Dr. Pranesh Kumar

Scopus Publications

Metabolites involvement in the growth and spread of liver cancer
Anurag Kumar Gautam, Vipin Kumar, Archana Bharti Sonkar, Amita Singh, Deepankar Yadav, Nitin Rajan, Pranesh Kumar, Sanjay Singh, Sudipta Saha, Vijayakumar Mahalingam Rajamanickam
Liver Research, 2025
Hepatocellular carcinoma (HCC), commonly known as primary liver cancer, is a leading cause of cancer-related mortality worldwide, primarily attributed to changing lifestyles and dietary habits. HCC arises from liver cirrhosis or fibrosis, and HBV infection, resulting from protein and lipid metabolism disruptions. These metabolic alterations, recognized as a hallmark of cancer, are pivotal in the progression of chronic liver disease to HCC. Due to its asymptomatic nature in early stages, HCC is often diagnosed at advanced stages when treatment options are limited. Despite being a potentially curative option, liver transplantation remains hindered by high costs and donor scarcity, further compounded by suboptimal long-term success rates. This review examines the critical metabolites that play a part in developing HCC, focusing on their roles as possible biomarkers for disease progression and therapeutic targets. Additionally, the influence of the gut microbiome on HCC development is discussed, highlighting its interplay with metabolic pathways. Understanding the roles of metabolites and the gut microbiome in HCC progression underscores the importance of their potential use in early detection, and the development of targeted therapies, offering new avenues for improving patient outcomes. • Altered metabolic pathways in liver cancer favor aerobic glycolysis, leading to lactate accumulation and tumor growth. • Dysbiosis in the gut microbiome contributes to chronic liver disease and HCC development through inflammation and metabolic changes. • Specific metabolites act as biomarkers in HCC progression and help in patient stratification during targeted therapy. • Dysregulation of enzymes, lipids, proteins, and amino acid-related metabolites may promote inflammation, fibrosis, and oncogenic signaling pathways, impacting hepatocarcinogenesis and facilitating tumor development in the liver.
Corrigendum to “FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms” [Redox Biol. 80 (2025) 103527] (Redox Biology (2025) 80, (S2213231725000400), (10.1016/j.redox.2025.103527))
Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity
Redox Biology, 2025
Mechanistic and metabolic exploration of neohesperidin against lung cancer cell lines through ROS-mediated mitochondrial apoptosis: An in-silico and in-vitro approach
Ruchi Pandey, Khushboo Choudhary, Surendra Rajit Prasad, Pranesh Kumar, Priya Bisht, Dande Aishwarya, Pallaprolu Nikhil, Sachindra Kumar, Ramalingam Peraman, Nitesh Kumar
Toxicology and Applied Pharmacology, 2025
FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms
Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity
Redox Biology, 2025
Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger oxidative stress have been heavily implicated in the pathogenesis of chemotherapy-associated cardiomyopathy. Here, we demonstrate that fibronectin type III domain-containing protein 5 (FNDC5), the precursor protein for myokine irisin, is depleted in the hearts of human cancer patients or mice exposed to chemotherapeutics. In cardiomyocytes, restoration of FNDC5 expression was sufficient to mitigate reactive oxygen species (ROS) accumulation and apoptosis following doxorubicin exposure, effects dependent on the irisin encoding domain of FNDC5 as well as signaling via the putative irisin integrin receptor. Intriguingly, we identified two parallel signaling cascades impacted by FNDC5 in cardiomyocytes: the ROS-driven intrinsic mitochondrial apoptosis pathway and the ROS-independent Ataxia