Brahmayya has been working as Research Associate in Central Tribal University of AP (CTUAP) since 2022. He received his Master’s degree in Chemistry in 2007 and Ph.D. in 2013 from Andhra University, Visakhapatnam. He has been a worked as NSC Post Doctoral Fellow at the HungKuang University, Taichung, Taiwan (20013), MOST-Postdoctoral Fellow at National Chung Hsing University (Below 500 Rank), Taiwan (2014-2017), CGMH-MOST Post Doctoral Fellow, Chang Gung Memorial Hospital-CGU school of Medicine (2017-2018, (World Rank 105) and a MOST-Postdoctoral Fellow at Academia Sinica (World Rank 22 ), Taiwan (2019). He is a recipient of the Best Research Article awardee in 2018. His research interests include Total Synthesis, Medicinal chemistry, Nanomaterials, Catalysis.
EDUCATION
M.Sc, Ph.D, M.B.A, PDF, PDF, PDF, PDF
RESEARCH INTERESTS
Organic Chemistry
Materials Chemistry CO2 Reduction
Traditional medicine
Chemical Biology
Carbon Dot-Based Electrochemical and Optical Sensors for Pharmaceutical Analysis and Point-of-Care Diagnostics Ganesh Gollavelli, Chiranjib Patra, Chiranjeevi Korupalli, Manuri Brahmayya, Yong-Chen Ling Biosensors, 2026 Because of their special optical and electrochemical characteristics, superior biocompatibility, adjustable surface chemistry, and inexpensive, scalable synthesis, carbon dots (CDs), including carbon quantum dots and graphene quantum dots, have become powerful and adaptable nanomaterials for advanced pharmaceutical analysis and other toxicants. The sensitive and selective detection of active pharmaceutical substances, degradation products, contaminants, biomarkers, and therapeutic medication levels in complex matrices has shown great promise in recent years with CD-based nanobiosensors. The development of various sensing platforms, such as electrochemical, optical, and dual-mode biosensors, as well as integration into microfluidic, paper-based, and wearable point-of-care (POC) devices, is made possible by their intrinsic fluorescence, effective electron transfer capacity, and ease of functionalization. With an emphasis on sensing mechanisms, biorecognition techniques, and analytical performance, this study critically reviews current developments in CD-based nanobio/chemosensors for pharmaceutical analysis. It includes a thorough discussion of important applications in drug development, stability research, therapeutic drug monitoring, and drug quality control. Along with new developments like green synthesis, AI-assisted signal processing, and smart sensing platforms, current issues with reproducibility, standardization, biocompatibility, and regulatory validation are highlighted. Lastly, prospects for the industrial application and clinical translation of CD-based nanobiosensors are discussed.
Nano-sulfonated Graphene Oxide: A Metal-free Catalyst for the Synthesis of Benzimidazoles and Antimicrobial Activities V Murali Krishna Madasu, M Padma, Jyotsna Cherukuri, Kadali Yashoda, E Vijaya, CH Praveen, Manuri Brahmayya Journal of Environmental Nanotechnology, 2026 Nano sulfonated graphene oxide (SGO) was synthesized with slight modifications to previously reported methods. An efficient and ecofriendly protocol was developed for the synthesis of benzimidazole derivatives using o-phenylenediamine and D-glucose as substrates, employing a metal-free sulfonated graphene oxide carbocatalyst. A diverse range of benzimidazole derivatives was obtained in moderate to high yields (up to 94%) using a sustainable and readily available C1 source under sonication conditions. The reaction, carried out in ethanol with tertiary-butyl hydroperoxide, provides a general and novel approach for benzimidazole synthesis via a carbonylation pathway. The process is facilitated by a cost-effective and environmentally benign SGO nanocatalyst, enabling the formation of valuable products in excellent yields. The synthesized benzimidazole derivatives exhibited strong antibacterial activity, with inhibition rates of 99% to 100% against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes.
