Real-world data of PARP inhibitors in first-line maintenance for BRCA-mutated or HRD-positive advanced ovarian cancer: a multicentre retrospective study from India Susheel Kumar Yeshala, Soumya Surath Panda, Lalatendu Moharana, SV Saju, Krishnakumar Rathinam, Susan Honey Raju, Amit Sehrawat, Deepak Sundriyal, Ashwin Oommen Phillip, Pamela Alice Kinsely, Kanu Priya Bhatia, Smita Kayal, Biswajit Dubashi, Sunu Lazar Cyriac, Sathya Natarajan, Lipsita Samantaray, Swati Sucharita Mohanty, Sudam Sadangi, Snehasis Pradhan, Arti Rana, Prasanth Ganesan Journal of Ovarian Research, 2026 BACKGROUND: Poly (ADP-ribose) polymerase inhibitors (PARPi) have emerged as a significant advancement in the maintenance treatment of advanced High-Grade Serous Ovarian Cancer (HGSOC), particularly in patients with BRCA mutations or Homologous Recombination Deficiency (HRD). While randomized trials have demonstrated their efficacy, real-world evidence from low- and middle-income countries (LMIC) like India remains scarce. This retrospective observational multicentre study aimed to assess the safety and effectiveness of first-line maintenance therapy with Olaparib or Rucaparib in Indian patients with BRCA-mutated (BRCAmut) or HRD-positive (HRD+) advanced HGSOC. RESULTS: The study evaluated data from 46 patients treated between May 2019 and December 2022 across six oncology centres under the BIRAC-supported Network of Oncology Clinical Trials of India. The median age was 50.5 years, with all having HGS histopathology. Stage III disease was present in 32(69.6%), and 12(26.1%) had a family history of cancer. Median turnaround time for gBRCA and HRD investigation was 18 and 20.5 days, respectively. BRCA1mut were seen in 30(65.2%), BRCA2 in 5(10.9%), and non-BRCA HRD + in 11(23.9%). Olaparib was given to 27(58.7%) and Rucaparib to 19(41.3%). At a median follow-up of 22.5 months (range 18–53), the median PFS was not reached. The 12 and 18-month PFS rates were 97.8% and 86.9%, respectively. No significant difference in mPFS was found between the two drugs or between BRCAmut and BRCA-wild HRD+ patients (NR vs. 29 months, p = 0.219) groups. Dose reductions were made in 18(39.1%) of patients due to toxicity [N = 9(50%)] or cost [N = 9(50%)], with no observed impact on PFS between the standard dose and the reduced dose. The major prevalent grade ≥ 3 toxicities comprised anaemia (13%), fatigue (6.5%), and thrombocytopenia (2.2%). CONCLUSION: Despite limitations of a retrospective design, this study supports the clinical efficacy and tolerability of PARPi in LMIC, with efficacy and toxicity outcomes comparable to global trial data. There were no statistically significant differences observed between Olaparib and Rucaparib, standard and reduced doses, or BRCAmut and HRD+ patients. This study supports the feasibility of incorporating PARPi into frontline maintenance therapy for advanced HGSOC in resource-limited environments.
