Dr Absarul Haque

Scopus Publications

Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis
Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Tainus Ali, Sajjad Karim, Loubna Siraj Mira, Fahd Al‐Abbasi, Murad Aljiffry, Mohammed Ghunaim, Abdulrahman Sibiany, Peter Natesan Pushparaj
Health Science Reports, 2026
Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes. Methods Tumor tissues were obtained from 84 Saudi CRC patients, and their disease data and tumor characteristics were recorded. The MutS homolog 2 ( MSH2 ) gene was analyzed for molecular underlying pathogenic variants, and various bioinformatic approaches were utilized to predict the lethality of these variants and their association with cancer pathogenicity. Results A total of 17 variants in four CRC types were identified in 14 patients of whom two were novel missense variations, c.2312 C > G (p.Ala771Gly) and c.2390 T > G (p. Val797Gly). The p.Ala771Gly variant was detected in five individuals (5.95% allelic frequency), while the p.Val797Gly variant was found in three patients (3.57% allelic frequency). Further analysis using the Have (y)Our Protein Explained (HOPE) tool predicted that these variants may deleteriously affect MSH2 protein‐DNA and ATP binding, resulting in functional damage to MSH2, which impairs its functions and protein‐binding affinities. Conclusion This study provides new insights into the genetic basis of CRC and highlights the importance of molecular analysis for detecting novel variants. These novel mutations can be therapeutic targets for novel drugs in precision medicine.
Discovery and analysis of a novel mutation (G774E) in the Lysine Demethylase 6A (KDM6A) gene causing congenital heart disease with various neurodevelopmental disorders
Mahmood Rasool, Majed Alsulami, Ayat Mohammed Shorbaji, Absarul Haque, Loubna Siraj Mira, Mohammad Basabrain, Sherin Bakhashab, Mohamed Nabil Alama, Sajjad Karim, Isam M Abu Zeid, Hisham N Altayb, Peter Natesan Pushparaj
Advancements in Life Sciences, 2026
Background: Congenital heart defects (CHD) are the most common birth defects, affecting approximately 0.8% of live births worldwide. CHD impairs the function and structure of the heart and blood vessels. Due to this damage, blood flow is impaired, which affects many major organs, including the brain, and causes various neurodevelopmental disorders.Methods: In this study, we recruited a five-generation pedigree for analysis. The proband was born with congenital heart disease and subsequently developed various neurodevelopmental disorders. To understand the causes of the disease, we performed clinical whole-exome sequencing and applied various bioinformatics tools to determine the pathogenicity of the mutation.Results: Molecular investigation revealed a novel lethal mutation (c.2321G>A) in KDM6A, causing the substitution of Glycine to Glutamic acid (Gly774Glu). The mutation was further confirmed using Sanger sequencing. Various bioinformatics tools were used to predict the lethality of the mutations. KDM6A disruption causes various diseases, among which Kabuki syndrome is the most prevalent.Conclusion: Our findings may aid in the further development of genome-based medicines, leading to a reduction in mortality rates and improved healthcare in newborns.Keywords:Congenital heart disease, Kabuki syndrome, Neurodevelopmental disorder, Whole exome sequencing, Novel mutation
Phytochemical Profiling and Anticancer Potential of Fagonia cretica L. Extracts on Liver Cancer (HepG2) Cells using In vitro and In silico Approaches
Fatima Arshad, Awais Altaf, Ali Raza Arshad, Asia Kiran, Muhammad Sarwar, Sumaira Sharif, Tahir Maqbool, Turki S. Abujamel, Absarul Haque, Muhammad Imran Naseer