Sulfonated Graphene Oxide Catalyzed Transformation of Pyrazole-Oxazolidine Derivatives and their Antimicrobial Activities V. Murali Krishna Madasu, Manuri Brahmayya, S. Deepthi, A. Harinath, Lakshmi Rekha Buddiga, J. Chandra Sekhara Rao, M. Padma, Praveen Choppara, D. Samsonu, A. Venkateswara Rao Asian Journal of Chemistry, 2026 In this work, biologically active novel (E)-5-((1-phenyl-3-(4-R-phenyl)-1H-pyrazol-4-yl)methylene)-3-(4-chlorophenyl)oxazolidine-2,4-dione derivatives are synthesized and characterized. Initially, 5-azanyl(4-chlorophenyl)carbamate (3) was obtained from 4-chloroaniline (1) via carbonation with CO2 (2) in liquid ammonia, followed by O-carboxymethylation with sodium 2-chloroacetate to afford sodium 2-(((4-chlorophenyl)carbamoyl)oxy)acetate (4). Subsequently, compound 4 was cyclized to yield 3-(4-chlorophenyl)oxazolidine-2,4-dione (5) using sulfonated graphene oxide (SGO) as metal free nanocatalyst. Later, benzohydrazide (6) was condensed with various types of carboxylic acids (7) in presence of glacial acetic acid to obtain (E)-(4-R-phenyl)ethylidene hydrazone (8). It is further treated with POCl3 at 80 ºC for 4 h to obtain substituted pyrazole derivatives (9a-h). Finally, substituted pyrazole derivatives (9a-h) treated with sulfonated graphene oxide (SGO) catalyzed product 3-(4-chlorophenyl)oxazolidine-2,4-dione (5) to obtain targeted heterocyclic molecules 10a-h. This protocol demonstrates significant advantages in efficiency, ecological sustainability and catalyst reusability. Furthermore, the synthesized 1,3-oxazolidine-2,4-dione derivatives were evaluated for their antibacterial properties. The findings highlight the catalytic potential of SGO in the synthesis of 1,3-oxazolidine-2,4-dione derivatives as well as in broader applications in green organic transformations.
Synthesis of 1-((5-oxo-4,5-Dihydro-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-3-carboxylic Acid-Application of Antibacterial activity Manuri Brahmayya, Dasi Samsonu, Alaparthi Venkateswara Rao, Nelli Srinivasa Rao, Battula Venkateswara Rao, Huan-Jung Fan Proceedings of the National Academy of Sciences India Section A Physical Sciences, 2019 Synthesis of 1-((5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl) methyl)-1H-1,2,4-triazole-3-carboxylic acid was accomplished starting with the commercially available 1,2,4-triazole-3-carboxylic acid. The conversion of hydrazide and carbon dioxide to 1,3,4-oxadiazole has been explained. Antibacterial activity also studied for some synthesized compounds.
Bone regeneration using adipose-derived stem cells in injectable thermo-gelling hydrogel scaffold containing platelet-rich plasma and biphasic calcium phosphate Han Liao, Ming-Jin Tsai, Manuri Brahmayya, Jyh-Ping Chen International Journal of Molecular Sciences, 2018 For bone regeneration, a biocompatible thermo-gelling hydrogel, hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) (HA-CPN) was used as a three-dimensional organic gel matrix for entrapping rabbit adipose-derived stem cells (rASCs). Biphasic calcium phosphate (BCP) ceramic microparticles were embedded within the gel matrix as a mineralized bone matrix, which was further fortified with platelet-rich plasma (PRP) with osteo-inductive properties. In vitro culture of rASCs in HA-CPN and HA-CPN/PRP/BCP was compared for cell proliferation and osteogenic differentiation. Overall, HA-CPN/PRP/BCP was a better injectable cell carrier for osteogenesis of rASCs with increased cell proliferation rate and alkaline phosphatase activity, enhanced calcium deposition and mineralization of extracellular matrix, and up-regulated expression of genetic markers of osteogenesis. By implanting HA-CPN/PRP/BCP/rASCs constructs in rabbit critical size calvarial bone defects, new bone formation at the defect site was successfully demonstrated from computed tomography, and histological and immunohistochemical analysis. Taken together, by combining PRP and BCP as the osteo-inductive and osteo-conductive factor with HA-CPN, we successfully demonstrated the thermo-gelling composite hydrogel scaffold could promote the osteogenesis of rASCs for bone tissue engineering applications.
