Basma Al-Najjar is a lecturer at the department of pharmacy with industrial experience. She took her MSc at University of Central Lancashire, United Kingdom late 2013. Her MSc work involved the preparation of proliposomes, which forms a drug carrier upon delivery to the lungs. She has a broad pharmaceutical background in areas of formulation development, material science and manufacturing. She worked in a pharmaceutical formulation company (Alafrah pharmaceutical company) as a formulation scientist for a while until she joined Alrafidain University College 2014. Dr Basma teaches on a variety of modules. She is involved in teaching the principles of pharmaceutical formulations, pharmaceutical technology and industrial pharmacy to BSc students at undergraduate level. Dr Basma is research active within the area of pharmaceutics and supervise several BSc graduation projects each year.
EDUCATION
BSc Pharmacy, Amman Ahliya University
MSc Industrial pharmacy, University of Central Lancashire
RESEARCH INTERESTS
Pharmaceutical formulations, pharmaceutical technology and industrial pharmacy
6
Scopus Publications
27
Scholar Citations
3
Scholar h-index
1
Scholar i10-index
Scopus Publications
Preparation and Characterization of Apixaban Cocrystals with Coformers for Improving Physical Properties Basma Yahya Al-Najjar, Ishraq Kadhim Abbas, Mowafaq Mohammed Ghareeb Al Rafidain Journal of Medical Sciences, 2024 Background: Cocrystals are stoichiometric, multicomponent crystalline materials composed of an active pharmaceutical ingredient (API) and a coformer arranged in a crystalline structure. Apixaban (APX) is an oral blood thinner that has a low aqueous solubility of 0.028mg/mL at 24 °C and a weak oral bioavailability of about 50% for doses below 10 mg, decreasing as doses above 25 mg are taken. Objectives: To develop and assess APX cocrystal to improve its solubility. Methods: Cocrystals of APX with diverse coformers were synthesized using the solvent evaporation technique in varying molar ratios. The structure of the synthesized cocrystals was validated by DSC, PXRD, and FTIR analyses. Saturation solubility of APX and cocrystals in water was also investigated. Results: APX cocrystals with diverse coformers exhibited distinct physicochemical features. The co-crystal of APX with oxalic acid at a 1:1 ratio exhibited a 2.54-fold enhancement in solubility relative to that of pure APX in water. Each coformer enhanced the solubility of the APX co-crystals. The FTIR spectra of the cocrystals indicated no interaction between the APX and the coformers. The DSC analysis revealed distinct endothermic peaks corresponding to its melting point, indicating the development of cocrystals. The PXRD diffractogram demonstrated fluctuation of 2 theta values of peaks and confirmed cocrystallization of APX. Conclusions: Cocrystallization may serve as a potential method to improve the solubility of APX.
Solid lipid nanoparticles delivery systems for colon cancer chemotherapy: A critical review B. Y. Al-najjar, S. Hussain Systematic Reviews in Pharmacy, 2020 Therapeutic approaches for targeting colon cancers are currently of significant importance important because of possible remission, reduction of cancer metastases, and increased success pf surgery or radiotherapy. Colonic drug delivery is becoming the increasingly preferred route for drug administration; however, it has many limitations that can be avoided by the use of proper carrier systems. Currently, many solid lipid nanoparticle systems (SLNs) were developed to enable the formulation of hydrophobic and poorly water-soluble drugs including those utilized as colonic drug delivery systems. They have many advantages including high bioavailability, high biocompatibility, cost-effectiveness, controlled release, physical stability, and safety, besides, avoidance of using organic solvents and capability of large-scale production and sterilization. Various studies provide important insights into the use of SLN delivery system to treat colon cancer. However, there is a general lack of data from clinical trials and further studies are recommended to evaluate SLNs in animal models.