Anti Cancer Agents in Medicinal Chemistry, 2026
Background: Cancer is a complex multifactorialdisease charcterized by the progression of genetic and epigenetic changes in human cells . Plant-based derivatives with antioxidant and anticancer properties have been of great interest in treating several human ailments. Objective: This study investigates the in-vitro antioxidative, cytotoxic, and apoptotic activities of different Fagonia cretica L. (F. cretica) leaf extracts. Methods: In-vitro DPPH, nitric oxide, superoxide anion, and hydrogen peroxide assays were used to evaluate the antioxidative potential of ethanolic extract of F. cretica (EFC) and hexane extract of F. cretica (HFC). The antiproliferative potential was determined using MTT, crystal violet, and annexin V/PI staining protocols on liver cancer (HepG2) and noncancerous (HEK-293) cell lines. Through In silico analysis, bioactive drug-like phytocompounds identified by GC-MS were evaluated. Results: Higher concentrations of total flavonoid contents (TFCs), total phenolic contents (TPCs), and tannins with strong antioxidant potential were observed in EFC extract as compared to HFC extract. Furthermore, the EFC extract proved to be more cytotoxic with a selective index (SI) of 12.92 than HFC (SI; 5.46) towards experimental cell lines. Moreover, EFC extract showed 82.31% apoptotic induction on HepG2 cells compared to hexane extract and cisplatin (standard drug). From the GC-MS analysis of F. cretica, 32 bioactive compounds were identified from the EFC extract and 21 from the HFC extract. In silico study revealed that 5-(4,5-Dihydro-3Hpyrrol- 2-ylmethylene)-4,4-dimethylpyrrolidine-2-thione showed the highest docking score of -8.9 kcal/mol and - 8.6 kcal/mol against TNF-α and TGF-β, respectively. Conclusion: In conclusion, EFC extract and its bioactive compounds have a scientifically proven role in liver cancer management, but further research is required to validate their therapeutics through clinical trials.
The mutational spectrum of NRAS gene discovers a novel frameshift mutation (E49R) in Saudi colorectal cancer patients
Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Abdulrahman Sibiany, Mohammed Saad Alamri, Samer Mohammed Hassan Alqarni, Irfan A. Rather, Adeel G. Chaudhary, Sajjad Karim, Peter Natesan Pushparaj
Cancer Cell International, 2025
Colorectal cancer (CRC) is a major health problem the world face currently and one of the leading causes of death worldwide. CRC is genetically heterogeneous and multiple genetic aberrations may appear on course of the disease throughout patient's lifetime. Genetic biomarkers such as BRAF, KRAS, and NRAS may provide early precision treatment options that are crucial for patient survival and well-being. The aim of this study was to identify pathogenic mutations in the NRAS gene causing colorectal cancer in the Saudi population. We enrolled 80 CRC tumor tissue samples and performed molecular analyses to establish the mutation spectrum status in the western region of Saudi Arabia. We identified 5 different mutations in 10 patients, 4 of whom were reported previously (G10R, E37K, Q61K, and Q61*) in the literature while we discovered one novel lethal insertion mutation (E49R). A novel identified insertion mutation was present in the third codon of the NRAS gene [c.145 insA (p.Glu49ArgTer85)], causing a frameshift in the amino acid sequence of the protein, and leading to an aberrant and truncated protein of 85 amino acids. Subsequent bioinformatics analysis showed that the mutation was highly deleterious and affected protein function to a greater extent. This identification may further improve the prognosis of CRC and benefit subsequent treatment choices.