Green synthesis & catalytic study of sucrose stabilized Pd nanoparticles in reduction of nitro compounds to useful amines Dasi Samsonu, Manuri Brahmayya, Boddeti Govindh, Y.L.N. Murthy South African Journal of Chemical Engineering, 2018 An efficient chemoselective reduction of aromatic nitro compounds to corresponding amino analogues was achieved using palladium/sucrose (Pd/S) nanoparticles as an eco friendly catalyst, a green approach formate in ethanol at RT. The reductions are fruitfully carried out in presence of various other reducible functional groups such as halo, alkoxy, carbonyl, and cyanide etc. The reactions are worthy and high yielding (100%).
Selective-β-acylation-of-2-substituted aromatic heterocyclic compounds Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
An efficient acetylation of aromatic hetero cyclic compounds: Silica gel as well as silica-ferric oxide supported erbium (III) triflate used as a novel catalyst for first time under solvent free conditions Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
Multi component, one-pot synthesis of (1-(4-(1H-imidazol-1-yl) phenyl)-1, 2-dihydronaptho[1, 2-e] [1, 3]-3-thione and 3-one derivatives under microwaveassisted conditions Der Pharma Chemica, 2013
Microwave assisted synthesis and biological evaluation of flourosubstituted benzimidazole derivatives International Journal of Chemical Sciences, 2011
RECENT SCHOLAR PUBLICATIONS
Carbon Dot-Based Electrochemical and Optical Sensors for Pharmaceutical Analysis and Point-of-Care Diagnostics G Gollavelli, C Patra, C Korupalli, M Brahmayya, YC Ling Biosensors 16 (5), 246 , 2026 2026
Nano-Sulfonated Graphene Oxide: A Metal- Free Catalyst for the Synthesis of Benzimidazoles and Antimicrobial Activities MB V. Murali Krishna Madasu, M. Padma, Jyotsna Cherukuri, Kadali Yashoda, E ... Journal of Environmental Nanotechnology 15 (1), 701-715 , 2026 2026
Green Synthesis of Reduced Graphene Oxide Using Grevillea robusta Leaf Extract: Evaluation for Dye Degradation and Antibacterial Applications CJ Manuri Brahmayya,*, Dasi Samsonu National Conference on SUSTAINABLE CHEMISTRY FOR HEALTH, ENERGY … , 2026 2026
Sulfonated Graphene Oxide (SGO) as a Metal-Free Nanocatalyst for the Synthesis of Benzimidazole contain Benzo[b][1,4]oxazine Hybrids: its antimicrobial activity MP V. Muralikrishna Madasu, Kadali Yashoda, Manuri Brahmayya* DST-SERB/ ANRF Sponsored International Conference On “Eco-Adaptive Research … , 2026 2026
Interfacial polarisation, electrical modulus and relaxation dynamics in composite ceramics for multiferroic applications MB Ganapathi Rao Gajula , Lakshmi Rekha Buddiga , Ganganagunta Srinivas , N ... Journal of Colloid and Interface Science , 2026 2026
Synthesis, Properties and Applications of Graphene Nanomaterials * Dasi Samsonu, Jyotsna Cherukuri, Praveen Choppara, Lakshmi Rekha Buddiga ... Nanotechnology in Plant Science, Chemistry and Physical Science 1 , 2026 2026
Zr/P Co-Doped TiO2 Nanonanocatalyst for Microwave-Assisted Green Synthesis of Bioactive Azlactones: Enhanced Catalytic Performance and Mechanistic Insights LR Buddiga, GR Gajula, M Brahmayya, P Bhanuchander Catalysis Letters 156 (1), 23 , 2026 2026 Citations: 2
Sulfonated graphene oxide catalyzed transformation of pyrazole-oxazoldine derviatives and their antimicrobial activities AVR V.Murali Krishna Madasu, M.Brahmayya, Deepthi Sista, A.Harinath, Lakshmi ... Asian Journal of Chemistry 38 (1), 180-186 , 2026 2026