Telangiectasia and Rad3-Related Protein (ATR)/Checkpoint Kinase 1 (Chk1) pathway. In fact, FNDC5 forms a co-precipitable complex with Chk1 alluding to possible intracellular actions for this canonically membrane-associated protein. Whereas FNDC5 overexpression in murine heart was cardioprotective, introduction of FNDC5-targeted shRNA into the myocardium was sufficient to trigger Bax up-regulation, ATR/Chk1 activation, oxidative stress, cardiac fibrosis, loss of ventricular function, and compromised animal survival. The detrimental impact of FNDC5 depletion on heart function could be mitigated via treatment with a Chk1 inhibitor identifying Chk1 hyperactivity as a causative factor in cardiac disease. Though our data point to the potential clinical utility of FNDC5/irisin-targeted agents in the treatment of chemotherapy-induced cardiotoxicity, we also found significant down regulation in FNDC5 expression in the hearts of aged mice that attenuated the cardioprotective impacts of FNDC5 overexpression following doxorubicin exposure. Together our data underscore the importance of FNDC5/irisin in maintenance of cardiac health over the lifespan. • FNDC5, the precursor protein for myokine irisin, is depleted in the hearts of human cancer patients or mice exposed to chemotherapeutics. • FNDC5 functions through parallel signaling cascades in cardiomyocytes: the ROS-driven intrinsic mitochondrial pathway and the ROS-independent ATR-Chk1 pathway. • FNDC5 forms complex with Chk1 alluding to possible intracellular actions. • FNDC5 depletion on heart can be mitigated via Chk1i, identifying Chk1 hyperactivity as a causative factor in cardiac disease.
RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21
Abhishek Singh Sengar, Manish Kumar, Chetna Rai, Sreemoyee Chakraborti, Dinesh Kumar, Pranesh Kumar, Sukhes Mukherjee, Kausik Mondal, Adele Stewart, Biswanath Maity
Journal of Translational Medicine, 2024
Background Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown. Methods Utilizing in vivo gene manipulations in mice, primary murine cardiac cells, human cell lines and human patient samples we dissect the participation of a RGS6-nucleolin complex in chemotherapy-dependent cardiotoxicity. Results Here we demonstrate that RGS6 binds to a key nucleolar protein, Nucleolin, and controls its expression and activity in cardiomyocytes. In the human myocyte AC-16 cell line, induced pluripotent stem cell derived cardiomyocytes, primary murine cardiomyocytes, and the intact murine myocardium tuning RGS6 levels via overexpression or knockdown resulted in diametrically opposed impacts on Nucleolin mRNA, protein, and phosphorylation.RGS6 depletion provided marked protection against nucleolar stress-mediated cell death in vitro, and, conversely, RGS6 overexpression suppressed ribosomal RNA production, a key output of the nucleolus, and triggered death of myocytes. Importantly, overexpression of either Nucleolin or Nucleolin effector miRNA-21 counteracted the pro-apoptotic effects of RGS6. In both human and murine heart tissue, exposure to the genotoxic stressor doxorubicin was associated with an increase in the ratio of RGS6/Nucleolin. Preventing RGS6 induction via introduction of RGS6-directed shRNA via intracardiac injection proved cardioprotective in mice and was accompanied by restored Nucleolin/miRNA-21 expression, decreased nucleolar stress, and decreased expression of pro-apoptotic, hypertrophy, and oxidative stress markers in heart. Conclusion Together, these data implicate RGS6 as a driver of nucleolar stress-dependent cell death in cardiomyocytes via its ability to modulate Nucleolin. This work represents the first demonstration of a functional role for an RGS protein in the nucleolus and identifies the RGS6/Nucleolin interaction as a possible new therapeutic target in the prevention of cardiotoxicity.
