Hassan Valadbeigi

@isid.research.ac.ir

Ilam University of Medical Sciences, Ilam,
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran

Hassan Valadbeigi


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RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology, Applied Microbiology and Biotechnology
28

Scopus Publications

526

Scholar Citations

12

Scholar h-index

13

Scholar i10-index

Scopus Publications

  • Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions
    Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi
    Pharmacology Research and Perspectives, 2026
    The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and gut microbiota dysregulation. Metformin, a first‐line antidiabetic agent, exhibits pleiotropic pharmacological properties beyond its glucose‐lowering effects, such as anti‐inflammatory, antiproliferative, and microbiota‐modulating activities. These multifaceted mechanisms position metformin as a promising therapeutic candidate for a spectrum of disorders, from IBS to liver disorders. This review synthesizes preclinical and clinical evidence supporting the therapeutic potential of metformin across GI pathologies—such as Helicobacter pylori infection, inflammatory bowel disease, colorectal cancer, and hepatocellular carcinoma—while elucidating its molecular mechanisms, such as AMPK/mTOR modulation, NF‐κB inhibition, and gut barrier stabilization. We critically evaluate combination therapies, ongoing clinical trials, and challenges, including lactic acidosis risk and GI intolerance to position metformin as a repurposed agent for GI disease management.
  • Molecular Characterizations of Carbapenem Resistance and Colistin Heteroresistance in Multidrug-Resistant Acinetobacter baumannii
    Nazanin Omidi, Ebrahim Kouhsari, Behrooz Sadeghi Kalani, Vahab Hassan Kaviar, Saeed Khoshnood, Hassan Valadbeigi, Mohammad Hossein Haddadi, Farzaneh Khodaei, Abbas Maleki
    Current Microbiology, 2026
  • Injectable hydrogel and its potential therapy for peri-implantitis
    Fahimeh Feili, Hassan Valadbeigi, Babak Negahdari, Saeed Khooshnod, Abbas Maleki, Mohammad Hossein Haddadi
    International Journal of Polymeric Materials and Polymeric Biomaterials, 2026
    Peri-implantitis is a destructive inflammatory condition around dental implants, crucial in implantology due to its impact on implant failure, with prevalence ranging from 10 to 20% of implants. Injectable hydrogel has gained attention as a promising biomaterial for the prevention and treatment of peri-implantitis, offering a minimally invasive approach to infection control, inflammation modulation, and tissue regeneration. The use of bioactive agents such as antibiotics, growth factors, stem cells, and nanoparticles is noted for improving treatment effectiveness and inducing osteogenesis. Injectable hydrogels facilitate localized drug release, improve cell adhesion and proliferation, and support bone tissue regeneration, making them ideal candidates for peri-implantitis management. This review provides a detailed exploration of the physicochemical properties, cross-linking mechanisms, and responsiveness of injectable hydrogels to external stimuli, such as pH, temperature, and ionic strength. The goal of this review is to summaries the key components that are required for creating effective peri-implantitis targeting injectable hydrogels. The potential of injectable hydrogels for managing peri-implantitis by combating infection, inflammation, and tissue regeneration was especially discussed, as well as the challenges for constructing effective hydrogel, will be discussed. This work integrates material science with clinical dentistry for the first time to address peri-implantitis, providing actionable data for polymer chemists and clinicians by reviewing the latest advances in hydrogels, particularly injectable ones, for treating this common dental condition, while identifying gaps and proposing solutions for its prevention and treatment.
  • Systematic review and meta-analysis of colistin heteroresistance in Klebsiella pneumoniae isolates
