NANDAkumar K

Scopus Publications

Burrowing behavior is a potential non-invasive proxy for lesion development in a syngeneic murine model of endometriosis
Megha Anchan, Samruddhi Deshpande, Atharvaraj Hande, Rooma Sinha, Jayesh Mudgal, K. Nandakumar, Rahul Dutta
BMC Women S Health, 2026
Background Endometriosis (EM) is a persistent, chronic inflammatory condition associated with excruciating pelvic pain and infertility. The absence of a pre-clinical model that reliably replicates the clinical and functional hallmarks of human EM continues to limit progress in the domain. Furthermore, no rodent model developed to date has achieved a 100% incidence rate, compromising the reproducibility of existing models. Further, the inability to detect lesion development without sacrificing the animal presents a significant barrier for preclinical interventional trials designed to improve the management of EM. Methods We employed a non-invasive method based on the altered burrowing behavior of the animal to predict lesion development in the syngeneic mice EM model. We used the burrowing assay (BA) before dissection as a non-invasive behavioral marker to evaluate lesion progression across three distinct laboratory strains: C57BL/6j, BALB/c, and Swiss albino to account for variation due to genetic, immunological, and strain specificity. Results EM mice displayed a significant decline in burrowing activity compared to controls across all three strains. Based on BA performance, recipient mice were stratified into two groups: Recipients with a low burrow score (LB) and those with a high burrow score (HB). Additionally, LB mice exhibited decreased exploratory behavior and increased sensitivity to thermal pain. In contrast, HB mice had exploratory and thermal responses comparable to those of the control group. Post-dissection, LB mice were presented with ectopic lesions (LB+), whereas HB mice were lesion-negative (HB-). BA performance correlated strongly with lesion presence via ROC analysis, with a combined AUC of 0.883 (and an AUC of 1 for C57BL/6j), indicating excellent diagnostic accuracy of BA in predicting EM incidence. The combined approach of correlating burrowing behavior with other evoked behavioral responses and non-evoked provided a comprehensive assessment of EM disease progression. Conclusion To our knowledge, our research provides evidence for the feasibility of ethologically valid burrowing behaviour as a non-invasive predictor of EM incidence in the syngeneic mice model. Future preclinical drug research for EM management could leverage BA to identify and select only lesion-positive animals for intervention trials. This approach will enhance the translational value of EM research.
Insights into effective protocol structuring: optimizing dosing strategies, experimental design, and statistical approaches
Pitchai Balakumar, Krishnadas Nandakumar, Gowraganahalli Jagadeesh
Pharmacology and Therapeutics, 2026
Computational identification of marine-derived inhibitors of Cyclophilin D and Protease-Activated Receptor-1 for the treatment of ischemic disease
Veeresh Sadashivanavar, Manjunath Madalageri, Raghavendra Kinnal, Krishnadas Nandakumar, Ruchi Verma, K Sreedhara Ranganath Pai
Journal of Molecular Graphics and Modelling, 2026
Myocardial infarction (MI) and stroke are examples of ischaemic diseases that continue to pose serious health risks since few specific treatments address the underlying molecular causes of these conditions, which include pathological thrombosis and mitochondrial dysfunction. In order to close this gap, we used an integrated in-silico method to find strong inhibitors for Protease-Activated Receptor-1 (PAR-1) and Cyclophilin D (CypD) from the structurally diverse CMNPD marine natural product library. To account for protein flexibility, our method combines High Throughput Virtual Screening (HTVS), Standard Precision (SP), and Extra Precision (XP) docking with meticulous Induced Fit Docking (IFD). After undergoing 500 ns Molecular Dynamics (MD) simulations, the best candidate compounds showed remarkable structural stability with RMSD values between 0.6 and 1.7 Å. Strong binding affinities were found by thermal MM-GBSA calculations, with CMNPD29955 showing a ΔG of –63.146 kcal/mol towards CypD and CMNPD3572 and CMNPD22037 showing ΔG values of –96.24 and –98.092 kcal/mol against PAR-1, respectively. Lead molecules of each target were found to have important hydrophobic and hydrogen bonding interactions with crucial active site residues in MD modelling. The dynamic stability and energetic favorability of these chemicals were further confirmed by complementary techniques, including WaterMap, Principal Component Analysis (PCA), and Free Energy Landscape (FEL). In addition to CMNPD3572 and CMNPD22037 as potential PAR-1 antagonists, this work emphasises CMNPD29955 as a new lead inhibitor that targets mitochondrial dysfunction via CypD. To transform computational insights into effective and complementary therapeutic alternatives, lead optimisation, experimental validation, and preclinical assessment of these special marine-derived molecules will be crucial in the future. • By focusing on thrombosis (Protease-Activated Receptor-1 (PAR-1)) and mitochondrial dysfunction (Cyclophilin D (CypD)), an integrated multi-stage in-silico workflow was used to find new treatments for ischemic diseases. • Lead compounds demonstrated excellent dynamic stability during 500 ns molecular dynamics simulations, with RMSD values consistently between 0.6 and 1.7 Å. • MM-GBSA binding free energy calculations revealed strong affinities, including CMNPD3572 and CMNPD22037 for PAR-1 (ΔG ≈ -96 to -98 kcal/mol) and CMNPD29955 for CypD (ΔG ≈ −63 kcal/mol). • Further advanced analyses, such as WaterMap, PCA and Free Energy Landscape studies, confirmed favorable hydration thermodynamics along with stable conformational dynamics and energetically preferred binding states. • CMNPD29955 emerged as a novel marine-derived CypD inhibitor. CMNPD3572 and CMNPD22037 are as PAR-1 inhibitors highlighting a promising strategy to mitigate mitochondrial dysfunction alongside PAR-1–mediated thrombosis in ischemic disorders.
Reversal of diabetes-associated cognitive impairment through modulation of BDNF, insulin, and NF-κB pathways by a marketed herbal formulation
Nabeel Kinattingal, Venugopal Bovilla, Seema Mehdi, Mahadevaswamy G. Kuruburu, K. Nandakumar, Santhepete N. Manjula
3 Biotech, 2026
Diabetes-associated cognitive impairment is a recognized complication of chronic hyperglycemia affecting learning and memory. We investigated whether Tamarindus indica seed extract (TSE) and Diabecon, a marketed herbal formulation (MHF), could reverse diabetes-associated cognitive decline in a high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rat model. Diabetic rats were treated with pioglitazone (standard), TSE (250 mg/kg), or MHF (500 mg/kg) for four weeks. Antioxidant activity and phenolic content of TSE and MHF were evaluated using DPPH radical scavenging and ferric-reducing antioxidant power (FRAP) assays, and animals were assessed for learning and memory using the Barnes maze and novel object recognition tests. Hippocampal biochemical analysis revealed reduced antioxidant levels, decreased BDNF and insulin levels, and increased oxidative stress and inflammatory cytokines in diabetic rats. Behavioral assessments demonstrated significant cognitive impairment in HFD–STZ diabetic rats, evidenced by increased escape latency time and reduced preference index. Treatment with MHF significantly improved cognitive performance compared with untreated diabetic animals, whereas TSE showed limited effects. Biochemical analysis revealed that diabetes induction reduced hippocampal BDNF and insulin levels and increased oxidative stress and inflammatory cytokines. MHF treatment significantly restored BDNF and insulin levels, reduced lipid peroxidation, enhanced endogenous antioxidant enzyme activity, and suppressed inflammatory mediators. Western blot analysis further demonstrated modulation of NF-κB and Nrf2 signaling pathways in the hippocampus following MHF treatment. These findings suggest that the marketed herbal formulation Diabecon may alleviate diabetes-associated cognitive decline by reducing oxidative stress and inflammation while improving neurotrophic signaling.
