wassanm.husein

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physiology
Medical College, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq

wassanm.husein


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https://researchid.co/w203040

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology, Animal Science and Zoology, General Biochemistry, Genetics and Molecular Biology, Biochemistry
9

Scopus Publications

64

Scholar Citations

4

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Evaluation of the Kidney Injury Molecules 1, Cystatin C, and GFR as Predictive Values in Staging and Progression of Renal Disease
    Reproductive Health Eastern Europe, 2026
  • Physiological, molecular, and histological evaluation of the effects of cobalamin on cardiac function in castrated rabbits
    Mohammed Asker, Wassan Husain, Hadeel Khaleel, Mustafa Abdullah
    Open Veterinary Journal, 2026
    Background: Testosterone deficiency is associated with adverse cardiac remodeling, oxidative stress, and inflammation. Aim: To investigate the physiological, biochemical, and histological effects of cobalamin (vitamin B12) supplementation on cardiac physiology in castrated rabbits. Methods: A total of 24 male rabbits were divided into three groups: control (C), castrated (CA), and castrated with cobalamin supplementation (CA + C). Biochemical markers, including cardiac troponin I (cTnI), heart-type fatty acid binding protein (H-FABP), homocysteine, glutathione (GSH), interleukin-3 (IL-3), galectin-3 (Gal-3), translocator protein (TSPO), and thrombospondin-1 (TSP-1), were measured using ELISA. Myocardial tissue was histologically evaluated alongside GAPDH and ANP gene expression analysis using quantitative real-time reverse-transcription PCR (qRT-PCR). Statistical significance was set at p value < 0.05. Results: Castration significantly increased the levels of cardiac markers, such as cTnI, H-FABP, homocysteine, IL-3, and Gal-3, while reducing GSH levels (p<0.001). Cobalamin supplementation significantly restored these biochemical parameters, with notable reductions in cTnI, H-FABP, homocysteine, IL-3, Gal-3, and GSH levels (p<0.01). Histological analysis revealed myocardial contraction failure, fibrosis, and inflammation in castrated rabbits, which were mitigated by cobalamin supplementation. Gene expression analysis showed GAPDH and ANP upregulation in the castrated group, which was partially restored after cobalamin treatment. Additionally, cobalamin supplementation significantly improved the expression of other markers, such as TSPO and TSP-1, its potential to modulate inflammatory and oxidative pathways in the heart. Conclusion: Cobalamin supplementation mitigates the harmful effects of testosterone deficiency on the heart by improving oxidative stress, inflammation, and cardiac remodeling. These findings the potential of this drug for correcting cardiovascular dysfunction associated with hormonal deficiencies.
  • Molecular docking and dynamics of some thiazolidine derivatives using the SARS-CoV-2 main protease as target protein
    Ayat N. Hassan, Mohnad Abdalla, Dawood S. Abid, Ali A. A. Al-Al-Shawi, Wafa Ali Eltayb, Dahlia N Al-Saidi, Farah A. Mohammed, Wassan Mohammed Husain, Ayat J. Kadhum, Ruaa Q. Ibrahim, Noor H. Faisal, Iman N Luaibi
    Journal of Applied Biological Chemistry, 2026
    Ayat N. Hassan ∙ Mohnad Abdalla ∙ Dawood S. Abid ∙ Ali A. A. Al-Al-Shawi ∙ Wafa Ali Eltayb ∙ Dahlia N Al-Saidi ∙ Farah A. Mohammed ∙ Wassan Mohammed Husain ∙ Ayat J. Kadhum ∙ Ruaa Q. Ibrahim ∙ Noor H. Faisal ∙ Iman N Luaibi. JABC 2026;69:98-107. https://doi.org/10.3839/jabc.2026.013