Preclinical evaluation of dalbergin loaded PLGA-galactose-modified nanoparticles against hepatocellular carcinoma via inhibition of the AKT/NF-κB signaling pathway
Anurag Kumar Gautam, Pranesh Kumar, Vipin Kumar, Amita Singh, Tarun Mahata, Biswanath Maity, Sachin Yadav, Dinesh Kumar, Sanjay Singh, Sudipta Saha, M.R. Vijayakumar
International Immunopharmacology, 2024
Appraisal of folate functionalized bosutinib cubosomes against hepatic cancer cells: In-vitro, In-silico, and in-vivo pharmacokinetic study
Raquibun Nisha, Pranesh Kumar, Nidhi Mishra, Priyanka Maurya, Shakir Ahmad, Neelu Singh, Shubhini A. Saraf
International Journal of Pharmaceutics, 2024
Novel bioinspired dinuclear Cu(II) ‘paddle wheel’ acetate complex: Catalytic and in vitro biological activity studies
Sahin Reja, Kaushik Sarkar, Deboshmita Mukherjee, Shramana Guha, Supriyo Ghosh, Tilak Saha, Pranesh Kumar, Purak Das, Rajesh Kumar Das
Journal of Molecular Structure, 2024
A Comprehensive Review on Exosome: Recent Progress and Outlook
Paras Agarwal, Adiba Anees, Raval Kavit Harsiddharay, Pranesh Kumar, Pushpendra Kumar Tripathi
Pharmaceutical Nanotechnology, 2024
Exosomes are intrinsic membrane-based vesicles that play a key role in both normal and pathological processes. Since their discovery, exosomes have been investigated as viable drug delivery systems and clinical indicators because of their magnitude and effectiveness in delivering biological components to targeted cells. Exosome characteristics are biocompatible, prefer tumor recruitment, have tunable targeting efficiency, and are stable, making them outstanding and eye-catching medication delivery systems for cancer and other disorders. There is great interest in using cell-released tiny vesicles that activate the immune system in the age of the fast development of cancer immunotherapy. Exosomes, which are cell-derived nanovesicles, have a lot of potential for application in cancer immunotherapy due to their immunogenicity and molecular transfer function. More significantly, exosomes can transfer their cargo to specified cells and so affect the phenotypic and immune-regulation capabilities of those cells. In this article, we summarize exosomes' biogenesis, isolation techniques, drug delivery, applications, and recent clinical updates. The use of exosomes as drug-delivery systems for small compounds, macromolecules, and nucleotides has recently advanced. We have tried to give holistic and exhaustive pieces of information showcasing current progress and clinical updates of exosomes.
Targeting caspase pathway by novel N-Me aziridine derivatives for hepatocellular carcinoma drug discovery
Pranesh Kumar, Tabrez Faruqui, Ajay K. Yadav, Dinesh Chandra, Saumya Verma, Sudipta Saha, Jawahar L. Jat, Yusuf Akhter
Journal of Biomolecular Structure and Dynamics, 2024
Azaheterocycles are three-membered rings, known as aziridines, that occur naturally and have pharmaceutical applications.These compounds are present as several secondary metabolites produced by plants and microorganisms.Recent studies have demonstrated the effectiveness of aziridine derivatives (N-H/N-Me) as anticancer agents.We synthesized 18 compounds containing an N-Me enone aziridine group, the chemistry of which has been previously published. However, these compounds have drug-likeness properties; therefore, we aimed to demonstrate their drug-like properties using in silico and in vitro investigations.The molecular structures of the compounds were optimized using density functional theory (DFT). The ADMET parameters of the derivatives were calculated using SwissADME and PreADMET. Additionally, these derivatives were evaluated for their ability to bind to caspase-3 and caspase-9 and then subjected to molecular docking. The lead chemical AY128 maintained stable complexes with target proteins during molecular dynamics simulations, as evidenced by the root mean square deviation (RMSD) and root mean square fluctuation (RMSF) parameters. In vitro cytotoxicity and ELISA tests showed that the novel aziridine derivatives, especially AY128, had strong anticancer activity against HepG2 hepatocellular carcinoma cells.Our study suggests that AY128 may be a potential drug candidate for hepatocellular carcinoma through the caspase-3 and caspase-9-dependent apoptotic pathways.Communicated by Ramaswamy H. Sarma.
RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation
Madhuri Basak, Kiran Das, Tarun Mahata, Dinesh Kumar, Nupur Nagar, Krishna Mohan Poluri, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Cellular and Molecular Life Sciences, 2023
Cardiac RGS7 and RGS11 drive TGFβ1-dependent liver damage following chemotherapy exposure
Kiran Das, Madhuri Basak, Tarun Mahata, Sayan Biswas, Sukhes Mukherjee, Pranesh Kumar, Mahammed Moniruzzaman, Adele Stewart, Biswanath Maity
FASEB Journal, 2023
Vinpocetine mitigates DMH-induce pre-neoplastic colon damage in rats through inhibition of pro-inflammatory cytokines
Archana Bharti Sonkar, Pranesh Kumar, Anand Kumar, Anurag Kumar Gautam, Abhishek Verma, Amita Singh, Umesh Kumar, Dinesh Kumar, Tarun Mahata, Bolay Bhattacharya, Amit K. Keshari, Biswanath Maity, Sudipta Saha
International Immunopharmacology, 2023
3, 3′-[succinylbis(diazaneyl)]bis(N,N,N-trimethylpropan-1-ammonium) perchlorate: Synthesis, characterization, computational studies and in vitro anticancer activity against the human colon carcinoma cell line (HT-29)
Sahin Reja, Kaushik Sarkar, Deboshmita Mukherjee, T.K.S. Fayaz, Pranesh Kumar, Purak Das, Palash Sanphui, Rajesh Kumar Das
Journal of Molecular Structure, 2023
A RGS7-CaMKII complex drives myocyte-intrinsic and myocyteextrinsic mechanisms of chemotherapy-induced cardiotoxicity
Madhuri Basak, Abhishek Singh Sengar, Kiran Das, Tarun Mahata, Manish Kumar, Dinesh Kumar, Sayan Biswas, Subhasish Sarkar, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Proceedings of the National Academy of Sciences of the United States of America, 2023
A Comprehensive Review on PCSK9 as Mechanistic Target Approach in Cancer Therapy
Sudipta Saha, Amita Singh, Pranesh Kumar, Archana Bharti Sonkar, Anurag Kumar Gautam, Abhishek Verma, Biswanath Maity, Himani Tiwari, Nanda Gopal Sahoo, Amit K. Keshari, S.K. Yadav
Mini Reviews in Medicinal Chemistry, 2023
In vitro cytotoxicity activity of copper complexes of imine and amine ligands: A combined experimental and computational study
Deboshmita Mukherjee, Sahin Reja, Kaushik Sarkar, T.K.S. Fayaz, Pranesh Kumar, Ambica Kejriwal, Purak Das, Palash Sanphui, Rajesh Kumar Das
Inorganic Chemistry Communications, 2022
RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis
Kiran Das, Madhuri Basak, Tarun Mahata, Manish Kumar, Dinesh Kumar, Sayan Biswas, Suvro Chatterjee, Mahammed Moniruzzaman, Nimai Chandra Saha, Kausik Mondal, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Redox Biology, 2022
Synthesis and appraisal of dalbergin-loaded PLGA nanoparticles modified with galactose against hepatocellular carcinoma: In-vitro, pharmacokinetic, and in-silico studies
Anurag Kumar Gautam, Pranesh Kumar, Biswanath Maity, Ganesh Routholla, Balaram Ghosh, Kumarappan Chidambaram, M. Yasmin Begum, Adel Al Fatease, P.S. Rajinikanth, Sanjay Singh, Sudipta Saha, Vijayakumar M. R.
