Elena Salamanca-Fernandez

Scopus Publications

Sociodemographic determinants and temporal variability of blood lead levels (2003–2019) in a pooled analysis of nine studies in four European countries
Elena Salamanca-Fernández, Francisco M. Peinado, Marta Esteban-López, Vladimira Puklova, Rafael M. Poyatos, Eva Govarts, Michelle Laeremans, Martine Leermakers, Elly den Hond, Greet Schoeters, Aline Murawski, Susana Pedraza-Díaz, Tamás Szigeti, Veerle Verheyen, Nina Vogel, Till Weber, Domenica Hahn, Philipp Zimmermann, Marike Kolossa-Gehring, Mariana F. Fernandez, Juan Pedro Arrebola
Scientific Reports, 2025
Despite regulatory actions, lead (Pb) exposure remains a major environmental health concern worldwide due to its widespread occurrence and potential adverse effects. The aims of this study were to explore internal Pb exposure in EU citizens, identify its main sociodemographic determinants, and investigate temporal variations over the last decades. Blood Pb data from a total of 17,790 individuals from 9 biomonitoring studies conducted between 2003 and 2019 in four European countries [Belgium (FLEHS I-IV), teenagers and adults; Czech Republic (SZU), children and adults; Spain (BIOAMBIENT.ES), adults; Germany (ESB, GerES IV and V), with all three age groups] were used. The European Human Biomonitoring Initiative (HBM4EU) harmonized and integrated the different datasets. Linear mixed-model analyses were performed to explore exposure determinants related to Pb concentrations. All participants showed detectable blood Pb concentrations, with an overall mean concentration (± standard deviation) of 20.6 (± 16.7) µg/L. In multivariable analyses, older age at recruitment, smoking habit and residence in more urbanized areas were associated with higher Pb levels, whereas more recent sampling year and higher educational level with lower concentrations. After pooled analysis of individual data, no significant differences were found in the Pb levels of the European citizens studied, probably due to the heterogeneity of the studies included. Collaborative efforts between public health agencies, environmental regulators and communities must continue to monitor trends, explore emerging sources of exposure and refine strategies to ensure sustained progress in reducing Pb levels and protecting the health of European population.
Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies
Elena Salamanca-Fernández, Lydia Espín-Moreno, Alicia Olivas-Martínez, Ainhoa Pérez-Cantero, José L. Martín-Rodríguez, Rafael M. Poyatos, Fabio Barbone, Valentina Rosolen, Marika Mariuz, Luca Ronfani, Ľubica Palkovičová Murínová, Lucia Fábelová, Tamás Szigeti, Réka Kakucs, Amrit K. Sakhi, Line S. Haug, Birgitte Lindeman, Janja Snoj Tratnik, Tina Kosjek, Griet Jacobs, Stefan Voorspoels, Helena Jurdáková, Renáta Górová, Ida Petrovičová, Branislav Kolena, Marta Esteban, Susana Pedraza-Díaz, Marike Kolossa-Gehring, Sylvie Remy, Eva Govarts, Greet Schoeters, Mariana F. Fernández, Vicente Mustieles
Toxics, 2024
Based on toxicological evidence, children’s exposure to phthalates may contribute to altered neurodevelopment and abnormal regulation of brain-derived neurotrophic factor (BDNF). We analyzed data from five aligned studies of the Human Biomonitoring for Europe (HBM4EU) project. Ten phthalate metabolites and protein BDNF levels were measured in the urine samples of 1148 children aged 6–12 years from Italy (NACII-IT cohort), Slovakia (PCB-SK cohort), Hungary (InAirQ-HU cohort) and Norway (NEBII-NO). Serum BDNF was also available in 124 Slovenian children (CRP-SLO cohort). Children’s total, externalizing and internalizing behavioral problems were assessed using the Child Behavior Checklist at 7 years of age (only available in the NACII-IT cohort). Adjusted linear and negative binomial regression models were fitted, together with weighted quantile sum (WQS) regression models to assess phthalate mixture associations. Results showed that, in boys but not girls of the NACII-IT cohort, each natural-log-unit increase in mono-n-butyl phthalate (MnBP) and Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) was cross-sectionally associated with higher externalizing problems [incidence rate ratio (IRR): 1.20; 95% CI: 1.02, 1.42 and 1.26; 95% CI: 1.03, 1.55, respectively]. A suggestive mixture association with externalizing problems was also observed per each tertile mixture increase in the whole population (WQS—IRR = 1.15; 95% CI: 0.97, 1.36) and boys (IRR = 1.20; 95% CI: 0.96, 1.49). In NACII-IT, PCB-SK, InAirQ-HU and NEBII-NO cohorts together, urinary phthalate metabolites were strongly associated with higher urinary BDNF levels, with WQS regression confirming a mixture association in the whole population (percent change (PC) = 25.9%; 95% CI: 17.6, 34.7), in girls (PC = 18.6%; 95% CI: 7.92, 30.5) and mainly among boys (PC = 36.0%; 95% CI: 24.3, 48.9). Among CRP-SLO boys, each natural-log-unit increase in ∑DINCH concentration was associated with lower serum BDNF levels (PC: −8.8%; 95% CI: −16.7, −0.3). In the NACII-IT cohort, each natural-log-unit increase in urinary BDNF levels predicted worse internalizing scores among all children (IRR: 1.15; 95% CI: 1.00, 1.32). Results suggest that (1) children’s exposure to di-n-butyl phthalate (DnBP) and di(2-ethylhexyl) phthalate (DEHP) metabolites is associated with more externalizing problems in boys, (2) higher exposure to DINCH may associate with lower systemic BDNF levels in boys, (3) higher phthalate exposure is associated with higher urinary BDNF concentrations (although caution is needed since the possibility of a “urine concentration bias” that could also explain these associations in noncausal terms was identified) and (4) higher urinary BDNF concentrations may predict internalizing problems. Given this is the first study to examine the relationship between phthalate metabolite exposure and BDNF biomarkers, future studies are needed to validate the observed associations.
Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies
Andrea Rodríguez-Carrillo, Elena Salamanca-Fernández, Elly den Hond, Veerle J. Verheyen, Lucia Fábelová, Lubica Palkovicova Murinova, Susana Pedraza-Díaz, Argelia Castaño, José Vicente García-Lario, Sylvie Remy, Eva Govarts, Greet Schoeters, Nicolás Olea, Carmen Freire, Mariana F. Fernández
Environmental Research, 2023
BACKGROUND: Perfluoroalkyl substances (PFAS) and phthalates are synthetic chemicals widely used in various types of consumer products. There is epidemiological and experimental evidence that PFAS and phthalates may alter thyroid hormone levels; however, studies in children and adolescents are limited. AIM: To investigate the association of exposure to PFAS and phthalate with serum levels of thyroid hormones in European adolescents. METHODS: A cross-sectional study was conducted in 406 female and 327 male adolescents (14-17 years) from Belgium, Slovakia, and Spain participating in the Aligned Studies of the HBM4EU Project (FLEHS IV, PCB cohort, and BEA, respectively). Concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), free thyroxine (FT4), free triiodothyronine (FT3), and thyroid-stimulating hormone (TSH) were measured in sera from study participants, and urinary metabolites of six phthalates (DEP, DiBP, DnBP, BBzP, DEHP, and DiNP) and the non-phthalate plasticizer DINCH® were quantified in spot urine samples. Associations were assessed with linear regression and g-computational models for mixtures. Effect modification by sex was examined. RESULTS: In females, serum PFOA and the PFAS mixture concentrations were associated with lower FT4 and higher FT3 levels; MEP and the sums of DEHP, DiNP, and DINCH® metabolites (∑DEHP, ∑DiNP, and ∑DINCH) were associated with higher FT4; ∑DEHP with lower FT3; and the phthalate/DINCH® metabolite mixture with higher FT4 and lower FT3. In males, PFOA was associated with lower FT4 and the PFAS mixture with higher TSH levels and lower FT4/TSH ratio; MEP and ∑DiNP were associated with higher FT4; and MBzP, ∑DEHP, and the phthalate/DINCH® metabolite mixture with lower TSH and higher FT4/TSH. PFOA, mono-(2-ethyl-5-hydroxyhexyl) phthalate (OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (oxo-MEHP), and monocarboxyoctyl phthalate (MCOP) made the greatest contribution to the mixture effect. CONCLUSIONS: Results suggest that exposure to PFAS and phthalates is associated with sex-specific differences in thyroid hormone levels in adolescents.
Exposure to perfluoroalkyl substances (PFAS) and association with thyroid hormones in adolescent males
Carmen Freire, Fernando Vela-Soria, Francesca Castiello, Elena Salamanca-Fernández, Raquel Quesada-Jiménez, María Cristina López-Alados, Mariana F. Fernandez, Nicolás Olea
International Journal of Hygiene and Environmental Health, 2023
BACKGROUND: Perfluoroalkyl substances (PFAS) are found in a wide range of consumer products. Exposure to PFAS in children and adolescents may be associated with alterations in thyroid hormones, which have critical roles in brain function. OBJECTIVE: This study investigated the association between plasma concentrations of PFAS and serum levels of total triiodothyronine (T3), free thyroxine (T4), and thyroid-stimulating hormone (TSH) in adolescent males. METHODS: In 2017-2019, 151 boys from the Environment and Childhood (INMA)-Granada birth cohort, Spain, participated in a clinical follow up visit at the age of 15-17 years. Plasma concentrations of ten PFAS (PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFTrDA, PFOS, and PFHxS) and serum thyroid hormones were measured in 129 of these boys. Linear regression analysis was performed to determine associations of individual PFAS with total T3, free T4, TSH, and free T4/TSH ratio, and quantile g-computation models were performed to assess the mixture effect. Additional models considered iodine status as effect modifier. RESULTS: PFOS was the most abundant PFAS in plasma (median = 2.22 μg/L), followed by PFOA (median = 1.00 μg/L), PFNA (median = 0.41 μg/L), and PFHxS (median = 0.40 μg/L). When adjusted by confounders (including age, maternal schooling, and fish intake), PFOA and PFUnDA were associated with an increase in free T4 (β [95% CI] = 0.72 [0.06; 1.38] and 0.36 [0.04; 0.68] pmol/L, respectively, per two-fold increase in plasma concentrations), with no change in TSH. PFOS, the sum of PFOA, PFNA, PFOS, and PFHxS, and the sum of long-chain PFAS were marginally associated with increases in free T4. Associations with higher free T4 and/or total T3 were seen for several PFAS in boys with lower iodine intake (<108 μ/day) alone. Moreover, the PFAS mixture was association with an increase in free T4 levels in boys with lower iodine intake (% change [95% CI] = 6.47 [-0.69; 14.11] per each quartile increase in the mixture concentration). CONCLUSIONS: Exposure to PFAS, considered individually or as a mixture, was associated with an increase in free T4 levels in boys with lower iodine intake. However, given the small sample size, the extent of these alterations remains uncertain.
