Metabolites profiling and molecular docking identification of putative leads from endophytic Phyllosticta capitalensis as modulators of key druggable structural targets of rotavirus A Taofeeq Garuba, Rayhaan Govender, Habibah Abdulsalam Isah, Saheed Sabiu Transactions of the Royal Society of South Africa, 2022 Rotavirus-induced gastroenteritis is a global health concern and the leading cause of death in low-income countries and children under the age of five. While rotavirus A (RVA) vaccines are available, there accessibility and efficacy remain challenging, especially in the third world countries. This has necessitated the need to develop therapeutics to manage RVA infection. This study investigated gas chromatography-mass spectrometry-derived Phyllosticta capitalensis metabolites as potential therapeutics against the key structural proteins [VP8* portion of the VP4 (spike protein), the VP7 (capsid protein), and the VP1 (RNA-dependent RNA polymerase)] of RVA using molecular docking and ADME approaches. The results revealed that four [lup-20(29)-en-one, A’-neogammacer-22(29)-ene, stigmasta-4,7,22-trien-3-α-ol, and fucosterol] of the 67 metabolites had favourable affinity for the three structural proteins and belonged to classes of metabolite of antiviral importance. Further analysis and pharmacokinetic profiling showed that the pentacyclic triterpenoids, lup-20(29)-en-one and A’-neogammacer-22(29)-ene, had the potential to be developed as antivirals against RVA infection and effort is underway in this direction.
Molecular Characterization of Potential Crop Pathogens Associated with Weeds as Endophytes in Uniilorin Plantations, Nigeria A. A. Lateef, T. Garuba, K. A. Abdulkareem, B. U. Olayinka, G. S. Olahan, et al. Baghdad Science Journal, 2022 Crop diseases are usually caused by inoculum of pathogens which might exist on alternate hosts or weeds as endophytes. These endophytes, cum pathogens, usually confer some beneficial attributes to these weeds or alternate hosts from protection against herbivores, disease resistance, stress tolerance to secondary metabolites production. This study was therefore carried out to isolate potential crop pathogens which exist as endophytes on weed species in the University of Ilorin plantations. Green asymptomatic leaves were collected from 10 weed species across the plantations, and processed for their endophytic fungi isolation. Isolates were purified into pure cultures and used for molecular identification using the internal transcribed spacer (ITS) region of the ribosomal DNA. Phylogenetic analysis of the fungal sequences using MEGA software revealed 9 fungal genera belonging to 13 species, with species in the genera Curvularia, Epicoccum and Daldinia occurring in more than one weed species, while other genera such as Alternaria, Fusarium, Chaetomium, Macrophomina, Arthrinium and Phomopsis occurred in just one weed species each. Daldinia eschscholtzii was isolated in this study as an endophyte from Loudetia arundinacea for the first time. This plant is very abundant in Nigeria and Africa where it is used majorly for thatching and feeding livestocks. This also represents the first endophytic fungi from the genus Loudetia. Potential relationship between the occurrences of these fungi as endophytes and as pathogens are discussed. These discoveries represent the first large-scale molecular identification and several first reports of endophytes from these weed species. These results also represent the first records of some of these fungi in Nigeria.
Nature of hematopoietic system alteration and organ damage induced by fungal filtrate of Pestalotiopsis microspora in vivo Garuba Taofeeq, Lateef Adebola Azeez, Atunwa Soliu Abiola, Lateef Abibat Yetunde, Kolawole Olajumoke Oluwabunmi, et al. Journal of Applied Pharmaceutical Science, 2021 Taofeeq Garuba1, Adebola Azeez Lateef1, Soliu Abiola Atunwa2, Abibat Yetunde Lateef1, Olajumoke Oluwabunmi Kolawole1, Saheed Sabiu3* 1Department of Plant Biology, University of Ilorin, Ilorin, Nigeria. 2Department of Pharmacology and Toxicology, University of Ilorin, Ilorin, Nigeria. 3Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa.