Frontiers in Pharmacology, 2022
Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma
Raquibun Nisha, Pranesh Kumar, Umesh Kumar, Nidhi Mishra, Priyanka Maurya, Priya Singh, Heena Tabassum, Alka, Samipta Singh, Anupam Guleria, Shubhini A. Saraf
International Journal of Pharmaceutics, 2022
New Scope of Targeted Therapies in Lung Carcinoma
Archana Sonkar, Pranesh Kumar, Anurag Gautam, Biswanath Maity, Sudipta Saha
Mini Reviews in Medicinal Chemistry, 2022
Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway
Anurag Kumar Gautam, Pranesh Kumar, Ritu Raj, Dinesh Kumar, Bolay Bhattacharya, P.S. Rajinikanth, Kumarappan Chidambaram, Tarun Mahata, Biswanath Maity, Sudipta Saha
Frontiers in Pharmacology, 2022
Appraisal of anti-gout potential of colchicine-loaded chitosan nanoparticle gel in uric acid-induced gout animal model
Poonam Parashar, Ifrah Mazhar, Jovita Kanoujia, Abhishek Yadav, Pranesh Kumar, Shubhini A. Saraf, Sudipta Saha
Archives of Physiology and Biochemistry, 2022
Mechanistic exploration of the activities of poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid against hepatocellular carcinoma at cellular and molecular levels
Pranesh Kumar, Anurag Kumar Gautam, Umesh Kumar, Archana S. Bhadauria, Ashok K. Singh, Dinesh Kumar, Tarun Mahata, Biswanath Maity, Hriday Bera, Sudipta Saha
Archives of Physiology and Biochemistry, 2022
Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction at the cellular, molecular and metabolic levels
Pranesh Kumar, Mohit Kumar, Anurag Kumar Gautam, Archana Bharti Sonkar, Abhishek Verma, Amita Singh, Raquibun Nisha, Umesh Kumar, Dinesh Kumar, Tarun Mahata, Bolay Bhattacharya, Biswanath Maity, Abhishek Pandeya, Sunil Babu Gosipatala, Sudipta Saha
Bba Advances, 2022
3-(1,3-Dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate: Synthesis, crystal structure, docking study and in vitro anticancer activity against the human hepatomas cell line (Hep G2)
Sahin Reja, Deboshmita Mukherjee, Purak Das, Pranesh Kumar, Rajesh Kumar Das
Journal of Molecular Structure, 2021
G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity
Arnab Pramanick, Sreemoyee Chakraborti, Tarun Mahata, Madhuri Basak, Kiran Das, Sumit Kumar Verma, Abhishek Singh Sengar, Praveen Kumar Singh, Pranesh Kumar, Bolay Bhattacharya, Sayan Biswas, Parag Baran Pal, Subhasish Sarkar, Vinita Agrawal, Sudipta Saha, Debjani Nath, Suvro Chatterjee, Adele Stewart, Biswanath Maity
Redox Biology, 2021
Fabrication of Imatinib Mesylate-Loaded Lactoferrin-Modified PEGylated Liquid Crystalline Nanoparticles for Mitochondrial-Dependent Apoptosis in Hepatocellular Carcinoma
Raquibun Nisha, Pranesh Kumar, Umesh Kumar, Nidhi Mishra, Priyanka Maurya, Samipta Singh, Priya Singh, Anupam Guleria, Sudipta Saha, Shubhini A Saraf
Molecular Pharmaceutics, 2021
Dextran-based nanomaterials in drug delivery applications
Siddhartha Maity, Sudipta Saha, Srimanta Sarkar, Pranesh Kumar, Anurag Kumar Gautam, Archana Bharti Sonkar
Biopolymer Based Nanomaterials in Drug Delivery and Biomedical Applications, 2021
Gelatin-based nanomaterials in drug delivery and biomedical applications
Poonam Parashar, Pranesh Kumar, Anurag Kumar Gautam, Neelu Singh, Hriday Bera, Srimanta Sarkar, Shubhini A. Saraf, Sudipta Saha
Biopolymer Based Nanomaterials in Drug Delivery and Biomedical Applications, 2021
Author Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals (Scientific Reports, (2018), 8, 1, (5932), 10.1038/s41598-018-24288-0)
