Jose Julio Ferreira Pacheco

@cespu.pt

Jose Julio Ferreira Pacheco


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https://researchid.co/jjpacheco
36

Scopus Publications

1367

Scholar Citations

19

Scholar h-index

30

Scholar i10-index

Scopus Publications

  • Laser treatment of oral vascular anomalies. A retrospective observational study
    L. Monteiro, C. Fazendeiro, S. Ferreira, L. Delgado, JJ. Pacheco, F. Salazar
    Medicina Oral Patologia Oral Y Cirugia Bucal, 2026
    BACKGROUND: Oral vascular anomalies, though benign, may impact comfort and aesthetics, particularly in visible or functional areas. Laser therapies have gained prominence due to their precision, minimal invasiveness, and favourable outcomes. This study aimed to analyse the laser treatment modalities for oral vascular anomalies and their respective outcomes in a population of the north of Portugal. MATERIAL AND METHODS: This retrospective study analysed 111 vascular anomalies in 95 patients treated between January 2011 and May 2025 in the University Clinics of IUCS-CESPU. Data on demographics, type and location of vascular anomalies, treatment (Nd:YAG, CO2 or diode laser), and outcomes were collected. RESULTS: Venous lakes were the most frequent diagnosis (n=77;69.4%) and lip was the most common location (n=81;73%). Induced photocoagulation (IPC) (n=79;71.2%), essentially with Nd:YAG, was the predominant technique. Recurrence was observed in 4 cases (3.6%), healing occurred mostly ≤21 days (n=88; 79.3%), scar tissue was present in 10 cases (9%), pain was reported in 29 patients (26.1%) (mean of 0.85±0.14), and satisfaction was high (n=103; 92.8%). No major complications were observed. Logistic regression analysis showed that larger vascular anomalies were associated with delayed healing (p=0.009) and scar formation correlated with presence of pain (one day after intervention) (p=0.03) and recurrence (p=0.039). CONCLUSIONS: Laser-based management in particular, IPC, is a safe, effective, and well tolerated option for the treatment of small oral vascular anomalies. Prospective studies are encouraged to optimize protocols and standardize the technique.
  • Evaluation of the Tunnelling Technique for Upper Labial Frenectomy Using ER:YAG Laser
    L. Monteiro, I. Álvaro, S. Ferreira, L. Delgado, T. Vale, JJ. Pacheco, F. Salazar
    Journal of Clinical and Experimental Dentistry, 2026
    Background: An abnormal upper labial frenum (ULF) can represent a potentially harmful gingival insertion located between the central incisors. Lasers, particularly the Er:YAG laser, have been described for ULF frenectomy and offer several promising advantages. The aim of this study was to evaluate the usefulness of Er:YAG laser frenectomy using the "tunnelization technique" for the elimination of an abnormal upper labial frenum. Material and Methods: This cohort study evaluated ULF frenectomy using the tunnelling technique with an Er:YAG laser in a cohort of 20 patients treated between January 2011 and December 2024. The ULFs were morphologically and clinically characterized before and after the procedure. Results: No intraoperative complications were observed during the frenectomy, apart from moderate intraoperative bleeding in 12 patients (60%), with no sutures required in any case. Postoperatively, analgesic medication was required by only 2 patients (10%) for mild pain. At the 3-month follow-up, a significant reduction was observed in both frenulum size (P<0.001) and interincisal diastema (P=0.008). All incisive papillae were preserved without any defects. Conclusions: Er:YAG laser frenectomy using the tunneling technique proved to be a suitable option, resulting in the immediate preservation of the incisive papilla and a reduction in ULF size and position, without significant associated complications.
  • Genetic Polymorphisms and Predisposition to Peri-Implantitis: A Systematic Review
    Filomena Salazar, María Belén Alvarez, Marta Relvas, José Julio Pacheco, Marco Infante da Câmara, José Adriano Costa
    International Journal of Molecular Sciences, 2025
    Peri-implantitis is a multifactorial inflammatory disease that can compromise the longevity of dental implants. Several studies have investigated the association between genetic variants. This systematic review aimed to assess the contribution of genetic polymorphisms to the risk of developing peri-implantitis. A systematic search was conducted in the PubMed database up to 2025 following the PICO strategy and PRISMA guidelines. Eligible studies met the following inclusion criteria: articles written in English, addressing genetic associations with peri-implantitis in human subjects, designed as clinical trials or observational (prospective or retrospective) studies, with full-text availability, and published within the last ten years. Exclusion criteria included studies in languages other than English, those not addressing the main research question, publications older than ten years, studies without full text, and secondary research such as meta-analyses or review articles. Selection and data extraction were performed independently by two reviewers. Risk of bias was evaluated qualitatively for control studies. Twenty-three studies met the inclusion criteria. Polymorphisms in genes related to inflammatory cytokines (e.g., IL-1β +3954 C/T, IL-10, TNF-α), bone metabolism (OPG, BMP4, FGF10), and immune regulation (CD14 rs2569190, miR-27a-3p) were frequently reported. IL-1β +3954 C/T, ET-1 and IL-1β, MMP-8 rs11225395 (T allele), MMP8 (−799 C/T), and CD14 rs2569190 showed consistent associations with increased peri-implantitis risk, while the results for TNF-α −308 G/A were inconsistent across populations. These findings suggest a potential role of genetic predisposition in peri-implantitis development. Identifying genetic biomarkers may help predict susceptibility and personalize management strategies.