Synthesis, Characterization,and concentration-dependent Antibacterial and Anti-Tuberculosis Activity of Nickel Based Metal Organic Frame Works MB D.Naga Prasuna, A.Venkateswara Rao International Conference on Emerging thermos Nano AI for Sustainable Future … , 2025 2025
Traditional Medicine and Healing Process M Brahmayya Indhira Gandhi National Open University, IGNOU, New Delhi , 2025 2025
Sulfonated grapheneoxide as a Sustainable Metal Free Acid Catalyst : A Smart Approach for Synthesizing 1, 3, 4-Oxadiazole Derivatives from Carboxylic Acids: Antimicrobial … SI M.V.Murali Krishna, J. Chandrasekhar Rao , Sudarshana Santhosh Kumar ... Discover Catalysis , 2025 2025 Citations: 2
Rational design and synthesis of 1,2,3-Triazole Incorporated oxazolo[5,4-d] pyrimidine derivatives: In-vitro cytotoxicity and In-silico molecular docking simulations SK Baajam Arun, Manuri Brahmayya, Reddymasu Sreenivasulu, Dasari Sravani ... Polycylic Aromatic Compounds , 2025 2025 Citations: 9
Synthesis of flourine substituted benzimidazole-pyrazole molecules and their antimicrobial activities MP V.Murali Krishna Madasua,, Kadali Yasoda, Srinivas Indla , Sudarshana ... African Journal of Biological Sciences 7 (2), 683-695 , 2025 2025
Graphene-Calcium Phosphate Nanocomposites for the sustainability of Bone repair and its Biological Properties MB Adimulam Harinath, G. Nagendra Babu, Tejovathi Bandike, D. Suresh, D.Samsonu African Journal of Biological Sciences 6 (16), 433-446 , 2024 2024
Metal Organic Framework Based Nanofiber Membrane for Waste Water Remediation A.Venkateswara Rao ,D.Naga Prasuna, A.Nagamalli, Dr.Akber Khan, Dr.Mohammad ... Indian Patent , 2024 2024
Phytochemical Screening and Study of Antioxidant, Antibacterial, Antifungal activities for the ethanolic leaf extract of Tinospora Cordifolia M.Brahmayya, V.S.Ram, T.Shyamala, G.Triveni, D.Munikumar V. V.S.Deepak, D.S ... African Journal of Biological Sciences 6 (13), 2694-2707 , 2024 2024
Graphene Calcium Phosphates for Bone Engineering and Their Biological Properties M Brahmayya, AV Rao, HT Liao, JP Chen African Journal of Biological Sciences 6 (12), 2694-2707 , 2024 2024
A method and system for efficient removal of toxic metals using functionalized adsorbents P. Sirisha, M.Brahmayya, Gopal Krishna P, N.Manoj Kumar, GVijayakumar IN Patent App. 202341016847 A , 2023 2023
Nanotechnology-based Coating for Improved Thermal Performance in Solar Water Heaters DRK Dr. J. Surya Kumari,Dr. K. Ramanjaneyulu,Dr. M. Parthasarathy,Dr ... IN Patent App. 202341013797 A , 2023 2023
A novel grapheneoxide-1,3,4-Oxadiazole 2,5-diamine nanomaterial with enhanced bactericide activity M.Brahmayya, DC Yang,YC Fu,SY Li, S.Y Suen Journal of the Taiwan Institute of Chemical Engineers 153 , 2023 2023 Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
Sulfonated reduced graphene oxide catalyzed cyclization of hydrazides and carbon dioxide to 1, 3, 4-oxadiazoles under sonication M Brahmayya, SA Dai, SY Suen Scientific Reports 7 (1), 4675 , 2017 2017 Citations: 73
Bone Regeneration Using Adipose-Derived Stem Cells in Injectable Thermo-Gelling Hydrogel Scaffold Containing Platelet-Rich Plasma and Biphasic Calcium Phosphate H Liao, MJ Tsai, M Brahmayya, JP Chen International Journal of Molecular Sciences 19 (9), 2537 , 2018 2018 Citations: 60
Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus SH Adam, N Giribabu, N Kassim, KE Kumar, M Brahmayya, A Arya, ... Biomedicine & Pharmacotherapy 81, 439-452 , 2016 2016 Citations: 59