Ashok K. Singh, Archana S. Bhadauria, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Amit K. Keshari, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Sudipta Saha
Scientific Reports, 2020
Malabaricone C attenuates nonsteroidal anti-inflammatory drug-induced gastric ulceration by decreasing oxidative/nitrative stress and inflammation and promoting angiogenic autohealing
Madhuri Basak, Tarun Mahata, Sreemoyee Chakraborti, Pranesh Kumar, Bolay Bhattacharya, Sandip Kumar Bandyopadhyay, Madhusudan Das, Adele Stewart, Sudipta Saha, Biswanath Maity
Antioxidants and Redox Signaling, 2020
Assessments of in vitro and in vivo antineoplastic potentials of β-sitosterol-loaded PEGylated niosomes against hepatocellular carcinoma
Raquibun Nisha, Pranesh Kumar, Anurag Kumar Gautam, Hriday Bera, Bolay Bhattacharya, Poonam Parashar, Shubhini A. Saraf, Sudipta Saha
Journal of Liposome Research, 2020
Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis
Pranesh Kumar, Aakriti Agarwal, Ashok K. Singh, Anurag Kumar Gautam, Sreemoyee Chakraborti, Umesh Kumar, Dinesh Kumar, Bolay Bhattacharya, Parthasarathi Panda, Biswajit Saha, Tabish Qidwai, Biswanath Maity, Sudipta Saha
Regulatory Toxicology and Pharmacology, 2019
Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis
Vimal Maurya, Pranesh Kumar, Sreemoyee Chakraborti, Ashok K. Singh, Archana S. Bhadauria, Umesh Kumar, Dinesh Kumar, Arnab Pramanik, Biswajit Saha, Venkatesh Kumar R, Sunil Babu Gosipatala, Bolay Bhattachariya, Biswanath Maity, Sudipta Saha
Chemico Biological Interactions, 2019
Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling
Vinit Raj, Archana S. Bhadauria, Ashok K. Singh, Umesh Kumar, Amit Rai, Amit K. Keshari, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Kausar M. Ansari, Jawahar L. Jat, Sudipta Saha
Cytokine, 2019
Bioactive and drug-delivery potentials of polysaccharides and their derivatives
Ashok K. Singh, Archana S. Bhadauria, Pranesh Kumar, Hriday Bera, Sudipta Saha
Polysaccharide Carriers for Drug Delivery, 2019
Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
Ashok K. Singh, Archana S. Bhadauria, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Amit K. Keshari, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Sudipta Saha
Scientific Reports, 2018
Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
Pranesh Kumar, Archana S. Bhadauria, Ashok K. Singh, Sudipta Saha
Life Sciences, 2018
Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer
Amit Rai, Umesh Kumar, Vinit Raj, Ashok K Singh, Pranesh Kumar, Amit K Keshari, Dinesh Kumar, Biswanath Maity, Arnab De, Amalesh Samanta, Sneha Nath, Anand Prakash, Sunil Babu Gosipatala, Gyan Chand, Sudipta Saha
Pharmacological Research, 2018
ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation
Chandra Bhushan Tripathi, Neha Gupta, Pranesh Kumar, Ashok Kumar Singh, Vinit Raj, Poonam Parashar, Mahendra Singh, Jovita Kanoujia, Malti Arya, Shubhini A Saraf, Sudipta Saha
AAPS Pharmscitech, 2018
6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals
Priyanka Mishra, Vinit Raj, Archana S. Bhadauria, Ashok K Singh, Amit Rai, Pranesh Kumar, Amit K Keshari, Arnab De, Amalesh Samanta, Umesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Kausar M. Ansari, Sudipta Saha
Biomedicine and Pharmacotherapy, 2018
Poly(Lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: Characterization, in vitro and in vivo evaluations