    Saeed Khoshnood, Mohammad Hossein Haddadi, Nourkhoda Sadeghifard, Abbas Maleki, Ebrahim Kouhsari, Hassan Valadbeigi
    BMC Infectious Diseases, 2025
    BACKGROUND: Antibiotic heteroresistance is a common phenotype observed in a variety of pathogenic bacteria such as K. pneumonia: A subpopulation of cells with a higher MIC than the dominant population is defined as heteroresistance. Several studies have demonstrated colistin heteroresistance in K. pneumonia leading to treatment failures. Therefore, we performed a systematic meta-analysis to summarize the current evidence on the prevalence of colistin heteroresistance in K. pneumonia isolates. METHODS: Multiple databases were searched to find relevant literature from 2008 to 2024, including PubMed, Scopus, Embase, and Web of Science. RESULTS: The meta-analysis included eighteen articles. According to the random effects model, the pooled proportion of heteroresistant K. pneumoniae was 0.315 (95% CI: 0.179-0.492). The heterogeneity was substantial, with Q [17] = 335.020, I² = 94.93%, and p < 0.001, suggesting that heteroresistance rates varied widely across the 18 included studies. CONCLUSION: In conclusion, our findings revealed that a prevalence of colistin heteroresistant detected in approximately 31.5%, of K. pneumonia. These findings are obtained and highlighted in this meta-analysis as a new guidance document for diagnosing and treating K. pneumonia infections is needed to raise the awareness of infectious disease specialists, gastroenterologists, and microbiologists to the heteroresistance to colistin in patients with a K. pneumonia infection.
  • Advances in aptamer technology and its updated applications in gastric cancer
    Sayedeh Azimeh Hosseini, Arghavan Rakhshani Nejad, Hassan Valadbeigi, Mohammad Hossein Haddadi, Monireh Bazdar
    Analytical Biochemistry, 2025
  • Assessment of Hypervirulent Klebsiella pneumoniae Isolates Using Multilocus Sequence Typing in West of Iran
    Mohammad Hossein Haddadi, Nourkhoda Sadeghifard, Saeed Khoshnood, Abbas Maleki, Sobhan Ghafourian, Hassan Valadbeigi
    Microbiologyopen, 2025
    BackgroundHypervirulent Klebsiella pneumonia (hvKP) has been considered due to severe infections such as pyogenic liver abscess, pneumonia, meningitis, endophthalmitis and necrotizing fasciitis. Due to the importance of the subject, hvKP isolates were investigated in the current study.MethodsA total of 52 non‐repetitive Klebsiella pneumonia (K. pneumonia) isolates were collected from clinical specimens (pleural fluid, blood, urine and trachal aspiration) of hospitalized patients in three well‐known hospitals in Ilam, west of Iran. Phenotypic tests, including the string test and potassium tellurite resistance, and molecular methods such as polymerase chain reaction (PCR) for iucA, iroB, iutA, and rmpA genes were used for hvKP diagnosis. In addition, multilocus sequence typing (MLST) was used to clarify the genetic relationships between isolates.ResultsThe mrkD, iroB, iucA, iutA, and rmpA genes were present in 6 (11.53%), 4 (7.7%), 12 (23.1%), 5 (9.6%), and 8 (15.4%) of the K. pneumoniae isolates, respectively. Eight isolates from different sources were identified with new sequence types (STs). These newly identified STs include ST‐7466, ST‐7467, ST‐7468, ST‐7469, ST‐7470, ST‐7471, ST‐7472 and ST‐7473.ConclusionsWe reported the eight new STs based on the MLST method for the phylogenetics of hvKP isolates. Our data indicated that no correlation between the phylogenetics of hvKP isolates. So, more extensive studies are needed to better understand the epidemiology of hvKP.
  • Identification of Antimicrobial Resistance Patterns, Type VI Secretion System, and Virulence Factors in Clinical Isolates of Klebsiella pneumoniae: A Cross-Sectional Study
    Mohammad Hossein Haddadi, Elahe Taki, Abbas Maleki, Jamshid Mashhadi, Fatemeh Shahi, Maryam Koupaei, Nourkhoda Sadeghifard, Reza Faraji, Melika Moradi, Hassan Valadbeigi, Saeed Khoshnood
    International Journal of Microbiology, 2025