An appraisal of the metabolites, pharmacological and biotechnological significance of edible mushrooms Tolulope Bolaniran, Abdullahi Temitope Jamiu, Taofeeq Garuba, Alhassan Muhammad Wudil, Henry Ademola Adeola, et al. Transactions of the Royal Society of South Africa, 2021 Mushrooms are universally valued for their dietary and therapeutic significance. Their importance could be attributed to numerous nutritive and dietary substances including polysaccharides, terpenoids, phenolics and other light molecular bioactive compounds. These compounds offer optimal health benefits and have been identified as a potential source of nutritional and medicinal products against several debilitating and food-related disorders. Here, we present an updated synopsis of the medicinal attributes of mushrooms, while also highlighting the technological advancements in their cultivation that have led to the birth of engineered species with improved traits that could alleviate malnourishment and contribute towards food security, offer health benefits, and provide efficient ways of waste management.
Comparative biodiversity assessment of weed species in monocropping plantations of University of Ilorin, Nigeria West African Journal of Applied Ecology, 2020
An Efficient Preservation Method for Sweet Orange (Citrus Sinensis) Fruits in Nigeria MK Garba, WB Yahya, MA Adeleke, T Garuba Applied Fruit Science 68 (2), 89 , 2026 2026
Antimicrobial Potential of Algae and Their Metabolites T Garuba Algae and Algal Metabolites: Emerging Applications, Trends and Prospects, 1-26 , 2026 2026
Plants of Healing: The lasting impact of Arab contributions to herbal medicine T Garuba, UI Kankawi, A Abdulbaki, SB Adeyemi, BO Yusuf, S Sabiu Ethnobotany Research and Applications 31, 1-24 , 2025 2025
Nutritional Quality and Fungal Contamination of Tiger Nuts (Cyperus esculentus L.) T Garuba, FA Oluwadare, IO Dosumu, JA Abidoye, BT Sule, TJ Ishola FUOYE Journal of Pure and Applied Sciences (FJPAS) 10 (2), 39-52 , 2025 2025
A Snapshot of the Occurrence and Biological Effects of Mycotoxins T Garuba, BA Owolabi, JN Ohanaka, S Sabiu Passer Journal of Basic and Applied Sciences, e216539 , 2025 2025 Citations: 1
Unveiling the therapeutic significance of shikimate pathway-derived phenolic acids against penicillin-binding protein 3 of Pseudomonas aeruginosa Y Dweba, CE Aruwa, T Garuba, S Sabiu Egyptian Journal of Basic and Applied Sciences 11 (1), 685-706 , 2024 2024
New records of fungal endophytes from Unilorin Sugarcane plantation using internal transcribed spacer gene sequences AA Lateef, T Garuba, KA Abdulkareem, BU Olayinka, GS Olahan, ... Science World Journal 19 (4), 945-950 , 2024 2024
Molecular Identification of Dominant Microbes in Kola nut (Cola nitida) T Garuba, FA Ajala, GS Olahan, AA Lateef BADEGGI JOURNAL OF AGRICULTURAL RESEARCH AND ENVIRONMENT 6 (1), 13-24 , 2024 2024 Citations: 1
Assessment of postharvest handling of banana fruits and associated fungi in Ganmo market, Kwara State, Nigeria T Garuba, B Atolagbe, RA Yusuff, BY Lawal, TJ Ishola 2024 Citations: 2
ANTI-TOXIC PRINCIPLES FROM MUSA SAPIENTUM AND MORINGA OLEIFERA AMELIORATED SKIN HISTO-PATHOLOGY, DECREASED LIPID PEROXIDATION AND PROMOTED MELATONIN/TNF-ALPHA/P53-MEDIATED … A Akinlolu, MO Ameen, AO Oyewopo, RE Kadir, P Nwogu, M Saad, ... Malaysian Journal of Pharmaceutical Sciences 22 (1), 43-59 , 2024 2024
18 Food scanners: applications in the food industry S Saheed, P Charlene, G Taofeeq, N Mamosa Food Science and Technology: Fundamentals and Innovation, 445 , 2023 2023 Citations: 4