Kisspeptin as potential biomarker of environmental chemical mixture effect on reproductive hormone profile: A pilot study in adolescent males
Andrea Rodriguez-Carrillo, Sylvie Remy, Shereen Cynthia D'Cruz, Elena Salamanca-Fernandez, Fernando Gil, Pablo Olmedo, Vicente Mustieles, Fernando Vela-Soria, Kirsten Baken, Nicolás Olea, Fátima Smagulova, Mariana F. Fernandez, Carmen Freire
Science of the Total Environment, 2023
Kisspeptin has been proposed as an effect biomarker to understand the mechanisms by which some environmental chemicals adversely affect the human reproductive system. To ascertain whether kisspeptin serum protein and DNA methylation levels are associated with exposure to several environmental chemicals (individually and as a mixture) and serum reproductive hormone levels in adolescent males. Three phenols (bisphenol A [BPA], methyl-paraben [MPB], and benzophenone-3 [BP3]); two toxic metals (arsenic and cadmium); and four metabolites of non-persistent pesticides, including insecticides (2-isopropyl-6-methyl-4-pyrimidinol [IMPy], malathion diacid [MDA], and dimethylcyclopropane carboxylic acid [DCCA]) and fungicides (ethylene thiourea [ETU]) were measured in first-morning urine samples of 133 adolescent males aged 15–17 years from the INMA-Granada cohort. In blood samples collected on the same day, KISS1 gene DNA methylation was measured at four CpGs from the Exon IV, as well as serum levels of kiss54 protein, total testosterone (T), estradiol (E2), sex hormone binding-globulin, dehydroepiandrosterone sulfate, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). Multiple linear regression and mixture (quantile g-computation) models were fit. Urinary MDA and DCCA concentrations were associated with higher kiss54 levels [% change (95%CI) for each log-unit increase in concentration = 2.90 (0.32;5.56), and 1.93 (0.45,3.43), respectively]; IMPy with lower DNA methylation percentage at CpG1 and total CpGs [% change (95%CI) = −1.15 (−1.96;-0.33): −0.89 (−1.73;-0.01), respectively]; and BP3 and DCCA with lower total CpGs methylation [−0.53 (−1.04;-0.01) and − 0.69 (−1.37;-0.01), respectively]. The pesticide mixture and the whole chemical mixture were associated with higher kiss54 [% change (95%CI) = 9.09 (3.29;15.21) and 11.61 (3.96;19.82), respectively] and lower methylation levels at several CpGs. Additionally, serum kiss54 in the third tertile was associated with higher LH levels [% change (95%CI) = 28.69 (3.75–59.63)], and third-tertile CpG1, CpG2, and total CpG methylation percentages were associated with lower FSH and E2. The findings of the present study and the negative correlation between serum kiss54 levels and KISS1 DNA methylation percentages suggested that kisspeptin may be a promising effect biomarker.
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge
Andrea Rodríguez-Carrillo, Vicente Mustieles, Elena Salamanca-Fernández, Alicia Olivas-Martínez, Beatriz Suárez, Lola Bajard, Kirsten Baken, Ludek Blaha, Eva Cecilie Bonefeld-Jørgensen, Stephan Couderq, Shereen Cynthia D'Cruz, Jean-Baptiste Fini, Eva Govarts, Claudia Gundacker, Antonio F. Hernández, Marina Lacasaña, Federica Laguzzi, Birgitte Linderman, Manhai Long, Henriqueta Louro, Christiana Neophytou, Axel Oberemn, Sylvie Remy, Anna Kjerstine Rosenmai, Anne Thoustrup Saber, Greet Schoeters, Maria Joao Silva, Fatima Smagulova, Maria Uhl, Anne Marie Vinggaard, Ulla Vogel, Maria Wielsøe, Nicolás Olea, Mariana F. Fernández
International Journal of Hygiene and Environmental Health, 2023
Human biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are suspected to contribute to adverse health outcomes such as reproductive, neurological, and metabolic disorders, among other developmental and chronic impairments. One of the objectives of the H2020 European Human Biomonitoring Initiative (HBM4EU) was the development of informative effect biomarkers for application in a more systematic and harmonized way in large-scale European HBM studies. The inclusion of effect biomarkers would complement exposure data with mechanistically-based information on early and late adverse effects. For this purpose, a stepwise strategy was developed to identify and implement a panel of validated effect biomarkers in European HBM studies. This work offers an overview of the complete procedure followed, from comprehensive literature search strategies, selection of criteria for effect biomarkers and their classification and prioritization, based on toxicological data and adverse outcomes, to pilot studies for their analytical, physiological, and epidemiological validation. We present the example of one study that demonstrated the mediating role of the effect biomarker status of brain-derived neurotrophic factor BDNF in the longitudinal association between infant bisphenol A (BPA) exposure and behavioral function in adolescence. A panel of effect biomarkers has been implemented in the HBM4EU Aligned Studies as main outcomes, including traditional oxidative stress, reproductive, and thyroid hormone biomarkers. Novel biomarkers of effect, such as DNA methylation status of BDNF and kisspeptin (KISS) genes were also evaluated as molecular markers of neurological and reproductive health, respectively. A panel of effect biomarkers has also been applied in HBM4EU occupational studies, such as micronucleus analysis in lymphocytes and reticulocytes, whole blood comet assay, and malondialdehyde, 8-oxo-2'-deoxyguanosine and untargeted metabolomic profile in urine, to investigate, for example, biological changes in response to hexavalent chromium Cr(VI) exposure. The use of effect biomarkers in HBM4EU has demonstrated their ability to detect early biological effects of chemical exposure and to identify subgroups that are at higher risk. The roadmap developed in HBM4EU confirms the utility of effect biomarkers, and support one of the main objectives of HBM research, which is to link exposure biomarkers to mechanistically validated effect and susceptibility biomarkers in order to better understand the public health implications of human exposure to environmental chemicals.
