Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo Xuexiang Han, Ying Xu, Adele S. Ricciardi, Junchao Xu, Yan Xiang, Rohan Palanki, Vivek Chowdhary, Lulu Xue, Ningqiang Gong, Mohamad-Gabriel Alameh, William H. Peranteau, James M. Wilson, Daniel Reker, Drew Weissman, Michael J. Mitchell Proceedings of the National Academy of Sciences of the United States of America, 2026 mRNA-based gene editing therapeutics offer the potential to permanently cure diseases but are hindered by suboptimal delivery platforms. Here, we devise a robust combinatorial chemistry for the plug-and-play assembly of structurally diverse biodegradable ionizable lipids from amines/thiols and dialkyl maleates. After screening 500 ionizable lipids, we obtained structure−activity relationships essential for effective in vitro mRNA delivery with the help of machine learning. Furthermore, we identified a lead ionizable lipid candidate that produced potent lipid nanoparticles for the delivery of various gene editing tools in wild-type and genetically modified mice compared to literature and industry benchmark lipid nanoparticles. Mechanistically, our lipid nanoparticles show favorable physicochemical properties, which could synergistically contribute to the superior delivery performance. This study highlights the utility of this synthetic method as well as the generality of this platform for potent in vivo gene editing.
Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering Marshall S. Padilla, Kaitlin Mrksich, Yiming Wang, Rebecca M. Haley, Jacqueline J. Li, Emily L. Han, Rakan El-Mayta, Emily H. Kim, Sofia Dias, Ningqiang Gong, Sridatta V. Teerdhala, Xuexiang Han, Vivek Chowdhary, Lulu Xue, Zain Siddiqui, Hannah M. Yamagata, Dongyoon Kim, Il-Chul Yoon, James M. Wilson, Ravi Radhakrishnan, Michael J. Mitchell Nature Communications, 2025 Lipid nanoparticles (LNPs) are the preeminent non-viral drug delivery vehicle for mRNA-based therapies. Immense effort has been placed on optimizing the ionizable lipid (IL) structure, which contains an amine core conjugated to lipid tails, as small molecular adjustments can result in substantial changes in the overall efficacy of the resulting LNPs. However, despite some advancements, a major barrier for LNP delivery is endosomal escape. Here, we develop a platform for synthesizing a class of branched ILs that improve endosomal escape. These compounds incorporate terminally branched groups that increase hepatic mRNA and ribonucleoprotein complex delivery and gene editing efficiency as well as T cell transfection compared to non-branched lipids. Through an array of complementary experiments, we determine that our lipid architecture induces greater endosomal penetration and disruption. This work provides a scheme to generate a class of ILs for both mRNA and protein delivery. Lipid nanoparticles (LNPs) are the preeminent drug delivery vehicle for mRNA therapies, partially due to the ionizable lipid (IL) components that facilitate endosomal escape. Here, authors devise terminally branched ILs that enhance endosome escape, resulting in increased liver and T cell delivery.
The Responsible Development of Adeno-Associated Virus Gene Therapies James M Wilson, Arthur L. Caplan Human Gene Therapy, 2025 Several unexpected fatalities in patients who received adeno-associated virus (AAV)-based gene therapies have recently occurred. These tragic events have cast a pall over the entire sector with some stakeholders suggesting that AAV is patently unsafe as a gene delivery platform and ought not to be pursued. This conclusion is not warranted.
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors Xuexiang Han, Junchao Xu, Ying Xu, Mohamad-Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C. Warzecha, Gan Zhao, Andrew E. Vaughan, James M. Wilson, Drew Weissman, Michael J. Mitchell Nature Communications, 2024 The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devise an in situ construction method for the combinatorial synthesis of degradable branched (DB) lipidoids. We find that appending branch tails to inefficacious lipidoids via degradable linkers boosts mRNA delivery efficiency up to three orders of magnitude. Combinatorial screening and systematic investigation of two libraries of DB-lipidoids reveal important structural criteria that govern their in vivo potency. The lead DB-LNP demonstrates robust delivery of mRNA therapeutics and gene editors into the liver. In a diet-induced obese mouse model, we show that repeated administration of DB-LNP encapsulating mRNA encoding human fibroblast growth factor 21 alleviates obesity and fatty liver. Together, we offer a construction strategy for high-throughput and cost-efficient synthesis of DB-lipidoids. This study provides insights into branched lipidoids for efficient mRNA delivery.