  • Protective effects of allicin against stanozolol-induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model
    Mohammed Hayder Asker, Noor AL‐Huda Salah AL‐Zuhairy, Wassan Mhammed Husain, Mustafa Riyadh Abdullah
    Animal Models and Experimental Medicine, 2025
    BackgroundThere are many forms of anabolic steroids, including stanozolol (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacologica impact of allicin, a natural attribute obtained from garlic, on obstructing cardiac injury in rabbits that received stanozolol.MethodsThirty rabbits were divided into three groups: control, stanozolol‐treated, and stanozolol plus allicin. Cardiac function was assessed by measuring troponin, creatine kinase (CK), Galectin‐3, and GDF‐15. Oxidative stress and antioxidant markers, including malondialdehyde (MDA), glutathione, and catalase, were analyzed. Inflammatory mediators such as C‐reactive protein (CRP), interleukin‐6 (IL‐6), NF‐κB, iNOS, nitric oxide (NO), tumor necrosis factor‐alpha (TNF‐α), and interleukin‐1 beta (IL‐1β) were evaluated. Lipid profile parameters, including total cholesterol, low‐density lipoprotein (LDL), and high‐density lipoprotein (HDL), were measured. Histopathological examination assessed myocardial damage, fibrosis, and collagen deposition.ResultsStanozolol administration significantly increased cardiac damage markers, oxidative stress, and inflammatory mediators while causing dyslipidemia, characterized by elevated LDL and total cholesterol and reduced HDL. Allicin co‐administration effectively countered these effects by reducing oxidative stress and inflammation, restoring antioxidant balance, and improving lipid profiles. Histopathological analysis revealed severe myocardial disorganization, necrosis, and fibrosis in the stanozolol group, whereas the allicin‐treated group exhibited preserved myocardial structure with reduced collagen deposition.ConclusionAllicin significantly mitigates stanozolol‐induced cardiotoxicity by reducing oxidative stress, inflammation, lipid dysregulation, and myocardial damage, as evidenced by biochemical and histopathological findings. These results suggest that allicin may serve as a potential therapeutic agent to counteract the cardiovascular risks associated with anabolic steroid use.
  • Evaluating the Efficacy of Berberine Supplement versus Ozempic® Injection in Modulating Glycemic State, Lipid Metabolism and Body Weight in Streptozotocin-Induced Diabetic Rats
    Wassan Mhammed Husain, Israa J. Mohammad, Dahlia N Al-Saidi
    Advances in Animal and Veterinary Sciences, 2025
  • Association between C-reactive protein levels and viral infection severity
    , Aya R. Abdulwahhab Alheany, Israa J. Mohammad, , Wassan Mhammed Husain, and
    Epitheorese Klinikes Farmakologias Kai Farmakokinetikes, 2025
    Background: C-reactive protein (CRP) is a vital immune response protein produced by the liver in response to inflam-mation, increased CRP values signify the intensity of the inflammatory response in several viral infections. Aim: This study investigates the link between C-reactive protein (CRP) levels and the severity of several viral infections, includ¬ing hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simples 2 virus (HSV-2), and varicella-zoster virus (VZV). Methodology: A cross-sectional study was undertaken from the first of October 2024 to the end of November 2024. A total of fifty patients were diagnosed with a viral infection within the last four weeks. Patients were asked to complete a questionnaire and submit blood samples for investigation of CRP, viral load, and WBC counts. Results: The results revealed that CRP levels differed across patients, with HCV and VZV having higher mean values. There were substantial positive connections between CRP levels and white blood cell count, viral load, and hospitalization rates, indicating that CRP is an important index for inflammation and illness severity. Conclusion: The study emphasizes the clinical significance of CRP in determining illness state and directing treatment methods for viral infections.
