Likai Tan

Scopus Publications

Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription
Dan Huang, Xiaoting Zhang, Xiansong Wang, Ziheng Huang, Judeng Zeng, Xiaodong Liu, Likai Tan, Lin Zhang, Zhenxing Guo, Tony Gin, Jun Yu, Kwok M. Ho, Matthew Tak Vai Chan, Huarong Chen, William Ka Kei Wu
Oncogene, 2026
24-Nor-ursodeoxycholic acid: a novel treatment targeting T-cell-mediated immune dysregulation in primary sclerosing cholangitis and beyond
Likai Tan, William Ka Kei Wu
Gut, 2025
Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem
Wei Hu, Ze Min Chen, Ying Wang, Chao Yang, Zi Ying Wu, Li Juan You, Zhi Yong Zhai, Zhao Yu Huang, Ping Zhou, Si Lin Huang, Xia Xi Li, Gen Hua Yang, Chong Ju Bao, Xiao Bing Cui, Gui Li Xia, Mei Ping Ou Yang, Lin Zhang, William Ka Kei Wu, Long Fei Li, Li Kai Tan, Yu Xuan Zhang, Wei Gong
Nature Communications, 2025
Helicobacter pylori (H. pylori) manipulates the host immune system to establish a persistent colonization, posing a serious threat to human health, but the mechanisms remain poorly understood. Here we integrate single-cell RNA sequencing and TCR profiling for analyzing 187,192 cells from 11 H. pylori-negative and 12 H. pylori-positive individuals to describe the human gastric ecosystem reprogrammed by H. pylori infection, as manifested by impaired antigen presentation and phagocytosis function. We further delineate a monocyte-to-C1QC+ macrophage differentiation trajectory driven by H. pylori infection, while T cell responses exhibit broad functional impairment and hyporesponsiveness with restricted clonal expansion capacity. We also identify an HLA-DRs- and CTLA4-expressing T cell population residing in H. pylori-inhabited stomach that potentially contribute to immune evasion. Together, our findings provide single-cell resolution information into the immunosuppressive microenvironment shaped by H. pylori infection, offering critical insights for developing novel therapeutic approaches to eliminate this globally prevalent pathogen. Helicobacter pylori (H. pylori) establishes chronic infection in human, but the underlying mechanistic insights are lacking. Here the authors use single cell RNA and TCR sequencing to profile peripheral blood and mucosal cells from infected patients to report alterations in macrophage differentiation and T cell gene signature that may contribute to persisting H. pylori infection.
Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation
Zheng Song, Evgeny Klyuchnikov, Anita Badbaran, Likai Tan, Regine J. Dress, Emilia Czajkowski, Simeon Weßler, Radwan Massoud, Christine Wolschke, Anja Schimrock, Yu Zhang, Cedric Ly, Nico Gagelmann, Kristin Rathje, Boris Fehse, Stefan Bonn, Sarina Ravens, Nicola Gagliani, Christian F. Krebs, Ulf Panzer, Francis Ayuk, Nicolaus Kröger, Immo Prinz
Biomarker Research, 2025
Background Alloreactive T cells mediate graft-versus-leukemia (GvL) reactions and acute graft-versus-host disease (aGvHD) in AML patients following allogeneic hematopoietic stem cell transplantation. Methods To investigate biomarkers that identify alloreactive T cells associated with either beneficial GvL or detrimental aGvHD, we collected graft samples and two post-transplant follow-up blood samples (day 30 and day 100) of ten AML patients undergoing hematopoietic stem cell transplantation and profiled over 777,000 CD45 + leukocytes in total by combinatorial barcoding-based mega-scale single-cell RNA sequencing. Results Using immune receptor sequences as intrinsic clonal barcodes, we observed that especially CD8 + graft-derived T cells persisted and displayed enhanced proliferation, clonal expansion, and likely alloreactivity. Notably, patient-derived peripheral leukocytes that survived the conditioning, as identified by sex-chromosome-related genes, were primarily CD4 + T helper cells. MDGA1 expression on T cells and NK cells emerged as a novel biomarker potentially associated with aGvHD. Additionally, we observed a significant deficiency of ADGRG1 expression, a marker of alloreactive cytotoxic T cells, by αβ and γδ T cells from relapsed patients. Conclusions In conclusion, mega-scale single-cell monitoring of graft and hematopoietic immune cell reconstitution allowed us to demonstrate that MDGA1 and ADGRG1 may function as complementary biomarkers expressed by distinct circulating T cells that are associated with divergent outcomes in AML patients, enabling precise risk stratification of alloHSCT outcomes and presenting potential therapeutic targets. Graphical Abstract
Erratum: Correction: Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations (Cancer research (2025) 85 15 DOI: 10.1158/0008-5472.CAN-24-2225.)
