Personalized medicine and precision therapeutics Lakshmana Rao Atmakuri, Rajani Vetapalem, Ratna Kumari Yejerla, R. Radha, Udaya Guttikonda, Angilicam Avinash Innovations in Drug Discovery Exploring Cutting Edge Strategies and Technologies, 2025 Personalized medicine and precision therapeutics mean the shift from the mass provision of treatment to taking into account the peculiarities of an individual patient, including genetic background, environment, and behavior. It differs from the conventional treatment for everybody approach, but its virtue is the individualization of treatments for its best outcome and least side effects. Basic to precision medicine is the concept of biomarkers- measurable characteristics that are used to identify risk for illness, likely course, and therapeutic responsiveness. They are molecular markers discovered using high-end techniques such as genomics, proteomics and metabolomics that allow for molecular stratification of patients. Companion diagnostics, as used here, have the critical role of assisting in the determination of the right treatment options that would suit a given patient based on the biomarker profile mentioned above, hence the overall clinical outcomes in patient treatment. Biological mechanisms and precision medicine concepts are illustrated by the actual examples of case studies on precision therapeutics. Two of these are immunotherapy and targeted therapy, both of which demonstrate how precision medicine is changing treatment patterns across different diseases and creating new hope for many.
Biopharmaceutical and Pharmacodynamic Characteristics of Telmisartan Oral Disintegrating Films Rajesh Kaza, Sujatha Kumari M, Kishore Babu M, Avinash A, Nagaraju R International Journal of Pharmaceutical Sciences and Nanotechnology, 2019 
 This research work was aimed to develop the telmisartan fast dissolving films. Fast dissolving films allow rapid drug dissolution in the oral cavity and thereby bypass the first pass metabolism. Solid dispersions of telmisartan using natural polymers such as hupu gum (HG), guar gum (GG) and xanthan gum (XG) were prepared by kneading technique and the optimized solid dispersion was exploited in the development of rapidly dissolving film. Telmisartan films were prepared by solvent casting method using different grades of HPMC (E5, 50 cps and K4M). Six formulations (FT1-FT6) of telmisartan films were prepared and evaluated for their physical characteristics such as thickness, tensile strength, percentage elongation, weight variation, folding endurance, drug content uniformity and surface pH and gave satisfactory results. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. The formulations were subjected to disintegration, in vitro drug release and pharmacodynamic studies on spontaneous hypertensive rats (SHR). Amongst the formulations of FT1-FT6, FT6 was found as best formulation which contains HPMC E5 and telmisartan solid dispersion with guar gum at weight ratio of 1:2 and showed excellent film forming characteristics such as disintegration time at 42 sec and percentage drug release 97.98% within 10 minutes. The optimized film formulation (FT6) showed excellent stability over 45 days when stored at 40°C/60% RH. The pharmacodynamic study in SHR proved that fast dissolving films of telmisartan produced a faster onset of action.
Design and characterization of atenolol floating microcapsules International Journal of Pharmaceutical Research, 2016
Indole: The molecule of diverse pharmacological activities Journal of Chemical and Pharmaceutical Research, 2011
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Indole: The molecule of diverse pharmacological activities PRRVC ”. Ramesh Dhani, A. Avinash, S. K. Salenaagina, M. V. Saicharan Teja ... Journal of Chemical and Pharmaceutical Research 3 (5), 519-523 , 2011 2011 Citations: 49
kumar ND, Sreenivasulu M, Rao PS. Design and Evaluation of Famotidine Floating Tablets A Avinash, SS Swarupa, K Siva, D Sirisha, S Riyaz Int J Innov Pharmace Res 6 (1), 440-445 , 2015 2015 Citations: 11
Reactivity of novel substituted benzimidazole derivatives DLK Ramesh Dhani, Gopinath Chakka, M.V. Sai Charan Teja, P. Mastanaiah, A ... International Journal of Advances in Pharmacy and Nanotechnology 1 (3), 114-120 , 2011 2011 Citations: 4
A Review on Solubility Enhancement Using Hydrotropy Asian Journal of Medical and Pharmaceutical Sciences 4 (1), 33-38 , 2016 2016 Citations: 3
Formulation and Evaluation of Famotidine Buccal Tablets SRS Karimunnisa Shaik, Shanmugam V, Avinash Angilicam International Journal of Innovative Pharmaceutical Research 5 (2), 410-417 , 2014 2014 Citations: 3
Design, Characterization and Evaluation of Chrono-modulated Nateglinide using pulsatile Drug Delivery System DMS Angilicam Avinash, Avula Sushma, Koneti Lalasa, Siddabathina Prasanth ... World Journal of Pharmacy and Biotechnology 3 (1), 1-6 , 2016 2016 Citations: 2
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