Preclinical evidence for digoxin's anti-tumor activity through HIF-1α pathways: Systematic review and meta-analysis
Dhanya Bolar, Gollapalle Lakshminarayanashastry Viswanatha, Chamallamudi Mallikarjuna Rao, Shylaja Hanumanthappa, Krishnadas Nandakumar, Pawan Ganesh Nayak
Pharmacological Research Natural Products, 2026
This systematic review and meta-analysis was aimed to synthesize existing preclinical evidence on digoxin's anti-tumor effects via HIF-1α inhibition. This study was conducted as per PRISMA 2020 guidelines. A systematic literature search was conducted using PubMed/Medline, EMBASE, and Google Scholar, and based on the inclusion and exclusion criteria, a total of 13 studies were selected. The meta-analysis performed on the included studies revealed that the digoxin treatment decreased the tumor volume (IV:-1.40(-1.89 to -0.91) at 95% CI, p<0.00001, I 2 =42%), H I F-1α (IV:-2.43(-4.07 to -0.78) at 95% CI, p=0.004, I 2 = 62%), VEGF (IV:-1.14(-1.91 to -0.36) at 95% CI, p=0.004, I 2 = 0%), and GLUT-1 (IV: 1.57(-2.57 to -0.57) at 95% CI, p=0.002 I 2 = 0%), but had no statistically significant reduction in the tumor weight (IV:-0.31(-0.69 to 0.07), 95% CI, p=0.11, I 2 =98%), and CD31 marker (IV:-1.15(-3.10 to 0.79) at 95% CI, p=0.25, I 2 =71%) and has no effect on the animal survival rate (IV:6.46(-0.93 to 13.86) at 95% CI, p=0.09, I 2 =86%) compared to the control. Conclusions: In summary, the available moderate weight of evidence suggests that digoxin possesses potential anti-tumor effects via HIF-1α pathways. However, considering the pitfalls associated with the existing studies, there is a scope for conducting more robust pre-clinical studies. Further, randomized controlled trials in humans are essential to evaluate and validate the antitumor effect of digoxin. • Meta-analysis shows digoxin reduces tumor growth in preclinical models • Digoxin targets hypoxia inducible factor (HIF-1α) driving tumor growth pathways • Associated with reduced tumor size and key signals linked to growth • No consistent effect on survival or tumor weight across studies • Further preclinical studies and human trials are needed for validation
Gemini surfactant-stabilized cubosomes for enhanced topical delivery of 5-fluorouracil in cutaneous squamous cell carcinoma
Ruchira Raychaudhuri, Ajinkya Nitin Nikam, Naitik Jain, Abhisheik Eedara, Neha Kandpal, Rajdeep Ray, Krishnadas Nandakumar, Sai Balaji Andugulapati, Srinivas Mutalik
International Journal of Pharmaceutics X, 2026
Cutaneous squamous cell carcinoma (cSCC) is a prevalent non-melanoma skin cancer. Topical chemotherapy offers a non-invasive alternative to surgical treatments, yet the therapeutic efficacy of conventional agents like 5-fluorouracil is hindered by poor skin permeability and systemic side effects. In this study, we developed a gemini-surfactant-stabilized cubosomal gel (OF12-GEL) for enhanced topical delivery of 5-fluorouracil. The optimized cubosomes (OF12) exhibited a particle size of 134.4 nm, PDI 0.23, zeta potential +76.1 mV, and 51.3% entrapment efficiency. OF12-GEL achieved 41% release at 24 h and increased skin deposition to 323.7 μg/cm 2 , nearly 3-fold higher than free 5-FU (114.1 μg/cm 2 ). In A431 cells, OF12 showed a lower IC₅₀ (0.77 μg/mL) than free 5-FU (1.15 μg/mL) and enhanced cellular uptake. In vivo , OF12-GEL significantly suppressed tumor growth in both DMBA-induced SCC rats and A431 xenograft mice, reducing tumor volume by and improving survival to 60%, and markedly downregulating BCL-2, Ki67, TNF-α, and ABCB1. OF12-GEL was non-irritant (PII = 0.33). These findings demonstrate a potent, safe, and targeted nanocarrier-based topical therapy for cSCC.
In Vitro Reaction Phenotyping and Projection of Drug Interactions Mediated by Cytochrome P450 Enzymes for Central Nervous System Drugs as Victims: Implications for Safety in Vulnerable Populations
Veera Raghava Chowdary Palacharla, Ramakrishna Nirogi, Nitesh Kumar, Pradeep Jayarajan, Hanumanth Rao Pantangi, Surendra Petlu, Krishnadas Nandakumar
Drug Metabolism and Disposition, 2026
Reverse Phase High Performance Liquid Chromatography Method for the Estimation of Mangiferin in Nano Formulations: Development and Optimization by Analytical Quality-by-Design
Akshatha P. Kamath, Lalit Kumar, Srinivas Mutalik, Pawan Ganesh Nayak, Krishnadas Nandakumar
ACS Omega, 2026
A novel reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and optimized for the estimation of Mangiferin (MGF) by employing a Quality by Design (QbD) approach. Preliminary method screening was done by the Taguchi OA, followed by using a Box-Behnken Design (BBD), enabling systematic evaluation of critical factors with a reduced number of experimental runs. The model efficiently established significant correlations between selected variables and analytical responses, thereby enhancing the method's robustness and reliability. Chromatographic separation was achieved on a Hyperclone C18 column (4.6 × 250 mm, 5 μm) using an isocratic mobile phase consisting of phosphate buffer (pH 3.2) and acetonitrile (30%) + methanol (70%) in a 78:22% v/v ratio, at a flow rate of 1.0 mL/min. Detection was performed using a photodiode array detector at 258 nm. The method was validated in accordance with ICH Q2-(R2) guidelines. Validation parameters, including system suitability, linearity, accuracy, precision, robustness, sensitivity, and solution stability, were found within acceptable limits. The proposed method was successfully applied for the analysis of the stability study of MGF and to analyze the release kinetics of MGF SLNs, formulated via high-pressure homogenization and the sonication technique. The results confirm the applicability of the developed RP-HPLC method for routine quality control of combination nanocarrier systems.
New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases
Paka Sravan Kumar, Triveni Kodi, Adarsh Gopinathan, Bharath Harohalli Byregowda, Krishnadas Nandakumar, Anoop Kishore
Cell Biochemistry and Function, 2026
Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins. These stressors often cause overproduction of reactive oxygen species (ROS), leading to oxidative stress following inflammation. This cascade causes and accelerates various disorders, such as diabetes, neurodegenerative, respiratory, cardiovascular, autoimmune. This disease, in turn, becomes internal stressors, perpetuating cellular dysfunction through sustained ROS production and chronic inflammation, creating a self‐amplifying cycle that can lead to degenerative outcomes and organ failure. To cope with these stressors, cells initiate defense and protective mechanisms like antioxidant and heat shock proteins (HSPs). However, HSPs rapidly work to correct protein misfolding, mitigate oxidative damage, and reduce inflammation in response to external and internal stressors. HSPs increase the cell's efficiency to lower ROS levels and maintain the redox balance. On the other hand, cellular antioxidant regulatory role of HSPs includes suppressing apoptosis, modulating inflammatory signaling pathways (such as NF‐κB, MAPK, JAK‐SAT), inflammatory mediators (including TNF‐α, IL‐1β, IL‐6) and maintaining proteostasis, Therefore, HSPs play a significant role in cellular survival and function under stress. However, targeting HSPs represents a promising future strategy for managing stress related conditions with a variety of diseases.
Morin protects against palmitic acid-induced diabetic cardiomyopathy via SIRT6 activation and mitochondrial preservation
K. P 10.7324/JAPS.2026.261812, P. V Anuranjana, Krupa Thankam George, Krishnaprasad Baby, Fathima Beegum, Navjot Kanwar, Nitesh Kumar, Krishnadas Nandakumar, Abhinav Kanwal
Journal of Applied Pharmaceutical Science, 2026
Diabetic cardiomyopathy (DCM) is a serious diabetes complication marked by cardiac dysfunction and structural abnormalities. Mitochondrial dysfunction, driven by lipotoxicity and glucotoxicity, is central to DCM pathogenesis. SIRT6, a sirtuin family protein, is a potential therapeutic target due to its role in mitochondrial protection. This study explored morin, a natural flavonoid, as a SIRT6 activator to protect against palmitic acid-induced cardiomyopathy in H9c2 cells. In silico molecular docking identified morin as a potential SIRT6 activator with strong binding affinity, especially at residues ASP116 and PHE82. In vitro studies in H9c2 cardiomyoblasts confirmed morin’s protective effects against palmitic acid-induced toxicity. Morin pretreatment improved cell viability and reduced cytotoxicity. It enhanced glucose uptake, preserved mitochondrial membrane potential, and protected against mitochondrial damage. Morin also decreased reactive oxygen species (ROS), and lowered early and late apoptosis rates, showing strong anti-apoptotic effects. Additionally, morin upregulated SIRT6 and OPA1 expression, key genes for mitochondrial function and protection. These results suggest morin’s cardioprotective effects involve SIRT6 activation, mitochondrial protection, antioxidant activity, and anti-apoptotic mechanisms. By upregulating SIRT6 and OPA1, morin may counteract mitochondrial dysfunction in DCM. This study highlights morin’s therapeutic potential as a natural compound for DCM treatment, warranting further preclinical and clinical research.
