Palagan Senopati Sewoyo is lecturer at Faculty of Veterinary Medicine, Udayana University. He has a keen interest in veterinary pathology research. In addition to preclinical studies, he is also passionate about clinical medicine of companion animals and also pathology of avian and livestock animals. Any inquries about his research can be addressed at:
EDUCATION
Bachelor of Veterinary Medicine (BVM) (2017-2021)
Doctor of Veterinary Medicine (DVM) (2021-2023)
Master of Veterinary Science (MS) (2022-2024)
RESEARCH, TEACHING, or OTHER INTERESTS
Veterinary, Small Animals
15
Scopus Publications
117
Scholar Citations
7
Scholar h-index
3
Scholar i10-index
Scopus Publications
Intratumoral virotherapy with Indonesian Newcastle disease virus reduces mTOR expression and induces apoptosis in rat breast cancer models Ni Kadek Shita Amelia, I Nyoman Mantik Astawa, Ida Bagus Oka Winaya, I Ketut Berata, Ida Bagus Kade Suardana, et al. Journal of Advanced Veterinary Research, 2026 Autophagy and apoptosis are two key cellular pathways that are commonly promoted as therapeutic strategies for inhibiting cancer growth. Newcastle disease virus (NDV) has shown strong potency as cancer therapeutic agent and has been reported to induce both autophagy and apoptosis in malignant cells. NDV isolate from Indonesia has demonstrated oncolytic activity; however, the underlying mechanisms are not yet fully understood. Therefore, this study aimed to investigate the oncolytic mechanism of the Indonesian NDV isolate Tabanan-1/ARP/2017 by examining the expression of mTOR and caspase-3. Paraffin-embedded tissue blocks were obtained from a previous study. Six rats with breast cancer were divided into two groups: placebo group receiving 0.5 mL PBS, and therapy group receiving 7 log₂ HAU of NDV Tabanan-1/ARP/2017 per 0.5 mL administered intratumorally. Treatments were performed once daily for four consecutive days. After 15 days of initial treatment, the tumor tissues were collected, processed into paraffin blocks, and immunohistochemically stained with anti-mTOR and anti-caspase-3. The expression of both proteins was analyzed based on optical density using Fiji (ImageJ). mTOR expression in the therapy group was significantly lower than in the placebo group, whereas caspase-3 expression was significantly higher in the therapy group. These findings indicate that NDV Tabanan-1/ARP/2017 therapy is associated with decreased mTOR expression and apoptosis induction, as indicated by caspase-3 activation.
A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia Sewoyo Palagan Senopati, Nainggolan Willy Moris, Kardena I Made, Winaya Ida Bagus Oka, Gunawan I Wayan Nico Fajar, et al. Archives of Razi Institute, 2025 Urothelial carcinoma is a malignant neoplasm of the urinary tract arising from the transitional epithelium. Its clinical manifestations often overlap with non-neoplastic conditions, such as urinary tract infections, thereby presenting a diagnostic challenge for clinicians. Differentiating from others condition is important, as the treatment and prognoses vary significantly. This case report presented a 4-year-old female local dog, weighing 11.55 kg in BVC Animal Hospital with a primary complaint of hematuria. Clinical, hematological, and serum biochemical evaluations revealed no significant abnormalities. Ultrasonographic (USG) examination identified a hypoechoic mass measuring 0.31×0.85 cm located within the lumen and thickening of urinary bladder wall. Cytological assessment was performed via urine catheterization. The cytological specimen demonstrated a population of cells with anisocytosis, anisokaryosis, and a high nucleus-to-cytoplasm ratio, raising suspicion of a malignant tumor. Consequently, biopsy was performed via cystotomy to establish a definitive diagnosis. Prior to release the histopathological results, post-cystotomy the dog was treated with cefadroxil as antibiotics at 20 mg/kg BW b.i.d for 14 days, carprofen as anti-inflammatory at 2 mg/kg BW s.i.d. for 5 days, and tramadol as analgesics at 2 mg/kg BW b.i.d. for 5 days. Histopathological examination showed a non-encapsulated tumor with well-defined demarcation in the mucosa. The tumor consists of a dense population of epithelial tumor cells without evidence of invasion, confirmed the diagnosis of non-invasive, non-papillary urothelial carcinoma (in situ). The patient was managed palliatively with the administration of piroxicam at 0.3 mg/kg BW s.i.d as monotherapy. Until day 190, the dog showing a stable disease. To the best of the authors' knowledge, this is the first documented case of canine urothelial carcinoma in Indonesi.