Pranesh Kumar, Ashok K Singh, Vinit Raj, Amit Rai, Amit K Keshari, Dinesh Kumar, Biswanath Maity, Anand Prakash, Sabyasachi Maiti, Sudipta Saha
International Journal of Nanomedicine, 2018
Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation
Ashok K. Singh, Vinit Raj, Amit K. Keshari, Amit Rai, Pranesh Kumar, Atul Rawat, Biswanath Maity, Dinesh Kumar, Anand Prakash, Arnab De, Amalesh Samanta, Bolay Bhattacharya, Sudipta Saha
Chemico Biological Interactions, 2018
5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction
Amit K Keshari, Ashok K Singh, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Sudipta Saha
Drug Design Development and Therapy, 2017
Protective effect of naringin against pylorus ligation-induced esophagitis in male wistar rats
C Shalini, P Kumar, K A. Singh, R Vinit, R Amit, K K. Amit, A Prakash, S Saha
Indian Journal of Pharmaceutical Sciences, 2017
Determination of 5H-benzo[2,3][1,4]oxazepino[5,6-B]indoles in rat plasma by reversed-phase high-performance liquid chromatographic-ultraviolet method: Application to pharmacokinetic STUDIES
Ashok K Singh, Vinit Raj, Amit Rai, Amit K Keshari, Pranesh Kumar, Sudipta Saha
Asian Journal of Pharmaceutical and Clinical Research, 2017
6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates heptatocellular carcinoma in rats with NMR-based metabolic perturbations
Pranesh Kumar, Ashok K Singh, Vinit Raj, Amit Rai, Siddhartha Maity, Atul Rawat, Umesh Kumar, Dinesh Kumar, Anand Prakash, Anupam Guleria, Sudipta Saha
Future Science Oa, 2017
Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats
Amit K. Keshari, Ghanendra Kumar, Priya S. Kushwaha, Monika Bhardwaj, Pranesh Kumar, Atul Rawat, Dinesh Kumar, Anand Prakash, Balaram Ghosh, Sudipta Saha
Journal of Ethnopharmacology, 2016
Antiproliferative effect of isolated isoquinoline alkaloid from Mucuna pruriens seeds in hepatic carcinoma cells
Pranesh Kumar, Atul Rawat, Amit K. Keshari, Ashok K. Singh, Siddhartha Maity, Arnab De, Amalesh Samanta, Sudipta Saha
Natural Product Research, 2016

MOST CITED SCHOLAR PUBLICATIONS

Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats
AK Keshari, G Kumar, PS Kushwaha, M Bhardwaj, P Kumar, A Rawat, ...
Journal of ethnopharmacology 181, 252-262 , 2016
2016
Citations: 121
Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation
AK Singh, V Raj, AK Keshari, A Rai, P Kumar, A Rawat, B Maity, D Kumar, ...
Chemico-Biological Interactions 280, 33-44 , 2018
2018
Citations: 116
Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
P Kumar, AS Bhadauria, AK Singh, S Saha
Life sciences 209, 24-33 , 2018
2018
Citations: 77
Poly(lactic- co -glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: characterization, in vitro and in vivo evaluations
P Kumar, AK Singh, V Raj, A Rai, AK Keshari, D Kumar, B Maity, ...
International journal of nanomedicine, 975-990 , 2018
2018
Citations: 59
Novel 1, 3, 4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling
V Raj, AS Bhadauria, AK Singh, U Kumar, A Rai, AK Keshari, P Kumar, ...
Cytokine 118, 144-159 , 2019
2019
Citations: 57
Antiproliferative effect of isolated isoquinoline alkaloid from Mucuna pruriens seeds in hepatic carcinoma cells
P Kumar, A Rawat, AK Keshari, AK Singh, S Maity, A De, A Samanta, ...
Natural product research 30 (4), 460-463 , 2016
2016
Citations: 38
Assessments of in vitro and in vivo antineoplastic potentials of β-sitosterol-loaded PEGylated niosomes against hepatocellular carcinoma
R Nisha, P Kumar, AK Gautam, H Bera, B Bhattacharya, P Parashar, ...
