Morphological, phytochemical, and pharmacological properties of the genus Tamarix in Kazakhstan species: a review Arailym Daulbayeva, Gulnara Kadyrbayeva, Kaldanay Kozhanova, Shazlin Shaharudin, Nurgali Rakhymbayev, Zoya Allambergenova, Rabiga Anarbayeva, Urziya Alimova, Aigerim Kantureyeva, Ainash Baidullaeva, Vladimir An, Bakkonat Kydyrbai Peerj, 2025 The tree-like plants of the genus Tamarix belong to the Tamaricaceae family and predominantly grow in subtropical areas, steppes, and saline soils. These plants exhibit various pharmacological properties, including antioxidant, antidiabetic, anti-inflammatory, and antimicrobial characteristics. The current flora of Kazakhstan also includes 13 Tamarix species. Despite the diversity of the Tamarix taxon, the species discovered in the region have received limited investigation. Therefore, this review analyzed Kazakhstan and international-related scientific studies concerning the morphological, phytochemical, and pharmacological properties of 13 species within the Tamarix genus. The plants’ biological features and potential applications were also comprehensively analyzed. Consequently, this review significantly contributed to botanical science and practical pharmacology. Conservation and sustainable employment of the Tamarix species for medical purposes could also be developed.
STUDY OF THE CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF SUBCRITICAL CO₂ EXTRACT FROM EUPHORBIA HUMIFUSA WILLD Georgian Medical News, 2025
Phytochemical compounds and biomedical properties of Althaea officinalis. Aknur Turgumbayeva, Baimakhanova Baiken, Sadanov Amankeldi, Irina Ratnikova, Saltanat Orasymbet, Erik Shorabaev, Baimakhanova Gul, Amangeldi Alma, Zhalimova Zere, Akzharkyn Saginbazarova, Zaru Kapassova, Nurgali Rakhymbayev, Arystanov Zhalgaskali Pharmacy Practice, 2025 The purpose of this review is to provide a comprehensive overview of the research conducted on the chemical constituents and biological characteristics of Althaea officinalis. Methods: A comprehensive search of scientific databases, including Medline, Scopus, Web of Science, EMBASE, CINAHL, Google Scholar, Researchgate, was conducted. The search included keywords such as " Althaea officinalis", " Althaea officinalis compounds", " Althaea officinalis phytochemicals", " Althaea officinalis pharmacological", and " Althaea officinalis traditional uses". Results: Althaea officinalis, commonly known as marshmallow root, is a perennial herbaceous plant native to Europe and western Asia. It belongs to the Althaea genus of the Malvaceae family. Throughout history, people have recognized the plant ability to relieve symptoms such as a sore throat, dry cough, stomach ulcers, and wounds. Modern pharmacological studies have shown that the extract from this plant has various positive effects, including antitussive, anti-inflammatory, antioxidant, antibacterial, and wound-healing properties. Recent analyses of its chemical composition have revealed that Althaea officinalis contains numerous bioactive compounds, including mucopolysaccharides, flavonoids, phenolic acids, tannins, coumarins, steroids, caffeic acid, ferulic acid, triterpenoids etc. The roots and leaves of Althaea officinalis are used in teas, salads, emollients, and sedatives due to their edible and medicinal qualities. Furthermore, this particular plant is frequently grown for its beautiful flowers, making it a popular choice for ornamental purposes. Currently, Althaea officinalis can be found worldwide due to its widespread cultivation in the agricultural industry. It offers various benefits in the fields of food, healthcare, and dietary supplements. Conclusion: Althaea officinalis, a well-known traditional herbal plant, is readily available and widely used. Recent research efforts have successfully identified numerous chemical components of Althaea officinalis, including flavonoids, polysaccharides, phenolic acids, coumarins, and steroids. These diverse chemical compounds contribute to the plant's various pharmacological properties, such as its ability to alleviate coughs, reduce inflammation, provide antioxidant effects, fight against bacterial infections, and promote wound healing.