Validation of high-sensitivity assays to quantitate cerebrospinal fluid and serum β-galactosidase activity in patients with GM1-gangliosidosis Karen J. Quadrini, Catherine Vrentas, Christian Duke, Chris Wilson, Christian J. Hinderer, David A. Weinstein, Samiah A. Al-Zaidy, Susan E. Browne, James M. Wilson, Yan G. Ni Molecular Therapy Methods and Clinical Development, 2024 gene replacement therapy. Assay analytical performance was characterized by assessing sensitivity, precision, accuracy, parallelism, specificity, and sample stability. Sensitivity of the CSF and serum β-gal activity assays were 0.05 and 0.20 nmol/mL/3 h, respectively. Assay precision represented by inter-assay percent coefficient of variation of the human CSF and serum was <15% and <20%, respectively. The effect of pre-analytical factors on β-gal activity was examined, and rapid processing and freezing of samples post-collection was critical to preserve enzyme activity. These assays enabled measurement of CSF and serum β-gal activities in both healthy individuals and patients with GM1-gangliosidosis. This CSF β-gal activity assay is the first of its kind with sufficient sensitivity to quantitatively measure β-gal enzyme activity in CSF samples from GM1 patients.
Treating Transthyretin Amyloidosis via Adeno-Associated Virus Vector Delivery of Meganucleases J. Greig, C. Breton, Scott N. Ashley, Kelly M. Martins, Cassandra L. Gorsuch, Joanna K Chorazeczewski, Thomas Furmanak, Melanie K. Smith, Yanqing Zhu, P. Bell, Wendy Shoop, Hui Li, Jeff Smith, Ginger H. Tomberlin, Peter M. Clark, T. Mitchell, E. Buza, Hanying Yan, D. Jantz, James M. Wilson Human Gene Therapy, 2022
Durable immunogenicity, adaptation to emerging variants, and low-dose efficacy of an AAV-based COVID-19 vaccine platform in macaques Nerea Zabaleta, Urja Bhatt, Cécile Hérate, Pauline Maisonnasse, Julio Sanmiguel, Cheikh Diop, Sofia Castore, Reynette Estelien, Dan Li, Nathalie Dereuddre-Bosquet, Mariangela Cavarelli, Anne-Sophie Gallouët, Quentin Pascal, Thibaut Naninck, Nidhal Kahlaoui, Julien Lemaitre, Francis Relouzat, Giuseppe Ronzitti, Hendrik Jan Thibaut, Emanuele Montomoli, James M. Wilson, Roger Le Grand, Luk H. Vandenberghe Molecular Therapy, 2022
Efficacy and Safety of a Krabbe Disease Gene Therapy Juliette Hordeaux, Brianne A. Jeffrey, Jinlong Jian, Gourav R. Choudhury, Kristofer Michalson, Thomas W. Mitchell, Elizabeth L. Buza, Jessica Chichester, Cecilia Dyer, Jessica Bagel, Charles H. Vite, Allison M. Bradbury, James M. Wilson Human Gene Therapy, 2022
Context-specific function of the engineered peptide domain of PHP.B R. Alexander Martino, Edwin C. Fluck, Jacqueline Murphy, Qiang Wang, Henry Hoff, Ruth A. Pumroy, Claudia Y. Lee, Joshua J. Sims, Soumitra Roy, Vera Y. Moiseenkova-Bell, James M. Wilson Journal of Virology, 2021
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates Nerea Zabaleta, Wenlong Dai, Urja Bhatt, Cécile Hérate, Pauline Maisonnasse, Jessica A. Chichester, Julio Sanmiguel, Reynette Estelien, Kristofer T. Michalson, Cheikh Diop, Dawid Maciorowski, Nathalie Dereuddre-Bosquet, Mariangela Cavarelli, Anne-Sophie Gallouët, Thibaut Naninck, Nidhal Kahlaoui, Julien Lemaitre, Wenbin Qi, Elissa Hudspeth, Allison Cucalon, Cecilia D. Dyer, M. Betina Pampena, James J. Knox, Regina C. LaRocque, Richelle C. Charles, Dan Li, Maya Kim, Abigail Sheridan, Nadia Storm, Rebecca I. Johnson, Jared Feldman, Blake M. Hauser, Vanessa Contreras, Romain Marlin, Raphaël Ho Tsong Fang, Catherine Chapon, Sylvie van der Werf, Eric Zinn, Aisling Ryan, Dione T. Kobayashi, Ruchi Chauhan, Marion McGlynn, Edward T. Ryan, Aaron G. Schmidt, Brian Price, Anna Honko, Anthony Griffiths, Sam Yaghmour, Robert Hodge, Michael R. Betts, Mason W. Freeman, James M. Wilson, Roger Le Grand, Luk H. Vandenberghe Cell Host and Microbe, 2021