  • Tissue Biomarkers for Predicting the Risk of Oral Cancer in Patients Diagnosed With Oral Leukoplakia: A Systematic Review of the Past 4 Years
    Luís Monteiro, Elia Rocha, Sara Ferreira, Filomena Salazar, José Júlio Pacheco, Saman Warnakulasuriya
    Journal of Oral Pathology and Medicine, 2025
    BackgroundOral potentially malignant disorders may precede the development of oral cancer, and biomarkers are being investigated for their risk assessment. We aim to provide updated information on tissue biomarkers related to the risk of malignant transformation (MT) in patients with oral leukoplakia (OL) published during the last four years.MethodsA search strategy was developed using the electronic databases PubMed, EBSCO, and Cochrane Library to search for articles related to this topic (published from 2020 to 2024) (CRD42024527395).ResultsOf the 1385 articles identified, 14 were included, with a combined sample of 1479 patients of whom 216 suffered MT. There were 30 different biomarkers evaluated of which Bmi‐1, CD3/CD8, Ki‐67, p16, and DNA ploidy were evaluated in more than one study. Of the 9 studies with multivariate analysis, Bmi‐1, Tipe‐2, copy number alteration, DcR2, and Ki‐67, PTHrP, podoplanin (PDPN), and BubR1/Mad2 biomarkers presented independent significant value on MT. In one study, adding DNA ploidy status to the grade of dysplasia increased the model's predictive power.ConclusionAlthough heterogeneity continues to exist, this systematic review reconfirms the role of biomarkers previously described such as PDPN and DNA ploidy and some new additional biomarkers.
  • The Relationship of HbA1c Serum Levels with the Severity of Periodontal Disease in Patients with Type 1 Diabetes Mellitus: A Cross-Sectional Study
    Rosana Costa, Marco Infante da Câmara, Fernando Figueira, José Júlio Pacheco, Catarina Pereira, Maria Gonçalves, Marta Relvas
    European Journal of Dentistry, 2025
    Objective According to the evidence, the level of glycemic control is of key importance in determining the increased risk of periodontal disease (PD). The aim of the study was to evaluate the role of metabolic control as a key factor leading to the development and severity of periodontitis and compare the periodontal and oral hygiene status with the glycated hemoglobin levels. Materials and Methods The evaluation was undertaken with diabetic patients (59 uncontrolled diabetics and 36 controlled diabetics) from a patient cohort of the Hospitalar Center of Tâmega e Sousa and subjects without diabetes (n = 95). Statistical Analysis The data were analyzed using IBM SPSS Statistics software (Statistical Program for Social Sciences), version 29.0 for Windows. In the logistic regression analysis, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The significance level was set at 0.05. Results Periodontal parameters were increased in systemically compromised individuals especially those who were poorly controlled as compared with their healthy counterparts, which are important indicators of PD progression. Furthermore, uncontrolled type 1 diabetic mellitus (T1DM) patients showed increased plaque index (PI), which predisposes these individuals to a greater degree of periodontal destruction and tooth loss. Using a binary logistic regression, we observe a significant relation of the risk of severe periodontitis in T1DM subjects with family history of T1DM (p = 0.019; OR: 3.36; 95% CI: 1.22–9.21), alcohol consumption (p = 0.02; OR: 3.78; 95% CI: 1.23–11.63), periodontal probing depth (PPD) (p < 0.001; OR: 3.64; 95% CI: 14.74–90.34), and clinical attachment loss (p = 0.033; OR: 4.71; 95% CI: 1.13–19.59). Conclusion Increased glycated hemoglobin levels were positively related with periodontal status. Uncontrolled systemically compromised individuals showed an increased Plaque index (PI), which predisposes to greater periodontal inflammation and tooth loss. Increased clinical attachment level, Periodontal probing depth (PPD) and family history of T1DM, and alcohol consumption were identified as potential risk factors for severe periodontitis in subjects with T1DM.