The roles of FGFR, EGFR and AMP-activated protein kinase pathway in colorectal cancer stem cells derived spheroids: Implications in colorectal cancer treatment
Asian Journal of Agriculture and Biology, 2025
Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer
Absarul Haque, Ghazanfar Ali Baig, Abdulelah Saleh Alshawli, Mohammed Alharthi, Muhammad Imran Naseer, Peter Natesan Pushparaj, Mahmood Rasool, F A Dain Md Opo
Journal of King Saud University Science, 2025
Colorectal cancer (CRC) is a significant cause of death globally, due to the emergence of multidrug resistance (MDR), which limits the effectiveness of conventional chemotherapy. Multidrug resistance-associated protein 2 (MRP2) plays a critical role in the drug resistance observed in cancer. MRP2 contributes to cross-resistance to several structurally and functionally diverse chemotherapeutic drugs. This study aims to evaluate potential anticancer agents and inhibitors of MRP2 to develop effective therapeutic strategies for MRP2-associated non-responsive CRC. In this study, molecular docking was performed to reveal the MRP2 binding sites and affinity with anticancer drugs. Interaction analysis of chemotherapeutic drugs with MRP2 demonstrated irinotecan>doxorubicin>capecitabine>trifluridine>oxaliplatin>gemcitabine>tipiracil>5-Fluorouracil (5-FU) to be the decreasing order of binding affinities. 5-FU exhibited the lowest binding affinity, while irinotecan displayed the highest. In contrast, docking analysis of inhibitors with MRP2 showed probencid<MK-571<S-(2,4-dinitrophenyl) glutathione<dihydromyricetin <zafirlukast< montelukast to be the order of increasing binding affinities. Montelukast showed the highest binding affinity with MRP2. Notably, our findings showed that irinotecan, oxaliplatin, montelukast, and zafirlukast bind specifically to MRP2 regions TM12 and TM15. Our results suggest that 5-FU could be a more effective option for MRP2-overexpressing CRC as it interacts poorly with MRP2. Additionally, gemcitabine and oxaliplatin shared common binding sites, implying that competitive binding may help overcome MDR. Furthermore, our findings imply that a combinatorial approach utilizing irinotecan/oxaliplatin and an inhibitor may offer an efficient approach to combat drug resistance in CRC, paving the way for improved patient outcomes.
The discovery and simulation analysis of a novel mutation c.40 G < T (V14F) in the NRAS gene in patients with colorectal cancer in Saudi Arabia
Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Abdulrahman Sibiany, Mohammed Saad Alamri, Samer Mohammed Hassan Alqarni, Irfan A. Rather, Adeel Gulzar Chaudhary, Peter Natesan Pushparaj, Sajjad Karim
Journal of King Saud University Science, 2024
Colorectal cancer (CRC) is the most diagnosed cancer in men and the second most common cancer in women and remains associated with high morbidity and mortality in Saudi Arabia. The current understanding of genetic heterogeneity of colorectal cancer biology encourages the identification of the genetic causes of CRC in the Saudi population. In this study, we ascertained 89 CRC patients’ tumor samples from Saudi Arabia and investigated the molecular alterations of the NRAS proto-oncogene, GTPase (NRAS) gene by sequencing the collected CRC tumor tissue samples to identify gene mutations. The impact of mutations was analyzed using different bioinformatics tools including Missense3D algorithm of Swiss Model platform, molecular dynamics simulations using YASARA DYNAMICS and Protein Variation Effect Analyzer (PROVEAN) tool. We identified a novel mutation c.40 G > T, in one patient in whom valine was replaced by phenylalanine (V14F). Notably, we also identified another mutation in the same codon c.40 G > A where valine is replaced by isoleucine (V14I). Our in-silico analysis revealed that this novel mutation alters the binding affinity of the NRAS gene substantially, and as a result, could have lethal consequences on the downstream signaling genes and pathways including MAPK and PI3K involved in regulating CRC growth and progression. These findings provide insights into the molecular etiology of CRC in general and particularly in the Saudi population. Thus, these findings in NRAS mutation testing may also guide further treatment modalities, and more personalized therapy may be optimized.