    Background:Klebsiella pneumoniae is an opportunistic pathogen linked to a range of severe infections. It is classified into classic K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp) forms, with hvKp showing enhanced virulence. This study examines Type VI secretion system (T6SS) presence and virulence factors in cKp and hvKp strains while assessing antimicrobial resistance.Methods: Eighty‐three K. pneumoniae isolates were collected from hospitalized patients in Ilam, Iran, between June and December 2023. Antimicrobial susceptibility testing was conducted using the disk diffusion method. Hypervirulent K. pneumoniae isolates were identified by string test, tellurite resistance, and presence of peg-344, iucA, and iutA using polymerase chain reaction (PCR). Furthermore, PCR detected virulence, β‐lactamases, and T6SS genes.Results: Of 83 isolates, 16.87% and 83.13% were hvKp and cKp, respectively. All isolates were multidrug‐resistant (MDR), with 18.07% exhibiting carbapenem resistance. The pattern of antibiotic resistance in hvKp and cKp is not significantly different, except for ciprofloxacin, tetracycline, and azithromycin. Also, there was no significant difference between T6SS‐positive and T6SS‐negative isolates except for ciprofloxacin. T6SS presence did not significantly correlate with virulence or resistance genes, except for ciprofloxacin resistance (p = 0.0219).Conclusion: Surveillance, infection control, and targeted therapies are essential to combat hypervirulent and drug‐resistant K. pneumoniae.
  • Mixed oral biofilms are controlled by the interspecies interactions of Fusobacterium nucleatum
    Hassan Valadbeigi, Saeed Khoshnood, Babak Negahdari, Abbas Maleki, Medya Mohammadinejat, Mohammad Hossein Haddadi
    Oral Diseases, 2024
    BackgroundFusobacterium nucleatum (F. nucleatum) is an integral component of supra‐ and subgingival biofilms, especially more prevalent in subgingival areas during both periodontal health and disease.AimsIn this review, we explore the physical, metabolic, and genetic interactions that influence the role of F. nucleatum in the formation of mixed oral biofilms. The role of F. nucleatum in antibiotic resistance in oral biofilms was discussed and some therapeutic strategies were proposed.MethodsPubMed, Scopus, Google Scholar, and the Web of Science were extensively searched for English‐language reports.ResultsF. nucleatum‐derived proteins such as RadD, Fap2, FomA, and CmpA are involved in direct interactions contributing to biofilm formation, while autoinducer‐2 and putrescine are involved in metabolic interactions. Both groups are essential for the formation and persistence of oral biofilms. This study highlights the clinical relevance of targeted interactions of F. nucleatum in supra‐ and subgingival oral biofilms.ConclusionsBy focusing on these interactions, researchers and clinicians can develop more effective strategies to prevent biofilm‐related disease and reduce the spread of antibiotic resistance. Further research in this area is warranted to explore the potential therapeutic interventions that can be derived from understanding the interactions of F. nucleatum in oral biofilm dynamics.
  • Effect of ZnO nanoparticles on biofilm formation and gene expression of the toxin-antitoxin system in clinical isolates of Pseudomonas aeruginosa
    Hassan Valadbeigi, Nourkhoda Sadeghifard, Vahab Hassan Kaviar, Mohammad Hossein Haddadi, Sobhan Ghafourian, Abbas Maleki
    Annals of Clinical Microbiology and Antimicrobials, 2023
    Background Biofilm formation by Pseudomonas aeruginosa (P. aeruginosa) is known to be characteristic of this organism. This bacterium is considered one of the most life-threatening bacteria and has been identified as a priority pathogen for research by WHO. Biofilm-producing P. aeruginosa is a concern in many parts of the world due to antibiotic resistance. Alginate also plays an important role in the biofilm formation of P. aeruginosa as well as the emergence of antibiotic resistance in biofilms. In addition, the systems of toxin-antitoxin( TA) play an important role in biofilm formation. Metal nanoparticle(NP) such as zinc oxide (ZnO) also have extensive biological properties, especially anti-biofilm properties. Therefore, this study was conducted in relation to the importance