Nanoemulsion as a promising drug delivery strategy for effective eradication of Helicobacter pylori: current insights
Moumita Saha, Ashutosh Gupta, Shivani Kunkalienkar, Namdev Dhas, Shiran Shetty, Abhishek Gupta, Srinivas Mutalik, Nandakumar Krishnadas, Raghu Chandrashekar, Nagalakshmi Narasimhaswamy, Sudheer Moorkoth
Drug Delivery and Translational Research, 2026
Enhanced Anticancer Activity in HR +/HER2 + Breast Cancer Cells Using Trastuzumab-Conjugated Liposomes co-loaded with siRNA and Tamoxifen
Gautam Kumar, Farmiza Begum, Prasada Chowdari Gurram, Bharath H. B., Prashansha Mullick, Krishnadas Nandakumar, Srinivas Mutalik, Chamalamudi Mallikarjuna Rao
Bionanoscience, 2025
Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics
Soji Soman, Sanjay Kulkarni, Jeena John, Milan Paul, Krishnadas Nandakumar, Swati Biswas, Sajan D. George, Srinivas Mutalik
International Journal of Pharmaceutics X, 2025
Design and Characterization of Novel Gastroretentive Drug Delivery System of Antibiotics and Piperine for the Eradication of H. pylori Infection
Ashutosh Gupta, Moumita Saha, Shivani Shailesh Kunkalienkar, Aadarsh Ghurye, Shweta Verma, Jahnavy Joshi, Abhishek Jha, Srinivas Mutalik, Shiran Shetty, Raghu Chandrashekar Hariharapura, Ashwini Aithal, K Nandakumar, Raviraja N. Seetharam, Sudheer Moorkoth
Molecular Pharmaceutics, 2025
Resveratrol, a calorie restriction mimetic, protects AlCl3-induced neurotoxicity and cognitive deficits in rats via inhibition of oxidative stress
Vijay S. Benade, Pradeep Jayarajan, Nandakumar Krishnadas, Ramakrishna Nirogi
Naunyn Schmiedeberg S Archives of Pharmacology, 2025
Corrigendum to “Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors” [Biochem. Biophys. Res. Commun. 729 (2024) 150348] (Biochemical and Biophysical Research Communications (2024) 729, (S0006291X24008842), (10.1016/j.bbrc.2024.150348))
Charudatt Samant, Ramesh Kale, K. Sreedhara Ranganath Pai, Krishnadas Nandakumar, Mandar Bhonde
Biochemical and Biophysical Research Communications, 2025
Exploring the Hepatoprotective Effects of Naringin: A Systematic Review and Meta-Analysis of Preclinical Evidence
Muhammed Fayaz, Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar
Planta Medica, 2025
Targeting Urease: A Promising Adjuvant Strategy for Effective Helicobacter pylori Eradication
Shivani Kunkalienkar, Neha S. Gandhi, Ashutosh Gupta, Moumita Saha, Aravinda Pai, Shiran Shetty, Abhishek Gupta, Namdev Dhas, Raghu Chandrashekar Hariharapura, K. Nandakumar, Nagalakshmi Narasimhaswamy, Sudheer Moorkoth
ACS Omega, 2025
Exploring Astragaloside IV in Ischemic Heart Disease: A Comprehensive Systematic Review and Meta-Analysis of Preclinical Cardiotoxicity Models
Alosh Greeny, Gollapalle Lakshminarayanashastry Viswanatha, Rekha Raghuveer Shenoy, Shylaja Hanumanthappa, Dinesh Kumar Chellappan, Jagnoor Singh Sandhu, Saumya Khanna, Nandakumar Krishnadas
Journal of Biochemical and Molecular Toxicology, 2025
Drugging the Undruggable and beyond: Emerging precision oncology approaches to target acquired resistance to KRAS G12C and KRAS G12D inhibitors
Ramesh Kale, Charudatt Samant, Krishnadas Nandakumar, K. Sreedhara Ranganath Pai, Mandar Bhonde
Biochemical and Biophysical Research Communications, 2025
Flavonoids regulating NLRP3 inflammasome: a promising approach in alleviating diabetic peripheral neuropathy
Saumya Khanna, Sachindra Kumar, Pratyasha Sharma, Rajni Daksh, Krishnadas Nandakumar, Rekha Raghuveer Shenoy
Inflammopharmacology, 2025
Biochanin-A as SIRT-1 modulator in preventing statin-associated diabetogenesis: An in vitro study
Anuranjana Veedu, Divya Kunhipurayil, Fathima Beegum, Krupa George, Abhinav Kanwal, Rekha Shenoy, Krishnadas Nandakumar
Biomedical Reports, 2025
Correction to: Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs (European Journal of Drug Metabolism and Pharmacokinetics, (2025), 50, 2, (119-135), 10.1007/s13318-024-00931-2)
Veera Raghava Chowdary Palacharla, Ramakrishna Nirogi, Nitesh Kumar, Krishnadas Nandakumar
European Journal of Drug Metabolism and Pharmacokinetics, 2025
Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs
Veera Raghava Chowdary Palacharla, Ramakrishna Nirogi, Nitesh Kumar, Krishnadas Nandakumar
European Journal of Drug Metabolism and Pharmacokinetics, 2025
Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment
Jeena John, Subham Das, Anu Kunnath, Jayesh Mudgal, Krishnadas Nandakumar
Metabolic Brain Disease, 2025
Alpha lipoic acid: advancing insights in diabetic neuropathy through updated systematic review and meta-analysis
Susmita Das, Gollapalle Lakshminarayanashastry Viswanatha, Krishnadas Nandakumar, Anoop Kishore, Shylaja Hanumanthappa
Exploration of Neuroprotective Therapy, 2025
Systematic review and meta-analysis of Tanacetum parthenium: evaluating its efficacy in migraine relief
Vineet Nelaturi, Gollapalle Lakshminarayanashastry Viswanatha, Rekha R. Shenoy, Saumya Khanna, Nandakumar Krishnadas
Natural Product Research, 2025
APPLICATIONS OF CONTOURS AND PIXEL VALUE SUMMATION IN DETERMINING THREE-DIMENSIONAL SIGNAL INTENSITIES
A. Kishore, P.S. Kumar, K. Triveni, A. Gopinathan, K. Nandakumar, D.S. Purushothama
International Journal of Applied Mathematics, 2025
Computational design, synthesis, in vitro and in vivo evaluation of a 3,4-methylenedioxyphenol (sesamol) derivative as an NRF2/HO-1 pathway activator for protection against drug-induced liver injury
Ajay Mili, Sumit Birangal, Krishnadas Nandakumar, Raghu Chandrashekar Hariharapura, Nitesh Kumar, Aravinda Pai, Richard Lobo
Rsc Advances, 2025
Design and development of ultra-flexible combisomal gel for non-invasive delivery of 4-hydroxytamoxifen and hesperidin in breast cancer treatment
Cynthia Lizzie Lobo, Ananya S, Manohar Mahadev, Amitha Shetty, Srinivas Hebbar, Nandakumar Krishnadas, Imojara Anna, Akhilesh Dubey, Sally A. El-Zahaby
Journal of Dispersion Science and Technology, 2025
The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation
Amrita Arup Roy, Abhijeet Pandey, Namdev Dhas, Manasa Manjunath Hegde, Harendra S. Parekh, Sai Balaji Andugulapati, Krishnadas Nandakumar, Bola Sadashiva Satish Rao, Srinivas Mutalik
Advances in Pharmacological and Pharmaceutical Sciences, 2025
Nose-to-brain Drug Delivery System: An Emerging Approach to Chemotherapy-induced Cognitive Impairment
Shireesha Jannapu Reddy, Srinivas Mutalik, Gollapalle Lakshminarayanashastry Viswanatha, Gautam Kumar, Jeena John, Mallikarjuna Rao Chamallamudi, Arpita Das, Sudip Das, Krishnadas Nandakumar
Pharmaceutical Nanotechnology, 2025
Identification of phytomolecules as isoform and mutation specific PI3K-α inhibitor for protection against breast cancer using e-pharmacophore modeling and molecular dynamics simulations
Ajay Mili, Sumit Birangal, Jyothi Giridhar, Krishnadas Nandakumar, Richard Lobo
BMC Chemistry, 2024
New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
Triveni kodi, Runali Sankhe, Adarsh Gopinathan, Krishnadas Nandakumar, Anoop Kishore
Journal of Neuroimmune Pharmacology, 2024
Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease
Akshatha P. Kamath, Pawan Ganesh Nayak, Jeena John, Srinivas Mutalik, Ashok Kumar Balaraman, Nandakumar Krishnadas
Neuropharmacology, 2024
Transferrin-conjugated UiO-66 metal organic frameworks loaded with doxorubicin and indocyanine green: A multimodal nanoplatform for chemo-photothermal-photodynamic approach in cancer management
Soji Soman, Sanjay Kulkarni, Jeena John, P. Vineeth, Sheikh F Ahmad, Sajan D George, Krishnadas Nandakumar, Srinivas Mutalik
International Journal of Pharmaceutics, 2024
Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors
Charudatt Samant, Ramesh Kale, K. Sreedhara Ranganath Pai, Krishnadas Nandakumar, Mandar Bhonde
Biochemical and Biophysical Research Communications, 2024
Role of Hydroalcoholic Extracts of Aegle marmelos (AM) Leaves and Tamarindus indica (TI) Seeds on High Fat High Sugar Diet Induced Hyperlipidemia in Rodent Models
Jay Prakash, Smita Shenoy, Krishnadas Nandakumar, Archana Parampalli Raghavendra, Anoop Kishore
Biomedical and Pharmacology Journal, 2024
DoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori
Moumita Saha, Ashutosh Gupta, Shiran Shetty, Srinivas Mutalik, K. Nandakumar, H. Raghu Chandrashekar, Namdev Dhas, S. Moorkoth
Chromatographia, 2024
Docosahexaenoic Acid and Pregnancy: A Systematic Review and Meta-Analysis of the Association with Improved Maternal and Fetal Health
Kiran Bilgundi, Gollapalle Lakshminarayanashastry Viswanatha, Kowshik Muttur Purushottam, Jeena John, Akshatha P. Kamath, Anoop Kishore, Pawan Ganesh Nayak, Krishnadas Nandakumar
Nutrition Research, 2024
Jojoba Oil Hastens Dexamethasone Induced Delayed Wound Healing: A Preclinical Study
Farmiza Begum, Pooja J Kotian, Snigdha Hiremath, Atharva Ramdasi, Apoorva Sharma, Fathima Beegum, Prasada Chowdhari Gurram, Madhavan Nampoothiri, Nandakumar Krishnadas, Rekha R Shenoy
Pharmaceutical Sciences, 2024
INVESTIGATING THE ROLE OF SESAMOL IN PROMOTING THE HEALING OF DIABETIC WOUNDS BY ANALYZING MOLECULAR EXPRESSION PATTERNS IN HUMAN DIABETIC DERMAL FIBROBLASTS
Fathima Beegum, Anuranjana P V, Krupa thankam George, Divya K P, Farmiza Begum, Nandakumar Krishnadas, Rekha R Shenoy
Journal of Applied Pharmaceutical Research, 2024
A computational study to identify Sesamol derivatives as NRF2 activator for protection against drug-induced liver injury (DILI)
Ajay Mili, Sumit Birangal, Krishnadas Nandakumar, Richard Lobo
Molecular Diversity, 2024
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis
Anvita Rabade, Gollapalle Lakshminarayanashastry Viswanatha, Krishnadas Nandakumar, Anoop Kishore
Inflammopharmacology, 2024
SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs
K. P. Divya, Navjot Kanwar, P. V. Anuranjana, Gautam Kumar, Fathima Beegum, Krupa Thankam George, Nitesh Kumar, K. Nandakumar, Abhinav Kanwal
Cardiovascular Toxicology, 2024
Trastuzumab-conjugated liposomes for co-delivery of paclitaxel and anti-abcb1 siRNA in HER2-positive breast cancer: In vitro and in vivo evaluations
Gautam Kumar, Prashansha Mullick, Sai Balaji Andugulapati, Abhisheik Chowdary Eedara, Nitesh Kumar, Srinivas Mutalik, Krishnadas Nandakumar, Mallikarjuna Rao Chamallamudi
Journal of Drug Delivery Science and Technology, 2024
Investigation of the cellular and molecular effects of dehydrozingerone formulation on various days of diabetic wound repair
Farmiza Begum, Krishnadas Nandakumar, Rekha Raghuveer Shenoy
3 Biotech, 2024
Mangiferin Analysis: Comprehensive RP-HPLC Method Development and Validation in Both Bulk and Pharmaceutical Dosage Forms
Jannapu Reddy Shireesha, Gautam Kumar, Srinivas Mutalik, Krishnadas Nandakumar
Research Journal of Pharmacy and Technology, 2024
Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol
Ajay Mili, Priyobrat Rajkhowa, Krishnadas Nandakumar, Richard Lobo
F1000research, 2024
Neuroprotective Effects of Metformin and Berberine in Lipopolysaccharide-Induced Sickness-Like Behaviour in Mice
Triveni Kodi, Sharanya Praveen, Sravan Kumar Paka, Runali Sankhe, Adarsh Gopinathan, Nandakumar Krishnadas, Anoop Kishore
Advances in Pharmacological and Pharmaceutical Sciences, 2024
Inhibition of SGK1 potentiates the anticancer activity of PI3K inhibitor in NSCLC cells through modulation of mTORC1, p-ERK and β-catenin signaling
Ramesh Kale, Charudatt Samant, Anand Bokare, Mahip Verma, Krishnadas Nandakumar, Mandar Bhonde
Biomedical Reports, 2023
Enhancing temozolomide antiglioma response by inhibiting O6-methylguanine-DNA methyltransferase with selected phytochemicals: in silico and in vitro approach
R. J. A. Vibhavari, Vanishree Rao, Sri Pragnya Cheruku, B. Harish Kumar, Swastika Maity, Krishnadas Nandakumar, Lalit Kumar, Chetan Hasmukh Mehta, Usha Nayak, Mallikarjuna Rao Chamallamudi, Nitesh Kumar
3 Biotech, 2023
Sesamol combats diabetogenic effects of atorvastatin through GLUT-4 expression and improved pancreatic viability
Raghuvir Keni, Pawan Ganesh Nayak, Nitesh Kumar, Anoop Kishore, Sulaiman Mohammed Alnasser, Farmiza Begum, Karthik Gourishetti, Krishnadas Nandakumar
3 Biotech, 2023
Box–Behnken Design-Aided Validation and Optimization of a Stability-Indicating Reverse Phase-HPLC Method for the Estimation of Tamoxifen Citrate in Lipidic Nano-Vesicles
Gautam Kumar, Prashansha Mullick, Krishnadas Nandakumar, Srinivas Mutalik, Mallikarjuna Rao Chamallamudi
Journal of Chromatographic Science, 2023
Effect of Coadministration of Hydroalcoholic Extracts of Aegle marmelos Leaves and Tamarindus indica Seeds on Streptozocin-Nicotinamide Induced Type-2 Diabetic Rat Model
Jay Prakash, Smita Shenoy, Archana P Raghavendra, Krishnadas Nandakumar, Anoop Kishore
International Journal of Pharmaceutical Quality Assurance, 2023
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Mahika Joshi, Priyanka Hiremath, Jeena John, Niraja Ranadive, Krishnadas Nandakumar, Jayesh Mudgal
Pharmacological Reports, 2023
Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation
Ashutosh Gupta, Shiran Shetty, Srinivas Mutalik, Raghu Chandrashekar H, Nandakumar K, Elizabeth Mary Mathew, Abhishek Jha, Brahmeshwar Mishra, Siddheesh Rajpurohit, Gundawar Ravi, Moumita Saha, Sudheer Moorkoth
Heliyon, 2023
Dehydrozingerone promotes healing of diabetic foot ulcers: a molecular insight
Farmiza Begum, Suman Manandhar, Gautam Kumar, Raghuvir Keni, Runali Sankhe, Prasada Chowdari Gurram, Fathima Beegum, Meka Sai Teja, Krishnadas Nandakumar, Rekha R. Shenoy
Journal of Cell Communication and Signaling, 2023
Diabetic wound healing approaches: an update
Raghuvir Keni, Farmiza Begum, Karthik Gourishetti, Gollapalle Lakshminarayanashastry Viswanatha, Pawan Ganesh Nayak, Krishnadas Nandakumar, Rekha R Shenoy
Journal of Basic and Clinical Physiology and Pharmacology, 2023
Amelioration of Doxorubicin-Induced Cognitive Impairment by Quercetin in a Rat Model of Breast Cancer
Grandhi Venkata Ramalingayya, Jeena John, Karthik Gourishetti, Pawan Ganesh Nayak, C. Mallikarjuna Rao, Anoop Kishore, Sulaiman M. Alnasser, Shalam M. Hussain, Nandakumar Krishnadas
Revista Brasileira De Farmacognosia, 2023