Intranasal gene therapy to prevent infection by SARS-CoV-2 variants Joshua J. Sims, Jenny A. Greig, Kristofer T. Michalson, Sharon Lian, R. Alexander Martino, Rosemary Meggersee, Kevin B. Turner, Kalyani Nambiar, Cecilia Dyer, Christian Hinderer, Makoto Horiuchi, Hanying Yan, Xin Huang, Shu-Jen Chen, James M. Wilson Plos Pathogens, 2021
Supporting US public health experts Ron Cohen, , Cedric Francois, John Crowley, Paul Hastings, Rachel King, Ted W. Love, John Maraganore, Michelle McMurry-Heath, Jeremy Levin Nature Biotechnology, 2020
Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology Juliette Hordeaux, Elizabeth L. Buza, Cecilia Dyer, Tamara Goode, Thomas W. Mitchell, Laura Richman, Nathan Denton, Christian Hinderer, Nathan Katz, Ralf Schmid, Rod Miller, Gourav R. Choudhury, Makoto Horiuchi, Kalyani Nambiar, Hanying Yan, Mingyao Li, James M. Wilson Human Gene Therapy, 2020
The history and promise of gene therapy: A scientist's view from the front lines of basic and applied clinical research Genetic Engineering and Biotechnology News, 2011
Assessment of in vivo murine transduction efficiency and biodistribution profiles with AAV/cationic lipid Co-formulations Aiche Annual Meeting Conference Proceedings, 2008
Human cone photoreceptor dependence on RPE65 isomerase Samuel G. Jacobson, Tomas S. Aleman, Artur V. Cideciyan, Elise Heon, Marcin Golczak, et al. Proceedings of the National Academy of Sciences of the United States of America, 2007
Formulation of the anti-inflammatory cationic lipid dexamethasone-spermine with adenovirus for targeted gene delivery to the lung airway epithelia Aiche Annual Meeting Conference Proceedings, 2005
Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon β in human cancer cells Cancer Research, 2003
Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-β gene therapy is attributable to induction of systemic immunity Cancer Research, 2001
Construction of adenoviral vectors Alan R Davis, Nelson A Wivel, Joseph L Palladino, Luan Tao, James M Wilson Applied Biochemistry and Biotechnology Part B Molecular Biotechnology, 2001
Adenoviral vector-mediated GUSB cDNA transfer to treat MPS VII-affected retinal pigment epithelium Investigative Ophthalmology and Visual Science, 1997
The effect of promoter strength in adenoviral vectors containing herpes simplex virus thymidine kinase on cancer gene therapy in vitro and in vivo Cancer Gene Therapy, 1997
Gradient of RGD-dependent entry of adenoviral vector in nasal and intrapulmonary epithelia: Implications for gene therapy of cystic fibrosis Gene Therapy, 1996
Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver Gene Therapy, 1996
Complete correction of hyperbilirubinemia in the Gunn rat model of Crigler-Najjar syndrome type I following transient in vivo adenovirus-mediated expression of human bilirubin UDP-glucuronosyltransferase Gene Therapy, 1996
Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo Gene Therapy, 1996
Recombinant aoenoviral-mediatedintrapleural gene therapy for maugnant mesotheljoma: Preliminary findings of a phase I clinical trial Journal of Investigative Medicine, 1996
Retrovirus-mediated expression of HUG Br1 in Crigler-Najjar syndrome type I human fibroblasts and correction of the genetic defect in Gunn rat hepatocytes Gene Therapy, 1995
Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: A preclinical toxicology study Human Gene Therapy, 1995