of zinc oxide nanoparticles (ZnO NPs) in biofilm formation and also the correlation of gene expression of TA systems in clinical isolates of P. aeruginosa. Methods A total of 52 P. aeruginosa isolates were collected from burns (n = 15), UTI (n = 31), and trachea (n = 6) in hospitals in Ilam between May 2020 and October 2020. Biofilm formation was assessed using a microtiter plate assay. MIC and sub-MIC concentrations of ZnO NPs (10–30 nm with purity greater than 99.8%) in P. aeruginosa were determined. Subsequently, biofilm formation was investigated using sub-MIC concentrations of ZnO NPs. Finally, total RNA was extracted and RT- qPCR was used to determine the expression levels of genes of mazEF, mqsRA, and higBA of TA systems. Results Six isolates of P. aeruginosa were found to form strong biofilms. The results showed that ZnO NPs were able to inhibit biofilm formation. In our experiments, we found that the sub-MIC concentration of ZnO NPs increased the gene expression of antitoxins mazE and mqsA and toxin higB of TA systems treated with ZnO NPs. Conclusions In the present study, ZnO NPs were shown to effectively inhibit biofilm formation in P. aeruginosa. Our results support the relationship between TA systems and ZnO NPs in biofilm formation in P. aeruginosa. Importantly, the expression of antitoxins mazE and mqsA was high after treatment with ZnO NPs, but not that of antitoxin higA.
  • Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model
    Hassan Valadbeigi, Saeed Khoshnood, Babak Negahdari, Mohd Azmuddin Abdullah, Mohammad Hossein Haddadi
    Biomed Research International, 2023
    Introduction. Helicobacter pylori (H. pylori) induces gastritis by stimulating Th17 cells and related cytokines. The aim of our study was to investigate the synergistic effect of metformin with amoxicillin as an antibiotic in inhibiting H. pylori and modulating the immune response in a rat model. Methods. Forty-five male Sprague-Dawley rats were divided into seven groups and infected with H. pylori. Over the course of 14 days, all animals were treated with metformin and amoxicillin alone and in combination. The antibacterial activity of metformin was evaluated by growth curves and colony counts. The immunoregulatory effect on Treg/Th17 balance was assessed by flow cytometry, and the cytokine profile of IL-17A, IL-1β, IL-6, IL-8, TGF-β, and IL-10 was determined by ELISA. The effect of metformin on gene expression of cagA and IL-8 was investigated by RT-PCR. Pathological changes were assessed by hematoxylin and eosin (H&amp;E) staining and immunohistochemical (IHC) staining. Results. Metformin showed weak antibacterial activity against clinically isolated H. pylori. However, the combination of metformin and amoxicillin (AMX) showed strong synergistic antibacterial activity (ΣFIC=0.24). Compared with AMX, metformin reduced inflammation and tissue damage but resulted in increased bacterial growth. During metformin administration, both TGF-β levels and Treg cells increased dramatically (P=0.002). In synergy with AMX, metformin decreased the effective dose of antibiotic to eradicate H. pylori. Conclusions. The combination of metformin with potential antibiotics such as AMX had a positive effect on the relief of H. pylori-related inflammation by inducing Treg cells while successfully eliminating H. pylori.
  • Heteroresistance to clarithromycin and metronidazole in patients with a Helicobacter pylori infection: a systematic review and meta-analysis
    Ebrahim Kouhsari, Nourkhoda Sadeghifard, Arezoo Khadiv, Hojjat Sayadi, Taghi Amiriani, Sobhan Ghafourian, Hassan Valadbeigi, Marcela Krutova
    Annals of Clinical Microbiology and Antimicrobials, 2022
  • Molecular typing and antibiotic resistance patterns among clinical isolates of Acinetobacter baumannii recovered from burn patients in Tehran, Iran
    Abbas Maleki, Vahab Hassan Kaviar, Maryam Koupaei, Mohammad Hossein Haddadi, Behrooz Sadeghi Kalani, Hassan Valadbeigi, Somayeh Karamolahi, Nazanin Omidi, Marziyeh Hashemian, Nourkhoda Sadeghifard, Jasem Mohamadi, Mohsen Heidary, Saeed Khoshnood
    Frontiers in Microbiology, 2022
