VELLIYUR KANNIAPPAN GOPALAKRISHNAN

@bhu.edu.et

PROFESSOR IN BIOCHEMISTRY, SCHOOL OF MEDICINE, BULE HORA UNIVERSITY INSTITUTE OF HEALTH
BULE HORA UNIVERSITY, ETHIOPIA

VELLIYUR KANNIAPPAN GOPALAKRISHNAN


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https://researchid.co/vkgopalakrishnan

EDUCATION

Ph.D. Biochemistry
1996 University of Madras, Dr. ALMPGIBMS, Taramani Campus, Chennai.

Doctoral thesis title: Biochemical studies on the effect of cis-diammine dichloro platinum - II (cisplatin) and sodium selenite in experimental fibrosarcoma rats.

M. Phil., Biochemistry
1990 University of Madras, Dr. ALMPGIBMS, Taramani Campus, Chennai.

M.Phil thesis title: Mycotoxicoses, effect of patulin on plasma proteins. A preliminary study in rats.

M.Sc. Biochemistry
1988 University of Madras, Dr. ALMPGIBMS, Taramani Campus, Chennai.

B.Sc., Chemistry
1986 MSSWB College, Madurai Kamaraj University, Madurai.

RESEARCH INTERESTS

• Anticancer effect of Medicinal plants against prostate and ovarian cancer in vitro, in vivo and in silico model.
• Antidiabetic and anti-inflammatory activity of medicinal plants.
• Synthesis and Characterization of Nanoparticles from medicinal plants against cancer cell lines.
4069

Scholar Citations

34

Scholar h-index

118

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Sustainable fabrication of biopolymer-based (starch/PVA) nanoscaffolds loaded with green-synthesized CuO nanoparticles from Sargassum wightii (marine macroalgae …
    CPP JinJin Pei, Hanisha Govindaraj, Sivaramakrishnan R, Gopalakrishnan ...
    Biomaterials Advances 182, 214660 , 2026
    2026
    Citations: 3
  • Antioxidant and biocompatible CuO-starch/PVA nanoscaffolds via ultrasonic green synthesis using Turbinaria conoides (brown marine macroalgae)
    IDMCPP Pooja Shree Sugumar, R Sivaramakrishnan, Gopalakrishnan Velliyur ...
    Medicine in Drug Discovery 28, 100238 , 2025
    2025
    Citations: 2
  • Unraveling the Structural Consequence of Pathogenic Single Nucleotide Polymorphisms in the Human Aldosterone Synthase: An in silico Approach
    VJGVK Dhamodharan Prabhu, Murugan Mukilan, Muthu Krishnan Dhivya Dharshini
    Research Journal of Biotechnology 20 (11), 30-41 , 2025
    2025
  • Phytochemical insights, antioxidant activity and therapeutic potential of Cassia senna against prostate cancer in Wistar albino rats
    CPPGVK Guru Kumar Dugganaboyana, Mohan Krishna Gunjevu Kannankumar, Sahana ...
    Discover Applied Sciences 7, 1206 , 2025
    2025
    Citations: 1
  • Enhanced in vitro anticancer activity of liposome-encapsulated nanocordycepin in breast and cervical cancer cells
    GVKGKD Sneha Sridhar, Subba Rao V. Madhunapantula, Prathibha Ranganathan
    Discover Applied Sciences 7, 1172 , 2025
    2025
  • Harnessing Nature: Computational and Experimental Insights into Ipomoea obscura Metabolites for Bladder Cancer Therapy
    MT 2. Saravana Prabha Poochi, Rajamanikandan Sundarraj, Manikandan Vani Raju ...
    Chemistry &Biodiversity , 2025
    2025
  • Physicochemical characterization of starch from Maranta arundinacea L. (arrowroot) rhizomes and its inhibition of COX-2: In vivo validation
    GVK Nishaa S, Manikandan V.R, Rathi M.A, Meenakshi K.C, Chella Perumal P ...
    Bioactive Carbohydrates and Dietary Fibre 33, 100465 , 2025
    2025
    Citations: 6