Ziheng Huang, Lin Zhang, Huarong Chen, Xiaodong Liu, Likai Tan, Dan Huang, Yingzhi Liu, Yushan Wang, Xinyi Zhang, Alfred Sze Lok Cheng, Maggie Haitian Wang, Wei Kang, Ka-Fai To, Jun Yu, Ho Ko, Le Yu, Sunny H. Wong, Tony Gin, Matthew Tak Vai Chan, Xiansong Wang, William Ka Kei Wu
Cancer Research, 2025
Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Ziheng Huang, Lin Zhang, Huarong Chen, Xiaodong Liu, Likai Tan, Dan Huang, Yingzhi Liu, Yushan Wang, Xinyi Zhang, Alfred Sze Lok Cheng, Maggie Haitian Wang, Wei Kang, Ka-Fai To, Jun Yu, Ho Ko, Le Yu, Sunny H. Wong, Tony Gin, Matthew Tak Vai Chan, Xiansong Wang, William Ka Kei Wu
Cancer Research, 2025
Segmental duplications (SD) are blocks of genomic DNA with high sequence homology that are hotspots for chromosomal rearrangements, coinciding with copy-number and single-nucleotide variations in the population. SDs could represent unstable genomic regions that are susceptible to somatic alterations in human cancers. In this study, we aimed to elucidate the genomic locations of SDs in relation to cancer-related genes and their propensity for somatic alterations in cancer. The analysis showed that tumor suppressor genes (TSG) were less associated with SDs compared with noncancer genes in nearly all mammalian species. TSGs with SDs were larger in size in humans but only modestly conserved among mammals. In humans, the proportion of noncancer genes with SDs decreased as the gene age increased. However, for TSGs, a loss of association with SDs was apparent among young genes. Pan-cancer analysis revealed that TSGs with SDs were more prone to deletions and structural variations independently of gene size. Reanalysis of publicly available experimental data further revealed that genes with SDs tended to replicate late and were more likely to undergo the error-prone mitotic DNA synthesis upon replication stress. In conclusion, the loss of SDs from TSGs during mammalian evolution protects against tumor formation by reducing somatic alterations. Significance: Tumor suppressor genes with segmental duplications have an increased risk for somatic alterations, including deletions and structural variations, in human cancers, identifying them as a genetic Achilles’ heel in tumor suppression.
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice
Yidan Zou, Idy Hiu Ting Ho, Yanjun Jiang, Zhongqi Li, Qingtian Luo, Lhotse Hei Lui Ng, Tingting Jin, Qian Li, Fenfen Qin, Likai Tan, Tony Gin, Ho Ko, Lin Zhang, Huarong Chen, Matthew Tak Vai Chan, Changyu Jiang, William Ka Kei Wu, Xiaodong Liu
Science Translational Medicine, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain–associated neural circuits remains unclear. To investigate this question, we used pharmacological, optogenetic, and genetic manipulations combined with behavioral tests, confocal imaging, and patch-clamp studies in a murine spared nerve injury (SNI) model of neuropathic pain. We demonstrate that spinal microglia pruned inhibitory presynaptic terminals in SNI mice, contributing to the disinhibition of spinal protein kinase C γ (PKCγ) interneurons and facilitating neurotransmission from low-threshold Aβ fibers. Single-cell RNA sequencing revealed that SNI-associated microglial subpopulations exhibited high expression of liver X receptor, apolipoprotein E ( Apoe ), and complement C1q. Global knockout of Apoe , microglia-specific knockdown of Apoe , or treatment with anti-C1q monoclonal antibody reversed SNI-induced pruning of spinal inhibitory synapses, prevented the disinhibition of PKCγ interneurons, and reduced pain hypersensitivity. Our study suggests that destabilization of neural networks through microglia-mediated pruning of inhibitory synapses in the spinal cord contributes to the development of neuropathic pain in mice.