Deciphering gene expression signatures in liver metastasized colorectal cancer in stage IV colorectal cancer patients
Mahmood Rasool, Sajjad Karim, Absarul Haque, Mohammed Alharthi, Adeel G Chaudhary, Peter Natesan Pushparaj
Journal of King Saud University Science, 2024
Colorectal cancer (CRC) liver metastasis (CRLM) is a clinical challenge, and optimizing treatment strategies is crucial for improving patient outcomes. This study aimed to identify gene expression signatures associated with CRLM for early diagnosis and improved treatment outcomes. We obtained RNA-seq data of 34 samples (17 colorectal tumor samples from metastasized liver and 17 samples from normal surrounding colonic epithelia) from the Gene Expression Omnibus (GEO) with accession number GSE50760 and analysed them using next-generation knowledge discovery (NGKD) tools such as GEO2R and web based gene set enrichment analysis (WebGestalt). A total of 18808 genes were identified in the initial analysis which were further reduced to 2490 differentially expressed genes (DEGs) after applying different parameters using GEO2R tools. Furthermore, in the gene set enrichment analysis (GSEA), we analysed the biological processes, cellular components, and molecular functions. We analysed four pathways: KEGG, panther, reactome, and wikipathway cancer. In each analysis, we ascertained the most important top expressed and downregulated genes. We identified various gene sets that could be used as important prognostic and therapeutic markers, particularly in patients with advanced CRLM. Future studies in larger cohorts may further our research findings to establish the best prognostic biomarkers for early diagnosis and overall survival.
Discovery of a novel mutation F184S (c.551T>C) in GATA4 gene causing congenital heart disease in a consanguineous Saudi family
Mahmood Rasool, Peter Natesan Pushparaj, Absarul Haque, Ayat Mohammed Shorbaji, Loubna Siraj Mira, Sherin Bakhashab, Mohamed Nabil Alama, Muhammad Farooq, Sajjad Karim, Lars Allan Larsen
Heliyon, 2024
Background & aim: Congenital heart disease (CHD) is the most common cause of non-infectious deaths in infants worldwide. However, the molecular mechanisms underlying CHD remain unclear. Approximately 30 % of the causes are believed to be genetic mutations and chromosomal abnormalities. In this study, we aimed to identify the genetic causes of CHD in consanguineous families. Methods: An in-silico homology model was created using the Alphafold homology model structure of GATA4 (AF-P43694-F1). The missense3D online program was used to evaluate the structural alterations. Results: . GATA4 is a highly conserved zinc-finger transcription factor, and its continuous expression is essential for cardiogenesis during embryogenesis. The in-silico model suggested a compromised binding efficiency with other proteins. Several variant interpretation algorithms indicated that the F184S missense variant in GATA4 is damaging, whereas HOPE analysis indicated the functional impairment of DNA binding of transcription factors and zinc-ion binding activities of GATA4. Conclusion: appears to cause recessive CHD in the family. In silico analysis suggested that this variant was damaging and caused multiple structural and functional aberrations. This study may support prenatal screening of the fetus in this family to prevent diseases in new generations.
Whole exome sequencing of a novel homozygous missense variant in PALB2 gene leading to Fanconi anaemia complementation group
Angham Abdulrhman Abdulkareem, Bader Shirah, Hala Bagabir, Absarul Haque, Muhammad Naseer
Biomedical Reports, 2024
Partner and localiser of BRCA2 (PALB2), also known as FANCN, is a key tumour suppressor gene in maintaining genome integrity. Monoallelic mutations of PALB2 are associated with breast and overian cancers, while bi-allelic mutations cause Fanconi anaemia (FA). In the present study, whole exome sequencing (WES) identified a novel homozygous missense variant, NM_024675.3: c.3296C>G (p.Thr1099Arg) in PALB2 gene (OMIM: 610355) that caused FA with mild pulmonary valve stenosis and dysmorphic and atypical features, including lymphangiectasia, non-immune hydrops fetalis and right-sided pleural effusion in a preterm female baby. WES results were further validated by Sanger sequencing. WES improves the screening and detection of novel and causative genetic variants to improve management of disease. To the best of our knowledge, the present study is the first reported FA case in a Saudi family with phenotypic atypical FA features. The results support the role of PALB2 gene and pathogenic variants that may cause clinical presentation of FA. Furthermore, the present results may establish a disease database, providing a groundwork for understanding the key genomic regions to control diseases resulting from consanguinity.