  • Hepatoprotective effects of ethanolic extract of Corallocarpus epigaeus roots on nitrobenzene induced liver injury in Wistar rats
    GVK Durga Priya D, Meenakshi K. C, Manikandan V.R, Rathi M. A ...
    Journal of Herbs Spices and Medicinal Plants 31 (1), 49–65 , 2025
    2025
    Citations: 3
  • Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: A computational approach
    GVK Poornima K, Meenakshi K.C, Manikandan V.R, Shankari G, Prabhu D, Rathi M ...
    Journal of Complement Integrative Medicine 22 (2), 363–372 , 2025
    2025
    Citations: 3
  • Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of Emilia sonchifolia (L.) DC against the pancreatic …
    RMAGVK Pratibha P, Chella Perumal P, Abirami S, Prabhu D, Harshini S, Dhivya D
    Journal of Complement Integrative Medicine 22 (1), 165-172 , 2025
    2025
    Citations: 1
  • Reconnoitering the role of Lipid Metabolites in Ferroptosis
    GVK Manikandan Vani Raju, Meenakshi Kaniyur Chandrasekaran, Rathi Muthaiyan ...
    Advances in Redox Research 14, 100117 , 2025
    2025
    Citations: 13
  • Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management
    PCP Pei J, Kumarasamy RV, Jayaraman S, Kanniappan GV*, Long Q
    Ageing Research Reviews 104, 102665 , 2025
    2025
    Citations: 51
  • Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications
    PCPMID Jiang H, Ranil Vikraman Kumarasamy R.V., Pei J, Raju K, Kanniappan GV*
    Frontiers in Nanotechnology 6, 1513683 , 2025
    2025
    Citations: 17
  • In vitro anticancer effects of ethanolic extract of Pandanus odorifer flower on HT-29 colon cancer cells by targeting p53 pathway
    GVK Meenakshi Kaniyur Chandrasekaran, Manikandan Vani Raju, Rathi Muthaiyan ...
    Indian Journal of Natural Products and Resources 16 (1), 80-88 , 2025
    2025
    Citations: 1
  • Comprehensive review on single-cell RNA sequencing: A new frontier in Alzheimer’s disease research
    CPP Wengang J, JinJin P, Jeane Rebecca R, Selvaraj J, Rathi M. A ...
    Ageing Research Reviews 100, 102454 , 2024
    2024
    Citations: 24
  • Artificial Intelligence tools to address Challenges of Antimicrobial Resistance in Pathogenic Biofilm Systems.
    VK Mishra, AG Banerjee
    Artificial Intelligence Tools to Address Challenges of Antimicrobial … , 2024
    2024
  • Antibacterial and biofilm disruptive nonribosomal lipopeptides from Streptomyces parvulus against multidrug-resistant bacterial infections
    S Kadaikunnan, P Vijayaragavan, MA Rathi, B Balamuralikrishnan, ...
    Journal of Infection and Public Health 17 (3), 450-456 , 2024
    2024
    Citations: 10
  • Glutamine Synthase Expression Profiling and Selective Inhibitor for Burkholderia psuedomallei K96243: An In-silico Approach
    GVK Sumithra G, Vishnu Priya M
    Texila International Journal of Public Health 12 (SE), 19 , 2024
    2024
  • Comprehensive review on single-cell RNA sequencing: A new frontier in Alzheimer's disease research
    PCP Jin W, Pei J, Roy JR, Jayaraman S, Ahalliya RM, Kanniappan GV*, Mironescu M
    Ageing Research Reviews 100, 102454 , 2024
    2024
  • Investigating the antioxidant properties and GC-MS profile of Indian native medicinal flower Pandanus odorifer and assessing its cytotoxic effects on HT-29 cells
    RMA Meenakshi KC, Manikandan VR, Boopana D, Gopalakrishnan VK
    International Journal of Ayurvedic Medicine 15 (3), 650-659 , 2024
    2024
    Citations: 4

