Prof Ambali obtained the DVM, and M.Sc., and Ph.D. degrees in Veterinary Toxicology from the Ahmadu Bello University in 1992, 2004, and 2009, respectively. He is currently a Professor of Environmental Toxicology and the Deputy Vice-Chancellor, Management Services, and a member of the Governing Council of the University of Ilorin. He had served both Universities at the Departmental, Faculty, and University levels. He was the Head of the Department of Veterinary Physiology and Pharmacology, Sub-Dean, and Dean of the Faculty of Veterinary Medicine from 2012-2017. He was Chairman of the Technical Sub-committee of the Appointments and Promotions Committees from 2018-2020. He is a member and fellow of various academic, professional, and cultural organizations. With an h-index of 26 with over 130 articles in peer review journals and books, Prof. Ambali has attended many local and international conferences. He is married and blessed with children.
EDUCATION
Doctor of Veterinary Medicine - Ahmadu Bello University, Zaria, Nigeria
M.Sc. Veterinary Toxicology, Ahmadu Bello University, Zaria, Nigeria
Ph.D. Veterinary Toxicology, Ahmadu Bello University, Zaria, Nigeria
RESEARCH, TEACHING, or OTHER INTERESTS
Toxicology, Veterinary, Pharmacology, Toxicology and Pharmaceutics, Neuroscience
Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin’s mitigating effect Muftau Shittu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, Mohammed Umaru Kawu, Motunrayo Ganiyat Akande, et al. Toxicology and Industrial Health, 2023 The ability of melatonin to reduce growth inadequacy induced by parental and nutritional combination administration to chlorpyriphos (Ch) and cypermethrin (Cy) was examined in male albino rats. Oral alimentation was given to gravid dams divided into six groups ( n = 10; age: 12 weeks) from the first day of pregnancy to the 21st postnatal day. Distilled water (DW), Soya oil (SYO), and melatonin (MeL) groups were exposed to 2 mL/kg, 2 mL/kg, and 0.5 mg/kg, respectively; the Ch+Cy group was co-exposed to Ch (1.9 mg/kg of LD50) and Cy (7.5 mg/kg of LD50); the MChCy group was preconditioned with MeL (0.5 mg/kg), followed by co-exposure to Ch and Cy; and the ChCyM group was exposed to Ch and Cy and post treated with MeL. Male offspring rats were tested for ontogeny criteria at various points after accouchement. MeL pre- and post-administration reduced the variation in litter size and weight, number of live/dead pups, anogenital distance , crown-rump length, the timing of eye and ear openings, and testicular descent caused by fetal and nutritional co-administration to Ch+Cy in offspring male albino rats. MeL demonstrated preventive promise as a result of its apparent antioxidative capability.
Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Akeem Olayiwola Ahmed, et al. Iranian Journal of Toxicology, 2023 Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats. Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels. Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities. Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.
Hyperglycemia induced by subchronic co-administration of chlorpyrifos and lead in wistar rats: Role of pancreatic lipoperoxidation and alleviating effect of vitamin C Biology and Medicine, 2011
Chlorpyrifos-induced clinical, hematological and biochemical changes in Swiss albino mice- mitigating effect by co-administration of vitamins C and E Life Science Journal, 2010
Co-administration of vitamins C and E ameliorates chronic chlorpyrifos-induced erythrocyte osmotic fragility in wistar rats Australian Journal of Basic and Applied Sciences, 2010
Effect of fermented and unfermented seed extracts of Carica papaya on pre-implantation embryo development in female Wistar rats (Rattus norvegicus) Scientific Research and Essays, 2009
Effect of fermented seed extract of Carica papaya on litters of female wistar rats (Rattus norvegicus) African Journal of Biotechnology, 2009
Hepato-renal toxicity of mercury bioaccumulation in cage-free chickens ( Gallus gallus domesticus ) from gold-producing areas of Zamfara State, Nigeria Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Environmental Sciences Europe 37 (1), 179 , 2025 2025 Citations: 2
African Journal of Biochemistry Research AJ Njouendou, N Nkimih, P Takamo, NF Tanih, BF Bonjoh, SM Eko, ... Assessment , 2025 2025
Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes AO Olatunji, RO Alegbe, SF Ambali, M Shittu, GJ Akorede, A Aremu, ... Phytomedicine Plus 5 (1), 100699 , 2025 2025 Citations: 2
Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male … AO Olatunji, JO Ayo, MM Suleiman, SF Ambali, M Shittu, GJ Akorede, ... Naunyn-Schmiedeberg's Archives of Pharmacology 397 (11), 9181-9190 , 2024 2024 Citations: 1
Evaluating the Supplementary Effects of Vitamin C on Carbamazepine and Pentylenetetrazol-Induced Seizures and Preimplantation Loss in Pregnant Wistar Rats: Implications for … AG Jimoh, AS Folorunsho, A Olatunbosun, OA OMOBOLANLE, ... Asia Pacific J. Med. Toxicol 13 (2) , 2024 2024 Citations: 3
MODULATORY EFFECT OF ASCORBIC ACID ON HEART RATE RESPONSES OF DONKEYS TO PACKING DURING THE HARMATTAN SEASON F OLAIFA, JO AYO, SF AMBALI, PI REKWOT NIGERIAN JOURNAL OF ANIMAL PRODUCTION, 144-147 , 2024 2024
INFLUENCE OF SEASON ON SERUM PROFILES OF SOME NUTRITIONAL METABOLITES DURING THE OESTRUS CYCLE IN SAVANNAH BROWN GOATS MU KAWU, CAM LAKPINI, JO AYO, MY FATIHU, LS YAQUB, B HABIBU, ... NIGERIAN JOURNAL OF ANIMAL PRODUCTION, 124-127 , 2024 2024
Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin’s mitigating effect M Shittu, SF Ambali, JO Ayo, MU Kawu, MG Akande, Z Abdulmalik Toxicology and Industrial Health 39 (7), 398-405 , 2023 2023 Citations: 2
Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats. GJ Akorede, SF Ambali, AO Olatunji, A Aremu, AO Ahmed, A Basiru, ... Iranian Journal of Toxicology 17 (2) , 2023 2023 Citations: 5
Elevated blood mercury and haematological response in free ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State Nigeria Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Environmental Chemistry and Ecotoxicology 5, 39-44 , 2023 2023 Citations: 6
Assessment of blood mercury, immune response, heat shock and oxidative stress marker in free-ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State … Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Journal of Hazardous Materials Advances 8, 100176 , 2022 2022 Citations: 9
Effect of daflon-500 ® , a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats AO Olatunji, JO Ayo, MM Suleiman, SF Ambali, M Shittu, GJ Akorede, ... Toxicological research 38 (3), 345-353 , 2022 2022 Citations: 8
Prolongation of survival duration by extract and fraction of Commiphora africana in mice injected with LD 99 of Naja nigricollis crude venom. HI Isa, A Saleh, M Shittu, MM Suleiman, SF Ambali Savannah Veterinary Journal 5 (2) , 2022 2022 Citations: 1
Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats GJ Akorede, SF Ambali, AO Olatunji, A Aremu, A Basiru, AO Ahmed, ... Pharmacological Research-Modern Chinese Medicine 2, 100055 , 2022 2022 Citations: 4
Melatonin Ameliorates Developmental Landmarks Induced by Gestational and Lactational Coexposure to Chlorpyriphos and Cypermethrin in F1 Male Rats M Shittu, S Ambali, J Ayo, U Kawu, M Akande 2021 Citations: 1
Melatonin mitigates thyroid dysfunction induced by gestational and lactational exposure to mixture of chlorpyriphos and cypermethrin in male Wistar rats M Shittu, SF Ambali, JO Ayo, MU Kawu, AO Olatunji Comparative Clinical Pathology 30 (3), 529-540 , 2021 2021 Citations: 7
Hibiscus sabdariffa Linn extract possesses potential to ameliorate chlorpyriphos-induced haemotoxicity in rats. M Shittu, IT Oyedepo, IH Isa, SF Yahya, SF Ambali, LS Yaqub, AO Olatunji 2021
Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract GJ Akorede, SF Ambali, MG Hudu, MM Suleiman, KY Suleiman, ... Comparative Clinical Pathology 29 (6), 1179-1187 , 2020 2020 Citations: 11
Surveillance for avian influenza virus in captive wild birds and indigenous chickens in Nigeria OB Daodu, HO Jegede, JO Aiyedun, OO Oludairo, ID Olorunshola, ... Tropical animal health and production 52 (5), 2387-2393 , 2020 2020 Citations: 9
Effect of zinc supplementation on chronic hepatorenal toxicity following oral exposure to glyphosate-based herbicide (Bushfire®) in rats EV Tizhe, NDG Ibrahim, MY Fatihu, SF Ambali, IO Igbokwe, UD Tizhe Journal of International Medical Research 48 (8), 0300060520925343 , 2020 2020 Citations: 16
MOST CITED SCHOLAR PUBLICATIONS
Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C S Ambali, D Akanbi, N Igbokwe, M Shittu, M Kawu, J Ayo The Journal of Toxicological Sciences 32 (2), 111-120 , 2007 2007 Citations: 180