Primary Platinum-Resistant Ovarian Cancer: Clinicopathologic Correlates and Outcomes From a Multicenter Prospective Indian Registry Amit Sehrawat, Lakhwinder Singh, Deepak Sundriyal, Shalini Rajaram, Sathya Natarajan, Aradhana Kumari, Soumya Surath Panda, Sunu Lazar Cyriac, Krishnakumar Rathnam, Ashwin Oommen Philips, Lalatendu Moharana, Lipsita Samantaray, Saju SV, Susheel Kumar Yeshala, Nishant Batta, Ashok Singh, Veena P, Latha Chaturvedula, Jayalakshmi D, Sunitha VC, Pradeep S, Pampa Ch Toi, Prasanth Ganesan JCO Global Oncology, 2026 PURPOSE To identify clinicopathologic factors associated with primary platinum-resistant ovarian cancer and evaluate survival outcomes using data from a multicenter, prospectively maintained Indian cancer registry. MATERIALS AND METHODS Data were analyzed from a prospective database of Network of Oncology Clinical Trials in India registry from six tertiary care centers between January 2022 and December 2023. Primary platinum-resistant ovarian cancer was defined as progression during treatment or recurrence within 6 months of completing initial platinum-based chemotherapy. Demographic, clinical, and treatment variables along with survival outcomes were evaluated. RESULTS Among 367 women with newly diagnosed epithelial ovarian cancer treated with platinum-based chemotherapy, 62 (16.9%) had primary platinum-resistant ovarian cancer. The cohort had a mean age of 54 ± 11.2 years, 79% were postmenopausal, and 53.2% had Eastern Cooperative Oncology Group performance score ≥2. High-grade serous carcinoma histology predominated (75.8%), 90.3% presented with stage III to IV disease, 74.2% had ascites, and 79.1% had peritoneal spread. Debulking surgery was performed in 24.2%, platinum-taxane doublet was used in 83.9%, and among those receiving curative intent treatment, 88.1% received chemotherapy in the neoadjuvant setting. Maintenance therapy was received by 6.5%; none entered clinical trials. Over a median follow-up of 10.32 months, median progression-free and overall survival were 4.75 (95% CI, 4 to 6) and 9.33 (95% CI, 6.2 to 16.3) months, respectively, from baseline at diagnosis. Primary platinum resistance was associated with poor performance status, ascites, advanced stage, omission of debulking surgery, neoadjuvant chemotherapy, and palliative-intent chemotherapy ( P < .05). CONCLUSION Primary platinum resistance affected 16.9% of Indian women with epithelial ovarian cancer and was linked to poor performance status, advanced stage, omission of debulking surgery, neoadjuvant chemotherapy, and dismal survival outcomes underscoring the urgent need for better predictive and therapeutic strategies.
Real-World Experiences of Next-Generation Sequencing in Oncology: From an Indian Multicenter Registry and Collaborative Centers Ashwin Oommen Philips, Soumya Surath Panda, Sunu Cyriac, Lalatendu Moharana, Sindhu Kilaru, et al. Indian Journal of Medical and Paediatric Oncology, 2026 Abstract The integration of next-generation sequencing (NGS) in guiding personalized therapy for oncology faces the challenges, primarily, of cost and drug accessibility. Limited data from Indian academic centers accentuate the need for comprehensive insights into the real-world applications of NGS in oncology. The Network of Oncology Clinical Trials in India (NOCI), accessible at www.noci-india.com, compiled data on patients who underwent NGS for solid organ cancers from January 1, 2018, to December 31, 2021. This study aimed to elucidate the testing indications, sample types analyzed, and the resultant impact on patient care. Analysis of data from six centers included 278 subjects, with 24 specimens (9%) excluded due to quality test failure. Tissue constituted 59.7% of specimens, blood 38.5%, and both 1.8%. Predominantly, NGS was employed for identifying BRCA1/2 mutations (56%) and for targeted therapy in non-small-cell lung cancer (NSCLC; 28%). Only 41 (16%) patients with other cancers underwent multigene NGS panels in pursuit of targetable mutations. Among them, 13 exhibited targetable mutations, and 3 received treatment based on NGS findings. This study underscores that the majority of NGS applications focused on screening for BRCA1/2 mutations and identifying targetable mutations in NSCLC. However, among those undergoing NGS for advanced cancers, only a limited number received personalized therapy. The findings underscore the challenges of utilizing NGS in off-label indications within resource-constrained settings.
Refining early detection of hepatocellular carcinoma: The promise of the GALAD score Harsha S P, Amit Sehrawat, Anusha Mruthyunjaya Swamy, Deepak Sundriyal World Journal of Gastroenterology, 2026 This letter discusses the original article by Villa et al , published in the World Journal of Gastroenterology . Our primary focus is on the GALAD score, its components, standardization, and population-specific variations. We also attempted to discuss the current applications of GALAD score and how combining it with imaging modalities like ultrasound could improve it. Hepatocellular carcinoma (HCC) is still one of the leading causes of cancer death, and early detection is crucial to its prognosis. Current surveillance methods, like alpha-fetoprotein (AFP) and ultrasound, are not very specific, especially when it comes to metabolic-associated steatotic liver disease. Gender, age, AFP, AFP-L3, and des-gamma-carboxy prothrombin are all included in the operator-independent, non-invasive GALAD score, which has become a promising biomarker-based diagnostic tool for HCC. Population-specific cut-points with high sensitivity and specificity have been proposed by multicenter studies like Villa et al , particularly for differentiating between HCC and cirrhosis and healthy controls. However, there is no universal threshold due to variation across etiology, population, and assay technology. GALAD must be a context-sensitive auxiliary in the clinical setting, guiding surveillance intervals and imaging choices while improving predictive performance through serial measurement. Early detection is further improved by integration with imaging modalities, such as the GALADUS score. Standardized biomarker techniques and prospective, multi-ethnic validation are required for broad clinical use and optimal HCC surveillance.