Use of Recombinant Adenovirus to Transfer the Herpes Simplex Virus Thymidine Kinase (HSVtk) Gene to Thoracic Neoplasms: An Effective in Vitro Drug Sensitization System Cancer Research, 1994
Gene therapy for cystic fibrosis using el-deleted adenovirus: A phase I trial in the nasal cavity the University of North Carolina at Chapel Hill Human Gene Therapy, 1994
The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment Proceedings of the National Academy of Sciences of the United States of America, 1993
A novel mechanism for achieving transgene persistence in vivo after somatic gene transfer into hepatocytes Journal of Biological Chemistry, 1992
Role of CFTR in lysosome acidification Rebecca W. Van Dyke, Karen V. Root, James H. Schreiber, James M. Wilson Biochemical and Biophysical Research Communications, 1992
Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits Journal of Biological Chemistry, 1992
Reconstitution of tracheal grafts with a genetically modified epithelium Proceedings of the National Academy of Sciences of the United States of America, 1991
Expression of human factor IX in rat capillary endothelial cells: Toward somatic gene therapy for hemophilia B Proceedings of the National Academy of Sciences of the United States of America, 1991
An in vivo animal model of gene therapy for leukocyte adhesion deficiency Journal of Clinical Investigation, 1991
Effect of genetic transduction on in vitro canine endothelial cell prostanoid production and growth Surgical Forum, 1990
Complementation of genetic and functional defects in CD18-deficient lymphocytes by retrovirus-mediated gene transfer. Transactions of the Association of American Physicians, 1990
Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes Proceedings of the National Academy of Sciences of the United States of America, 1990
Long-term expression of human parathyroid hormone in rats after gene transfer into syngeneic fibroblasts: A model for osteoclast-mediated bone resorption Calcium Regulation and Bone Metabolism Basic and Clinical Aspects Proceedings of the 10th International Conference on Calcium Regulating Hormones and Bone Metabolism Ics886, 1990
Long-term correction of genetic defect of liver function in rat by transplantation of liver cells after ultraviolet irradiation Molecular Biology and Medicine, 1989
Targeting genes: Delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo Journal of Biological Chemistry, 1989
Retrovirus-mediated transduction of adult hepatocytes J M Wilson, D M Jefferson, J R Chowdhury, P M Novikoff, D E Johnston, et al. Proceedings of the National Academy of Sciences of the United States of America, 1988
Human adenine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme Journal of Biological Chemistry, 1986
Human hypoxanthine-guanine phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRT(Munich)) isolated from a patient with gout Journal of Biological Chemistry, 1984
Human hypoxanthine-guanine phosphoribosyltransferase. Molecular abnormality in a mutant form of the enzyme (HPRT(Toronto)) Journal of Biological Chemistry, 1983
Human adenine phosphoribosyltransferase. Immunochemical quantitation and protein blot analysis of mutant forms of the enzyme Journal of Biological Chemistry, 1982
Human hypoxanthine-guanine phosphoribosyltransferase: studies of the normal and five mutant forms of the enzyme. Transactions of the American Clinical and Climatological Association, 1982
Human hypoxanthine-guanine phosphoribosyltransferase. Tryptic peptides and post-translational modification of the erythrocyte enzyme Journal of Biological Chemistry, 1982
Adenine phosphoribosyltransferase in patients with disorders of purine and pyrimidine metabolism Journal of Laboratory and Clinical Medicine, 1982
