyperglycemia but improves semen quality and testicular histomorphometrics in alloxan-induced diabetic rats
    O. Akinola, S. Sanusi, T. Ajayi, T. Olajide
    Journal of Morphological Sciences, 2015
  • Histoenzymic evaluation of the frontal cortex of young wistar rats following prenatal nicotine administration
    Rawal Medical Journal, 2015
  • Testicular histomorphometry and semen quality of adult Wistar rats following juvenile oral lead intoxication
    European Journal of Anatomy, 2015
  • In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre
    Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Joseph Oluwatope Adebayo, Ahmed Adebayo Ishola, Ayodele Olufemi Soladoye, et al.
    Journal of Integrative Medicine, 2014
  • Neuromorphometric analysis of the lateralprefrontal cortex of young wistar rats exposed to nicotine in utero
    Rawal Medical Journal, 2014
  • Azathioprine and Methotrexate impaired the morphology and functions of the testes in adult wistar rats
    A. Akinlolu, O. Akinola, P. Khobe, K. Obasi, O. Dada
    Journal of Morphological Sciences, 2014
  • Antimalarial activity of cocos nucifera husk fibre: Further studies
    J. O. Adebayo, E. A. Balogun, S. O. Malomo, A. O. Soladoye, L. A. Olatunji, et al.
    Evidence Based Complementary and Alternative Medicine, 2013
  • Morphological and neurohistological changes in adolescent rats administered with nicotine during intrauterine life
    Nigerian Journal of Physiological Sciences, 2013
  • Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats - The therapeutic potential of virgin coconut oil
    Olufunke O. Dosumu, Oluwole B. Akinola, Edidiong N. Akang
    Middle East Fertility Society Journal, 2012
  • Treatment of alloxan-induced diabetic rats with metformin or glitazones is associated with amelioration of hyperglycaemia and neuroprotection
    Oluwole Akinola
    Open Diabetes Journal, 2012
  • Effects of combined leaf extract of vernonia amygdalitis and azadirachta indica on hepatic morphology and hepatotoxicity markers in streptozotocin-induced diabetic rats
    OB Akinola
    Journal of Chinese Integrative Medicine, 2011
  • Should complementary and alternative medicine familiarisation modules be taught in African medical schools?
    OB Akinola
    Journal of Chinese Integrative Medicine, 2011
  • Ameliorative effects of ethanolic leaf extract of azadirachta indica on renal histologic alterations in streptozotocin-induced diabetic rats
    Akinola Oluwole Busayo, Zatta Laura, Dosumu Olufunke Olubusola, Akinola Oluwafunmike Sharon, Dini Luciana, et al.
    American Journal of Chinese Medicine, 2011
  • Formal body bequest program in Nigerian medical schools: When do we start?
    Oluwole Busayo Akinola
    Anatomical Sciences Education, 2011
  • Diabetes-induced prefrontal Nissl substance deficit and the effects of neem-bitter leaf extract treatment
    Oluwole B Akinola, Olaiya G Omotoso, Olufunke O Dosumu, Oluwafunmike S Akinola, Favour Olotufore
    International Journal of Morphology, 2011
  • Histoenzymic effects of cigarette smoke on the superior colliculus of rattus norvegicus
    G. Omotoso, O. Akinola, E. A. Caxton-martins, R. Kadir, A. Akinyinka
    Internet Journal of Toxicology, 2010
  • Azadirachta indica Leaf Extract Ameliorates Hyperglycemia and Hepatic Glycogenosis in Streptozotocin-Induced Diabetic Wistar Rats
    International Journal of Phytomedicine, 2010
  • Ethanolic leaf extract of Vernonia amygdalina improves islet morphology and upregulates pancreatic G6PDH activity in streptozotocin-induced diabetic Wistar rats
    Pharmacologyonline, 2010
  • Chronic treatment with ethanolic extract of the leaves of Azadirachta indica ameliorates lesions of pancreatic islets in streptozotocin diabetes
    International Journal of Morphology, 2010
  • Vernonia amygdalina upregulates hepatic enzymes and improves liver microanatomy in experimental diabetes mellitus
    Pharmacologyonline, 2009
  • Intestinal lesions of streptozotocin-induced diabetes and the effects of Azadirachta indica treatment
    Pharmacologyonline, 2009
  • Evaluation of the Histo-Gastroprotective and antimicrobial activities of Heliotropium indicum linn (Boraginaceae)
    Malaysian Journal of Medical Sciences, 2008
  • Ethanol extract of the leaves of Psidium guajava Linn enhances sperm output in healthy Wistar rats.