  • Osteonecrosis of the Jaw Associated with Bisphosphonates Infusion for Treatment of Plasma Cell Myeloma—A Retrospective Observational Study of Northern Portuguese Population
    Sara Sousa Ferreira, José Barbas do Amaral, José Júlio Pacheco, Filomena Salazar, Luís Monteiro
    Journal of Clinical Medicine, 2024
    Objectives: To verify medication-related osteonecrosis of the jaw (MRONJ) frequency among patients with plasma cell myeloma (PCM) that had been treated with bisphosphonates, to identify predisposing factors that could influence the development of osteonecrosis. Methods: This observational retrospective study was performed at the Department of Hematology of Hospital Center of Porto (CHUP), Portugal. Results: The study population (n = 112) had a 15.2% (n = 17) prevalence of osteonecrosis. Clinically, bone exposure was the most frequently observed sign, present in 100% (n = 17) of the patients, followed by inflammation in 82.4% (n = 14), orofacial pain in 70.6% (n = 12), suppuration in 47.1% (n = 8), and intra or extra-oral fistula in 17.6% (n = 3) of the cases. The most frequent triggering local factor was dental extraction (82.4%). There was a dependence between the presence of extractions and the development of MRONJ (p < 0.001) but not with the time elapsed from the initiation of infusions with BPs and dental extractions (p = 0.499). In the sample of patients with multiple myeloma (MM), 13.8% were found to be more likely to develop MRONJ after an extraction. Conclusions: The most common local predisposing factor was dental extraction. No dependence was observed between the development of osteonecrosis and the time elapsed from the beginning of treatment with bisphosphonates infusions to surgical procedures.
  • Osseodensification vs. Conventional Osteotomy: A Case Series with Cone Beam Computed Tomography
    José Adriano Costa, José Manuel Mendes, Filomena Salazar, José Júlio Pacheco, Paulo Rompante, Joaquim Ferreira Moreira, José Diogo Mesquita, Nuno Adubeiro, Marco Infante da Câmara
    Journal of Clinical Medicine, 2024
    Introduction: Osseodensification is a non-extraction technique using specially designed drills to increase bone density while extending an osteotomy, allowing bone to be preserved and condensed by compacting autograft during osteotomy preparation, increasing bone density around implants, and improving mechanical stability. Aim: The objective of this study is to compare conventional osteotomy and osseodensification protocols in implant placement and analyze whether there are differences in bone density. Materials and Methods: Study variables were defined, namely, osseodensification technique, conventional osteotomy technique, bone density, sex, area of location, implant dimensions, implant dimensions, and implant stability. Eligibility and exclusion criteria were defined. A step-by-step surgical protocol was developed. The surgeon and radiologist underwent intra-examiner calibration. A total of 15 patients were selected according to the eligibility criteria, and a total of 41 implants were inserted, 20 implants by conventional osteotomy and 21 by osseodensification. A cone beam computed tomography was performed one year after prosthetic rehabilitation to estimate bone density. Data were collected and recorded, and in the analysis of the association of variables, non-parametric tests were applied. Results: Significant statistical results were found in bone density values, with higher values being obtained with the osseodensification technique, that is, median density values of 1020, and median density values of 732 for the bone drilling technique. The results of the correlation between bone density in both techniques and sex, primary implant stability, implant dimensions and location area were statistically non-significant. Conclusions: Within the limitations of this study, there are differences in bone density between conventional osteotomy and osseodensification protocols. Bone density is increased with osseodensification over a study period of one year.
  • Analysis of peri-implant bone defects by using cone beam computed tomography (CBCT): an integrative review
    J. A. Costa, J. M. Mendes, F. Salazar, J. J. Pacheco, P. Rompante, M. I. Câmara
    Oral Radiology, 2023
    The objective of this work was to perform an integrative review of the inspection of peri-implant bone defects using cone beam computed tomography (CBCT). An electronic search was performed in the PubMed database using the following scientific terms: CBCT or Cone Beam computed tomography; dental implant; peri-implant; bone loss; defects. The survey identified 267 studies, of which 18 were considered relevant to this study. These studies provided important data taking into account the accuracy of cone beam computed tomography in the detection and measurement of peri-implant bone defects such as fenestrations, dehiscence and intraosseous circumferential defects. The effectiveness of CBCT in aiding in geometric bone calculations and in the diagnosis of peri-implant defects was influenced by factors such as artefacts, defect size, bone wall thickness, implant material, adjustment of acquisition parameters and observer experience. A not insignificant number of studies compared intraoral radiography to CBCT in the detection of peri-implant bone loss. CBCT was clearly superior to intraoral radiography in the detection of all peri-implant bone defects, except for defects located in the interproximal zone. In general, studies have shown that peri-implant bone measurements adjacent to the implant surface can be correctly determined, as well as the diagnosis of peri-implant bone defects with an average discrepancy of less than 1 mm from the actual measurement of the defect.