  • Ameliorative Effect of Alpha Lipoic Acid on Manganese-Induced Testicular Dysfunction
    Wassan Mhammed Husain, Raghad Raad Hwidyii, Ali Mosa Rashid Al-Yasari
    Pakistan Journal of Zoology, 2025
  • The Effective Role of Phitofert ® Supplement in Male Reproductive Hormones and Epididymal Sperm Quality in Carbon Tetrachloride (CCL4) Treated Rats
    Wassan Mhammed Husain, Zainab Sattar Ali
    Advances in Animal and Veterinary Sciences, 2022
    The goal of this study was to see if Phitofert might help improve sperm function in carbon tetrachloride (CCL4) -treated and healthy adult rats. Twenty-four adult rats were randomly divided into four groups and given the following treatments for 28 days: G1: as a control, the animals were oral administration with DW. G2: healthy rats were given 0.035 mg/kg BW of Phitofert every day by gavage. G3: twice a week, they were given 500 mg/kg B.W. of CCL4 mixed with an equivalent volume of olive oil (o.5 ml/kg B.W.). G4: were treated twice a week with 500 mg/ kg BW of CCL4 mixed with an equivalent amount of olive oil (o.5 ml/kg BW) and gavaged with (0.035 mg/kg BW) of Phitofert daily. In the tenth and twenty-eighth of the experiment, blood samples were taken by heart puncture for serum collection. In comparison to all other groups, the current results reveal a significant (p0. 05) decrease in testosterone, somatic testicular index, and sperm quality in the G3 group, nevertheless, there was a significant (P<0.05) increase in LH, FSH, sperm abnormalities percent, and dead sperm percent in the G3 group. The capacity of Phitofert to restore all passive effects of CCL4 and increase epididymal sperm quality was demonstrated in G4 groups.
  • Effect of different doses from ZnONPS on the pituitary-testes axis function in adult male rats
    Wassan Mhammed Husain, Jawad Kadhim Araak, Orooba Mohammed Saeed Ibrahim
    Advances in Animal and Veterinary Sciences, 2019
    | In our study, ZnONPs was prepared and characterized for investigation of pituitary-testes axis function in adult male rats. Fifty healthy adult male rats selected, weighted 300 ± 50 gm, randomly divided to five group each group have ten animals. One of them group consider as control group and other four group designed as (G1, G2, G3 and G4) group which receive oral dose of ZnONPs in different concentration (5, 10, 20 and 40 mg/kgB.W) respectively for 56 day. Blood samples were collected via cardiac puncture for serum collection in (zero time, 28 and 56 day of experiment). The results showed significant (P<0.05) elevation of testosterone and FSH hormones concentration in G3 and G4 after 56 day of experimental period as a compared with zero time and 28 day of experiment, whereas LH and inhibin B hormones concentration showed a significant (P<0.05) decrement in all group at 56 day as a compared with control group and other period time. Histological study of testes and pituitary gland showed different pathological changes on these two gland’s tissue and cells as mild to severe effects especially at dose (20 and 40 mg/kg B.W). Histometric study of seminiferous tubules illustrated a significant (P<0.05) elevation of seminiferous tubules diameters in G4 group, whereas showed non-significant (P˃0.05) differences in number of interstitial cells in treated groups.

