master of microbiology
worked at center liver disease and PCR deciner
5
Scopus Publications
18
Scholar Citations
2
Scholar h-index
1
Scholar i10-index
Scopus Publications
Role of 11β-hydroxysteroid dehydrogenase gene polymorphisms rs846910 and rs12086634 in the etiology of hepatocellular carcinoma Ahmed Mudher Al-Khaykanee, Soura Alaa Hussein, Z Muhsen M Ali, and Biologica Nyssana, 2025 In Asia, the most frequent cause of hepatocellular carcinoma (HCC) is chronic hepatitis B. The hepatitis B virus's (HBV) genomic integration is probably a precursor to carcinogenesis. The integrated HBV genome may directly activate nearby cellular genes to give the liver cells a selective growth advantage. Our study's goal was to determine if genetic variants in 11β-HSD1, rs846910 and rs12086634 could be linked to chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). 150 samples were collected from people suffering from hepatitis B with HCC, HCC, and healthy people. The samples were genotyped for 11β HSD1 (rs846910 and rs12086634) using allele-specific real-time PCR. After performing genotyping of the 11β-HSD1 gene using real-time PCR, both alleles G and A of rs846910 were found to be more prevalent in the two groups of hepatocellular carcinoma and hepatitis B. This gives a clear indication about the possibility of contracting hepatocellular carcinoma and hepatitis B. A different result was found than previously, as the TT genotype of rs12086634 showed a protective effect against hepatocellular carcinoma and hepatitis B virus infection, while the AG genotype of rs846910 increased the risk of hepatocellular carcinoma. These genetic variations are clearly significant biomarkers for hepatocellular carcinoma.
Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients Z. Muhsen M Ali, H. Ghaith Sachit, M. Jaafar Hussein, S. M. Mohammed Ali, S. H. Mohammed Al-Alwany, et al. Archives of Razi Institute, 2022 Colorectal cancer is ranked to have high mortality among most malignancies worldwide. In the adult population, the seroprevalence rates of the John Cunningham virus (JCV) range from 70% to 90%. Recently the association for JCV in many malignant tumours have been reported worldwide, including colonic and rectum cancers. Interleukin-1β (IL-1β) can promote tumour growth where it is abundant in the tumour microenvironment, and its up-regulation is considered a poor prognostic feature in different types of solid tumours, including colon malignancies. One hundred tissue biopsies belonged to 50 patients with colorectal cancers and 30 benign colonic tumour patients, and 20 colorectal control tissues were enrolled in this study. JCV was detected via chromogenic in situ hybridization (CISH), while IL-1 beta was detected by immunohistochemistry (IHC). The recorded data showed that 21 out of 50 (42%) tissue samples with colorectal carcinoma showed positive CISH reactions for JCV DNA in this study. The benign colorectal tumours group revealed positive signals in 2 out of 30 tissues representing 6.7% of this group. Lastly, no control tissues showed positive signals for the JCV -CISH test. The positive signals of IL-1 Beta-IHC detection were found in 26 out of 50 (52 %) colorectal carcinoma tissues, while in the benign colorectal tumour was 43.3% (13 out of 30) and in AHC was 20% (4 out of 20 tissues). The high rates of JCV infection in this group of Iraqi patients with colonic adenocarcinoma in concordance with IL-1 Beta expression could play an essential role in the development and progression of these malignant tumours along with benign colonic tumours. To analyze the concordant expression of IL-1 beta gene and JCV in issues from a group of Iraqi patients with colonic adenocarcinomas.
The effect of different decontaminants on green vegetable foods collected from Iraqi stores Current Pediatric Research, 2021
DNA REPAIR PROTEIN XRCC1 GENETIC VARIATIONS AND THEIR CORRELATION WITH THE RISK OF BREAST CANCER SAHZMMA Ahmed Mudher Al- Khaykanee1* WORLD JOURNAL OF ADVANCE HEALTHCARE RESEARCH , 2025 2025.0
Correlation between hepatitis B virus with chronic kidney disease AG Hamed, ZMM Ali Open Access Research Journal of Biology and Pharmacy 13 (1), 015-020 , 2025 2025.0
Molecular interplay of John Cunningham virus with interleukin 1 beta in colorectal carcinomatous tissues from a group of Iraqi patients MA SH, MAA SH Archives of Razi Institute 77 (6), 2299 , 2022 2022.0 Citations: 2
Non-coding RNAs, another side of immune regulation during triple-negative breast cancer MW Alghazali, HRAK Al-Hetty, ZMM Ali, MM Saleh, AAJ Suleiman, ... Pathology-Research and Practice 239, 154132 , 2022 2022.0 Citations: 11
Effect of washing and prevalence of bacteria in leafy vegetable foods collected from Iraqi markets. HK Turki, ZMM Ali, SA Hussein 2020.0 Citations: 3
A molecular implicatory propositioning roles for human cytomegalovirus and p16 gene expression in oral squamous cellular carcinogenesis HG Sachit, TF Almahbobi, ZMM Ali, SHM Ali, SHM Al-Alwany J. Pure Appl. Microbiol 13, 2333-2342 , 2019 2019.0 Citations: 2
The effect of different decontaminants on green vegetable foods collected from Iraqi stores. HK Turki, ZMM Ali, AH Saleem
MOST CITED SCHOLAR PUBLICATIONS
Non-coding RNAs, another side of immune regulation during triple-negative breast cancer MW Alghazali, HRAK Al-Hetty, ZMM Ali, MM Saleh, AAJ Suleiman, ... Pathology-Research and Practice 239, 154132 , 2022 2022.0 Citations: 11
Effect of washing and prevalence of bacteria in leafy vegetable foods collected from Iraqi markets. HK Turki, ZMM Ali, SA Hussein 2020.0 Citations: 3
Molecular interplay of John Cunningham virus with interleukin 1 beta in colorectal carcinomatous tissues from a group of Iraqi patients MA SH, MAA SH Archives of Razi Institute 77 (6), 2299 , 2022 2022.0 Citations: 2
A molecular implicatory propositioning roles for human cytomegalovirus and p16 gene expression in oral squamous cellular carcinogenesis HG Sachit, TF Almahbobi, ZMM Ali, SHM Ali, SHM Al-Alwany J. Pure Appl. Microbiol 13, 2333-2342 , 2019 2019.0 Citations: 2
DNA REPAIR PROTEIN XRCC1 GENETIC VARIATIONS AND THEIR CORRELATION WITH THE RISK OF BREAST CANCER SAHZMMA Ahmed Mudher Al- Khaykanee1* WORLD JOURNAL OF ADVANCE HEALTHCARE RESEARCH , 2025 2025.0
Correlation between hepatitis B virus with chronic kidney disease AG Hamed, ZMM Ali Open Access Research Journal of Biology and Pharmacy 13 (1), 015-020 , 2025 2025.0
The effect of different decontaminants on green vegetable foods collected from Iraqi stores. HK Turki, ZMM Ali, AH Saleem
