Joana Ferreira

@cnc.uc.pt

Center for Neuroscience and Cell Biology - CNC / Institute of Interdisciplinary Research - IIIUC
University of Coimbra

Joana Ferreira


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https://researchid.co/jferreira
Joana Ferreira, graduated in Biology in 2006 (University of Coimbra) and completed her PhD in Biosciences, specialty Neurosciences (University of Coimbra) in 2012, under the co-supervision of Ana Luísa Carvalho at the Center for Neuroscience and Cell Biology (University of Coimbra, Portugal) and Ann Marie Craig at the Center for Brain Health (University of British Columbia, Vancouver, Canada). After completing her PhD, she stayed at the Center for Neuroscience and Cell Biology (CNC) as a postdoctoral fellow to complete her studies on the molecular mechanisms of traffic of glutamate receptors. In 2016 she joined the group of Laurent Groc, at the Interdisciplinary Institute for Neuroscience (CNRS, University of Bordeaux, France), to explore the regulation of the nanoscale distribution of NMDA receptors (NMDARs). In 2021 she has joined the CNC-UC as an Assistant Investigator to start her independent line of research on the nanoscale architecture of the synapse and transsynaptic signaling.

EDUCATION

2012 PhD in Biosciences, specialization in Neurosciences, University of Coimbra (Portugal)
2006 Bachelor's in Biology, University of Coimbra (Portugal)

RESEARCH INTERESTS

Neuroscience, Glutamate Receptors, Super-resolution Microscopy, Transsynaptic signalling, Molecular Neuroscience

FUTURE PROJECTS

The study of the novel NMDA receptor-Neurexin-2 interaction and potential role in schizophrenia


