Peritoneal Implants and Drug Delivery Muhammad Ali Syed, Muhammad Irfan, Ameer Fawad Zahoor, Haroon Khalid Syed, Shahid Shah, Muhammad Ajmal Shah, Nayyer Islam, Sana Hanif Exploring Drug Delivery to the Peritoneum, 2024
Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability enhancement; in vitro and in vivo assessment Nayyer Islam, Naveed Ullah Khan, Anam Razzaq, Zaheer Ullah Khan, Farid Menaa, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Haroon Iqbal, Jiang Ni Saudi Pharmaceutical Journal, 2023 Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy is limited by low solubility and oral bioavailability. The current research work attempted to augment the oral bioavailability of ITZ by incorporating into self-emulsifying micelles (SEMCs). To fabricate the SEMCs, various preparation techniques including physical mixture, melt-emulsification, solvent evaporation and kneading, were opted by using different weight ratio of drug and solubilizers i.e. Gelucire-50/13 or Gelucire-44/14 and characterized both in vitro and in vivo. The prepared SEMCs were found to be in the size range from 63.4 ± 5.2 to 284.2 ± 19.5 nm with surface charges ranging from -16 ± 1.2 to -27 ± 2.0 mV. The drug solubility was improved to a reasonable extent with all investigated formulations, however, SEMCs in group 6 prepared by kneading method (KMG6) using Gelucire-44/14: drug (10:1 presented 87.6 folds’ increase (964.93 ± 2 μg/mL) compared to solubility of crystalline ITZ (11 ± 2 μg/mL) through kneading method. In addition, KMG6 SEMCs shows the fast drug release compared to other SEMCs. Further, KMG6 SEMCs also exhibited 5.12-fold higher relative intestinal serosal fluid absorption compared to crystalline ITZ. The pharmacokinetic parameters such Cmax, AUC and Tmax of KMG6 SEMCs significantly improved compared to crystalline ITZ. In conclusion, the manipulation of ITZ solubility, dissolution rate and absorption using SEMCs is a promising strategy for bioavailability enhancement.
Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen Muhammad Usman Munir, Mahnoor Ikraam, Muhammad Nadeem, Syed Haroon Khalid, Sajid Asghar, Ikrima Khalid, Muhammad Irfan, Nayyer Islam, Nyla Ajaz, Ikram Ullah Khan Pharmaceuticals, 2022 The aim of this study was to improve the solubility and prevent the ulcerogenic effect of flurbiprofen. Initially, binary and ternary solid dispersions (BSDs and TSDs) of flurbiprofen were prepared by using non-ordered mesoporous silica and gelucire. After preformulation testing (solubility, flow properties, % yield, and entrapment efficiency), four formulations were selected for further detailed studies. Solid-state characterization of optimized formulations (S1, S6, S7, and S12) showed successful drug incorporation in the solid dispersion at the molecular state without any noticeable interactions. The in vitro solubility and release study showed an increase in solubility and 98–100% of drug release in 30–45 min. The in vivo gastro-protective effect of the optimized formulations containing flurbiprofen and silica (1:1) with 25% w/w gelucire (S6 and S12) showed a reduction in the gastric lesion index (GLI) after four days of treatment. Moreover, histological images of the stomach lining (S6 and S12) illustrated normal epithelial cells and a partially protected mucosal membrane. Thus, TSD exhibited a significant increase in solubility and the dissolution rate and reduced the gastric ulceration. Therefore, TSDs are dubbed as efficacious carriers to enhance the bioavailability of flurbiprofen while simultaneously reducing its side effects.
Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections Iman Fatima, Akhtar Rasul, Shahid Shah, Malik Saadullah, Nayyer Islam, Ahmed Khames, Ahmad Salawi, Muhammad Masood Ahmed, Yosif Almoshari, Ghulam Abbas, Mohammed A. S. Abourehab, Sajid Mehmood Khan, Zunera Chauhdary, Meshal Alshamrani, Nader Ibrahim Namazi, Demiana M. Naguib Molecules, 2022 The occurrence of fungal infections has increased over the past two decades. It is observed that superficial fungal infections are treated by conventional dosage forms, which are incapable of treating deep infections due to the barrier activity possessed by the stratum corneum of the skin. This is why the need for a topical preparation with advanced penetration techniques has arisen. This research aimed to encapsulate fluconazole (FLZ) in a novasome in order to improve the topical delivery. The novasomes were prepared using the ethanol injection technique and characterized for percent entrapment efficiency (EE), particle size (PS), zeta potential (ZP), drug release, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and antifungal activity. The FN7 formulation with 94.45% EE, 110 nm PS and −24 ZP proved to be the best formulation. The FN7 formulation showed a 96% release of FLZ in 8 h. FTIR showed the compatibility of FLZ with excipients and DSC studies confirmed the thermal stability of FLZ in the developed formulation. The FN7 formulation showed superior inhibition of the growth of Candida albicans compared to the FLZ suspension using a resazurin reduction assay, suggesting high efficacy in inhibiting fungal growth.