RECENT SCHOLAR PUBLICATIONS

  • Molecular docking and dynamics of some thiazolidine derivatives using the SARS-CoV-2 main protease as target protein
    AN Hassan, M Abdalla, DS Abid, AAA Al-Al-Shawi, WA Eltayb, ...
    J Appl Biol Chem 69 (13), 98-107 , 2026
    2026
  • Physiological, molecular, and histological evaluation of the effects of cobalamin on cardiac function in castrated rabbits
    MH Asker, WM Husain, HK Khaleel, MR Abdullah
    Open Veterinary Journal 16 (2), 1082-1082 , 2026
    2026
  • Association between C-reactive protein levels and viral infection severity
    WMH Aya R. Abdulwahhab Alheany, Israa J. Mohammad2Ken
    EPITHEORESE KLINIKES FARMAKOLOGIAS KAI FARMAKOKINETIKES 43, 37-40 , 2025
    2025
  • An Experimental Evaluation of the Physiological, Molecular, and Histological Effects of Pyridoxine on the Cardiovascular System in Ovariectomized Rabbits
    MH Asker, DS Al-saeed, WM Husain, MR Abdullah
    Authorea 2025 (0809) , 2025
    2025
  • Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model
    MH Asker, NALHS AL‐Zuhairy, WM Husain, MR Abdullah
    Animal Models and Experimental Medicine 8 (7), 1196-1205 , 2025
    2025
    Citations: 2
  • Ameliorative Effect of Alpha Lipoic Acid on Manganese-Induced Testicular Dysfunction
    WMHRRHAMR Al-Yasari3
    Pakistan J. Zool 57 (2), 887-894 , 2025
    2025
  • Evaluating the efficacy of berberine supplement versus ozempic® injection in modulating glycemic state, lipid metabolism and body weight in streptozotocin-induced diabetic rats
    WM Husain, IJ Mohammad, DN Al-Saidi
    Adv. Anim. Vet. Sci 13 (3), 704-711 , 2025
    2025
  • Assessment Of Hematological Parameters In Rabbits Treated With Ivermectin
    NALHSZWMHMMNKI Alzand
    African Journal of Biomedical Research 27 (3), 1926 , 2024
    2024
    Citations: 1
  • The Correlation between Magnesium and HbA1C in type Two Diabetes
    WM Husain, RE Ahmed
    International Journal of Science and Management Studies (IJSMS) 5 (4), 97-82 , 2022
    2022
    Citations: 1
  • The Effective Role of Phitofert ® Supplement in Male Reproductive Hormones and Epididymal Sperm Quality in Carbon Tetrachloride (CCL4) Treated Rats
    ZSA Wassan Mhammed Husain1 *
    Advances in Animal and Veterinary Sciences 10 (2), 292 , 2022
    2022
    Citations: 2
  • The correlation between iron storage marker (ferritin) and glycated hemoglobin in patient with type two diabetes mellitus
    WM Husain, RE Ahmed
    Journal of Genetic and Environment Conservation 10 (2), 158-162 , 2022
    2022
    Citations: 1
  • Metformin's hypolipidemic action in obese rats and its influence on leptin hormone levels
    ZS Ali, WM Husain
    Journal of Genetic and Environment Conservation 10 (1), 67-74 , 2022
    2022
    Citations: 1
  • Study The Role of Nigella Sativa Silver Antiparticles on Some Liver Biomarkers and Hepatocyte Comet Assay in Stressed Rats
    WM Husain
    Annals of R.S.C.B. 25 (6), 2529-2543 , 2021
    2021
    Citations: 1
  • Green Synthesis of Zinc Oxide Nanoparticles from (Punica granatum L) Pomegranate Aqueous Peel Extract
    JKAOMSI Wassan Mhammed Husain
    The Iraqi Journal of Veterinary Medicine 43 (2), 6-14 , 2019
    2019
    Citations: 27
  • Effect of different doses from znonps on the pituitary-testes axis function in adult male rats
    AJK HusainWM, OMS Ibrahim
    Adv. Anim. Vet. Sci 7 (7), 550-556 , 2019
    2019
    Citations: 11
  • Evaluation of Zinc Oxide Nanoparticles Biosynthesized from Pomegranate (Punica granatum L.) Peel Extract on Pituitary – Testes Axis in Adult Male Rats
    WM Husain
    2019
    Citations: 2
  • Effect of zinc oxide nanoparticles on sperm cell comet assay, testis malondialdehyde and glutathione peroxidase levels in adult rats.
    OMSI Wassan M Husain, Jawad K Araak
    Online Journal of Veterinary Research 23 (3), 206-213 , 2019
    2019
    Citations: 6
  • Protective Role of Pomegranate peel extract on the Pituitary gland of adult male rabbits treated with CCL4
    JK Arrack, WM Hussen
    Journal of Kerbala for Agricultural Sciences 4 (5), 83-98 , 2017
    2017
    Citations: 1
  • Protective Role of Pomegranate Peel Extract on Testis in Adult Male Rabbits Treated with Carbon Tetrachloride
    WM Hussen, JK Arrack
    Iraqi J. Vet. Med 38 (1), 74-82 , 2014
    2014
    Citations: 8
  • the protective role of pomegranate peel extract (punica granatum l.) on the pituitary gland and testis function in local adult male rabbits exposed to carbon tetrachloride
    WM Husain
    College of Veterinary Medicine / University of Baghdad in Partial … , 2013
    2013