Applications Invited
PhD students
23

Scopus Publications

1070

Scholar Citations

17

Scholar h-index

18

Scholar i10-index

Scopus Publications

  • Neurexins, Ephrin receptors, and N-cadherin signaling as emerging mechanisms in synaptic dysfunction and neurodegenerative diseases
    João Gonçalves-Martins, Carlos Cação, Joana S. Ferreira
    Communications Biology, 2026
    Synaptic cell adhesion molecules (SAMs) are essential for axon pathfinding and synaptic establishment during neurodevelopment, bridging the pre- and postsynaptic compartments across the synaptic cleft. While this function is well established, recent evidence has shown these proteins also exert key neuronal functions throughout the neuron’s life, regulating neuronal communication at mature synapses. Given these novel roles, SAMs are emerging as important elements relating to mental health and as significant contributors to age-related diseases, such as neurodegenerative disorders. For insight into this emerging role of SAMs, we focused on three pivotal regulator families of the central nervous system: Neurexins, Ephrin Receptors, and N-cadherins. This review summarizes the emerging roles of three pivotal cell adhesion families of the central nervous system in age-associated neurodegenerative disorders, highlighting new regulatory mechanisms at mature synapses.
  • Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission
    Jeannette Schmidt, Ângela S. Inácio, Joana Ferreira, Débora Serrenho, Renato Socodato, Nuno Beltrão, Luís F. Ribeiro, Paulo Pinheiro, João B. Relvas, Ana Luisa Carvalho
    Communications Biology, 2026
    The aberrant formation and function of neuronal synapses are recognized as major phenotypes in many cases of neurodevelopmental (NDDs) and -psychiatric disorders (NPDs). A growing body of research has identified an expanding number of susceptibility genes encoding proteins with synaptic function. Here, we present the first brain-focused characterization of a potential new susceptibility gene, ARHAGP8, which encodes a Rho GTPase activating protein (RhoGAP). Accumulating evidence suggests that ARHGAP8 plays a pivotal role in the pathogenesis of NPDs/NDDs. We provide the first evidence for ARHGAP8 as a novel player at excitatory synapses, with its synaptic localisation linked to the presence of the developmentally important NMDA receptor subunit GluN2B. By increasing ARHGAP8 levels in hippocampal neurons to mimic elevated levels found in subsets of patients, we observed reductions in dendritic complexity and spine volume, accompanied by a significant decrease in synaptic AMPA receptor-mediated transmission. These results suggest that ARHGAP8 plays a role in shaping the morphology and function of excitatory synapses, and prompt further investigation of ARHGAP8 as a candidate gene in NDDs/NPDs. ARHGAP8 is identified as an excitatory synaptic protein linked to neurodevelopmental disorders. Increased ARHGAP8 levels reduce dendritic complexity, spine size, and AMPA receptor-mediated signalling, highlighting a role in synapse function.
  • Protocol for performing 3D-STORM-based nanoscale organization of NMDA receptors in hippocampal brain tissue
    Joana S. Ferreira, Jeanne Linarès-Loyez, Pierre Bon, Laurent Cognet, Laurent Groc
    STAR Protocols, 2025
    Direct stochastic optical reconstruction microscopy (dSTORM) unveils ionotropic N-methyl-D-aspartate receptor (NMDAR) organization into discrete nanometer-size domains (nanoclusters) within the postsynaptic density (PSD) of glutamatergic synapses, tuning receptor signaling. Here, we present a protocol to perform 3D-dSTORM imaging of the NMDAR in organotypic and acute rat hippocampal brain slices by combining conventional dSTORM with fluorescent self-interference. We describe steps for sample preparation, immunohistochemistry, 3D-dSTORM acquisition, and image analysis to successfully super-resolve NMDAR nanodomains in three dimensions. For complete details on the use and execution of this protocol, please refer to Kellermayer et al., 1 Bon et al., 2 and Ferreira et al. 3 • Steps to prepare hippocampal brain slices for single-molecule imaging • Instructions for acute brain slice preparation from the rat brain after perfusion with PFA • Guidance on imaging settings to super-resolve NMDA receptor nanodomains in 2D and 3D • Analyze and compare the nanoscale organization of NMDA receptor subtypes in brain slices Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics. Direct stochastic optical reconstruction microscopy (dSTORM) unveils ionotropic N-methyl-D-aspartate receptor (NMDAR) organization into discrete nanometer-size domains (nanoclusters) within the postsynaptic density (PSD) of glutamatergic synapses, tuning receptor signaling. Here, we present a protocol to perform 3D-dSTORM imaging of the NMDAR in organotypic and acute rat hippocampal brain slices by combining conventional dSTORM with fluorescent self-interference. We describe steps for sample preparation, immunohistochemistry, 3D-dSTORM acquisition, and image analysis to successfully super-resolve NMDAR nanodomains in three dimensions.