  • Assessment of Oral Health Status in a Prison Population in Northern Portugal
    M. Soares, M. Gonçalves, P. Rompante, F. Salazar, L. Monteiro, J. Pacheco, M. Relvas
    Journal of Clinical and Experimental Dentistry, 2023
    Background: Prisoners constitute one of the disadvantaged groups and it is observed that these individuals suffer from poor oral hygiene and the prevalence of oral diseases is higher compared to the general population. Material and Methods: The aim of this study is to assess the state of the oral health in a prison population in Northern Portugal. A cross-sectional observational study was conducted involving 103 male prisoners with age between 25 and 75 years old. A questionnaire was presented to all the prisoners and an intraoral clinical examination was performed in each of them. Results: The sample mean age was 41.58 ± 8.94 years. Most participants consume sugary foods, with 32% consuming then on a daily basis. It was noticed that 13.6% of the participants do not brush their teeth. Most of the prisoners smoke (78.6%) and 70 smoke more than 10 cigarettes per day. The mean DMFT was 17.17 ± 8.23 and the component with the highest weight was the number of missing teeth, with a mean value of 13.14 ± 8.32. It was observed that 7 individuals are edentulous and 64 (62.1%) have caries lesions. It has been noted that of the 64 individuals presenting caries lesions, 47 (73.4%) eat sugary foods, however this relationship is not statistically significant. It was found that the prevalence of periodontal health was 26%, gingivitis was 32.3% and periodontitis was 41.7%. Plaque Index was evaluated according to the periodontal condition, it was observed a significantly lower level of plaque index in the periodontally healthy subjects compared to the subjects with gingivitis and the subjects with periodontitis. Conclusions: Prisoners, Oral health, Caries, DMFT, Periodontitis, Oral diseases.
  • Study of Prevalence, Severity and Risk Factors of Periodontal Disease in a Portuguese Population
    Marta Relvas, Paula López-Jarana, Luis Monteiro, José Júlio Pacheco, Ana Cristina Braga, Filomena Salazar
    Journal of Clinical Medicine, 2022
    Periodontal disease is a common worldwide oral inflammation/infection affecting tissues that surround and support teeth. This study aims to evaluate the prevalence, extent and severity of periodontal diseases and its risk factors, according to the most recent periodontal classification, in an adult population of Northern Portugal. This observational study collected data from clinical records of patients who attended the University Clinic of Gandra between April 2021 and April 2022. Of a total of 941 patients included, 457 (48.6%) had periodontitis, 253 (26.9%) had gingivitis and the remaining 231 (24.5%) were healthy patients. The prevalence of stage III severe periodontitis was 51.2%, more prevalent in males, and in the age group of 61–70 years. Gingivitis was more prevalent in females, and in the age group of 31–40 years; in both diseases, the most prevalent extension was the generalized one. Using a binary logistic regression, we observe a significant relation of the risk of periodontitis with age (p = 0.019; OR 1.033; 95% CI 1.005–1.062), tooth brushing (p = 0.002; OR 0.25; 95% CI 0.105–0.599) and dental flossing (p = 0.015; OR 0.63; 95% CI 0.09–0.768). This study revealed a high prevalence of periodontitis. Increased age, lack of tooth brushing and flossing were identified as potential risk factors for periodontitis in the investigated Portuguese population.