STUDY OF THE CHEMICAL COMPONENTS OF CO2 EXTRACTS FROM THE UNDERGROUND PART OF FERULA ASAFOETIDA L Serzhan Mombekov, Nurgali Rakhymbayev, Kairat Zhakipbekov, Bayan Sagindykova, Symbat Akhatova, Maral Amirov, Iryna Zhuravel, Akmaral Nurmahanova, Murat Ashirov, Arailym Daulbayeva, Sergii Kolisnyk Sciencerise Pharmaceutical Science, 2025 The aim of this study was to determine the chemical composition of the CO2 extract obtained from the underground part of Ferula asafoetida L., a plant widely used in traditional Kazakhstani medicine, with a particular focus on the amino acid and fatty acid profiles. Materials and methods. The plant material was collected in accordance with current Good Agricultural and Collection Practice (GACP) guidelines and underwent thorough pre-processing. A subcritical CO2 extraction method was applied to preserve thermolabile and volatile components while minimizing solvent residues. Chemical analysis was performed using GC-MS, and the amino acid and fatty acid profiles were determined by gas-liquid chromatography (GLC) based on standardized methods. Results. The resulting CO₂ extract had a high proportion of unsaturated fatty acids (90.2 %), primarily oleic acid (46.1 %) and linoleic acid (43.0 %), along with a complete set of 20 amino acids, including 25.92 % essential amino acids. The major bioactive compounds identified were 9,12-Octadecadienoic acid, ethyl ester (18.61 %) and ethyl oleate (13.18 %), which have potential antioxidant and anti-inflammatory properties. These findings suggest the extract’s suitability for pharmaceutical and nutraceutical applications. Conclusions. Although the extract shows promising potential for pharmaceutical applications, further verification through comprehensive pharmacological studies is necessary
Development of the Composition and Technology of a gel with extract of Portulaca oleracea L Karlygash T. Raganina, Meruyert I. Tleubayeva, Raisa М. Abdullabekova, Nurgali A. Rakhymbayev, Elmira N. Kapsalyamova, Gaukhar I. Yeshenkulova Research Journal of Pharmacy and Technology, 2025 The article presents the results of research on the development of the composition and technology of a gel with ultrasonic ethanolic extract Portulaca oleracea L. for topical use. A gel under the conditional name PortoGel was taken as the object of the study. An ultrasonic ethanolic extract of Portulaca oleracea L. (POUS extract) was used as an active component. Since ancient times, the plant Portulaca oleracea L. has been used in traditional medicine in many countries to treat various diseases. A rational technology for producing the gel has been developed, and its indicators such as appearance, uniformity, smell, plasticity, viscosity, and pH have been studied. Sapineo Derm (sodium hydroxyethylacrylate/acryloyldimethyltaurate) was selected as a structure former. Sodium alginate is selected as a thickener and stabilizer. Boric acid, 0.1% Tea Tree oil extract as antimicrobial preservatives. Based on rheological studies (Brookfield HBDV-2), it was determined that PortoGel has optimal structural and mechanical characteristics, is a thixotropic system, sufficiently stable and pliable, capable of being spread on the skin, and provides the necessary stability of the system during technological operations. This study showed that the gel contains the active ingredient of Portulaca oleracea L. extract. It is promising for further work on the creation of medicines.