Revisiting the use of steroids in oncology Sai Prasath, S. P. Harsha, Anusha Mruthyunjaya Swamy, Karthik Jayalingappa, Mayank Kapoor, Deepak Sundriyal, Amit Sehrawat, Uttam Kumar Nath Medical Oncology, 2026
Real-World Data on Treatment Outcome of ALK-Positive Non-Small Cell Lung Cancer from an Indian Multicentric Cancer Registry Lalatendu Moharana, Soumya Surath Panda, Suma Devaraj, Ghanashyam Biswas, Ganesh Chandra Subudhi, Prasant Kumar Parida, Sourav Kumar Mishra, Jogamaya Pattnaik, Sambit Mohanty, Sukanya Karunanidhi, Sandhya Lakshmi Singuluri, S. V. Saju, Krishna Kumar Rathnam, Amit Sehrawat, Shikha Mudgal, Sunu Lazar Cyriac, Ashwin Philips, Anil Kumar Jose, Prasant Ganesan South Asian Journal of Cancer, 2024
Impact of COVID-19 Pandemic on Oncology Practices During Nationwide Lockdown Period: A Single Centre Experience and the Way Forward Journal of the Association of Physicians of India, 2020
Neoadjuvant Docetaxel, Cisplatin, and Capecitabine in Borderline-Inoperable Locally Advanced Oral Cavity Squamous Cell Carcinoma: A Prospective Observational Study A Singh, M Malhotra, A Sehrawat, M Priya, A Bhardwaj, XJ Antony, ... European Journal of Surgical Oncology, 111860 , 2026 2026
27eP Real-world efficacy and safety of trastuzumab emtansine (T-DM1 Biosimilar, Ujvira) in early and metastatic HER2-positive breast cancer: A multicentre pooled retrospective … SS Panda, A Mahajan, L Moharana, L Samantaray, M Chandrakanth, ... ESMO Open 11 , 2026 2026
Refining early detection of hepatocellular carcinoma: The promise of the GALAD score HS Prakash, A Sehrawat, AM Swamy, D Sundriyal World Journal of Gastroenterology 32 (7) , 2026 2026
Predictive Patient Characteristics for Chemotherapy-Induced Nausea and Vomiting in Solid Organ Cancers: An Observational Study from a Tertiary Care Setting M Kapoor, D Sundriyal, Y Bahurupi, S Gupta, A Sehrawat 2026
Real-world data of PARP inhibitors in first-line maintenance for BRCA-mutated or HRD-positive advanced ovarian cancer: a multicentre retrospective study from India SK Yeshala, SS Panda, L Moharana, SV Saju, K Rathinam, SH Raju, ... Journal of Ovarian Research , 2026 2026 Citations: 1
Addressing the Challenges of Ewing Sarcoma in Resource-Limited Settings: Analysis of Patient Demographics, Treatment Approaches, and Outcomes in a Tertiary Care Center in LMIC M Kapoor, P Pal, A Sehrawat, D Sundriyal Indian Journal of Medical and Paediatric Oncology 47 (01), A034 , 2026 2026
Multi-Institutional Study on Breast Cancer Among Adolescent and Young Adults in NOCI Affiliated Centers Across India M Manikandan, SV Saju, A Philips, KK Rathnam, B Dubashi, P Ganesan, ... Indian Journal of Medical and Paediatric Oncology 47 (01), A055 , 2026 2026
Comprehensive Clinicopathological and Treatment Analysis of Lung Cancer Patients: Insights from the AIIMS Rishikesh Prospective Cancer Registry A Sehrawat, M Anusha, M Chaudhary, S Natarajan, R Kumar, U Chauhan, ... Indian Journal of Medical and Paediatric Oncology 47 (01), A008 , 2026 2026
Lung Cancer in Adolescent and Young Adults: Unveiling Challenges and Outcomes—A Report from the Network of Oncology Clinical Trials India A Philips, A Sehrawat, KK Rathnam, SV Saju, H Raju, D Sundriyal, ... Indian Journal of Medical and Paediatric Oncology 47 (01), A029 , 2026 2026
Surgico-pathological parameters, treatment patterns, and oncological outcomes in uterine cancer: A real-world insight from a sub-himalayan region of india. K Khoiwal, S Bose, N Chowdhury, A Singh, S Rajaram, A Gaurav, ... International Journal of Gynecological Cancer 36 (2) , 2026 2026