Journal of Liposome Research 31 (3), 304-315 , 2020
2020
Citations: 36
Bioactive and drug-delivery potentials of polysaccharides and their derivatives
AK Singh, AS Bhadauria, P Kumar, H Bera, S Saha
Polysaccharide carriers for drug delivery, 19-48 , 2019
2019
Citations: 31
Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
AK Singh, AS Bhadauria, U Kumar, V Raj, A Rai, P Kumar, AK Keshari, ...
Scientific reports 8 (1), 5932 , 2018
2018
Citations: 31
Appraisal of anti-gout potential of colchicine-loaded chitosan nanoparticle gel in uric acid-induced gout animal model
P Parashar, I Mazhar, J Kanoujia, A Yadav, P Kumar, SA Saraf, S Saha
Archives of Physiology and Biochemistry 128 (2), 547-557 , 2022
2022
Citations: 30
Murrayanine-chalcone transformed into novel pyrimidine compounds demonstrated promising anti-inflammatory activity
DK Mahapatra, RS Shivhare, P Kumar
Asian J Pharm Res 8 (1), 6-10 , 2018
2018
Citations: 28
5H-benzo [h] thiazolo [2, 3-b] quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress …
AK Keshari, AK Singh, U Kumar, V Raj, A Rai, P Kumar, D Kumar, B Maity, ...
Drug design, development and therapy, 2981-2995 , 2017
2017
Citations: 28
In silico study of some dexamethasone analogs and derivatives against SARs-CoV-2 target: A cost-effective alternative to remdesivir for various COVID phases
R Pandey, I Dubey, I Ahmad, DK Mahapatra, H Patel, P Kumar
Current Chinese Science 2 (4), 294-309 , 2022
2022
Citations: 27
Fabrication of imatinib mesylate-loaded lactoferrin-modified PEGylated liquid crystalline nanoparticles for mitochondrial-dependent apoptosis in hepatocellular carcinoma
R Nisha, P Kumar, U Kumar, N Mishra, P Maurya, S Singh, P Singh, ...
Molecular pharmaceutics 18 (3), 1102-1120 , 2020
2020
Citations: 27
Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma
R Nisha, P Kumar, U Kumar, N Mishra, P Maurya, P Singh, H Tabassum, ...
International Journal of Pharmaceutics 622, 121848 , 2022
2022
Citations: 26
Gelatin-based nanomaterials in drug delivery and biomedical applications
P Parashar, P Kumar, AK Gautam, N Singh, H Bera, S Sarkar, SA Saraf, ...
Biopolymer-based nanomaterials in drug delivery and biomedical applications … , 2021
2021
Citations: 23
Novel 1, 4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer
A Rai, U Kumar, V Raj, AK Singh, P Kumar, AK Keshari, D Kumar, B Maity, ...
Pharmacological Research 132, 188-203 , 2018
2018
Citations: 22
A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity
M Basak, AS Sengar, K Das, T Mahata, M Kumar, D Kumar, S Biswas, ...
Proceedings of the National Academy of Sciences 120 (1), e2213537120 , 2023
2023
Citations: 21
6, 7-dimethoxy-1, 2, 3, 4-tetrahydro-isoquinoline-3-carboxylic acid attenuates heptatocellular carcinoma in rats with NMR-based metabolic perturbations
P Kumar, AK Singh, V Raj, A Rai, S Maity, A Rawat, U Kumar, D Kumar, ...
Future science oa 3 (3), FSO202 , 2017
2017
Citations: 21
Malabaricone C attenuates nonsteroidal anti-inflammatory drug-induced gastric ulceration by decreasing oxidative/nitrative stress and inflammation and promoting angiogenic …
M Basak, T Mahata, S Chakraborti, P Kumar, B Bhattacharya, ...
Antioxidants & redox signaling 32 (11), 766-784 , 2020
2020
Citations: 20

Dr. Pranesh Kumar

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