Evaluation of analytical performance of Sebia Capillarys 3 Octa electrophoresis method for serum protein electrophoresis Medical Journal of Malaysia, 2025
Correlation between anti-mullerian hormone with insulin resistance in polycystic ovarian syndrome: a systematic review and meta-analysis Mohd Zakwan Md Muslim, Aniza Mohammed Jelani, Noorazliyana Shafii, Najib Majdi Yaacob, Noor Azlin Azraini Che Soh, Hanim Afzan Ibrahim Journal of Ovarian Research, 2024 Background Epidemiological studies regarding the correlation between anti-Müllerian hormone (AMH) and insulin resistance (IR) in polycystic ovarian syndrome (PCOS) remain inconsistent. The primary aim of this study was to determine the correlations between AMH and IR in patients with PCOS and to explore the selected factors that influence the correlations. Methods We conducted systemic searches of online databases (PubMed, Science Direct, Taylor and Francis, Scopus, and ProQuest) from inception to December 20, 2023 and manual searches of the associated bibliographies to identify relevant studies. We then performed subgroup and sensitivity analyses to explore the sources of heterogeneity, followed by a publication bias risk assessment of the included studies using the Joanna Briggs Institute critical appraisal tool. We used a random-effects model to estimate the pooled correlations between AMH and the homeostatic model assessment for insulin resistance (HOMA-IR) in patients with polycystic ovarian syndrome (PCOS). Results Of the 4835 articles identified, 22 eligible relevant studies from three regions were included and identified as low risk of bias. The random-effects pooled correlation estimate was 0.089 (95% confidence interval [CI]: −0.040, 0.215), with substantial heterogeneity (I2 = 87%; τ2 = 0.0475, p < .001). Subgroup analyses showed that the study region did not influence the correlation estimates, and sensitivity analysis showed no significant alteration in the pooled correlation estimate or 95% CI values. No publication bias was observed. Conclusion There was a weak, statistically insignificant correlation between AMH and HOMA-IR in patients with PCOS. The correlation estimates did not vary according to the study participants’ regions.
Association between serum uric acid levels with essential hypertension and its metabolic variables in Hospital Universiti Sains Malaysia Medical Journal of Malaysia, 2024
Thyrotoxic periodic paralysis: A treatable cause of weakness Malta Medical Journal, 2022
Elevated CA 125 in A Male Patient with Lung Carcinoma: A Laboratory Perspective Julia Omar, Tuan Salwani Tuan Ismail, Nur Karyatee Kassim, Aniza Mohammed Jelani Iium Medical Journal Malaysia, 2022 CA 125 is a tumour marker that is widely used for the management of patients with ovarian malignancy. However, elevated CA 125 has been reported in various non-ovarian cancer patients, including males. This report describes a case of an elevated CA 125 level in a 49-year-old male patient who presented with chronic cough associated with constitutional symptoms. The patient was diagnosed with lung carcinoma based on radiological investigations and tissue histopathological examination. According to recent studies, CA 125 has a potential role as a marker for lung malignancies. However, questions arise about the effectiveness of its measurement for such patients due to its poor specificity and improper utilization of the test. This report focuses on the clinical role of CA 125, the appropriateness of the test request for this patient, the significance of the result, and its implications for the patient and laboratory management.
The Frequency and Cost of Redundant Biochemistry Test in Tertiary Teaching Hospital Malaysian Journal of Medicine and Health Sciences, 2022
INTERFERENCES OF HbA1c ANALYSIS IN HOSPITAL UNIVERSITI SAINS MALAYSIA – 3 YEARS STUDY NOORAZLIYANA SHAFII, NOOR AZLIN AZRAINI CHE SOH, TUAN SALWANI TUAN ISMAIL, JULIA OMAR, WAN NORLINA WAN AZMAN, ANIZA MAT JELANI, WAN NOR FAZILA HAFIZAN WAN NIK, IBRAHIM ISMAIL, NUR KARYATEE KASSIM, HANIM AFZAN IBRAHIM, NAJIB MAJDI YAACOB Malaysian Applied Biology, 2021 Haemoglobin A1c (HbA1c) is used to monitor glycaemic control and predict diabetic complications. Measurement of HbA1c can be interfered by haemoglobin (Hb) variant and other Hb derivatives include carbamylated Hb and elevated labile A1c. This study is to determine the percentages and type of interferences during HbA1c analysis and the percentages of non- reportable HbA1c results. This is a cross-sectional study using retrospective data of HbA1c. The HbA1c is measured on Biorad D10 using the ion-exchange high-performance liquid chromatography method. The data were analyzed using descriptive statistics. A total of 26,560 patients were included. The result showed the presence of interferences of 2269 (8.56%). The most common causes of the interferences were the Hb variant (8.48%) followed by carbamylated Hb and labile A1c (0.03% each). The non-reportable HbA1c results were 0.46% with the Hb variant contributed most of the causes. By knowing the presence of interferences particularly the Hb variant, the HbA1c results hopefully are interpreted with caution and correct management can be given to the patients.
Survey on serum protein electrophoresis and recommendations for standardised reporting Malaysian Journal of Pathology, 2021
Inappropriate positioning of separator gel in blood collection tube: A case report Malaysian Journal of Medicine and Health Sciences, 2021
Global prevalence of macroprolactinemia among patients with hyperprolactinemia: A systematic review and meta-analysis Noor Azlin Azraini Che Soh, Najib Majdi Yaacob, Julia Omar, Aniza Mohammed Jelani, Noorazliyana Shafii, Tuan Salwani Tuan Ismail, Wan Norlina Wan Azman, Anis Kausar Ghazali International Journal of Environmental Research and Public Health, 2020 Hyperprolactinemia (hPRL) often poses a diagnostic dilemma due to the presence of macroprolactin. Understanding the prevalence of macroprolactinemia (mPRL) has an important implication in managing patients with hPRL. The primary aim of this study was to determine the prevalence of mPRL globally and to explore selected factors influencing the prevalence estimate. Studies with original data related to the prevalence of mPRL among patients with hPRL from inception to March 2020 were identified, and a random effects meta-analysis was performed. Of the 3770 records identified, 67 eligible studies from 27 countries were included. The overall global prevalence estimate was 18.9% (95% CI: 15.8%, 22.1%) with a substantial statistical heterogeneity (I2 = 95.7%). The highest random effects pooled prevalence was observed in the African region (30.3%), followed by Region of the Americas (29.1%), European (17.5%), Eastern Mediterranean (13.9%), South-East Asian (12.7%), and Western Pacific Region (12.6%). Lower prevalence was observed in studies involving both sexes as compared to studies involving only female participants (17.1% vs. 25.4%) and in more recent studies (16.4%, 20.4%, and 26.5% in studies conducted after 2009, between 2000 and 2009, and before 2000, respectively). The prevalence estimate does not vary according to the age group of study participants, sample size, and types of polyethylene glycol (PEG) used for detection of macroprolactin (PEG 6000 or PEG 8000). With macroprolactin causing nearly one-fifth of hPRL cases, screening for mPRL should be made a routine before an investigation of other causes of hPRL.
Correlation between adiponectin and HDL-cholesterol in overweight adolescents International Medical Journal, 2017
A study of the factors related to intima-media thickness of the common carotid artery amongst rural middle age individuals in Hospital Universiti Sains Malaysia Southeast Asian Journal of Tropical Medicine and Public Health, 2006