Development and validation of brain-derived neurotrophic factor measurement in human urine samples as a non-invasive effect biomarker
Alicia Olivas-Martinez, Beatriz Suarez, Elena Salamanca-Fernandez, Iris Reina-Perez, Andrea Rodriguez-Carrillo, Vicente Mustieles, Nicolás Olea, Carmen Freire, Mariana F. Fernández
Frontiers in Molecular Neuroscience, 2023
BackgroundBrain-derived neurotrophic factor (BDNF), a neurotrophic growth factor mainly expressed in the brain, has been proposed as a potential effect biomarker; that is, as a measurable biomarker whose values could be associated with several diseases, including neurological impairments. The European Human Biomonitoring Initiative (HBM4EU) has also recognized effect biomarkers as a useful tool for establishing link between exposure to environmental pollutants and human health. Despite the well-establish protocol for measuring serum BDNF, there is a need to validate its assessment in urine, a non-invasive sample that can be easily repeated over time. The aim of this study was to develop, standardize and validate a methodology to quantify BDNF protein levels in urine samples before its implementation in biomonitoring studies.MethodsDifferent experimental conditions and non-competitive commercial enzyme-linked immunosorbent assay (ELISA) kits were tested to determine the optimal analytical procedure, trying to minimize the shortcomings of ELISA kits. The fine-tune protocol was validated in a pilot study using both upon awakening (n = 150) and prior to sleeping (n = 106) urine samples from the same Spanish adolescent males in a well-characterized study population (the Spanish INMA-Granada cohort).ResultsThe best results were obtained in 0.6 ml of urine after the acidification and extraction (pre-concentration) of samples. The highest reproducibility was obtained with the ELISA kit from Raybiotech. Urinary BDNF concentrations of adolescent males were within the previously reported range (morning = 0.047–6.801 ng/ml and night = 0.047–7.404 ng/ml). Urinary BDNF levels in the awakening and pre-sleep samples did not follow a normal distribution and were not correlated.ConclusionThe developed methodology offers good sensitivity and reproducibility. Having reliable markers in urine may facilitate both diagnosis and monitoring possible diseases (and treatment). Further studies are needed to implement urinary BDNF in biomonitoring studies to further elucidate its usefulness and biological significance for neurological impairments.
The Mixture of Bisphenol-A and Its Substitutes Bisphenol-S and Bisphenol-F Exerts Obesogenic Activity on Human Adipose-Derived Stem Cells
Iris Reina-Pérez, Alicia Olivas-Martínez, Vicente Mustieles, Elena Salamanca-Fernández, José Manuel Molina-Molina, Nicolás Olea, Mariana F. Fernández
Toxics, 2022
Bisphenol A (BPA) and its substitutes, bisphenol F (BPF) and S (BPS), have previously shown in vitro obesogenic activity. This study was designed to investigate their combined effect on the adipogenic differentiation of human adipose-derived stem cells (hASCs). Cells were exposed for 14 days to an equimolar mixture of bisphenols (MIX) (range 10 nM–10 µM). Oil Red staining was used to measure intracellular lipid accumulation, quantitative real-time polymerase chain reaction (qRT-PCR) to study gene expression of adipogenic markers (PPARγ, C/EBPα, LPL, and FABP4), and Western Blot to determine their corresponding proteins. The MIX promoted intracellular lipid accumulation in a dose-dependent manner with a maximal response at 10 µM. Co-incubation with pure antiestrogen (ICI 182,780) inhibited lipid accumulation, suggesting that the effect was mediated by the estrogen receptor. The MIX also significantly altered the expression of PPARγ, C/EBPα, LPL, and FABP4 markers, observing a non-monotonic (U-shaped) dose-response, with maximal gene expression at 10 nM and 10 µM and lesser expression at 1 µM. This pattern was not observed when bisphenols were tested individually. Exposure to MIX (1–10 µM) also increased all encoded proteins except for FABP4, which showed no changes. Evaluation of the combined effect of relevant chemical mixtures is needed rather than single chemical testing.
Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study
Elena Salamanca-Fernández, Miguel Rodríguez-Barranco, Pilar Amiano, Josu Delfrade, Maria Dolores Chirlaque, Sandra Colorado, Marcela Guevara, Ana Jimenez, Juan Pedro Arrebola, Fernando Vela, Nicolás Olea, Antonio Agudo, Maria-José Sánchez
Environmental Health A Global Access Science Source, 2021
BackgroundBisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. The aim of this study was to assess the potential association of serum BPA concentrations and the risk of incident breast and prostate cancer in a sub-cohort of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsWe designed a case-cohort study within the EPIC-Spain cohort. Study population consisted on 4812 participants from 4 EPIC-Spain centers (547 breast cancer cases, 575 prostate cancer cases and 3690 sub-cohort participants). BPA exposure was assessed by means of chemical analyses of serum samples collected at recruitment. Borgan II weighted Cox regression was used to estimate hazard ratios.ResultsMedian follow-up time in our study was 16.9 years. BPA geometric mean serum values of cases and sub-cohort were 1.12 ng/ml vs 1.10 ng/ml respectively for breast cancer and 1.33 ng/ml vs 1.29 ng/ml respectively for prostate cancer. When categorizing BPA into tertiles, a 40% increase in risk of prostate cancer for tertile 1 (p = 0.022), 37% increase for tertile 2 (p = 0.034) and 31% increase for tertile 3 (p = 0.072) was observed with respect to values bellow the limit of detection. No significant association was observed between BPA levels and breast cancer risk.ConclusionsWe found a similar percentage of detection of BPA among cases and sub-cohort from our population, and no association with breast cancer risk was observed. However, we found a higher risk of prostate cancer for the increase in serum BPA levels. Further investigation is needed to understand the influence of BPA in prostate cancer risk.
Inflammatory potential of the diet and incidence of crohn’s disease and ulcerative colitis in the EPIC-Spain cohort
Marcela Guevara, Elena Salamanca-Fernández, Estrella Miqueleiz, Diana Gavrila, Pilar Amiano, Catalina Bonet, Miguel Rodríguez-Barranco, José María Huerta, Luis Bujanda, María José Sánchez, María Dolores Chirlaque, Antonio Agudo, Eva Ardanaz, Jesús Castilla
Nutrients, 2021
Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn’s disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29–69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05–2.80; p = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66–1.19; p = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.
Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis
Sandra M. Colorado-Yohar, Ana C. Castillo-González, Julio Sánchez-Meca, María Rubio-Aparicio, Diego Sánchez-Rodríguez, Elena Salamanca-Fernández, Eva Ardanaz, Pilar Amiano, Mariana F. Fernández, Jaime Mendiola, Fernando Navarro-Mateu, María Dolores Chirlaque
Science of the Total Environment, 2021
Safety considerations during prescription of non-steroidal anti-inflammatory drugs (Nsaids), through a review of systematic reviews
A. Olry de Labry Lima, E. Salamanca-Fernández, E. J. Alegre del Rey, A. Matas Hoces, M. Á. G. González Vera, C. Bermúdez Tamayo
Anales Del Sistema Sanitario De Navarra, 2021
Study protocol on Socioeconomic and Geographic Inequalities in Cancer Incidence, Mortality and Survival in Spain: Multilevel Population-Base Study: DESOCANES study
Miguel Ángel Luque-Fernández, Daniel Redondo-Sánchez, Pablo Fernández, Elena Salamanca-Fernández, Rafael Marcos-Gragera, Marcela Guevara, Marià Carulla Aresté, Rosario Jiménez, Olivier Núñez, Consol Sabater, Arantxa López de Munain Marqués, María Dolores Chirlaque, Antonio Mateos, Miguel Rodríguez-Barranco, Jaime Espín Balbino, Marina Pollán, María-José Sánchez
Gaceta Sanitaria, 2021
Serum levels of non-persistent environmental pollutants and risk of incident hypertension in a sub-cohort from the EPIC study
E. Salamanca-Fernández, F. Vela-Soria, M. Rodríguez-Barranco, A. Arrebola-Moreno, L.M. Iribarne-Durán, N. Olea, M.J. Sánchez, J.P. Arrebola
Environmental Research, 2021
Greenhouse gases emissions from the diet and risk of death and chronic diseases in the EPIC-Spain cohort
Carlos A González, Catalina Bonet, Miguel de Pablo, María José Sanchez, Elena Salamanca-Fernandez, Miren Dorronsoro, Pilar Amiano, Jose María Huerta, María Dolores Chirlaque, Eva Ardanaz, Aurelio Barricarte, Jose Ramón Quirós, Antonio Agudo, Marta Guadalupe Rivera Ferrer
European Journal of Public Health, 2021
Influence of environmental temperature and air pollution on the transmission of SARS-CoV-2
Revista Espanola De Salud Publica, 2021
Bisphenol A exposure and risk of ischemic heart disease in the Spanish European Prospective Investigation into cancer and nutrition study
Elena Salamanca-Fernández, Miguel Rodríguez-Barranco, Dafina Petrova, Nerea Larrañaga, Marcela Guevara, Conchi Moreno-Iribas, Maria Dolores Chirlaque, Sandra Colorado-Yohar, Juan Pedro Arrebola, Fernando Vela, Nicolás Olea, Antonio Agudo, Maria-José Sánchez
Chemosphere, 2020
Relationship between exposure to mixtures of persistent, bioaccumulative, and toxic chemicals and cancer risk: A systematic review
Nicolás Francisco Fernández-Martínez, Ana Ching-López, Antonio Olry de Labry Lima, Elena Salamanca-Fernández, Beatriz Pérez-Gómez, José Juan Jiménez-Moleón, Maria José Sánchez, Miguel Rodríguez-Barranco
Environmental Research, 2020
Obesity as a risk factor in COVID-19: Possible mechanisms and implications
Dafina Petrova, Elena Salamanca-Fernández, Miguel Rodríguez Barranco, Pilar Navarro Pérez, José Juan Jiménez Moleón, Maria-José Sánchez
Atencion Primaria, 2020
The impact of plant‐based dietary patterns on cancer‐related outcomes: A rapid review and meta‐analysis
Esther Molina-Montes, Elena Salamanca-Fernández, Belén Garcia-Villanova, Maria José Sánchez
Nutrients, 2020
Historical exposure to non-persistent environmental pollutants and risk of type 2 diabetes in a Spanish sub-cohort from the European Prospective Investigation into Cancer and Nutrition study
E. Salamanca-Fernández, L.M. Iribarne-Durán, M. Rodríguez-Barranco, F. Vela-Soria, N. Olea, M.J. Sánchez-Pérez, J.P. Arrebola
Environmental Research, 2020
Psychological factors related to time to help-seeking for cancer symptoms: a meta-analysis across cancer sites
Dafina Petrova, Yasmina Okan, Elena Salamanca-Fernández, Santiago Domínguez-López, María-José Sánchez, Miguel Rodríguez-Barranco
Health Psychology Review, 2020
Multimorbidity and short-term overall mortality among colorectal cancer patients in Spain: A population-based cohort study
Miguel A. Luque-Fernandez, Karen Gonçalves, Elena Salamanca-Fernández, Daniel Redondo-Sanchez, Shing F. Lee, Miguel Rodríguez-Barranco, Ma C. Carmona-García, Rafael Marcos-Gragera, María-José Sánchez
European Journal of Cancer, 2020
Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors
Elena Salamanca-Fernández, Miguel Rodríguez-Barranco, Juan Pedro Arrebola, Fernando Vela, Caridad Díaz, María Dolores Chirlaque, Sandra Colorado-Yohar, Ana Jiménez-Zabala, Amaia Irizar, Marcela Guevara, Eva Ardanaz, Luz María Iribarne-Durán, José Pérez del Palacio, Nicolás Olea, Antonio Agudo, Maria-José Sánchez
Environmental Research, 2020
Socioeconomic inequalities in colorectal cancer survival in Southern Spain: A multilevel population-based cohort study
Miguel Angel Luque-Fernandez, Daniel Redondo-Sanchez, Miguel Rodriguez-Barranco, Chang-Chan Yoe-Ling, Elena Salamanca-Fernandez, Olivier Nunez, Pablo Fernandez-Navarro, Marina Pollan, Maria-Jose Sanchez
Clinical Epidemiology, 2020
Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Raul Zamora-Ros, Muath A. Alghamdi, Valerie Cayssials, Silvia Franceschi, Martin Almquist, Joakim Hennings, Maria Sandström, Konstantinos K. Tsilidis, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina E. N. Petersen, Francesca Romana Mancini, Yahya Mahamat-Saleh, Fabrice Bonnet, Tilman Kühn, Renée T. Fortner, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Georgia Martimianaki, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Francesca Fasanelli, Guri Skeie, Tonje Braaten, Cristina Lasheras, Elena Salamanca-Fernández, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Peter Wallström, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Kay-Thee Khaw, Nicholas J. Wareham, Julie A. Schmidt, Dagfinn Aune, Graham Byrnes, Augustin Scalbert, Antonio Agudo, Sabina Rinaldi
European Journal of Nutrition, 2019
Estimated Substitution of Tea or Coffee for Sugar-Sweetened Beverages Was Associated with Lower Type 2 Diabetes Incidence in Case-Cohort Analysis across 8 European Countries in the EPIC-InterAct Study
Fumiaki Imamura, Matthias B Schulze, Stephen J Sharp, Marcela Guevara, Dora Romaguera, Benedetta Bendinelli, Elena Salamanca-Fernández, Eva Ardanaz, Larraitz Arriola, Dagfinn Aune, Heiner Boeing, Courtney Dow, Guy Fagherazzi, Paul W Franks, Heinz Freisling, Paula Jakszyn, Rudolf Kaaks, Kay-Tee Khaw, Tilman Kühn, Francesca R Mancini, Giovanna Masala, Maria-Dolores Chirlaque, Peter M Nilsson, Kim Overvad, Valeria M Pala, Salvatore Panico, Aurora Perez-Cornago, Jose R Quirós, Fulvio Ricceri, Miguel Rodríguez-Barranco, Olov Rolandsson, Ivonne Sluijs, Magdalena Stepien, Annemieke M W Spijkerman, Anne Tjønneland, Tammy Y N Tong, Rosario Tumino, Linda E T Vissers, Heather A Ward, Claudia Langenberg, Elio Riboli, Nita G Forouhi, Nick J Wareham
Journal of Nutrition, 2019
Contribution of sociodemographic, occupational, lifestyle and dietary characteristics to the oxidative stress microenvironment in adipose tissue
Josefa León, José M. Sáenz, Francisco Artacho-Cordón, Mariana F. Fernández, Piedad Martin-Olmedo, Elena Salamanca-Fernández, Celia Gómez-Peña, Nicolás Olea, Juan P. Arrebola
Environmental Research, 2019
Association of menopausal characteristics and risk of coronary heart disease: A pan-European case-cohort analysis
Veerle Dam, Yvonne T van der Schouw, N Charlotte Onland-Moret, Rolf H H Groenwold, Sanne A E Peters, Stephen Burgess, Angela M Wood, Maria-Dolores Chirlaque, Karel G M Moons, Clare Oliver-Williams, Ewoud Schuit, Kaja Tikk, Elisabete Weiderpass, Marianne Holm, Anne Tjønneland, Tilman Kühn, Renée T Fortner, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Pietro Ferrari, Marc Gunter, Giovanna Masala, Sabina Sieri, Rosario Tumino, Salvatore Panico, Jolanda M A Boer, W M Monique Verschuren, Elena Salamanca-Fernández, Larraitz Arriola, Conchi Moreno-Iribas, Gunnar Engström, Olle Melander, Maria Nordendahl, Patrik Wennberg, Timothy J Key, Sandra Colorado-Yohar, Giuseppe Matullo, Kim Overvad, Francoise Clavel-Chapelon, Heiner Boeing, J Ramon Quiros, Emanuele di Angelantonio, Claudia Langenberg, Michael J Sweeting, Elio Riboli, Nicholas J Wareham, John Danesh, Adam Butterworth
International Journal of Epidemiology, 2019
Patient, tumor, and healthcare factors associated with regional variability in lung cancer survival: a Spanish high-resolution population-based study
M. Rodríguez-Barranco, E. Salamanca-Fernández, M. L. Fajardo, E. Bayo, Y.-L. Chang-Chan, J. Expósito, C. García, J. Tallón, P. Minicozzi, M. Sant, D. Petrova, M. A. Luque-Fernandez, M.-J. Sánchez
Clinical and Translational Oncology, 2019
Association of plasma Vitamin D metabolites with incident type 2 diabetes: EPIC-InterAct case-cohort study
Ju-Sheng Zheng, Fumiaki Imamura, Stephen J Sharp, Yvonne T van der Schouw, Ivonne Sluijs, Thomas E Gundersen, Eva Ardanaz, Heiner Boeing, Catalina Bonet, Jesus Humberto Gómez, Courtney Dow, Guy Fagherazzi, Paul W Franks, Mazda Jenab, Tilman Kühn, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Cristina Lasheras, Olatz Mokoroa, Francesca Romana Mancini, Peter M Nilsson, Kim Overvad, Salvatore Panico, Domenico Palli, Olov Rolandsson, Sabina Sieri, Elena Salamanca-Fernández, Carlotta Sacerdote, Annemieke M W Spijkerman, Magdalena Stepien, Anne Tjonneland, Rosario Tumino, Adam S Butterworth, Elio Riboli, John Danesh, Claudia Langenberg, Nita G Forouhi, Nicholas J Wareham
Journal of Clinical Endocrinology and Metabolism, 2019
Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition
Crystal Lin, Ruth C. Travis, Paul N. Appleby, Sarah Tipper, Elisabete Weiderpass, Jenny Chang‐Claude, Inger T. Gram, Rudolf Kaaks, Lambertus A. Kiemeney, Börje Ljungberg, Rosario Tumino, Anne Tjønneland, Nina Roswall, Kim Overvad, Marie‐Christine Boutron‐Ruault, Francesca Romana Manciniveri, Gianluca Severi, Antonia Trichopoulou, Giovanna Masala, Carlotta Sacerdote, Claudia Agnoli, Salvatore Panico, Bas Bueno‐de‐Mesquita, Petra H. Peeters, Elena Salamanca‐Fernández, Maria‐Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Virginia Menéndez, Leila Luján‐Barroso, Fredrik Liedberg, Heinz Freisling, Marc Gunter, Dagfinn Aune, Amanda J. Cross, Elio Riboli, Timothy J. Key, Aurora Perez‐Cornago
International Journal of Cancer, 2018
How are risk ratios reported in orthopaedic surgery journals? A descriptive study of formats used to report absolute risks
Dafina Petrova, Alexander Joeris, María-José Sánchez, Elena Salamanca-Fernández, Rocio Garcia-Retamero
BMJ Open, 2018
Thyroid Cancer Epidemiology in South Spain: a population-based time trend study
Elena Salamanca-Fernández, Miguel Rodriguez-Barranco, Yoe-Ling Chang-Chan, Daniel Redondo-Sánchez, Santiago Domínguez-López, Eloísa Bayo, Dariusz Narankiewicz, José Expósito, María José Sánchez