Canine acanthomatous ameloblastoma in a golden retriever mix dog Journal of Advanced Veterinary Research, 2025
Surgical management of severe tail injury by partial caudectomy in a long-tailed macaque (Macaca fascicularis) Journal of Advanced Veterinary Research, 2025
Zoonotic Hepatitis E Virus: Epidemiology, Animal Reservoirs, and Control Strategies , I Made Kardena, Palagan Senopati Sewoyo, , Anak Agung Gde Oka Dharmayudha, , Wayan Nico Fajar Gunawan, , Putu Devi Jayanti, , Nyoman Mantik Astawa, , Anak Agung Ayu Mirah Adi, , I Nyoman Suarsana, , I Nyoman Suartha, , Alan P. Dargantes, and World S Veterinary Journal, 2025 Hepatitis E virus (HEV) is a leading cause of acute hepatitis transmitted through the enteric route, impacting millions of individuals worldwide annually. While HEV is generally self-limiting, it can lead to considerable illness and death, particularly in gestating women, immunocompromised individuals, and those with pre-existing conditions, such as chronic liver disease. Hepatitis E virus genotypes 1 and 2 infect solely humans and are prevalent in areas with poor sanitation, whereas genotypes 3 and 4 are zoonotic, infecting both animals and humans. Hepatitis E virus genotype 7 has been reported to infect both humans and animals; however, further research is needed to clarify its zoonotic potential. Zoonotic transmission occurs primarily through the consumption of contaminated meat and close contact with infected animals, posing significant public health risks. Epidemiological studies indicated an increasing seroprevalence of HEV in humans and animals across diverse regions, highlighting the need for strengthened public health measures. While HEV infections in animal reservoirs are generally asymptomatic, they represent a critical source of human infections. The present review aimed to highlight HEV's current classification, epidemiology, modes of transmission from animals to humans, prevention, and control measures, with a special focus on HEV zoonotic genotypes and their animal reservoirs.
Sebaceous Adenoma in a Geriatric Poodle Dog: A Case Report Ida Bagus Oka Winaya, Anak Agung Ayu Mirah Adi, Luh Made Sudimartini, I Made Merdana, Putu Henrywaesa Sudipa, I Gusti Agung Gde Putra Pemayun, Palagan Senopati Sewoyo Jurnal Medik Veteriner, 2024 A 14-year-old black male Poodle was brought to the Animal Teaching Hospital, Udayana University by its owner with clinical signs of frequent licking of its left front paw. Upon examination, red bumps were observed on the left front leg, accompanied by small, round black spots scattered on the dorsal side of the body. Additionally, black nodules were present on the lower eyelids and hind limbs. Surgical intervention was undertaken to excise the tumor mass, with the animal under anesthesia induced by ketamine at 5 mg/kg BW intravenously. The reddish nodule was excised by performing an elliptical incision at the base of tumor. Postoperatively, the animal received an antibacterial injection comprising ceftriaxone and tazobactam at 25 mg/kg BW intramuscularly and antiseptic wound dressing for supportive care. Microscopic examination revealed neoplastic cells arranged into lobules of varying sizes and shapes within the tumor mass. These lobules consisted of differentiated sebocytes and basaloid cells. At the periphery of the neoplastic lobules, the basaloid cells displayed several layers and exhibited invasion with moderate anisocytosis. The mitotic index was no more than ten cells in one field of view. Based on these histopathological features, the tumor was confirmed to be a sebaceous adenoma. After a 10-month follow-up period, there were no signs of tumor recurrence observed.