A missense variant in the PACS2 gene cause Epileptic Encephalopathy and seizures in Saudi family
Muhammad Imran Naseer, Absarul Haq
Pakistan Journal of Medical Sciences, 2024
Evaluating the Therapeutic Efficacy of Swertia Chirayita in Liver Cancer Management
Fatima Arshad, Awais Altaf, Madeeha Shahzad Lodhi, Arif Malik, Huma Sattar, et al.
Journal of Biological Regulators and Homeostatic Agents, 2024
Enhancing MS-275 Anticancer Activity: Encapsulation of MS-275 in TPGS Micelles Demonstrated High Efficiency
Abdulelah S. Alshawli, Tarek A. Ahmed, Farid Ahmed, Absarul Haque, Khalid M. El-Say, Abdelsattar M. Omar, Muhammad Abu-Elmagd
Journal of Nanotechnology, 2024
The differential regulation of tumor suppressor genes (SAMD9, SPRED1, TGFBI, DUSP6, CDX2, TP53) and MAPK/ERK signaling pathway in colorectal cancer
Asian Journal of Agriculture and Biology, 2024
Identification of Natural Compounds as CTX-M-15 Inhibitors for the Management of Multidrug-Resistant Bacteria: An in-silico study
Advancements in Life Sciences, 2023
A Novel Homozygous Nonsense Variant in the DYM Underlies Dyggve-Melchior-Clausen Syndrome in Large Consanguineous Family
Abu Bakar, Sulaiman Shams, Nousheen Bibi, Asmat Ullah, Wasim Ahmad, Musharraf Jelani, Osama Yousef Muthaffar, Angham Abdulrhman Abdulkareem, Turki S. Abujamel, Absarul Haque, Muhammad Imran Naseer, Bushra Khan
Genes, 2023
A Systems Biology and LASSO-Based Approach to Decipher the Transcriptome–Interactome Signature for Predicting Non-Small Cell Lung Cancer
Firoz Ahmed, Abdul Arif Khan, Hifzur Rahman Ansari, Absarul Haque
Biology, 2022
The Relationship between Psychological Disability and Religious Practice and Coping Strategies in Caregivers of Children with Traumatic Brain Injury in Pakistani Population
Ayesha, Saboor Ahmad, Shazadi Saba, Muhammad Kashif, Danish Ali Khan, Absarul Haque, Muhammad Imran Naseer, Adel M Abuzenadah, Anwar M. Hashem, Shafiq Ur Rehman
Healthcare Switzerland, 2022
Retraction Note to: Epidemiology and molecular typing of Candida isolates from burn patients
Nivedita Gupta, Absarul Haque, Ali Abdul Lattif, R. P. Narayan, Gauranga Mukhopadhyay, Rajendra Prasad
Mycopathologia, 2022
COVID-19 Vaccination Drive in a Low-Volume Primary Care Clinic: Challenges & Lessons Learned in Using Homegrown Self-Scheduling Web-Based Mobile Platforms
Reita N. Agarwal, Rajesh Aggarwal, Pridhviraj Nandarapu, Hersheth Aggarwal, Ashmit Verma, Absarul Haque, Manish K. Tripathi
Vaccines, 2022
Interaction Analysis of MRP1 with Anticancer Drugs Used in Ovarian Cancer: In Silico Approach
Absarul Haque, Ghazanfar Ali Baig, Abdulelah Saleh Alshawli, Khalid Hussain Wali Sait, Bilal Bin Hafeez, Manish Kumar Tripathi, Badrah Saeed Alghamdi, Hani S. H. Mohammed Ali, Mahmood Rasool
Life, 2022
Survival and prognostic factors in women treated for epithelial ovarian cancer in western region of Saudi Arabia
Khalid H. Sait, Mohammad Z. Alam, Absarul Haque, Hesham K. Sait, Maram K. Sait, Nisreen M. Anfinan
Saudi Medical Journal, 2022
Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients
Mahmood Rasool, Angel Carracedo, Abdulrahman Sibiany, Faten Al-Sayes, Sajjad Karim, Absarul Haque, Peter Natesan Pushparaj, Muhammad Asif, Niaz M. Achakzai