MOST CITED SCHOLAR PUBLICATIONS

  • Green Synthesis of Zinc Oxide Nanoparticles from (Punica granatum L) Pomegranate Aqueous Peel Extract
    JKAOMSI Wassan Mhammed Husain
    The Iraqi Journal of Veterinary Medicine 43 (2), 6-14 , 2019
    2019
    Citations: 27
  • Effect of different doses from znonps on the pituitary-testes axis function in adult male rats
    AJK HusainWM, OMS Ibrahim
    Adv. Anim. Vet. Sci 7 (7), 550-556 , 2019
    2019
    Citations: 11
  • Protective Role of Pomegranate Peel Extract on Testis in Adult Male Rabbits Treated with Carbon Tetrachloride
    WM Hussen, JK Arrack
    Iraqi J. Vet. Med 38 (1), 74-82 , 2014
    2014
    Citations: 8
  • Effect of zinc oxide nanoparticles on sperm cell comet assay, testis malondialdehyde and glutathione peroxidase levels in adult rats.
    OMSI Wassan M Husain, Jawad K Araak
    Online Journal of Veterinary Research 23 (3), 206-213 , 2019
    2019
    Citations: 6
  • Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model
    MH Asker, NALHS AL‐Zuhairy, WM Husain, MR Abdullah
    Animal Models and Experimental Medicine 8 (7), 1196-1205 , 2025
    2025
    Citations: 2
  • The Effective Role of Phitofert ® Supplement in Male Reproductive Hormones and Epididymal Sperm Quality in Carbon Tetrachloride (CCL4) Treated Rats
    ZSA Wassan Mhammed Husain1 *
    Advances in Animal and Veterinary Sciences 10 (2), 292 , 2022
    2022
    Citations: 2
  • Evaluation of Zinc Oxide Nanoparticles Biosynthesized from Pomegranate (Punica granatum L.) Peel Extract on Pituitary – Testes Axis in Adult Male Rats
    WM Husain
    2019
    Citations: 2
  • Assessment Of Hematological Parameters In Rabbits Treated With Ivermectin
    NALHSZWMHMMNKI Alzand
    African Journal of Biomedical Research 27 (3), 1926 , 2024
    2024
    Citations: 1
  • The Correlation between Magnesium and HbA1C in type Two Diabetes
    WM Husain, RE Ahmed
    International Journal of Science and Management Studies (IJSMS) 5 (4), 97-82 , 2022
    2022
    Citations: 1
  • The correlation between iron storage marker (ferritin) and glycated hemoglobin in patient with type two diabetes mellitus
    WM Husain, RE Ahmed
    Journal of Genetic and Environment Conservation 10 (2), 158-162 , 2022
    2022
    Citations: 1
  • Metformin's hypolipidemic action in obese rats and its influence on leptin hormone levels
    ZS Ali, WM Husain
    Journal of Genetic and Environment Conservation 10 (1), 67-74 , 2022
    2022
    Citations: 1
  • Study The Role of Nigella Sativa Silver Antiparticles on Some Liver Biomarkers and Hepatocyte Comet Assay in Stressed Rats
    WM Husain
    Annals of R.S.C.B. 25 (6), 2529-2543 , 2021
    2021
    Citations: 1
  • Protective Role of Pomegranate peel extract on the Pituitary gland of adult male rabbits treated with CCL4
    JK Arrack, WM Hussen
    Journal of Kerbala for Agricultural Sciences 4 (5), 83-98 , 2017
    2017
    Citations: 1
  • Molecular docking and dynamics of some thiazolidine derivatives using the SARS-CoV-2 main protease as target protein
    AN Hassan, M Abdalla, DS Abid, AAA Al-Al-Shawi, WA Eltayb, ...
    J Appl Biol Chem 69 (13), 98-107 , 2026
    2026
  • Physiological, molecular, and histological evaluation of the effects of cobalamin on cardiac function in castrated rabbits
    MH Asker, WM Husain, HK Khaleel, MR Abdullah
    Open Veterinary Journal 16 (2), 1082-1082 , 2026
    2026
  • Association between C-reactive protein levels and viral infection severity
    WMH Aya R. Abdulwahhab Alheany, Israa J. Mohammad2Ken
    EPITHEORESE KLINIKES FARMAKOLOGIAS KAI FARMAKOKINETIKES 43, 37-40 , 2025
    2025
  • An Experimental Evaluation of the Physiological, Molecular, and Histological Effects of Pyridoxine on the Cardiovascular System in Ovariectomized Rabbits
    MH Asker, DS Al-saeed, WM Husain, MR Abdullah
    Authorea 2025 (0809) , 2025
    2025
  • Ameliorative Effect of Alpha Lipoic Acid on Manganese-Induced Testicular Dysfunction
    WMHRRHAMR Al-Yasari3
    Pakistan J. Zool 57 (2), 887-894 , 2025
    2025
  • Evaluating the efficacy of berberine supplement versus ozempic® injection in modulating glycemic state, lipid metabolism and body weight in streptozotocin-induced diabetic rats
    WM Husain, IJ Mohammad, DN Al-Saidi
    Adv. Anim. Vet. Sci 13 (3), 704-711 , 2025
    2025
  • the protective role of pomegranate peel extract (punica granatum l.) on the pituitary gland and testis function in local adult male rabbits exposed to carbon tetrachloride
    WM Husain
    College of Veterinary Medicine / University of Baghdad in Partial … , 2013
    2013