  • Surface Glutamate Receptor Nanoscale Organization with Super-Resolution Microscopy (dSTORM)
    Joana Ferreira, Laurent Groc
    Neuromethods, 2024
  • GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development
    Inmaculada M. González-González, John A. Gray, Joana Ferreira, María Jose Conde-Dusman, Delphine Bouchet, Isabel Perez-Otaño, Laurent Groc
    Cell Reports, 2023
    Signaling via N-methyl-d-aspartate receptors (NMDARs) is critical for the maturation of glutamatergic synapses, partly through a developmental switch from immature synapses expressing primarily GluN2B- and GluN3A-containing subtypes to GluN2A-rich mature ones. This subunit switch is thought to underlie the synaptic stabilization of NMDARs necessary for neural network consolidation. However, the cellular mechanisms controlling the NMDAR exchange remain unclear. Using a combination of single-molecule and confocal imaging and biochemical and electrophysiological approaches, we show that surface GluN3A-NMDARs form a highly diffusive receptor pool that is loosely anchored to synapses. Remarkably, changes in GluN3A subunit expression selectively alter the surface diffusion and synaptic anchoring of GluN2A- but not GluN2B-NMDARs, possibly through altered interactions with cell surface receptors. The effects of GluN3A on NMDAR surface diffusion are restricted to an early time window of postnatal development in rodents, allowing GluN3A subunits to control the timing of NMDAR signaling maturation and neuronal network refinements.
  • Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses
    Chiara Paviolo, Joana S. Ferreira, Antony Lee, Daniel Hunter, Ivo Calaresu, Somen Nandi, Laurent Groc, Laurent Cognet
    Nano Letters, 2022
    We provide evidence of a local synaptic nano-environment in the brain extracellular space (ECS) lying within 500 nm of postsynaptic densities. To reveal this brain compartment, we developed a correlative imaging approach dedicated to thick brain tissue based on single-particle tracking of individual fluorescent single wall carbon nanotubes (SWCNTs) in living samples and on speckle-based HiLo microscopy of synaptic labels. We show that the extracellular space around synapses bears specific properties in terms of morphology at the nanoscale and inner diffusivity. We finally show that the ECS juxta-synaptic region changes its diffusion parameters in response to neuronal activity, indicating that this nano-environment might play a role in the regulation of brain activity.
  • Interplay between NMDA receptor dynamics and the synaptic proteasome
    Joana S. Ferreira, Blanka Kellermayer, Ana Luísa Carvalho, Laurent Groc
    European Journal of Neuroscience, 2021
    Proteasome activity at the excitatory synapse plays an important role in neuronal communication. The proteasome translocation to synapses is mediated by neuronal activity, in particular the activation of N‐methyl‐d‐aspartate receptors (NMDARs). These receptors are composed of different subunits with distinct trafficking properties that provide various signalling and plasticity features to the synapse. Yet whether the interplay between the proteasome and NMDAR relies on specific subunit properties remain unclear. Using a combination of single molecule and immunocytochemistry imaging approaches in rat hippocampal neurons, we unveil a specific interplay between GluN2B‐containing NMDARs (GluN2B‐NMDARs) and the synaptic proteasome. Sustained proteasome activation specifically increases GluN2B‐NMDAR (not GluN2A‐NMDAR) lateral diffusion. In addition, when GluN2B‐NMDAR expression is downregulated, the proteasome localization decreases at glutamatergic synapses. Collectively, our data fuel a model in which the cellular dynamics and location of GluN2B‐NMDARs and proteasome are intermingled, shedding new lights on the NMDAR‐dependent regulation of synaptic adaptation.
  • A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue
    Morgane Rosendale, Jessica Flores, Chiara Paviolo, Paolo Pagano, Jonathan Daniel, Joana Ferreira, Jean‐Baptiste Verlhac, Laurent Groc, Laurent Cognet, Mireille Blanchard‐Desce
    Advanced Materials, 2021
    Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular‐based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water‐soluble alternative, whose bottom‐up design allows for the fine‐tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size‐tunable, red‐emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked.
  • CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
    Tomohisa Hosokawa, Pin-Wu Liu, Qixu Cai, Joana S. Ferreira, Florian Levet, Corey Butler, Jean-Baptiste Sibarita, Daniel Choquet, Laurent Groc, Eric Hosy, Mingjie Zhang, Yasunori Hayashi
    Nature Neuroscience, 2021
  • Fluorescent sp3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses
    Amit Kumar Mandal, Xiaojian Wu, Joana S. Ferreira, Mijin Kim, Lyndsey R. Powell, Hyejin Kwon, Laurent Groc, YuHuang Wang, Laurent Cognet
    Scientific Reports, 2020
    Cellular and tissue imaging in the second near-infrared window (NIR-II, ~1000–1350 nm) is advantageous for in vivo studies because of low light extinction by biological constituents at these wavelengths. However, deep tissue imaging at the single molecule sensitivity has not been achieved in the NIR-II window due to lack of suitable bio-probes. Single-walled carbon nanotubes have emerged as promising near-infrared luminescent molecular bio-probes; yet, their inefficient photoluminescence (quantum yield ~1%) drives requirements for sizeable excitation doses (~1–10 kW/cm2) that are significantly blue-shifted from the NIR-II region (<850 nm) and may thus ultimately compromise live tissue. Here, we show that single nanotube imaging can be achieved in live brain tissue using ultralow excitation doses (~0.1 kW/cm2), an order of magnitude lower than those currently used. To accomplish this, we synthesized fluorescent sp3-defect tailored (6,5) carbon nanotubes which, when excited at their first order excitonic transition (~985 nm) fluoresce brightly at ~1160 nm. The biocompatibility of these functionalized nanotubes, which are wrapped by encapsulation agent (phospholipid-polyethylene glycol), is demonstrated using standard cytotoxicity assays. Single molecule photophysical studies of these biocompatible nanotubes allowed us to identify the optimal luminescence properties in the context of biological imaging.
  • Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites
    Joana S. Ferreira, Julien P. Dupuis, Blanka Kellermayer, Nathan Bénac, Constance Manso, Delphine Bouchet, Florian Levet, Corey Butler, Jean-Baptiste Sibarita, Laurent Groc
    Proceedings of the National Academy of Sciences of the United States of America, 2020
  • Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
    Chiara Paviolo, Federico N. Soria, Joana S. Ferreira, Antony Lee, Laurent Groc, Erwan Bezard, Laurent Cognet
    Methods, 2020
  • Correlative imaging of single carbon nanotubes and fluorescently labelled neuronal structures in the extracellular space of live brains
    Chiara Paviolo, Joana S. Ferreira, Antony Lee, Laurent Groc, Laurent Cognet
    Proceedings of SPIE the International Society for Optical Engineering, 2020
  • Self-interference (SELFI) microscopy for live super-resolution imaging and single particle tracking in 3D
    Jeanne Linarès-Loyez, Joana S. Ferreira, Olivier Rossier, Brahim Lounis, Gregory Giannone, Laurent Groc, Laurent Cognet, Pierre Bon
    Frontiers in Physics, 2019
  • Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses
    Blanka Kellermayer, Joana S. Ferreira, Julien Dupuis, Florian Levet, Dolors Grillo-Bosch, Lucie Bard, Jeanne Linarès-Loyez, Delphine Bouchet, Daniel Choquet, Dmitri A. Rusakov, Pierre Bon, Jean-Baptiste Sibarita, Laurent Cognet, Matthieu Sainlos, Ana Luisa Carvalho, Laurent Groc
    Neuron, 2018
  • Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
    Joana S Ferreira, Thomas Papouin, Laurent Ladépêche, Andrea Yao, Valentin C Langlais, Delphine Bouchet, Jérôme Dulong, Jean-Pierre Mothet, Silvia Sacchi, Loredano Pollegioni, Pierre Paoletti, Stéphane Henri Richard Oliet, Laurent Groc
    Elife, 2017
  • Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue
    Juan A. Varela, Joana S. Ferreira, Julien P. Dupuis, Pauline Durand, Delphine Bouchet, Laurent Groc
    Neurophotonics, 2016
  • Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia
    Marta M. Vieira, Jeannette Schmidt, Joana S. Ferreira, Kevin She, Shinichiro Oku, Miranda Mele, Armanda E. Santos, Carlos B. Duarte, Ann Marie Craig, Ana Luísa Carvalho
    Neurobiology of Disease, 2016
  • GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome
    Joana S. Ferreira, Jeannette Schmidt, Pedro Rio, Rodolfo Águas, Amanda Rooyakkers, Ka Wan Li, August B. Smit, Ann Marie Craig, Ana Luisa Carvalho
    Journal of Neuroscience, 2015
  • Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors
    Kevin She, Joana S. Ferreira, Ana Luisa Carvalho, Ann Marie Craig
    Journal of Biological Chemistry, 2012
  • Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors
    Sandra D. Santos, Olga Iuliano, Luís Ribeiro, Julien Veran, Joana S. Ferreira, Pedro Rio, Christophe Mulle, Carlos B. Duarte, Ana Luísa Carvalho
    Journal of Biological Chemistry, 2012
  • Activity and protein kinase C regulate synaptic accumulation of N-Methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant
    Joana S. Ferreira, Amanda Rooyakkers, Kevin She, Luis Ribeiro, Ana Luísa Carvalho, Ann Marie Craig
    Journal of Biological Chemistry, 2011
  • Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors
    André R. Gomes, Joana S. Ferreira, Ana V. Paternain, Juan Lerma, Carlos B. Duarte, Ana Luísa Carvalho
    Molecular and Cellular Neuroscience, 2008