    African Journal of Medicine and Medical Sciences, 2007
  • Spermatoprotective activity of the leaf extract of Psidium guajava Linn.
    Nigerian Postgraduate Medical Journal, 2007
  • Proteinaceous diet inhibits gossypol-induced spermatotoxicity
    European Journal of Histochemistry, 2006
  • Effect of cottonseed oil on oestrous cycle and ovulation in albino rats of Wistar strain.
    Nigerian Postgraduate Medical Journal, 2006

RECENT SCHOLAR PUBLICATIONS

  • Spondias mombin polyphenols Intervention on hypothalamic neuropeptide Ff-1 receptor signalling in dehydroepiandrosterone-induced polycystic ovary syndrome in rat
    JI Enya, OB Akinola
    Neuroscience 580, 14 , 2025
    2025
  • Trans-Cinnamaldehyde Mitigates Neurodegenerative Changes in Wistar Rats Models of Insulin-Resistance
    S Olorunnado, O Akinola
    JOURNAL OF NEUROCHEMISTRY 169 , 2025
    2025
  • Obesogenic diet-induced insulin-resistant rats develop neurobehavioral and memory deficits following bisphenol-A and cadmium co-exposure
    AT Lawal, OB Akinola
    Journal of Health Science Research 10 (1), 18-24 , 2025
    2025
  • Anthropometric Analysis of Craniofacial Indices in Students of Yoruba Lineage
    SB Kareem, OO Eweoya, O Akinola, A Imam, A Ibrahim, TT Arogundade, ...
    The Journal of Anatomical Sciences , 2024
    2024
  • Histological and immunohistochemical study of the neuroprotective potentials of trans-cinnamaldehyde in Wistar rat model of insulin resistance
    S Olorunnado, O Akinola
    Rwanda Medical Journal 81 (1), 140-147 , 2024
    2024
  • Curcumin intervention in hippocampal atrophy of diet-induced Alzheimer-like deficits in insulin-resistant rats
    AA Mohammed, OB Akinola
    Rwanda Medical Journal 81 (1), 103-113 , 2024
    2024
  • HEAD AND NECK
    FA Sulaimon, OB Akinola, BU Enaibe, MS Ajao
    Department of Anatomy, University of Ilorin , 2024
    2024
  • Evaluation of the neuroprotective potential of Trans-Cinnamaldehyde in a rat model of insulin resistance
    S Olorunnado, O Akinola
    IBRO Neuroscience Reports 15, S467-S468 , 2023
    2023
  • Neuromorphological and Biochemical Effects of Co-exposure to Bisphenol A and Cadmium in Insulin-resistant Rats
    AT Lawal, AO Sharafadeen, OB Akinola
    The Journal of Neurobehavioral Sciences 10 (3), 74-81 , 2023
    2023
    Citations: 2
  • Evaluation of the neuroprotective potential of trans-cinnamaldehyde in female Wistar rat model of insulin resistance.