Bioengineered, 2021
Assessment of clinical variables as predictive markers in the development and progression of colorectal cancer
Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul Ain, Rabia Rasool, Muhammad Asif, Nisreen Anfinan, Absarul Haque, Hina Alam, Sagheer Ahmed, Mohammad Hamid Hamdard
Bioengineered, 2021
MDR1 Gene Polymorphisms and Its Association With Expression as a Clinical Relevance in Terms of Response to Chemotherapy and Prognosis in Ovarian Cancer
Absarul Haque, Khalid Hussain Wali Sait, Qamre Alam, Mohammad Zubair Alam, Nisreen Anfinan, Abdul Wahab Noor Wali, Mahmood Rasool
Frontiers in Genetics, 2020
Genetic investigations on causes of male infertility in Western Saudi Arabia
Mohd A. Beg, Eberhard Nieschlag, Taha A. Abdel‐Meguid, Qamre Alam, Ahmed Abdelsalam, Absarul Haque, Hisham A. Mosli, Osama S. Bajouh, Adel M. Abuzenadah, Mohammed Al‐Qahtani
Andrologia, 2019
Implications of advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs) and other biomarkers in the development of cardiovascular diseases
Mahmood Rasool, Arif Malik, Tariq Tahir Butt, Muhammad Abdul Basit Ashraf, Rabia Rasool, Ayesha Zahid, Sulayman Waquar, Muhammad Asif, Ahmad Zaheer, Abdul Jabbar, Maryam Zain, Asim Mehmood, Tahira Batool Qaisrani, Imran Riaz Malik, Sami Ullah Khan, Zeenat Mirza, Absarul Haque, Mohammed Hussein Al-Qahtani, Sajjad Karim
Saudi Journal of Biological Sciences, 2019
Current progress on peroxisome proliferator-activated receptor gamma agonist as an emerging therapeutic approach for the treatment of alzheimer’s disease: An update
Mahmood Ahmad Khan, Qamre Alam, Absarul Haque, Mohammad Ashafaq, Mohd Jahir Khan, Ghulam Md Ashraf, Mahboob Ahmad
Current Neuropharmacology, 2019
Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders
Mahmood Rasool, Arif Malik, Muhammad Abdul Basit Ashraf, Mahwish Arooj, Asia Kiran, Sulayman Waquar, Ujala Ayyaz, Ayesha Zahid, Ahmad Zaheer, Abdul Jabbar, Maryam Zain, Amir Raza, Asim Mehmood, Tahira Batool Qaisrani, Zeenat Mirza, Mohammed Hussein Al-Qahtani, Sajjad Karim, Absarul Haque
Saudi Journal of Biological Sciences, 2018
Optimization of antibacterial activity of ethanolic extracts of Eucalyptus tereticornis and Nigella sativa: Response surface methodology
Pakistan Journal of Pharmaceutical Sciences, 2018
Assessment of IL-18 Serum Level and Its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients
Nasimudeen R. Jabir, Chelapram K. Firoz, Mohammad A. Kamal, Ghazi A. Damanhouri, Mohammed Nabil Alama, Qamre Alam, Absarul Haque, Hussein A. Almehdar, Shams Tabrez
Journal of Cellular Biochemistry, 2017
Infectious agents and neurodegenerative diseases: Exploring the links
Mohammad Alam, Qamre Alam, Mohammad Kamal, Asif Jiman-Fatani, Esam Azhar, Mohammad Khan, Absarul Haque
Current Topics in Medicinal Chemistry, 2017
A surveillance study on the prevalence and antimicrobial resistance pattern among different groups of bacteria isolated from Western province of Saudi Arabia
Biomedical Research India, 2017
Translational shift of HSP90 as a novel therapeutic target from cancer to neurodegenerative disorders: An emerging trend in the cure of Alzheimer's and Parkinson's diseases