Human hypoxanthine-guanine phosphoribosyltransferase. Purification and characterization of mutant forms of the enzyme Journal of Biological Chemistry, 1981
Defective transport and other phenotypes of a periplasmic 'leaky' mutant of Escherichia coli K-12 Journal of Bacteriology, 1979
Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts. Advances in Experimental Medicine and Biology, 1979
Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts Clinical Research, 1979
AB0238 Patient-centred approach to management of inflammatory arthritis was associated with improved satisfaction of care and perceived treatment benefit L Attipoe, S Virdee, J Greenan-Barrett, D Shah, A Cotton, J Guinto, ... Annals of the Rheumatic Diseases 77, 1301 , 2018 2018 Citations: 2
An AC coupled 10 Gb/s LVDS-compatible receiver with latched data biasing in 130 nm SiGe BiCMOS B Mathieu, JJ McCue, B Dupaix, VJ Patel, S Dooley, J Wilson, ... 2017 IEEE Compound Semiconductor Integrated Circuit Symposium (CSICS), 1-4 , 2017 2017 Citations: 2
Low voltage differential signal receiver with fully integrated AC coupling and bias latching J McCue, VJ Patel, W Khalil, B Dupaix, J Wilson, SR Dooley US Patent 9,698,735 , 2017 2017 Citations: 9
Transformer winding resistance tester test probe and method JC Wilson, R Ross US Patent 9,151,788 , 2015 2015 Citations: 1
Rolling Stock Specification for an Auto-Transformer Electrification System J Wilson Railway Electrification, 9 , 2014 2014
Toward millimeter-wave DACs: Challenges and opportunities W Khalil, J Wilson, B Dupaix, S Balasubramanian, GL Creech 2012 IEEE Compound Semiconductor Integrated Circuit Symposium (CSICS), 1-4 , 2012 2012 Citations: 19
Ultimate transmission S Balasubramanian, S Boumaiza, H Sarbishaei, T Quach, P Orlando, ... IEEE Microwave Magazine 13 (1), 64-82 , 2012 2012 Citations: 71
终极传输 S Balasubramanian, S Boumaiza, H Sarbishaei, T Quach, P Orlando, ... IEEE microwave magazine, 64 , 2012 2012
Systematic analysis of interleaved digital-to-analog converters S Balasubramanian, G Creech, J Wilson, SM Yoder, JJ McCue, ... IEEE Transactions on Circuits and Systems II: Express Briefs 58 (12), 882-886 , 2011 2011 Citations: 78
Sensing and latching circuit for memory arrays J Wilson, G Hoyer US Patent 7,995,411 , 2011 2011 Citations: 4
40 GSps, 6-bit RF DAC Design Report JE Wilson 2011
Memory sensing and latching circuit J Wilson, G Hoyer US Patent 7,760,568 , 2010 2010 Citations: 2
Method for authenticating radio frequency identification JC Wilson, G Andrechak US Patent App. 12/216,456 , 2010 2010 Citations: 18
Key identification system and form fitting label and method of manufacture JC Wilson US Patent 7,587,848 , 2009 2009 Citations: 10
Input match and load tank digital calibration of an inductively degenerated CMOS LNA J Wilson, M Ismail Integration 42 (1), 3-9 , 2009 2009 Citations: 36
Aerospace composite-rotor induction motors JC Wilson, EA Erdelyi, RE Hopkins IEEE Transactions on Aerospace, 18-23 , 2007 2007 Citations: 25
Method and apparatus for performing benefit transactions using a portable intergrated circuit device B Lee, J Wilson US Patent App. 11/767,919 , 2007 2007 Citations: 6
Method and apparatus for performing benefit transactions using a portable integrated circuit device B Lee, JC Wilson US Patent 7,234,638 , 2007 2007 Citations: 43
Application of motor control centers with molded-case circuit breakers in systems with high fault capability JC Wilson, HS Robinson IEEE Transactions on Industry Applications, 66-80 , 2007 2007 Citations: 2