RECENT SCHOLAR PUBLICATIONS

  • Neurexins, Ephrin receptors, and N-cadherin signaling as emerging mechanisms in synaptic dysfunction and neurodegenerative diseases
    J Gonçalves-Martins, C Cação, JS Ferreira
    Communications Biology , 2026
    2026
  • Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission
    J Schmidt, ÂS Inácio, J Ferreira, D Serrenho, R Socodato, N Beltrão, ...
    Communications Biology , 2026
    2026
    Citations: 2
  • Protocol for performing 3D-STORM-based nanoscale organization of NMDA receptors in hippocampal brain tissue
    JS Ferreira, J Linarès-Loyez, P Bon, L Cognet, L Groc
    STAR protocols 6 (1) , 2025
    2025
  • Type I TARPs regulate Kv7. 2 potassium channels and susceptibility to seizures
    MV Rodrigues, ÂS Inácio, MV Soldovieri, S Ribau, TM Leal, T Baurberg, ...
    bioRxiv, 2024.08. 09.607194 , 2024
    2024
  • Surface glutamate receptor nanoscale organization with super-resolution microscopy (dstorm)
    J Ferreira, L Groc
    New Technologies for Glutamate Interaction: Neurons and Glia, 35-52 , 2024
    2024
    Citations: 2
  • GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development
    IM Gonzalez-Gonzalez, JA Gray, J Ferreira, MJ Conde-Dusman, ...
    Cell reports 42 (5) , 2023
    2023
    Citations: 17
  • Near-infrared carbon nanotube tracking reveals the nanoscale extracellular space around synapses
    C Paviolo, JS Ferreira, A Lee, D Hunter, I Calaresu, S Nandi, L Groc, ...
    Nano Letters 22 (17), 6849-6856 , 2022
    2022
    Citations: 40
  • Interplay between NMDA receptor dynamics and the synaptic proteasome
    JS Ferreira, B Kellermayer, AL Carvalho, L Groc
    European Journal of Neuroscience 54 (6), 6000-6011 , 2021
    2021
    Citations: 18
  • CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
    T Hosokawa, PW Liu, Q Cai, JS Ferreira, F Levet, C Butler, JB Sibarita, ...
    Nature Neuroscience 24 (6), 777-785 , 2021
    2021
    Citations: 154
  • A Bottom‐Up Approach to Red‐Emitting Molecular‐Based Nanoparticles with Natural Stealth Properties and their Use for Single‐Particle Tracking Deep in Brain Tissue
    M Rosendale, J Flores, C Paviolo, P Pagano, J Daniel, J Ferreira, ...
    Advanced Materials 33 (22), 2006644 , 2021
    2021
    Citations: 25
  • What Can We Learn from Carbon Nanotube Diffusion Trajectories Recorded in the Live Brain?
    A Lee, N Danne, C Paviolo, F Soria, J Ferreira, E Bezard, L Groc, ...
    Electrochemical Society Meeting Abstracts 239, 527-527 , 2021
    2021
  • CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase
    T Hosokawa, PW Liu, Q Cai, JS Ferreira, F Levet, C Butler, JB Sibarita, ...
    bioRxiv, 2020.11. 25.397091 , 2020
    2020
    Citations: 1
  • Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites
    JS Ferreira, JP Dupuis, B Kellermayer, N Bénac, C Manso, D Bouchet, ...
    Proceedings of the National Academy of Sciences 117 (39), 24526-24533 , 2020
    2020
    Citations: 37
  • Correlative imaging of single carbon nanotubes and fluorescently labelled neuronal structures in the extracellular space of live brains
    C Paviolo, JS Ferreira, A Lee, L Groc, L Cognet
    Neurophotonics 11360, 49-56 , 2020
    2020
  • Fluorescent sp 3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses
    AK Mandal, X Wu, JS Ferreira, M Kim, LR Powell, H Kwon, L Groc, ...
    Scientific Reports 10 (1), 5286 , 2020
    2020
    Citations: 97
  • Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
    C Paviolo, FN Soria, JS Ferreira, A Lee, L Groc, E Bezard, L Cognet
    Methods 174, 91-99 , 2020
    2020
    Citations: 77
  • Self-interference (SELFI) microscopy for live super-resolution imaging and single particle tracking in 3D
    J Linarès-Loyez, JS Ferreira, O Rossier, B Lounis, G Giannone, L Groc, ...
    Frontiers in Physics 7, 68 , 2019
    2019
    Citations: 27
  • Differential nanoscale topography and functional role of GluN2-NMDA receptor subtypes at glutamatergic synapses
    B Kellermayer, JS Ferreira, J Dupuis, F Levet, D Grillo-Bosch, L Bard, ...
    Neuron 100 (1), 106-119. e7 , 2018
    2018
    Citations: 151
  • Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
    JS Ferreira, T Papouin, L Ladépêche, A Yao, VC Langlais, D Bouchet, ...
    Elife 6, e25492 , 2017
    2017
    Citations: 126
  • Single nanoparticle tracking of -methyl- d -aspartate receptors in cultured and intact brain tissue
    JA Varela, JS Ferreira, JP Dupuis, P Durand, D Bouchet, L Groc
    Neurophotonics 3 (4), 041808-041808 , 2016
    2016
    Citations: 26