  • Podoplanin Expression Independently and Jointly with Oral Epithelial Dysplasia Grade Acts as a Potential Biomarker of Malignant Transformation in Oral Leukoplakia
    Luís Monteiro, Barbas do Amaral, Leonor Delgado, Fernanda Garcês, Filomena Salazar, José Júlio Pacheco, Carlos Lopes, Saman Warnakulasuriya
    Biomolecules, 2022
  • Relationship between dental and periodontal health status and the salivary microbiome: bacterial diversity, co-occurrence networks and predictive models
    M. Relvas, A. Regueira-Iglesias, C. Balsa-Castro, F. Salazar, J. J. Pacheco, C. Cabral, C. Henriques, I. Tomás
    Scientific Reports, 2021
  • Expression of spindle assembly checkpoint proteins bubr1 and mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: An observational cohort study
    L. Monteiro, P. Silva, L. Delgado, B. Amaral, F. Garcês, F. Salazar, JJ. Pacheco, C. Lopes, H. Bousbaa, S. Warnakulasuriya
    Medicina Oral Patologia Oral Y Cirugia Bucal, 2021
  • Photobiomodulation laser therapy in a Lenvatinib-related osteonecrosis of the jaw: A case report
    L. Monteiro, C. Vasconcelos, J. Pacheco, F. Salazar
    Journal of Clinical and Experimental Dentistry, 2021
  • Treatment of snoring disorder with a non-ablactive Er:YAG laser dual mode protocol. An interventional study
    L. Monteiro, A. Macedo, L. Corte-Real, F. Salazar, J. Ferreira-Pacheco
    Journal of Clinical and Experimental Dentistry, 2020
  • Effectiveness of Photobiomodulation in Temporomandibular Disorder-Related Pain Using a 635 nm Diode Laser: A Randomized, Blinded, and Placebo-Controlled Clinical Trial
    Luís Monteiro, Raquel Ferreira, Tiago Resende, José Júlio Pacheco, Filomena Salazar
    Photobiomodulation Photomedicine and Laser Surgery, 2020
  • A histological evaluation of the surgical margins from human oral fibrous-epithelial lesions excised with co2 laser, diode laser, er:Yag laser, nd:Yag laser, electrosurgical scalpel and cold scalpel
    L Monteiro, ML Delgado, F Garces, M Machado, F Ferreira, M Martins, F Salazar, JJ Pacheco
    Medicina Oral Patologia Oral Y Cirugia Bucal, 2019
  • Coffee is protective against oral and pharyngeal cancer: A systematic review and meta-analysis
    J Miranda, L Monteiro, R Albuquerque, JJ Pacheco, Z. Khan, J Lopez-Lopez, S Warnakulasuryia
    Medicina Oral Patologia Oral Y Cirugia Bucal, 2017
  • Type of surgical treatment and recurrence of oral leukoplakia: A retrospective clinical study
    L Monteiro, C Barbieri, S Warnakulasuriya, M Martins, F Salazar, JJ Pacheco, P Vescovi, M Meleti
    Medicina Oral Patologia Oral Y Cirugia Bucal, 2017
  • Oral cancer awareness and knowledge among residents in the Oporto city, Portugal
    Luís Silva Monteiro, Saman Warnakulasuriya, Suzana Cadilhe, Duarte Sousa, Pedro Ferreira Trancoso, Luís Antunes, Filomena Salazar, José Júlio Pacheco
    Journal of Investigative and Clinical Dentistry, 2016
  • Prognostic significance of CD44v6, p63, podoplanin and MMP-9 in oral squamous cell carcinomas
    LS Monteiro, ML Delgado, S Ricardo, B do Amaral, F Salazar, JJ Pacheco, CA Lopes, H Bousbaa, S Warnakulasuryia
    Oral Diseases, 2016
  • Full-mouth periodontal examination prior to and after nonsurgical treatment in chronic periodontitis patients
    Biomedical Research India, 2016
  • Outcomes of invitational and opportunistic oral cancer screening initiatives in Oporto, Portugal
    Luís Silva Monteiro, Filomena Salazar, Jose Júlio Pacheco, Marco Martins, Saman Warnakulasuriya
    Journal of Oral Pathology and Medicine, 2015
  • Er:YAG laser assisted treatment of central odontogenic fibroma of the mandible
    Luis Silva Monteiro, Marco Martins, José Júlio Pacheco, Filomena Salazar, João Magalhães, Paolo Vescovi, Marco Meleti
    Case Reports in Dentistry, 2015
  • Oral soft tissue biopsies in Oporto, Portugal: An eight year retrospective analysis
    MM Guedes, R Albuquerque, M Monteiro, CA Lopes, JB Amaral, JJ Pacheco, LS Monteiro
    Journal of Clinical and Experimental Dentistry, 2015
  • Aesthetic depigmentation of gingival smoker's melanosis using carbon dioxide lasers
    Luis Silva Monteiro, José Adriano Costa, Marco Infante da Câmara, Rui Albuquerque, Marco Martins, José Júlio Pacheco, Filomena Salazar, Fernando Figueira
    Case Reports in Dentistry, 2015
  • Treatment of an asymmetric malocclusion: a case report.