Preparation of inhalable salbutamol proliposome using different core carriers and investigate the impact of simulated lung fluid use in evaluation B. Y. Al-najjar, M. M. Ghareeb Systematic Reviews in Pharmacy, 2020 Objective: Pro-liposomes are free flowing precursor of liposomes. Liposome low stability can overcome by preparation of Pro-liposomes as high stability precursor of liposome produced upon hydration. Salbutamol sulphate is bronchodilator widely used for the treatment of asthma. Because of its high water solubility its penetration through lipid barriers is low. The preparation of water soluble drugs as liposomes improves their solubility across biological membranes. Method: Microparticulate sucrose, mannitol, trehalose, and lactose separately as core carriers were prepared using mini spray dryer. Ethanolic lipid (soya phosphatidylcholine) solution having salbutamol sulphate and micro particulate core carriers at 1:5 w/w phospholipid to carrier ratio was spray dry to find proliposomes. The prepared liposomes were evaluated for particle size distribution, polydispersity, Z.P., entrapment capacity, and morphology. This investigation was undertaken to compare the evaluation results of the produced liposomes that hydrated by simulated lung fluids that mimic human interstitial lung fluid and deionized water. Results: Good proliposomes were obtained with different properties using spray drying. The results show that carrier type has significant effect on the properties of prepared liposome. In addition, there are obvious differences in results between liposomes generated in simulated lung fluid and deionized water. Overall, simulated lung fluid had significant effect on liposomes size, polydispersity, zetapotential, and entrapment efficiency but had minimal effect of liposome morphology. Conclusion: It can be concluded that use of simulated lung fluid is preferable than deionized water in evaluation of prepared liposomes.
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry Shaza El Nemr, Basma Yahya Al-Najjar, Huner K. Omer, Abdelbary M. A. Elhissi, Mohamed A. Alhnan Pharmaceutical Development and Technology, 2018 Cremophor EL (CrEL) is commonly used to solubilize paclitaxel (Ptx); a widely established anticancer agent used against many types of cancer. Using laser-based microplate nephelometry, in this work we assessed the precipitation kinetics of Ptx in CrEL-containing formulations upon dilutions with different infusion media or upon introduction into rat plasma. The precipitation profile of Ptx was assessed for a Taxol-like formulation and compared with a preparation with reduced CrEL content. These two formulations were diluted at various ratios in compatible infusion media and with or without rat plasma. The percentages of Ptx precipitated in dilution media and protein-binding in plasma were quantified using HPLC. The findings of turbidity measurements were in good agreement with HPLC. Despite the presence of albumin, it was possible to assess turbidity within infusion solutions and predict Ptx precipitation. Upon addition to plasma, no precipitation in Taxol-like formulation occurred after 2 h. In contrast, precipitation occurred immediately in CrEL-reduced formulation. It is possible that the high percentage of protein-bound Ptx in plasma (98.5–99.2%) has inhibited drug precipitation. Turbidity measurements using laser nephelometry can provide a rapid screening tool when developing intravenous formulations for poorly soluble drugs, such as Ptx and assess its stability upon dilution in animal plasma.
Chitosan microspheres for the delivery of chemotherapeutic agents: Paclitaxel as a model Basma Yahya Al-najjar, Saad Abdulrahman Hussain Asian Journal of Pharmaceutical and Clinical Research, 2017 Chitosan has unique physicochemical and biological features that suggest it as a good candidate for the development of safe and effective drug delivery systems. Linking drug molecules with chitosan through a functional spacer enables formulation of prodrugs that have appropriate pharmacological activities at specific desired sites. The development of formulations of targeted delivery systems for the chemotherapeutic agents, especially those with unfavorable pharmacokinetic features, like paclitaxel (PTX), can potentially alleviate the systemic cytotoxicity as well as directing therapy to the specific lesions. The main aim of this literature review is to critically evaluate the use of chitosan microspheres as a drug delivery system to enhance PTX distribution and efficacy in specific targeted sites.