MOST CITED SCHOLAR PUBLICATIONS

  • CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
    T Hosokawa, PW Liu, Q Cai, JS Ferreira, F Levet, C Butler, JB Sibarita, ...
    Nature Neuroscience 24 (6), 777-785 , 2021
    2021
    Citations: 154
  • Differential nanoscale topography and functional role of GluN2-NMDA receptor subtypes at glutamatergic synapses
    B Kellermayer, JS Ferreira, J Dupuis, F Levet, D Grillo-Bosch, L Bard, ...
    Neuron 100 (1), 106-119. e7 , 2018
    2018
    Citations: 151
  • Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
    JS Ferreira, T Papouin, L Ladépêche, A Yao, VC Langlais, D Bouchet, ...
    Elife 6, e25492 , 2017
    2017
    Citations: 126
  • Fluorescent sp 3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses
    AK Mandal, X Wu, JS Ferreira, M Kim, LR Powell, H Kwon, L Groc, ...
    Scientific Reports 10 (1), 5286 , 2020
    2020
    Citations: 97
  • Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
    C Paviolo, FN Soria, JS Ferreira, A Lee, L Groc, E Bezard, L Cognet
    Methods 174, 91-99 , 2020
    2020
    Citations: 77
  • GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome
    JS Ferreira, J Schmidt, P Rio, R Águas, A Rooyakkers, KW Li, AB Smit, ...
    Journal of Neuroscience 35 (22), 8462-8479 , 2015
    2015
    Citations: 77
  • Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia
    MM Vieira, J Schmidt, JS Ferreira, K She, S Oku, M Mele, AE Santos, ...
    Neurobiology of disease 89, 223-234 , 2016
    2016
    Citations: 56
  • Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors
    K She, JS Ferreira, AL Carvalho, AM Craig
    Journal of Biological Chemistry 287 (33), 27432-27445 , 2012
    2012
    Citations: 54
  • Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors
    SD Santos, O Iuliano, L Ribeiro, J Veran, JS Ferreira, P Rio, C Mulle, ...
    Journal of Biological Chemistry 287 (9), 6868-6877 , 2012
    2012
    Citations: 47
  • Near-infrared carbon nanotube tracking reveals the nanoscale extracellular space around synapses
    C Paviolo, JS Ferreira, A Lee, D Hunter, I Calaresu, S Nandi, L Groc, ...
    Nano Letters 22 (17), 6849-6856 , 2022
    2022
    Citations: 40
  • Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites
    JS Ferreira, JP Dupuis, B Kellermayer, N Bénac, C Manso, D Bouchet, ...
    Proceedings of the National Academy of Sciences 117 (39), 24526-24533 , 2020
    2020
    Citations: 37
  • Self-interference (SELFI) microscopy for live super-resolution imaging and single particle tracking in 3D
    J Linarès-Loyez, JS Ferreira, O Rossier, B Lounis, G Giannone, L Groc, ...
    Frontiers in Physics 7, 68 , 2019
    2019
    Citations: 27
  • Single nanoparticle tracking of -methyl- d -aspartate receptors in cultured and intact brain tissue
    JA Varela, JS Ferreira, JP Dupuis, P Durand, D Bouchet, L Groc
    Neurophotonics 3 (4), 041808-041808 , 2016
    2016
    Citations: 26
  • A Bottom‐Up Approach to Red‐Emitting Molecular‐Based Nanoparticles with Natural Stealth Properties and their Use for Single‐Particle Tracking Deep in Brain Tissue
    M Rosendale, J Flores, C Paviolo, P Pagano, J Daniel, J Ferreira, ...
    Advanced Materials 33 (22), 2006644 , 2021
    2021
    Citations: 25
  • Interplay between NMDA receptor dynamics and the synaptic proteasome
    JS Ferreira, B Kellermayer, AL Carvalho, L Groc
    European Journal of Neuroscience 54 (6), 6000-6011 , 2021
    2021
    Citations: 18
  • Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant
    JS Ferreira, A Rooyakkers, K She, L Ribeiro, AL Carvalho, AM Craig
    Journal of Biological Chemistry 286 (32), 28331-28342 , 2011
    2011
    Citations: 18
  • Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors
    AR Gomes, JS Ferreira, AV Paternain, J Lerma, CB Duarte, AL Carvalho
    Molecular and Cellular Neuroscience 37 (2), 323-334 , 2008
    2008
    Citations: 18
  • GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development
    IM Gonzalez-Gonzalez, JA Gray, J Ferreira, MJ Conde-Dusman, ...
    Cell reports 42 (5) , 2023
    2023
    Citations: 17
  • Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission
    J Schmidt, ÂS Inácio, J Ferreira, D Serrenho, R Socodato, N Beltrão, ...
    Communications Biology , 2026
    2026
    Citations: 2
  • Surface glutamate receptor nanoscale organization with super-resolution microscopy (dstorm)
    J Ferreira, L Groc
    New Technologies for Glutamate Interaction: Neurons and Glia, 35-52 , 2024
    2024
    Citations: 2