Revisiting the use of steroids in oncology S Prasath, SP Harsha, AM Swamy, K Jayalingappa, M Kapoor, ... Medical Oncology 43 (2), 97 , 2026 2026 Citations: 1
Phase II Open-Label Randomised Controlled Trial Comparing Oxaliplatin and Cisplatin Based Concurrent Chemoradiotherapy in Locally Advanced Head and Neck Cancers Y Yanthan, L Pandey, A Pandey, R Pasricha, D Joseph, S Gupta, ... Clinical Oncology 50, 104005 , 2026 2026 Citations: 1
A Patient with Adenocarcinoma Stomach on FLOT (5-Fluorouracil/Leucovorin, Oxaliplatin, and Docetaxel) Chemotherapy Presents with Tooth Discoloration: Spot the Diagnosis M Kapoor, D Sundriyal, A Sehrawat Indian Journal of Medical and Paediatric Oncology 47 (01), 070-071 , 2026 2026
Epidemiology, Treatment Patterns, and Survival Outcomes in Patients With Uterine Cancer in a Real-World Setting in India S Bose, K Khoiwal, S Rajaram, A Gaurav, R Mundhra, A Bahadur, ... Indian Journal of Surgical Oncology, 1-10 , 2026 2026
856P Translation and validation of the ‘Strength, ambulation, rising from a chair, stair climbing and history of falling’(SARC-F) questionnaire into Hindi language among Indian … A Sehrawat, A Rana, V Kumar, M Pathania, D Sundriyal Annals of Oncology 36, S2064-S2065 , 2025 2025
127P Study of the profile of HER2-positive metastatic breast cancer patients receiving T-DM1 biosimilar, in a real-world setting A Mahajan, SS Panda, L Moharana, L Samantaray, MV Chandrakanth, ... Annals of Oncology 36, S1808 , 2025 2025
Association between insulin resistance biomarkers and metastatic prognosis in treatment-naïve colorectal cancer patients: a pilot study MP Narayanan, A Sehrawat, B Goyal, P Kumar, S Bansal, S Gupta, ... BMC cancer 25 (1), 1-11 , 2025 2025
Unexpected thrombocytopenia of a rare tamoxifen-induced complication in breast cancer therapy: A case report AM Swamy, A Sehrawat, D Sundriyal World Journal of Clinical Cases 13 (31), 109772 , 2025 2025
Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial … K Ronanki, B Shah, P Dalton, A Gupta, P Satadeve, R Benson, ... Blood 146, 1687 , 2025 2025
ASSESSING QUALITY OF LIFE IN INDIAN WOMEN UNDERGOING TREATMENT FOR GYNECOLOGIC CANCERS: A PROSPECTIVE OBSERVATIONAL STUDY S Rajaram, S Nagar, L Singh, L Chawla, A Bahadur, A Gaurav, ... International Journal of Gynecological Cancer 35 (11) , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Neoadjuvant trastuzumab deruxtecan alone or followed by paclitaxel, trastuzumab, and pertuzumab for high-risk HER2-positive early breast cancer (DESTINY-Breast11): a randomised … N Harbeck, S Modi, L Pusztai, S Ohno, J Wu, SB Kim, A Yoshida, A Fabi, ... Annals of Oncology , 2025 2025 Citations: 66
An open-label, noninferiority phase III RCT of weekly versus three weekly cisplatin and radical radiotherapy in locally advanced head and neck squamous cell carcinoma (ConCERT … A Sharma, M Kumar, S Bhasker, A Thakar, R Pramanik, A Biswas, ... Journal of Clinical Oncology 40 (16_suppl), 6004-6004 , 2022 2022 Citations: 65
Gut colonization with carbapenem-resistant enterobacteriaceae adversely impacts the outcome in patients with hematological malignancies: results of a prospective surveillance study SR Jaiswal, S Gupta, RS Kumar, A Sehrawat, A Rajoreya, SK Dash, ... Mediterranean journal of hematology and infectious diseases 10 (1) , 2018 2018 Citations: 64
T cell costimulation blockade for hyperacute steroid refractory graft versus-host disease in children undergoing haploidentical transplantation SR Jaiswal, S Zaman, A Chakrabarti, A Sehrawat, S Bansal, M Gupta, ... Transplant immunology 39, 46-51 , 2016 2016 Citations: 23