  • The prevalence of shiga toxin-1 in non-shigella dysenteriae isolates collected from diarrhea samples in patients, ahvaz, iran
    Nahid Mahdian, Ebrahim Kouhsari, Ali Gheysarzadeh, Abbas Maleki, Hassan Valadbeigi, Nourkhoda Sadeghifard
    Infectious Disorders Drug Targets, 2021
  • Comparison of toxin-antitoxin expression among drug-susceptible and drug-resistant clinical isolates of mycobacterium tuberculosis
    Hossein Kazemian, Hamid Heidari, Jalil Kardan-Yamchi, Sobhan Ghafourian, Iraj Pakzad, Ebrahim Kouhsari, Hasan Valadbeigi, Nourkhoda Sadeghifard
    Advances in Respiratory Medicine, 2021
  • Neutrophil-to-Lymphocyte Ratio as a Poor Prognostic Factor in Iranian COVID-19 Patients
    Ebrahim Kouhsari, Nourkhoda Sadeghifard, Mohammad Karimian, Hojjat Sayyadi, Ali Nazari, Ali Mozafari, Hossein Kazemian, Hassan Valadbeigi, Mohammad Kaffashian
    Clinical Laboratory, 2021
  • Antimicrobial resistance and genetic analysis of multi-drug resistant Klebsiella pneumoniae isolates by pulsed-field gel electrophoresis
    Marya Teimour pour, Ali Gheysarzadeh, Iraj Pakzad, Hassan Valadbeigi, Abbas Maleki, Nourkhoda Sadeghifard
    Gene Reports, 2020
  • Molecular characteristics, antimicrobial resistance profiles, and antibiotic resistance determinants in uropathogenic fluoroquinolone resistant-Escherichia coli isolates
    Hassan Valadbeigi, Masoumeh HatamiLak, Abbas Maleki, Ebrahim Kouhsari, Nourkhoda Sadeghifard
    Gene Reports, 2020
  • Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli Isolates
    Hossein Kazemian, Hamid Heidari, Roya Ghanavati, Sobhan Ghafourian, Fateme Yazdani, Nourkhoda Sadeghifard, Hasan Valadbeigi, Abbas Maleki, Iraj Pakzad
    Medical Principles and Practice, 2019
  • Molecular analysis of uropathogenic E.Coli isolates from urinary tract infections
    Hassan Valadbeigi, Elham Esmaeeli, Sobhan Ghafourian, Abbas Maleki, Nourkhoda Sadeghifard
    Infectious Disorders Drug Targets, 2019
  • Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202
    Ali Gheysarzadeh, Nourkhoda Sadeghifard, Loghman Afraidooni, Farahnaz Pooyan, MohammadReza Mofid, Hassan Valadbeigi, Hadi Bakhtiari, Sattar Keikhavani
    Journal of Research in Medical Sciences, 2018
  • What about urinary tract infections and its antibiotic resistance bacteria in Ilam, Iran?
    Khadijeh Esmaili, Reza Mohebi, Nourkhoda Sadeghifard, Morovat Taherikalani, Iraj Pakzad, Abbas Maleki, Hasan Valadbeigi, Sobhan Ghafourian
    Infectious Disorders Drug Targets, 2018
  • The prevalence of pilA and algD virulence genes in Pseudomonas aeruginosa urinary tract and tracheal isolates
    Hassan Valadbeigi, Nourkhoda Sadeghifard, Majid B. Salehi
    Infectious Disorders Drug Targets, 2017
  • Assessment of biofilm formation in Pseudomonas aeruginosa by antisense mazE-PNA
    Hassan Valadbeigi, Nourkhoda Sadeghifard, Majid Baseri Salehi
    Microbial Pathogenesis, 2017
  • The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae
    Tropical Biomedicine, 2016
  • Enterococcus faecalis as multidrug resistance strains in clinical isolates in Imam Reza Hospital in Kermanshah, Iran
    F. Mohammadi, S. Ghafourian, R. Mohebi, M. Taherikalani, I. Pakzad, H. Valadbeigi, V. Hatami, N. Sadeghifard
    British Journal of Biomedical Science, 2015
  • Genomic diversity and virulence genes among clinical isolates of Pseudomonas aeruginosa
    Hasan Valadbeigi, Robab Tabatabaei, Abbas Malek, Zamberi Sekawi, Mohammad Raftari, Kolsoom Parvaneh, Sobhan Ghafourian, Nourkhoda Sadeghifard
    Clinical Laboratory, 2014
  • Molecular characterization of AmpC β-lactamases among Klebsiella pneumoniae isolated from Ilam and Tehran hospitals, from Iran
    Journal of Pure and Applied Microbiology, 2014
  • Diversity of aminoglycoside modifying enzyme genes among multidrug resistant Acinetobacter baumannii genotypes isolated from nosocomial infections in Tehran hospitals and their association with class 1 integrons
    Khairollah Asadollahi, Morovat Taherikalani, Abbas Maleki, Eshrat Alizadeh, Hasan Valadbaigi, Setareh Soroush, Hossain Maleki, Parisa Asadollahi, Mohammad Emaneini
    Acta Microbiologica Et Immunologica Hungarica, 2011