Newcastle disease virus Tabanan-1/ARP/2017 inhibits growth of rat mammary carcinoma models Journal of Advanced Veterinary Research, 2024
Establishment of Mammary Tumors by Injection of 7,12-Dimethylbenz[a]anthracene in Mammary Fat Pad of Rats Palagan Senopati Sewoyo, Ni Luh Lasmi Purwanti, Muhammad Munawaroh, I Made Kardena, I Nyoman Mantik Astawa World S Veterinary Journal, 2024 Chemical-induced mammary cancer models are widely used to mimic human breast carcinogenesis, with 7,12-dimethylbenz[a]anthracene (DMBA) being a commonly used agent. The oral administration of DMBA frequently results in the formation of tumors at random locations and carries significant risks, including high mortality rates and damage to various organs. To address these issues, this study employed a subcutaneous DMBA administration protocol to induce mammary cancer in rats. A total of twenty-four female Sprague-Dawley rats aged 45-55 days weighing 112-130 g were divided into four groups, including the control group injected with 0.75 mL corn oil (D0), a single dose of DMBA at 80 mg/kg BW (D1), two doses with a one-week interval (D2), and three doses with one-week intervals (D3), all administered via subcutaneous in mammary fat pad. Control groups (D0) did not show any tumor growth. Mammary tumor incidence increased with dosage (D1 33.33%, D2 66.67%, and D3 100%). Histopathological examination revealed the presence of various mammary tumor types without evidence of metastasis in all induced rats. All tumors originated from the injection site, and only a single nodule was observed in each rat. There were no significant differences in tumor grades between the treatment groups, and no mortality was recorded during the study. The D3 group showed the highest tumor incidence over the three-month observation period. These findings suggest that subcutaneous DMBA administration effectively induces mammary cancer in rat models with controlled tumor localization and minimal systemic effects, making it a promising method for experimental breast cancer studies.
Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study Palagan Senopati Sewoyo, Anak Agung Ayu Mirah Adi, Ida Bagus Oka Winaya, I Wayan Wirata Jurnal Medik Veteriner, 2023 A particular type of tumor that is frequently detected in female dogs who are sexually active is a mammary tumor. Neoplasia results from DNA-based alterations in cell cycle regulating genes. The mammary gland is prone to the formation of tumors due to its dynamic structure. The development of this tumor is supported by numerous variables. It has been recently discovered that there is substantial evidence linking the BRCA2 gene to the process of cancer. Standard examination techniques, such as fine needle aspiration, histopathology, and immunohistochemistry, are used along with ancillary tests to determine the tumor type and degree of malignancy. The primary treatment option for malignant tumors is surgical resection followed by adjuvant chemotherapy; benign tumors necessitate surgical resection as well. Adjuvant therapy options include hormone therapy and non-steroidal anti-inflammatory medications. Tumor tissue undergoes angiogenesis as it grows and develops to accommodate the abundant supply of nutrients. Therefore, angiogenesis-inhibiting therapies can be utilized to halt the growth of tumor cells. A number of antiangiogenic medications are now being studied in clinical settings on humans, and several more are undergoing trials on animals. In addition to pharmaceuticals, viruses may be used as a therapeutic to block tumor angiogenesis.
Isolation of Newcastle Disease Virus Genotype VII from Native Chicken in Republic Democratic of Timor-Leste Journal of Advanced Veterinary Research, 2022
Canine Transmissible Venereal Tumor: Treatment Review and Updates Revista Electronica De Veterinaria, 2022
Haematological Profile of Rat Fibrosarcoma Models after Virulent Newcastle Disease Virus Virotherapy: A Pilot Study Revista Electronica De Veterinaria, 2022