Green Synthesis & Catalytic study of Sucrose Stabilized Pd Nanoparticles in Reduction of Nitro Compounds to Useful Amines D Samsonu, M Brahmayya, B Govindh, YLN Murthy South African Journal of Chemical Engineering , 2018 2018 Citations: 50
Synthesis and fungicidal activity of novel 5-aryl-4-methyl-3yl (imidazolidin-1yl methyl, 2-ylidene nitro imine) isoxazoles M Brahmayya, B Venkateswararao, D Krishnarao, S Durgarao, UV Prasad, ... Journal of Pharmacy Research 7 (6), 516-519 , 2013 2013 Citations: 45
Synthesis of 5-substituted-3 H-[1, 3, 4]-oxadiazol-2-one derivatives: a carbon dioxide route (CDR) M Brahmayya, SA Dai, SY Suen RSC advances 5 (80), 65351-65357 , 2015 2015 Citations: 39
Sulfonated graphene oxide-catalyzed N-acetylation of amines with acetonitrile under sonication M Brahmayya, SY Suen, SA Dai Journal of the Taiwan Institute of Chemical Engineers , 2018 2018 Citations: 32
Facile synthesis of 2-benzimidazolones via carbonylation of o-phenylenediamines with CO2 M Brahmayya, SA Dai, SY Suen Journal of CO2 Utilization 22, 135-142 , 2017 2017 Citations: 18
Rational design and synthesis of 1,2,3-Triazole Incorporated oxazolo[5,4-d] pyrimidine derivatives: In-vitro cytotoxicity and In-silico molecular docking simulations SK Baajam Arun, Manuri Brahmayya, Reddymasu Sreenivasulu, Dasari Sravani ... Polycylic Aromatic Compounds , 2025 2025 Citations: 9
Spectroscopic characterization and conductivity of Sn-substituted LiTi 2 (PO 4 ) 3 A Venkateswara Rao, V Veeraiah, AV Prasada Rao, B Kishore Babu, ... Research on Chemical Intermediates 41 (7), 4327-4337 , 2015 2015 Citations: 9
Synthesis of 3, 5-dimethyl-1-prop-2-enylpyrazole under solid–liquid phase transfer catalytic conditions assisted by ultrasonic irradiation—A kinetic study M Brahmayya, ML Wang Journal of the Taiwan Institute of Chemical Engineers 45 (6), 2899-2905 , 2014 2014 Citations: 7
Synthesis of Acetamides from Aryl Amines and Acetonitrile by Diazotization under Metal-Free Conditions YF Zeng, YN Li, NN Zhang, H Kang, P Duan, F Xiao, Y Guo, X Wen Synlett 30 (19), 2169-2172 , 2019 2019 Citations: 6
The novel synthetic route of 3, 5-dimethyl-1-(3-phenylpropyl)-1H-pyrazole under solid–liquid phase transfer catalysis conditions assisted by an ultrasound application—A study … ML Wang, M Brahmayya, YM Hsieh Journal of the Taiwan Institute of Chemical Engineers 57, 54-61 , 2015 2015 Citations: 6
A new and efficient method for the synthesis of 2-N-(aryl)-1, 3, 4-oxadiazole-2, 5-diamine derivatives M Brahmayya, FS Liu, SY Suen, CC Huang, SA Dai, YS Guo, YF Chen Research on Chemical Intermediates, 1-11 , 2015 2015 Citations: 6
Synthesis and Characterizations of Graphite Bisulphate and Its Selective Catalytic Activity in Presence of Cyclo Hexanone for the Acylation of Aromatic Compounds with the … Manuri Brahamyya.,Maw-LingWang International Journal of chemistry 35, 1522-1530 , 2014 2014 Citations: 5
Synthesis of quinolines and their In vitro antioxidant activities under solvent free conditions by using the SiO2-Zn-MgO as a novel and reusable catalyst. M Brahmayya, BV Rao, U Viplavaprasad, MV Rao, KR Babu, BK Babu, ... Journal of Applied Pharmaceutical Science , 2012 2012 Citations: 5
Selective acetylation of aromatic heterocyclic compounds U Vipalavaprasad, M Brahmayya, D Samsonu, K Vijayakumar, ... Scientific Reviews and Chemical Communications 1 (1), 58-62 , 2011 2011 Citations: 5
A novel grapheneoxide-1,3,4-Oxadiazole 2,5-diamine nanomaterial with enhanced bactericide activity M.Brahmayya, DC Yang,YC Fu,SY Li, S.Y Suen Journal of the Taiwan Institute of Chemical Engineers 153 , 2023 2023 Citations: 4