Endocrine, 2018
The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: Analysis from the EPIC-Spain sub-cohort
Leila Lujan‐Barroso, Karina Gibert, Mireia Obón‐Santacana, María Dolores Chirlaque, María‐Jose Sánchez, Nerea Larrañaga, Aurelio Barricarte, Jose Ramón Quirós, Elena Salamanca‐Fernández, Sandra Colorado‐Yohar, Basilio Gómez‐Pozo, Antonio Agudo, Eric J Duell
American Journal of Human Biology, 2018
Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study
Mélanie Deschasaux, Inge Huybrechts, Neil Murphy, Chantal Julia, Serge Hercberg, Bernard Srour, Emmanuelle Kesse-Guyot, Paule Latino-Martel, Carine Biessy, Corinne Casagrande, Mazda Jenab, Heather Ward, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Cecilie Kyrø, Anja Olsen, Aurélie Affret, Marie-Christine Boutron-Ruault, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Lukas Schwingshackl, Christina Bamia, Eleni Peppa, Antonia Trichopoulou, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Petra H. Peeters, Anette Hjartåker, Charlotta Rylander, Guri Skeie, J. Ramón Quirós, Paula Jakszyn, Elena Salamanca-Fernández, José María Huerta, Eva Ardanaz, Pilar Amiano, Ulrika Ericson, Emily Sonestedt, Ena Huseinovic, Ingegerd Johansson, Kay-Tee Khaw, Nick Wareham, Kathryn E. Bradbury, Aurora Perez-Cornago, Konstantinos K. Tsilidis, Pietro Ferrari, Elio Riboli, Marc J. Gunter, Mathilde Touvier
Plos Medicine, 2018
Prediction of acute myeloid leukaemia risk in healthy individuals
Sagi Abelson, Grace Collord, Stanley W. K. Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C. Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Iulia Cirlan, Trevor J. Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D. McPherson, Mattias Johansson, Faridah Mbabaali, Jenna Eagles, Jessica K. Miller, Danielle Pasternack, Lee Timms, Paul Krzyzanowski, Philip Awadalla, Rui Costa, Eran Segal, Scott V. Bratman, Philip Beer, Sam Behjati, Inigo Martincorena, Jean C. Y. Wang, Kristian M. Bowles, J. Ramón Quirós, Anna Karakatsani, Carlo La Vecchia, Antonia Trichopoulou, Elena Salamanca-Fernández, José M. Huerta, Aurelio Barricarte, Ruth C. Travis, Rosario Tumino, Giovanna Masala, Heiner Boeing, Salvatore Panico, Rudolf Kaaks, Alwin Krämer, Sabina Sieri, Elio Riboli, Paolo Vineis, Matthieu Foll, James McKay, Silvia Polidoro, Núria Sala, Kay-Tee Khaw, Roel Vermeulen, Peter J. Campbell, Elli Papaemmanuil, Mark D. Minden, Amos Tanay, Ran D. Balicer, Nicholas J. Wareham, Moritz Gerstung, John E. Dick, Paul Brennan, George S. Vassiliou, Liran I. Shlush
Nature, 2018
Circulating fetuin - A and risk of type 2 diabetes: A mendelian randomization analysis
Janine Kröger, Karina Meidtner, Norbert Stefan, Marcela Guevara, Nicola D. Kerrison, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Paul W. Franks, Heinz Freisling, Marc J. Gunter, José María Huerta, Rudolf Kaaks, Timothy J. Key, Kay Tee Khaw, Vittorio Krogh, Tilman Kühn, Francesca Romana Mancini, Amalia Mattiello, Peter M. Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, J. Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Núria Sala, Elena Salamanca-Fernández, Ivonne Sluijs, Annemieke M.W. Spijkerman, Anne Tjonneland, Konstantinos K. Tsilidis, Rosario Tumino, Yvonne T. van der Schouw, Nita G. Forouhi, Stephen J. Sharp, Claudia Langenberg, Elio Riboli, Matthias B. Schulze, Nicholas J. Wareham
Diabetes, 2018
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh, Angela M Wood, Stephen Kaptoge, Adam Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Salomaa Veikko, Børge G Nordestgaard, Bu B Yeap, Astrid Flecther, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela Bergmann, Carlos Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M.A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J. Ramon Quiros, Eric B Rimm, Rosario Tumino, Dan G Blazer III, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Veikko Salomaa, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean-Pierre Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillumn, Ian Ford Ford, Naveed Sattar, Mariana Lazo, Simon Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
Lancet, 2018
Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Raul Zamora‐Ros, Virginie Béraud, Silvia Franceschi, Valerie Cayssials, Konstantinos K. Tsilidis, Marie‐Christine Boutron‐Ruault, Elisabete Weiderpass, Kim Overvad, Anne Tjønneland, Anne K. Eriksen, Fabrice Bonnet, Aurélie Affret, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elisavet Valanou, Anna Karakatsani, Giovanna Masala, Sara Grioni, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Guri Skeie, Christine L Parr, Susana Merino, Elena Salamanca‐Fernández, Maria‐Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Martin Almquist, Isabel Drake, Joakim Hennings, Maria Sandström, H. B(as) Bueno‐de‐Mesquita, Petra H. Peeters, Kay‐Thee Khaw, Nicholas J. Wareham, Julie A. Schmidt, Aurora Perez‐Cornago, Dagfinn Aune, Elio Riboli, Nadia Slimani, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Sabina Rinaldi
International Journal of Cancer, 2018
Night-shift work and breast and prostate cancer risk: Updating the evidence from epidemiological studies
Elena Salamanca‐Fernández, Miguel Rodríguez‐Barranco, Marcela Guevara, Eva Ardanáz, Antonio Olry de Labry Lima, et al.