In Vivo Oncolytic Potency of Newcastle Disease Virus Gianyar-1/AK/2014 Virulent Strain against Mice Fibrosarcoma Models Revista Electronica De Veterinaria, 2022
The Potency of Virulent Newcastle Disease Virus Tabanan-1/ARP/2017 as Virotherapy Agents in Rat Fibrosarcoma Models Journal of Advanced Veterinary Research, 2021
RECENT SCHOLAR PUBLICATIONS
Parasit Darah pada Anjing: Aspek Parasitologi, Imunopatologi, dan Manajemen Klinis IPCP Putra, AA Yansri, FM Pancar, SL Adrenalin, A Wicaksono, ... 2026
Intratumoral virotherapy with Indonesian Newcastle disease virus reduces mTOR expression and induces apoptosis in rat breast cancer models NKS Amelia, INM Astawa, IBO Winaya, IK Berata, IBK Suardana, ... Journal of Advanced Veterinary Research 16 (3), 347-350 , 2026 2026
Kupas Tuntas Coccidiosis: Tantangan Global pada Industri Perunggasan IPC Putra, NLP Septianingsih, Suriansyah, JDM Yasa, PS Sewoyo, ... 2026
Indonesian Newcastle Disease Virus Induces Apoptosis and Suppresses Angiogenesis in Rat Mammary Carcinoma Models PS Sewoyo 10th International Congress on Veterinary and Animal Sciences (ICVAS), 156 , 2026 2026
Seroprevalence, potential risk factors, and pathological observation of classical swine fever in pigs in Bali Province, Indonesia IM Kardena, PS Sewoyo, IBO Winaya, IBW Adnyana, IK Berata, ... Japanese Journal of Veterinary Research 73 (3-4), 72-82 , 2025 2025
Surgical Removal of Air Rifle Projectile in Long-Tailed Macaques (Macaca fascicularis) in the Ubud Monkey Forest PS Sewoyo, IW Wirata, IW Gorda, AAG Jayawardhita, IW Bebas, IG Soma, ... Journal of Applied Veterinary Science and Technology 6 (2), 158-162 , 2025 2025
Tingkat Pengetahuan dan Risiko Praktis Pemeliharaan Babi terhadap Penyakit Japanese Encephalitis pada Peternak di Denpasar dan Badung, Provinsi Bali IM Kardena, PS Sewoyo, IN Suarsana, NLP Suariyani, M Bruce Seminar Nasional dan Workshop Veteriner III Fakultas Kedokteran Hewan … , 2025 2025
Vaksin Inaktif Rabies Mempertahankan Fungsi Biologisnya Pasca Penyimpanan pada Suhu 37°C selama 2 Jam TK Sari, PS Sewoyo, IGAAS Suartini Seminar Nasional dan Workshop Veteriner III Fakultas Kedokteran Hewan … , 2025 2025
Isolat Virus Newcastle Disease Asal Bali Memicu Apoptosis dan Menekan Angiogenesis pada Tikus Model Karsinoma Mammae PS Sewoyo, INM Astawa, TK Sari, IM Kardena, IBO Winaya, IK Berata Seminar Nasional dan Workshop Veteriner III Fakultas Kedokteran Hewan … , 2025 2025
Penyakit Parasit pada Unggas IPC Putra, AA Yansri, A Ris, KF Rinca, NLPD Septianingsih, ... 2025
Patogenesis dan Perubahan Patologi Infeksi Parasit pada Unggas PS Sewoyo Penyakit Parasit pada Unggas, 243-268 , 2025 2025
The Role of p53 as the Guardian of the Genome and the Consequences of Its Mutation in Cancer Development: A Review MS Purwitasari, PS Sewoyo, INM Astawa Jurnal Medika Veterinaria 19 (2), 74-87 , 2025 2025
Pathology of Concurrent Infection of Metastrongylus apri with Trichuris suis in a Yorkshire Pig PS Sewoyo, R Permana, IPC Putra, P Suandhika International Journal of Veterinary and Animals Research 8 (2), 49-53 , 2025 2025
A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia PS Sewoyo, WM Nainggolan, IM Kardena, IBO Winaya, IWNF Gunawan, ... Archives of Razi Institute 80 (5), 1345-1351 , 2025 2025
Surgical management of severe tail injury by partial caudectomy in a long-tailed macaque (Macaca fascicularis) PS Sewoyo, IW Wirata, IW Gorda, AAG Jayawardhita, IG Soma, ... Journal of Advanced Veterinary Research 15 (3), 394-396 , 2025 2025 Citations: 1
Canine acanthomatous ameloblastoma in a golden retriever dog C Yudeska, PS Sewoyo Journal of Advanced Veterinary Research 15 (3), 390-393 , 2025 2025
Zoonotic Hepatitis E Virus: Epidemiology, Animal Reservoirs, and Control Strategies IM Kardena, PS Sewoyo, AAGO Dharmayudha, IW Nico, F Gunawan, ... World's Veterinary Journal 15 (1), 182-193 , 2025 2025
Clinicopathology of Domestic Pigeon Infected with Haemoproteus columbae: A Case Report P Suandhika, EH Habibah, PS Sewoyo Indonesia Medicus Veterinus 14 (1), 54-62 , 2025 2025