MOST CITED SCHOLAR PUBLICATIONS

  • Functional group analysis of various extracts of Aerva lanata (L.,) by FTIR spectrum
    P Ragavendran, D Sophia, C Arul Raj, VK Gopalakrishnan
    Pharmacologyonline 1, 358-364 , 2011
    2011
    Citations: 161
  • Antioxidant activity of ethanolic extract of Maranta arundinacea L. tuberous rhizomes
    S Nishaa, M Vishnupriya, JM Sasikumar, PC Hephzibah, ...
    Asian Journal of Pharmaceutical and Clinical Research 5 (4), 85-88 , 2012
    2012
    Citations: 146
  • Production, purification and characterization of invertase by Aspergillus flavus using fruit peel waste as substrate
    C Uma, D Gomathi, C Muthulakshmi, VK Gopalakrishnan
    Adv Biol Res 4 (1), 31-36 , 2010
    2010
    Citations: 113
  • Radical scavenging and antioxidant activity of ethanolic extract of Mollugo nudicaulis by in vitro assays
    S Rajamanikandan, T Sindhu, D Durgapriya, D Sophia, P Ragavendran, ...
    Indian Journal of Pharmaceutical Education and Research 45 (4), 310-316 , 2011
    2011
    Citations: 103
  • Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester
    E Babu, VK Gopalakrishnan, INP Sriganth, R Gopalakrishnan, ...
    Molecular and cellular biochemistry 144 (1), 7-11 , 1995
    1995
    Citations: 99
  • Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines
    JK Vishwanatha, E Salazar, VK Gopalakrishnan
    BMC cancer 4 (1), 8 , 2004
    2004
    Citations: 86
  • Screening and GC-MS profiling of ethanolic extract of Tylophora pauciflora
    T Starlin, PS Prabha, BKA Thayakumar, VK Gopalakrishnan
    Bioinformation 15 (6), 425 , 2019
    2019
    Citations: 81
  • Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA
    AG Banerjee, J Liu, Y Yuan, VK Gopalakrishnan, SL Johansson, ...
    Molecular cancer 2 (1), 34 , 2003
    2003
    Citations: 81
  • Antidiabetic Activity of Ethanolic Extract of Zaleya decandra in Alloxan-Induced Diabetic Rats
    P Meenakshi, R Bhuvaneshwari, MA Rathi, L Thirumoorthi, DC Guravaiah, ...
    Applied biochemistry and biotechnology 162 (4), 1153-1159 , 2010
    2010
    Citations: 80
  • Hepatoprotective activity of ethanolic extract of Alysicarpus vaginalis against nitrobenzene-induced hepatic damage in rats
    MA Rathi, P Meenakshi, VK Gopalakrishnan
    South Indian Journal of Biological Sciences 1 (2), 60-65 , 2015
    2015
    Citations: 71
  • In vitro antioxidant activities and HPTLC analysis of ethanolic extract of Cayratia trifolia (L.)
    PC Perumal, D Sophia, CA Raj, P Ragavendran, T Starlin, ...
    Asian Pacific Journal of tropical disease 2, S952-S956 , 2012
    2012
    Citations: 71
  • Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar albino rats
    K Devaki, U Beulah, G Akila, VK Gopalakrishnan
    Toxicology International 19 (1), 63 , 2012
    2012
    Citations: 69
  • Phytochemical screening, functional groups and element analysis of Tylophora pauciflora wight and arn
    T Starlin, RC Arul, P Ragavendran, VK Gopalakrishnan
    Int Res J Pharm 3 (6), 180-83 , 2012
    2012
    Citations: 65
  • Phytochemical screening and GC-MS analysis of ethanolic extract of rhizomes of Maranta arundinacea L.
    S Nishaa, M Vishnupriya, JM Sasikumar, VK Gopalakrishnan
    2013
    Citations: 61
  • Antimicrobial activity of Moringa oleifera (Lam.) root extract
    AJ Raj, VK Gopalakrishnan, SA Yadav, S Dorairaj
    Journal of Pharmacy Research 4 (5), 1426-1427 , 2011
    2011
    Citations: 60
  • Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein
    TK Saravana Prabha P, Murugesh E, Balamuralikrishnan B, Mohan A, Arun M ...
    Food Frontiers 1, 168-179 , 2020
    2020
    Citations: 58
  • Deregulated cyclooxygenase-2 expression in oral premalignant tissues
    AG Banerjee, VK Gopalakrishnan, I Bhattacharya, JK Vishwanatha
    Molecular cancer therapeutics 1 (14), 1265-1271 , 2002
    2002
    Citations: 56
  • Enzymatic and non-enzymatic antioxidant properties of Tylophora pauciflora wight and arn.-An in vitro study
    T Starlin, VK Gopalakrishnan
    Asian J. Pharm. Clin. Res 6 (4), 152-157 , 2013
    2013
    Citations: 55
  • Identification of novel PPARγ agonist from GC-MS analysis of ethanolic extract of Cayratia trifolia (L.): a computational molecular simulation studies
    PC PERUMAL, S SOWMYA, P PRATIBHA, B VIDYA, P ANUSOORIYA, ...
    Journal of Applied Pharmaceutical Science 4 (9), 006-011 , 2014
    2014
    Citations: 53
  • NF-κB activation and proinflammatory cytokines mediated protective effect of Indigofera caerulea Roxb. on CCl4 induced liver damage in rats
    G Ponmari, A Annamalai, VK Gopalakrishnan, PTV Lakshmi, ...
    International Immunopharmacology 23 (2), 672-680 , 2014
    2014
    Citations: 52

Publications

Google scholar: 0UaRDzwAAAAJ

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GRANT DETAILS

Completed Projects

1. Co-investigator in Department of Science and Technology (DST), New Delhi, India, Funded Major Research Project on “Development of mechanism-based antidiabetic formulation, standardization from Indian Traditional Herbz viz., bioavailability, stability studies” Amount sanctioned for the period of three years. lakhs.

2. Principal Investigator in University Grants Commission (UGC) New Delhi, India, Funded Major Research Project on “Expression of transfected FHIT gene in ovarian cancer cell lines” Amount sanctioned for the period of three years (01.04.2007-31.03.2010) Rs-8,03, 600.00 F.No 32-607/2006(SR) dated 02March 2007

3. Principal Investigator in Indian Council of Medical and Research (ICMR) New Delhi, India, Funded Major Research Project on “Anticancer effect of Medicinal Plants on Prostate Cancer Progression Model in vitro” Amount sanctioned for the period of two years (15.05.2007 – 14.5.2009) dated 07.05.2007