Solubility and Dissolution Enhancement of Dexibuprofen with Hydroxypropylbetacyclodextrin (HPβCD) and Poloxamers (188/407) Inclusion Complexes: Preparation and In Vitro Characterization Rabia Munir, Abdul Hadi, Salah-ud-Din Khan, Sajid Asghar, Muhammad Irfan, Ikram Ullah Khan, Misbah Hameed, Sana Inam, Nayyer Islam, Shahzadi Filza Hassan, Memoona Ishtiaq, Pervaiz Akhtar Shah, Muhammad Shahid Iqbal, Haroon Khalid Syed, Ahmed Khames, Mohammad A. S. Abourehab Polymers, 2022 The objective of this study was to improve the dissolution and solubility of dexibuprofen (DEX) using hydroxypropyl beta cyclodextrin (HPβCD) inclusion complexes and also to evaluate the effect of presence of hydrophilic polymers on solubilization efficiency of HPβCD. Three different methods (physical trituration, kneading and solvent evaporation) were used to prepare binary inclusion complexes at various drug-to-cyclodextrin weight ratios. An increase in solubility and drug release was observed with the kneading (KN) method at a DEX/HPβCD (1:4) weight ratio. The addition of hydrophilic polymers poloxamer-188 (PXM-188) and poloxamer-407 (PXM-407) at 2.5, 5.0, 10.0 and 20% w/w enhanced the complexation efficiency and solubility of DEX/HPβCD significantly. Fourier-transform infrared (FTIR) analysis revealed that DEX was successfully incorporated into the cyclodextrin cavity. Differential scanning calorimetry (DSC) and X-ray diffractometry (XRD) revealed less crystallinity of the drug and its entrapment in the cyclodextrin molecular cage. The addition of PXM-188 or PXM-407 reduced the strength of the DEX endothermic peak. With the addition of hydrophilic polymers, sharp and intense peaks of DEX disappeared. Finally, it was concluded that PXM-188 at a weight ratio of 10.0% w/w was the best candidate for improving solubility, stability and release rate of DEX.
Rising XDR-Typhoid Fever Cases in Pakistan: Are We Heading Back to the Pre-antibiotic Era? Muhammad Hammad Butt, Aqsa Saleem, Syed Owais Javed, Irfan Ullah, Mujeeb Ur Rehman, Nayyer Islam, Muhammad Azam Tahir, Tangina Malik, Sara Hafeez, Shahzadi Misbah Frontiers in Public Health, 2022 1 Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan, Dow University of Health Sciences, Karachi, Pakistan, 3 Kabir Medical College, Gandhara University, Peshawar, Pakistan, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan, 5 Khaldunia college of Pharmacy, Lahore, Pakistan, University of the Punjab, Lahore, Pakistan, Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan
Effect of Polar Protic Solvents on the Physicochemical Properties and Dissolution of Soluplus Based Solid Dispersions of Rosuvastatin Calcium Latin American Journal of Pharmacy, 2022
In vitro-Ex vivo Characterization of Agarose – Carbopol 934® Based Buccal Mucoadhesive Tablets Containing Benzocaine and Tibezonium Iodide as Model Drugs Latin American Journal of Pharmacy, 2022
Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin Latin American Journal of Pharmacy, 2022
Improved bioavailability of ebastine through development of transfersomal oral films Nayyer Islam, Muhammad Irfan, Ameer Fawad Zahoor, Muhammad Shahid Iqbal, Haroon Khalid Syed, Ikram Ullah Khan, Akhtar Rasul, Salah-Ud-Din Khan, Alaa M. Alqahtani, Muzzamil Ikram, Muhammad Abdul Qayyum, Ahmed Khames, Sana Inam, Mohammed A. S. Abourehab Pharmaceutics, 2021
Evaluation of solubility and dissolution of lamotrigine using lipid based microparticulate carriers: An in-vitro analysis Pakistan Journal of Pharmaceutical Sciences, 2020
RECENT SCHOLAR PUBLICATIONS
Improved solubility and stability of aripiprazole in binary and ternary inclusion complexes using methyl-β-cyclodextrin and L-arginine S Awais, K Sultana, MT Ansari, N Islam, M Afridi Pak. J. Pharm. Sci 35 (5), 1415-1422 , 2022 2022 Citations: 3
Fabrication, in vitro and in vivo evaluation of non-ordered mesoporous silica-based ternary solid dispersions for enhanced solubility of flurbiprofen MU Munir, M Ikraam, M Nadeem, SH Khalid, S Asghar, I Khalid, M Irfan, ... Pharmaceuticals 15 (7), 856 , 2022 2022 Citations: 11