Indonesian Newcastle Disease Virus Field Isolate Reduces c-Jun Expression in Rat Mammary Cancer Models FGS Marson, PS Sewoyo, INM Astawa, AAAM Adi, IBK Suardana, ... Media Kedokteran Hewan 36 (1), 13-20 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
The Potency of Virulent Newcastle Disease Virus Tabanan-1/ARP/2017 as Virotherapy Agents in Rat Fibrosarcoma Models PS Sewoyo, AAAM Adi, IBO Winaya, IP Sampurna, AAB Bramardipa Journal of Advanced Veterinary Research 11 (2), 64-68 , 2021 2021 Citations: 20
Canine transmissible venereal tumor: treatment review and updates PS Sewoyo, IM Kardena REDVET-Revista electrónica de Veterinaria 23 (1), 2022 , 2022 2022 Citations: 17
Treatment of transmissible venereal tumor without metastasis in mixed local Balinese dog by surgery and vincristine sulfate: A case report DN Takariyanti, IW Gorda, PS Sewoyo International Journal of Veterinary Sciences and Animal Husbandry 6 (3), 25-29 , 2021 2021 Citations: 12
Haematological Profile of Rat Fibrosarcoma Models After Virulent Newcastle Disease Virus Virotherapy: A Pilot Study PS Sewoyo, AAAM Adi, NLE Setiasih, IGAMA Dewi Revista electrónica de Veterinaria, 47-55 , 2022 2022 Citations: 8
In Vivo Oncolytic Potency of Newcastle Disease Virus Gianyar-1/AK/2014 Virulent Strain against Mice Fibrosarcoma Models I Rakhmawati, AAAM Adi, IBO Winaya, PS Sewoyo Revista electrónica de Veterinaria, 56-63 , 2022 2022 Citations: 8
Profil Bobot Badan dan Tingkat Mortalitas Tikus Jantan Galur Sprague Dawley Selama Pembentukan Fibrosarkoma yang Dipicu oleh Benzo(a)piren PS Sewoyo, AAAM Adi, IBO Winaya Indonesia Medicus Veterinus 10 (1), 1-11 , 2021 2021 Citations: 8
Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study PS Sewoyo, AAAM Adi, IBO Winaya, IW Wirata Jurnal Medik Veteriner 6 (2), 271-287 , 2023 2023 Citations: 7
Laporan Kasus: Klinikopatologi Anak Anjing yang Mengalami Enteritis dan Miokarditis Akibat Infeksi Canine Parvovirus PS Sewoyo, IBO Winaya, IK Berata, AAAM Adi, MD Dayanti, R Grahadi, ... Buletin Veteriner Udayana 14 (6), 693-704 , 2022 2022 Citations: 5
Newcastle disease virus Tabanan-1/ARP/2017 inhibits growth of rat mammary carcinoma models PS Sewoyo, INM Astawa, AAAM Adi, MS Purwitasari, INST Hartaputera, ... Journal of Advanced Veterinary Research 14 (4), 563-566 , 2024 2024 Citations: 4
Laporan Kasus: Keberhasilan Penanganan Rinitis Unilateral Kronis yang Menyebabkan Polisitemia Sekunder pada Kucing Lokal PS Sewoyo, SK Widyastuti, IGMK Erawan Indonesia Medicus Veterinus 11 (6), 898-911 , 2022 2022 Citations: 4
Sebaceous Adenoma Case in a Golden Retriever Dog PS Sewoyo, WM Nainggolan Journal of Applied Veterinary Science and Technology 6 (2), 122-126 , 2023 2023 Citations: 3
Pathology of proventricular tetrameriasis in a free-range chicken PS Sewoyo, IPC Putra, WM Nainggolan ARSHI Veterinary Letters 8 (3), 47-48 , 2024 2024 Citations: 2
Case Report: Anatomic Pathology of Bali Cattle Liver Infested with Fasciola gigantica PS Sewoyo, NLL Purwanti, S Evan Media Kedokteran Hewan 35 (1), 28-35 , 2024 2024 Citations: 2
Incisional Hernia Case Management in a Local Cat PS Sewoyo, MS Purwitasari, P Rabiulfa, IW Wirata Journal of Applied Veterinary Science and Technology 4 (2), 115-121 , 2023 2023 Citations: 2
Laporan Kasus: Ascites Disertai Distensi Vena Abdominalis Akibat Gangguan Fungsi Hati pada Anjing PY Cahyanti, SK Widyastuti, PD Jayanti, PS Sewoyo, R Permana Indonesia Medicus Veterinus 12 (2), 223-232 , 2023 2023 Citations: 2
Surgical management of severe tail injury by partial caudectomy in a long-tailed macaque (Macaca fascicularis) PS Sewoyo, IW Wirata, IW Gorda, AAG Jayawardhita, IG Soma, ... Journal of Advanced Veterinary Research 15 (3), 394-396 , 2025 2025 Citations: 1
Establishment of Mammary Tumors by Injection of 7,12-Dimethylbenz[a]anthracene in Mammary Fat Pad of Rats PS Sewoyo, NLL Purwanti, M Munawaroh, IM Kardena, INM Astawa World's Veterinary Journal 14 (4), 490-497 , 2024 2024 Citations: 1