RECENT SCHOLAR PUBLICATIONS

  • Molecular Characterizations of Carbapenem Resistance and Colistin Heteroresistance in Multidrug-Resistant Acinetobacter baumannii
    N Omidi, E Kouhsari, BS Kalani, VH Kaviar, S Khoshnood, H Valadbeigi, ...
    Current Microbiology 83 (6), 349 , 2026
    2026
  • Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions
    SA Hosseini, H Valadbeigi, SM Khoshnazar, S Khoshnood, S Falahi, ...
    Pharmacology Research & Perspectives 14 (3), e70257 , 2026
    2026
  • Injectable hydrogel and its potential therapy for peri-implantitis
    F Feili, H Valadbeigi, B Negahdari, S Khooshnod, A Maleki, MH Haddadi
    International Journal of Polymeric Materials and Polymeric Biomaterials 75 … , 2026
    2026
  • Understanding the Molecular Pathways of Colistin Heteroresistance in Multidrug-Resistant Acinetobacter baumannii
    N Omidi, E Kouhsari, BS Kalani, VH Kaviar, S Khoshnood, H Valadbeigi, ...
    2025
  • Advances in aptamer technology and its updated applications in gastric cancer
    SA Hosseini, AR Nejad, H Valadbeigi, MH Haddadi, M Bazdar
    Analytical Biochemistry 706, 115950 , 2025
    2025
  • Evaluation of the Therapeutic Effects of Docosahexaenoic Acid on Aspirin-Induced Gastric Ulcer Healing and Oxidative Stress Markers in Rats
    H Valadbeigi, MH Haddadi
    Journal of Health Sciences Perspective 1 (4), 1-13 , 2025
    2025
  • Assessment of Hypervirulent Klebsiella pneumoniae Isolates Using Multilocus Sequence Typing in West of Iran
    MH Haddadi, N Sadeghifard, S Khoshnood, A Maleki, S Ghafourian, ...
    MicrobiologyOpen 14 (4), e70049 , 2025
    2025
    Citations: 1
  • Systematic review and meta-analysis of colistin heteroresistance in Klebsiella pneumoniae isolates
    S Khoshnood, MH Haddadi, N Sadeghifard, A Maleki, E Kouhsari, ...
    BMC Infectious Diseases 25 (1), 207 , 2025
    2025
    Citations: 7
  • Investigation prevalence of Colistin heteroresistant in Klebsiella pneumonia isolates, systematic review and meta-analysis.
    H Valadbeigi, E Kouhsari, N Sadeghifard, L Molaei, A Maleki
    Technology and Research Information System 1403 (4), 0-0 , 2025
    2025
  • Identification of Antimicrobial Resistance Patterns, Type VI Secretion System, and Virulence Factors in Clinical Isolates of Klebsiella pneumoniae : A Cross …
    MH Haddadi, E Taki, A Maleki, J Mashhadi, F Shahi, M Koupaei, ...
    International Journal of Microbiology 2025 (1), 9634257 , 2025
    2025
    Citations: 3
  • Mixed oral biofilms are controlled by the interspecies interactions of Fusobacterium nucleatum
    H Valadbeigi, S Khoshnood, B Negahdari, A Maleki, M Mohammadinejat, ...