    Australian Orthodontic Journal, 2014
  • EMMPRIN expression in oral squamous cell carcinomas: Correlation with tumor proliferation and patient survival
    Luís Silva Monteiro, Maria Leonor Delgado, Sara Ricardo, Fernanda Garcez, Barbas do Amaral, José Júlio Pacheco, Carlos Lopes, Hassan Bousbaa
    Biomed Research International, 2014
  • Helicobacter pylori identification: A diagnostic/confirmatory method for evaluation
    B. Mesquita, M. J. Gonçalves, P. Pacheco, J. Lopes, F. Salazar, M. Relvas, C. Coelho, J. J. Pacheco, C. Velazco
    Current Microbiology, 2014
  • Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6
    Cátia Reis, A. V. DA COSTA, J. Guimarães, Diana Tuna, A. Braga, J. Pacheco, Fernando A. Arosa, F. Salazar, E. Cardoso
    Experimental and Therapeutic Medicine, 2014
  • Evaluation of partial-mouth recording systems of gingival parameters in a Portuguese adult population
    Marta Relvas, Pedro Diz, Corsina Velazco, José Luis Otero, José Julio Pacheco, Inmaculada Tomás
    Journal of Public Health Dentistry, 2013
  • Oral cancer awareness and knowledge in the city of Valongo, Portugal
    Luís Silva Monteiro, Filomena Salazar, Júlio Pacheco, Saman Warnakulasuriya
    International Journal of Dentistry, 2012
  • Posterior lingual bone depression diagnosis using 3D-computed tomography
    Luís Silva Monteiro, Marco Infante Da Câmara, Fausto Tadeu, Filomena Salazar, José Júlio Pacheco
    Revista Portuguesa De Estomatologia Medicina Dentaria E Cirurgia Maxilofacial, 2012
  • Tobacco and periodontal disease
    Ana Sofia Vinhas, José Júlio Pacheco
    Revista Portuguesa De Estomatologia Medicina Dentaria E Cirurgia Maxilofacial, 2008
  • Treatment of Papillon-Lefèvre syndrome periodontitis
    J. J. Pacheco, C. Coelho, F. Salazar, A. Contreras, J. Slots, C. H. Velazco
    Journal of Clinical Periodontology, 2002
  • Microbiological features of Papillon-Lefèvre syndrome periodontitis
    C. H. Velazco, C. Coelho, F. Salazar, A. Contreras, J. Slots, J. J. Pacheco
    Journal of Clinical Periodontology, 1999

RECENT SCHOLAR PUBLICATIONS

  • Evaluation of the Tunnelling Technique for Upper Labial Frenectomy Using ER: YAG Laser
    L Monteiro, I Álvaro, S Ferreira, L Delgado, T Vale, JJ Pacheco, F Salazar
    Journal of Clinical and Experimental Dentistry 18 (4), e433 , 2026
    2026
  • Genetic Polymorphisms and Predisposition to Peri-Implantitis: A Systematic Review
    F Salazar, MB Alvarez, M Relvas, JJ Pacheco, MI Câmara, JA Costa
    International Journal of Molecular Sciences 26 (23), 11461 , 2025
    2025
    Citations: 1
  • Laser treatment of oral vascular anomalies. A retrospective observational study
    L Monteiro, C Fazendeiro, S Ferreira, L Delgado, JJ Pacheco, F Salazar
    Medicina Oral, Patología Oral y Cirugía Bucal 31 (2), e180 , 2025
    2025
  • Tissue biomarkers for predicting the risk of oral cancer in patients diagnosed with oral leukoplakia: A systematic review of the past 4 years
    L Monteiro, E Rocha, S Ferreira, F Salazar, JJ Pacheco, ...
    Journal of Oral Pathology & Medicine 54 (5), 283-289 , 2025
    2025
    Citations: 8
  • The Relationship of HbA1c Serum Levels with the Severity of Periodontal Disease in Patients with Type 1 Diabetes Mellitus: A Cross-Sectional Study
    R Costa, MI da Câmara, F Figueira, JJ Pacheco, C Pereira, M Gonçalves, ...
    European Journal of Dentistry 19 (02), 438-448 , 2025
    2025
    Citations: 3
  • Osteonecrosis of the Jaw Associated with Bisphosphonates Infusion for Treatment of Plasma Cell Myeloma—A Retrospective Observational Study of Northern Portuguese Population
    SS Ferreira, JB Amaral, JJ Pacheco, F Salazar, L Monteiro
    Journal of Clinical Medicine 13 (9), 2679 , 2024
    2024
    Citations: 1
  • Osseodensification vs. conventional osteotomy: A case series with cone beam computed tomography
    JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, JF Moreira, ...
    Journal of Clinical Medicine 13 (6), 1568 , 2024
    2024
    Citations: 15
  • Assessment of oral health status in a prison population in Northern Portugal
    M Soares, M Gonçalves, P Rompante, F Salazar, L Monteiro, JJ Pacheco, ...