COMPARATIVE STUDY OF ANTIBACTERIAL EFFECTS OF MODIFIED PREPARATIONS CONTAINING METAL NANOPARTICLES Georgian Medical News, 2025
INTRODUCTION OF MODERN RESOURCE-SAVING TECHNOLOGIES AT PHARMACEUTICAL ENTERPRISES (LEAN MANUFACTURING APPROACHES) Askar NYSANKULOV, Zhanerke SEITOVA, Arailym DAULBAYEVA, Murat ASHIROV, Nurgali RAKHYMBAYEV, Kairat ZHAKIPBEKOV Phytotherapy Journal, 2025 Actuality.Pharmaceutical companies are challenged to improve efficiency, reduce costs, and comply with strict regulatory requirements.Lean manufacturing approaches are considered an effective way to save resources, optimize processes, and improve quality continuously.Aim of the study is analyzes of the theoretical foundations of lean manufacturing for determining of the key stages of implementation at the pharmaceutical enterprises.Material and methods.The study was conducted in two stages: a review of domestic and foreign literature for 2000-2025 using Google Scholar, PubMed, Scopus, and Web of Science searches for relevant keywords; analytical summary of pharmaceutical manufacturing practices with a focus on production processes, quality control systems, loss reduction methods, and resource . 4, 2025. conservation strategies.At the second stage of the study, pharmaceutical production processes, quality control systems, loss reduction methods and resource-saving strategies were analyzed. Research results. A six-step implementation sequence has been identified: diagnosis and goal setting; mapping and analysis of losses; development and implementation of improvements; staff training and Kaizen culture development; monitoring and corrective actions; final assessment. It has been shown that integrating Lean with digital technologies enhances quality control and flexibility.According to the case studies reviewed, quality control reliability increased by more than 50%, inventory and defects were reduced by approximately 57%, throughput increased, and work in progress decreased.Three implementation scenarios (maximum, moderately optimal, "soft") are proposed, describing the limitations and risks for companies with varying degrees of readiness.Conclusion.Lean manufacturing, enhanced by digital tools, reduces losses, inventory, and defects, speeds up processes, and improves the quality and productivity of pharmaceutical production.In the context of rising costs, stricter standards and environmental requirements, it is becoming a strategic factor of competitiveness, especially for developing countries.For the first time, a standard Lean manufacturing implementation plan has been proposed with three scenarios -"maximum", "moderate-optimal" and "soft", which allows flexible strategy selection depending on resources.The results can be applied to the implementation of Lean manufacturing in pharmaceutical enterprises, in particular The Republic Kazakhstan.
STUDY OF THE CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF SUBCRITICAL CO2 EXTRACT FROM EUPHORBIA HUMIFUSA WILLD Georgian Medical News, 2025
Optimization of Drug Provision for Patients With Rheumatoid Arthritis Based on a Pharmacoeconomic Analysis in the Republic of Kazakhstan Kairat S. Zhakipbekov, Elmira A. Serikbayeva, Aknur A. Turgumbayeva, Nurgali A. Rakhymbayev, Murat Z. Ashirov, Zhanna V. Mironenkova, Sergey Z. Umarov, Karlygash M. Akpayeva Vestnik Rossijskoj Voenno Medicinskoj Akademii, 2025 BACKGROUND: Providing the least costly, safe, and highly effective pharmacotherapy to patients with rheumatoid arthritis remains an urgent issue.AIM: This work aimed to develop approaches for optimizing drug provision for patients with rheumatoid arthritis (using the city of Almaty as an example).METHODS: This work used the information resources of the Ministry of Health of the Republic of Kazakhstan; reports from the Almaty City Rheumatology Center, the State Register of Medicinal Products of the Republic of Kazakhstan, the Clinical Protocol for the Diagnosis and Treatment of Rheumatoid Arthritis No. 12 dated September 29, 2016; wholesale prices for medicinal products, antineoplastic agents, and immunomodulators (anatomical therapeutic chemical groups L01, L04) provided by the City Rheumatology Center; and statistical indicators accumulated based on data from the World Health Organization and the Bureau of National Statistics of the Agency for Strategic Planning and Reforms of the Republic of Kazakhstan.RESULTS: The highest disease prevalence (60%) was observed among working-age patients aged 35–55 years, whereas only 0.36% of the medicinal products used belonged to biologic agents. The cost ranking (ascending order) of adverse drug reaction therapy was as follows: adalimumab, etanercept, rituximab, tocilizumab, golimumab, and infliximab. With regard to additional cost expenditures, the leading agents (based on the lowest cost of the treatment course) were golimumab, rituximab, and infliximab. The lowest total treatment cost across all treatment stages (in ascending order) was identified for etanercept, adalimumab, and infliximab.CONCLUSION: Strengthening physician-led patient education regarding treatment strategies is necessary to improve adherence among patients with rheumatoid arthritis. To expand therapy options, the inclusion of etanercept in the guaranteed free medical care list must be considered. To reduce expenditures for medicinal provision, producing biologic agents in the Republic of Kazakhstan is required.