Ethnomedical importance of Citrus aurantifolia (christm) swingle OS Enejoh, IO Ogunyemi, MS Bala, IS Oruene, MM Suleiman, SF Ambali The Pharma Innovation 4 (8, Part A), 1 , 2015 2015 Citations: 142
Chlorpyrifos-induced alteration of hematological parameters in Wistar rats: ameliorative effect of zinc. SF Ambali, AT Abubakar, M Shittu, LS Yaqub, SB Anafi, A Abdullahi 2010 Citations: 109
The organophosphate, chlorpyrifos, oxidative stress and the role of some antioxidants: a review C Uchendu, SF Ambali, JO Ayo African Journal of Agricultural Research , 2012 2012 Citations: 108
Hemotoxicity induced by chronic chlorpyrifos exposure in Wistar rats: mitigating effect of vitamin C SF Ambali, JO Ayo, KAN Esievo, SA Ojo Veterinary medicine international 2011 (1), 945439 , 2011 2011 Citations: 88
Ameliorative effects of vitamin C on short-term sensorimotor and cognitive changes induced by acute chlorpyrifos exposure in Wistar rats SF Ambali, SB Idris, C Onukak, M Shittu, JO Ayo Toxicology and Industrial Health 26 (9), 547-558 , 2010 2010 Citations: 70
Chronic chlorpyrifos-induced oxidative changes in the testes and pituitary gland of wistar rats: Ameliorative effects of vitamin C M Shittu, JO Ayo, SF Ambali, MY Fatihu, BI Onyeanusi, MU Kawu Pesticide biochemistry and physiology 102 (1), 79-85 , 2012 2012 Citations: 69
Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate EV Tizhe, NDG Ibrahim, MY Fatihu, II Onyebuchi, BDJ George, SF Ambali, ... Comparative clinical pathology 23 (5), 1535-1543 , 2014 2014 Citations: 61
Ameliorative effect of vitamin C on chronic chlorpyrifos-induced erythrocyte osmotic fragility in Wistar rats SF Ambali, JO Ayo, SA Ojo, KAN Esievo Human & experimental toxicology 30 (1), 19-24 , 2011 2011 Citations: 59
Vitamin E protects Wistar rats from chlorpyrifos-induced increase in erythrocyte osmotic fragility SF Ambali, JO Ayo, SA Ojo, KAN Esievo Food and chemical toxicology 48 (12), 3477-3480 , 2010 2010 Citations: 58
Ameliorative effect of vitamins C and E on neurotoxicological, hematological and biochemical changes induced by chronic chlorpyrifos in Wistar rats SF Ambali Unpublished PhD Dissertation. Zaria, Nigeria: Ahmadu Bello University , 2009 2009 Citations: 52
Cytotoxicity of chlopyrifos and cypermethrin: The ameliorative effects of antioxidants SB Idris, SF Ambali, JO Ayo African Journal of Biotechnology 11 (99), 16461-16467 , 2012 2012 Citations: 51
Subchronic chlorpyrifos-induced clinical, hematological and biochemical changes in Swiss albino mice: protective effect of vitamin E SF Ambali, DO Akanbi, OO Oladipo, LS Yaqub, MU Kawu Int J Biol Med Res. 2 (2), 497-503 , 2011 2011 Citations: 50
Erythrocyte osmotic fragility and lipid peroxidation following chronic co-exposure of rats to chlorpyrifos and deltamethrin, and the beneficial effect of alpha-lipoic acid C Uchendu, SF Ambali, JO Ayo, KAN Esievo, AJ Umosen Toxicology reports 1, 373-378 , 2014 2014 Citations: 48
Chronic co-exposure to chlorpyrifos and deltamethrin pesticides induces alterations in serum lipids and oxidative stress in Wistar rats: mitigating role of alpha-lipoic acid C Uchendu, SF Ambali, JO Ayo, KAN Esievo Environmental Science and Pollution Research 25 (20), 19605-19611 , 2018 2018 Citations: 47
Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats AJ Umosen, SF Ambali, JO Ayo, B Mohammed, C Uchendu Asian Pacific Journal of Tropical Biomedicine 2 (8), 645-650 , 2012 2012 Citations: 46
Chlorpyrifos-induced clinical, haematological and biochemical changes in Swiss albino mice: mitigating effect by co-administration of vitamins C and E SF Ambali, DO Akanbi, M Shittu, A Giwa, OO Oladipo, JO Ayo Life Science Journal 7 (3), 37-44 , 2010 2010 Citations: 46
Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats GJ Akorede, SF Ambali, MG Hudu, AO Olatunji, M Shittu, A Aremu, ... Toxicology reports 7, 269-276 , 2020 2020 Citations: 45
Evaluation of hepatorenal impairments in Wistar rats coexposed to low-dose lead, cadmium and manganese: insights into oxidative stress mechanism OO Oladipo, JO Ayo, SF Ambali, B Mohammed Toxicology mechanisms and methods 26 (9), 674-684 , 2016 2016 Citations: 44
Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc EV Tizhe, NDG Ibrahim, MY Fatihu, IO Igbokwe, BDJ George, SF Ambali, ... Comparative Clinical Pathology 23 (4), 1043-1050 , 2014 2014 Citations: 43