Comment on “Renal and cardiovascular effects of SGLT2 inhibitors among hypertensive patients with chronic kidney disease: A systematic review and meta-analysis” Sushma Verma, Prashant Ramdas Kokiwar, Varshini Vadhithala, Dinesh Puri International Journal of Cardiology Cardiovascular Risk and Prevention, 2026 Comment on "Renal and cardiovascular effects of SGLT2 inhibitors among hypertensive patients with chronic kidney disease: A systematic review and meta-analysis" Dear Editor,We read with interest this systematic review and meta-analysis evaluating SGLT2 inhibitors in hypertensive chronic kidney disease [1].The study addresses an important clinical question and reports reduced risks of renal progression, cardiovascular events, and serious adverse events, supporting broader cardiorenal use in this high-risk population.A key methodological issue concerns search transparency and reproducibility.Although multiple databases were reportedly searched, the study flow numerically accounts only for PubMed and ClinicalTrials.gov, which makes the complete search difficult to verify.In addition, the pooled "hypertensive" subgroup appears clinically heterogeneous, combining blood pressure based definitions with trial-defined hypertension or antihypertensive treatment.This matters because contemporary evidence suggests that SGLT2 benefits vary in absolute magnitude according to baseline CKD risk, albuminuria, and diabetes status [1,2].A related concern is subgroup interpretation.Recent evidence from the same journal indicates that SGLT2 inhibitors produce only modest blood pressure reductions, suggesting that the observed renal benefit may not map cleanly onto a hypertension-defined subgroup alone [3].Clarification of denominator discrepancies, subgroup ascertainment, and presentation of absolute risk differences would therefore strengthen interpretation, especially because large contemporary meta-analyses show broad renal benefit across eGFR, albuminuria, and diabetes strata [4,5].Addressing these points would improve interpretability and help clinicians apply these findings more precisely in practice.
Comment on “Trajectory pattern of serum urea nitrogen to creatinine ratio in acute kidney injury requiring continuous renal replacement therapy: A post hoc analysis of a … C Maji, PR Kokiwar, A Biradar, R Jauhari Journal of Critical Care 94, 155570 , 2026 2026 Citations: 1
Comment on “Integrating geriatric expertise into multidisciplinary tumour boards for older adults with colorectal cancer: a pragmatic real-world cohort study” S Padhi, PR Kokiwar, J Patel, A Kalra Journal of Geriatric Oncology 17 (5) , 2026 2026
Comment on “Determining size in an era when size matters: Interobserver comparison of CT lung tumor size measurements and accuracy of radiologic size estimation compared to … S Padhi, PR Kokiwar, J Patel, A Kalra Clinical Imaging 134 , 2026 2026
Comment on" Neurocognitive performance in myelin oligodendrocyte glycoprotein antibody-associated disease: A systematic review and meta-analysis" S Padhi, PR Kokiwar, J Patel, A Kalra Multiple Sclerosis and Related Disorders 110 , 2026 2026
Letter to the editor regarding “Efficacy and safety of lenvatinib as adjuvant therapy for hepatocellular carcinoma with vascular invasion after curative resection” S Padhi, PR Kokiwar, J Patel, A Kalra Journal of Gastrointestinal Surgery 30 (6) , 2026 2026
Letter to the Editor re:" Postobstructive diuresis and its biochemical characteristics in children undergoing pyeloplasty for unilateral pelviureteric junction obstruction-a … S Padhi, PR Kokiwar, J Patel, A Kalra Journal of Pediatric Urology , 2026 2026
letter P Kokiwar 2026
Comment on" Efficacy and Safety of Combination Therapy With Low Dose of Telmisartan and S-Amlodipine in Patients With Hypertension: A Randomized, Double-Blind, Multicenter … S Padhi, PR Kokiwar, J Patel, A Kalra Clinical therapeutics, S0149-2918 (26) 00105-0 , 2026 2026
Comment on" Mechanical circulatory assist devices stroke subtype classification: A novel stroke classification system in patients with ventricular assist devices" S Padhi, PR Kokiwar, J Patel, A Kalra Journal of Stroke and Cerebrovascular Diseases 35 (5) , 2026 2026
Comment on" Factors associated with dropout from health facility childbirth after antenatal care booking in Ethiopia: A systematic review and meta-analysis" S Padhi, PR Kokiwar, J Patel, A Kalra Sexual & reproductive healthcare: official journal of the Swedish … , 2026 2026
Comment on" Suicide risk and influencing factors among cancer patients: A mixed-methods study" S Verma, PR Kokiwar, V Vadhithala, D Puri European journal of oncology nursing: the official journal of European … , 2026 2026
Comment on" The effect of end-tidal carbon dioxide levels on dynamic cerebral autoregulation and clinical outcome in acute ischemic stroke: An INFOMATAS study" S Padhi, PR Kokiwar, J Patel, A Kalra Journal of the neurological sciences 486, 125967 , 2026 2026
Comment on “Electrolytes in Muscle Pain: Systematic Review and Meta-Analysis with Implications for TMD” S Padhi, PR Kokiwar, J Patel, A Kalra International Dental Journal 76 (4), 109599 , 2026 2026
Comment on" Exploring the role of left atrial fibrosis and left atrial volume index through cardiac magnetic resonance imaging in embolic stroke of undetermined source: A … B Tyagi, PR Kokiwar, A Dhyani Indian heart journal, S0019-4832 (26) 00073-8 , 2026 2026