Qamre Alam, Mohammad Zubair Alam, Khalid Hussain Wali Sait, Nisreen Anfinan, Abdul Wahab Noorwali, Mohammad Amjad Kamal, Mohd Sajjad Ahmad Khan, Absarul Haque
Current Drug Metabolism, 2017
Evaluation of antimicrobial activity of ethanolic extracts of azadirachta indica and psidium guajava against clinically important bacteria at varying ph and temperature
Biomedical Research India, 2017
DARPins bioengineering and its theranostic approaches: Emerging trends in protein engineering
Mahmood Rasool, Arif Malik, Mubashir Hussain, Kalsoom A. Haq, Kiran Butt, Muhammad Abdul Basit Ashraf, Muhammad Imran Naseer, Muhammad Asif, Rozena Shaikh, Mohammad Zahid Mustafa, Qamre Alam, Ghulam Rasool, Waseem Ahmad, Absarul Haque, Mohammad Amjad Kamal
Current Pharmaceutical Design, 2017
Effect of iron overload on renal functions and oxidative stress in beta thalassemia patients
Mahmood Rasool, Arif Malik, Uzma Jabbar, Irshad Begum, Mahmood H. Qazi, Muhammad Asif, Muhammad I. Naseer, Shakeel A. Ansari, Jummanah Jarullah, Absarul Haque, Mohammad S. Jamal
Saudi Medical Journal, 2016
Identification and Antifungal susceptibility testing of Candida species: A Comparison of Vitek-2 system with conventional and molecular methods
Ravinder Kaur, MeghSingh Dhakad, Ritu Goyal, Absarul Haque, Gauranga Mukhopadhyay
Journal of Global Infectious Diseases, 2016
Current understanding of HSP90 as a novel therapeutic target: An emerging approach for the treatment of Cancer
Absarul Haque, Qamre Alam, Mohammad Zubair Alam, Esam I. Azhar, Khalid Hussain Wali Sait, Nisrin Anfinan, Gohar Mushtaq, Mohammad Amjad Kamal, Mahmood Rasool
Current Pharmaceutical Design, 2016
Inflammatory process in Alzheimer’s and Parkinson’s diseases: Central role of cytokines
Qamre Alam, Mohammad Zubair Alam, Gohar Mushtaq, Ghazi A. Damanhouri, Mahmood Rasool, Mohammad Amjad Kamal, Absarul Haque
Current Pharmaceutical Design, 2016
BAD, a proapoptotic protein, escapes ERK/RSK phosphorylation in deguelin and siRNA-treated hela cells
Samra Hafeez, Mahwish Urooj, Shamiala Saleem, Zeeshan Gillani, Sumaira Shaheen, Mahmood Husain Qazi, Muhammad Imran Naseer, Zafar Iqbal, Shakeel Ahmed Ansari, Absarul Haque, Muhammad Asif, Manzoor Ahmad Mir, Ashraf Ali, Peter Natesan Pushparaj, Mohammad Sarwar Jamal, Mahmood Rasool
Plos One, 2016
Allelic variance among ABO blood group genotypes in a population from the western region of Saudi Arabia
Abdularahman B.O. Mohamed, Salwa Ibrahim Hindawi, Sameer Al-harthi, Qamre Alam, Mohammad Zubair Alam, Absarul Haque, Waseem Ahmad, Ghazi A Damanhouri
Blood Research, 2016
Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism
Safder S. Ganaie, Absarul Haque, Erdong Cheng, Tania S. Bonny, Nilshad N. Salim, Mohammad A. Mir
Biochemical Journal, 2014
Microbial sorption and desorption of chromium, cadmium and nickel from aqueous solution by dried and non growing biomasses of Staphylococcus gallinarum W-61
Journal of Pure and Applied Microbiology, 2014
A possible link of gut microbiota alteration in type 2 diabetes and Alzheimer's disease pathogenicity: An update