The chip-peak detectors for multistandard wireless receivers SB Park, JE Wilson, M Ismail IEEE Circuits and Devices Magazine 22 (6), 6-9 , 2007 2007 Citations: 75
MOST CITED SCHOLAR PUBLICATIONS
Portable electronic data storage and retreival system for group data J Wilson, B Lee US Patent App. 10/760,172 , 2005 2005 Citations: 340
A single-chip CMOS transceiver for 802.11 a/b/g wireless LANs R Ahola, A Aktas, J Wilson, KR Rao, F Jonsson, I Hyyrylainen, A Brolin, ... IEEE Journal of Solid-State Circuits 39 (12), 2250-2258 , 2004 2004 Citations: 123
Internal protection circuit for electrically driven device JR D'Entremont, HH Fraser Jr, JC Wilson US Patent 5,200,872 , 1993 1993 Citations: 90
Systematic analysis of interleaved digital-to-analog converters S Balasubramanian, G Creech, J Wilson, SM Yoder, JJ McCue, ... IEEE Transactions on Circuits and Systems II: Express Briefs 58 (12), 882-886 , 2011 2011 Citations: 78
The chip-peak detectors for multistandard wireless receivers SB Park, JE Wilson, M Ismail IEEE Circuits and Devices Magazine 22 (6), 6-9 , 2007 2007 Citations: 75
Ultimate transmission S Balasubramanian, S Boumaiza, H Sarbishaei, T Quach, P Orlando, ... IEEE Microwave Magazine 13 (1), 64-82 , 2012 2012 Citations: 71
A CMOS RF front-end for a multistandard WLAN receiver KR Rao, J Wilson, M Ismail IEEE Microwave and Wireless Components Letters 15 (5), 321-323 , 2005 2005 Citations: 56
Ground fault protector with arcing fault indicator JT Wilson, JC Wilson US Patent 3,911,323 , 1975 1975 Citations: 54
Methods and systems for improved integrated circuit functional simulation J Wilson, K Imboden, D Gold US Patent App. 10/927,810 , 2005 2005 Citations: 51
A single chip CMOS transceiver for 802.11 a/b/g WLANs R Ahola, A Aktas, J Wilson, KR Rao, F Jonsson, I Hyyrylainen, A Brolin, ... 2004 IEEE International Solid-State Circuits Conference (IEEE Cat. No … , 2004 2004 Citations: 45
Radio design in nanometer technologies M Ismail, DR de Llera González Springer , 2006 2006 Citations: 44
Method and apparatus for performing benefit transactions using a portable integrated circuit device B Lee, JC Wilson US Patent 7,234,638 , 2007 2007 Citations: 43
Input match and load tank digital calibration of an inductively degenerated CMOS LNA J Wilson, M Ismail Integration 42 (1), 3-9 , 2009 2009 Citations: 36
Method, software and device for managing patient medical records in a universal format using USB flash drive and radio telephone auto dialer and siren J Wilson US Patent App. 11/450,151 , 2007 2007 Citations: 31
Multi standard transceiver architecture for wlan A Aktas, K Rama, J Wilson US Patent App. 10/478,467 , 2004 2004 Citations: 30
Containment device for retaining semiconductor wafers L Lewis, KT Hirose, J Wilson, J Dove, M Hayden US Patent 6,193,068 , 2001 2001 Citations: 26
Aerospace composite-rotor induction motors JC Wilson, EA Erdelyi, RE Hopkins IEEE Transactions on Aerospace, 18-23 , 2007 2007 Citations: 25
End-winding leakage of high-speed alternators by three-dimensional field determination MS Sarma, JC Wilson, PJ Lawrenson, AL Jokl IEEE Transactions on Power Apparatus and Systems, 465-477 , 2007 2007 Citations: 25
Toward millimeter-wave DACs: Challenges and opportunities W Khalil, J Wilson, B Dupaix, S Balasubramanian, GL Creech 2012 IEEE Compound Semiconductor Integrated Circuit Symposium (CSICS), 1-4 , 2012 2012 Citations: 19
Method for authenticating radio frequency identification JC Wilson, G Andrechak US Patent App. 12/216,456 , 2010 2010 Citations: 18
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
A single-chip CMOS transceiver for 802.11 a/b/g wireless LANs
Portable electronic data storage and retreival system for group data