Comment on “Renal memory in the Glenn-Fontan acute kidney injury continuum: A window for early renal protection” S Padhi, PR Kokiwar, J Patel, A Kalra Progress in Pediatric Cardiology, 101928 , 2026 2026
Comment on “Renal and cardiovascular effects of SGLT2 inhibitors among hypertensive patients with chronic kidney disease: A systematic review and meta-analysis” S Verma, PR Kokiwar, V Vadhithala, D Puri International Journal of Cardiology. Cardiovascular Risk and Prevention 29 … , 2026 2026
Comment on" Evaluation of P-wave dispersion in febrile patients presenting to the emergency department: A single-center prospective study" S Verma, PR Kokiwar, V Vadhithala, D Puri Journal of electrocardiology 97, 154258 , 2026 2026
Comment on “Diagnostic accuracy and limitations of intravoxel incoherent motion diffusion-weighted imaging for differentiating breast tumors: A systematic review and meta-analysis” AK Gupta, PR Kokiwar, J Patel, A Dhyani Clinical Imaging 132 , 2026 2026
Interpreting quality assessments of breast cancer screening videos on TikTok C Maji, PR Kokiwar, A Biradar, R Jauhari Clinical Imaging 132 , 2026 2026
Comment on ‘Feasibility Study Exploring the Effect of Pelvic Radiotherapy on the Intestinal Microbiome and Metabolome to Improve the Detection and Management of … C Maji, PR Kokiwar, A Biradar, R Jauhari Clinical Oncology 52 , 2026 2026
MOST CITED SCHOLAR PUBLICATIONS
Prevalence of hypertension in a rural community of central India PR Kokiwar, SS Gupta, PM Durge J Assoc Physicians India 60 (6), 26-9 , 2012 2012 Citations: 165
Nutritional status of adolescent girls from an urban slum area in South India K Prashant, C Shaw The Indian Journal of Pediatrics 76 (5), 501-504 , 2009 2009 Citations: 93
Prevalence of substance use among male adolescents in an urban slum area of Karimnagar district, Andhra Pradesh PR Kokiwar, GRS Jogdand Indian journal of public health 55 (1), 42-45 , 2011 2011 Citations: 77
Prevalence of diabetes in a rural area of central India PR Kokiwar, S Gupta, PM Durge Int J Diab Dev Ctries 27 (1), 8-10 , 2007 2007 Citations: 73
Knowledge and food hygiene practices among food handlers in food establishments SR Kubde, J Pattankar, PR Kokiwar Int J Community Med Public Health 3 (1), 251-6 , 2016 2016 Citations: 72
A study on prevalence and correlates of depression among elderly population of rural South India P Chauhan, PR Kokiwar, K Shridevi, S Katkuri Int J Community Med Public Health 3 (1), 236-239 , 2016 2016 Citations: 70
A cross sectional study of prevalence of substance use and its determinants among male tribal youths D Kangule, M Darbastwar, P Kokiwar Int J Pharm Biomed Sci 2 (3), 61-64 , 2011 2011 Citations: 29
A study of prevalence of childhood obesity among school children in Karimnagar town VA Katta, PR Kokiwar MRIMS Journal of health sciences 1 (1), 8-11 , 2013 2013 Citations: 19
search this publication PR Kokiwar, HB Kumar, A Mubashare Journal of Cancer Research and Therapeutics 7 (1), 95-95 , 2011 2011 Citations: 18
Health status of elderly: a comparative study among urban and rural dwellers VR, Zare., PR, Kokiwar., B, Ramesh. International Journal of Community Medicine and Public Health 5 (7), 3039-44 , 2018 2018 Citations: 17
Effect of smoking on PEFR: a comparative study among smokers and non smokers in an urban slum community of Hyderabad, India GV Sawant, SR Kubde, PR Kokiwar Int J Community Med Public Health 3 (1), 246-50 , 2016 2016 Citations: 16
Quality of life of women with breast cancer at a tertiary care hospital K Kannan, PR Kokiwar, S Jogdand Gopal Rao Int J Biological Med Res 2 (4), 1003-5 , 2011 2011 Citations: 16
Prevalence of self-medication practices among urban slum dwellers in Hyderabad, India S Katkuri, P Chauhan, K Shridevi, P Kokiwar, V Gaiki Int J Community Med Public Health 3 (7), 1816-9 , 2016 2016 Citations: 14
Prevalence of coronary risk factors in a rural community of Andhra Pradesh. PR Kokiwar, JG Rao, MD Shafee Indian Journal of Public Health 53 (1), 52-4 , 2009 2009 Citations: 12
Assessment of “depression, anxiety and stress” among students of schools at RHTC area catered by private medical college in South India VR, Zare., B, Ramesh., PR, Kokiwar. International Journal of Community Medicine and Public Health 5 (7), 3116-20 , 2018 2018 Citations: 11
A Cross‑Sectional Study on Correlates of High Blood Pressure among School‑Going Children in an Urban Area AV Katta, PR Kokiwar Indian Journal of Community Medicine 43 (2), 82-85 , 2018 2018 Citations: 9
Prevalence and purposes of gadget use among medical students VR Lunge, PR Kokiwar 2019 Citations: 8
A study to determine causes, prevalence and knowledge regarding consequences of substance abuse: a community based cross sectional study K Shridevi, S Gokuldas, K Prashant R International Journal of Community Medicine and Public health 3 (3), 730-34 , 2016 2016 Citations: 7
Clinical study of recurrent respiratory tract illness among pediatric patients KR Rao, SS Gandhi, PR Kokiwar Int J Contemp Pediatr 3 (1), 210-3 , 2016 2016 Citations: 7
Assessment of Diabetes Risk Using Indian Diabetes Risk Score Among Medical Students at a Medical College in Telangana, India PR Kokiwar Journal of Diabetology 12 (4), 542-5 , 2022 2022 Citations: 6