Novasomes as nano-vesicular carriers to enhance topical delivery of fluconazole: a new approach to treat fungal infections I Fatima, A Rasul, S Shah, M Saadullah, N Islam, A Khames, A Salawi, ... Molecules 27 (9), 2936 , 2022 2022 Citations: 52
Piperine phytosomes for bioavailability enhancement of domperidone N Islam, M Irfan, T Hussain, M Mushtaq, IU Khan, AM Yousaf, MU Ghori, ... Journal of Liposome Research 32 (2), 172-180 , 2022 2022 Citations: 56
Solubility and dissolution enhancement of dexibuprofen with hydroxypropylbetacyclodextrin (HPβCD) and poloxamers (188/407) inclusion complexes: preparation and in vitro … R Munir, A Hadi, SD Khan, S Asghar, M Irfan, IU Khan, M Hameed, S Inam, ... Polymers 14 (3), 579 , 2022 2022 Citations: 34
Rising XDR-typhoid fever cases in Pakistan: are we heading back to the pre-antibiotic era? MH Butt, A Saleem, SO Javed, I Ullah, MU Rehman, N Islam, MA Tahir, ... Frontiers in public health 9, 794868 , 2022 2022 Citations: 82
Synthesis and characterization of self-assembling chitosan-based nanoparticles. J Qureshi, FM Iqbal, Z Danish, SNH Shah, H Umar, M Zaman, MN Alvi, ... Pakistan Journal of Pharmaceutical Sciences 35 , 2022 2022 Citations: 1
Solubility and dissolution enhancement of dexibuprofen by inclusion complexation with cyclodextrin R Munir, U Mashood, S Asgher, IU Khan, M Irfan, S Inam, N Islam, N Ajaz, ... Lat. Am. J. Pharm 41 (1), 235-43 , 2022 2022 Citations: 5
Effect of Polar Protic Solvents on the Physicochemical Properties and Dissolution of Soluplus Based Solid Dispersions of Rosuvastatin Calcium S Inam, M Irfan, MS Iqbal, HK Syed, N Islam Latin American Journal of Pharmacy 41 (2), 455-462 , 2022 2022
In vitro-ex vivo characterization of agarose—carbopol 934® based buccal mucoadhesive tablets containing benzocaine and tibezonium iodide as model drugs A Muhammad, AF Zahoor, MS Iqbal, K Haroon, IU Khan, MA Shah, ... Lat. Am. J. Pharm 41 (5), 1-10 , 2022 2022 Citations: 9
Improved bioavailability of ebastine through development of transfersomal oral films N Islam, M Irfan, AF Zahoor, MS Iqbal, HK Syed, IU Khan, A Rasul, ... Pharmaceutics 13 (8), 1315 , 2021 2021 Citations: 38
Poloxamer-188 and d -α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral … N Islam, M Irfan, SUD Khan, HK Syed, MS Iqbal, IU Khan, A Mahdy, ... Pharmaceutics 13 (1), 54 , 2021 2021 Citations: 32
Improved Bioavailability of Ebastine through Development of Transfersomal Oral Films. Pharmaceutics 2021, 13, 1315 N Islam, M Irfan, AF Zahoor, MS Iqbal, HK Syed, IU Khan, A Rasul, ... s Note: MDPI stays neutral with regard to jurisdictional claims in published … , 2021 2021 Citations: 2
Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits MU Rehman, A Rasul, MI Khan, M Rasool, G Abbas, F Masood, I Nazir, ... Pak. J. Pharm. Sci 34 (1), 313-319 , 2021 2021 Citations: 7
Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/bile salt bilosomes. N Islam, AF Zahoor, HK Syed, MS Iqbal, IU Khan, G Abbas, M Mushtaq, ... Pakistan Journal of Pharmaceutical Sciences 33 , 2020 2020 Citations: 15
Enhancement of solubility and dissolution rate of ebastine fast-disintegrating tablets by solid dispersion method. N Islam, M Irfan, N Abbas, HK Syed, MS Iqbal, A Rasul, S Inam, A Hussain, ... Tropical Journal of Pharmaceutical Research 19 (9) , 2020 2020 Citations: 6
Evaluation of solubility and dissolution of lamotrigine using lipid based microparticulate carriers: An in-vitro analysis. N Islam, M Irfan, AF Zahoor, HK Syed, IU Khan, MS Iqbal, A Rasul, ... Pakistan Journal of Pharmaceutical Sciences 33 , 2020 2020 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Rising XDR-typhoid fever cases in Pakistan: are we heading back to the pre-antibiotic era? MH Butt, A Saleem, SO Javed, I Ullah, MU Rehman, N Islam, MA Tahir, ... Frontiers in public health 9, 794868 , 2022 2022 Citations: 82