Totally Implantable Venous Access Device (Chemoport) in Oncology: Study of 168 Polyurethane Chemoport Catheter System SA Mittal G. S, Sundriyal D, Naik N. B South Asian Journal of Cancer 10 (4), 261-264 , 2021 2021 Citations: 16
Demographic and clinicopathological profile of gall bladder cancer patients: Study from a tertiary care center of the sub-himalayan region in indo-gangetic belt A Gupta, S Gupta, R Anjum, T Siddeek, JJ Chennatt, T Singla, D Rajput, ... Journal of Carcinogenesis 20 (1), 6 , 2021 2021 Citations: 15
Identification of factors influencing delayed presentation of cancer patients G Sharma, S Gupta, A Gupta, VC Kalyani, KK Rohilla, AT Sreejeev, ... International Journal of Community Medicine and Public Health 7 (5), 1-6 , 2020 2020 Citations: 14
Febrile neutropenia due to COVID-19 in an immunocompetent patient YM Devi, A Sehrawat, PK Panda, UK Nath BMJ Case Reports 14 (4), e242683 , 2021 2021 Citations: 10
Bone marrow metastases from solid organ cancer in adults L Arya, D Sundriyal, R Bhandari, R Srivastava, A Sehrawat Indian Journal of Surgical Oncology 12 (3), 545-548 , 2021 2021 Citations: 9
Tripe palms and Malignant Acanthosis Nigricans: More than a diagnostic pointer P Kumar, M Mukundan, A Sehrawat, D Sundriyal Cancer Reports 2020 (October), e1307 , 2020 2020 Citations: 9
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic SAGHRGCNCD Collaborative BMJ Global Health 7 (10), e008797 , 2022 2022 Citations: 8
Embracing geriatric assessment into the treatment plan: The earlier the better D Sundriyal, A Sehrawat Cancer Research, Statistics, and Treatment 5 (4), 717-718 , 2022 2022 Citations: 8
Lung cancer screening: An unending tale DR Poonia, A Sehrawat, MK Gupta Journal of cancer research and therapeutics 17 (6), 1289-1293 , 2021 2021 Citations: 8
Clinicopathologic Profile and Treatment Outcomes of Colorectal Cancer in Young Adults: A Multicenter Study From India JCO global oncology. 10 (01), e2300225 , 2024 2024 Citations: 7
An Institution‑Based Demographic Study of Urinary Bladder Cancer from North India P Kumar, D Sharma, S: Sundriyal, SC Navria, A Sehrawat Indian Journal of Surgical Oncology 13 (Online), NA , 2022 2022 Citations: 7
Impact of Nada Yoga music therapy on anxiety and quality of life in ovarian cancer patients: a randomized controlled trial S Malik, A Sehrawat, J Chaturvedi, R Kumari, SL Barnwal, S Kalra, ... International journal of yoga 17 (2), 138-145 , 2024 2024 Citations: 6
Impact of COVID-19 Pandemic on Oncology Practices During Nationwide Lockdown Period: A Single Centre Experience and the Way Forward D Sundriyal, A Sehrawat, P Kumar, . Bhandari, Rekha Journal of The Association of Physicians of India 68 (July 2020), 43-45 , 2020 2020 Citations: 5
Effects of chemotherapy on fertility and fertility preservation strategies for the women of childbearing potential undergoing chemotherapy: A comprehensive review M Kapoor, AM Swamy, D Sundriyal, M Khanna, N Sinha, S Rajaram, ... Indian Journal of Surgical Oncology 16 (2), 401-407 , 2025 2025 Citations: 4
A synthetic bioactive peptide of the C-terminal fragment of adhesion protein Fibulin7 attenuates the inflammatory functions of innate immune cells in LPS-induced systemic … S Gupta, N Dalpati, SK Rai, A Sehrawat, V Pai, PP Sarangi Inflammation Research 73 (8), 1333-1348 , 2024 2024 Citations: 4
Chemotherapy in geriatric patients with poor performance status small cell lung cancer: Series from a tertiary care center D Sundriyal, P Kumar, U Kumar, A Sehrawat Aging Medicine, 1-4 , 2022 2022 Citations: 4