Roseburia intestinalis-derived butyrate alleviates neuropathic pain
Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Lin Zhang, Huarong Chen, Tony Gin, Matthew Tak Vai Chan, William Ka Kei Wu, Lizu Xiao, Xiaodong Liu
Cell Host and Microbe, 2025
Approximately 20% of patients with shingles develop postherpetic neuralgia (PHN). We investigated the role of gut microbiota in shingle- and PHN-related pain. Patients with shingles or PHN exhibited significant alterations in their gut microbiota with microbial markers predicting PHN development among patients with shingles. Functionally, fecal microbiota transplantation from patients with PHN to mice heightened pain sensitivity. Administration of Roseburia intestinalis, a bacterium both depleted in patients with shingles and PHN, alleviated peripheral nerve injury-induced pain in mice. R. intestinalis enhanced vagal neurotransmission to the nucleus tractus solitarius (NTS) to suppress the central amygdala (CeA), a brain region involved in pain perception. R. intestinalis-generated butyrate activated vagal neurons through the receptor, G protein-coupled receptor 41 (GPR41). Vagal knockout of Gpr41 abolished the effects of R. intestinalis on the NTS-CeA circuit and reduced pain behaviors. Overall, we established a microbiota-based model for PHN risk assessment and identified R. intestinalis as a potential pain-alleviating probiotic.
Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain
Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, Lin Zhang, Tony Gin, William K.K. Wu, Matthew T.V. Chan, Changyu Jiang, Xiaodong Liu
Neurotherapeutics, 2025
<h2>Abstract</h2> Chemotherapy-induced peripheral neuropathy (CIPN) and its related pain are common challenges for patients receiving oxaliplatin chemotherapy. Oxaliplatin accumulation in dorsal root ganglion (DRGs) is known to impair gene transcription by epigenetic dysregulation. We hypothesized that sodium butyrate, a pro-resolution short-chain fatty acid, inhibited histone acetylation in DRGs and abolished K+ channel dysregulation-induced neuronal hyperexcitability after oxaliplatin treatment. Mechanical allodynia and cold hyperalgesia of mice receiving an accumulation of 15 mg/kg oxaliplatin, with or without intraperitoneal sodium butyrate supplementation, were assessed using von Frey test and acetone evaporation test. Differential expressions of histone deacetylases (HDACs) and pain-related K+ channels were quantified with rt-qPCR and protein assays. Immunofluorescence assays of histone acetylation at H3K9/14 were performed in primary DRG cultures treated with sodium butyrate. Current clamp recording of action potentials and persistent outward current of Twik-related-spinal cord K+ (TRESK) channel were recorded in DRG neurons with small diameters extract. Accompanied by mechanical allodynia and cold hyperalgesia, HDAC1 was upregulated in mice receiving oxaliplatin treatment. Sodium butyrate enhanced global histone acetylation at H3K9/14 in DRG neurons. In vivo sodium butyrate supplementation restored oxaliplatin-induced Kcnj9 and Kcnk18 expression and pain-related behaviors in mice for at least 14 days. Oxaliplatin-induced increase in action potentials frequencies and decrease in magnitudes of KCNK18-related current were reversed in mice receiving sodium butyrate supplementation. This study suggests that sodium butyrate was a useful agent to relieve oxaliplatin-mediated neuropathic pain.
Expansion of memory Vδ2 T cells following SARS-CoV-2 vaccination revealed by temporal single-cell transcriptomics
Sara Terzoli, Paolo Marzano, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Simone Balin, Michela Calvi, Anna Carletti, Assunta Cancellara, Nicolò Coianiz, Sara Franzese, Alessandro Frigo, Antonio Voza, Francesca Calcaterra, Clara Di Vito, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Npj Vaccines, 2024
γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. While the first dose of vaccine primes Vδ2 T cells, it is the second administration that significantly boosts their immune response. Specifically, the second vaccination uncovers memory features of Vδ2 T cells, shaped by the induction of AP-1 family transcription factors and characterized by a convergent central memory signature, clonal expansion, and an enhanced effector potential. This temporally distinct effector response of Vδ2 T cells was also confirmed in vitro upon stimulation with SARS-CoV-2 spike-peptides. Indeed, the second challenge triggers a significantly higher production of IFNγ by Vδ2 T cells. Collectively, our findings suggest that mRNA SARS-CoV-2 vaccination might benefit from the establishment of long-lasting central memory Vδ2 T cells to confer protection against SARS-CoV-2 infection.