Molecular docking and dynamics guided approach to identify potential anti-inflammatory molecules as NRF2 activator to protect against drug-induced liver injury (DILI): a computational study
Ajay Mili, Subham Das, Krishnadas Nandakumar, Richard Lobo
Journal of Biomolecular Structure and Dynamics, 2023
Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond O-6-Methylguanine-DNA Methyltransferase
Nitesh Kumar, Vanishree Rao, Gautam Kumar, R.J.A. Vibhavari, Krishnadas Nandakumar, Nanasaheb D. Thorat, Mallikarjuna Rao Chamallamudi
CNS and Neurological Disorders Drug Targets, 2023
Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
P.V. Anuranjana, Fathima Beegum, Divya K.P, Krupa Thankam George, G.L. Viswanatha, Pawan G. Nayak, Abhinav Kanwal, Anoop Kishore, Rekha R. Shenoy, K. Nandakumar
F1000research, 2023
Brain-Targeted Nano-Architectures for Efficient Drug Delivery and Sensitization in Glioblastoma
Jeswanthi Aishwarya Vibhavari Ravuluri, Vanishree Rao, Gautam Kumar, Suman Manandhar, Sri Pragnya Cheruku, Priya Bisht, Mallikarjuna Rao Chamallmudi, Krishnadas Nandakumar, Lalit Kumar, Nitesh Kumar
Current Pharmaceutical Design, 2023
Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
Jeena John, Manas Kinra, Niraja Ranadive, Raghuvir Keni, Pawan Ganesh Nayak, Rajesh N. Jagdale, Syed M. Ahmed, Kaggundi V. Raghavendra, Jayesh Mudgal, K. Nandakumar
Scientific Reports, 2022
Development and Pharmacological assessment of dehydrozingerone gel formulation on imiquimod-induced psoriasis in mice
Gangadhar Hari, Anusha Prabhu, Chaitanyamayee Kalakota, Jeslin Johnson, Kufaila Mansoor, Rekha R Shenoy, Karkala Sreedhara Ranganath Pai, Krishnadas Nandakumar
Research Journal of Pharmacy and Technology, 2022
Box–Behnken Design-Based Development and Validation of a Reverse-Phase HPLC Analytical Method for the Estimation of Paclitaxel in Cationic Liposomes
Gautam Kumar, Prashansha Mullick, Krishnadas Nandakumar, Srinivas Mutalik, Chamallamudi Mallikarjuna Rao
Chromatographia, 2022
Notch signaling: A possible therapeutic target and its role in diabetic foot ulcers
Farmiza Begum, Raghuvir Keni, Tejas N. Ahuja, Fathima Beegum, Krishnadas Nandakumar, Rekha R. Shenoy
Diabetes and Metabolic Syndrome Clinical Research and Reviews, 2022
A systematic review and meta-analysis on the cardio-protective activity of naringin based on pre-clinical evidences
Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Raghuvir Keni, Krishnadas Nandakumar, Subbanna Rajesh
Phytotherapy Research, 2022
Cognition enhancing effect of rosemary (Rosmarinus officinalis L.) in lab animal studies: a systematic review and meta-analysis
S.M. Hussain, A.F. Syeda, M. Alshammari, S. Alnasser, N.D. Alenzi, S.T. Alanazi, K. Nandakumar
Brazilian Journal of Medical and Biological Research, 2022
Sirtuins as therapeutic targets for improving delayed wound healing in diabetes
Fathima Beegum, Anuranjana P. V., Krupa Thankam George, Divya K. P., Farmiza Begum, Nandakumar Krishnadas, Rekha R. Shenoy
Journal of Drug Targeting, 2022
Evolving Era of “Sponges”: Nanosponges as a Versatile Nanocarrier for the Effective Skin Delivery of Drugs
Srinivas Mutalik, Prashansha Mullick, Aswathi R. Hegde, Divya Gopalan, Abhijeet Pandey, Krishnadas Nandakumar, Sanyog Jain, Gowthamarajan Kuppusamy
Current Pharmaceutical Design, 2022
A comprehensive review on Sesamum indicum L.: Botanical, ethnopharmacological, phytochemical, and pharmacological aspects
Ajay Mili, Subham Das, Krishnadas Nandakumar, Richard Lobo
Journal of Ethnopharmacology, 2021
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction
Urja Kanojia, Shrikant Gyaneshwar Chaturbhuj, Runali Sankhe, Maushami Das, Raviteja Surubhotla, Nandakumar Krishnadas, Karthik Gourishetti, Pawan Ganesh Nayak, Anoop Kishore
CNS and Neurological Disorders Drug Targets, 2021
Animal models of chemotherapy-induced cognitive decline in preclinical drug development
Jeena John, Manas Kinra, Jayesh Mudgal, G. L. Viswanatha, K. Nandakumar
Psychopharmacology, 2021
Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1α, NF-κB, and VEGF pathways
Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar, Subbanna Rajesh, CH K. V. L. S. N. Anjana Male
Inflammopharmacology, 2021
In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy
Abhishek Shah, Aarti Abhishek Shah, Krishnadas Nandakumar, Avinash Kumar, Aravinda Pai, Richard Lobo
3 Biotech, 2021
Restoring chemo-sensitivity to temozolomide via targeted inhibition of poly (ADP-ribose) polymerase-1 by naringin in glioblastoma
Vanishree Rao, Sri Pragnya Cheruku, Suman Manandhar, R. J. A. Vibhavari, Krishnadas Nandakumar, C. Mallikarjuna Rao, V. Ravichandiran, Nitesh Kumar
Chemical Papers, 2021
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat
Raghuvir Keni, Abinitha Sekhar, Karthik Gourishetti, Pawan G. Nayak, Manas Kinra, Nitesh Kumar, Rekha R. Shenoy, Anoop Kishore, Krishnadas Nandakumar
Current Drug Targets, 2021
The prophylactic approach of sesamol and 3′,4′-(Methylenedioxy)acetophenone to prevent associated cardiotoxicity of doxorubicin at high dose in prostate cancer rat model
A. Shah, A. A. Shah, K. Nandakumar, D. S. Rekunge, G. U. Chaturbhuj, A. Kishore, P. G. Nayak, R. Lobo
Rasayan Journal of Chemistry, 2021
Mechanistic targets for BPH and prostate cancer–a review
Abhishek Shah, Aarti Abhishek Shah, Nandakumar K, Richard Lobo
Reviews on Environmental Health, 2021
Naringin exhibited anti-parkinsonian like effect against haloperidol-induced catalepsy in mice
Nitesh Kumar, Remya James, Shristi Sinha, Manas Kinra, P.V. Anuranjana, Krishnadas Nandakumar
Research Journal of Pharmacy and Technology, 2021
Erratum: Neuroprotective effect of mulmina™ against chemotherapy-induced cognitive decline in normal mice (Biomed Rep, (2021) 14, 1, 10.3892/br.2020.1377)
Manas Kinra, Niraja Ranadive, Karthik Gourishetti, Pawan Nayak, Rajesh Jagdale, Syed Ahmed, Kaggundi Raghavendra, Jayesh Mudgal, Krishnadas Nandakumar
Biomedical Reports, 2021
Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study
Amita Rai, Meghna Gill, Manas Kinra, Liston Augustine Dsouza, Suhani Sumalatha, Swapnil Raj, Raghavendra Shetty, Krishnadas Nandakumar, Mallikarjuna Rao Chamallamudi, Nitesh Kumar
Andrologia, 2020
Botrops derived hemocoagulase formulation a probable agent for diabetic wound healing
Raghuvir Keni, Karthik Gourishetti, Manas Kinra, Pawan G. Nayak, Rekha Shenoy, Krishnadas Nandakumar, Rajesh N. Jagdale, K. V. Raghavendra, Syed Mushtaq Ahmed
3 Biotech, 2020
Evaluation of hepatoprotective effect of a polyherbal megakutki against paracetamol-induced hepatotoxicity
Asha Elizabeth Giri, Vanishree Rao, Sandeep Singhal, Karthik Gourishetti, Subhankar Biswas, Krishnadas Nandakumar, Mallikarjuna Rao Chamllamudi, Jeetesh Dave, Rakesh Dave, Suhani Sumalatha, Nitesh Kumar
Indian Journal of Pharmaceutical Education and Research, 2020
Correction to: Efficacy and safety of inhalation budesonide in the treatment of pediatric asthma in the emergency department: a systematic review and meta-analysis (Pharmacological Reports, (2020), 72, 4, (783-798), 10.1007/s43440-020-00098-y)
Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar, Marikunte Venkatanarasappa Venkataranganna, Nunna Bheema Lingeswara Prasad
Pharmacological Reports, 2020
Efficacy and safety of inhalation budesonide in the treatment of pediatric asthma in the emergency department: a systematic review and meta-analysis
Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar, Marikunte Venkatanarasappa Venkataranganna, Nunna Bheema Lingeswara Prasad
Pharmacological Reports, 2020
Biologicals to direct nanotherapeutics towards HER2-positive breast cancers
Gautam Kumar, Krishnadas Nandakumar, Srinivas Mutalik, Chamallamudi Mallikarjuna Rao
Nanomedicine Nanotechnology Biology and Medicine, 2020
COVID-19: Emergence, Spread, Possible Treatments, and Global Burden
Raghuvir Keni, Anila Alexander, Pawan Ganesh Nayak, Jayesh Mudgal, Krishnadas Nandakumar
Frontiers in Public Health, 2020
Sesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials
Girish A. Ghadge, Karthik Gourishetti, Mallikarjuna Rao Chamallamudi, Gopalan Kutty Nampurath, Krishnadas Nandakumar, Nitesh Kumar
3 Biotech, 2020
Corrigendum: Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress (Biomed Rep, (2019) 11, (79-84), 10.3892/br.2019.1226)
Amita Rai, Meghna Gill, Manas Kinra, Raghavendra Shetty, Nandakumar Krishnadas, C. Rao, Suhani Sumalatha, Nitesh Kumar
Biomedical Reports, 2020
An appraisal of current pharmacological perspectives of sesamol: A review
Bellamkonda Bosebabu, Sri Pragnya Cheruku, Mallikarjuna Rao Chamallamudi, Madhavan Nampoothiri, Rekha R. Shenoy, Krishnadas Nandakumar, Vipan K. Parihar, Nitesh Kumar
Mini Reviews in Medicinal Chemistry, 2020
Sesamol-loaded plga nanosuspension for accelerating wound healing in diabetic foot ulcer in rats
Karthik Gourishetti, Raghuvir Keni, Pawan Ganesh Nayak, Srinivas Reddy Jitta, Navya Ajitkumar Bhaskaran, Lalit Kumar, Nitesh Kumar, Krishnadas Nandakumar, Rekha Shenoy
International Journal of Nanomedicine, 2020
Neuroprotective effect of mulmina™ against chemotherapy-induced cognitive decline in normal rats
Manas Kinra, Niraja Ranadive, Karthik Gourishetti, Pawan Nayak, Rajesh Jagdale, Syed Ahmed, Kaggundi Raghavendra, Jayesh Mudgal, Krishnadas Nandakumar
Biomedical Reports, 2020
Sesamol and health - A comprehensive review
Abhishek Shah, Richard Lobo, Nandakumar Krishnadas, Raviteja Surubhotla
Indian Journal of Pharmaceutical Education and Research, 2019
Medhya rasayana restores memory function against doxorubicin-induced cognitive decline: Possibly by its neuroprotective effect
Karthik Gourishetti, Sawan Ghetia, Ligin Jacob, Sanchari Basu Mallik, Pawan Ganesh Nayak, Anoop Kishore, Krishnadas Nandakumar, Sulaiman Mohammed Alnaseer, Shalam Mohamed Hussain
Indian Journal of Pharmaceutical Education and Research, 2019
Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma
Grandhi Venkata Ramalingayya, Karthik Gourishetti, Pawan G. Nayak, Chamallamudi Mallikarjuna Rao, Anoop Kishore, Sulaiman M. Alnaseer, Shalam M. Hussain, Krishnadas Nandakumar
Journal of Environmental Pathology Toxicology and Oncology, 2019
Catechin ameliorates depressive symptoms in sprague dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress
Amita Rai, Meghna Gill, Manas Kinra, Raghavendra Shetty, Nandakumar Krishnadas, C. Rao, Suhani Sumalatha, Nitesh Kumar
Biomedical Reports, 2019
Pharmacophore and atom based 3D QSAR studies on the novel 5-alpha-reductase inhibitors
Abhishek Shah, Richard Lobo, Nandakumar Krishnadas, Aravinda Pai
Indian Journal of Pharmaceutical Education and Research, 2018
Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders
Mahip K. Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V. S. Nemmani
Expert Opinion on Therapeutic Targets, 2018
Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala2GIP in rat model of Huntington's disease
Mahip K. Verma, Rajan Goel, Krishnadas Nandakumar, Kumar V.S. Nemmani
European Journal of Pharmacology, 2018
Catechin, an active constituent of green tea, preserves skeletal muscle activity in dexamethasone induced cachexia by increasing acetylcholine sensitivity in muscles of wistar rats
Indian Journal of Experimental Biology, 2018
Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo
Krishnadas Nandakumar, GrandhiVenkata Ramalingayya, PawanG Nayak, RekhaR Shenoy, SanchariBasu Mallik, Karthik Gourishetti, ShalamM Hussain, ChamallamudiMallikarjuna Rao
Pharmacognosy Magazine, 2018
Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats
Sri Pragnya Cheruku, Grandhi Venkata Ramalingayya, Mallikarjuna Rao Chamallamudi, Subhankar Biswas, Krishnadas Nandakumar, Madhavan Nampoothiri, Karthik Gourishetti, Nitesh Kumar
Cytotechnology, 2018
Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations
Mukundkumar Rameshbhai Hirpara, Jyothsna Manikkath, K. Sivakumar, Renuka S. Managuli, Karthik Gourishetti, Nandakumar Krishnadas, Rekha R. Shenoy, Belle Jayaprakash, Chamallamudi Mallikarjuna Rao, Srinivas Mutalik
International Journal of Biological Macromolecules, 2018
Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp
Amita Rai, Snehashis Das, Mallikarjuna Rao Chamallamudi, Krishnadas Nandakumar, Raghavendra Shetty, Meghna Gill, Suhani Sumalatha, Raviraj Devkar, Karthik Gourishetti, Nitesh Kumar
Journal of Ethnopharmacology, 2018
Pinocembrin-enriched fractions of elytranthe parasitica (L.) danser modulates apoptotic and MAPK cellular signaling in HepG2 cells
Nimmy Kumar, Akhila H. Shrungeswara, Sanchari B. Mallik, Subhankar Biswas, Jesil Mathew, Krishnadas Nandakumar, Jessy Mathew, Richard Lobo
Anti Cancer Agents in Medicinal Chemistry, 2018
Combined administration of monosodium glutamate and high sucrose diet accelerates the induction of type 2 diabetes, vascular dysfunction, and memory impairment in rats
Kaja Saikrishna, Ringu Kumari, Kantamaneni Chaitanya, Subhankar Biswas, Pawan G. Nayak, Jayesh Mudgal, Anoop Kishore, Krishnadas Nandakumar
Journal of Environmental Pathology Toxicology and Oncology, 2018
Sodium valproate enhances doxorubicin-induced cognitive dysfunction in Wistar rats
Thaneshwar Verma, Sanchari Basu Mallik, G.V. Ramalingayya, Pawan G. Nayak, Anoop Kishore, K. Sreedhara R. Pai, Krishnadas Nandakumar
Biomedicine and Pharmacotherapy, 2017
Pinocembrin enriched fraction of Elytranthe parasitica (L.) Danser induces apoptosis in HCT 116 colorectal cancer cells
Nimmy Kumar, Subhankar Biswas, Akhila Hosur Shrungeswara, Sanchari Basu Mallik, Mathew Hipolith Viji, Jessy Elizabeth Mathew, Jesil Mathew, K. Nandakumar, Richard Lobo
Journal of Infection and Chemotherapy, 2017
Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats
Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Rao
Neuroreport, 2017
Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats
Grandhi V Ramalingayya, Sri Pragnya Cheruku, Pawan Nayak, Anoop Kishore, Rekha Shenoy, Chamallamudi Mallikarjuna Rao, Nandakumar Krishnadas
Drug Design Development and Therapy, 2017
Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice
Mahip K. Verma, Rajan Goel, Krishnadas Nandakumar, Kumar V.S. Nemmani
European Journal of Pharmacology, 2017
Insulin combined with glucose improves spatial learning and memory in aluminum chloride–induced dementia in rats
Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Rao
Journal of Environmental Pathology Toxicology and Oncology, 2017
Insulin protects against brain oxidative stress with an apparent effect on episodic memory in doxorubicin-induced cognitive dysfunction in wistar rats
Grandhi Venkata Ramalingayya, Vishwajeet Sonawane, Sri Pragnya Cheruku, Anoop Kishore, Pawan G. Nayak, Nitesh Kumar, Rekha S. Shenoy, Krishnadas Nandakumar
Journal of Environmental Pathology Toxicology and Oncology, 2017
Standardised extract of safed musli (Chlorophytum borivilianum) increases aphrodisiac potential besides being safe in male Wistar rats
S. Das, S. Singhal, N. Kumar, C. M. Rao, S. Sumalatha, J. Dave, R. Dave, K. Nandakumar
Andrologia, 2016
Pro-apoptotic and cytotoxic effects of enriched fraction of Elytranthe parasitica (L.) Danser against HepG2 Hepatocellular carcinoma
Nimmy Kumar, Subhankar Biswas, Asha Elizabeth Mathew, Subin Varghese, Jessy Elizabeth Mathew, K. Nandakumar, Jesil Mathew Aranjani, Richard Lobo
BMC Complementary and Alternative Medicine, 2016
In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, akt and p38 MAP kinase in L6 cells
Jayesh Mudgal, Priya Shetty, Neetinkumar D. Reddy, H. S. Akhila, Karthik Gourishetti, Geetha Mathew, Pawan G. Nayak, Nitesh Kumar, Anoop Kishore, Nampurath G. Kutty, Krishnadas Nandakumar, Rekha R. Shenoy, Chamallamudi M. Rao, Alex Joseph
Frontiers in Pharmacology, 2016
Female rats induced with mammary cancer as a relevant animal model for doxorubicin-induced chemobrain in vivo
Grandhi Venkata Ramalingayya, Pawan G Nayak, Rekha R Shenoy, Chamallamudi Mallikarjuna Rao, Krishnadas Nandakumar
Clinical and Experimental Pharmacology and Physiology, 2016
Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome
Sarine Sebastian Karot, Vasantharaju Gowdra Surenahalli, Anoop Kishore, Jayesh Mudgal, Krishnadas Nandakumar, Magith Thambi Chirayil, Geetha Mathew, Gopalan Kutty Nampurath
Journal of Diabetes, 2016
Evaluation of antidiarrhoeal effect of acetone extract fraction from the stem bark of T. Populnea
International Journal of Pharmacognosy and Phytochemical Research, 2016
Assessment of female rats for studying episodic memory and its deficit associated with doxorubicin-induced chemobrain
Grandhi Venkata Ramalingayya, Karthik Gourishetti, Anoop Kishore, Krishnadas Nandakumar
Clinical and Experimental Pharmacology and Physiology, 2016
Endothelium dependent and independent mechanisms of vasorelaxant activity of synthesized 2,5-disubstituted-1,3,4-oxadiazole derivatives in rat thoracic aorta-ex vivo and molecular docking studies
Zenab Attari, Jayesh Mudgal, Pawan G Nayak, Nandakumar Krishnadas, Revathi Rajappan, N. Gopalan Kutty
Letters in Drug Design and Discovery, 2016
Urinary tract infection treatment pattern of elderly patients in a tertiary hospital setup in south India: A prospective study
Ramanath Katta Venkatesh, Mukhyaprana M Prabhu, Krishnadas Nandakumar, K Sreedhara R Pai
Journal of Young Pharmacists, 2016
Antimicrobial, anticancer and cytotoxic activities of acetone extract fraction from stem bark of Thespesia populnea (Linn.)
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2016
Monitoring of adverse reactions in geriatric south Indian patients in a tertiary care teaching hospital: A prospective study
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2016
Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasks
Krishnadas Nandakumar, GrandhiVenkata Ramalingayya, Madhavan Nampoothiri, PawanG Nayak, Anoop Kishore, RekhaR Shenoy, ChamallamudiMallikarjuna Rao
Pharmacognosy Magazine, 2016
Sambar, an Indian dish prevents the development of dimethyl hydrazine-induced colon cancer: A preclinical study
Krishnadas Nandakumar, VutturuGanga Prasad, Neetinkumar Reddy, Albi Francis, PawanG Nayak, Anoop Kishore, MallikarjunaC Rao, Rekha Shenoy
Pharmacognosy Magazine, 2016
Atypical antidepressant activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione isolated from heart wood of Cedrus deodara, in rodents
Nitesh Kumar, Daniel Dhayabaran, Madhavan Nampoothiri, Krishnadas Nandakumar, A. Puratchikody, Natasha Lalani, Karima Dawood, Aanesha Ghosh
Korean Journal of Physiology and Pharmacology, 2014
Anticonvulsant activity of fraction isolated from ethanolic extract of heartwood of Cedrus deodara
Daniel Dhayabaran, Ebinezar Jeyaseeli Florance, Krishnadas Nandakumar, Alagarsamy Shanmugarathinam, Ayarivan Puratchikody
Journal of Natural Medicines, 2014
Protective effects of aqueous extract of Solanum nigrum Linn. leaves in rat models of oral mucositis
Alkesh Patel, Subhankar Biswas, Muhammed Haneefa Shoja, Grandhi Venkata Ramalingayya, K. Nandakumar
Scientific World Journal, 2014
Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer
V. Ganga Prasad, Shishir Kawade, B. S. Jayashree, Neetinkumar D. Reddy, Albi Francis, Pawan G. Nayak, Anoop Kishore, K. Nandakumar, C. Mallikarjuna Rao, Rekha R. Shenoy
Biomed Research International, 2014
Evaluation of in vitro antioxidant and in Vivo analgesic potential of Terminalia paniculata aqueous bark extract
Sahil Talwar, Pawan G. Nayak, Jayesh Mudgal, Piya Paul, Punit Bansal, Krishnadas Nandakumar
Journal of Medicinal Food, 2013
Impact of caffeic acid on aluminium chloride-induced dementia in rats
Kafeel A Khan, Nitesh Kumar, Pawan G Nayak, Madhavan Nampoothiri, Rekha R Shenoy, Nandakumar Krishnadas, C Mallikarjuna Rao, Jayesh Mudgal
Journal of Pharmacy and Pharmacology, 2013
A rat model against chemotherapy plus radiation-induced oral mucositis
Alkesh Patel, S. Rajesh, V.M. Chandrashekhar, Shivprakash Rathnam, Karishma Shah, C. Mallikarjuna Rao, K. Nandakumar
Saudi Pharmaceutical Journal, 2013
Hypoglycaemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats
Pakistan Journal of Pharmaceutical Sciences, 2013
Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents
Sahil Talwar, Hitesh V Jagani, Pawan G Nayak, Nitesh Kumar, Anoop Kishore, Punit Bansal, Rekha R Shenoy, Krishnadas Nandakumar
BMC Complementary and Alternative Medicine, 2013
Isolation and anxiolytic activity of 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione from the ethanolic extract of heart wood of Cedrus deodara
Daniel Dhayabaran, Jeyaseeli Florance, Krishnadas Nandakumar, Ayarivan Puratchikody
Medicinal Chemistry Research, 2012
Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum
Daniel Dhayabaran, Jeyaseeli Florance, Nandakumar Krsihnadas, Indumathi, Muralidhar
Revista Brasileira De Farmacognosia, 2012
Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones
Gollapalle L. Viswanatha, B. Janaki Priyadarshini, Nandakumar Krishnadas, Saravanan Janardhanan, Srinath Rangappa, Shylaja Hanumanthappa
Saudi Pharmaceutical Journal, 2012
Antidiarrhoeal activity of leaf extracts of Tylophora indica (Asclepiadaceae) in rodents
Pharmacologyonline, 2011