Antitoxic Principles from Moringa oleifera (Mo11) and Musa sapientum (Ms06) Ameliorated Cadmium Chloride-Induced Renal Hyperplasia and Apoptosis through Ki67/P53-Mediated … A Akinlolu, M Ameen, G Ebito, N Asogwa, R Akindele, B Fagbohunka, ... CHRISMED Journal of Health and Research 10 (2), 136-141 , 2023 2023
Haematological, serum biochemical and histopathological changes in acute and sub-chronic aqueous extract of oyster mushroom in male Wistar rats T Garuba, IT Olabanji, OM Awogboro, GS Olahan, SA Atunwa, OA Ahmed, ... Journal of Scientific Research 15 (1), 201-213 , 2023 2023 Citations: 4
Effects of Different Carbon and Nitrogen Sources on the Biomass of Molecularly Identified Fungi Associated with Fruit Rot of Tomato T Garuba, OT Mustapha, GP Oyeyiola Journal of the University of Ruhuna 10 (1) , 2022 2022 Citations: 2
Metabolites profiling and molecular docking identification of putative leads from endophytic Phyllosticta capitalensis as modulators of key druggable structural … T Garuba, R Govender, HA Isah, S Sabiu Transactions of the Royal Society of South Africa 77 (3), 207-217 , 2022 2022 Citations: 7
Structural And Phytochemical Characterization of Bioactive Components of the Endophytic Fungi (Trichoderma Harzianum) Extracts OM Ameen, T Garuba, MF Zubair, MT Baker, BZ Arowolo, AO Yakubu Journal of Applied Sciences and Environmental Management 26 (4), 689-693 , 2022 2022 Citations: 2
Microbial load and molecular characterization of fungi associated with sweet pepper (Capsicum annuum L.) during storage T Garuba, BY Lawal, AA Lateef, GS Olahan Romanian Journal of Biology-Plant Biology 67 (1-2), 7-18 , 2022 2022 Citations: 1
Effects of storage conditions and packaging materials on the fruit quality of sweet pepper (Capsicum annuum L.) T Garuba, BY Lawal, OA Abiodun, SA Oyeyinka Science World Journal 17 (4), 542-548 , 2022 2022 Citations: 5
Molecular Characterization of Potential Crop Pathogens Associated with Weeds as Endophytes in Uniilorin Plantations, Nigeria AA Lateef, T Garuba, KA Abdulkareem, BU Olayinka, GS Olahan, ... Baghdad Science Journal 19 (6), 3 , 2022 2022 Citations: 2
PHYTOCHEMICAL SCREENING, ANTI-OXIDANT AND ACTIVITIES OF FRACTIONATED ETHANOLIC EXTRACT OF Moringa Oleifera LEAVE OM Ameen, AA Akinolu, T Garuba, GE Ebito, BZ Arowolo, EO Oyebanji Journal of Chemical Society of Nigeria 46 (6) , 2021 2021
MOST CITED SCHOLAR PUBLICATIONS
Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata S Sabiu, T Garuba, T Sunmonu, E Ajani, A Sulyman, I Nurain, A Balogun Toxicology reports 2, 261-267 , 2015 2015 Citations: 238
Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata S Sabiu, T Garuba, TO Sunmonu, AHO Sulyman, NO Ismail Pharmaceutical biology 54 (1), 180-186 , 2016 2016 Citations: 73
Isolation and identification of fungi involved in the post-harvest spoilage of guava (Psidium guajava) in Awka metropolis JE Amadi, P Nwaokike, GS Olahan, T Garuba Int. J. Eng 4 (10), 7-12 , 2014 2014 Citations: 64
Effects of fungal filtrates on seed germination and leaf anatomy of maize seedlings (Zea mays L., Poaceae) T Garuba, AA AbdulRahaman, GS Olahan, KA Abdulkareem, JE Amadi Journal of Applied Science & Environmental Management 18 (4), 662 , 2014 2014 Citations: 41
Proximate Composition and Chemical Profiles of Reishi Mushroom ( Ganoderma lucidum (Curt: Fr.) Karst) T Garuba, GS Olahan, AA Lateef, RO Alaya, M Awolowo, A Sulyman Journal of Scientific Research 12 (1), 103-110 , 2020 2020 Citations: 39