Piperine phytosomes for bioavailability enhancement of domperidone N Islam, M Irfan, T Hussain, M Mushtaq, IU Khan, AM Yousaf, MU Ghori, ... Journal of Liposome Research 32 (2), 172-180 , 2022 2022 Citations: 56
Novasomes as nano-vesicular carriers to enhance topical delivery of fluconazole: a new approach to treat fungal infections I Fatima, A Rasul, S Shah, M Saadullah, N Islam, A Khames, A Salawi, ... Molecules 27 (9), 2936 , 2022 2022 Citations: 52
Improved bioavailability of ebastine through development of transfersomal oral films N Islam, M Irfan, AF Zahoor, MS Iqbal, HK Syed, IU Khan, A Rasul, ... Pharmaceutics 13 (8), 1315 , 2021 2021 Citations: 38
Solubility and dissolution enhancement of dexibuprofen with hydroxypropylbetacyclodextrin (HPβCD) and poloxamers (188/407) inclusion complexes: preparation and in vitro … R Munir, A Hadi, SD Khan, S Asghar, M Irfan, IU Khan, M Hameed, S Inam, ... Polymers 14 (3), 579 , 2022 2022 Citations: 34
Poloxamer-188 and d -α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral … N Islam, M Irfan, SUD Khan, HK Syed, MS Iqbal, IU Khan, A Mahdy, ... Pharmaceutics 13 (1), 54 , 2021 2021 Citations: 32
Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/bile salt bilosomes. N Islam, AF Zahoor, HK Syed, MS Iqbal, IU Khan, G Abbas, M Mushtaq, ... Pakistan Journal of Pharmaceutical Sciences 33 , 2020 2020 Citations: 15
Fabrication, in vitro and in vivo evaluation of non-ordered mesoporous silica-based ternary solid dispersions for enhanced solubility of flurbiprofen MU Munir, M Ikraam, M Nadeem, SH Khalid, S Asghar, I Khalid, M Irfan, ... Pharmaceuticals 15 (7), 856 , 2022 2022 Citations: 11
In vitro-ex vivo characterization of agarose—carbopol 934® based buccal mucoadhesive tablets containing benzocaine and tibezonium iodide as model drugs A Muhammad, AF Zahoor, MS Iqbal, K Haroon, IU Khan, MA Shah, ... Lat. Am. J. Pharm 41 (5), 1-10 , 2022 2022 Citations: 9
Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits MU Rehman, A Rasul, MI Khan, M Rasool, G Abbas, F Masood, I Nazir, ... Pak. J. Pharm. Sci 34 (1), 313-319 , 2021 2021 Citations: 7
Evaluation of solubility and dissolution of lamotrigine using lipid based microparticulate carriers: An in-vitro analysis. N Islam, M Irfan, AF Zahoor, HK Syed, IU Khan, MS Iqbal, A Rasul, ... Pakistan Journal of Pharmaceutical Sciences 33 , 2020 2020 Citations: 7
Enhancement of solubility and dissolution rate of ebastine fast-disintegrating tablets by solid dispersion method. N Islam, M Irfan, N Abbas, HK Syed, MS Iqbal, A Rasul, S Inam, A Hussain, ... Tropical Journal of Pharmaceutical Research 19 (9) , 2020 2020 Citations: 6
Solubility and dissolution enhancement of dexibuprofen by inclusion complexation with cyclodextrin R Munir, U Mashood, S Asgher, IU Khan, M Irfan, S Inam, N Islam, N Ajaz, ... Lat. Am. J. Pharm 41 (1), 235-43 , 2022 2022 Citations: 5
Improved solubility and stability of aripiprazole in binary and ternary inclusion complexes using methyl-β-cyclodextrin and L-arginine S Awais, K Sultana, MT Ansari, N Islam, M Afridi Pak. J. Pharm. Sci 35 (5), 1415-1422 , 2022 2022 Citations: 3
Improved Bioavailability of Ebastine through Development of Transfersomal Oral Films. Pharmaceutics 2021, 13, 1315 N Islam, M Irfan, AF Zahoor, MS Iqbal, HK Syed, IU Khan, A Rasul, ... s Note: MDPI stays neutral with regard to jurisdictional claims in published … , 2021 2021 Citations: 2
Synthesis and characterization of self-assembling chitosan-based nanoparticles. J Qureshi, FM Iqbal, Z Danish, SNH Shah, H Umar, M Zaman, MN Alvi, ... Pakistan Journal of Pharmaceutical Sciences 35 , 2022 2022 Citations: 1
Effect of Polar Protic Solvents on the Physicochemical Properties and Dissolution of Soluplus Based Solid Dispersions of Rosuvastatin Calcium S Inam, M Irfan, MS Iqbal, HK Syed, N Islam Latin American Journal of Pharmacy 41 (2), 455-462 , 2022 2022