Mohammad Alam, Qamre Alam, Mohammad Kamal, Adel Abuzenadah, Absarul Haque
CNS and Neurological Disorders Drug Targets, 2014
Genomic linkage between alzheimer's disease and type 2 diabetes
Taoufik Nedjadi, Absarul Haque, Qamre Alam, Siew Gan, Adeel Chaudhary, Adel Abuzenadah, Ghazi Damanhouri, Mohammad Kamal
CNS and Neurological Disorders Drug Targets, 2014
Effect of electromagnetic radiations on neurodegenerative diseases-technological revolution as a curse in disguise
Gulam Hasan, Ishfaq Sheikh, Sajjad Karim, Absarul Haque, Mohammad Kamal, Adeel Chaudhary, Essam Azhar, Zeenat Mirza
CNS and Neurological Disorders Drug Targets, 2014
Candida identification: A journey from conventional to molecular methods in medical mycology
Mohammad Zubair Alam, Qamre Alam, Asif Jiman-Fatani, Mohammad Amjad Kamal, Adel M. Abuzenadah, Adeel G. Chaudhary, Mohammad Akram, Absarul Haque
World Journal of Microbiology and Biotechnology, 2014
A nanotechnological approach to the management of Alzheimer disease and type 2 diabetes
Qamre Alam, Mohammad ZubairAlam, Sajjad Karim, Siew Gan, Mohammad Kamal, Asif Jiman-Fatani, Ghazi Damanhouri, Adel Abuzenadah, Adeel Chaudhary, Absarul Haque
CNS and Neurological Disorders Drug Targets, 2014
Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells
Islam T. M. Hussein, Erdong Cheng, Safder S. Ganaie, Michael J. Werle, Sheema Sheema, Absarul Haque, Muhammad A. Mir
Journal of Virology, 2012
Characterization of the interaction between hantavirus nucleocapsid protein (N) and ribosomal protein S19 (RPS19)
Erdong Cheng, Absarul Haque, Mary Ashley Rimmer, Islam T.M. Hussein, Sheema Sheema, Alex Little, Mohammad A. Mir
Journal of Biological Chemistry, 2011
Recent Advances in Hantavirus Molecular Biology and Disease
Islam T.M. Hussein, Abdul Haseeb, Absarul Haque, Mohammad A. Mir
Advances in Applied Microbiology, 2011
Interaction of hantavirus nucleocapsid protein with ribosomal protein s19
Absarul Haque, Mohammad A. Mir
Journal of Virology, 2010
Hantavirus nucleocapsid protein has distinct m7G cap- and RNA-binding sites
Mohammad A. Mir, Sheema Sheema, Abdul Haseeb, Absarul Haque
Journal of Biological Chemistry, 2010
Allelic variants of ABC drug transporter Cdr1p in clinical isolates of Candida albicans
Absarul Haque, Versha Rai, Birendra Singh Bahal, Shipra Shukla, Ali Abdul Lattif, Gauranga Mukhopadhyay, Rajendra Prasad
Biochemical and Biophysical Research Communications, 2007
Interactions between bacteria and Candida in the burn wound
Nivedita Gupta, Absarul Haque, Gauranga Mukhopadhyay, R.P. Narayan, Rajendra Prasad
Burns, 2005
Susceptibility Pattern and Molecular Type of Species-Specific Candida in Oropharyngeal Lesions of Indian Human Immunodeficiency Virus-Positive Patients
Ali Abdul Lattif, Uma Banerjee, Rajendra Prasad, Ashutosh Biswas, Naveet Wig, Neeraj Sharma, Absarul Haque, Nivedita Gupta, Najma Z. Baquer, Gauranga Mukhopadhyay
Journal of Clinical Microbiology, 2004
Epidemiology and molecular typing of Candida isolates from burn patients
Nivedita Gupta, Absarul Haque, Ali Abdul Lattif, R. P. Narayan, Gauranga Mukhopadhyay, Rajendra Prasad
Mycopathologia, 2004

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