    Journal of Clinical and Experimental Dentistry 15 (11), e912 , 2023
    2023
    Citations: 14
  • Analysis of peri-implant bone defects by using cone beam computed tomography (CBCT): an integrative review
    JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, MI Câmara
    Oral Radiology 39 (3), 455-466 , 2023
    2023
    Citations: 35
  • Is there an association between dental visit frequency and the risk of oral cancer? A systematic review and meta-analysis
    L Mariano, F Salazar, JJ Pacheco, S Warnakulasuriya, L Monteiro
    EDITORIAL COUNCIL, 78 , 2023
    2023
  • Efficacy of laser therapy in the treatment of Oral Lichen Planus lesions: an integrative review
    M Delgrosso, S Ferreira, JJ Pacheco, F Salazar, L Monteiro
    EDITORIAL COUNCIL, 58 , 2023
    2023
  • miRNA as salivary biomarkers and a useful tool in the early detection of oral cancer
    K Pisano, S Ferreira, JJ Pacheco, F Salazar, L Monteiro
    EDITORIAL COUNCIL, 57 , 2023
    2023
  • Study of prevalence, severity and risk factors of periodontal disease in a Portuguese population
    M Relvas, P López-Jarana, L Monteiro, JJ Pacheco, AC Braga, F Salazar
    Journal of clinical medicine 11 (13), 3728 , 2022
    2022
    Citations: 69
  • Podoplanin expression independently and jointly with oral epithelial dysplasia grade acts as a potential biomarker of malignant transformation in oral leukoplakia
    L Monteiro, B Do Amaral, L Delgado, F Garcês, F Salazar, JJ Pacheco, ...
    Biomolecules 12 (5), 606 , 2022
    2022
    Citations: 22
  • Expresión de las proteínas del punto de control del ensamblaje del huso BubR1 y Mad2 como potenciales biomarcadores de la transformación maligna de la leucoplasia oral: un …
    LS Monteiro, P Silva, ML Delgado, JB do Amaral, F Garces, F Salazar, ...
    Medicina oral, patología oral y cirugía bucal. Ed. española 27 (2), 97-106 , 2022
    2022
  • Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study
    L Monteiro, P Silva, L Delgado, B Amaral, F Garcês, F Salazar, ...
    Medicina oral, patologia oral y cirugia bucal 26 (6), e719 , 2021
    2021
    Citations: 14
  • Photobiomodulation laser therapy in a Lenvatinib-related osteonecrosis of the jaw: A case report
    L Monteiro, C Vasconcelos, JJ Pacheco, F Salazar
    Journal of Clinical and Experimental Dentistry 13 (6), e626 , 2021
    2021
    Citations: 26
  • Relationship between dental and periodontal health status and the salivary microbiome: bacterial diversity, co-occurrence networks and predictive models
    M Relvas, A Regueira-Iglesias, C Balsa-Castro, F Salazar, JJ Pacheco, ...
    Scientific reports 11 (1), 929 , 2021
    2021
    Citations: 74
  • Treatment of snoring disorder with a non-ablactive Er: YAG laser dual mode protocol. An interventional study
    L Monteiro, A Macedo, L Corte-Real, F Salazar, JJ Pacheco
    Journal of Clinical and Experimental Dentistry 12 (6), e561 , 2020
    2020
    Citations: 19
  • Assessing the impact of dental and periodontal statuses on the salivary microbiome: a global oral health scale
    M Relvas, A Regueira-Iglesias, C Balsa-Castro, F Salazar, JJ Pacheco, ...
    medRxiv, 2020.05. 16.20104190 , 2020
    2020
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6
    C Reis, AV Da Costa, JT Guimarães, D Tuna, AC Braga, JJ Pacheco, ...
    Experimental and therapeutic medicine 8 (1), 323-327 , 2014
    2014
    Citations: 134
  • Proceedings of the 3rd IPLeiria’s international health congress: Leiria, Portugal. 6-7 May 2016
    CC Tomás, E Oliveira, D Sousa, M Uba-Chupel, G Furtado, C Rocha, ...
    BMC Health Services Research 16 (Suppl 3), 200 , 2016
    2016
    Citations: 107
  • Treatment of Papillon‐Lefèvre syndrome periodontitis
    JJ Pacheco, C Coelho, F Salazar, A Contreras, J Slots, CH Velazco
    Journal of Clinical Periodontology: Case Report 29 (4), 370-374 , 2002
    2002
    Citations: 100
  • Microbiological features of Papillon‐Lefèvre syndrome periodontitis
    CH Velazco, C Coelho, F Salazar, A Contreras, J Slots, JJ Pacheco
    Journal of clinical periodontology 26 (9), 622-627 , 1999
    1999
    Citations: 93
  • A histological evaluation of the surgical margins from human oral fibrous-epithelial lesions excised with CO2 laser, Diode laser, Er: YAG laser, Nd: YAG laser, electrosurgical …
    L Monteiro, ML Delgado, F Garcês, M Machado, F Ferreira, M Martins, ...