Shelf life and proximate composition of tomato (Solanum lycopersicum L.) fruits as influenced by storage methods T Garuba, OT Mustapha, GP Oyeyiola Ceylon Journal of Science 47 (4) , 2018 2018 Citations: 34
Influence of substrates on the nutritional quality of Pleurotus pulmonarius and Pleurotus ostreatus T Garuba, KA Abdukkareem, IA Ibrahim, OI Oyebamiji, OA Shoyooye, ... Ceylon Journal of Science 46 (1) , 2017 2017 Citations: 30
Combined administration of Spondias mombin and Ficus exasperata leaf extracts stall Indomethacin-mediated gastric mucosal onslaught in rats. S Saheed, SA Olarewaju, G Taofeeq, ST Olatunde, AA Alanamu African journal of traditional, complementary and alternative medicines 12 … , 2015 2015 Citations: 22
Aeropalynological investigation of the University of Ilorin, Ilorin, Nigeria AA Abdulrahaman, OS Aruofor, T Garuba, OS Kolawole, GS Olahan, ... Journal of Applied Science & Environmental Management 19 (1), 53 , 2015 2015 Citations: 14
Flour functionality, physicochemical and sensory properties of steamed and baked maize meal enriched with defatted soybean SA Oyeyinka, AI Adebayo, AT Oyeyinka, AO Akeem, T Garuba, ... Journal of Food Processing and Preservation 44 (4), e14389 , 2020 2020 Citations: 12
Rhizosphere and non-rhizosphere soil mycoflora of Corchorus olitorius (Jute) GS Olahan, IO Sule, T Garuba, YA Salawu Science World Journal 11 (3), 23-26 , 2016 2016 Citations: 12
Effect of plant extracts on sporulation and spore germination of stored melon seed fungi JE Amadi, EE Adeleke, G Olahan, T Garuba INTERNATIONAL JOURNAL of RESEARCH–GRANTHAALAYAH , 2014 2014 Citations: 12
An appraisal of the metabolites, pharmacological and biotechnological significance of edible mushrooms T Bolaniran, AT Jamiu, T Garuba, AM Wudil, HA Adeola, S Sabiu Transactions of the Royal Society of South Africa 76 (3), 257-272 , 2021 2021 Citations: 9
Isolation and molecular identification of dominant fungal endophytes from green leaves of physic nut (Jatropha curcas) from unilorin plantation, Ilorin, Nigeria AA Lateef, T Garuba, G Sa’ad, M Olesin, GG Eperetun, BB Tiamiyu Sri Lankan Journal of Biology 4 (1) , 2019 2019 Citations: 9
Germination of several groundnut cultivars in relation to incidence of fungi O Ahmed, BU Olayinka, T Garuba, J Ahmed, EO Etejere Science World Journal 12 (1), 38-41 , 2017 2017 Citations: 9
Indomethacin-induced gastric ulceration in rats: protective roles of Spondias mombin and Ficus exasperata. Toxicol Rep 2: 261–267 S Sabiu, T Garuba, T Sunmonu, A Emmanuel, S Abdulhakeem, N Ismaila, ... 2015 Citations: 8
Metabolites profiling and molecular docking identification of putative leads from endophytic Phyllosticta capitalensis as modulators of key druggable structural … T Garuba, R Govender, HA Isah, S Sabiu Transactions of the Royal Society of South Africa 77 (3), 207-217 , 2022 2022 Citations: 7
A Study on Endophytic Fungi, Proximate and Chemical Compositions of a Local Variety of Mango Fruit (Mangifera indica L.) T Garuba, BU Olayinka, KA Abdulkareem, MO Bello, AA Hamid, ... Journal of the University of Ruhuna 6 (2) , 2018 2018 Citations: 7
Membrane stabilization and probable mechanisms of hypoglycemic activity of fruit extract of Solanum incanum L. (Solanaceae) S Sabiu, EO Ajani, RA Aladodo, T Garuba, MO Agunbiade, AA Alimi, ... Comparative Clinical Pathology 27 (6), 1611-1619 , 2018 2018 Citations: 7
Comparative biodiversity assessment of weed species in monocropping plantations of University of Ilorin, Nigeria UB Olayinka, SB Adeyemi, KA Abdulkareem, GS Olahan, AA Lateef, ... West African Journal of Applied Ecology 28 (2), 86-105 , 2020 2020 Citations: 6