    Oral Diseases 30 (6), 3582-3590 , 2024
    2024
    Citations: 12
  • The evaluation of antibacterial effect of metformin-amoxicillin loaded chitosan-alginate nanoparticles against Helicobacter pylori in rat model
    N Sadeghifard, H Valadbeigi, S Khoshnood
    Technology and Research Information System 1402 (3), 0-0 , 2023
    2023
  • Evaluation of effect ZnO nanoparticle on biofilm formation and and genes expression of toxin antitoxin system among clinical isolates of pseudomonas aeruginosa
    H Valadbeigi, N Sadeghifard, S Ghafourian, A Maleki, MH Haddadi
    Technology and Research Information System 1402 (3), 0-0 , 2023
    2023
  • Effect of ZnO nanoparticles on biofilm formation and gene expression of the toxin-antitoxin system in clinical isolates of Pseudomonas aeruginosa
    H Valadbeigi, N Sadeghifard, VH Kaviar, MH Haddadi, S Ghafourian, ...
    Annals of Clinical Microbiology and Antimicrobials 22 (1), 89 , 2023
    2023
    Citations: 46
  • Evaluation of the effect of ZnO nanoparticles on biofilm formation and gene expression of the toxin-antitoxin system in clinical isolates of Pseudomonas aeruginosa
    H Valadbeigi, N Sadeghifard, VH Kaviar, MH Haddadi, S Ghafourian, ...
    2023
  • Evaluation of the patients’ conditions with respiratory tract infections and interventions to prevent taking antibiotics in these patients
    N Sadeghifard, S Ghafourian, J Mohamadi, A Nazari, M Shahmari, ...
    Journal of Ilam University of Medical Sciences: Volume 31 (1) , 2023
    2023
    Citations: 1
  • Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model
    H Valadbeigi, S Khoshnood, B Negahdari, MA Abdullah, MH Haddadi
    BioMed Research International 2023 (1), 5583286 , 2023
    2023
    Citations: 13
  • Prevalence of Tigecycline-resistant strains in clinical isolates of Acinetobacter baumannii and evaluation of their genetic association using multilocus sequence typing (MLST …
    A Maleki, N Sadeghifard, V Hassankaviar, H Valadbeigi
    Technology and Research Information System 5 (3), 0-0 , 2022
    2022
  • Molecular typing and antibiotic resistance patterns among clinical isolates of Acinetobacter baumannii recovered from burn patients in Tehran, Iran
    A Maleki, VH Kaviar, M Koupaei, MH Haddadi, BS Kalani, H Valadbeigi, ...
    Frontiers in microbiology 13, 994303 , 2022
    2022
    Citations: 20
  • The prevalence of heteroresistance to clarithromycin and metronidazole in Helicobacter pylori: systematic review and meta-analysis
    H Valadbeigi, E Kouhsari, A Khadiv, H Sayadi, N Sadeghifard
    Technology and Research Information System 5 (1), 0-0 , 2022
    2022