    Medicina oral, patologia oral y cirugia bucal 24 (2), e271 , 2019
    2019
    Citations: 83
  • Type of surgical treatment and recurrence of oral leukoplakia: A retrospective clinical study
    L Monteiro, C Barbieri, S Warnakulasuriya, M Martins, F Salazar, ...
    Medicina oral, patologia oral y cirugia bucal 22 (5), e520 , 2017
    2017
    Citations: 79
  • Relationship between dental and periodontal health status and the salivary microbiome: bacterial diversity, co-occurrence networks and predictive models
    M Relvas, A Regueira-Iglesias, C Balsa-Castro, F Salazar, JJ Pacheco, ...
    Scientific reports 11 (1), 929 , 2021
    2021
    Citations: 74
  • Study of prevalence, severity and risk factors of periodontal disease in a Portuguese population
    M Relvas, P López-Jarana, L Monteiro, JJ Pacheco, AC Braga, F Salazar
    Journal of clinical medicine 11 (13), 3728 , 2022
    2022
    Citations: 69
  • EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival
    LS Monteiro, ML Delgado, S Ricardo, F Garcez, B Amaral, JJ Pacheco, ...
    BioMed research international 2014 (1), 905680 , 2014
    2014
    Citations: 63
  • Coffee is protective against oral and pharyngeal cancer: A systematic review and meta-analysis
    J Miranda, L Monteiro, R Albuquerque, JJ Pacheco, Z Khan, ...
    Medicina oral, patologia oral y cirugia bucal 22 (5), e554 , 2017
    2017
    Citations: 60
  • Oral cancer awareness and knowledge among residents in the Oporto city, Portugal
    LS Monteiro, S Warnakulasuriya, S Cadilhe, D Sousa, PF Trancoso, ...
    Journal of investigative and clinical dentistry 7 (3), 294-303 , 2016
    2016
    Citations: 47
  • Oral soft tissue biopsies in Oporto, Portugal: An eight year retrospective analysis
    MM Guedes, R Albuquerque, M Monteiro, CA Lopes, JB do Amaral, ...
    Journal of clinical and experimental dentistry 7 (5), e640 , 2015
    2015
    Citations: 45
  • Prognostic significance of CD44v6, p63, podoplanin and MMP‐9 in oral squamous cell carcinomas
    LS Monteiro, ML Delgado, S Ricardo, B do Amaral, F Salazar, JJ Pacheco, ...
    Oral Diseases 22 (4), 303-312 , 2016
    2016
    Citations: 44
  • Outcomes of invitational and opportunistic oral cancer screening initiatives in O porto, P ortugal
    LS Monteiro, F Salazar, JJ Pacheco, M Martins, S Warnakulasuriya
    Journal of Oral Pathology & Medicine 44 (2), 145-152 , 2015
    2015
    Citations: 38
  • Effectiveness of photobiomodulation in temporomandibular disorder-related pain using a 635 nm diode laser: A randomized, blinded, and placebo-controlled clinical trial
    L Monteiro, R Ferreira, T Resende, JJ Pacheco, F Salazar
    Photobiomodulation, Photomedicine, and Laser Surgery 38 (5), 280-288 , 2020
    2020
    Citations: 37
  • Analysis of peri-implant bone defects by using cone beam computed tomography (CBCT): an integrative review
    JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, MI Câmara
    Oral Radiology 39 (3), 455-466 , 2023
    2023
    Citations: 35
  • Aesthetic depigmentation of gingival smoker’s melanosis using carbon dioxide lasers
    LS Monteiro, JA Costa, MI da Câmara, R Albuquerque, M Martins, ...
    Case reports in dentistry 2015 (1), 510589 , 2015
    2015
    Citations: 28
  • Photobiomodulation laser therapy in a Lenvatinib-related osteonecrosis of the jaw: A case report
    L Monteiro, C Vasconcelos, JJ Pacheco, F Salazar
    Journal of Clinical and Experimental Dentistry 13 (6), e626 , 2021
    2021
    Citations: 26
  • Podoplanin expression independently and jointly with oral epithelial dysplasia grade acts as a potential biomarker of malignant transformation in oral leukoplakia
    L Monteiro, B Do Amaral, L Delgado, F Garcês, F Salazar, JJ Pacheco, ...
    Biomolecules 12 (5), 606 , 2022
    2022
    Citations: 22
  • Treatment of snoring disorder with a non-ablactive Er: YAG laser dual mode protocol. An interventional study
    L Monteiro, A Macedo, L Corte-Real, F Salazar, JJ Pacheco
    Journal of Clinical and Experimental Dentistry 12 (6), e561 , 2020
    2020
    Citations: 19