RECENT SCHOLAR PUBLICATIONS
Preparation and Characterization of Apixaban Cocrystals with Coformers for Improving Physical Properties BY Al-Najjar, IK Abbas, MM Ghareeb Al-Rafidain Journal of Medical Sciences (ISSN 2789-3219) 7 (2), 120-126 , 2024 2024
Preparation and In vitro characterization of Sildenafil citrate Oral gel Preparation and In vitro characterization of Sildenafil citrate Oral gel BYANMM Mohammed International Journal of pharmaceutical research 12 (supplementary issue 1 … , 2020 2020
Preparation of Inhalable Salbutamol Proliposome Using Different Core Carriers and Investigate the Impact of Simulated Lung Fluid Use in Evaluation BYAN Mowafaq M. Ghareeb Systematic reviews in pharmacy 11 (4), 629-639 , 2020 2020 Citations: 4
Preparation and in vitro Characterization of Sildenafil Citrate Oral Gel. BY AL-NAJJAR, MM MOHAMMED International Journal of Pharmaceutical Research (09752366) , 2020 2020
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry S El Nemr, BY Al-Najjar, HK Omer, AMA Elhissi, MA Alhnan Pharmaceutical development and technology 23 (1), 67-75 , 2018 2018 Citations: 4
Chitosan microspheres for the delivery of chemotherapeutic agents: paclitaxel as a model BY Al-najjar, SA Hussain Asian J Pharm Clin Res 10 (8), 1-5 , 2017 2017 Citations: 19
MOST CITED SCHOLAR PUBLICATIONS
Chitosan microspheres for the delivery of chemotherapeutic agents: paclitaxel as a model BY Al-najjar, SA Hussain Asian J Pharm Clin Res 10 (8), 1-5 , 2017 2017 Citations: 19
Preparation of Inhalable Salbutamol Proliposome Using Different Core Carriers and Investigate the Impact of Simulated Lung Fluid Use in Evaluation BYAN Mowafaq M. Ghareeb Systematic reviews in pharmacy 11 (4), 629-639 , 2020 2020 Citations: 4
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry S El Nemr, BY Al-Najjar, HK Omer, AMA Elhissi, MA Alhnan Pharmaceutical development and technology 23 (1), 67-75 , 2018 2018 Citations: 4
Preparation and Characterization of Apixaban Cocrystals with Coformers for Improving Physical Properties BY Al-Najjar, IK Abbas, MM Ghareeb Al-Rafidain Journal of Medical Sciences (ISSN 2789-3219) 7 (2), 120-126 , 2024 2024
Preparation and In vitro characterization of Sildenafil citrate Oral gel Preparation and In vitro characterization of Sildenafil citrate Oral gel BYANMM Mohammed International Journal of pharmaceutical research 12 (supplementary issue 1 … , 2020 2020
Preparation and in vitro Characterization of Sildenafil Citrate Oral Gel. BY AL-NAJJAR, MM MOHAMMED International Journal of Pharmaceutical Research (09752366) , 2020 2020
Publications
El Nemr S, Al-Najjar BY, Omer HK, Elhissi AM, Alhnan MA. Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry. Pharmaceutical development and technology. 2018 Jan 2;23(1):67-75.
Al-najjar BY, Hussain SA. Chitosan microspheres for the delivery of chemotherapeutic agents: paclitaxel as a model. Asian J Pharm Clin Res. 2017;10(8):1-5.
Al-Najjar BY, Ghareeb MM. Preparation of Inhalable Salbutamol Proliposome Using Different Core Carriers and Investigate the Impact of Simulated Lung Fluid Use in Evaluation. Systematic Reviews in Pharmacy. 2020;11(4):629-39.
Al-Najjar BY, Hussain SA. Solid Lipid Nanoparticles Delivery Systems for Colon Cancer Chemotherapy: A critical review. Systematic Reviews in Pharmacy. 2020; 11(1):1-6.
Al-Najjar BY, Mohammed MM. Preparation and In vitro characterization of Sildenafil citrate Oral gel Preparation and In vitro characterization of Sildenafil citrate Oral gel. International Journal of pharmaceutical research. 2020;12(supp 1):1485-90.