    SE Olorunnado, OP Odum, OB Akinola
    Journal of Krishna Institute of Medical Sciences (JKIMSU) 12 (2) , 2023
    2023
    Citations: 4
  • Structural changes in the medial prefrontal cortex and anterior cingulate cortex of dehydroepiandrosterone-induced wistar rat model of polycystic ovarian syndrome
    EJ Igbo, U Okoliko, I Aminu, A Kopada, S Olorunnado, OB Akinola
    Basic and Clinical Neuroscience 13 (5), 695 , 2022
    2022
    Citations: 9
  • The synergistic ameliorative activity of peroxisome proliferator‐activated receptor‐alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in …
    OK Idowu, OO Oluyomi, OO Faniyan, OO Dosumu, OB Akinola
    ibrain 8 (3), 251-263 , 2022
    2022
    Citations: 13
  • Curcumin ameliorate cortical histomorphological deecits in Streptozocin and western diet induced neurodegeneration in Wistar Rats
    AA Mohammed, OB Akinola
    Res. Sq , 2022
    2022
    Citations: 1
  • The Effects of Flavonoids in Curcumin on Neurobehavioral Deficits in Insulin-resistant Rats
    AA Mohammed, OB Akinola
    The Journal of Neurobehavioral Sciences 9 (2), 51-57 , 2022
    2022
    Citations: 4
  • Hippocampal cellular changes in androgen deprived insulin resistant rats
    EO Yawson, OB Akinola
    Metabolic Brain Disease 36 (5), 1037-1048 , 2021
    2021
    Citations: 7
  • Low testicular zinc level, p53 expression and impairment of sertoli cell phagocytosis of residual bodies in rat subjected to psychological stress
    LJ Medubi, OB Akinola, AO Oyewopo
    Andrologia 53 (3), e13958 , 2021
    2021
    Citations: 4
  • Plasmodium berghei -induced malaria decreases pain sensitivity in mice
    AL Oyewole, O Akinola, BV Owoyele
    Onderstepoort Journal of Veterinary Research 88 (1), 1871 , 2021
    2021
    Citations: 8
  • Effect of naproxen on testicular morphometry and serum gonadotropin level of cadmium intoxication in rats
    OP Odum, OA Adeyanju, TS Olawuyi, AO Soladoye, OB Akinola
    Eur. J. Anat 25, 5 , 2021
    2021
  • Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice
    MO Gabriel, M Nikou, OB Akinola, DD Pollak, S Sideromenos
    Behavioural Brain Research 380, 112419 , 2020
    2020
    Citations: 22
  • Ameliorative Effects of Kolaviron on Behavioural Deficits and Oxidative Damage in Prefrontal Cortex and Hippocampus of Cuprizone-Induced Demyelinated Mice
    GO Omotoso, JO Adebayo, OJ Olajide, IT Gbadamosi, BU Enaibe, ...
    Nigerian Journal of NeuroscienceNig. J. Neurosci 11 (2), 53-61.2020 , 2020
    2020
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Evaluation of the histo-gastroprotective and antimicrobial activities of Heliotropium indicum Linn (Boraginaceae)
    AA Adelaja, MD Ayoola, JO Otulana, OB Akinola, A Olayiwola, ...
    The Malaysian Journal of Medical Sciences: MJMS 15 (3), 22 , 2008
    2008
    Citations: 67
  • Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats–The therapeutic potential of virgin coconut oil
    OO Dosumu, OB Akinola, EN Akang
    Middle East Fertility Society Journal 17 (2), 122-128 , 2012
    2012
    Citations: 61
  • Treatment of alloxan-induced diabetic rats with metformin or glitazones is associated with amelioration of hyperglycaemia and neuroprotection
    O Akinola, M Gabriel, AA Suleiman, F Olorunsogbon
    The Open Diabetes Journal 5 (1), 8-12 , 2012
    2012
    Citations: 58
  • Chronic Treatment with Ethanolic Extract of the Leaves of Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes.
    OB Akinola, EA Caxton-Martins, L Dini
    International Journal of Morphology 28 (1) , 2010
    2010
    Citations: 56
  • Formal body bequest program in Nigerian medical schools: When do we start?