Human γδT cell identification from single-cell RNA sequencing datasets by modular TCR expression
Zheng Song, Lara Henze, Christian Casar, Dorothee Schwinge, Christoph Schramm, Johannes Fuss, Likai Tan, Immo Prinz
Journal of Leukocyte Biology, 2023
Erratum: A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (Cell Reports (2023) 42(3), (S2211124723002644), (10.1016/j.celrep.2023.112253))
Anne M. Hahn, Lisa Vogg, Stefanie Brey, Andrea Schneider, Simon Schäfer, Ralph Palmisano, Anna Pavlova, Inga Sandrock, Likai Tan, Alina S. Fichtner, Immo Prinz, Sarina Ravens, Thomas H. Winkler
Cell Reports, 2023
A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages
Anne M. Hahn, Lisa Vogg, Stefanie Brey, Andrea Schneider, Simon Schäfer, Ralph Palmisano, Anna Pavlova, Inga Sandrock, Likai Tan, Alina S. Fichtner, Immo Prinz, Sarina Ravens, Thomas H. Winkler
Cell Reports, 2023
Transcriptomic profile of TNFhigh MAIT cells is linked to B cell response following SARS-CoV-2 vaccination
Paolo Marzano, Simone Balin, Sara Terzoli, Silvia Della Bella, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Francesca Calcaterra, Clara Di Vito, Assunta Cancellara, Michela Calvi, Anna Carletti, Sara Franzese, Alessandro Frigo, Ahmed Darwish, Antonio Voza, Joanna Mikulak, Domenico Mavilio
Frontiers in Immunology, 2023
Corrigendum: Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status(Front. Immunol., (2022), 13, (960920), 10.3389/fimmu.2022.960920)
Lihua Deng, Anna Harms, Sarina Ravens, Immo Prinz, Likai Tan
Frontiers in Immunology, 2022
Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status
Lihua Deng, Anna Harms, Sarina Ravens, Immo Prinz, Likai Tan
Frontiers in Immunology, 2022
A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR
Malte Deseke, Francesca Rampoldi, Inga Sandrock, Eva Borst, Heike Böning, George Liam Ssebyatika, Carina Jürgens, Nina Plückebaum, Maleen Beck, Ahmed Hassan, Likai Tan, Abdi Demera, Anika Janssen, Peter Steinberger, Christian Koenecke, Abel Viejo-Borbolla, Martin Messerle, Thomas Krey, Immo Prinz
Journal of Experimental Medicine, 2022
Dopamine Signaling Promotes Tissue-Resident Memory Differentiation of CD8+ T Cells and Antitumor Immunity
Yingshi Chen, Shu-Mei Yan, Zeyu Pu, Jinzhu Feng, Likai Tan, Yuzhuang Li, Hongrong Hu, Wenjing Huang, Yingtong Lin, Zhilin Peng, Xin He, Feng Huang, Hui Zhang, Yiwen Zhang
Cancer Research, 2022
New insights on murine γδ T cells from single-cell multi-omics
Likai Tan, Daniel Inácio, Immo Prinz, Bruno Silva-Santos
Science Bulletin, 2022
γδ T cells license immature B cells to produce a broad range of polyreactive antibodies
Francesca Rampoldi, Elisa Donato, Leon Ullrich, Malte Deseke, Anika Janssen, Abdi Demera, Inga Sandrock, Anja Bubke, Anna-Lena Juergens, Maxine Swallow, Tim Sparwasser, Christine Falk, Likai Tan, Andreas Trumpp, Immo Prinz
Cell Reports, 2022
Clonal expansion of CD81 T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI
Christian R. Schultze-Florey, Leonie Kuhlmann, Solaiman Raha, Joana Barros-Martins, Ivan Odak, Likai Tan, Yankai Xiao, Sarina Ravens, Lothar Hambach, Letizia Venturini, Michael Stadler, Matthias Eder, Felicitas Thol, Michael Heuser, Reinhold Förster, Arnold Ganser, Immo Prinz, Christian Koenecke
Blood Advances, 2021
NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions
Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico S. Colombo, Enrico Lugli, Emanuela Marcenaro, Eric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Cell Reports, 2021
Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2
Shuyong Zhu, Nancy Stanslowsky, Jorge Fernández-Trillo, Tamrat M. Mamo, Pengfei Yu, Norman Kalmbach, Birgit Ritter, Reto Eggenschwiler, Werner J.D. Ouwendijk, David Mzinza, Likai Tan, Andreas Leffler, Michael Spohn, Richard J.P. Brown, Kai A. Kropp, Volkhard Kaever, Teng-Cheong Ha, Pratibha Narayanan, Adam Grundhoff, Reinhold Förster, Axel Schambach, Georges M.G.M. Verjans, Manuela Schmidt, Andreas Kispert, Tobias Cantz, Ana Gomis, Florian Wegner, Abel Viejo-Borbolla
Stem Cell Research, 2021
Amino acids and RagD potentiate mTORC1 activation in CD8 + T cells to confer antitumor immunity
Yiwen Zhang, Hongrong Hu, Weiwei Liu, Shu-Mei Yan, Yuzhuang Li, Likai Tan, Yingshi Chen, Jun Liu, Zhilin Peng, Yaochang Yuan, Wenjing Huang, Fei Yu, Xin He, Bo Li, Hui Zhang
Journal for Immunotherapy of Cancer, 2021
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood
Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F. Krebs, Sarina Ravens, Immo Prinz
Science Immunology, 2021
B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression
Nadine Eckert, Kathrin Werth, Stefanie Willenzon, Likai Tan, Reinhold Förster
Journal of Leukocyte Biology, 2020
TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults
Alina S Fichtner, Anja Bubke, Francesca Rampoldi, Anneke Wilharm, Likai Tan, Lars Steinbrück, Christian Schultze-Florey, Constantin von Kaisenberg, Immo Prinz, Thomas Herrmann, Sarina Ravens
Journal of Leukocyte Biology, 2020
Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells
Likai Tan, Inga Sandrock, Ivan Odak, Yuval Aizenbud, Anneke Wilharm, Joana Barros-Martins, Yaara Tabib, Alina Borchers, Tiago Amado, Lahiru Gangoda, Marco J. Herold, Marc Schmidt-Supprian, Jan Kisielow, Bruno Silva-Santos, Christian Koenecke, Avi-Hai Hovav, Christian Krebs, Immo Prinz, Sarina Ravens
Cell Reports, 2019
Genetic models reveal origin, persistence and nonredundant functions of IL-17-producing γδ T cells
Inga Sandrock, Annika Reinhardt, Sarina Ravens, Christoph Binz, Anneke Wilharm, Joana Martins, Linda Oberdörfer, Likai Tan, Stefan Lienenklaus, Baojun Zhang, Ronald Naumann, Yuan Zhuang, Andreas Krueger, Reinhold Förster, Immo Prinz
Journal of Experimental Medicine, 2018
Nonsteroidal anti-inflammatory drugs potently inhibit the replication of zika viruses by inducing the degradation of AXL
Ting Pan, Zhilin Peng, Likai Tan, Fan Zou, Nan Zhou, Bingfeng Liu, Liting Liang, Cancan Chen, Jun Liu, Liyang Wu, Guangyan Liu, Zhiqin Peng, Weiwei Liu, Xiancai Ma, Junsong Zhang, Xun Zhu, Ting Liu, Mengfeng Li, Xi Huang, Liang Tao, Yiwen Zhang, Hui Zhang
Journal of Virology, 2018
Identification of a novel compound targeting the nuclear export of influenza A virus nucleoprotein
Feng Huang, Jingliang Chen, Junsong Zhang, Likai Tan, Gui Lu, Yongjie Luo, Ting Pan, Juanran Liang, Qianwen Li, Baohong Luo, Hui Zhang, Gen Lu
Journal of Cellular and Molecular Medicine, 2018
Characteristic amino acid changes of influenza A(H1N1)pdm09 virus PA protein enhance A(H7N9) viral polymerase activity
Jun Liu, Feng Huang, Junsong Zhang, Likai Tan, Gen Lu, Xu Zhang, Hui Zhang
Virus Genes, 2016