Analgesic, anti-inflammatory and antiarthritic activity of newly synthesized bicyclothieno 1, 2, 3 - triazines
Gollapalle Lakshminarayanashastry Viswanatha, Nagaraju Akinapally, N. Krishnadas, Srinath Rangappa, S. Janardhanan
Macedonian Journal of Medical Sciences, 2011
Antidiarrheal effect of fractions from stem bark of Thespesia populnea in rodents: Possible antimotility and antisecretory mechanisms
Gollapalle Lakshminaraya Shastry Viswanatha, Shylaja Hanumanthappa, Nandakumar Krishnadas, Srinath Rangappa
Asian Pacific Journal of Tropical Medicine, 2011
Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats
Sahil Talwar, K. Nandakumar, Pawan G. Nayak, Punit Bansal, Jayesh Mudgal, Vijay Mor, Chamallamudi Mallikarjuna Rao, Richard Lobo
Journal of Ethnopharmacology, 2011
Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum
Rajesh Kumar, G. Murugananthan, K. Nandakumar, Sahil Talwar
Phytomedicine, 2011
Highly active antiretroviral therapy induced adverse drug reactions in Indian human immunodeficiency virus positive patients
Radhakrishnan Rajesh, Sudha Vidyasagar, Krishnadas Nandakumar
Pharmacy Practice, 2011
Hypoglycaemic and anti-diabetic activity of stem bark extracts Erythrina indica in normal and alloxan-induced diabetic rats
A. Yashwant Kumar, K. Nandakumar, M. Handral, Sahil Talwar, Daniel Dhayabaran
Saudi Pharmaceutical Journal, 2011
Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna
Gollapalle Lakshminarayana shastry Viswanatha, Santosh Kumar Vaidya, Ramesh C, Nandakumar Krishnadas, Srinath Rangappa
Asian Pacific Journal of Tropical Medicine, 2010
Preparation of indegenous herbal formulation and its evalaution for antidiabetic activity
Pharmacologyonline, 2010
Anti-urolithiatic activity of heart wood extract of cedrus deodara in Rats
Ramesh C., Nandakumar Krishnadas, Rajesh Radhakrishnan, Srinath Rangappa, Gollapalle Lakshminarayana Shastry Viswanatha, Rajesh D, Murugananthan Gopal, Sahil Talwar
Journal of Complementary and Integrative Medicine, 2010
Anxiolytic and anticonvulsant activity of aqueous extract of stem bark of Erythrina variegata in rodents
International Journal of Pharmtech Research, 2010
Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice
Internet Journal of Pharmacology, 2009
Vasorelaxant effect in rat aortic rings through calcium channel blockage: A preliminary in vitro assessment of a 1,3,4-oxadiazole derivative
Girish R. Bankar, K. Nandakumar, Pawan G. Nayak, Anjali Thakur, Mallikarjuna Rao Chamallamudi, Gopalan Kutty Nampurath
Chemico Biological Interactions, 2009
Analgesic and antiinflammatory activity of leaf extracts of Commiphora caudata in rodents
Pharmacologyonline, 2009
Immunomodulatory activities of Wrightia tinctoria (Roxb.) R. Br bark extracts
Pharmacologyonline, 2009
Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.)
Pharmacologyonline, 2009
Antidiarrheal activity of stem bark extracts od Spathodea companulata in rodents
Pharmacologyonline, 2009
Antidiarrheal activity of methanolic extracts of seeds of Lepidium sativum
Journal of Natural Remedies, 2009
Hepatoprotective activity of ethanolic and aqueous extract of Terminalia belerica in rats
Pharmacologyonline, 2008
Preliminary phytochemical studies and antimicrobial activity of stem bark of Thespesia populnea
Pharmacologyonline, 2008
Synthesis, β-adrenergic receptor binding and antihypertensive potential of vanillin-derived phenoxypropanolamines
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2008
Comparative evaluation of analgesic, anti-inflammatory and antipyretic activity of leaves, stem and roots of Lantan camara
Pharmacologyonline, 2008
Antidiarrheal activity of alcoholic and aqueous extracts of stem bark of Thespesia populnea in rodents
Pharmacologyonline, 2007
Anxiolytic and anti convulsant activity of alcoholic extract of heartwood of Aquilaria agallocha roxb (thymelaeceae) in mice
Pharmacologyonline, 2007
Anxiolytic and anticonvulsant activity of alcoholic extract of heartwood of Aquilaria agallocha roxb, (Thymelaeceae) in mice
Pharmacologyonline, 2007
Hepatoprotective effect of root extracts of Tylophora Indica (wight & arn) against ethanol induced liver damage in rats
Toxicology International, 2007
Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals
Pharmacologyonline, 2007
A study on CNS effects of milk extract of nuts of Semecarpus anacardium. Linn, (Anacardiaceae)
Pharmacologyonline, 2007
β-Blocking activity of PP-34, a newly synthesized aryloxypropanolamine derivative, and its cardioprotective effect against ischaemia/reperfusion injury in laboratory animals
Lokesh K Bhatt, K Nandakumar, S L Bodhankar, Jyotika Bansal, Poonam Piplani
Journal of Pharmacy and Pharmacology, 2007
Study of drug-drug interaction between loperamide and α2 adrenergic receptor agonists in rodents
Indian Drugs, 2007
A study on adaptogenic activity of root extracts of Boerhaavia diffusa (Linn)
Indian Drugs, 2007
Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats
VenkatN Rao, Vipul Gujrati, Nilesh Patel, K Nandakumar, TS Gouda, Md. Shalam, SM Shanta Kumar
Indian Journal of Pharmacology, 2007
Anti-urolithiatic effect of petroleum ether extract stem bark of Crataeva adansonii in rats
Pankaj Gupta, Naimesh Patel, Lokesh Bhatt, G.N. Zambare, S.L. Bodhankar, B.B. Jain, K. Nandakumar
Pharmaceutical Biology, 2006
Isolated goat ileum preparation: An alternative to isolated ileum preparation from laboratory animals
K Nandakumar, PS Bhutada, Y Mundhada, KS Jain
Indian Journal of Pharmacology, 2006
Effect of two newly synthesized β blockers, DPJ 955 and DPJ 890 on ECG of anaesthetized mice
Indian Drugs, 2006
Cardioprotective effect of newly synthesized acyl amino substituted propanolamine derivatives, DPJ 955 and DPJ 890 against isoprenaline induced myocardial necrosis
Toxicology International, 2005
Selective β1-adrenoreceptor blocking activity of newly synthesized acyl amino-substituted aryloxypropanolamine derivatives, DPJ 955 and DPJ 890, in rats
K Nandakumar, S K Bansal, Randhir Singh, S L Bodhankar, D P Jindal, Mohane S Coumar, R Balaraman, S H Bhardwaj
Journal of Pharmacy and Pharmacology, 2005
Study of β-adrenoreceptor antagonistic activity of DPJ 904 in rats
K. Nandakumar, S.K. Bansal, Randhir Singh, A.J. Mohite, S.L. Bodhankar, D.P. Jindal, Mohane S. Coumar, R. Balaraman, S.H. Bhardwaj
Pharmacology, 2005
Experimental animal models to induce cardiac arrhythmias
SL Bodhankar, LK Bhatt, K Nandakumar
Indian Journal of Pharmacology, 2005
Antihypertensive effect of newly synthesized acyl amino substituted propanolamine derivatives, DPJ 890 and DPJ 955 in rats [1]
Indian Journal of Pharmacology, 2004
Synthesis, β-adrenergic blocking activity and β-receptor binding affinities of 1-substituted-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalates
Dharam Paul Jindal, Mohane S Coumar, K Nandakumar, Subhash Laxmanrao Bodhankar, Prasad Gopal Purohit, Kakasaheb Ramoo Mahadik, Giancarlo Bruni, Elga Collavoli, Paola Massarelli
Farmaco, 2003

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