Anales Del Sistema Sanitario De Navarra, 2018
Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study
Raul Zamora-Ros, Jazmín Castañeda, Sabina Rinaldi, Valerie Cayssials, Nadia Slimani, Elisabete Weiderpass, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Kim Overvad, Anne K Eriksen, Anne Tjønneland, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Carlo La Vecchia, Anastasia Kotanidou, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Veronica Sciannameo, Eiliv Lund, Susana Merino, Elena Salamanca-Fernández, Pilar Amiano, José María Huerta, Aurelio Barricarte, Ulrika Ericson, Martin Almquist, Joakim Hennings, Maria Sandström, H Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Tee Khaw, Nicholas J Wareham, Julie A Schmidt, Amanda J Cross, Elio Riboli, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Silvia Franceschi
Journal of Nutrition, 2017
Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition
Saverio Caini, Giovanna Masala, Calogero Saieva, Marina Kvaskoff, Isabelle Savoye, Carlotta Sacerdote, Oskar Hemmingsson, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina E.N. Petersen, Francesca Romana Mancini, Marie-Christine Boutron-Ruault, Iris Cervenka, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Anna Floegel, Antonia Trichopoulou, Elisavet Valanou, Maria Kritikou, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Marit B. Veierød, Reza Ghiasvand, Marko Lukic, José Ramón Quirós, Maria-Dolores Chirlaque, Eva Ardanaz, Elena Salamanca Fernández, Nerea Larrañaga, Raul Zamora-Ros, Lena Maria Nilsson, Ingrid Ljuslinder, Karin Jirström, Emily Sonestedt, Timothy J. Key, Nick Wareham, Kay-Tee Khaw, Marc Gunter, Inge Huybrechts, Neil Murphy, Konstantinos K. Tsilidis, Elisabete Weiderpass, Domenico Palli
International Journal of Cancer, 2017
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
EPIC-InterAct Consortium, Luca A Lotta, Cambridge FPLD1 Consortium, Pawan Gulati, Felix R Day, Felicity Payne, Halit Ongen, Martijn van de Bunt, Kyle J Gaulton, John D Eicher, Stephen J Sharp, Jian'an Luan, Emanuella De Lucia Rolfe, Isobel D Stewart, Eleanor Wheeler, Sara M Willems, Claire Adams, Hanieh Yaghootkar, Nita G Forouhi, Kay-Tee Khaw, Andrew D Johnson, Robert K Semple, Timothy Frayling, John R B Perry, Emmanouil Dermitzakis, Mark I McCarthy, Inês Barroso, Nicholas J Wareham, David B Savage, Claudia Langenberg, Stephen O'Rahilly, Robert A Scott
Nature Genetics, 2017
Determination of personal care products –benzophenones and parabens– in human menstrual blood
I. Jiménez-Díaz, L.M. Iribarne-Durán, O. Ocón, E. Salamanca, M.F. Fernández, N. Olea, E. Barranco
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2016
Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: A meta-analysis
Luca A. Lotta, Stephen J. Sharp, Stephen Burgess, John R. B. Perry, Isobel D. Stewart, Sara M. Willems, Jian’an Luan, Eva Ardanaz, Larraitz Arriola, Beverley Balkau, Heiner Boeing, Panos Deloukas, Nita G. Forouhi, Paul W. Franks, Sara Grioni, Rudolf Kaaks, Timothy J. Key, Carmen Navarro, Peter M. Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, Jose-Ramón Quirós, Elio Riboli, Olov Rolandsson, Carlotta Sacerdote, Elena Salamanca-Fernandez, Nadia Slimani, Annemieke M. W. Spijkerman, Anne Tjonneland, Rosario Tumino, Daphne L. van der A, Yvonne T. van der Schouw, Mark I. McCarthy, Inês Barroso, Stephen O’Rahilly, David B. Savage, Naveed Sattar, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham
JAMA Journal of the American Medical Association, 2016
Serum and adipose tissue as matrices for assessment of exposure to persistent organic pollutants in breast cancer patients
F. Artacho-Cordón, M. Fernández-Rodríguez, C. Garde, E. Salamanca, L.M. Iribarne-Durán, P. Torné, J. Expósito, L. Papay-Ramírez, M.F. Fernández, N. Olea, J.P. Arrebola
Environmental Research, 2015

Elena Salamanca-Fernandez

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