Host protein Moloney leukemia virus 10 (MOV10) acts as a restriction factor of influenza A virus by inhibiting the nuclear import of the viral nucleoprotein
Junsong Zhang, Feng Huang, Likai Tan, Chuan Bai, Bing Chen, Jun Liu, Juanran Liang, Chao Liu, Shaoying Zhang, Gen Lu, Yuan Chen, Hui Zhang
Journal of Virology, 2016
A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus
Likai Tan, Shuo Su, David K. Smith, Shuyi He, Yun Zheng, Zhenwen Shao, Jun Ma, Huachen Zhu, Guihong Zhang
Journal of Virology, 2014
Avian-like a (H1N1) swine influenza virus antibodies among swine farm residents and pigs in Southern China
Han Zhou, Zhenpeng Cao, Likai Tan, Xinliang Fu, Gang Lu, Wenbao Qi, Changwen Ke, Heng Wang, Lingshuang Sun, Guihong Zhang
Japanese Journal of Infectious Diseases, 2014
Avian influenza A (H5N1) virus antibodies in pigs and residents of swine farms, southern China
Nan Cao, Wanjun Zhu, Ye Chen, Likai Tan, Pei Zhou, Zhenpeng Cao, Changwen Ke, Yugu Li, Jie Wu, Wenbao Qi, Peirong Jiao, Guihong Zhang
Journal of Clinical Virology, 2013
Avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong, China
Shuo Su, Ye Chen, Fu-Rong Zhao, Ji-Dang Chen, Jie-Xiong Xie, Zhong-Ming Chen, Zhen Huang, Yi-Ming Hu, Min-Ze Zhang, Li-Kai Tan, Gui-Hong Zhang, Shou-Jun Li
Infection Genetics and Evolution, 2013
Corrigendum to "Avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong, China" [Inf. Gen. Evol. 14 (2013) 444-449]
Infection Genetics and Evolution, 2013
Serologic reports of H3N2 canine influenza virus infection in dogs in northeast China
Yong-Biao ZHANG, Ji-Dang CHEN, Jie-Xiong XIE, Wan-Jun ZHU, Chun-Ya WEI, Li-Kai TAN, Nan CAO, Ye CHEN, Min-Ze ZHANG, Gui-Hong ZHANG, Shou-Jun LI
Journal of Veterinary Medical Science, 2013
Genetic characterization of avian-origin H3N2 canine influenza viruses isolated from Guangdong during 2006-2012
Heng Wang, Kun Jia, Wenbao Qi, Minze Zhang, Long Sun, Huanbin Liang, Guohao Du, Likai Tan, Zhenwen Shao, Jiahui Ye, Lingshuang Sun, Zhenpeng Cao, Ye Chen, Pei Zhou, Shuo Su, Shoujun Li
Virus Genes, 2013
Lack of evidence of avian-to-human transmission of avian influenza A (H5N1) virus among veterinarians, Guangdong, China, 2012
Shuo Su, Zhangyong Ning, Wanjun Zhu, Peirong Jiao, Changwen Ke, Wenbao Qi, Zhen Huang, Jin Tian, Lan Cao, Likai Tan, Zhenwen Shao, Huanbin Liang, Wenming Huang, Ming Liao, Shoujun Li, Guihong Zhang
Journal of Clinical Virology, 2013
Avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong, China
Shuo Su, Hua-Tao Li, Fu-Rong Zhao, Ji-Dang Chen, Jie-xiong Xie, Zhong-Ming Chen, Zhen Huang, Yi-Ming Hu, Min-Ze Zhang, Li-Kai Tan, Gui-Hong Zhang, Shou-Jun Li
Infection Genetics and Evolution, 2013
Serological surveillance of swine influenza virus infection in seven cities located in Guangdong province, South China in 2010
Gui-Hong Zhang, Fei-Xia Gu, Wen-Bao Qi, Shuo Su, Ji-Dang Chen, Hai-Tao Qi, Wan-Jun Zhu, Zhen Huang, Li-Kai Tan
Journal of Animal and Veterinary Advances, 2012
Amplification of nucleoprotein (NP) gene from canine influenza virus H3N2 and its expression in Escherichia coli
Li Shou-Jun, Wang Li, Guo Yu-Fei, Qi Hai-Tao, Su Shuo, Chen Ji-Dang, Zhao Fu-Rong, Cao Nan, Zhang Min-Ze, Zhang Chao-Yi, Huang Zhen, Tan Li-Kai, Zhang Gui-Hong
Journal of Animal and Veterinary Advances, 2012

Likai Tan

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