MOST CITED SCHOLAR PUBLICATIONS

  • Phenotypic and genotypic characterization of ESBL-, AmpC-, and carbapenemase-producing Klebsiella pneumoniae and Escherichia coli isolates
    H Kazemian, H Heidari, R Ghanavati, S Ghafourian, F Yazdani, ...
    Medical Principles and Practice 28 (6), 547-551 , 2019
    2019
    Citations: 117
  • Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202
    A Gheysarzadeh, N Sadeghifard, L Afraidooni, F Pooyan, MR Mofid, ...
    Journal of research in medical sciences 23 (1), 69 , 2018
    2018
    Citations: 101
  • Diversity of aminoglycoside modifying enzyme genes among multidrug resistant Acinetobacter baumannii genotypes isolated from nosocomial infections in Tehran …
    K Asadollahi, M Taherikalani, A Maleki, E Alizadeh, H Valadbaigi, ...
    Acta microbiologica et immunologica Hungarica 58 (4), 359-370 , 2011
    2011
    Citations: 51
  • Effect of ZnO nanoparticles on biofilm formation and gene expression of the toxin-antitoxin system in clinical isolates of Pseudomonas aeruginosa
    H Valadbeigi, N Sadeghifard, VH Kaviar, MH Haddadi, S Ghafourian, ...
    Annals of Clinical Microbiology and Antimicrobials 22 (1), 89 , 2023
    2023
    Citations: 46
  • Heteroresistance to clarithromycin and metronidazole in patients with a Helicobacter pylori infection: a systematic review and meta-analysis
    E Kouhsari, N Sadeghifard, A Khadiv, H Sayadi, T Amiriani, S Ghafourian, ...
    Annals of Clinical Microbiology and Antimicrobials 21 (1), 19 , 2022
    2022
    Citations: 38
  • Molecular typing and antibiotic resistance patterns among clinical isolates of Acinetobacter baumannii recovered from burn patients in Tehran, Iran
    A Maleki, VH Kaviar, M Koupaei, MH Haddadi, BS Kalani, H Valadbeigi, ...
    Frontiers in microbiology 13, 994303 , 2022
    2022
    Citations: 20
  • The association of biofilm formation and sub-minimal inhibitory concentrations of antimicrobial agents
    S Hemati, N Sadeghifard, S Ghafurian, F Maleki, Z Mahdavi, ...
    J Bas Res Med Sci 3 (1), 26-30 , 2016
    2016
    Citations: 19
  • Assessment of biofilm formation in Pseudomonas aeruginosa by antisense mazE-PNA
    H Valadbeigi, N Sadeghifard, MB Salehi
    Microbial pathogenesis 104, 28-31 , 2017
    2017
    Citations: 17
  • Enterococcus faecalis as multidrug resistance strains in clinical isolates in Imam Reza Hospital in Kermanshah, Iran
    F Mohammadi, S Ghafourian, R Mohebi, M Taherikalani, I Pakzad, ...
    British journal of biomedical science 72 (4), 182-184 , 2015
    2015
    Citations: 14
  • Genomic diversity and virulence genes among clinical isolates of Pseudomonas aeruginosa
    H Valadbeigi, RR Tabatabaei, A Malek, Z Sekawi, M Raftari, K Parvaneh, ...
    Clin Lab 60 (1), 363-7 , 2014
    2014
    Citations: 14
  • Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model
    H Valadbeigi, S Khoshnood, B Negahdari, MA Abdullah, MH Haddadi
    BioMed Research International 2023 (1), 5583286 , 2023
    2023
    Citations: 13
  • A study on the frequency of toxin A, alginate genes, and of clinical Pseudomonas aeroginosa strains
    H Valadbeigi, N Sadeghifard, TR RAFIEI, A Maleki
    Journal of Ilam University of Medical Sciences 20 (1), 58-64 , 2012
    2012
    Citations: 13
  • Mixed oral biofilms are controlled by the interspecies interactions of Fusobacterium nucleatum
    H Valadbeigi, S Khoshnood, B Negahdari, A Maleki, M Mohammadinejat, ...
    Oral Diseases 30 (6), 3582-3590 , 2024
    2024
    Citations: 12
  • Comparison of toxin-antitoxin expression among drug-susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis
    H Kazemian, H Heidari, J Kardan-Yamchi, S Ghafourian, I Pakzad, ...
    Advances in Respiratory Medicine 89 (2), 110-114 , 2021
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    2020
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    BMC Infectious Diseases 25 (1), 207 , 2025
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  • Molecular analysis of uropathogenic E. coli isolates from urinary tract infections
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    Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious … , 2019
    2019
    Citations: 7
  • The prevalence of pilA and algD virulence genes in Pseudomonas aeruginosa urinary tract and tracheal isolates
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