    OB Akinola
    Anatomical sciences education 4 (4), 239-242 , 2011
    2011
    Citations: 49
  • Kolaviron was protective against sodium azide (NaN 3 ) induced oxidative stress in the prefrontal cortex
    OJ Olajide, BU Enaibe, OO Bankole, OB Akinola, BJ Laoye, OM Ogundele
    Metabolic brain disease 31 (1), 25-35 , 2016
    2016
    Citations: 43
  • Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour
    GO Omotoso, OJ Olajide, IT Gbadamosi, JO Adebayo, BU Enaibe, ...
    Heliyon 5 (7) , 2019
    2019
    Citations: 38
  • Beneficial effects of low dose Musa paradisiaca on the semen quality of male Wistar rats
    AS Alabi, GO Omotoso, BU Enaibe, OB Akinola, CNB Tagoe
    Nigerian Medical Journal 54 (2) , 2013
    2013
    Citations: 36
  • Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
    JO Adebayo, EA Balogun, SO Malomo, AO Soladoye, LA Olatunji, ...
    Evidence‐Based Complementary and Alternative Medicine 2013 (1), 742476 , 2013
    2013
    Citations: 34
  • Ethanol extract of the leaves of Psidium guajava Linn enhances sperm output in healthy Wistar rats.
    OB Akinola, OS Oladosu, OO Dosumu
    African journal of medicine and medical sciences 36 (2), 137-140 , 2007
    2007
    Citations: 33
  • Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats
    A Imam, MS Ajao, MI Ajibola, A Amin, WI Abdulmajeed, AZ Lawal, ...
    Bulletin of faculty of pharmacy, cairo university 54 (1), 49-57 , 2016
    2016
    Citations: 30
  • Spermatoprotective activity of the leaf extract of Psidium guajava Linn
    OB Akinola, OS Oladosu, OO Dosumu
    Niger Postgrad Med J 14 (4), 273-276 , 2007
    2007
    Citations: 28
  • Ameliorative Effects of Ethanolic Leaf Extract of Azadirachta indica on Renal Histologic Alterations in Streptozotocin-Induced Diabetic Rats
    A Oluwole Busayo, Z Laura, D Olufunke Olubusola, ...
    The American Journal of Chinese Medicine 39 (05), 903-916 , 2011
    2011
    Citations: 26
  • Neuroanatomical and molecular correlates of cognitive and behavioural outcomes in hypogonadal males
    OB Akinola, MO Gabriel
    Metabolic brain disease 33 (2), 491-505 , 2018
    2018
    Citations: 24
  • Diabetes-induced prefrontal Nissl substance deficit and the effects of neem-bitter leaf extract treatment
    EH de Neem Amargo
    Int. j. morphol 29 (3), 850-856 , 2011
    2011
    Citations: 23
  • Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice
    MO Gabriel, M Nikou, OB Akinola, DD Pollak, S Sideromenos
    Behavioural Brain Research 380, 112419 , 2020
    2020
    Citations: 22
  • Sweet old memories: a review of the experimental models of the association between diabetes, senility and dementia
    OB Akinola
    Metabolic Brain Disease 31 (5), 1003-1010 , 2016
    2016
    Citations: 21
  • PPAR-γ agonist pioglitazone improves semen quality and testicular histomorphometrics with partial reversal of hyperglycaemia in alloxan-induced diabetic rats
    OB Akinola, OO Dosumu, SA Sanusi, TF Ajayi, TH Olajide
    Middle East fertility society journal 20 (4), 271-279 , 2015
    2015
    Citations: 20
  • Supracondylar and infratubercular processes observed in the humeri of Nigerians
    KA Oluyemi, UC Okwuonu, OA Adesanya, OB Akinola, DA Ofusori, ...
    African Journal of Biotechnology 6 (21) , 2007
    2007
    Citations: 20
  • Effects of combined leaf extract of Vernonia amygdalina and Azadirachta indica on hepatic morphology and hepatotoxicity markers in streptozotocin-induced diabetic rats.
    OB Akinola, GO Omotoso, OS Akinola, OO Dosumu, ET Adewoye
    Zhong xi yi jie he xue bao= Journal of Chinese Integrative Medicine 9 (12 … , 2011
    2011
    Citations: 18